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10 results on '"Ko LA"'

1. Federated Deep Q-Learning and 5G load balancing

Author

Lin, Hsin, Su, Yi-Kang, Chen, Hong-Qi, and Ko, La-Fei

Subjects
Computer Science - Networking and Internet Architecture, Computer Science - Artificial Intelligence, Computer Science - Machine Learning, Computer Science - Multiagent Systems
Abstract

Despite advances in cellular network technology, base station (BS) load balancing remains a persistent problem. Although centralized resource allocation methods can address the load balancing problem, it still remains an NP-hard problem. In this research, we study how federated deep Q learning can be used to inform each user equipment (UE) of the each BS's load conditions. Federated deep Q learning's load balancing enables intelligent UEs to independently select the best BS while also limiting the amount of private information exposed to the network. In this study, we propose and analyze a federated deep Q learning load balancing system, which is implemented using the Open-RAN xAPP framework and the near-Real Time Radio Interface Controller (near-RT RIC). Our simulation results indicate that compared to the maximum Signal-To-Noise-Ratio (MAX-SINR) method currently used by UEs, our proposed deep Q learning model can consistently provide better High average UE quality of service, Comment: 5 pages, in Chinese language. 8 figures. Presented at 2022 Taiwan telecommunications annual symposium

Published
2024

5. Yorùbá Diaspora

Author

Abímbó¸lá, Kó¸lá, Ember, Melvin, editor, Ember, Carol R., editor, and Skoggard, Ian, editor

Published
2005
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6. Nanoporous gold electrodes as matrices for enzyme immobilization for application in biosensors and biofuel cells

Author

Salaj-Ko??la, Urszula and Magner, Edmond

Subjects
nanoporous gold electrodes, biofuel cells
Abstract

peer-reviewed Robust nanoporous gold electrodes were fabricated by sputtering a gold-silver alloy onto a glass support and subsequent dealloying of the silver component. Alloys were prepared with either a non-uniform or uniform distribution of silver alloy which showed clear differences in morphology on characterization with scanning electron microscopy. The surface area of these electrodes was up to 28 times that of the geometric surface area. The surface area accessible to modification by redox proteins was determined using cyt c as a model system. Covalent immobilization of cyt c at SAMs modified planar and nanoporous gold electrodes resulted in ca. 9 and 11 times higher surface coverages at uniform and non-uniform nanoporous gold, respectively, than at planar gold electrodes. Well defined mediatorless bioelecytrocatalytic reduction of oxygen was obtained on nanoporous gold electrodes prepared using a vacuum method and subsequently modified with Myrthecium verrucaria bilirubin oxidase (MvBOD). Diffusion limited faradaic response, with current densities of 0.8 mA/cm2, was observed when the enzyme modified electrode was stabilized with a layer the P017-epoxy polymer. The enzyme, Trametes hirsuta laccase (ThLc) also displayes direct electron transfer at unmodified nanoporous gold electrodes. The observed current densities of ca. 0.03 mA/cm2 were 10 times higher than the current densities at the ThLc modified electrode made by drop-casting and are in contrast to the absence of a response at unmodified polycrystalline gold electrodes. Nanoporous and planar gold electrodes modified with Aspergillus niger glucose oxidase (GOx) and Corynascus thermophilus cellobiose dehydrogenase (CtCDH) together with Os redox mediators and PEGDGE as a cross-linking agent resulted in glucose and lactose detecting biosensors. The sensors had (Imax,app, KM,app, sensitivity), limits of detection (LOD). GOx and CtCDH modified electrodes were utilized as anodes with MvBOD and Melanocarpus albomyces Lc (rMaLc) modified cathodes in biofuel cells. A maximal power density of 41 ??A/cm2 for the CtCDH/MvBOD biofuel cell in 5 mM lactose and O2 saturated buffer was obtained. The power densities of the biofuel cells were also evaluated in artificial plasma, where decreased values were observed.

Published
2012

8. Increasing the interpretive flexibility of information systems through embedded application systems

Author

Ka¨ko¨la¨, Timo K.

Abstract

The conceptual structure of most computer-based information systems reflects a dualism of technology. During the development phase, part of the work-domain related knowledge is formalized and encoded in the software, making it difficult for users to reflect upon and use this knowledge. This dualism deters the interpretive flexibility of information systems. In this paper, I propose the Embedded Systems Approach, a redesign of the conceptual structure of software systems that lets users acknowledge the constructed, dual nature of information systems. In this approach, applications are embedded in extended support systems that make the organization of work and the coordinating role of information systems explicit. It also helps users handle breakdowns. The resulting systems are called Embedded Application Systems. I describe the XTEND2 prototype to illustrate the approach and to inspire commercial implementations.

Published
1995
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9. Disease-Linked Regulatory DNA Variants and Homeostatic Transcription Factors in Epidermis.

Author

Porter DF, Meyers RM, Miao W, Reynolds DL, Hong AW, Yang X, Mondal S, Siprashvili Z, Srinivasan S, Ducoli L, Meyers JM, Nguyen DT, Ko LA, Kellman L, Elfaki I, Guo M, Winge MC, Lopez-Pajares V, Porter IE, Tao S, and Khavari PA

Abstract

Identifying noncoding single nucleotide variants ( SNVs ) in regulatory DNA linked to polygenic disease risk, the transcription factors ( TFs ) they bind, and the target genes they dysregulate is a goal in polygenic disease research. Massively parallel reporter gene analysis ( MPRA ) of 3,451 SNVs linked to risk for polygenic skin diseases characterized by disrupted epidermal homeostasis identified 355 differentially active SNVs ( daSNVs ). daSNV target gene analysis, combined with daSNV editing, underscored dysregulated epidermal differentiation as a pathomechanism shared across common polygenic skin diseases. CRISPR knockout screens of 1772 human TFs revealed 108 TFs essential for epidermal progenitor differentiation, uncovering novel roles for ZNF217, CXXC1, FOXJ2, IRX2 and NRF1. Population sampling CUT&RUN of 27 homeostatic TFs identified allele-specific DNA binding ( ASB ) differences at daSNVs enriched near epidermal homeostasis and monogenic skin disease genes, with notable representation of SP/KLF and AP-1/2 TFs. This resource implicates dysregulated differentiation in risk for diverse polygenic skin diseases.

Published
2024
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10. Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation.

Author

Miao W, Porter DF, Lopez-Pajares V, Siprashvili Z, Meyers RM, Bai Y, Nguyen DT, Ko LA, Zarnegar BJ, Ferguson ID, Mills MM, Jilly-Rehak CE, Wu CG, Yang YY, Meyers JM, Hong AW, Reynolds DL, Ramanathan M, Tao S, Jiang S, Flynn RA, Wang Y, Nolan GP, and Khavari PA

Subjects
Cell Nucleolus metabolism, Cell Nucleus metabolism, RNA, Messenger genetics, RNA, Messenger metabolism, Humans, DEAD-box RNA Helicases metabolism, Glucose metabolism, Keratinocytes cytology, Keratinocytes metabolism
Abstract

Glucose is a universal bioenergy source; however, its role in controlling protein interactions is unappreciated, as are its actions during differentiation-associated intracellular glucose elevation. Azido-glucose click chemistry identified glucose binding to a variety of RNA binding proteins (RBPs), including the DDX21 RNA helicase, which was found to be essential for epidermal differentiation. Glucose bound the ATP-binding domain of DDX21, altering protein conformation, inhibiting helicase activity, and dissociating DDX21 dimers. Glucose elevation during differentiation was associated with DDX21 re-localization from the nucleolus to the nucleoplasm where DDX21 assembled into larger protein complexes containing RNA splicing factors. DDX21 localized to specific SCUGSDGC motif in mRNA introns in a glucose-dependent manner and promoted the splicing of key pro-differentiation genes, including GRHL3, KLF4, OVOL1, and RBPJ. These findings uncover a biochemical mechanism of action for glucose in modulating the dimerization and function of an RNA helicase essential for tissue differentiation., Competing Interests: Declaration of interests The authors declare no competing interests., (Published by Elsevier Inc.)

Published
2023
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