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1,436 results on '"Knutsson, Anders"'

1. Long working hours and change in body weight: analysis of individual-participant data from 19 cohort studies

Author

Virtanen, Marianna, Jokela, Markus, Lallukka, Tea, Magnusson Hanson, Linda, Pentti, Jaana, Nyberg, Solja T., Alfredsson, Lars, Batty, G. David, Casini, Annalisa, Clays, Els, DeBacquer, Dirk, Ervasti, Jenni, Fransson, Eleonor, Halonen, Jaana I., Head, Jenny, Kittel, France, Knutsson, Anders, Leineweber, Constanze, Nordin, Maria, Oksanen, Tuula, Pietiläinen, Olli, Rahkonen, Ossi, Salo, Paula, Singh-Manoux, Archana, Stenholm, Sari, Suominen, Sakari B., Theorell, Töres, Vahtera, Jussi, Westerholm, Peter, Westerlund, Hugo, and Kivimäki, Mika

Published
2020
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2. Obesity and loss of disease-free years owing to major non-communicable diseases: a multicohort study

Author

Nyberg, Solja T, Batty, G David, Pentti, Jaana, Virtanen, Marianna, Alfredsson, Lars, Fransson, Eleonor I, Goldberg, Marcel, Heikkilä, Katriina, Jokela, Markus, Knutsson, Anders, Koskenvuo, Markku, Lallukka, Tea, Leineweber, Constanze, Lindbohm, Joni V, Madsen, Ida E H, Magnusson Hanson, Linda L, Nordin, Maria, Oksanen, Tuula, Pietiläinen, Olli, Rahkonen, Ossi, Rugulies, Reiner, Shipley, Martin J, Stenholm, Sari, Suominen, Sakari, Theorell, Töres, Vahtera, Jussi, Westerholm, Peter J M, Westerlund, Hugo, Zins, Marie, Hamer, Mark, Singh-Manoux, Archana, Bell, Joshua A, Ferrie, Jane E, and Kivimäki, Mika

Published
2018
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3. Long working hours and depressive symptoms : systematic review and meta-analysis of published studies and unpublished individual participant data

Author

Virtanen, Marianna, Jokela, Markus, Madsen, Ida EH, Hanson, Linda L Magnusson, Lallukka, Tea, Nyberg, Solja T, Alfredsson, Lars, Batty, G David, Bjorner, Jakob B, Borritz, Marianne, Burr, Hermann, Dragano, Nico, Erbel, Raimund, Ferrie, Jane E, Heikkilä, Katriina, Knutsson, Anders, Koskenvuo, Markku, Lahelma, Eero, Nielsen, Martin L, Oksanen, Tuula, Pejtersen, Jan H, Pentti, Jaana, Rahkonen, Ossi, Rugulies, Reiner, Salo, Paula, Schupp, Jürgen, Shipley, Martin J, Siegrist, Johannes, Singh-Manoux, Archana, Suominen, Sakari B, Theorell, Töres, Vahtera, Jussi, Wagner, Gert G, Wang, Jian Li, Yiengprugsawan, Vasoontara, Westerlund, Hugo, and Kivimäki, Mika

Published
2018

5. Work stress and risk of death in men and women with and without cardiometabolic disease: a multicohort study

Author

Kivimäki, Mika, Pentti, Jaana, Ferrie, Jane E, Batty, G David, Nyberg, Solja T, Jokela, Markus, Virtanen, Marianna, Alfredsson, Lars, Dragano, Nico, Fransson, Eleonor I, Goldberg, Marcel, Knutsson, Anders, Koskenvuo, Markku, Koskinen, Aki, Kouvonen, Anne, Luukkonen, Ritva, Oksanen, Tuula, Rugulies, Reiner, Siegrist, Johannes, Singh-Manoux, Archana, Suominen, Sakari, Theorell, Töres, Väänänen, Ari, Vahtera, Jussi, Westerholm, Peter J M, Westerlund, Hugo, Zins, Marie, Strandberg, Timo, Steptoe, Andrew, and Deanfield, John

Published
2018
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6. Body mass index and risk of dementia: Analysis of individual-level data from 1.3 million individuals

Author

Kivimäki, Mika, Luukkonen, Ritva, Batty, G. David, Ferrie, Jane E., Pentti, Jaana, Nyberg, Solja T., Shipley, Martin J., Alfredsson, Lars, Fransson, Eleonor I., Goldberg, Marcel, Knutsson, Anders, Koskenvuo, Markku, Kuosma, Eeva, Nordin, Maria, Suominen, Sakari B., Theorell, Töres, Vuoksimaa, Eero, Westerholm, Peter, Westerlund, Hugo, Zins, Marie, Kivipelto, Miia, Vahtera, Jussi, Kaprio, Jaakko, Singh-Manoux, Archana, and Jokela, Markus

Published
2018
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7. Effort–Reward Imbalance at Work and Incident Coronary Heart Disease : A Multicohort Study of 90,164 Individuals

Author

IPD-Work consortium, Dragano, Nico, Siegrist, Johannes, Nyberg, Solja T., Lunau, Thorsten, Fransson, Eleonor I., Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Erbel, Raimund, Fahlén, Göran, Goldberg, Marcel, Hamer, Mark, Heikkilä, Katriina, Jöckel, Karl-Heinz, Knutsson, Anders, Madsen, Ida E. H., Nielsen, Martin L., Nordin, Maria, Oksanen, Tuula, Pejtersen, Jan H., Pentti, Jaana, Rugulies, Reiner, Salo, Paula, Schupp, Jürgen, Singh-Manoux, Archana, Steptoe, Andrew, Theorell, Töres, Vahtera, Jussi, Westerholm, Peter J. M., Westerlund, Hugo, Virtanen, Marianna, Zins, Marie, Batty, G.David, and Kivimäki, Mika

Published
2017

9. Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe

Author

Kivimäki, Mika, Kuosma, Eeva, Ferrie, Jane E, Luukkonen, Ritva, Nyberg, Solja T, Alfredsson, Lars, Batty, G David, Brunner, Eric J, Fransson, Eleonor, Goldberg, Marcel, Knutsson, Anders, Koskenvuo, Markku, Nordin, Maria, Oksanen, Tuula, Pentti, Jaana, Rugulies, Reiner, Shipley, Martin J, Singh-Manoux, Archana, Steptoe, Andrew, Suominen, Sakari B, Theorell, Töres, Vahtera, Jussi, Virtanen, Marianna, Westerholm, Peter, Westerlund, Hugo, Zins, Marie, Hamer, Mark, Bell, Joshua A, Tabak, Adam G, and Jokela, Markus

Published
2017
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10. Long working hours and risk of coronary heart disease and stroke: a systematic review and meta-analysis of published and unpublished data for 603 838 individuals

Author

Kivimäki, Mika, Jokela, Markus, Nyberg, Solja T, Singh-Manoux, Archana, Fransson, Eleonor I, Alfredsson, Lars, Bjorner, Jakob B, Borritz, Marianne, Burr, Hermann, Casini, Annalisa, Clays, Els, De Bacquer, Dirk, Dragano, Nico, Erbel, Raimund, Geuskens, Goedele A, Hamer, Mark, Hooftman, Wendela E, Houtman, Irene L, Jöckel, Karl-Heinz, Kittel, France, Knutsson, Anders, Koskenvuo, Markku, Lunau, Thorsten, Madsen, Ida E H, Nielsen, Martin L, Nordin, Maria, Oksanen, Tuula, Pejtersen, Jan H, Pentti, Jaana, Rugulies, Reiner, Salo, Paula, Shipley, Martin J, Siegrist, Johannes, Steptoe, Andrew, Suominen, Sakari B, Theorell, Töres, Vahtera, Jussi, Westerholm, Peter J M, Westerlund, Hugo, O'Reilly, Dermot, Kumari, Meena, Batty, G David, Ferrie, Jane E, and Virtanen, Marianna

Published
2015
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11. Long working hours, socioeconomic status, and the risk of incident type 2 diabetes: a meta-analysis of published and unpublished data from 222 120 individuals

Author

Kivimäki, Mika, Virtanen, Marianna, Kawachi, Ichiro, Nyberg, Solja T, Alfredsson, Lars, Batty, G David, Bjorner, Jakob B, Borritz, Marianne, Brunner, Eric J, Burr, Hermann, Dragano, Nico, Ferrie, Jane E, Fransson, Eleonor I, Hamer, Mark, Heikkilä, Katriina, Knutsson, Anders, Koskenvuo, Markku, Madsen, Ida E H, Nielsen, Martin L, Nordin, Maria, Oksanen, Tuula, Pejtersen, Jan H, Pentti, Jaana, Rugulies, Reiner, Salo, Paula, Siegrist, Johannes, Steptoe, Andrew, Suominen, Sakari, Theorell, Töres, Vahtera, Jussi, Westerholm, Peter J M, Westerlund, Hugo, Singh-Manoux, Archana, and Jokela, Markus

Published
2015
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13. Long working hours and alcohol use : systematic review and meta-analysis of published studies and unpublished individual participant data

Author

Virtanen, Marianna, Jokela, Markus, Nyberg, Solja T, Madsen, Ida E H, Lallukka, Tea, Ahola, Kirsi, Alfredsson, Lars, Batty, G David, Bjorner, Jakob B, Borritz, Marianne, Burr, Hermann, Casini, Annalisa, Clays, Els, De Bacquer, Dirk, Dragano, Nico, Erbel, Raimund, Ferrie, Jane E, Fransson, Eleonor I, Hamer, Mark, Heikkilä, Katriina, Jöckel, Karl-Heinz, Kittel, France, Knutsson, Anders, Koskenvuo, Markku, Ladwig, Karl-Heinz, Lunau, Thorsten, Nielsen, Martin L, Nordin, Maria, Oksanen, Tuula, Pejtersen, Jan H, Pentti, Jaana, Rugulies, Reiner, Salo, Paula, Schupp, Jürgen, Siegrist, Johannes, Singh-Manoux, Archana, Steptoe, Andrew, Suominen, Sakari B, Theorell, Töres, Vahtera, Jussi, Wagner, Gert G, Westerholm, Peter J M, Westerlund, Hugo, and Kivimäki, Mika

Published
2015

15. Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank

Author

Nyberg, Solja T., primary, Batty, G David, additional, Pentti, Jaana, additional, Madsen, Ida E H, additional, Alfredsson, Lars, additional, Bjorner, Jakob B., additional, Borritz, Marianne, additional, Burr, Hermann, additional, Ervasti, Jenni, additional, Goldberg, Marcel, additional, Jokela, Markus, additional, Knutsson, Anders, additional, Koskinen, Aki, additional, Lallukka, Tea, additional, Lindbohm, Joni V., additional, Nielsen, Martin L., additional, Oksanen, Tuula, additional, Pejtersen, Jan H., additional, Pietiläinen, Olli, additional, Rahkonen, Ossi, additional, Rugulies, Reiner, additional, Shipley, Martin J., additional, Sipilä, Pyry N., additional, Sørensen, Jeppe K., additional, Stenholm, Sari, additional, Suominen, Sakari, additional, Väänänen, Ari, additional, Vahtera, Jussi, additional, Virtanen, Marianna, additional, Westerlund, Hugo, additional, Zins, Marie, additional, Singh-Manoux, Archana, additional, and Kivimäki, Mika, additional

Published
2022
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16. How Bullying Involvement Is Associated with the Distribution of Parental Background and with Subjective Health Complaints among Swedish Boys and Girls

Author

Carlerby, Heidi, Viitasara, Eija, Knutsson, Anders, and Gadin, Katja Gillander

Abstract

This study aimed to analyze how bullying involvement is associated with the distribution of parental background and with subjective health complaints (SHC) among Swedish boys and girls. Data were collected from the World Health Organization, Health Behavior in School-aged Children (WHO/HBSC) survey, measurement years 1997/1998, 2001/2002 and 2005/2006. A total of 11,972 boys (50.6%) and girls (49.4%) in grades five, seven and nine participated in the study. The adolescents were categorized in subgroups according to parental background: Swedish (80.1%), mixed (10.5%) and foreign (9.7%). Multivariate logistic regressions were used to estimate remaining risk of SHC in the categories of bullying involvement. The frequencies of bullying involvement once or more were: none involved (74.8%), victims (10.6%), bullies (10.3%) and bully/victims (4.4%). Six out of ten involved in bullying were boys. Boys of foreign background were more involved as bullies compared to boys of mixed or Swedish background. Girls of foreign background were more involved in all three categories of bullying than girls of mixed or Swedish background. Increased risk of SHC was estimated among all adolescents involved in bullying, with highest OR in the category of bully/victims, OR 3.95 (CI 3.13-4.97) for the boys and OR 4.51 (CI 4.51-6.40) for the girls. The multivariate models were stable even after adjustment for socio-demographics. There are some associations between bullying involvement and parental background. Regardless of parental background, family affluence, family structure and gender, all adolescents involved in bullying are at increased risk of SHC.

Published
2013
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17. Association of alcohol use with years lived without major chronic diseases : A multicohort study from the IPD-Work consortium and UK Biobank

Author

Nyberg, Solja T., Batty, G. David, Pentti, Jaana, Madsen, Ida E H, Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Ervasti, Jenni, Goldberg, Marcel, Jokela, Markus, Knutsson, Anders, Koskinen, Aki, Lallukka, Tea, Lindbohm, Joni V., Nielsen, Martin L., Oksanen, Tuula, Pejtersen, Jan H., Pietiläinen, Olli, Rahkonen, Ossi, Rugulies, Reiner, Shipley, Martin J., Sipilä, Pyry N., Sørensen, Jeppe K., Stenholm, Sari, Suominen, Sakari, Väänänen, Ari, Vahtera, Jussi, Virtanen, Marianna, Westerlund, Hugo, Zins, Marie, Singh-Manoux, Archana, Kivimäki, Mika, Nyberg, Solja T., Batty, G. David, Pentti, Jaana, Madsen, Ida E H, Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Ervasti, Jenni, Goldberg, Marcel, Jokela, Markus, Knutsson, Anders, Koskinen, Aki, Lallukka, Tea, Lindbohm, Joni V., Nielsen, Martin L., Oksanen, Tuula, Pejtersen, Jan H., Pietiläinen, Olli, Rahkonen, Ossi, Rugulies, Reiner, Shipley, Martin J., Sipilä, Pyry N., Sørensen, Jeppe K., Stenholm, Sari, Suominen, Sakari, Väänänen, Ari, Vahtera, Jussi, Virtanen, Marianna, Westerlund, Hugo, Zins, Marie, Singh-Manoux, Archana, and Kivimäki, Mika

Abstract

Background Heavy alcohol consumption increases the risk of several chronic diseases. In this multicohort study, we estimated the number of life-years without major chronic diseases according to different characteristics of alcohol use. Methods In primary analysis, we pooled individual-level data from up to 129,942 adults across 12 cohort studies with baseline data collection on alcohol consumption, drinking patterns, and history between 1986 and 2005 (the IPD-Work Consortium). Self-reported alcohol consumption was categorised according to UK guidelines – non-drinking (never or former drinkers); moderate consumption (1–14 units); heavy consumption (>14 units per week). We further subdivided moderate and heavy drinkers by binge drinking pattern (alcohol-induced loss of consciousness). In addition, we assessed problem drinking using linked data on hospitalisations due to alcohol abuse or poisoning. Follow-up for chronic diseases for all participants included incident type 2 diabetes, coronary heart disease, stroke, cancer, and respiratory disease (asthma and chronic obstructive pulmonary disease) as ascertained via linkage to national morbidity and mortality registries, repeated medical examinations, and/or self-report. We estimated years lived without any of these diseases between 40 and 75 years of age according to sex and characteristics of alcohol use. We repeated the main analyses using data from 427,621 participants in the UK Biobank cohort study. Findings During 1·73 million person-years at risk, 22,676 participants in IPD-Work cohorts developed at least one chronic condition. From age 40 to 75 years, never-drinkers [men: 29·3 (95%CI 27·9–30·8) years, women 29·8 (29·2–30·4) years)] and moderate drinkers with no binge drinking habit [men 28·7 (28·4–29·0) years, women 29·6 (29·4–29·7) years] had the longest disease-free life span. A much shorter disease-free life span was apparent in participants who experienced alcohol poisoning [men 23·4 (20·9–26·0) years, wo

Published
2022
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18. Association of alcohol use with years lived without major chronic diseases:A multicohort study from the IPD-Work consortium and UK Biobank

Author

Nyberg, Solja T., Batty, G. David, Pentti, Jaana, Madsen, Ida E. H., Alfredsson, Lars, Bjørner, Jakob B., Borritz, Marianne, Burr, Hermann, Ervasti, Jenni, Goldberg, Marcel, Jokela, Markus, Knutsson, Anders, Koskinen, Aki, Lallukka, Tea, Lindbohm, Joni, Nielsen, Martin L., Oksanen, Tuula, Pejtersen, Jan H., Pietilainen, Olli, Rahkonen, Ossi, Rugulies, Reiner, Shipley, Martin J., Sipila, Pyry N., Sorensen, Jeppe K., Stenholm, Sari, Suominen, Sakari, Vaananen, Ari, Vahtera, Jussi, Virtanen, Marianna, Westerlund, Hugo, Zins, Marie, Singh-Manoux, Archana, Kivimaki, Mika, Nyberg, Solja T., Batty, G. David, Pentti, Jaana, Madsen, Ida E. H., Alfredsson, Lars, Bjørner, Jakob B., Borritz, Marianne, Burr, Hermann, Ervasti, Jenni, Goldberg, Marcel, Jokela, Markus, Knutsson, Anders, Koskinen, Aki, Lallukka, Tea, Lindbohm, Joni, Nielsen, Martin L., Oksanen, Tuula, Pejtersen, Jan H., Pietilainen, Olli, Rahkonen, Ossi, Rugulies, Reiner, Shipley, Martin J., Sipila, Pyry N., Sorensen, Jeppe K., Stenholm, Sari, Suominen, Sakari, Vaananen, Ari, Vahtera, Jussi, Virtanen, Marianna, Westerlund, Hugo, Zins, Marie, Singh-Manoux, Archana, and Kivimaki, Mika

Abstract

Background Heavy alcohol consumption increases the risk of several chronic diseases. In this multicohort study, we estimated the number of life-years without major chronic diseases according to different characteristics of alcohol use.Methods In primary analysis, we pooled individual-level data from up to 129,942 adults across 12 cohort studies with baseline data collection on alcohol consumption, drinking patterns, and history between 1986 and 2005 (the IPD-Work Consortium). Self-reported alcohol consumption was categorised according to UK guidelines - non-drinking (never or former drinkers); moderate consumption (1-14 units); heavy consumption (>14 units per week). We further subdivided moderate and heavy drinkers by binge drinking pattern (alcohol-induced loss of consciousness). In addition, we assessed problem drinking using linked data on hospitalisations due to alcohol abuse or poisoning. Follow-up for chronic diseases for all participants included incident type 2 diabetes, coronary heart disease, stroke, cancer, and respiratory disease (asthma and chronic obstructive pulmonary disease) as ascertained via linkage to national morbidity and mortality registries, repeated medical examinations, and/or self-report. We estimated years lived without any of these diseases between 40 and 75 years of age according to sex and characteristics of alcohol use. We repeated the main analyses using data from 427,621 participants in the UK Biobank cohort study.Findings During 1.73 million person-years at risk, 22,676 participants in IPD-Work cohorts developed at least one chronic condition. From age 40 to 75 years, never-drinkers [men: 29.3 (95%CI 27.9-30.8) years, women 29.8 (29.2 - 30.4) years)] and moderate drinkers with no binge drinking habit [men 28.7 (28.4-29.0) years, women 29.6 (29.4-29.7) years] had the longest disease-free life span. A much shorter disease-free life span was apparent in participants who experienced alcohol poisoning [men 23.4 (20.

Published
2022

25. Ischemic stroke and shift work

Author

Hermansson, Jonas, Gådin, Katja Gillander, Karlsson, Berndt, Lindahl, Bernt, Stegmayr, Birgitta, and Knutsson, Anders

Published
2007

27. Long working hours and risk of 50 health conditions and mortality outcomes: a multicohort study in four European countries

Author

Ervasti, Jenni, primary, Pentti, Jaana, additional, Nyberg, Solja T., additional, Shipley, Martin J., additional, Leineweber, Constanze, additional, Sørensen, Jeppe K., additional, Alfredsson, Lars, additional, Bjorner, Jakob B., additional, Borritz, Marianne, additional, Burr, Hermann, additional, Knutsson, Anders, additional, Madsen, Ida E.H., additional, Magnusson Hanson, Linda L., additional, Oksanen, Tuula, additional, Pejtersen, Jan H., additional, Rugulies, Reiner, additional, Suominen, Sakari, additional, Theorell, Töres, additional, Westerlund, Hugo, additional, Vahtera, Jussi, additional, Virtanen, Marianna, additional, Batty, G. David, additional, and Kivimäki, Mika, additional

Published
2021
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28. Validating abbreviated measures of effort-reward imbalance at work in European cohort studies: the IPD-Work consortium

Author

Siegrist, Johannes, Dragano, Nico, Nyberg, Solja T., Lunau, Thorsten, Alfredsson, Lars, Erbel, Raimund, Fahlén, Göran, Goldberg, Marcel, Jöckel, Karl-Heinz, Knutsson, Anders, Leineweber, Constanze, Magnusson Hanson, Linda L., Nordin, Maria, Rugulies, Reiner, Schupp, Jürgen, Singh-Manoux, Archana, Theorell, Töres, Wagner, Gert G., Westerlund, Hugo, Zins, Marie, Heikkilä, Katriina, Fransson, Eleonor I., and Kivimäki, Mika

Published
2014
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34. Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies

Author

Kivimäki, Mika, primary, Walker, Keenan A, additional, Pentti, Jaana, additional, Nyberg, Solja T, additional, Mars, Nina, additional, Vahtera, Jussi, additional, Suominen, Sakari B, additional, Lallukka, Tea, additional, Rahkonen, Ossi, additional, Pietiläinen, Olli, additional, Koskinen, Aki, additional, Väänänen, Ari, additional, Kalsi, Jatinderpal K, additional, Goldberg, Marcel, additional, Zins, Marie, additional, Alfredsson, Lars, additional, Westerholm, Peter J M, additional, Knutsson, Anders, additional, Theorell, Töres, additional, Ervasti, Jenni, additional, Oksanen, Tuula, additional, Sipilä, Pyry N, additional, Tabak, Adam G, additional, Ferrie, Jane E, additional, Williams, Stephen A, additional, Livingston, Gill, additional, Gottesman, Rebecca F, additional, Singh-Manoux, Archana, additional, Zetterberg, Henrik, additional, and Lindbohm, Joni V, additional

Published
2021
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38. Job Strain and the Risk of Stroke: An Individual-Participant Data Meta-Analysis

Author

Fransson, Eleonor I., Nyberg, Solja T., Heikkilä, Katriina, Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Dragano, Nico, A. Geuskens, Goedele, Goldberg, Marcel, Hamer, Mark, Hooftman, Wendela E., Houtman, Irene L., Joensuu, Matti, Jokela, Markus, Knutsson, Anders, Koskenvuo, Markku, Koskinen, Aki, Kumari, Meena, Leineweber, Constanze, Lunau, Thorsten, Madsen, Ida E.H., Hanson, Linda L. Magnusson, Nielsen, Martin L., Nordin, Maria, Oksanen, Tuula, Pentti, Jaana, Pejtersen, Jan H., Rugulies, Reiner, Salo, Paula, Shipley, Martin J., Steptoe, Andrew, Suominen, Sakari B., Theorell, Töres, Toppinen-Tanner, Salla, Vahtera, Jussi, Virtanen, Marianna, Väänänen, Ari, Westerholm, Peter J.M., Westerlund, Hugo, Zins, Marie, Britton, Annie, Brunner, Eric J., Singh-Manoux, Archana, Batty, G. David, and Kivimäki, Mika

Published
2015
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40. Cognitive stimulation in the workplace, plasma proteins, and risk of dementia : three analyses of population cohort studies

Author

Kivimaki, Mika, Walker, Keenan A., Pentti, Jaana, Nyberg, Solja, Mars, Nina, Vahtera, Jussi, Suominen, Sakari B., Lallukka, Tea, Rahkonen, Ossi, Pietilainen, Olli, Koskinen, Aki, Vaananen, Ari, Kalsi, Jatinderpal K., Goldberg, Marcel, Zins, Marie, Alfredsson, Lars, Westerholm, Peter J. M., Knutsson, Anders, Theorell, Tores, Ervasti, Jenni, Oksanen, Tuula, Sipila, Pyry N., Tabak, Adam G., Ferrie, Jane E., Williams, Stephen A., Livingston, Gill, Gottesman, Rebecca F., Singh-Manoux, Archana, Zetterberg, Henrik, Lindbohm, Joni, V, Kivimaki, Mika, Walker, Keenan A., Pentti, Jaana, Nyberg, Solja, Mars, Nina, Vahtera, Jussi, Suominen, Sakari B., Lallukka, Tea, Rahkonen, Ossi, Pietilainen, Olli, Koskinen, Aki, Vaananen, Ari, Kalsi, Jatinderpal K., Goldberg, Marcel, Zins, Marie, Alfredsson, Lars, Westerholm, Peter J. M., Knutsson, Anders, Theorell, Tores, Ervasti, Jenni, Oksanen, Tuula, Sipila, Pyry N., Tabak, Adam G., Ferrie, Jane E., Williams, Stephen A., Livingston, Gill, Gottesman, Rebecca F., Singh-Manoux, Archana, Zetterberg, Henrik, and Lindbohm, Joni, V

Abstract

OBJECTIVES To examine the association between cognitively stimulating work and subsequent risk of dementia and to identify protein pathways for this association. DESIGN Multicohort study with three sets of analyses. SETTING United Kingdom, Europe, and the United States. PARTICIPANTS Three associations were examined: cognitive stimulation and dementia risk in 107 896 participants from seven population based prospective cohort studies from the IPD-Work consortium (individual participant data meta-analysis in working populations); cognitive stimulation and proteins in a random sample of 2261 participants from one cohort study; and proteins and dementia risk in 13 656 participants from two cohort studies. MAIN OUTCOME MEASURES Cognitive stimulation was measured at baseline using standard questionnaire instruments on active versus passive jobs and at baseline and over time using a job exposure matrix indicator. 4953 proteins in plasma samples were scanned. Follow-up of incident dementia varied between 13.7 to 30.1 years depending on the cohort. People with dementia were identified through linked electronic health records and repeated clinical examinations. RESULTS During 1.8 million person years at risk, 1143 people with dementia were recorded. The risk of dementia was found to be lower for participants with high compared with low cognitive stimulation at work (crude incidence of dementia per 10 000 person years 4.8 in the high stimulation group and 7.3 in the low stimulation group, age and sex adjusted hazard ratio 0.77, 95% confidence interval 0.65 to 0.92, heterogeneity in cohort specific estimates I2=0%, P=0.99). This association was robust to additional adjustment for education, risk factors for dementia in adulthood (smoking, heavy alcohol consumption, physical inactivity, job strain, obesity, hypertension, and prevalent diabetes at baseline), and cardiometabolic diseases (diabetes, coronary heart disease, stroke) before dementia diagnosis (fully adjusted hazard ra

Published
2021
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41. Long working hours and risk of 50 health conditions and mortality outcomes : a multicohort study in four European countries

Author

Ervasti, Jenni, Pentti, Jaana, Nyberg, Solja T., Shipley, Martin J., Leineweber, Constanze, Sørensen, Jeppe K., Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Knutsson, Anders, Madsen, Ida E. H., Magnusson Hanson, Linda L., Oksanen, Tuula, Pejtersen, Jan H., Rugulies, Reiner, Suominen, Sakari, Theorell, Töres, Westerlund, Hugo, Vahtera, Jussi, Virtanen, Marianna, Batty, G. David, Kivimäki, Mika, Ervasti, Jenni, Pentti, Jaana, Nyberg, Solja T., Shipley, Martin J., Leineweber, Constanze, Sørensen, Jeppe K., Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Knutsson, Anders, Madsen, Ida E. H., Magnusson Hanson, Linda L., Oksanen, Tuula, Pejtersen, Jan H., Rugulies, Reiner, Suominen, Sakari, Theorell, Töres, Westerlund, Hugo, Vahtera, Jussi, Virtanen, Marianna, Batty, G. David, and Kivimäki, Mika

Abstract

Background: Studies on the association between long working hours and health have captured only a narrow range of outcomes (mainly cardiometabolic diseases and depression) and no outcome-wide studies on this topic are available. To achieve wider scope of potential harm, we examined long working hours as a risk factor for a wide range of disease and mortality endpoints. Methods: The data of this multicohort study were from two population cohorts from Finland (primary analysis, n=59 599) and nine cohorts (replication analysis, n=44 262) from Sweden, Denmark, and the UK, all part of the Individual-participant Meta-analysis in Working Populations (IPD-Work) consortium. Baseline-assessed long working hours (≥55 hours per week) were compared to standard working hours (35-40 h). Outcome measures with follow-up until age 65 years were 46 diseases that required hospital treatment or continuous pharmacotherapy, all-cause, and three cause-specific mortality endpoints, ascertained via linkage to national health and mortality registers. Findings: 2747 (4·6%) participants in the primary cohorts and 3027 (6·8%) in the replication cohorts worked long hours. After adjustment for age, sex, and socioeconomic status, working long hours was associated with increased risk of cardiovascular death (hazard ratio 1·68; 95% confidence interval 1·08-2·61 in primary analysis and 1·52; 0·90-2·58 in replication analysis), infections (1·37; 1·13-1·67 and 1·45; 1·13-1·87), diabetes (1·18; 1·01-1·38 and 1·41; 0·98-2·02), injuries (1·22; 1·00-1·50 and 1·18; 0·98-1·18) and musculoskeletal disorders (1·15; 1·06-1·26 and 1·13; 1·00-1·27). Working long hours was not associated with all-cause mortality. Interpretation: Follow-up of 50 health outcomes in four European countries suggests that working long hours is associated with an elevated risk of early cardiovascular death and hospital-treated infections before age 65. Associations, albeit weak, were also observed with diabetes, musculoskeletal disorders, CC BY-NC-ND 4.0© 2021 The AuthorsCorresponding author: Jenni ErvastiFunding: NordForsk, the Medical Research Council, the National Institute on Aging, the Wellcome Trust, Academy of Finland, and Finnish Work Environment Fund.

Published
2021
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42. No association between moist oral snuff (snus) use and oral cancer : pooled analysis of nine prospective observational studies

Author

Araghi, M., Galanti, M. R., Lundberg, M., Liu, Z., Ye, W., Lager, A., Engström, G., Alfredsson, L., Knutsson, Anders, Norberg, M., Wennberg, P., Lagerros, Y. T., Bellocco, R., Pedersen, N. L., Östergren, P.-O., Magnusson, C., Araghi, M., Galanti, M. R., Lundberg, M., Liu, Z., Ye, W., Lager, A., Engström, G., Alfredsson, L., Knutsson, Anders, Norberg, M., Wennberg, P., Lagerros, Y. T., Bellocco, R., Pedersen, N. L., Östergren, P.-O., and Magnusson, C.

Abstract

Aims: Worldwide, smokeless-tobacco use is a major risk factor for oral cancer. Evidence regarding the particular association between Swedish snus use and oral cancer is, however, less clear. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between snus use and oral cancer. Methods: A total of 418,369 male participants from nine cohort studies were followed up for oral cancer incidence through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. Results: During 9,201,647 person-years of observation, 628 men developed oral cancer. Compared to never-snus use, ever-snus use was not associated with oral cancer (adjusted HR 0.90, 95% CI: 0.74, 1.09). There were no clear trends in risk with duration or intensity of snus use, although lower intensity use (⩜ 4 cans/week) was associated with a reduced risk (HR 0.65, 95% CI: 0.45, 0.94). Snus use was not associated with oral cancer among never smokers (HR 0.87, 95% CI: 0.57, 1.32). Conclusions: Swedish snus use does not appear to be implicated in the development of oral cancer in men.

Published
2021
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43. Long working hours and risk of 50 health conditions and mortality outcomes:a multicohort study in four European countries

Author

Ervasti, Jenni, Pentti, Jaana, Nyberg, Solja T., Shipley, Martin J., Leineweber, Constanze, Sørensen, Jeppe K., Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Knutsson, Anders, Madsen, Ida E.H., Magnusson Hanson, Linda L., Oksanen, Tuula, Pejtersen, Jan H., Rugulies, Reiner, Suominen, Sakari, Theorell, Töres, Westerlund, Hugo, Vahtera, Jussi, Virtanen, Marianna, Batty, G. David, Kivimäki, Mika, Ervasti, Jenni, Pentti, Jaana, Nyberg, Solja T., Shipley, Martin J., Leineweber, Constanze, Sørensen, Jeppe K., Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Knutsson, Anders, Madsen, Ida E.H., Magnusson Hanson, Linda L., Oksanen, Tuula, Pejtersen, Jan H., Rugulies, Reiner, Suominen, Sakari, Theorell, Töres, Westerlund, Hugo, Vahtera, Jussi, Virtanen, Marianna, Batty, G. David, and Kivimäki, Mika

Abstract

Background: Studies on the association between long working hours and health have captured only a narrow range of outcomes (mainly cardiometabolic diseases and depression) and no outcome-wide studies on this topic are available. To achieve wider scope of potential harm, we examined long working hours as a risk factor for a wide range of disease and mortality endpoints. Methods: The data of this multicohort study were from two population cohorts from Finland (primary analysis, n=59 599) and nine cohorts (replication analysis, n=44 262) from Sweden, Denmark, and the UK, all part of the Individual-participant Meta-analysis in Working Populations (IPD-Work) consortium. Baseline-assessed long working hours (≥55 hours per week) were compared to standard working hours (35-40 h). Outcome measures with follow-up until age 65 years were 46 diseases that required hospital treatment or continuous pharmacotherapy, all-cause, and three cause-specific mortality endpoints, ascertained via linkage to national health and mortality registers. Findings: 2747 (4·6%) participants in the primary cohorts and 3027 (6·8%) in the replication cohorts worked long hours. After adjustment for age, sex, and socioeconomic status, working long hours was associated with increased risk of cardiovascular death (hazard ratio 1·68; 95% confidence interval 1·08-2·61 in primary analysis and 1·52; 0·90-2·58 in replication analysis), infections (1·37; 1·13-1·67 and 1·45; 1·13-1·87), diabetes (1·18; 1·01-1·38 and 1·41; 0·98-2·02), injuries (1·22; 1·00-1·50 and 1·18; 0·98-1·18) and musculoskeletal disorders (1·15; 1·06-1·26 and 1·13; 1·00-1·27). Working long hours was not associated with all-cause mortality. Interpretation: Follow-up of 50 health outcomes in four European countries suggests that working long hours is associated with an elevated risk of early cardiovascular death and hospital-treated infections before age 65. Associations, albeit weak, were also observed with diabetes, musculoskeletal disord

Published
2021

47. Job Strain as a Risk Factor for Type 2 Diabetes: A Pooled Analysis of 124,808 Men and Women

Author

Nyberg, Solja T., Fransson, Eleonor I., Heikkilä, Katriina, Ahola, Kirsi, Alfredsson, Lars, Bjorner, Jakob B., Borritz, Marianne, Burr, Hermann, Dragano, Nico, Goldberg, Marcel, Hamer, Mark, Jokela, Markus, Knutsson, Anders, Koskenvuo, Markku, Koskinen, Aki, Kouvonen, Anne, Leineweber, Constanze, Madsen, Ida E.H., Magnusson Hanson, Linda L., Marmot, Michael G., Nielsen, Martin L., Nordin, Maria, Oksanen, Tuula, Pejtersen, Jan H., Pentti, Jaana, Rugulies, Reiner, Salo, Paula, Siegrist, Johannes, Steptoe, Andrew, Suominen, Sakari, Theorell, Töres, Väänänen, Ari, Vahtera, Jussi, Virtanen, Marianna, Westerholm, Peter J.M., Westerlund, Hugo, Zins, Marie, Batty, G. David, Brunner, Eric J., Ferrie, Jane E., Singh-Manoux, Archana, and Kivimäki, Mika

Published
2014
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50. Job Strain and Health-Related Lifestyle: Findings From an Individual-Participant Meta-Analysis of 118 000 Working Adults

Author

Heikkilä, Katriina, Fransson, Eleonor I, Nyberg, Solja T, Zins, Marie, Westerlund, Hugo, Westerholm, Peter, Virtanen, Marianna, Vahtera, Jussi, Suominen, Sakari, Steptoe, Andrew, Salo, Paula, Pentti, Jaana, Oksanen, Tuula, Nordin, Maria, Marmot, Michael G, Lunau, Thorsten, Ladwig, Karl-Heinz, Koskenvuo, Markku, Knutsson, Anders, Kittel, France, Jöckel, Karl-Heinz, Goldberg, Marcel, Erbel, Raimund, Dragano, Nico, DeBacquer, Dirk, Clays, Els, Casini, Annalisa, Alfredsson, Lars, Ferrie, Jane E, Singh-Manoux, Archana, Batty, G David, and Kivimäki, Mika

Published
2013
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