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Coherent Diffraction Imaging (CDI) is an experimental technique to get images of isolated structures by recording the light scattered off the sample. Thanks to the extremely bright and short coherent light pulses provided by X-ray Free Electron Lasers, CDI makes it possible to study nanostructures in the gas phase and get time-resolved snapshots of their ultrafast dynamics with unprecedented resolution. In principle, the sample density can be recovered from the scattered light field through a straightforward Fourier Transform operation. However, only the amplitude of the field is recorded, while the phase is lost during the measurement process and has to be retrieved by means of suitable, well-established, phase retrieval algorithms. We present the Memetic Phase Retrieval (MPR) method, an improved approach to the phase retrieval problem, which makes use of a combination of existing phase retrieval algorithms and evolutionary algorithms to mitigate the shortcomings of conventional approaches. We benchmark the method on experimental data acquired in two experimental campaigns at SwissFEL and European XFEL. Imaging results on isolated nanostructures reveal considerable stability of the algorithm's behavior on the input parameters, as well as the capability of identifying the solution in challenging conditions. A user-friendly implementation of the MPR method is released as open-source software, aiming at being a reference tool for the FEL imaging community., Comment: 37 pages, 13 figures. Software not yet released as open source. Software documentation under construction. Authors list up to date

Nonlinear wave mixing in the X-ray range can provide valuable insights into the structural and electron dynamics of atomic and molecular systems on ultrafast time scales, with state- and site-selectivity and atomic resolution. This promising experimental toolbox was so far limited by requiring at least one near-visible laser, thus preventing core-shell two-dimensional X-ray spectroscopy. In this work, we demonstrate the generation of background-free all-X-ray four-wave mixing (XFWM) signals from a dilute gaseous sample (Ne). The measured and simulated two-dimensional spectral maps ($\omega_{\text{in}},\omega_{\text{out}}$) show multiple contributions involving the coherent response from core electrons. Notably, two-color resonant XFWM signals, essential for generalized multi-color schemes that allow to locally probe the electronic excitation of matter, are observed in neutral Ne. Moreover, stimulated Ne$^+$ emission in each of the propagating X-ray pulses leads to an increase of the temporal coherence in a narrow-bandwidth, which results in the coherent mixing of three X-ray lasers. Preliminary X-ray excitation experiments making use of multi-color time-delayed X-ray pulses demonstrate temporal resolution capability and show a time dependency consistent with a signal dominated by resonant XFWM processes. This first all-X-ray four-wave-mixing approach represents a major breakthrough towards multidimensional X-ray correlation spectroscopy and the general application of nonlinear all-X-ray wave-mixing.

This paper presents bit-interleaved coded modulation metrics for joint estimation and detection in short block length channels, addressing scenarios with unknown channel state information and low training dimension density. We show that it is possible to enhance the performance and sensitivity through joint detection-estimation compared to standard receivers, especially when the channel state information is unknown and the density of the training dimensions is low. The performance analysis makes use of a full 5G transmitter and receiver chains for both Polar and LDPC coded transmissions paired with QPSK modulation scheme. We consider transmissions where reference signals are interleaved with data and both are transmitted over a small number of OFDM symbols so that near-perfect channel estimation cannot be achieved. This is particularly adapted to mini-slot transmissions for ultra-reliable, low-latency communications (URLLC) or for short packet random access use cases. Performance evaluation spans SIMO and SU-MIMO configurations, emphasizing the efficacy of BICM detection in realistic base station receiver scenarios. Our findings demonstrate that when the detection windows used in the metric units are on the order of four modulated symbols, the proposed receiver metrics can be used to achieve detection performance that is close to that of a coherent receiver with perfect channel state information., Comment: This paper is in the process of being submitted to IEEE Transactions on Wireless Communications

The rise of machine learning (ML) and its embedding in systems has drastically changed the engineering of software-intensive systems. Traditionally, software engineering focuses on manually created artifacts such as source code and the process of creating them, as well as best practices for integrating them, i.e., software architectures. In contrast, the development of ML artifacts, i.e. ML models, comes from data science and focuses on the ML models and their training data. However, to deliver value to end users, these ML models must be embedded in traditional software, often forming complex topologies. In fact, ML-enabled software can easily incorporate many different ML models. While the challenges and practices of building ML-enabled systems have been studied to some extent, beyond isolated examples, little is known about the characteristics of real-world ML-enabled systems. Properly embedding ML models in systems so that they can be easily maintained or reused is far from trivial. We need to improve our empirical understanding of such systems, which we address by presenting the first large-scale study of real ML-enabled software systems, covering over 2,928 open source systems on GitHub. We classified and analyzed them to determine their characteristics, as well as their practices for reusing ML models and related code, and the architecture of these systems. Our findings provide practitioners and researchers with insight into practices for embedding and integrating ML models, bringing data science and software engineering closer together.

Effective routing in satellite mega-constellations has become crucial to facilitate the handling of increasing traffic loads, more complex network architectures, as well as the integration into 6G networks. To enhance adaptability as well as robustness to unpredictable traffic demands, and to solve dynamic routing environments efficiently, machine learning-based solutions are being considered. For network control problems, such as optimizing packet forwarding decisions according to Quality of Service requirements and maintaining network stability, deep reinforcement learning techniques have demonstrated promising results. For this reason, we investigate the viability of multi-agent deep Q-networks for routing in satellite constellation networks. We focus specifically on reward shaping and quantifying training convergence for joint optimization of latency and load balancing in static and dynamic scenarios. To address identified drawbacks, we propose a novel hybrid solution based on centralized learning and decentralized control., Comment: 5 pages, 5 figures, to be published in proceedings of European Space Agency SPAICE Conference 2024, https://spaice.esa.int/

The fifth-generation new radio (5G NR) technology is expected to provide precise and reliable positioning capabilities along with high data rates. The Third Generation Partnership Project (3GPP) has started introducing positioning techniques from Release-16 based on time, angle, and signal strength using reference signals. However, validating these techniques with experimental prototypes is crucial before successful real-world deployment. This work provides useful tools and implementation details that are required in performing 5G positioning experiments with OpenAirInterface (OAI). As an example use case, we present an round trip time (RTT) estimation test-bed based on OAI and discusses the real-word experiment and measurement process.

Networks of ground stations designed to transmit and receive at optical wavelengths through the atmosphere offer an opportunity to provide on-demand, high-bandwidth, secure communications with spacecraft in Earth orbit and beyond. This work describes the operation and activities of current Free Space Optical Communication (FSOC) ground stations in Germany and Australasia. In Germany, FSOC facilities are located at the Oberpfaffenhofen campus of the Deutsches Zentrum fur Luft- und Raumfahrt (German Aerospace Center, DLR), the Laser-Bodenstation in Trauen (Responsive Space Cluster Competence Center, DLR), and the Research Center Space of the University of the Bundeswehr Munich in Neubiberg. The DLR also operates a ground station in Almeria, Spain as part of the European Optical Nucleus Network. The Australasian Optical Ground Station Network (AOGSN) is a proposed network of 0.5 -- 0.7m class optical telescopes located across Australia and New Zealand. The development and progress for each node of the AOGSN is reported, along with optimisation of future site locations based on cloud cover analysis., Comment: 17 pages, 12 Figures, Submitted to International Journal of Satellite Communications and Networking, Special Issue on Optical Space Communications

The fifth generation new radio (5G NR) technology is expected to fulfill reliable and accurate positioning requirements of industry use cases, such as autonomous robots, connected vehicles, and future factories. Starting from Third Generation Partnership Project (3GPP) Release-16, several enhanced positioning solutions are featured in the 5G standards, including the multi-cell round trip time (multi-RTT) method. This work presents a novel framework to estimate the round-trip time (RTT) between a user equipment (UE) and a base station (gNB) in 5G NR. Unlike the existing scheme in the standards, RTT can be estimated without the need to send timing measurements from both the gNB and UE to a central node. The proposed method relies on obtaining multiple coherent uplink wide-band channel measurements at the gNB by circumventing the timing advance control loops and the clock drift. The performance is evaluated through experiments leveraging a real world 5G testbed based on OpenAirInterface (OAI). Under a moderate system bandwidth of 40MHz, the experimental results show meter level range accuracy even in low signal-to-noise ratio (SNR) conditions.

This paper presents low-complexity block-based encoding and decoding algorithms for short block length channels. In terms of the precise use-case, we are primarily concerned with the baseline 3GPP Short block transmissions in which payloads are encoded by Reed-Muller codes and paired with orthogonal DMRS. In contemporary communication systems, the short block decoding often employs the utilization of DMRS-based least squares channel estimation, followed by maximum likelihood decoding. However, this methodology can incur substantial computational complexity when processing long bit length codes. We propose an innovative approach to tackle this challenge by introducing the principle of block/segment encoding using First-Order RM Codes which is amenable to low-cost decoding through block-based fast Hadamard transforms. The Block-based FHT has demonstrated to be cost-efficient with regards to decoding time, as it evolves from quadric to quasi-linear complexity with a manageable decline in performance. Additionally, by incorporating an adaptive DMRS/data power adjustment technique, we can bridge/reduce the performance gap and attain high sensitivity, leading to a good trade-off between performance and complexity to efficiently handle small payloads., Comment: Paper accepted and presented at the 16th IEEE AFRICON 2023, Nairobi, Kenya, Sept 20 to 22, 2023. arXiv admin note: substantial text overlap with arXiv:2404.10065

This paper presents a comprehensive analysis and performance enhancement of short block length channel detection incorporating training information. The current communication systems' short block length channel detection typically consists of least squares channel estimation followed by quasi-coherent detection. By investigating the receiver structure, specifically the estimator-correlator, we show that the non-coherent term, often disregarded in conventional detection metrics, results in significant losses in performance and sensitivity in typical operating regimes of 5G and 6G systems. A comparison with the fully non-coherent receiver in multi-antenna configurations reveals substantial losses in low spectral efficiency operating areas. Additionally, we demonstrate that by employing an adaptive DMRS-data power adjustment, it is possible to reduce the performance loss gap, which is amenable to a more sensitive quasi-coherent receiver. However, both of the aforementioned ML detection strategies can result in substantial computational complexity when processing long bit-length codes. We propose an approach to tackle this challenge by introducing the principle of block or segment coding using First-Order RM Codes, which is amenable to low-cost decoding through block-based fast Hadamard transforms. The Block-based FHT has demonstrated to be cost-efficient with regards to decoding time, as it evolves from quadric to quasi-linear complexity with a manageable decline in performance. Additionally, by incorporating an adaptive DMRS-data power adjustment technique, we are able to bridge/reduce the performance gap with respect to the conventional maximum likelihood receiver and attain high sensitivity, leading to a good trade-off between performance and complexity to efficiently handle small payloads., Comment: Paper accepted and presented at the 34th IEEE International Symposium on Personal, Indoor and Mobile Radio Communications(PIMRC 2023 ), Toronto, ON, Canada, Sept 5 to 8, 2023

This paper presents Bit-Interleaved Coded Modulation metrics for joint estimation detection using training or reference signal transmission strategies for short to long block length channels. We show that it is possible to enhance the performance and sensitivity through joint detection-estimation compared to standard receivers, especially when the channel state information is unknown and the density of the training dimensions is low. The performance analysis makes use of a full 5G transmitter and receiver chains for both Polar and LDPC coded transmissions paired with BPSK/QPSK modulation schemes. We consider transmissions where reference signals are interleaved with data and both are transmitted over a small number of OFDM symbols so that near-perfect channel estimation cannot be achieved. This is particularly adapted to mini-slot transmissions for ultra-reliable, low-latency communications (URLLC) or for short packet random access use cases. We characterize the performance for up to eight receiving antennas in order to determine the performance gain offered by the proposed BICM detection in realistic base station receiver scenarios. Our findings demonstrate that when the detection windows used in the metric units is on the order of four modulated symbols the proposed BICM metrics can be used to achieve detection performance that is close to that of a coherent receiver with perfect channel state information for both polar and LDPC coded configurations. Furthermore, we show that for transmissions with low DMRS density, a good trade-off can be achieved in terms of additional coding gain and improved channel estimation quality by adaptive DMRS power adjustment., Comment: Paper accepted and presented at the 2023 IEEE Conference on Standards for Communications and Networking (CSCN), Munich, Germany, November 2023

Object-Centric Event Logs (OCELs) form the basis for Object-Centric Process Mining (OCPM). OCEL 1.0 was first released in 2020 and triggered the development of a range of OCPM techniques. OCEL 2.0 forms the new, more expressive standard, allowing for more extensive process analyses while remaining in an easily exchangeable format. In contrast to the first OCEL standard, it can depict changes in objects, provide information on object relationships, and qualify these relationships to other objects or specific events. Compared to XES, it is more expressive, less complicated, and better readable. OCEL 2.0 offers three exchange formats: a relational database (SQLite), XML, and JSON format. This OCEL 2.0 specification document provides an introduction to the standard, its metamodel, and its exchange formats, aimed at practitioners and researchers alike.

Magnetic particle imaging is a tracer-based tomographic imaging technique that allows the concentration of magnetic nanoparticles to be determined with high spatio-temporal resolution. To reconstruct an image of the tracer concentration, the magnetization dynamics of the particles must be accurately modeled. A popular ensemble model is based on solving the Fokker-Plank equation, taking into account either Brownian or N\'eel dynamics. The disadvantage of this model is that it is computationally expensive due to an underlying stiff differential equation. A simplified model is the equilibrium model, which can be evaluated directly but in most relevant cases it suffers from a non-negligible modeling error. In the present work, we investigate an extended version of the equilibrium model that can account for particle anisotropy. We show that this model can be expressed as a series of Bessel functions, which can be truncated based on a predefined accuracy, leading to very short computation times, which are about three orders of magnitude lower than equivalent Fokker-Planck computation times. We investigate the accuracy of the model for 2D Lissajous magnetic particle imaging sequences and show that the difference between the Fokker-Planck and the equilibrium model with anisotropy is sufficiently small so that the latter model can be used for image reconstruction on experimental data with only marginal loss of image quality, even compared to a system matrix-based reconstruction., Comment: This work has been submitted to the IEEE for possible publication

Objective. The availability of magnetic nanoparticles with medical approval for human intervention is fundamental to the clinical translation of magnetic particle imaging (MPI). In this work, we thoroughly evaluate and compare the magnetic properties of an magnetic resonance imaging (MRI) approved tracer to validate its performance for MPI in future human trials. Approach. We analyze whether the recently approved MRI tracer Resotran is suitable for MPI. In addition, we compare Resotran with the previously approved and extensively studied tracer Resovist, with Ferrotran, which is currently in a clinical phase III study, and with the tailored MPI tracer Perimag. Main results. Initial magnetic particle spectroscopy measurements indicate that Resotran exhibits performance characteristics akin to Resovist, but below Perimag. We provide data on four different tracers using dynamic light scattering, transmission electron microscopy, vibrating sample magnetometry measurements, magnetic particle spectroscopy to derive hysteresis, point spread functions, and a serial dilution, as well as system matrix based MPI measurements on a preclinical scanner (Bruker 25/20 FF), including reconstructed images. Significance. Numerous approved magnetic nanoparticles used as tracers in MRI lack the necessary magnetic properties essential for robust signal generation in MPI. The process of obtaining medical approval for dedicated MPI tracers optimized for signal performance is an arduous and costly endeavor, often only justifiable for companies with a well-defined clinical business case. Resotran is an approved tracer that has become available in Europe for MRI. In this work, we study the eligibility of Resotran for MPI in an effort to pave the way for human MPI trials.

In modular educational systems, students are allowed to choose a part of their own curriculum themselves. This is typically done in the final class levels which lead to maturity for university access. The rationale behind letting students choose their courses themselves is to enhance self-responsibility, improve student motivation, and allow a focus on specific areas of interest. A central instrument for bringing these systems to fruition is the timetable. However, scheduling the timetable in such systems can be an extremely challenging and time-consuming task. In this study, we present a framework for classifying modular educational systems in Europe that reflects different degrees of freedom regarding student choices, and explore the consequences from the perspective of scheduling a timetable that satisfies all requirements from the organizational and the pedagogical perspective. For this purpose, we conducted interviews in Austria, Germany, Finland, Switzerland, the Netherlands, and Luxembourg and apply the framework to these educational systems, finding that among them the Finnish system shows the highest degree of modularity. After analyzing the consequences of modularity from the scheduling perspective, we assess the necessity for automated scheduling methods, which are central for realizing the potential and many benefits of modular education in practice., Comment: Preprint submitted to International Journal of Educational Research

In Magnetic Particle Imaging, a field-free region is maneuvered throughout the field of view using a time-varying magnetic field known as the drive-field. Human-sized systems operate the drive-field in the kHz range and generate it by utilizing strong currents that can rise to the kA range within a coil called the drive field generator. Matching and tuning between a power amplifier, a band-pass filter and the drive-field generator is required. Here, for reasons of safety in future human scanners, a symmetrical topology and a transformer, called inductive coupling network is used. Our primary objectives are to achieve floating potentials to ensure patient safety, attaining high linearity and high gain for the resonant transformer. We present a novel systematic approach to the design of a loss-optimized resonant toroid with a D-shaped cross section, employing segmentation to adjust the inductance-to-resistance ratio while maintaining a constant quality factor. Simultaneously, we derive a specific matching condition of a symmetric transmit-receive circuit for magnetic particle imaging. The chosen setup filters the fundamental frequency and allows simultaneous signal transmission and reception. In addition, the decoupling of multiple drive field channels is discussed and the primary side of the transformer is evaluated for maximum coupling and minimum stray field. Two prototypes were constructed, measured, decoupled, and compared to the derived theory and to method-of-moment based simulations.

Innovation and standardization in 5G have brought advancements to every facet of the cellular architecture. This ranges from the introduction of new frequency bands and signaling technologies for the radio access network (RAN), to a core network underpinned by micro-services and network function virtualization (NFV). However, like any emerging technology, the pace of real-world deployments does not instantly match the pace of innovation. To address this discrepancy, one of the key aspects under continuous development is the RAN with the aim of making it more open, adaptive, functional, and easy to manage. In this paper, we highlight the transformative potential of embracing novel cellular architectures by transitioning from conventional systems to the progressive principles of Open RAN. This promises to make 6G networks more agile, cost-effective, energy-efficient, and resilient. It opens up a plethora of novel use cases, ranging from ubiquitous support for autonomous devices to cost-effective expansions in regions previously underserved. The principles of Open RAN encompass: (i) a disaggregated architecture with modular and standardized interfaces; (ii) cloudification, programmability and orchestration; and (iii) AI-enabled data-centric closed-loop control and automation. We first discuss the transformative role Open RAN principles have played in the 5G era. Then, we adopt a system-level approach and describe how these Open RAN principles will support 6G RAN and architecture innovation. We qualitatively discuss potential performance gains that Open RAN principles yield for specific 6G use cases. For each principle, we outline the steps that research, development and standardization communities ought to take to make Open RAN principles central to next-generation cellular network designs., Comment: This paper is part of the IEEE JSAC SI on Open RAN. Please cite as: M. Polese, M. Dohler, F. Dressler, M. Erol-Kantarci, R. Jana, R. Knopp, T. Melodia, "Empowering the 6G Cellular Architecture with Open RAN," in IEEE Journal on Selected Areas in Communications, doi: 10.1109/JSAC.2023.3334610

Label-free approaches are attractive in cytological imaging due to their flexibility and cost efficiency. They are supported by machine learning methods, which, despite the lack of labeling and the associated lower contrast, can classify cells with high accuracy where the human observer has little chance to discriminate cells. In order to better integrate these workflows into the clinical decision making process, this work investigates the calibration of confidence estimation for the automated classification of leukocytes. In addition, different visual explanation approaches are compared, which should bring machine decision making closer to professional healthcare applications. Furthermore, we were able to identify general detection patterns in neural networks and demonstrate the utility of the presented approaches in different scenarios of blood cell analysis., Comment: Presented at the 3rd Workshop on Interpretable Machine Learning in Healthcare (IMLH) @ ICML 2023

This article provides an overview of the Low-Power Wake-Up Signal (LP-WUS) design in 3GPP Rel-18. A particular focus is the analysis of the different proposed low-power waveform designs in the Rel-18 study item including coding and modulation. The performance of the waveforms is compared through numerical simulations under various channel conditions. Furthermore, a novel coding scheme is proposed that exploits the WUS repetitions in time-domain to transmit additional payload and significantly increases spectral efficiency., Comment: Accepted for publication in IEEE CSCN 2023

Since the initial patent in 2001, the Magnetic Particle Imaging (MPI) community has been striving to develop an MPI scanner suitable for human applications. Numerous contributions from different research fields, regarding tracer development, reconstruction methods, hardware engineering, and sequence design have been employed in pursuit of this objective. In this work, we introduce and thoroughly characterize an improved head-sized MPI scanner with an emphasis on human safety. The scanner is operated by open-source software that enables scanning, monitoring, analysis, and reconstruction, designed to be handled by end users. Our primary focus is to present all technical components of the scanner, with the ultimate objective to investigate brain perfusion imaging in phantom experiments. We have successfully achieved full 3D single- and multi-contrast imaging capabilities at a frame rate of 4 Hz with sufficient sensitivity and resolution for brain applications. To assess system characterization, we devised sensitivity, resolution, perfusion, and multi-contrast experiments, as well as field measurements and sequence analysis. The acquired images were captured using a clinically approved tracer and suitable magnetic field strengths, while adhering to the established human peripheral nerve stimulation thresholds. This advanced scanner holds potential as a tomographic imager for diagnosing conditions such as ischemic stroke or intracranial hemorrhage in environments lacking electromagnetic shielding. Furthermore, due to its low power consumption it may have the potential to facilitate long-term monitoring within intensive care units for various applications., Comment: 22 pages, 9 figures

The evolution of charge carriers in photoexcited room temperature ZnO nanoparticles in solution is investigated using ultrafast ultraviolet photoluminescence spectroscopy, ultrafast Zn K-edge absorption spectroscopy and ab-initio molecular dynamics (MD) simulations. The photoluminescence is excited at 4.66 eV, well above the band edge, and shows that electron cooling in the conduction band and exciton formation occur in <500 fs, in excellent agreement with theoretical predictions. The X-ray absorption measurements, obtained upon excitation close to the band edge at 3.49 eV, are sensitive to the migration and trapping of holes. They reveal that the 2 ps transient largely reproduces the previously reported transient obtained at 100 ps time delay in synchrotron studies. In addition, the X-ray absorption signal is found to rise in ~1.4 ps, which we attribute to the diffusion of holes through the lattice prior to their trapping at singly-charged oxygen vacancies. Indeed, the MD simulations show that impulsive trapping of holes induces an ultrafast expansion of the cage of Zn atoms in <200 fs, followed by an oscillatory response at a frequency of ~100 cm-1, which corresponds to a phonon mode of the system involving the Zn sub-lattice.

Various imaging modalities allow for time-dependent image reconstructions from measurements where its acquisition also has a time-dependent nature. Magnetic particle imaging (MPI) falls into this class of imaging modalities and it thus also provides a dynamic inverse problem. Without proper consideration of the dynamic behavior, motion artifacts in the reconstruction become an issue. More sophisticated methods need to be developed and applied to the reconstruction of the time-dependent sequences of images. In this context, we investigate the incorporation of motion priors in terms of certain flow-parameter-dependent PDEs in the reconstruction process of time-dependent 3D images in magnetic particle imaging. The present work comprises the method development for a general 3D+time setting for time-dependent linear forward operators, analytical investigation of necessary properties in the MPI forward operator, modeling aspects in dynamic MPI, and extensive numerical experiments on 3D+time imaging including simulated data as well as measurements from a rotation phantom and in-vivo data from a mouse.

In this work, we propose an UAV-aided Integrated Access and Backhaul (IAB) system design offering 5G connectivity to ground users. UAV is integrated with a distributed unit (DU) acting as an aerial DU, which can provide 5G wireless backhaul access to a terrestrial central unit (CU). The CU-DU interface fully complies with the 3GPP defined F1 application protocol (F1AP). Such aerial DU can be instantiated and configured dynamically, tailoring to the network demands. The complete radio and access network solution is based on open-source software from OpenAirInterface (OAI) and off-the-shelf commercial 5G mobile terminals. Experimental results illustrate throughput gains and coverage extension brought by the aerial DU.

Due to the strong dependency of our societies onGlobal Navigation Satellite Systems and their vulnerability to outages, there is an urgent need for additional navigation systems. A possible approach for such an additional system uses the communication signals of the emerging LEO satellite mega-constellations as signals of opportunity. The Doppler shift of those signals is leveraged to calculate positioning, navigation and timing information. Therefore the signals have to be detected and the frequency has to be estimated. In this paper, we present the results of Starlink signal measurements. The results are used to develope a novel correlation-based detection algorithm for Starlink burst signals. The carrier frequency of the detected bursts is measured and the attainable positioning accuracy is estimated. It is shown, that the presented algorithms are applicable for a navigation solution in an operationally relevant setup using an omnidirectional antenna.

Objective. Magnetic Particle Imaging (MPI) is capable of high temporal resolution measurements of the spatial distribution of magnetic nanoparticles and therefore well suited for perfusion imaging, which is an important tool in medical diagnosis. Perfusion imaging in MPI usually requires a fresh bolus of tracer material to capture the key signal dynamics. Here, we propose a method to decouple the imaging sequence from the injection of additional tracer material, without further increasing the administered iron dose in the body with each image. Approach. A bolus of physiological saline solution without any particles (negative contrast) diminishes the steady-state concentration of a long-circulating tracer during passage. This depression in the measured concentration contributes to the required contrast dynamics. The presence of a long-circulating tracer is therefore a prerequisite to obtain the negative contrast. As a quantitative tracer based imaging method, the signal is linear in the tracer concentration for any location that contains nanoparticles and zero in the surrounding tissue which does not provide any intrinsic signal. After tracer injection, the concentration over time (positive contrast) can be utilized to calculate dynamic diagnostic parameters like perfusion parameters in vessels and organs. Every acquired perfusion image thus requires a new bolus of tracer with a sufficiently large iron dose to be visible above the background. Main results. Perfusion parameters are calculated based on the time response of the proposed negative bolus and compared to a positive bolus. Results from phantom experiments show that normalized signals from positive and negative boli are concurrent and deviations of calculated perfusion maps are low. Significance. Our method opens up the possibility to increase the total monitoring time, while minimizing the iron dose per acquired image., Comment: 19 pages, 6 figures

Precise knowledge of magnetic fields is crucial in many medical imaging applications like magnetic resonance imaging or magnetic particle imaging (MPI) as they are the foundation of these imaging systems. For the investigation of the influence of field imperfections on imaging, a compact and unique representation of the magnetic fields using real solid spherical harmonics, which can be obtained by measuring a few points of the magnetic field only, is of great assistance. In this manuscript, we review real solid harmonic expansions as a general solution of Laplace's equation including an efficient calculation of their coefficients using spherical t-designs. We also provide a method to shift the reference point of an expansion by calculating the coefficients of the shifted expansion from the initial ones. These methods are used to obtain the magnetic fields of an MPI system. Here, the field-free-point of the spatial encoding field serves as unique expansion point. Lastly, we quantify the severity of the distortions of the static and dynamic fields in MPI by analyzing the expansion coefficients., Comment: 25 pages

Machine learning techniques that perform morphological classification of astronomical sources often suffer from a scarcity of labelled training data. Here, we focus on the case of supervised deep learning models for the morphological classification of radio galaxies, which is particularly topical for the forthcoming large radio surveys. We demonstrate the use of generative models, specifically Wasserstein GANs (wGANs), to generate data for different classes of radio galaxies. Further, we study the impact of augmenting the training data with images from our wGAN on three different classification architectures. We find that this technique makes it possible to improve models for the morphological classification of radio galaxies. A simple Fully Connected Neural Network (FCN) benefits most from including generated images into the training set, with a considerable improvement of its classification accuracy. In addition, we find it is more difficult to improve complex classifiers. The classification performance of a Convolutional Neural Network (CNN) can be improved slightly. However, this is not the case for a Vision Transformer (ViT)., Comment: 15 pages, 7+6 figures, 1+5 tables; v2: matches published version in RASTI