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1. Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol

Author

Crowley, James J, Cappi, Carolina, Ochoa-Panaifo, Marcos E, Frederick, Renee M, Kook, Minjee, Wiese, Andrew D, Rancourt, Diana, Atkinson, Elizabeth G, Giusti-Rodriguez, Paola, Anderberg, Jacey L, Abramowitz, Jonathan S, Adorno, Victor R, Aguirre, Cinthia, Alves, Gustavo S, Alves, Gilberto S, Ancalade, NaEshia, Arellano Espinosa, Alejandro A, Arnold, Paul D, Ayton, Daphne M, Barbosa, Izabela G, Barón Castano, Laura Marcela, Barrera, Cynthia N, Belén Prieto, María, Berardo, María Celeste, Berrones, Dayan, Best, John R, Bigdeli, Tim B, Burton, Christie L, Callahan, Jennifer L, Carneiro, Maria Cecília B, Cepeda, Sandra L, Chazelle, Evelyn, Chire, Jessica M, Churruca Munoz, Macarena, Claisse Quiroz, Pamela, Cobite, Journa, Comer, Jonathan S, Costa, Daniel L, Crosbie, Jennifer, Cruz, Victor O, Dager, Guillermo, Daza, Luisa F, de la Rosa-Gómez, Anabel, del Río, Daniela, Delage, Fernanda Z, Dreher, Carolina B, Fay, Lucila, Fazio, Tomas, Ferrão, Ygor A, Ferreira, Gabriela M, Figueroa, Edith G, Fontenelle, Leonardo F, Forero, Diego A, Fragoso, Daniele TH, Gadad, Bharathi S, Garrison, Sheldon R, González, Andres, Gonzalez, Laura D, González, Marco A, Gonzalez-Barrios, Polaris, Goodman, Wayne, Guintivano, Jerry, Guttfreund, Daniel G, Guzick, Andrew G, Halvorsen, Matthew W, Hovey, Joseph D, Janssen-Aguilar, Reinhard, Jensen, Matias, Jimenez Reynolds, Alexandra Z, Juárez Lujambio, Joali Alexandra, Khalfe, Nasim, Knutsen, Madison A, Lack, Caleb, Lanzagorta, Nuria, Lima, Monicke O, Longhurst, Melanie O, Lozada Martinez, David A, Luna, Elba S, Marques, Andrea H, Martinez, Molly, Matos, Maria de Los Angeles, Maye, Caitlyn E, McGuire, Joseph F, Menezes, Gabriela, Minaya, Charlene, Miño, Tomás, Mithani, Sara M, Montes de Oca, Circe, Morales-Rivero, Alonso, Moreira-de-Oliveira, Maria E, Morris, Olivia J, Muñoz, Sandra I, Naqqash, Zainab, Núñez Bracho, Ambar A, Núñez Bracho, Belinda E, Ochoa Rojas, Maria Corina, Olavarria Castaman, Luis A, Ortega, Iliana, Patel, Darpan I, Patrick, Ainsley K, Paz y Mino, Mariel, Perales Orellana, Jose L, Perdigão Stumpf, Bárbara, Peregrina, Tamara, Pérez Duarte, Tania, Piacsek, Kelly L, Placencia, Maritza, Quarantini, Lucas C, Quarantini-Alvim, Yana, Ramos, Renato T, Ramos, Iaroslava C, Ramos, Vanessa R, Ramsey, Kesley A, Ray, Elise V, Richter, Margaret A, Riemann, Bradley C, Rivas, Juan C, Rosario, Maria C, Ruggero, Camilo J, Ruiz-Chow, Angel A, Ruiz-Velasco, Alejandra, Sampaio, Aline S, Saraiva, Leonardo C, Schachar, Russell J, Schneider, Sophie C, Schweissing, Ethan J, Seligman, Laura D, Shavitt, Roseli G, Soileau, Keaton J, Stewart, S. Evelyn, Storch, Shaina B, Strouphauer, Emily R, Timpano, Kiara R, Treviño-de la Garza, Beatriz, Vargas-Medrano, Javier, Vásquez, María I, Vidal Martinez, Guadalupe, Weinzimmer, Saira A, Yanez, Mauricio A, Zai, Gwyneth, Zapata-Restrepo, Lina M, Zappa, Luz M, Zepeda-Burgos, Raquel M, Zoghbi, Anthony W, Miguel, Euripedes C, Rodriguez, Carolyn I, Martinez Mallen, Mayra C, Moya, Pablo R, Borda, Tania, Moyano, María Beatriz, Mattheisen, Manuel, Pereira, Stacey, Lázaro-Muñoz, Gabriel, Martinez-Gonzalez, Karen G, Pato, Michele T, Nicolini, Humberto, and Storch, Eric A

Subjects
Article
Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org ). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Published
2023

2. Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol

Author

Crowley, James J., Cappi, Carolina, Ochoa‐Panaifo, Marcos E., Frederick, Renee M., Kook, Minjee, Wiese, Andrew D., Rancourt, Diana, Atkinson, Elizabeth G., Giusti‐Rodriguez, Paola, Anderberg, Jacey L., Abramowitz, Jonathan S, Adorno, Victor R, Aguirre, Cinthia, Alves, Gilberto S, Alves, Gustavo S, Ancalade, NaEshia, Anderberg, Jacey L, Arellano Espinosa, Alejandro A, Arnold, Paul D, Atkinson, Elizabeth G, Ayton, Daphne M, Barbosa, Izabela G, Castano, Laura Marcela Barón, Barrera, Cynthia N, Berardo, María Celeste, Berrones, Dayan, Best, John R, Bigdeli, Tim B, Borda, Tania, Burton, Christie L, Buxbaum, Joseph D, Callahan, Jennifer L, Cappi, Carolina, Carneiro, Maria Cecília B, Cepeda, Sandra L, Chazelle, Evelyn, Chire, Jessica M, Munoz, Macarena Churruca, Quiroz, Pamela Claisse, Cobite, Journa, Comer, Jonathan S, Costa, Daniel L, Crosbie, Jennifer, Crowley, James J, Cruz, Victor O, Dager, Guillermo, Daza, Luisa F, Rosa‐Gómez, Anabel, Río, Daniela, Delage, Fernanda Z, Dreher, Carolina B, Fay, Lucila, Fazio, Tomas, Ferrão, Ygor A, Ferreira, Gabriela M, Figueroa, Edith G, Fontenelle, Leonardo F, Forero, Diego A, Fragoso, Daniele TH, Frederick, Renee M, Gadad, Bharathi S, Garrison, Sheldon R, Giusti‐Rodriguez, Paola, Gonzalez, Laura D, González, Andres, González, Marco A, Gonzalez‐Barrios, Polaris, Goodman, Wayne, Grice, Dorothy E, Guintivano, Jerry, Guttfreund, Daniel G, Guzick, Andrew G, Halvorsen, Matthew W, Hovey, Joseph D, Huang, Hailiang, Irreño‐Sotomonte, Jonathan, Janssen‐Aguilar, Reinhard, Jensen, Matias, Jimenez Reynolds, Alexandra Z, Lujambio, Joali Alexandra Juárez, Khalfe, Nasim, Knutsen, Madison A, Kook, Minjee, Lack, Caleb, Lanzagorta, Nuria, Lázaro‐Muñoz, Gabriel, Lima, Monicke O, Longhurst, Melanie O, Lozada Martinez, David A, Luna, Elba S, Marques, Andrea H, Martinez, Molly, Martinez Mallen, Mayra C, Martinez‐Gonzalez, Karen G, Los Angeles Matos, Maria, Mattheisen, Manuel, Maye, Caitlyn E, McGuire, Joseph F, Menezes, Gabriela, Miguel, Euripedes C, Minaya, Charlene, Miño, Tomás, Mithani, Sara M, Oca, Circe Montes, Morales‐Rivero, Alonso, Moreira‐de‐Oliveira, Maria E, Morris, Olivia J, Moya, Pablo R, Moyano, María Beatriz, Muñoz, Sandra I, Naqqash, Zainab, Nicolini, Humberto, Núñez Bracho, Ambar A, Núñez Bracho, Belinda E, Rojas, Maria Corina Ochoa, Ochoa‐Panaifo, Marcos E, Olavarria Castaman, Luis A, Balmaceda, Trinidad Olivos, Ortega, Iliana, Patel, Darpan I, Pato, Michele T, Patrick, Ainsley K, Mino, Mariel Paz y, Perales Orellana, Jose L, Stumpf, Bárbara Perdigão, Peregrina, Tamara, Pereira, Stacey, Duarte, Tania Pérez, Piacsek, Kelly L, Placencia, Maritza, Prieto, María Belén, Quarantini, Lucas C, Quarantini‐Alvim, Yana, Ramos, Iaroslava C, Ramos, Renato T, Ramos, Vanessa R, Ramsey, Kesley A, Rancourt, Diana, Ray, Elise V, Richter, Margaret A, Riemann, Bradley C, Rivas, Juan C, Rodriguez, Carolyn I, Rosario, Maria C, Ruggero, Camilo J, Ruiz‐Chow, Angel A, Ruiz‐Velasco, Alejandra, Sagarnaga, Melisa N, Sampaio, Aline S, Saraiva, Leonardo C, Schachar, Russell J, Schneider, Sophie C, Schweissing, Ethan J, Seligman, Laura D, Shavitt, Roseli G, Soileau, Keaton J, Stewart, S. Evelyn, Storch, Eric A, Storch, Shaina B, Strouphauer, Emily R, Cuevas, Vissente Tapia, Timpano, Kiara R, Garza, Beatriz Treviño‐de, Vallejo‐Silva, Alexie, Vargas‐Medrano, Javier, Vásquez, María I, Martinez, Guadalupe Vidal, Weinzimmer, Saira A, Wiese, Andrew D, Yanez, Mauricio A, Zai, Gwyneth, Zapata‐Restrepo, Lina M, Zappa, Luz M, Zepeda‐Burgos, Raquel M, Zoghbi, Anthony W, Sampaio, Aline Santos, Hounie, Ana Gabriela, Ribeiro, Ana Paula, Souza e Silva, Angela Rodrigues, Martinho, Ariane Fadel, Stumpf, Bárbara Luciane Perdigão, Melo Fadel, Bianca Torres Mendonça, Porto, Camila Vale, Chacur, Carina Freitas, Loureiro, Carla Pereira, Dreher, Carolina Blaya, Cappi, Carolina, Bortoncello, Cristiane Flôres, Conceição Costa, Daniel Lucas, Fragoso, Daniele Tamae Hashimoto, Miguel, Euripedes Constantino, Delage, Fernanda Zetola, Cervone, Flávia, Menezes, Gabriela Bezerra, Souza Barros, Gabriela Cirqueira, Ferreira, Gabriela Mourão, Alves, Gilberto Sousa, Alves, Gustavo Santiago, Caminha, Hugo, Barbosa, Izabela Guimarães, Cenci, Jaqueline, Muhlbauer, Julia Fernandes Eigenheer, Silva, Juliana Rigue, Saraiva, Leonardo Cardoso, Costa Fontenelle, Leonardo Franklin, Camba Lopez, Lígia S., Faro, Livi Ferreira Testoni, Moreira, Luan Pinheiro Domingues, Laurito, Luana Dumans, Castro Quarantini, Lucas, Samezima, Luciana Midori, Santos Martins, Luiz Felipe Guimarães, Oliveira, Marcos Vinícius Sousa, Mathis, Maria Alice, Lopes, Maria Carolina Paraíso, Carneiro, Maria Cecília, Rosário, Maria Conceição, Oliveira, Maria Eduarda Ismerio Moreira, Pinho, Marina Martorelli, Oliveira Lima, Monicke, Nagano, Nádia, Danna, Patrycia Chedid, Silva, Pedro Pereira Fortes, Jesus Cardoso, Raquel Fernandes, Christo, Renan Barbosa, Avila, Richard Chuquel Silveira, Radins, Rodrigo Bolsson, Shavitt, Roseli Gedanke, Santos Ribeiro, Samara, Silveira Meirelles, Tatiane Veríssimo, Aguiar, Thays Mendes, Silva Sousa, Theresa Kerolayne, Vieira, Thiago Blanco, Ramos, Vanessa Rogério, Vasconcellos, Veronica Huhne, Alvim, Yana Quarantini, Ferrão, Ygor Arzeno, Abramowitz, Jonathan S., Adorno, Victor R., Aguirre, Cinthia, Alves, Gilberto S., Alves, Gustavo S., Ancalade, NaEshia, Arellano Espinosa, Alejandro A., Arnold, Paul D., Ayton, Daphne M., Barbosa, Izabela G., Castano, Laura Marcela Barón, Barrera, Cynthia N., Berardo, María Celeste, Berrones, Dayan, Best, John R., Bigdeli, Tim B., Burton, Christie L., Buxbaum, Joseph D., Callahan, Jennifer L., Carneiro, Maria Cecília B., Cepeda, Sandra L., Chazelle, Evelyn, Chire, Jessica M., Munoz, Macarena Churruca, Quiroz, Pamela Claisse, Cobite, Journa, Comer, Jonathan S., Costa, Daniel L., Crosbie, Jennifer, Cruz, Victor O., Dager, Guillermo, Daza, Luisa F., Rosa‐Gómez, Anabel, Río, Daniela, Delage, Fernanda Z., Dreher, Carolina B., Fay, Lucila, Fazio, Tomas, Ferrão, Ygor A., Ferreira, Gabriela M., Figueroa, Edith G., Fontenelle, Leonardo F., Forero, Diego A., Fragoso, Daniele T. H., Gadad, Bharathi S., Garrison, Sheldon R., González, Andres, Gonzalez, Laura D., González, Marco A., Gonzalez‐Barrios, Polaris, Goodman, Wayne K., Grice, Dorothy E., Guintivano, Jerry, Guttfreund, Daniel G., Guzick, Andrew G., Halvorsen, Matthew W., Hovey, Joseph D., Huang, Hailiang, Irreño‐Sotomonte, Jonathan, Janssen‐Aguilar, Reinhard, Jensen, Matias, Jimenez Reynolds, Alexandra Z., Lujambio, Joali Alexandra Juárez, Khalfe, Nasim, Knutsen, Madison A., Lack, Caleb, Lanzagorta, Nuria, Lima, Monicke O., Longhurst, Melanie O., Lozada Martinez, David A., Luna, Elba S., Marques, Andrea H., Martinez, Molly S., Los Angeles Matos, Maria, Maye, Caitlyn E., McGuire, Joseph F., Menezes, Gabriela, Minaya, Charlene, Miño, Tomás, Mithani, Sara M., Oca, Circe Montes, Morales‐Rivero, Alonso, Moreira‐de‐Oliveira, Maria E., Morris, Olivia J., Muñoz, Sandra I., Naqqash, Zainab, Núñez Bracho, Ambar A., Núñez Bracho, Belinda E., Rojas, Maria Corina Ochoa, Olavarria Castaman, Luis A., Balmaceda, Trinidad Olivos, Ortega, Iliana, Patel, Darpan I., Patrick, Ainsley K., Paz y Mino, Mariel, Perales Orellana, Jose L., Stumpf, Bárbara Perdigão, Peregrina, Tamara, Duarte, Tania Pérez, Piacsek, Kelly L., Placencia, Maritza, Prieto, María Belén, Quarantini, Lucas C., Quarantini‐Alvim, Yana, Ramos, Renato T., Ramos, Iaroslava C., Ramos, Vanessa R., Ramsey, Kesley A., Ray, Elise V., Richter, Margaret A., Riemann, Bradley C., Rivas, Juan C., Rosario, Maria C., Ruggero, Camilo J., Ruiz‐Chow, Angel A., Ruiz‐Velasco, Alejandra, Sagarnaga, Melisa N., Sampaio, Aline S., Saraiva, Leonardo C., Schachar, Russell J., Schneider, Sophie C., Schweissing, Ethan J., Seligman, Laura D., Shavitt, Roseli G., Soileau, Keaton J., Stewart, S. Evelyn, Storch, Shaina B., Strouphauer, Emily R., Cuevas, Vissente Tapia, Timpano, Kiara R., Garza, Beatriz Treviño‐de, Vallejo‐Silva, Alexie, Vargas‐Medrano, Javier, Vásquez, María I., Martinez, Guadalupe Vidal, Weinzimmer, Saira A., Yanez, Mauricio A., Zai, Gwyneth, Zapata‐Restrepo, Lina M., Zappa, Luz M., Zepeda‐Burgos, Raquel M., Zoghbi, Anthony W., Miguel, Euripedes C., Rodriguez, Carolyn I., Martinez Mallen, Mayra C., Moya, Pablo R., Borda, Tania, Moyano, María Beatriz, Mattheisen, Manuel, Pereira, Stacey, Lázaro‐Muñoz, Gabriel, Martinez‐Gonzalez, Karen G., Pato, Michele T., Nicolini, Humberto, and Storch, Eric A.

Abstract

Obsessive‐compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long‐sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans‐ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans‐ancestry genomic analyses to accelerate the identification of OCD risk loci, fine‐map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Published
2024
Full Text
View/download PDF

3. Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol.

Author

Crowley JJ, Cappi C, Ochoa-Panaifo ME, Frederick RM, Kook M, Wiese AD, Rancourt D, Atkinson EG, Giusti-Rodriguez P, Anderberg JL, Abramowitz JS, Adorno VR, Aguirre C, Alves GS, Alves GS, Ancalade N, Espinosa AAA, Arnold PD, Ayton DM, Barbosa IG, Castano LMB, Barrera CN, Prieto MB, Berardo MC, Berrones D, Best JR, Bigdeli TB, Burton CL, Callahan JL, Carneiro MCB, Cepeda SL, Chazelle E, Chire JM, Munoz MC, Quiroz PC, Cobite J, Comer JS, Costa DL, Crosbie J, Cruz VO, Dager G, Daza LF, de la Rosa-Gómez A, Del Río D, Delage FZ, Dreher CB, Fay L, Fazio T, Ferrão YA, Ferreira GM, Figueroa EG, Fontenelle LF, Forero DA, Fragoso DT, Gadad BS, Garrison SR, González A, Gonzalez LD, González MA, Gonzalez-Barrios P, Goodman W, Guintivano J, Guttfreund DG, Guzick AG, Halvorsen MW, Hovey JD, Janssen-Aguilar R, Jensen M, Reynolds AZJ, Lujambio JAJ, Khalfe N, Knutsen MA, Lack C, Lanzagorta N, Lima MO, Longhurst MO, Martinez DAL, Luna ES, Marques AH, Martinez M, de Los Angeles Matos M, Maye CE, McGuire JF, Menezes G, Minaya C, Miño T, Mithani SM, de Oca CM, Morales-Rivero A, Moreira-de-Oliveira ME, Morris OJ, Muñoz SI, Naqqash Z, Bracho AAN, Bracho BEN, Rojas MCO, Castaman LAO, Ortega I, Patel DI, Patrick AK, Mino MPY, Orellana JLP, Stumpf BP, Peregrina T, Duarte TP, Piacsek KL, Placencia M, Quarantini LC, Quarantini-Alvim Y, Ramos RT, Ramos IC, Ramos VR, Ramsey KA, Ray EV, Richter MA, Riemann BC, Rivas JC, Rosario MC, Ruggero CJ, Ruiz-Chow AA, Ruiz-Velasco A, Sampaio AS, Saraiva LC, Schachar RJ, Schneider SC, Schweissing EJ, Seligman LD, Shavitt RG, Soileau KJ, Stewart SE, Storch SB, Strouphauer ER, Timpano KR, Treviño-de la Garza B, Vargas-Medrano J, Vásquez MI, Martinez GV, Weinzimmer SA, Yanez MA, Zai G, Zapata-Restrepo LM, Zappa LM, Zepeda-Burgos RM, Zoghbi AW, Miguel EC, Rodriguez CI, Mallen MCM, Moya PR, Borda T, Moyano MB, Mattheisen M, Pereira S, Lázaro-Muñoz G, Martinez-Gonzalez KG, Pato MT, Nicolini H, and Storch EA

Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Published
2023
Full Text
View/download PDF

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