36 results on '"Knipe, Jay O."'
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2. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
3. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
4. Nonclinical Pharmacokinetics of BMS-292655, a Water-Soluble Prodrug of the Antifungal Ravuconazole
5. Alicyclic Isoxazolinone Antibacterial Agents
6. The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease
7. Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase
8. Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus
9. Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor
10. Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies
11. HCV NS5A replication complex inhibitors. Part 5: Discovery of potent and pan-genotypic glycinamide cap derivatives
12. Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing
13. HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides
14. Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase
15. The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
16. Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
17. Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir
18. Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons
19. An Automated Liquid Chromatography-Mass Spectrometry Process to Determine Metabolic Stability Half-Life and Intrinsic Clearance of Drug Candidates by Substrate Depletion
20. Biaryl isoxazolinone antibacterial agents
21. N-{2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl}acetamide: An Orally Bioavailable Melatonin Receptor Agonist.
22. N-{2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl}acetamide: an orally bioavailable melatonin receptor agonist
23. Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates: Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity
24. Hepatitis C Virus NS5A ReplicationComplex Inhibitors.Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotypewith Inhibitory Activity Toward Genotypes 1a and 1b Replicons.
25. Cathepsin B-sensitive dipeptide prodrugs. 2. Models of anticancer drugs paclitaxel (Taxol®), mitomycin C and doxorubicin
26. Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications
27. Novel, water-soluble phosphate derivatives of 2′-ethoxy carbonylpaclitaxel as potential prodrugs of paclitaxel: Synthesis and antitumor evaluation
28. Synthesis of etoposide phosphate, BMY-40481: A water-soluble clinically active prodrug of etoposide
29. Novel water soluble phosphate prodrugs of taxol® possessing in vivo antitumor activity
30. Synthesis and antitumor evaluation of water soluble taxol phosphates
31. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.
32. .alpha.-Deuterium isotope effects and transition-state structure in an intramolecular model system for methyl-transfer enzymes
33. Methylase models: studies on general-base vs. nucleophilic catalysis in the intramolecular alkylation of phenols
34. Role of buffers in a methylase model reaction. General base catalysis by oxyanions vs. nucleophilic dealkylation by amines
35. Retention behavior of pteroyl-oligo-γ-l-glutamates in reversed-phase chromatography
36. Oxidation of pteridine derivatives in mice
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