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Your search keyword '"Knudsen, J. S."' showing total 8 results
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8 results on '"Knudsen, J. S."'

1. Prediction of difficult mask ventilation using a systematic assessment of risk factors vs. existing practice – a cluster randomised clinical trial in 94,006 patients

Author

Nørskov, A. K., Wetterslev, J., Rosenstock, C. V., Afshari, A., Astrup, G., Jakobsen, J. C., Thomsen, J. L., Lundstrøm, L. H., Bøttger, M., Ellekvist, M., Schousboe, B. M. B., Horn, A., Jørgensen, B. G., Lorentzen, K., Madsen, M. H., Knudsen, J. S., Thisted, B. K., Estrup, S., Mieritz, H. B., Klesse, T., Martinussen, H. J., Vedel, A. G., Maaløe, R., Bøsling, K. B., Kirkegaard, P. R. C., Ibáñez, C. R., Aleksandraviciute, G., Hansen, L. S., and Mantoni, T.

Published
2017
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2. Effects of using the simplified airway risk index vs usual airway assessment on unanticipated difficult tracheal intubation - a cluster randomized trial with 64,273 participants

Author

Nørskov, A. K., Wetterslev, J., Rosenstock, C. V., Afshari, A., Astrup, G., Jakobsen, J. C, Thomsen, J. L., Bøttger, M., Ellekvist, M., Schousboe, B. M. B., Horn, A., Jørgensen, B. G., Lorentzen, K., Madsen, M. H., Knudsen, J. S., Thisted, B. K., Estrup, S., Mieritz, H. B., Klesse, T., Martinussen, H. J., Vedel, A. G., Maaløe, R., Bøsling, K. B., Kirkegaard, P. R. C., Ibáñez, C. R., Aleksandraviciute, G., Hansen, L. S., Mantoni, T., and Lundstrøm, L. H.

Published
2016
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3. Effects of using the simplified airway risk index vs usual airway assessment on unanticipated difficult tracheal intubation - a cluster randomized trial with 64,273 participants

Author

Nørskov, A K, Wetterslev, J, Rosenstock, C V, Afshari, Arash, Astrup, G, Jakobsen, J C, Thomsen, J. L., Bøttger, Morten, Ellekvist, M, Schousboe, B M B, Horn, A, Jørgensen, B G, Lorentzen, K, Madsen, M H, Knudsen, J S, Thisted, B K, Estrup, S, Mieritz, H B, Klesse, T, Martinussen, H J, Vedel, A G, Maaløe, R, Bøsling, K B, Kirkegaard, P R C, Ibáñez, C R, Aleksandraviciute, G, Hansen, L S, Mantoni, T, Lundstrøm, L H, Nørskov, A K, Wetterslev, J, Rosenstock, C V, Afshari, Arash, Astrup, G, Jakobsen, J C, Thomsen, J. L., Bøttger, Morten, Ellekvist, M, Schousboe, B M B, Horn, A, Jørgensen, B G, Lorentzen, K, Madsen, M H, Knudsen, J S, Thisted, B K, Estrup, S, Mieritz, H B, Klesse, T, Martinussen, H J, Vedel, A G, Maaløe, R, Bøsling, K B, Kirkegaard, P R C, Ibáñez, C R, Aleksandraviciute, G, Hansen, L S, Mantoni, T, and Lundstrøm, L H

Abstract

BACKGROUND: Unanticipated difficult intubation remains a challenge in anaesthesia. The Simplified Airway Risk Index (SARI) is a multivariable risk model consisting of seven independent risk factors for difficult intubation. Our aim was to compare preoperative airway assessment based on the SARI with usual airway assessment.METHODS: From 01.10.2012 to 31.12.2013, 28 departments were cluster-randomized to apply the SARI model or usual airway assessment. The SARI group implemented the SARI model. The Non-SARI group continued usual airway assessment, thus reflecting a group of anaesthetists' heterogeneous individual airway assessments. Preoperative prediction of difficult intubation and actual intubation difficulties were registered in the Danish Anaesthesia Database for both groups. Patients who were preoperatively scheduled for intubation by advanced techniques (e.g. video laryngoscopy; flexible optic scope) were excluded from the primary analysis. Primary outcomes were the proportions of unanticipated difficult and unanticipated easy intubation.RESULTS: A total of 26 departments (15 SARI and 11 Non-SARI) and 64 273 participants were included. In the primary analyses 29 209 SARI and 30 305 Non-SARI participants were included.In SARI departments 2.4% (696) of the participants had an unanticipated difficult intubation vs 2.4% (723) in Non-SARI departments. Odds ratio (OR) adjusted for design variables was 1.03 (95% CI: 0.77-1.38). The proportion of unanticipated easy intubation was 1.42% (415) in SARI departments vs 1.00% (302) in Non-SARI departments. Adjusted OR was 1.26 (0.68-2.34).CONCLUSIONS: Using the SARI compared with usual airway assessment we detected no statistical significant changes in unanticipated difficult- or easy intubations.CLINICAL TRIAL REGISTRATION: NCT01718561.

Published
2016

5. Class III pistil-specific extensin-like proteins from tobacco have characteristics of arabinogalactan proteins.

Author

Bosch, M, Knudsen, J S, Derksen, J, and Mariani, C

Abstract

Class III pistil-specific extensin-like proteins (PELPIII) are specifically localized in the intercellular matrix of tobacco (Nicotiana tabacum) styles. After pollination the majority of PELPIII are translocated into the callosic layer and the callose plugs of the pollen tubes, which could suggest a function of PELPIII in pollen tube growth. PELPIII may represent one of the chemical and/or physical factors from the female sporophytic tissue that contributes to the difference between in vivo and in vitro pollen tube growth. PELPIII glycoproteins were purified and biochemically characterized. Because of their high proline (Pro) and hydroxy-Pro (Hyp) content, PELPIII proteins belong to the class of Pro/Hyp-rich glycoproteins. The carbohydrate moiety of PELPIII is attached through O-glycosidic linkages and comprises more than one-half the total glycoprotein. Deglycosylation of PELPIII revealed two backbones, both reacting with PELPIII-specific antibodies. N-terminal amino acid sequencing of these backbones showed that PELPIII is encoded by the MG14 and MG15 genes. Two heterogeneous N-terminal sequences of MG14 and MG15, both starting downstream of the predicted signal peptide cleavage site, seem to be present, which indicates a novel N-terminal processing. Monosaccharide analysis showed that the carbohydrate moiety of PELPIII almost completely consists of arabinose and galactose in an equal molar ratio. Carbohydrate linkage analysis showed terminal and 2-linked arabinofuranosyl residues, as well as terminal and 6-, 3-, and 3,6-linked galactopyranosyl residues to be present, indicating the presence of both extensin-like and Type II arabinogalactan oligosaccharide units. The ability of beta-glucosyl Yariv reagent to bind with PELPIII confirmed the arabinogalactan protein-like characteristics of these proteins.

Published
2001
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8. Effects of using the simplified airway risk index vs usual airway assessment on unanticipated difficult tracheal intubation - a cluster randomized trial with 64,273 participants.

Author

Nørskov AK, Wetterslev J, Rosenstock CV, Afshari A, Astrup G, Jakobsen JC, Thomsen JL, Bøttger M, Ellekvist M, Schousboe BM, Horn A, Jørgensen BG, Lorentzen K, Madsen MH, Knudsen JS, Thisted BK, Estrup S, Mieritz HB, Klesse T, Martinussen HJ, Vedel AG, Maaløe R, Bøsling KB, Kirkegaard PR, Ibáñez CR, Aleksandraviciute G, Hansen LS, Mantoni T, and Lundstrøm LH

Subjects
Adult, Aged, Airway Management adverse effects, Airway Management methods, Cluster Analysis, Double-Blind Method, Female, Humans, Intubation, Intratracheal adverse effects, Male, Middle Aged, Prognosis, Risk Assessment methods, Risk Factors, Treatment Failure, Intubation, Intratracheal methods, Preoperative Care methods
Abstract

Background: Unanticipated difficult intubation remains a challenge in anaesthesia. The Simplified Airway Risk Index (SARI) is a multivariable risk model consisting of seven independent risk factors for difficult intubation. Our aim was to compare preoperative airway assessment based on the SARI with usual airway assessment., Methods: From 01.10.2012 to 31.12.2013, 28 departments were cluster-randomized to apply the SARI model or usual airway assessment. The SARI group implemented the SARI model. The Non-SARI group continued usual airway assessment, thus reflecting a group of anaesthetists' heterogeneous individual airway assessments. Preoperative prediction of difficult intubation and actual intubation difficulties were registered in the Danish Anaesthesia Database for both groups. Patients who were preoperatively scheduled for intubation by advanced techniques (e.g. video laryngoscopy; flexible optic scope) were excluded from the primary analysis. Primary outcomes were the proportions of unanticipated difficult and unanticipated easy intubation., Results: A total of 26 departments (15 SARI and 11 Non-SARI) and 64 273 participants were included. In the primary analyses 29 209 SARI and 30 305 Non-SARI participants were included.In SARI departments 2.4% (696) of the participants had an unanticipated difficult intubation vs 2.4% (723) in Non-SARI departments. Odds ratio (OR) adjusted for design variables was 1.03 (95% CI: 0.77-1.38). The proportion of unanticipated easy intubation was 1.42% (415) in SARI departments vs 1.00% (302) in Non-SARI departments. Adjusted OR was 1.26 (0.68-2.34)., Conclusions: Using the SARI compared with usual airway assessment we detected no statistical significant changes in unanticipated difficult- or easy intubations., Clinical Trial Registration: NCT01718561., (© The Author 2016. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Published
2016
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