1,954 results on '"Kobashigawa, Jon"'
Search Results
2. Full Collection of Personal Narratives
- Author
-
Jagsi, Reshma, Perlmutter, Joel S., Curti, Brendan D., Matthews, Leslie, Murray, Leah, Hoke, Ahmet, Draper, Lauren, Burack, Michelle A., Malone, James, Kobashigawa, Jon A., Carr, Brent R., Adler, Kenneth R., Hadaway, Cheryl J., and Behrns, Kevin E.
- Published
- 2022
- Full Text
- View/download PDF
3. Heart retransplant recipients with renal dysfunction benefit from simultaneous heart-kidney transplantation.
- Author
-
Malas, Jad, Chen, Qiudong, Emerson, Dominic, Megna, Dominick, Catarino, Pedro, Czer, Lawrence, Patel, Jignesh, Kittleson, Michelle, Kobashigawa, Jon, Chikwe, Joanna, Bowdish, Michael, and Esmailian, Fardad
- Subjects
chronic kidney disease ,dual organ transplantation ,end-stage heart failure ,heart retransplantation ,simultaneous heart-kidney ,transplantation ,Adult ,Humans ,Kidney Transplantation ,Treatment Outcome ,Retrospective Studies ,Kidney ,Heart Transplantation ,Kidney Diseases ,Graft Survival - Abstract
BACKGROUND: Given ongoing donor shortages, appropriate patient selection for dual-organ transplantation is critical. We evaluated outcomes of heart retransplant with simultaneous kidney transplant (HRT-KT) vs isolated heart retransplant (HRT) across varying levels of renal dysfunction. METHODS: The United Network for Organ Sharing database identified 1189 adult patients undergoing heart retransplantation between 2005 and 2020. Recipients undergoing HRT-KT (n = 251) were compared to those undergoing HRT (n = 938). The primary outcome was 5-year survival; subgroup analyses and multivariable adjustment were performed utilizing the following 3 estimated glomerular filtration (eGFR) groups: 45 ml/min/1.73m2. RESULTS: HRT-KT recipients were older and had longer waitlist times, longer inter-transplant periods, and lower eGFR levels. HRT-KT recipients were less likely to require pretransplant ventilator (1.2% vs 9.0%, p < 0.001) or ECMO (2.0% vs 8.3%, p < 0.001) support but were more likely to have severe functional limitation (63.4% vs 52.6%, p = 0.001). After retransplantation, HRT-KT recipients had less treated acute rejection (5.2% vs 9.3%, p = 0.02) and more dialysis requirement (29.1% vs 20.2%, p < 0.001) before discharge. Survival at 5-years was 69.1% after HRT and 80.5% after HRT-KT (p < 0.001). After adjustment, HRT-KT was associated with improved 5-year survival among recipients with eGFR 45 ml/min/1.73sm2 (HR 0.68, 95% CI 0.30-1.54). CONCLUSION: Simultaneous kidney transplantation is associated with improved survival following heart retransplantation in patients with eGFR
- Published
- 2023
4. Simultaneous heart-kidney transplant in patients with borderline estimated glomerular filtration rate without dialysis dependency.
- Author
-
Chen, Qiudong, Malas, Jad, Gianaris, Kevin, Esmailian, Gabriel, Emerson, Dominic, Megna, Dominick, Catarino, Pedro, Czer, Lawrence, Bowdish, Michael, Chikwe, Joanna, Patel, Jignesh, Kobashigawa, Jon, and Esmailian, Fardad
- Subjects
United Network for Organ Sharing ,heart disease ,organ allocation ,patient survival ,Adult ,Humans ,Kidney Transplantation ,Glomerular Filtration Rate ,Renal Dialysis ,Retrospective Studies ,Kidney ,Heart Transplantation - Abstract
BACKGROUND: Appropriate patient selection for simultaneous heart-kidney transplantation (sHK) in patients with moderate renal dysfunction remains challenging. METHODS: From the United Network for Organ Sharing database (2003-2020), we identified 5678 adults with an estimated pre-transplant glomerular filtration rate (eGFR) between 30 and 45 mL/min/1.73 m2 and no pre-transplant dialysis. Patients undergoing sHK (n = 293) were compared with those undergoing heart transplantation alone (n = 5385) using 1:3 propensity score matching. RESULTS: The sHK utilization rate increased from 1.8% in 2003 to 12.2% in 2020 (p
- Published
- 2023
5. Experience With SynCardia Total Artificial Heart as a Bridge to Transplantation in 100 Patients.
- Author
-
Malas, Jad, Chen, Qiudong, Akhmerov, Akbarshakh, Tremblay, Louis, Egorova, Natalia, Krishnan, Aasha, Moriguchi, Jaime, Kobashigawa, Jon, Czer, Lawrence, Cole, Robert, Emerson, Dominic, Chikwe, Joanna, Arabia, Francisco, and Esmailian, Fardad
- Subjects
Humans ,Prospective Studies ,Heart ,Artificial ,Heart Transplantation ,Heart Failure ,Registries ,Heart-Assist Devices - Abstract
BACKGROUND: The SynCardia temporary total artificial heart (TAH-t) is an effective bridge to transplantation for patients with severe biventricular failure. However, granular single-center data from high-volume centers are lacking. We report our experience with the first 100 TAH-t recipients. METHODS: A prospective institutional database was used to identify 100 patients who underwent 101 TAH-t implantations between 2012 and 2022. Patients were stratified and compared according to Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 vs 2 or greater. Median follow-up on device support was 94 days (interquartile range, 33-276), and median follow-up after transplantation was 4.6 years (interquartile range, 2.1-6.0). RESULTS: Overall, 61 patients (61%) were successfully bridged to transplantation and 39 (39%) died on TAH-t support. Successful bridge rates between INTERMACS profile 1 and INTERMACS profile 2 or greater patients were similar (55.6% [95% CI, 40.4%-68.3%] vs 67.4% [95% CI, 50.5%-79.6%], respectively; P = .50). The most common adverse events (rates per 100 patient-months) on TAH-t support included infection (15.8), ischemic stroke (4.6), reoperation for mediastinal bleeding (3.5), and gastrointestinal bleeding requiring intervention (4.3). The most common cause of death on TAH-t support was multisystem organ failure (n = 20, 52.6%). Thirty-day survival after transplantation was 96.7%; survival at 6 months, 1 year, and 5 years after transplantation was 95.1% (95% CI, 85.4%-98.4%), 86.6% (95% CI, 74.9%-93.0%), and 77.5% (95% CI, 64.2%-86.3%), respectively. CONCLUSIONS: Acceptable outcomes can be achieved in the highest acuity patients using the TAH-t as a bridge to heart transplantation.
- Published
- 2023
6. Special Patient Populations
- Author
-
Kobashigawa, Jon A., primary, FellstrÖm, Bengt, additional, Mark, Patrick B., additional, and Jardine, Alan G., additional
- Published
- 2024
- Full Text
- View/download PDF
7. Contributors
- Author
-
Agha, Ali M., primary, Alexander, Lydia C., additional, Ballantyne, Christie M., additional, Bays, Harold, additional, Bhatt, Deepak L., additional, Blumenthal, Roger S., additional, Boffa, Michael B., additional, Bond, Rachel M., additional, Brandts, Julia M., additional, Brinton, Eliot A., additional, Brothers, Julie A., additional, Catapano, Alberico L., additional, Chan, Dick C., additional, Chiavaroli, Laura, additional, Cho, Laura Browning, additional, Cho, Leslie, additional, Cummings, Danielle, additional, Daniels, Stephen R., additional, Deshotels, Matthew R., additional, Dove, Erik, additional, Feldman, David I., additional, Fellström, Bengt, additional, Ferdinand, Keith C., additional, Fichtenbaum, Carl J., additional, Fitch, Angela, additional, Gaudet, Daniel, additional, Ginsberg, Henry N., additional, Gluckman, Ty J., additional, Hegele, Robert A., additional, Hoogeveen, Ron C., additional, Hussain, Aliza, additional, Jardine, Alan G., additional, Jenkins, David J.A., additional, Jones, Peter H., additional, Jones, Peter, additional, Kachur, Sergey M., additional, Kendall, Cyril W.C., additional, Knowles, Joshua W., additional, Kobashigawa, Jon A., additional, Koschinsky, Marlys L., additional, Kris-Etherton, Penny M., additional, Lavie, Carl J., additional, Libby, Peter, additional, Marcovina, Santica M., additional, Mark, Patrick B., additional, Marston, Nicholas A., additional, Martin, Seth Shay, additional, Michos, Erin D., additional, Mirrahimi, Arash, additional, Mora, Samia, additional, Moriarty, Patrick M., additional, Nambi, Vijay, additional, Nelson, Adam J., additional, Nicholls, Stephen J., additional, Nissen, Steven E., additional, Nordestgaard, Børge Grønne, additional, Norata, Giuseppe Danilo, additional, Orringer, Carl, additional, Palmisano, Brian T., additional, Patel, Darshna, additional, Patel, Rajan K., additional, Pulipati, Vishnu Priya, additional, Raal, Frederick J., additional, Rader, Daniel J., additional, Ray, Kausik K., additional, Richter, Chesney, additional, Ridker, Paul M., additional, Sabatine, Marc S., additional, Safarova, Maya S., additional, Santos, Raul D., additional, Saseen, Joseph J., additional, Schwartz, Gregory G., additional, Shustak, Rachel J., additional, Sievenpiper, John L., additional, Singh, Nickpreet, additional, Skulas-Ray, Ann C., additional, Srichaikul, Kristie, additional, Stone, Neil J., additional, Tokgözoğlu, Lale, additional, Tybjærg-Hansen, Anne, additional, Virani, Salim S., additional, Watson, Karol, additional, Watts, Gerald F., additional, Wenger, Nanette K., additional, and Wong, Julia M.W., additional
- Published
- 2024
- Full Text
- View/download PDF
8. Ten-year follow-up cohort of the everolimus versus azathioprine multinational prospective study focusing on intravascular ultrasound findings
- Author
-
Kim, In-Cheol, Starling, Randall C., Khush, Kiran, Passano, Elizabeth, Mirocha, James, Bernhardt, Peter, Azarbal, Babak, Cheng, Richard, Esmailian, Fardad, Mancini, Donna, Patel, Jignesh K., Sato, Takuma, Varnous, Shaida, and Kobashigawa, Jon A.
- Published
- 2024
- Full Text
- View/download PDF
9. Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial
- Author
-
Pracoń, Radosław, Spertus, John A., Broderick, Samuel, Bangalore, Sripal, Rockhold, Frank W., Ruzyllo, Witold, Demchenko, Elena, Nageh, Thuraia, Grossman, Gabriel Blacher, Mavromatis, Kreton, Manjunath, Cholenahally N., Smanio, Paola E.P., Stone, Gregg W., Mancini, G.B. John, Boden, William E., Newman, Jonathan D., Reynolds, Harmony R., Hochman, Judith S., Maron, David J., Doan, John, Linefsky, Jason, Lee, Raven, Patel, Risha, Miller, Todd, Yang Cho, So, Milbrandt, Susan, Shelstad, Dawn, Banerjee, Subhash, Kamath, Preeti, Tejani, Ishita, Cobos, Stanley E., Quiles, Kirsten J., Dwyer, Raven R., Donnino, Robert M., Espinosa, Dalisa, Phillips, Lawrence M., Saric, Muhamed, Abdul-Nour, Khaled, Schley, Allison, Golden, Heather, Stone, Peter H., Osseni, Hermine, Wiyarand, Charlene, Douglass, Peter, Pomeroy, Hayley, Craft, Alexandra, Harvey, Bethany, Jang, James J., Anaya, Olivia, Yee, Gennie, Goold, Phoebe, Weitz, Steven, Giovannone, Steven, Pritchard, Lori, Arnold, Suzanne, Gans, Rosann, Henry O’Keefe, Jr, James, Kennedy, Paul, Shapiro, Michael D., Ganesan, Shobana, Schlichting, David, Naher, Aynun, El-Hajjar, Mohammad, Sidhu, Mandeep S., Fein, Steven A., Stewart, Wendy L., Torosoff, Mikhail T., Salmi, Kristin M., Lyubarova, Radmila, Mookherjee, Sulagna, Drzymalski, Krzysztof, McFalls, Edward O., Garcia, Santiago A., Bertog, Stefan C., Johnson, Debra K., Siddiqui, Rizwan A., Herrmann, Rebekah R., Ishani, Areef, Hansen, Ronnell A., Georges Khouri, Michel, Arges, Kristine, LeFevre, Melissa, Tomfohr, Jennifer, Goldberg, Jonathan L., Ann Byrne, Kimberly, Zappernick, Taissa, Goldweit, Richard, Canada, Sallie, Kakade, Meghana, Mieses, Patricia, Cobos, Stanley E., Dwyer, Raven R., Cohen, Ronny A., Espinosa, Dalisa, Mirrer, Brooks, Quiles, Kirsten J., Navarro, Victor, Rantinella, Magdalena, Rodriguez, Jessica, Mancilla, Olivia, Winchester, David E., Stinson, Susan, Kronenberg, Marvin, Weyand, Terry, Rogal, Philip, Crook, Sherron C., McFarren, Christopher, Heitner, John F., Ho, Jean, Khan, Saadat, Mohamed, Mahmoud, Dauber, Ira M., Soltau, Mary R., Rose, Delsa K., Wimmer, Rebecca J., Siegel, Kathy E., Derbyshire, Susan, Cannan, Charles, Dixon, Michelle, Leonard, Gerald, Sudarshan, Sriram, Heard, Ciarra, Gabriel, Viviana, Desire, Sukie, Mehta, Puja K., McDaniel, Michael, Rashid, Fauzia, Lerakis, Stamatios, Asier, Senait, Quyyumi, Arshed, Patel, Keyur, Wenger, Nanette K., Hedgepeth, Chester M., Gillis, Jennifer, Hurlburt, Heather, Manocchia, Megan, Rosen, Alan, Moore, Susan, Congdon, Elizabeth, Sahul, Zakir, Brandt, Gail, Marchelletta, Nora, Wippler, Kristina, Booth, David, Taul, Yvonne, Leung, Steve, Isaacs, Jennifer, Abdel-Latif, Ahmed, Bulkley, Viktoria, Reda, Hassan, Rodgers, Caroline, Ziada, Khaled, Setty, Sampoornima, Halverson, Kimberly E., Roraff, Christine, Thorsen, Jonean, Barua, Rajat S., Ojajuni, Amarachi, Olurinde, Oni, Surineni, Kamalakar, Hage, Fadi, Valaiyapathi, Badhma, Caldeira, Christiano, Davies, James E., Leesar, Massoud, Heo, Jaekyeong, Iskandrian, Amy, Al Solaiman, Firas, Singh, Satinder, Dajani, Khaled, Kartje, Carol M., El-Hajjar, Mohammad, Mesropian, Paul Der, Sacco, Joseph, Rawlins, Michele, McCandless, Brian, Thomson, Jennifer, Orgera, Marisa, Sidhu, Mandeep S., Colleen Rogge, Mary, Arif, Imran, Bunke, Julie, Kerr, Hanan, Unterbrink, Kendra, Fannon, Jacqueline, Burman, Cynthia, Trejo, Jorge F., Dubin, Marcia F., Fletcher, Gerald, Lane, Gary E., Neeson, Lynn M., Parikh, Pragnesh P., Pollak, Peter M., Shapiro, Brian P., Landolfo, Kevin, Gemignani, Anthony, Beaudry, Sarah, O’Rourke, Daniel, Meadows, Judith L., Tirado, Stephanie A., Halliday, Janet, Julian, Pamela, Call, Jason T., Lane, Stephanie M., Stanford, Jennifer L., Hannan, Joseph, Bojar, Robert, Arsenault, Patricia, Kumar, Deepti, Sigel, Pamela, Mukai, John, Martin, Edward T., Brooks, Miriam, Vorobiof, Gabriel, Douangvila, Ladda, Gevorgyan, Rubine, Moorman, Alec, Ranjbaran, Fatima, Smith, Bryn, Ohmart, Carly, Kinlay, Scott, Hamburger, Robert J., Rocco, Thomas P., Ly, Samantha, Bhatt, Deepak L., Quinn, Margot C., Croce, Kevin, Temiyasathit, Sara, Quin, Jacquelyn A, Do, Jacquelyn, Anumpa, Jati, Tobin, Desiree, Zenati, Marco, Faxon, David P, Rayos, Glenn, Langdon, Jennifer, Werner Bayer, Marcia, Seedhom, Ashraf, O’Malley, Amanda, Sullenberger, Lance, Orvis, Erin, Kumkumian, Gregory, Murphy, Mandy, Greenberg, Ann, Iraola, Margaret, Sedlis, Steven P., Maranan, Leandro C., Donnino, Robert M., Lorin, Jeffrey, Tamis-Holland, Jacqueline E., Malinay, Ammy, Kornberg, Robert, Leber, Robert, Saba, Souheil, Edillo, Candice P., Lee, Michael W., Small, Delano R., Nona, Wassim, Alexander, Patrick B., Rehman, Iram, Badami, Umesh, Ostrander, Ann, Wasmiller, Stephanie, Marzo, Kevin, Drewes, Wendy, Patel, Dipti, Robbins, Inga H., Levite, Howard A., White, Jackie M, Shetty, Sanjay, Hallam, Alison, Patel, Mayuri, Hamroff, Glenn S., Spooner, Benjamin J, Hollenweger, Linda M, Little, Raymond W., Little, Holly, Zimbelman, Brandi D., Little, Tiffany, Lui, Charles Y., Eskelson, Nona A, Smith, Brigham R., Vezina, Daniel P., Khor, Lillian L., Abraham, Josephine D., Bull, David A., McKellar, Stephen H., Booth, David, Taul, Yvonne, Kotter, John, Rodgers, Caroline, Abdel-Latif, Ahmed, Isaacs, Jennifer, Bulkley, Viktoria, Hu, Bob, Kaneshiro, Renee, Labovitz, Arthur J., Berlowitz, Michael, Kirby, Bonnie J., Rogal, Philip, Tran, Nhi N., McFarren, Christopher, Jahrsdorfer, Catherine, Matar, Fadi, Caldeira, Christiano, Rodriguez, Fatima, Yunis, Reem, Schnittger, Ingela, Patro, Jhina, Fearon, William F., Deedwania, Prakash, Vega, Antonia, Reddy, Kiran, Sweeny, Joseph, Bloise-Adames, Hugo, Jimenez, Santa, Saint Vrestil, Nicole, Bhandari, Reyna, Spizzieri, Christopher, Schade, Danielle, Yost, Roxanne, Hochberg, Claudia P, Beardsley, Paula, Fine, Denise, Salerno, William D., Tancredi, Jana, Arakelian, Patricia, Mathus, Susan, O’Neill, Deborah, Wyman, Ray, Burkhardt, Joy, Hosino, Suellen, Lubyanaya, Oksana A., Salas, Jose D., Zarka, Amer, Aguirre, Maria, Shah, Anil V., Dhawan, Manu, Parra, Diana, Tran, Tri, Haldis, Thomas, Weick, Catherine, Fowler-Lehman, Katie, Spitzer, Natalie, Riedberger, Casey, Weick, Catherine, Kohn, Jeffrey A., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Girotra, Saket, Drum, Carrie, Miller-Cox, Kimberly, Ollinger, Amy, Almousalli, Omar, Capasso-Gulve, Elizabeth, Melanie Loehr, Alaine, Mosley, Marlowe, Krishnam, Mayil S., Heydari, Shirin, Milliken, Jeffrey C., Lundeen, Andrea M., Patel, Pranav M., Karanjah, Edgar, Seto, Arnold H., Marfori, Wanda C., Harley, Kevin T., Hernandez-Rangel, Eduardo, Gibson, Michael A., Singh, Pam, Allen, Byron J., Coram, Rita, Marie Webb, Anne, Fridell, Ellie, Wilson, Heidi, Thomas, Sabu, Kim, Angela, Schwartz, Ronald G, Wilmot, Patrick, Chen, Wei, El Shahawy, Mahfouz, Stevens, Ramona, Stafford, James, Black, Loriane, Abernethy, William B., Hull, Amber B., Lim, Olivia J., Tucker, Helen C., Putnam, Natasha C., Hall, Linda L., Cauthren, Tia, Tucker, Trish, Zurick, Andrew, Horton, Hollie, Orga, Jan, Meyer, Thomas M., White, Joyce R., Morford, Ronald G., Baumann, Cynthia, Rutkin, Bruce, Seeratan, Vidya, Bokhari, Sabahat, Jimenez, Magnolia, Sokol, Seth I., Schultz, Cidney, Meisner, Jay, Russo, Jeanne, Hamzeh, Ihab, Misra, Arunima, Huda, Zohra, Wall, Matthew, Boan, Araceli, Lenges De Rosen, Veronica, Alam, Mahboob, Turner, Michael C., Hinton, Christine R, Mulhearn, Thomas J., Good, Arnold P., Archer, Beth A., Dionne, Julia S., Allardyce, Cheryl A., Sikora, Lindsey N., Czerniak, Jennifer H., Mull, Jennifer A., Ferguson, Elizabeth, Laube, Frances, Shammas, Nicolas W., Shammas, Gail A, Christensen, Lori, Park, Holly, Chilton, Robert, Hecht, Joan, Nguyen, Patricia K., Vo, Davis, Hirsch, James, Jezior, Matthew, Bindeman, Jody, Salkind, Sara, Espinosa, Dalisa, Desimone, Lori-Ann, Gordon, Paul C., Felix-Stern, Lina, Crain, Thomas, Gomes, Jassira, Gordon, Catherine, Stenberg, Robert, Mann, Aimee, McCreary, Theresa, Pedalino, Ronald P., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Wiesel, Joseph, Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Juang, George J., Gopaul, Candace, Hultberg, Karen, Huk, Tauqir, Hussain, Afshan, Al-Amoodi, Mohammed, Zambrano, Yesenia, Medina Rodriguez, Sarah, Milner, Trudie, Wohns, David, Mulder, Abbey, Van Oosterhout, Stacie, Lader, Ellis W., Meyer, Martha, Mumma, Michael, Clapp, Nancy L., Barrentine, Heather, Dharmarajan, Lekshmi, Jose, Jenne M., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Manchery, Jenne, McGarvey Jr, Joseph F.X., McKinney, Vera, Schwarz, Linda, Downes, Thomas R., Kaczkowski, Scott M., Luckasen, Gary J., Jaskowiak, Adam J., Klitch, Joel, Cheong, Benjamin, Dees, Debra, Potluri, Srinivasa, Vasquez, Precilia, Mastouri, Ronald A., Breall, Jeffery A., Hannemann, Elise L., Revtyak, George E., Mae Foltz, Judy, Bazeley, Jonathan W., Li, Dayuan, DeRosa, Emily, Jorgenson, Beth, Riestenberg-Smith, Joyce, Giedd, Kenneth, Old, Wayne, Bariciano, Rebecca, Burt, Francis, Sokhon, Kozhaya, Waldron, Jessica, Mayon, Michelle, Gopal, Deepika, Valeti, Uma S., Ann Peichel, Gretchen, Kobashigawa, Jon, Starks, Brandy, Garcia, Lucilla, Thottam, Maria, Bhargava, Balram, Anand, Anjali, Chakanalil Govindan, Sajeev, Raj, Janitha, Gopalan Nair, Rajesh, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Moorthy, Nagaraja, Nayak, Soundarya, Mylarappa, Mahevamma, Narayanappa, Suryaprakash, Pandit, Neeraj, Bajaj, Sheromani, Kumar Nath, Ranjit, Yadav, Vandana, Mishra, Girish, Dwivedi, S.K., Tewari, Roma, Narain, V.S., Mishra, Meenakshi, Chandra, Sharad, Patel, Shivali, Singh, Suman, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Kaur, Baljeet, Aslam, Naved, Gupta, Sonika, Goyal, Abhishek, Bhargava, Balram, Suvarna, Chandini, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V K, Mathew, Anoop, Mannekkattukudy Kurian, Binoy, Punnoose, Eapen, Avdhoot Gadkari, Milind, Rupesh Karwa, Sheetal, Gadage, Siddharth, Kolhe, Suvarna, Umesh Pillay, Tapan, Satheesh, Santhosh, Vindhya, R. J., Jain, Peeyush, Seth, Ashok, Singh Meharwal, Zile, Mathur, Atul, Verma, Atul, Kaul, Upendra, Bhatia, Mona, Sachdeva, Ankush, Indira Devi, Thounaojam, Jungla, Nungshi, Christopher, Johann, Manjula Rani, K., Menon, Rajeev, Sowjanya Reddy, M., Kumar, Nirmal, Preethi, K., Oomman, Abraham, sidh, Rinu R, Mao, Robert, Ramakrishnan, T., Solomon, Hilda, Francis, Rajesh, Naik, Sudhir, Vamshi, Priya P., Parveen Khan, Sajeeda, Christopher, Johann, Preethi, Kotiboinna, Kumar, Nirmal, Grant, Purvez, Hande, Shweta, Sonawane, Poonam, Kachru, Ranjan, Dubey, Abhishek, Rawat, Kavita, Kumar, Ajit, Ganapathi, Sanjay, K, Jayakumar, CP, Vineeth, Sivadasanpillai, Harikrishnan, Chacko, Manas, Sasidharan, Bijulal, Babu, Suresh, TR, Kapilamoorthy, Christopher, Johann, Reddy, Sowjanya, Polamuri, Praneeth, Rani, Manjula, Kaul, Upendra, Arambam, Priyadarshani, Singh, Bebek, Senior, Roxy, Fox, Keith AA, Young, Grace M., Carruthers, Kathryn, Senior, Roxy, Elghamaz, Ahmed, Gurunathan, Sothinathan, Karogiannis, Nikolaos, Young, Grace M., Shah, Benoy N, Kinsey, Christopher, Trimlett, Richard HJ, Kavalakkat, Raisa, Rubens, Michael B, Evans, Jo, Nicol, Edward D, Hassan, Ikraam, Mittal, Tarun K, Hampson, Reinette, Andreas Gamma, Reto, Williams, Sarah, Holland, Kim, Swan, Karen, de Belder, Mark A, Atkinson, Bev, Thambyrajah, Jeet, Kunhunny, Swapna, Davies, John R, Lindsay, Steven J., Atkinson, Craig, Kurian, John, Krannila, Carita, Jamil, Haqeel, Vinod, Manitha, Raheem, Osama, Hoye, Angela, Chaytor, Lisa, Cox, Leanne, Morrow, Julie, Rowe, Kay, Donnelly, Patrick, Kelly, Stephanie, Valecka, Bernardas, Regan, Susan, Turnbull, Dawn, Chauhan, Anoop, Fleming, Catherine, Ghosh, Arijit, Gratrix, Karen, Preston, Stephen, Barr, Craig, Cartwright, Anne, Alfakih, Khaled, Knighton, Abigail, Byrne, Jonathan, Martin, Katherine, Webb, Ian, Henriksen, Peter, Flint, Laura, Harrison, James, OKane, Peter, Lakeman, Nicki, Ljubez, Anja, de Silva, Ramesh, Conway, Dwayne S. G., Wright, Judith, Exley, Donna, Sirker, Alexander A, Andiapen, Mervyn, Richards, Amy J., Hoole, Stephen P, Wong, Lisa, Witherow, Fraser N., Munro, Melanie J., Johnston, Nicola, Harbinson, Mark, McEvoy, Michelle, Walsh, Simon, Brown, Caroline, Douglas, Hanna, Luckie, Matthew, Charles, Thabitha, Kolakaluri, Laurel, Phillips, Hannah, Sobolewska, Jolanta, Morby, Louise, Hallett, Karen, Corbett, Carolyn, Winstanley, Lynne, Jeetley, Paramjit, Smit, Angelique, Patel, Niket, Kotecha, Tushar, Travill, Christopher, Gent, Susan, Karimullah, Iqbal, Hussain, Nafisa, Al-Bustami, Mahmud, Braganza, Denise, Haines, Fiona, Taaffe, Joanne, Henderson, Robert, Burton, Jane, Pointon, Kate, Colton, Maria, Naik, Surendra, King, Rachel, Mathew, Thomas, Brown, Ammani, Docherty, Andrew, Berry, Colin, McCloy, Lisa, Collison, Damien, Robb, Kate, Roditi, Giles, Paterson, Craig, Crawford, Wenda, Kelly, Joanne, McGregor, Lorraine, Moriarty, Andrew J, Mackin, Anne, Glover, Jason D., Knight, Janet P, Pradhan, Jiwan, Mikhail, Ghada, Bose, Tuhina, Francis, Darrel P., Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Gosselin, Gilbert, Proietti, Anna, Brousseau, Myriam, Corfias, Magalie, Blaise, Patricia, Harvey, Luc, Diaz, Ariel, Rheault, Philippe, Barrero, Miguel, Gagné, Carl-Éric, Alarie, Patricia, Pépin-Dubois, Yanek, Arcand, Linda, Costa, Ricardo, Roy, Isabelle, Tung Sia, Ying, Montpetit, Estelle, Lemay, Catherine, Gisbert, Alejandro, Gervais, Pierre, Rheault, Alain, Drouin, Katia, Carl Phaneuf, Denis, Bergeron, Christine, Gosselin, Gilbert, Shelley, Christine, Masson, Christine, Garg, Pallav, Carr, Sandy, Bone, Catherine, Chow, Benjamin J.W., Moga, Ermina, Hessian, Renee C., Kourzenkova, Janetta, Beanlands, Rob S., Walter, Olga, Davies, Richard F., Bainey, Kevin R., Hogg, Norma, Welsh, Suzanne, Cheema, Asim N., Bagai, Akshay, Wald, Ron, Goodman, Shaun, Kushniriuk, Khrystyna, Joseph Graham, John, Hussain, Mohammed, Peterson, Mark, Bello, Olugbenga, Chow, Chi-Ming, Abramson, Beth, Nazir Cheema, Asim, Syed, Ishba, Hussain, Mohammed, Kushniriuk, Khrystyna, Cha, James, Otis, Judy, Otis, Rebecca, Howarth, Andrew G, Seib, Michelle M, Rivest, Sandra M, Sandonato, Rosa, Wong, Graham, Chow, Jackie, Starovoytov, Andrew, Uchida, Naomi, Meadows, Ngaire, Uxa, Amar, Asif, Nadia, Tavares, Suzana, Galiwango, Paul, Bozek, Bev, Kassam, Saleem, Shier, Maria, Mukherjee, Ashok, Larmand, Lori-Ann, Ricci, A. Joseph, Janmohamed, Amir, Hart, Brenda, Lam, Andy, Marucci, Jane, Tai, Sharon, Mehta, Shamir, Brons, Sonya, Beck, Chris, Wong, Glenda, Etherington, Krystal, Arumairajah, Thippeekaa, Udell, Jacob, Aprile, Maria, Karlsson, Sara, Webber, Susan, Généreux, Philippe, Mercure, Chantale, Hameed, Adnan, Aedy, Nancy, Daba, Ledjalem, Farquharson, Fran, Siddiqui, Anam, Carlos Carvalho, Antonio, Lopes, Renato D., Hueb, Whady, Emy Takiuti, Myrthes, Cury Rezende, Paulo, Eustáquio Ribeiro Silva, Expedito, Ciappina Hueb, Alexandre, Pizzol Caetano, Leonardo, Schaan de Quadros, Alexandre, Abdala Karam Kalil, Renato, Peixoto Deiro, Aline, Luiz da Costa Vieira, José, Manica Muller, Alice, Antonieta Pereira de Moraes, Maria, Píccaro de Oliveira, Pedro, Maria Ascoli, Bruna, Bridi, Leonardo, Zottis Poletti, Sílvia, Savaris, Simone, Vitola, João V, Cerci, Rodrigo J, Zier, Sandra S., Farias, Fabio R, Veiga Jr, Vilmar, Fernandes, Miguel M, Antonio Marin-Neto, José, Schmidt, André, de Oliveira Lima Filho, Moysés, Franca da Cunha, Diego, Mendes Oliveira, Ricardo, Reynaldo Abbud Chierice, João, Polanczyk, Carísi A., Rucatti, Guilherme G, Furtado, Mariana V., Igansi, Fernanda, Smidt, Luis F., Haeffner, Mauren P, Carlos Carvalho, Antonio, Almeida, Viviane, Pucci, Gustavo, Sanchez de Souza, Gabriela, Lyra, Flavio, Rabelo Alves Junior, Alvaro, Almeida, Mayana, dos Santos, Viviane, Dracoulakis, Marianna D. A., Oliveira, Natalia S, Lima, Rodolfo G. S. D, Figueiredo, Estevao, Edilena Paulino Azevedo, Bruna, Ricardo Caramori, Paulo, Bizzaro Santos, Marco, Germann, Amanda, Gomes, Vitor, Homem, Rosa, Magedanz, Ellen, Tumelero, Rogerio, Laimer, Rosane, Tognon, Alexandre, Dall’Orto, Frederico, Mesquita, Claudio T., Santos, Roberta P, Colafranseschi, Alexandre S., Oliveira, Amarino C., Carvalho, Luiz A., Palazzo, Isabella C., Sousa, Andre S., Eustáquio Ribeiro da Silva, Expedito, Gabriel Melo de Barros e Silva, Pedro, Yumi Okada, Mariana, de Pádua Silva Baptista, Luciana, Paula Batista, Ana, Jamus Rodrigues, Marcelo, Nogueira Rabaça, Aline, Valério Coimbra de Resende, Marcos, Francisco Saraiva, Jose, Miranda Trama, Larissa, Silva, Talita, Thais de Souza Ormundo, Camila, Vicente, Carla, Costantini, Costantino, Pinheiro, Caroline, Komar, Daniele, Szwed, Hanna, Demkow, Marcin, Kepka, Cezary, Teresinska, Anna, Walesiak, Olga, Kryczka, Karolina, Malinowska, Katarzyna, Henzel, Jan, Solecki, Mateusz, Kaczmarska, Edyta, Mazurek, Tomasz, Maksym, Jakub, Wojtera, Karolina, Fojt, Anna, Szczerba, Ewa, Drozdz, Jaroslaw, Czarniak, Bartosz, Frach, Malgorzata, Szymczyk, Konrad, Niedzwiecka, Iwona, Sobczak, Sebastian, Ciurus, Tomasz, Jakubowski, Piotr, Misztal-Teodorczyk, Magdalena, Teodorczyk, Dawid, Swiderek, Marta, Fratczak, Aleksandra, Wojtala, Ewelina, Szkopiak, Marcin, Lebioda, Patrycja, Wlodarczyk, Michal, Plachcinska, Anna, Kusmierek, Jacek, Miller, Magdalena, Marciniak, Halina, Wojtczak-Soska, Karolina, Łuczak, Katarzyna, Tarchalski, Tomasz, Cichocka-Radwan, Anna, Szwed, Hanna, Karwowski, Jaroslaw, Anna Szulczyk, Grazyna, Witkowski, Adam, Kukuła, Krzysztof, Celińska-Spodar, Małgorzta, Zalewska, Joanna, Gajos, Grzegorz, Bury, Krzysztof, Pruszczyk, Piotr, Łabyk, Andrzej, Roik, Marek, Szramowska, Agnieszka, Zdończyk, Olga, Łoboz-Grudzień, Krystyna, Jaroch, Joanna, Sokalski, Leszek, Brzezińska, Barbara, Lesiak, Maciej, Łanocha, Magdalena, Reczuch, Krzysztof W., Kolodziej, Adam, Kalarus, Zbigniew, Swiatkowski, Andrzej, Szulik, Mariola, Musial, Wlodzimierz J., Marcinkiewicz-Siemion, Marta, Bockeria, Olga, Bockeria, Leo, Bockeria, Olga, Petrosyan, Karen, Kudzoeva, Zalina, Trifonova, Tatiana, Aripova, Nodira, Chernyavskiy, Alexander M., Naryshkin, Ivan A., Kretov, Evgeniy I., Kuleshova, Alena, Grazhdankin, Igor O., Malaev, Dastan, Bershtein, Leonid L., Sayganov, Sergey A., Subbotina, Irina, Kuzmina-Krutetskaya, Anastasia M., Gumerova, Victoria, Zbyshevskaya, Elizaveta V., Katamadze, Nana O., Nikolaeva, Olga B., Kozlov, Pavel S., Kozulin, Vikentiy Y., Lubinskaya, Ekaterina I., Luis Lopez-Sendon, Jose, Castro, Almudena, Lopez-Sendon, Jose, Fernández-Figares, Virginia, Castro, Almudena, Refoyo Salicio, Elena, Guzman, Gabriela, Galeote, Gabriel, Valbuena, Silvia, Peteiro, Jesús, Dolores Martínez-Ruíz, María, Pérez-Fernández, Ruth, Blanco-Calvo, Moisés, Cuenca-Castillo, José J, Alonso-Álvarez, Encarnación, Flores-Ríos, Xacobe, García-González, Paula, Prada-Delgado, Óscar, Barge-Caballero, Gonzalo, Ramon Gonzalez Juanatey, Jose, Seijas Amigo, Jose, Souto Bayarri, Miguel, Pubull Nuñez, Virginia, Ocaranza Sanchez, Raymundo, Cid Alvarez, Belen, Peña Gil, Carlos, Martinez Monzonis, Amparo, Sionis, Alessandro, Fernández Martínez, Ana, Vila Perales, Montserrat, Maria Padró, Josep, Serra Peñaranda, Antonio, García Picart, Joan, Ginel Iglesias, Antonino, Garcia-Moll Marimon, Xavier, Pons Lladó, Guillem, Carreras Costa, Francesc, Miro, Vicente, Igual, Begoña, Diez, Jose L, Calvillo, Pilar, Ortuño, F. Marin, Valdés Chávarri, M., Quintana Giner, M., Tello Montolliu, A., Romero Aniorte, A.I., Pinar Bermudez, E., Rivera Caravaca, JM., De La Morena, G., Gracida Blancas, Montserrat, Cañavate, Olga, Guerrero, Sonia, Riera, Silvia, Enrique Castillo Luena, Jose, Enrique Castillo Luena, Jose, Lasala, Maria, Fernandez-Aviles, Francisco, Lorenzo, Maria, Sobrino, Olga, Vazquez, Alexandra, Jiang, Lixin, Chen, Jiyan, Dong, Haojian, He, Peiyu, Xia, Chunli, Yang, Junqing, Zhong, Qi, Wu, Yongjian, Tian, Yanmeng, Li, Dongze, Ma, Yitong, Li, Xiaomei, Yang, Yining, Ma, Xiang, Yu, Zixiang, Zhao, Qian, Ji, Zheng, Li, Chunguang, Zhang, Lei, Zhao, Yu, Zhu, Bolin, Yang, Xinchun, Chen, Mulei, Chi, Hongjie, Wang, Yang, Zhang, Jing, Lin, Wenhua, Jing, Rui, Liu, Jingjing, Zeng, Hesong, Zhou, Qiang, Xu, Chang, Li, Zhuxi, Li, Junhua, Xiong, Luyang, Fu, Xin, Gao, Dan, Jiang, Dengke, Leng, Ran, Wang, Xutong, Yuan, Qianqian, Zhang, Lili, Yang, Bin, Bai, Ziliang, Li, Jianhua, Qi, Jie, Wang, Fei, Wang, Haitao, Yang, Bin, Yue, Zhou, Zhang, Zhulin, Wang, Songtao, Dong, Yumei, Mao, Jiajia, Zhang, Bin, Cheng, Gong, Li, Xiuhong, Yao, Xiaowei, Zhong, Nier, Zhou, Ning, Zhao, Yulan, Huang, Yaping, Zhou, Panpan, Fang, Xuehua, Su, Wei, Zeng, Qiutang, Kunwu, Yu, Peng, Yudong, Su, Xin, Su, Xi, Wang, Chen, Zhao, Yunhai, Li, Qingxian, Geng, Yaming, Wang, Yanfu, Nie, Shao-ping, Fan, Jing-yao, Feng, Si-ting, Wang, Xiao, Yan, Yan, Zhang, Hui-min, Yu, Qin, Chi, Lingping, Liu, Fang, Wang, Jian’an, Chen, Han, Jiang, Jun, Li, Huajun, Wang, Jian’an, Han, Yechen, Xu, Lihong, Zhang, Shuyang, Liu, Zhenyu, Liu, Zhenyu, Chen, Gang, Hu, Rongrong, Maggioni, Aldo P., Piero Perna, Gian, Pietrucci, Francesca, Marini, Marco, Gabrielli, Gabriele, Provasoli, Stefano, Di Donato, Anna, Verna, Edoardo, Monti, Lorenzo, Nardi, Barbara, Di Chiara, Antonio, Pezzetta, Francesca, Mortara, Andrea, Casali, Valentina, Galvani, Marcello, Attanasio, Chiara, Ottani, Filippo, Sicuro, Marco, Leone, Gianpiero, Pisano, Francesco, Bare, Cristina, Calabro, Paolo, Fimiani, Fabio, Formisano, Tiziana, Tarantini, Giuseppe, Barioli, Alberto, Cucchini, Umberto, Ramani, Federica, Luigi Andres, Anto, Racca, Emanuela, Rolfo, Fabrizio, Goletto, Cecilia, Briguori, Carlo, De Micco, Francesca, Amati, Roberto, Di Marco, Stefano, Vergoni, William, Tricoli, Martina, Russo, Aldo, Villella, Massimo, Fanelli, Raffaele, Douglas White, Harvey, Alsweiler, Caroline, Poh, Kian-Keong, Chai, Ping, Lau, Titus, Loh, Joshua P., Tay, Edgar L., Teoh, Kristine, Tan, Sik-Yin V, Teo, Lynette L., Sia, Winnie C, Ong, Ching-Ching, Leong, Audrey W, Wong, Raymond C., Loh, Poay-Huan, Kofidis, Theodoros, Xian Chan, Wan, Hui Chan, Koo, Foo, David, Hai Yan, Li, Loh Kwok Kong, Jason, Min Er, Ching, Haider Jafary, Fahim, Chua, Terrance, Ismail, Nasrul, Tun Kyaw, Min, Yip, Deborah, Doerr, Rolf, Doerr, Rolf, Stumpf, Juergen, Grahl, Dorit, Matschke, Klaus, Guenther, Franziska, Simonis, Gregor, Bonin, Kerstin, Kadalie, Clemens T., Sechtem, Udo, Wenzelburger, Ina, Ong, Peter, Gruensfelder, Susanne, Christian Schulze, P., Goebel, Bjoern, Lenk, Karsten, Nickenig, Georg, Sinning, Jan-Malte, Weber, Marcel, Werner, Nikos, Marthe Lang, Irene, Huber, Kurt, Schuchlenz, Herwig, Steinmaurer, Gudrun, Weikl, Stefan, Marthe Lang, Irene, Winter, Max-Paul, Andric, Tijana, Huber, Kurt, Tscharre, Maximilian, Jakl-Kotauschek, Gabriele, Wegmayr, Claudia, Jäger, Bernhard, Egger, Florian, Keltai, Matyas, Vertes, Andras, Sebo, Judit, Davidovits, Zoltan, Matics, Laszlone, Varga, Albert, Ágoston, Gergely, Fontos, Geza, Dekany, Gabor, Merkely, Bela, Bartykowszki, Andrea, Maurovich-Horvat, Pal, Kerecsen, Gabor, Jakal, Agnes, Hinic, Sasa, Djokic, Jelena, Zdravkovic, Marija, Mudrenovic, Vladan, Crnokrak, Bogdan, Beleslin, Branko D., Boskovic, Nikola N., Djordjevic-Dikic, Ana D., Petrovic, Marija T., Giga, Vojislav L., Dobric, Milan R., Stepanovic, Jelena J., Markovic, Zeljko Z., Mladenovic, Ana S., Cemerlic-Adjic, Nada, Velicki, Lazar, Kamenica, Sremska, Pupic, Ljiljana, Davidović, Goran, Simović, Stefan M., Vučić, Rada, Dekleva, Milica Nikola, Martinovic, Miroslav Stevo, Stevanovic, Gordana, Stankovic, Goran, Dobric, Milan, Apostolovic, Svetlana, Martinovic, Sonja Salinger, Stanojevic, Dragana, Escobedo, Jorge, Jesús-Pérez, Ramon de, Juarez, Benito, Baleón-Espinosa, Rubén, Campos-Santaolalla, Arturo S, Durán-Cortés, Elihú, Flores-Palacios, José M, García-Rincón, Andrés, Jiménez-Santos, Moisés, Peñafiel, Joaquín V, Ortega-Ramírez, José A, Valdespino-Estrada, Aquiles, Rosas, Erick Alexánderson, Canales Brassetti, María Fernanda, Vences Anaya, Diego Adrián, García, María Pérez, Carvajal Juarez, Isabel Estela, Rovalo, Magdalena Madero, Morales Rodríguez, Erick Donato, Selvanayagam, Joseph B., Rankin, Jamie, Murphy, Deirdre, Selvanayagam, Joseph B., Lee, Sau, Joseph, Majo X., Thomas, Prince, Thambar, Suku T., Chaplin, Melissa D, Boer, Stephanie C, Beltrame, John F., Stansborough, Jeanette K., Black, Marilyn, Hillis, Graham S., Bonner, Michelle M., Ireland, Kim F., Venn-Edmonds, Clare, Steg, Philippe-Gabriel, Abergel, Helene, Juliard, Jean-Michel, Thobois, Corine, Pasteur, C.H. Louis, Thuaire, Christophe, Tachot, Emilie, Dutoiu, Téodora, Laure, Christophe, Vassaliere, Christel, Steg, Philippe Gabriel, Abergel, Helene, Juliard, Jean-Michel, Fuentes, Axelle, Slama, Michel S., Eliahou, Ludivine, Cedex, Clamart, El Mahmoud, Rami, Dubourg, Olivier, Michaud, Pierre, Nicollet, Eric, Hadjih, Sarah, Cedex, Corbeil-Essonnes, Goube, Pascal, Brito, Patricia, Barone-Rochette, Gilles, Barone-Rochette, Gilles, Furber, Alain, Cornet, Charles, Bière, Loïc, Rautureau, Jeremy, Juceviciene, Agne, Kalibataite-Rutkauskiene, Irma, Keinaite, Laura, Laucevicius, Aleksandras, Laukyte, Monika, Celutkiene, Jelena, Mikolaitiene, Gelmina, Smigelskaite, Akvile, Tamasauskiene, Ilona, Urboniene, Agne, Kedhi, Elvin, Klinieken, Isala, Timmer, Jorik, Bouwhuis, Ilse, Hermanides, Rik, Nijmeijer, Lia, Kaplan, Eliza, Riezebos, Robert K., Samadi, Pouneh, Schoep Jeannette, J. M., Dongen, Elise van, Janzen, Elisabeth M., Niehe, Sander R., Suryapranata, Harry, Ahoud, Sandra, Vugt, Stijn van, Ramos, Ruben, Santa Marta, Hospital de, Cacela, Duarte, Santana, Ana, Fiarresga, Antonio, Sousa, Lidia, Marques, Hugo, Patricio, Lino, Selas, Mafalda, Bernanrdes, Luis, Silva, Filipa, Rio, Pedro, Freixo, Cláudia, Carvalho, Ramiro, Ferreira, Rui, Silva, Tiago, Rodrigues, Ines, Modas, Pedro, Portugal, Guilherme, Fragata, Jose, Pinto, Fausto J., Cabrita, Inês Zimbarra, Menezes, Miguel Nobre, Rocha, Andreia, Lopes, Guilhermina Cantinho, Figueiras, Francisca Patuleia, Almeida, Ana Gomes, Coelho, Andreia, CanVas Silva, Pedro, Capinha, Marta, Nobre, Angelo, Caetano, Maria Inês, Francisco, Ana Rita, Silva, Susana, Ferreira, Nuno, de Gaia, Vila Nova, Lopes, Ricardo L., Diaz, Rafael, Guzman, Luis, Tinnirello, Veronica, Figal, Julio César, Nicolás Mungo, Matías, Buenos Aires, Ciudad Autonoma de, Méndiz, Oscar, Cortés, Claudia, Favaloro, Roberto René, Alvarez, Carlos, Garcia, Marina, Blanca, Bahia, Courtis, Javier, Godoy, Valeria, Zeballos, Gabriela, Schiavi, Lilia, Actis, Maria Victoria, Rubio, Mariano, Scaro, Graciela, White, Harvey Douglas, Alsweiler, Caroline, Devlin, Gerard Patrick, Low, Liz, Fisher, Raewyn, Scales, Jayne, Abercrombie, Kirsty, Stewart, Ralph Alan Huston, Howell, Leah, White, Harvey Douglas, Patten, Cathrine, Benatar, Jocelyne, Kedev, Sasko, Mitevska, Irena Peovska, Kostovska, Elizabeta Srbinovska, Pejkov, Hristo, Held, Claes, Held, Claes, Eggers, Kai, Frostfelt, Gunnar, Björklund, Christina, Johnston, Nina, Andreasson, Maria, Olsowka, Maciej, Essermark, Marie, Åkerblom, Axel, Soveri, Inga, Aspberg, Johannes, Persson, Liselotte, Beyar, Rafael, Sharir, Tali, Nikolsky, Eugenia, Sharir, Tali, Harel, Or, Elian, Dan, Kerner, Arthur, Bentzvi, Margalit, Massalha, Samia, Helmer, Ludmila, Kohsaka, Shun, Fukuda, Keiichi, Ueda, Ikuko, Kohsaka, Shun, Fujita, Jun, Yasuda, Satoshi, Furukawa, Akemi, Hirase, Kanae, Nagai, Toshiyuki, Otsuka, Fumiyuki, Nishimura, Shigeyuki, Nakano, Shintaro, de Werf, Frans Van, Goetschalckx, Kaatje, Goetschalckx, Kaatje, Robesyn, Valerie, de Werf, Frans Van, Claes, Kathleen, White, Harvey Douglas, Alsweiler, Caroline, Hung, Chung-Lieh, Yang, Yi-Hsuan, Yun, Chun-Ho, Hou, Charles Jia-Yin, Kuo, Jen-Yuan, Yeh, Hung-I, Hung, Ta-Chuan, Li, Jiun-Yi, Chien, Chen-Yen, Tsai, Cheng-Ting, Liu, Chun-Chieh, Yu, Fa-Chang, Lin, Yueh-Hung, Lan, Wei-Ren, Yen, Chih-Hsuan, Tsai, Jui-Peng, Sung, Kuo-Tzu, Ntsekhe, Mpiko, Pandie, Shaheen, Philander (Nee Talliard), Constance, Viljoen, Charle A, Mtana, Noloyiso, De Andrade, Marianne, Maggioni, Aldo P., Moccetti, Tiziano, Anesini, Adriana, Rossi, M.Grazia, Maspoli, Simona, Mombelli, Manuela, Abdelhamid, Magdy, Talaat, Ahmed, Adel, Ahmed, Kamal, Ahmed, Mahrous, Hossam, Kaffas, Sameh El, Fishawy, Hussien El, Pop, Calin, Claudia, Matei, Popescu, Bogdan A., Ginghina, Carmen, Rosca, Monica, Deleanu, Dan, Beladan, Carmen C., Iliescu, Vlad A., Al-Mallah, Mouaz H., Zahrani, Sarah, Aljzeeri, Ahmed, Najm, Hani, Alghamdi, Ali, Mogrovejo Ramos, Walter Enrique, Monsalve Davila, Marco Antonio, White, Harvey Douglas, Alsweiler, Caroline, Kuanprasert, Srun, Mai, Chiang, Prommintikul, Arintaya, Nawarawong, Weerachai, Khwakhong, Supatchara, Woragidpoonpol, Surin, Chaiyasri, Anong, Tepsuwan, Thitipong, Mekara, Warangkana, Taksaudom, Noppon, Kulthawong, Supap, Rimsukcharoenchai, Chataroon, Amaritakomol, Anong, Euathrongchit, Juntima, Wannasopha, Yutthaphan, Yamwong, Sukit, Panpunuan, Pachara, Sritara, Piyamitr, Aramcharoen, Suthara, Meemuk, Krissada, White, Harvey Douglas, Alsweiler, Caroline, Khairuddin, Ahmad, Mokhtar, Noor Syamira, Hadi, Hafidz Abd, Basri, Nor Asiah, Yahaya, Shaiful Azmi, Yusnida, Irni, Hashim, Humayrah, Harrington, Robert, Williams, David, Alexander, Karen P., Berger, Jeffrey, Harrington, Robert, Mark, Daniel, O’Brien, Sean M., Rosenberg, Yves, Shaw, Leslee J., Ballantyne, Christie, Berman, Daniel, Beyar, Rafael, Bhargava, Balram, Buller, Chris, (Tony) Carvalho*, Antonio, Chaitman, Bernard R., Diaz, Rafael, Doerr, Rolf, Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Hachamovitch, Rory, Hamm, Christian, Held, Claes, Helm, Malte, Huber, Kurt, Jiang, Lixin, Keltai, Matyas, Kohsaka, Shun, Lang, Irene, Lopes, Renato, Lopez-Sendon, Jose, Maggioni, Aldo, Bairey Merz, C. Noel, Min, James, Peterson, Eric, Picard, Michael H., Selvanayagam, Joseph, Senior, Roxy, Sharir, Tali, Steg, Gabriel, Szwed, Hanna, de Werf, Frans Van, Weintraub, William, White, Harvey, Williams, David, Ballantyne, Christie, Calfas*, Karen, Chaitman, Bernard R., Champagne, Mary Ann, Davidson, Michael, Fleg, Jerome, McCullough, Peter A., Stone, Peter, Menasche, Philippe, Davidson*, Michael, Fremes, Stephen, Guyton, Robert, Mack, Michael, Mohr, Fred, Rao, Anupama, Sabik, Joe, Shapira, Oz, Taggart, David, Tatoulis, James, Williams, David, Blankenship, Jim, Brener, Sorin, Buller, Chris, Colombo, Antonio, Bruyne, Bernard de, Généreux, Philippe, Harrington, Robert, Kereiakes, Dean, Lefevre, Thierry, Moses, Jeffrey, Chaitman, Bernard R., Alexander, Karen P., Mahaffey, Ken, White, Harvey, Chaitman, Bernard R., Cruz-Flores, Salvador, Danchin, Nicholas, Feen, Eli, Garcia, Mario J., Hauptman, Paul, Laddu, Abhay A., Passamani, Eugene, Pina, Ileana L., Simoons, Maarten, Skali, Hicham, Thygesen, Kristian, Waters, David, Alexander, Karen P., Endsley, Patricia, Esposito, Gerard, Kanters, Jeffrey, Pownall, John, Stournaras, Dimitrios, Shaw, Leslee J., Berman, Daniel, Friedrich, Matthias, Hachamovitch, Rory, Kwong, Raymond, Min, James, Oliver, Dana, Picard, Michael H., Harrell, Frank, Blume, Jeffrey, Lee, Kerry, O’Brien, Sean M., Berger, Jeffrey, Held, Claes, Kullo, Iftikhar, McManus, Bruce, Newby, Kristin, Mark, Daniel, Cohen, David, Weintraub, William, Merz, C. Noel Bairey, Bugiardini, Raffaele, Celutkiene, Jelena, Escobedo, Jorge, Hoye, Angela, Lyubarova, Radmila, Mattina, Deirdre, Peteiro, Jesus, Alexander, Karen P., Berger, Jeffrey, Harrington, Robert, O’Brien, Sean M., Rosenberg, Yves, Mark, Daniel, Mark, Daniel, Shaw, Leslee J., Berman, Dan, Chaitman, Bernard R., Fleg, Jerome, Kwong, Raymond, Picard, Michael H., Senior, Roxy, Min, James, Leipsic, Jonathan, Ali, Ziad, Williams, David, Fleg, Jerome, Berger, Jeffrey, Chaitman, Bernard R., Alexander, Karen P., Alexander, Karen P., Fleg, Jerome, Mathew, Roy, O’Brien, Sean M., Sidhu, Mandeep, Friedman, Lawrence, Anderson, Jeffrey, Berg, Jessica, DeMets, David, Gibson, C. Michael, Lamas, Gervasio, Deming, Nicole, Himmelfarb, Jonathan, Ouyang, Pamela, Woodard, Pamela, Harrell, Frank, Nwosu, Samuel, Rosenberg, Yves, Fleg, Jerome, Kirby, Ruth, Jeffries, Neal, Berger, Jeffrey, Sidhu, Mandeep, Denaro*, Jean E., Mavromichalis, Stephanie, Chan, Kevin, Cobb, Gia, Contreras, Aira, Cukali, Diana, Ferket, Stephanie, Gabriel, Andre, Hansen, Antonietta, Roberts, Arline, Chang, Michelle, Islam, Sharder, Wayser, Graceanne, Yakubov, Solomon, Yee, Michelle, Callison, Caroline, Hogan, Isabelle, Qelaj, Albertina, Pirro, Charlotte, Loo, Kerrie Van, Wisniewski, Brianna, Gilsenan, Margaret, Lang, Bevin, Mohamed, Samaa, Esquenazi-Karonika, Shari, Mathews, Patenne, Naumova, Anna, Lyo, Jihyun, Setang, Vincent, Xavier, Mark, O’Brien, Sean M., Alexander, Karen P., Mark, Daniel B., Anstrom, Kevin, Baloch, Khaula, Blount, Janet, Cowper, Patricia, Davidson-Ray, Linda, Drew, Laura, Harding, Tina, Knight, J David, Liu, Diane Minshall, O’Neal, Betsy, Redick, Thomas, Jones, Philip, Nugent, Karen, Wang, Grace Jingyan, Shaw, Leslee J., Phillips, Lawrence, Goyal, Abhinav, Hetrick, Holly, Oliver, Dana, Berman, Daniel, Hayes, Sean W., Friedman, John D., Gerlach, R. James, Hyun, Mark, Miranda-Peats, Romalisa, Slomka, Piotr, Thomson, Louise, Kwong, Raymond Y., Friedrich, Matthias, Mongeon, Francois Pierre, Michael, Steven, Picard, Michael H., Hung, Judy, Scherrer-Crosbie, Marielle, Zeng, Xin, Chaitman, Bernard R., Eckstein, Jane, Guruge, Bandula, Streif, Mary, Ali, Ziad, Genereux, Philippe, Alfonso, Maria A., Corral, Maria P., Garcia, Javier J., Horst, Jennifer, Jankovic, Ivana, Konigstein, Maayan, Lustre, Mitchel B., Peralta, Yolayfi, Sanchez, Raquel, Min, James, Arsanjani, Reza, Budoff, Matthew, Elmore, Kimberly, Gomez, Millie, Hague, Cameron, Hindoyan, Niree, Leipsic, Jonathan, Nakanishi, Rine, Srichai-Parsia, M. Barbara, Yeoh, Eunice, Youn, Tricia, Maggioni, Aldo P., Bianchini, Francesca, Ceseri, Martina, Lorimer, Andrea, Magnoni, Marco, Orso, Francesco, Sarti, Laura, Tricoli, Martinia, Carvalho, Antonio, Lopes, Renato, Barbosa, Lilian Mazza, Duarte, Tauane Bello, Soares, Tamara Colaiácovo, Aveiro Morata, Julia de, Carvalho, Pedro, Carvalho Maffei, Natalia de, Egydio, Flávia, Kawakami, Anelise, Oliveira, Janaina, Piloto, Elissa Restelli, Pozzibon, Jaqueline, Goodman, Shaun, Camara, Diane, Mowafy, Neamat, Spindler, Caroline, Jiang, Lixin, Dai, Hao, Feng, Fang, Li, Jia, Li, Li, Liu, Jiamin, Xie, Qiulan, Zhang, Haibo, Zhang, Jianxin, Zhang, Lihua, Zhang, Liping, Zhang, Ning, Zhong, Hui, Diaz, Rafael, Escobar, Claudia, Martin, Maria Eugenia, Pascual, Andrea, Lopez-Sendon, José, Moraga, Paloma, Hernandez, Victoria, Castro, Almudena, Posada, Maria, Fernandez, Sara, Villanueva, José Luis Narro, Selgas, Rafael, Steg, Gabriel, Abergel, Helene, Juliard, Jean Michel, White, Harvey, Alsweiler, Caroline, de Werf, Frans Van, Claes, Kathleen, Goetschalckx, Kaatje, Luyten, Ann, Robesyn, Valerie, Selvanayagam, Joseph B., Murphy, Deirdre, Ahmed, Asker, Bhatt, Richa, Chadha, Nitika, Kumar, Vijay, Lubna, Sadath, Naik, Pushpa, Pandey, Shruti, Ramasamy, Karthik, Saleem, Mohammed, Sharma, Pratiksha, and Siddaram, Hemalata
- Published
- 2024
- Full Text
- View/download PDF
10. Heart transplant recipient 1-year outcomes during the COVID-19 pandemic.
- Author
-
Esmailian, Gabriel, Patel, Nikhil, Patel, Jignesh, Czer, Lawrence, Rafiei, Matthew, Megna, Dominick, Emerson, Dominic, Ramzy, Danny, Trento, Alfredo, Chikwe, Joanna, Esmailian, Fardad, and Kobashigawa, Jon
- Subjects
COVID-19 ,SARS-CoV-2 ,heart transplantation ,pandemic ,COVID-19 ,Graft Rejection ,Heart Transplantation ,Humans ,Pandemics ,Retrospective Studies ,Transplant Recipients - Abstract
The COVID-19 pandemic initially brought forth considerable challenges to the field of heart transplantation. To prevent the spread of the virus and protect immunocompromised recipients, our center made the following modifications to post-transplant outpatient management: eliminating early coronary angiograms, video visits for postoperative months 7, 9, and 11, and home blood draws for immunosuppression adjustments. To assess if these changes have impacted patient outcomes, the current study examines 1-year outcomes for patients transplanted during the pandemic. Between March and September 2020, we assessed 50 heart transplant patients transplanted during the pandemic. These patients were compared to patients who were transplanted during the same months between 2011 and 2019 (n = 482). Endpoints included subsequent 1-year survival, freedom from cardiac allograft vasculopathy, any-treated rejection, acute cellular rejection, antibody-mediated rejection, nonfatal major adverse cardiac events (NF-MACE), and hospital and ICU length of stay. Patients transplanted during the pandemic had similar 1-year endpoints compared to those of patients transplanted from years prior apart from 1-year freedom from NF-MACE which was significantly higher for patients transplanted during the pandemic. Despite necessary changes being made to outpatient management of heart transplant recipients, heart transplantation continues to be safe and effective with similar 1-year outcomes to years prior.
- Published
- 2022
11. Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival
- Author
-
Halloran, Philip F., Madill-Thomsen, Katelynn, Aliabadi-Zuckermann, Arezu Z., Cadeiras, Martin, Crespo-Leiro, Marisa G., Depasquale, Eugene C., Deng, Mario, Gökler, Johannes, Hall, Shelley, Jamil, Aayla, Kim, Daniel H., Kobashigawa, Jon, Macdonald, Peter, Melenovsky, Vojtech, Patel, Jignesh, Potena, Luciano, Shah, Keyur, Stehlik, Josef, and Zuckermann, Andreas
- Published
- 2024
- Full Text
- View/download PDF
12. Long-term outcomes after heart transplantation using ex vivo allograft perfusion in standard risk donors: A single-center experience.
- Author
-
Chen, Qiudong, Singer-Englar, Tahli, Kobashigawa, Jon, Roach, Amy, Emerson, Dominic, Megna, Dominick, Ramzy, Danny, Catarino, Pedro, Patel, Jignesh, Kittleson, Michelle, Czer, Lawrence, Chikwe, Joanna, and Esmailian, Fardad
- Subjects
heart (allograft) function/dysfunction ,heart disease ,organ perfusion and preservation ,patient survival ,Allografts ,Heart Diseases ,Heart Transplantation ,Humans ,Organ Preservation ,Perfusion ,Tissue Donors - Abstract
INTRODUCTION: The Organ Care System (OCS) is an ex vivo perfusion platform for donor heart preservation. Short/mid-term post-transplant outcomes after its use are comparable to standard cold storage (CS). We evaluated long-term outcomes following its use. METHODS: Between 2011 and 2013, 38 patients from a single center were randomized as a part of the PROCEED II trial to receive allografts preserved with CS (n = 19) or OCS (n = 19). Endpoints included 8-year survival, survival free from graft-related deaths, freedom from cardiac allograft vasculopathy (CAV), non-fatal major adverse cardiac events (NF-MACE), and rejections. RESULTS: Eight-year survival was 57.9% in the OCS group and 73.7% in the CS group (p = .24). Freedom from CAV was 89.5% in the OCS group and 67.8% in the CS group (p = .13). Freedom from NF-MACE was 89.5% in the OCS group and 67.5% in the CS group (p = .14). Eight-year survival free from graft-related death was equivalent between the two groups (84.2% vs. 84.2%, p = .93). No differences in rejection episodes were observed (all p > .5). CONCLUSIONS: In select patients receiving OCS preserved allografts, late post-transplant survival trended lower than those transplanted with an allograft preserved with CS. This is based on a small single-center series, and larger numbers are needed to confirm these findings.
- Published
- 2022
13. Heart transplantation with super-aged donors older than 65 years
- Author
-
Hada, Tasuku, Seguchi, Osamu, Kitahata, Nana, Komeyama, Shotaro, Mochizuki, Hiroki, Watanabe, Takuya, Kainuma, Satoshi, Fukushima, Satsuki, Tsukamoto, Yasumasa, Fujita, Tomoyuki, Kobashigawa, Jon, and Fukushima, Norihide
- Published
- 2024
- Full Text
- View/download PDF
14. Utility of a score-based approach to liver assessment in heart transplant candidates
- Author
-
Rushakoff, Joshua A., Cao, Louie, Ebinger, Joe, Kuo, Alexander, Botting, Patrick, Emerson, Dominic, Countance, Guillame, Lebray, Pascal, Tompkins, Rose, Kobashigawa, Jon A., Patel, Jignesh K., Guindi, Maha, and Kransdorf, Evan P.
- Published
- 2024
- Full Text
- View/download PDF
15. Summary of a consensus conference on heart-liver transplantation
- Author
-
Kobashigawa, Jon, VanWagner, Lisa B., Hall, Shelley, Ardehali, Abbas, Baran, David, Bhimaraj, Arvind, Bonham, Clark Andrew, Breda, Joao Roberto, Chen, Sharon, Czer, Lawrence, Alessandro, David D', Daugherty, Tami, De Marco, Teresa, Emamaullee, Juliet, Emerson, Dominic, Entwistle, John W., Esmailian, Fardad, Estep, Jerry, Gaber, Osama, Ganger, Daniel, Gebel, Howard, Ebel, Noelle Hanako, Harmath, Carla, Heimbach, Julie, Izzy, Manhal, Jackson, Annette, Jeevanandam, Val, Kahn, Jeffrey, Kaldas, Fady, Kamath, Patrick, Kilic, Ahmet, Kittleson, Michelle, Kuo, Alex, Kushwaha, Sudhir, Kwong, Allison, Lewis, Matthew, Loebe, Matthias, Lui, George, Madsen, Joren, McLean, Rhondalyn, Menachem, Jonathan, Mobley, Constance, Mufti, Arji, Patel, Jignesh, Pereira, Naveen, Pinney, Sean, Potter, Lisa, Sack, Jordan, Sahota, Amandeep, Schiano, Thomas D., Schlendorf, Kelly, Shingina, Alexandra, Takeda, Koji, Taner, Timucin, Te, Helen, Teuteberg, Jeffrey, Tompkins, Rose, Verna, Betsy, Wall, Anji, Jeevanandam, Valluvan, Lui, George K., Motayagheni, Negar, Patel, Nikhil, and Sani, Maryam
- Published
- 2024
- Full Text
- View/download PDF
16. Molecular states associated with dysfunction and graft loss in heart transplants
- Author
-
Halloran, Philip F., Madill-Thomsen, Katelynn, Mackova, Martina, Aliabadi-Zuckermann, Arezu Z., Cadeiras, Martin, Crespo-Leiro, Marisa G., Depasquale, Eugene C., Deng, Mario, Gökler, Johannes, Hall, Shelley A., Kim, Daniel H., Kobashigawa, Jon, Macdonald, Peter, Potena, Luciano, Shah, Keyur, Stehlik, Josef, Zuckermann, Andreas, and Reeve, Jeff
- Published
- 2024
- Full Text
- View/download PDF
17. HLA sensitization is associated with an increased risk of primary graft dysfunction after heart transplantation
- Author
-
Han, Jiho, Rushakoff, Josh, Moayedi, Yasbanoo, Henricksen, Erik, Lee, Roy, Luikart, Helen, Shalakhti, Omar, Gragert, Loren, Benck, Lillian, Malinoski, Darren, Kobashigawa, Jon, Teuteberg, Jeffrey, Khush, Kiran K., Patel, Jignesh, and Kransdorf, Evan
- Published
- 2024
- Full Text
- View/download PDF
18. Temporal Trends, Risk Factors, and Clinical Outcomes of De Novo Lymphoproliferative Disorders After Heart Transplantation
- Author
-
Kim, In-Cheol, Kim, Sang Hyun, Youn, Jong-Chan, Kim, Darae, Lee, Seonhwa, Kim, Hyungseop, Kim, Jin-Jin, Jung, Mi-Hyang, Rossano, Joseph W., Cherikh, Wida S., Kobashigawa, Jon A., and Stehlik, Josef
- Published
- 2024
- Full Text
- View/download PDF
19. IgM marks persistent IgG anti-human leukocyte antigen antibodies in highly sensitized heart transplant patients
- Author
-
Li, Fang, Gragert, Loren, Giovanni Biagini, D., Patel, Jignesh K., Kobashigawa, Jon A., Trück, Johannes, Rodriguez, Oscar, Watson, Corey T., Gibb, David R., Zhang, Xiaohai, and Kransdorf, Evan P.
- Published
- 2024
- Full Text
- View/download PDF
20. Heart transplantation in patients from socioeconomically distressed communities
- Author
-
Chen, Qiudong, Malas, Jad, Emerson, Dominic, Megna, Dominick, Catarino, Pedro, Esmailian, Fardad, Chikwe, Joanna, Czer, Lawrence S., Kobashigawa, Jon A., and Bowdish, Michael E.
- Published
- 2024
- Full Text
- View/download PDF
21. The outcome of restrictive cardiac allograft physiology in severe coronary allograft vasculopathy
- Author
-
Tsuji, Masaki, Patel, Jignesh K., Kittleson, Michelle M., Chang, David H., Kransdorf, Evan P., Nikolova, Andriana P., Stern, Lily K., Bhatnagar, Nayana, and Kobashigawa, Jon A.
- Published
- 2024
- Full Text
- View/download PDF
22. Total Artificial Heart as Bridge to Cardiac Retransplantation.
- Author
-
Zadikany, Ronit, Cole, Robert, Chang, David, Patel, Jignesh, Geft, Dael, Czer, Lawrence, Esmailian, Fardad, Ramzy, Danny, Moriguchi, Jaime, Kobashigawa, Jon, and Kittleson, Michelle
- Subjects
Adult ,Female ,Heart Transplantation ,Heart ,Artificial ,Humans ,Male ,Middle Aged ,Reoperation - Abstract
Mechanical circulatory support has been performed as a bridge to cardiac retransplantation in selected patients with graft failure. However, there is limited published experience on the use and potential benefit of the total artificial heart (TAH) as a bridge to cardiac retransplantation. We report on our institutional experience with 3 patients that received TAH as a bridge to retransplant, with 1 patient surviving post-retransplantation. This case series demonstrates the high-risk nature of this undertaking in cardiac retransplant candidates and highlights the issue of sensitization portending greater risk for poor outcomes after TAH as bridge to retransplantation.
- Published
- 2021
23. Trainee experience on ischemic times and outcomes following orthotopic heart transplantation
- Author
-
Roach, Amy, Trento, Alfredo, Peiris, Achille, Kobashigawa, Jon, Esmailian, Fardad, Chikwe, Joanna, and Emerson, Dominic
- Published
- 2023
- Full Text
- View/download PDF
24. The evolving use of biomarkers in heart transplantation: Consensus of an expert panel
- Author
-
Kobashigawa, Jon, Hall, Shelly, Agbor-Enoh, Sean, Bray, Robert, Cadeiras, Martin, Chang, Patty, Chih, Sharon, Eisen, Howie, Farr, Maryjane, Fine, Barry, Ghafourian, Kambiz, Halloran, Phil, Jackson, Annette M, Kao, Andrew, Khush, Kiran K, Madabhushi, Anant, Margulies, Kenneth B, Sani, Maryam Mojarrad, Patel, Jignesh K, Patel, Nikhil, Peyster, Eliot, Parwani, Anil, Pinney, Sean, Schlendorf, Kelley, Shah, Keyur, Shah, Palak, Stehlik, Josef, Tambur, Anat, Zeevi, Adriana, Hall, Shelley, Jackson, Annette M., Khush, Kiran K., Margulies, Kenneth B., and Patel, Jignesh K.
- Published
- 2023
- Full Text
- View/download PDF
25. Successful Treatment of Severe COVID-19 Pneumonia With Clazakizumab in a Heart Transplant Recipient: A Case Report.
- Author
-
Vaidya, Gaurang, Czer, Lawrence, Kobashigawa, Jon, Kittleson, Michelle, Patel, Jignesh, Chang, David, Kransdorf, Evan, Shikhare, Anuja, Tran, Hai, Vo, Ashley, Ammerman, Noriko, Huang, Edmund, Zabner, Rachel, and Jordan, Stanley
- Subjects
Antibodies ,Monoclonal ,Antibodies ,Monoclonal ,Humanized ,Betacoronavirus ,COVID-19 ,Coronavirus Infections ,Humans ,Immunocompromised Host ,Male ,Middle Aged ,Pandemics ,Pneumonia ,Viral ,Receptors ,Interleukin-6 ,SARS-CoV-2 ,COVID-19 Drug Treatment - Abstract
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by an overwhelming cytokine response. Various treatment strategies have been attempted. METHODS AND RESULTS: A 61-year-old man with heart transplantation in 2017 presented with fever, cough, and dyspnea, and was confirmed positive for coronavirus disease 2019 (COVID-19). Laboratory tests showed significant elevations in C-reactive protein and interleukin-6 (IL-6). Echocardiogram showed left ventricular ejection fraction 58% (with ejection fraction 57% 6 months prior). Given the lack of clear management guidelines, the patient was initially managed symptomatically. However, the patient subsequently had a rapid respiratory deterioration with worsening inflammatory markers on day 5 of admission. Tocilizumab (anti-IL-6R) was in low supply in the hospital. The patient was offered clazakizumab (anti-IL-6) for compassionate use. Patient received 25 mg intravenously × 1 dose. Within 24 hours, he showed significant improvement in symptoms, oxygen requirements, radiological findings, and inflammatory markers. There was a transient leukopenia that improved in 4 days. He was discharged home on day 11, with negative nasopharyngeal SARS-CoV-2 PCR as an outpatient on day 35, development of positive serum COVID-19 IgG antibody, and he continued to do well on day 60, with no heart-related symptoms. CONCLUSION: Clazakizumab is a monoclonal antibody against human IL-6, which may be helpful in inhibiting the cytokine response to SARS-CoV-2 in COVID-19. Although not yet FDA approved, it is being investigated for treatment of renal antibody-mediated rejection. Clinical trials of clazakizumab for treatment of COVID-19 are underway worldwide.
- Published
- 2020
26. Heart transplantation in the era of the SARS-CoV-2 pandemic: Is it safe and feasible?
- Author
-
Esmailian, Gabriel, Kobashigawa, Jon, Nishihara, Keith, Patel, Jignesh, Czer, Lawrence, Megna, Dominick, Emerson, Dominic, Ramzy, Danny, Trento, Alfredo, Chikwe, Joanna, and Esmailian, Fardad
- Subjects
COVID-19 ,SARS-CoV-2 ,donors and donation ,heart transplantation ,infection and infectious agents ,pandemic ,patient survival ,viral ,Adult ,Aged ,COVID-19 ,California ,Delayed Graft Function ,Feasibility Studies ,Female ,Graft Rejection ,Heart Transplantation ,Hospital Mortality ,Humans ,Infection Control ,Length of Stay ,Male ,Middle Aged ,Outcome Assessment ,Health Care ,Pandemics ,Patient Safety ,Postoperative Complications ,Retrospective Studies ,Survival Analysis - Abstract
As the SARS-CoV-2-pandemic continues to unfold, the number of heart transplants completed in the United States has been declining steadily. The current case series examines the immediate short-term outcomes of seven heart transplant recipients transplanted during the SARS-CoV-2 pandemic. We hope to illustrate that with proper preparation, planning, and testing, heart transplantation can be continued during a pandemic. We assessed 7 patients transplanted from March 4, 2020, to April 15, 2020. The following endpoints were noted: in-hospital survival, in-hospital freedom from rejection, in-hospital nonfatal major cardiac adverse events (NF-MACE), severe primary graft dysfunction, hospital length of stay, and ICU length of stay. There were no expirations throughout the hospital admission. In addition, there were no patients with NF-MACE or treated rejection, and 1 patient developed severe primary graft dysfunction. Average length of stay was 17.2 days with a standard deviation of 5.9 days. ICU length of stay was 7.7 days with a standard deviation of 2.3 days. Despite the decreasing trend in completed heart transplants due to SARS-CoV-2, heart transplantation appears to be feasible in the immediate short term. Further follow-up is needed, however, to assess the impact of SARS-CoV-2 on post-heart transplant outcomes months after transplantation.
- Published
- 2020
27. Discovery of non‐HLA antibodies associated with cardiac allograft rejection and development and validation of a non‐HLA antigen multiplex panel: From bench to bedside
- Author
-
Butler, Carrie L, Hickey, Michelle J, Jiang, Ning, Zheng, Ying, Gjertson, David, Zhang, Qiuheng, Rao, Ping, Fishbein, Gregory A, Cadeiras, Martin, Deng, Mario C, Banchs, Hector L, Torre, Guillermo, DeNofrio, David, Eisen, Howard J, Kobashigawa, Jon, Starling, Randall C, Kfoury, Abdallah, Van Bakel, Adrian, Ewald, Gregory, Balazs, Ivan, Baas, Arnold S, Cruz, Daniel, Ardehali, Reza, Biniwale, Reshma, Kwon, Murray, Ardehali, Abbas, Nsair, Ali, Ray, Bryan, and Reed, Elaine F
- Subjects
Transplantation ,Prevention ,Biotechnology ,Heart Disease ,Clinical Research ,Organ Transplantation ,Cardiovascular ,Inflammatory and immune system ,Allografts ,Antibodies ,Graft Rejection ,HLA Antigens ,Heart Transplantation ,autoantibody ,autoantigen ,clinical research ,practice ,heart transplantation ,cardiology ,histocompatibility ,immunogenetics ,microarray ,protein array ,organ transplantation in general ,rejection ,translational research ,science ,clinical research/practice ,heart transplantation/cardiology ,microarray/protein array ,translational research/science ,Medical and Health Sciences ,Surgery - Abstract
We analyzed humoral immune responses to nonhuman leukocyte antigen (HLA) after cardiac transplantation to identify antibodies associated with allograft rejection. Protein microarray identified 366 non-HLA antibodies (>1.5 fold, P 1R) with an area under the curve of 0.87 (P
- Published
- 2020
28. cBIN1 Score (CS) Identifies Ambulatory HFrEF Patients and Predicts Cardiovascular Events.
- Author
-
Hitzeman, Tara, Xie, Yu, Zadikany, Ronit, Nikolova, Andriana, Baum, Rachel, Caldaruse, Ana-Maria, Agvanian, Sosse, Melmed, Gil, McGovern, Dermot, Geft, Dael, Chang, David, Moriguchi, Jaime, Hage, Antoine, Azarbal, Babak, Czer, Lawrence, Kittleson, Michelle, Patel, Jignesh, Wu, Alan, Kobashigawa, Jon, Hamilton, Michele, Hong, TingTing, and Shaw, Robin
- Subjects
cBIN1 score ,calcium handling ,cardiac muscle remodeling ,heart failure ,ion channels - Abstract
BACKGROUND: Cardiac Bridging Integrator 1 (cBIN1) is a membrane deformation protein that generates calcium microdomains at cardiomyocyte t-tubules, whose transcription is reduced in heart failure, and is released into blood. cBIN1 score (CS), an inverse index of plasma cBIN1, measures cellular myocardial remodeling. In patients with heart failure with preserved ejection fraction (HFpEF), CS diagnoses ambulatory heart failure and prognosticates hospitalization. The performance of CS has not been tested in patients with heart failure with reduced ejection fraction (HFrEF). METHODS AND RESULTS: CS was determined from plasma of patients recruited in a prospective study. Two comparative cohorts consisted of 158 ambulatory HFrEF patients (left ventricular ejection fraction (LVEF) ≤ 40%, 57 ± 10 years, 80% men) and 115 age and sex matched volunteers with no known history of HF. N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations were also analyzed for comparison. CS follows a normal distribution with a median of 0 in the controls, which increases to a median of 1.9 (p < 0.0001) in HFrEF patients. CS correlates with clinically assessed New York Heart Association Class (p = 0.007). During 1-year follow-up, a high CS (≥ 1.9) in patients predicts increased cardiovascular events (43% vs. 26%, p = 0.01, hazard ratio 1.9). Compared to a model with demographics, clinical risk factors, and NT-proBNP, adding CS to the model improved the overall continuous net reclassification improvement (NRI 0.64; 95% CI 0.18-1.10; p = 0.006). Although performance for diagnosis and prognosis was similar to CS, NT-proBNP did not prognosticate between patients whose NT-proBNP values were > 400 pg/ml. CONCLUSION: CS, which is mechanistically distinct from NT-proBNP, successfully differentiates myocardial health between patients with HFrEF and matched controls. A high CS reflects advanced NYHA stage, pathologic cardiac muscle remodeling, and predicts 1-year risk of cardiovascular events in ambulatory HFrEF patients. CS is a marker of myocardial remodeling in HFrEF patients, independent of volume status.
- Published
- 2020
29. Heart transplantation using donation after circulatory death in the United States
- Author
-
Chen, Qiudong, Emerson, Dominic, Megna, Dominick, Osho, Asishana, Roach, Amy, Chan, Joshua, Rowe, Georgina, Gill, George, Esmailian, Fardad, Chikwe, Joanna, Egorova, Natalia, Kirklin, James K., Kobashigawa, Jon, and Catarino, Pedro
- Published
- 2023
- Full Text
- View/download PDF
30. Addressing sex-based disparities in solid organ transplantation in the United States – a conference report
- Author
-
Sawinski, Deirdre, Lai, Jennifer C., Pinney, Sean, Gray, Alice L., Jackson, Annette M., Stewart, Darren, Levine, Deborah Jo, Locke, Jayme E., Pomposelli, James J., Hartwig, Matthew G., Hall, Shelley A., Dadhania, Darshana M., Cogswell, Rebecca, Perez, Richard V., Schold, Jesse D., Turgeon, Nicole A., Kobashigawa, Jon, Kukreja, Jasleen, Magee, John C., Friedewald, John, Gill, John S., Loor, Gabriel, Heimbach, Julie K., Verna, Elizabeth C., Walsh, Mary Norine, Terrault, Norah, Testa, Guiliano, Diamond, Joshua M., Reese, Peter P., Brown, Kimberly, Orloff, Susan, Farr, Maryjane A., Olthoff, Kim M., Siegler, Mark, Ascher, Nancy, Feng, Sandy, Kaplan, Bruce, and Pomfret, Elizabeth
- Published
- 2023
- Full Text
- View/download PDF
31. Abstract 17038: Mineralocorticoid Antagonist Use for Transthyretin Amyloid Cardiomyopathy and Associated Outcomes
- Author
-
Stern, Lily K, Kim, Seong Kyu, Singer-Englar, Tahli, Kobashigawa, Jon A, Kittleson, Michelle M, and Patel, Jignesh K
- Published
- 2023
- Full Text
- View/download PDF
32. Heart transplantation for COVID-19 myopathy in the United States
- Author
-
Gill, George, Roach, Amy, Rowe, Georgina, Emerson, Dominic, Kobashigawa, Jon, Lobo, Errol P., Esmailian, Fardad, Bowdish, Michael E., and Chikwe, Joanna
- Published
- 2023
- Full Text
- View/download PDF
33. Intermediate-term outcomes of complement inhibition for prevention of antibody-mediated rejection in immunologically high-risk heart allograft recipients
- Author
-
Coutance, Guillaume, Kobashigawa, Jon A., Kransdorf, Evan, Loupy, Alexandre, Desiré, Eva, Kittleson, Michelle, and Patel, Jignesh K.
- Published
- 2023
- Full Text
- View/download PDF
34. Donor heart selection: Evidence-based guidelines for providers
- Author
-
Copeland, Hannah, Knezevic, Ivan, Baran, David A., Rao, Vivek, Pham, Michael, Gustafsson, Finn, Pinney, Sean, Lima, Brian, Masetti, Marco, Ciarka, Agnieszka, Rajagopalan, Navin, Torres, Adriana, Hsich, Eileen, Patel, Jignesh K., Goldraich, Livia Adams, Colvin, Monica, Segovia, Javier, Ross, Heather, Ginwalla, Mahazarin, Sharif-Kashani, Babak, Farr, MaryJane A., Potena, Luciano, Kobashigawa, Jon, Crespo-Leiro, Maria G., Altman, Natasha, Wagner, Florian, Cook, Jennifer, Stosor, Valentina, Grossi, Paolo A., Khush, Kiran, Yagdi, Tahir, Restaino, Susan, Tsui, Steven, Absi, Daniel, Sokos, George, Zuckermann, Andreas, Wayda, Brian, Felius, Joost, and Hall, Shelley A.
- Published
- 2023
- Full Text
- View/download PDF
35. Three year post heart transplant outcomes of desensitized durable mechanical circulatory support patients
- Author
-
Youn, Jong-Chan, Kim, Darae, Jung, Mi-Hyang, Kim, Jin-Jin, Kim, In-Cheol, Lee, Hye Sun, Choi, Jin-Oh, Jeon, Eun-Seok, Nishihara, Keith, Seguchi, Osamu, Kransdorf, Evan P., Chang, David H., Kittleson, Michelle M., Patel, Jignesh K., Cole, Robert M., Moriguchi, Jaime D., Ramzy, Danny, Esmailian, Fardad, and Kobashigawa, Jon A.
- Published
- 2023
- Full Text
- View/download PDF
36. Clinical recommendations for posttransplant assessment of anti–HLA (Human Leukocyte Antigen) donor-specific antibodies: A Sensitization in Transplantation: Assessment of Risk consensus document
- Author
-
Kobashigawa, Jon A., Chandraker, Anil, Chang, Patricia P., Colvin, Monica M., Hachem, Ramsey R., Snyder, Laurie D., Sweet, Stuart C., Levine, Deborah J., Knechtle, Stuart J., O’Leary, Jacqueline G., Levitsky, Joshua, Lefaucheur, Carmen, Louis, Kevin, Morris, Anna B., Taupin, Jean-Luc, Nickerson, Peter, Tambur, Anat R., Gebel, Howard M., and Reed, Elaine F.
- Published
- 2023
- Full Text
- View/download PDF
37. Accelerated Cardiac Diffusion Tensor Imaging Using Joint Low-Rank and Sparsity Constraints
- Author
-
Ma, Sen, Nguyen, Christopher T., Christodoulou, Anthony G., Luthringer, Daniel, Kobashigawa, Jon, Lee, Sang-Eun, Chang, Hyuk-Jae, and Li, Debiao
- Subjects
Electrical Engineering and Systems Science - Signal Processing - Abstract
Objective: The purpose of this manuscript is to accelerate cardiac diffusion tensor imaging (CDTI) by integrating low-rankness and compressed sensing. Methods: Diffusion-weighted images exhibit both transform sparsity and low-rankness. These properties can jointly be exploited to accelerate CDTI, especially when a phase map is applied to correct for the phase inconsistency across diffusion directions, thereby enhancing low-rankness. The proposed method is evaluated both ex vivo and in vivo, and is compared to methods using either a low-rank or sparsity constraint alone. Results: Compared to using a low-rank or sparsity constraint alone, the proposed method preserves more accurate helix angle features, the transmural continuum across the myocardium wall, and mean diffusivity at higher acceleration, while yielding significantly lower bias and higher intraclass correlation coefficient. Conclusion: Low-rankness and compressed sensing together facilitate acceleration for both ex vivo and in vivo CDTI, improving reconstruction accuracy compared to employing either constraint alone. Significance: Compared to previous methods for accelerating CDTI, the proposed method has the potential to reach higher acceleration while preserving myofiber architecture features which may allow more spatial coverage, higher spatial resolution and shorter temporal footprint in the future., Comment: 11 pages, 16 figures, published on IEEE Transactions on Biomedical Engineering
- Published
- 2018
- Full Text
- View/download PDF
38. Report from the American Society of Transplantation on frailty in solid organ transplantation.
- Author
-
Kobashigawa, Jon, Dadhania, Darshana, Bhorade, Sangeeta, Adey, Deborah, Berger, Joseph, Bhat, Geetha, Budev, Marie, Duarte-Rojo, Andres, Dunn, Michael, Hall, Shelley, Harhay, Meera N, Johansen, Kirsten L, Joseph, Susan, Kennedy, Cassie C, Kransdorf, Evan, Lentine, Krista L, Lynch, Raymond J, McAdams-DeMarco, Mara, Nagai, Shunji, Olymbios, Michael, Patel, Jignesh, Pinney, Sean, Schaenman, Joanna, Segev, Dorry L, Shah, Palak, Singer, Lianne G, Singer, Jonathan P, Sonnenday, Christopher, Tandon, Puneeta, Tapper, Elliot, Tullius, Stefan G, Wilson, Michael, Zamora, Martin, and Lai, Jennifer C
- Subjects
Humans ,Organ Transplantation ,Health Care Rationing ,Societies ,Medical ,United States ,Frailty ,clinical research/practice ,heart disease ,immune regulation ,kidney disease ,kidney transplantation/nephrology ,liver disease ,liver transplantation/hepatology ,lung disease ,lung transplantation/pulmonology ,Transplantation ,Kidney Disease ,clinical research ,practice ,kidney transplantation ,nephrology ,liver transplantation ,hepatology ,lung transplantation ,pulmonology ,Medical and Health Sciences ,Surgery - Abstract
A consensus conference on frailty in kidney, liver, heart, and lung transplantation sponsored by the American Society of Transplantation (AST) and endorsed by the American Society of Nephrology (ASN), the American Society of Transplant Surgeons (ASTS), and the Canadian Society of Transplantation (CST) took place on February 11, 2018 in Phoenix, Arizona. Input from the transplant community through scheduled conference calls enabled wide discussion of current concepts in frailty, exploration of best practices for frailty risk assessment of transplant candidates and for management after transplant, and development of ideas for future research. A current understanding of frailty was compiled by each of the solid organ groups and is presented in this paper. Frailty is a common entity in patients with end-stage organ disease who are awaiting organ transplantation, and affects mortality on the waitlist and in the posttransplant period. The optimal methods by which frailty should be measured in each organ group are yet to be determined, but studies are underway. Interventions to reverse frailty vary among organ groups and appear promising. This conference achieved its intent to highlight the importance of frailty in organ transplantation and to plant the seeds for further discussion and research in this field.
- Published
- 2019
39. Combined Heart and Kidney Transplantation: Clinical Experience in 100 Consecutive Patients.
- Author
-
Awad, Morcos, Czer, Lawrence, Emerson, Dominic, Jordan, Stanley, De Robertis, Michele, Mirocha, James, Kransdorf, Evan, Chang, David, Patel, Jignesh, Kittleson, Michelle, Ramzy, Danny, Chung, Joshua, Cohen, J, Esmailian, Fardad, Trento, Alfredo, and Kobashigawa, Jon
- Subjects
heart failure ,heart transplantation ,hemodialysis ,kidney transplantation ,mortality ,renal disease ,Aged ,Female ,Follow-Up Studies ,Forecasting ,Graft Rejection ,Heart Failure ,Heart Transplantation ,Humans ,Incidence ,Kidney Transplantation ,Male ,Middle Aged ,Prognosis ,Renal Dialysis ,Renal Insufficiency ,Retrospective Studies ,Risk Factors ,Survival Rate ,United States ,Waiting Lists - Abstract
Background Combined heart and kidney transplantation ( HKT x) is performed in patients with severe heart failure and advanced renal insufficiency. We analyzed the long-term survival after HKT x, the influence of age and dialysis status, the rates of cardiac rejection, and the influence of sensitization. Methods and Results From June 1992 to December 2016, we performed 100 HKT x procedures. We compared older (≥60 years, n=53) with younger (50%, and compared these survival rates with those from the United Network for Organ Sharing database. There was no difference in 15-year survival between the 2 age groups (35±12.4% and 49±17.3%, ≥60 versus 0 or antibody-mediated rejection >0) was 92±2.8% and 84±3.8%, acute cellular rejection (≥2R/3A) 98±1.5% and 94±2.5%, and antibody-mediated rejection (≥1) 96±2.1% and 93±2.6% at 30 days and 1 year after HKT x. There was no difference in the 5-year survival among recipients by sensitization status with panel-reactive antibody levels 50% (82±5.9%, 83±10.8%, and 92±8.0%; P=0.55). There was no difference in 15-year survival after HKT x between the United Network for Organ Sharing database and our center (38±3.2% and 40±10.1%, respectively; P=0.45). Conclusions HKT x is safe to perform in patients 60 years and older or younger than 60 years and with or without dialysis dependence, with excellent outcomes. The degree of panel-reactive antibody sensitization did not appear to affect survival after HKT x.
- Published
- 2019
40. Heart Transplantation With Older Donors: Should There Be an Age Cutoff?
- Author
-
Chen, Qiudong, Kobashigawa, Jon, Emerson, Dominic, Singer-Englar, Tahli, Megna, Dominick, Ramzy, Danny, Catarino, Pedro, Trento, Alfredo, Chikwe, Joanna, Kittleson, Michelle, and Esmailian, Fardad
- Published
- 2022
- Full Text
- View/download PDF
41. Long-term preservation of functional capacity and quality of life in advanced heart failure patients with bridge to transplant therapy: A report from Japanese nationwide multicenter registry
- Author
-
Sato, Takuma, Kobayashi, Yuta, Nagai, Toshiyuki, Nakatani, Takeshi, Kobashigawa, Jon, Saiki, Yoshikatsu, Ono, Minoru, Wakasa, Satoru, and Anzai, Toshihisa
- Published
- 2022
- Full Text
- View/download PDF
42. Alterations in the kallikrein-kinin system predict death after heart transplant
- Author
-
Giangreco, Nicholas P., Lebreton, Guillaume, Restaino, Susan, Farr, Maryjane, Zorn, Emmanuel, Colombo, Paolo C., Patel, Jignesh, Soni, Rajesh Kumar, Leprince, Pascal, Kobashigawa, Jon, Tatonetti, Nicholas P., and Fine, Barry M.
- Published
- 2022
- Full Text
- View/download PDF
43. Transplant centers that assess frailty as part of clinical practice have better outcomes
- Author
-
Chen, Xiaomeng, Liu, Yi, Thompson, Valerie, Chu, Nadia M., King, Elizabeth A., Walston, Jeremy D., Kobashigawa, Jon A., Dadhania, Darshana M., Segev, Dorry L., and McAdams-DeMarco, Mara A.
- Published
- 2022
- Full Text
- View/download PDF
44. Cardiac microstructural alterations in immune-inflammatory myocardial disease: a retrospective case-control study
- Author
-
Kwan, Alan C., Salto, Gerran, Nguyen, Trevor-Trung, Kim, Elizabeth H., Luong, Eric, Hiremath, Pranoti, Ouyang, David, Ebinger, Joseph E., Li, Debiao, Berman, Daniel S., Kittleson, Michelle M., Kobashigawa, Jon A., Patel, Jignesh K., and Cheng, Susan
- Published
- 2022
- Full Text
- View/download PDF
45. Heterogeneity of liver fibrosis in patients with congestive hepatopathy: A biopsy and explant comparison series
- Author
-
Rushakoff, Joshua A., Kransdorf, Evan P., Patel, Jignesh K., Kobashigawa, Jon A., Sundaram, Vinay, and Guindi, Maha
- Published
- 2022
- Full Text
- View/download PDF
46. Perceived control and health-related quality of life in heart transplant recipients.
- Author
-
Doering, Lynn V, Chen, Belinda, Deng, Mario, Mancini, Donna, Kobashigawa, Jon, and Hickey, Kathleen
- Subjects
Humans ,Heart Transplantation ,Cross-Sectional Studies ,Adaptation ,Psychological ,Anxiety Disorders ,Quality of Life ,Adolescent ,Adult ,Aged ,Middle Aged ,Female ,Male ,Transplant Recipients ,Perceived control ,anxiety ,depression ,health-related quality of life ,heart transplantation ,Cardiovascular Medicine And Haematology ,Nursing ,Public Health And Health Services ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services - Abstract
BACKGROUND:Perceived control has been associated with improved mental health and health-related quality of life (HRQOL) in cardiac populations. However, this concept has not been well-studied in heart transplant groups. AIMS:We examine the relationship of perceived control to symptoms of anxiety and depression and HRQOL after transplant. We also examine the extent to which anxiety and depressive symptoms mediate the relationship between perceived control and HRQOL. METHODS:Our cross-sectional analysis included 113 adult heart transplant patients from the NEW HEART study. High versus low perceived control groups were determined by median split for chi-square and t-test analyses. Hierarchical multiple linear regression models were used to examine the influence of perceived control on symptoms of depression and anxiety and HRQOL. Mediation analyses included Baron and Kenny's four-step regression approach and Preacher and Hayes' bootstrapping technique to test the indirect effect of perceived control on HRQOL. RESULTS:Heart transplant patients who reported lower perceived control were more likely to be female ( p=0.003), and had significantly more depressive symptoms ( p
- Published
- 2018
47. Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis.
- Author
-
Bouquegneau, Antoine, Loheac, Charlotte, Aubert, Olivier, Bouatou, Yassine, Viglietti, Denis, Empana, Jean-Philippe, Ulloa, Camilo, Murad, Mohammad Hassan, Legendre, Christophe, Glotz, Denis, Jackson, Annette M, Zeevi, Adriana, Schaub, Stephan, Taupin, Jean-Luc, Reed, Elaine F, Friedewald, John J, Tyan, Dolly B, Süsal, Caner, Shapiro, Ron, Woodle, E Steve, Hidalgo, Luis G, O'Leary, Jacqueline, Montgomery, Robert A, Kobashigawa, Jon, Jouven, Xavier, Jabre, Patricia, Lefaucheur, Carmen, and Loupy, Alexandre
- Subjects
Humans ,Antibodies ,HLA Antigens ,Complement Activation ,Transplantation Immunology ,Graft Rejection ,Graft Survival ,General & Internal Medicine ,Medical and Health Sciences - Abstract
BACKGROUND:Anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) are recognized as a major barrier to patients' access to organ transplantation and the major cause of graft failure. The capacity of circulating anti-HLA DSAs to activate complement has been suggested as a potential biomarker for optimizing graft allocation and improving the rate of successful transplantations. METHODS AND FINDINGS:To address the clinical relevance of complement-activating anti-HLA DSAs across all solid organ transplant patients, we performed a meta-analysis of their association with transplant outcome through a systematic review, from inception to January 31, 2018. The primary outcome was allograft loss, and the secondary outcome was allograft rejection. A comprehensive search strategy was conducted through several databases (Medline, Embase, Cochrane, and Scopus). A total of 5,861 eligible citations were identified. A total of 37 studies were included in the meta-analysis. Studies reported on 7,936 patients, including kidney (n = 5,991), liver (n = 1,459), heart (n = 370), and lung recipients (n = 116). Solid organ transplant recipients with circulating complement-activating anti-HLA DSAs experienced an increased risk of allograft loss (pooled HR 3.09; 95% CI 2.55-3.74, P = 0.001; I2 = 29.3%), and allograft rejection (pooled HR 3.75; 95% CI: 2.05-6.87, P = 0.001; I2 = 69.8%) compared to patients without complement-activating anti-HLA DSAs. The association between circulating complement-activating anti-HLA DSAs and allograft failure was consistent across all subgroups and sensitivity analyses. Limitations of the study are the observational and retrospective design of almost all included studies, the higher proportion of kidney recipients compared to other solid organ transplant recipients, and the inclusion of fewer studies investigating allograft rejection. CONCLUSIONS:In this study, we found that circulating complement-activating anti-HLA DSAs had a significant deleterious impact on solid organ transplant survival and risk of rejection. The detection of complement-activating anti-HLA DSAs may add value at an individual patient level for noninvasive biomarker-guided risk stratification. TRIAL REGISTRATION:National Clinical Trial protocol ID: NCT03438058.
- Published
- 2018
48. Diagnostic Accuracy of Cardiovascular Magnetic Resonance for Cardiac Transplant Rejection: A Meta-Analysis
- Author
-
Han, Donghee, Miller, Robert J.H., Otaki, Yuka, Gransar, Heidi, Kransdorf, Evan, Hamilton, Michelle, Kittelson, Michele, Patel, Jignesh, Kobashigawa, Jon A., Thomson, Louise, Berman, Daniel, and Tamarappoo, Balaji
- Published
- 2021
- Full Text
- View/download PDF
49. Immunosuppression in Cardiac Transplantation
- Author
-
Xie, Yu, Lor, Kevin W., Kobashigawa, Jon A., and Raja, Shahzad G., editor
- Published
- 2020
- Full Text
- View/download PDF
50. Contemporary Left Ventricular Assist Device Outcomes in an Aging Population: An STS INTERMACS Analysis
- Author
-
Emerson, Dominic, Chikwe, Joanna, Catarino, Pedro, Hassanein, Mohamed, Deng, Luqin, Cantor, Ryan S., Roach, Amy, Cole, Robert, Esmailian, Fardad, Kobashigawa, Jon, Moriguchi, Jaime, and Kirklin, James K.
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.