Search

Your search keyword '"Knauf, Felix"' showing total 241 results
Start Over Author "Knauf, Felix"
241 results on '"Knauf, Felix"'

5. Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury

Author

Sieckmann, Tobias, Schley, Gunnar, Ögel, Neslihan, Kelterborn, Simon, Boivin, Felix J., Fähling, Michael, Ashraf, Muhammad I., Reichel, Martin, Vigolo, Emilia, Hartner, Andrea, Lichtenberger, Falk-Bach, Breiderhoff, Tilman, Knauf, Felix, Rosenberger, Christian, Aigner, Felix, Schmidt-Ott, Kai, Scholz, Holger, and Kirschner, Karin M.

Published
2023
Full Text
View/download PDF

6. End Point Considerations for Clinical Trials in Enteric Hyperoxaluria

Author

Langman, Craig B., Assimos, Dean, Blank, Melanie, Calle, Juan, Grauer, Andreas, Kausz, Annamaria, Milliner, Dawn, Nazzal, Lama, Smith, Kimberly, Tasian, Greg, Thompson, Aliza, Wood, Kyle D., Worcester, Elaine, Yang, Sixun, Malley, Meaghan A., Knauf, Felix, Lieske, John C., Assimos, Dean, Calle, Juan, Cowley, Helena, Dahl, Naomi, Grauer, Andreas, Hollander, Kim, Langman, Craig, Lieske, John, McClean, Lacy, Milliner, Dawn, Nazzal, Lama, Puurunen, Marja, Wheeler, Alistair, Wood, Kyle, Yocum, Richard, and Zeid, Joumana

Published
2023
Full Text
View/download PDF

10. SLC26A1 is a major determinant of sulfate homeostasis in humans

Author

Pfau, Anja, Lopez-Cayuqueo, Karen I., Scherer, Nora, Wuttke, Matthias, Wernstedt, Annekatrin, Fassrainer, Daniela Gonzalez, Smith, Desiree E.C., van de Kamp, Jiddeke M., Ziegeler, Katharina, Eckardt, Kai-Uwe, Luft, Friedrich C., Aronson, Peter S., Kottgen, Anna, Jentsch, Thomas J., and Knauf, Felix

Subjects
Metabolic regulation -- Genetic aspects -- Health aspects, Homeostasis -- Research -- Genetic aspects -- Health aspects, Carrier proteins -- Physiological aspects -- Health aspects -- Genetic aspects, Sulfates -- Physiological aspects -- Health aspects, Health care industry
Abstract

Sulfate plays a pivotal role in numerous physiological processes in the human body, including bone and cartilage health. A role of the anion transporter SLC26A1 (Sat1) for sulfate reabsorption in the kidney is supported by the observation of hyposulfatemia and hypersulfaturia in Slc26a1-knockout mice. The impact of SLC26A1 on sulfate homeostasis in humans remains to be defined. By combining clinical genetics, functional expression assays, and population exome analysis, we identify SLC26A1 as a sulfate transporter in humans and experimentally validate several loss-of-function alleles. Whole-exome sequencing from a patient presenting with painful perichondritis, hyposulfatemia, and renal sulfate wasting revealed a homozygous mutation in SLC26A1, which has not been previously described to the best of our knowledge. Whole-exome data analysis of more than 5,000 individuals confirmed that rare, putatively damaging SCL26A1 variants were significantly associated with lower plasma sulfate at the population level. Functional expression assays confirmed a substantial reduction in sulfate transport for the SLC26A1 mutation of our patient, which we consider to be novel, as well as for the additional variants detected in the population study. In conclusion, combined evidence from 3 complementary approaches supports SLC26A1 activity as a major determinant of sulfate homeostasis in humans. In view of recent evidence linking sulfate homeostasis with back pain and intervertebral disc disorder, our study identifies SLC26A1 as a potential target for modulation of musculoskeletal health., Introduction Sulfate is involved in numerous metabolic processes in humans. However, it is not measured as part of routine clinical chemistry tests, and few specialized laboratories provide this service. Therefore, [...]

Published
2023
Full Text
View/download PDF

13. Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation

Author

Egli-Spichtig, Daniela, Imenez Silva, Pedro Henrique, Glaudemans, Bob, Gehring, Nicole, Bettoni, Carla, Zhang, Martin Y.H., Pastor-Arroyo, Eva M., Schönenberger, Désirée, Rajski, Michal, Hoogewijs, David, Knauf, Felix, Misselwitz, Benjamin, Frey-Wagner, Isabelle, Rogler, Gerhard, Ackermann, Daniel, Ponte, Belen, Pruijm, Menno, Leichtle, Alexander, Fiedler, Georg-Martin, Bochud, Murielle, Ballotta, Virginia, Hofmann, Sandra, Perwad, Farzana, Föller, Michael, Lang, Florian, Wenger, Roland H., Frew, Ian, and Wagner, Carsten A.

Published
2019
Full Text
View/download PDF

15. Challenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework

Author

Ingenhoff, Rebecca, primary, Robertson, Nicole, additional, Munana, Richard, additional, Bodnar, Benjamin E, additional, Weswa, Ivan, additional, Sekitoleko, Isaac, additional, Gaal, Julia, additional, Kirenga, Bruce J, additional, Kalyesubula, Robert, additional, Knauf, Felix, additional, and Siddharthan, Trishul, additional

Published
2023
Full Text
View/download PDF

17. A preliminary survey of practice patterns across several European kidney stone centers and a call for action in developing shared practice

Author

Ferraro, Pietro Manuel, Arrabal-Polo, Miguel Ángel, Capasso, Giovambattista, Croppi, Emanuele, Cupisti, Adamasco, Ernandez, Thomas, Fuster, Daniel G., Galan, Juan Antonio, Grases, Felix, Hoorn, Ewout J., Knauf, Felix, Letavernier, Emmanuel, Mohebbi, Nilufar, Moochhala, Shabbir, Petkova, Kremena, Pozdzik, Agnieszka, Sayer, John, Seitz, Christian, Strazzullo, Pasquale, Trinchieri, Alberto, Vezzoli, Giuseppe, Vitale, Corrado, Vogt, Liffert, Unwin, Robert J., Bonny, Olivier, and Gambaro, Giovanni

Published
2019
Full Text
View/download PDF

22. Sputum Microbiome and Chronic Obstructive Pulmonary Disease in a Rural Ugandan Cohort of Well-Controlled HIV Infection

Author

Kayongo, Alex, primary, Bartolomaeus, Theda Ulrike Patricia, additional, Birkner, Till, additional, Markó, Lajos, additional, Löber, Ulrike, additional, Kigozi, Edgar, additional, Atugonza, Carolyne, additional, Munana, Richard, additional, Mawanda, Denis, additional, Sekibira, Rogers, additional, Uwimaana, Esther, additional, Alupo, Patricia, additional, Kalyesubula, Robert, additional, Knauf, Felix, additional, Siddharthan, Trishul, additional, Bagaya, Bernard S., additional, Kateete, David P., additional, Joloba, Moses L., additional, Sewankambo, Nelson K., additional, Jjingo, Daudi, additional, Kirenga, Bruce, additional, Checkley, William, additional, and Forslund, Sofia K., additional

Published
2023
Full Text
View/download PDF

23. Challenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework

Author

Ingenhoff,Rebecca, Robertson,Nicole, Munana,Richard, Bodnar,Benjamin E, Weswa,Ivan, Sekitoleko,Isaac, Gaal,Julia, Kirenga,Bruce J, Kalyesubula,Robert, Knauf,Felix, Siddharthan,Trishul, Ingenhoff,Rebecca, Robertson,Nicole, Munana,Richard, Bodnar,Benjamin E, Weswa,Ivan, Sekitoleko,Isaac, Gaal,Julia, Kirenga,Bruce J, Kalyesubula,Robert, Knauf,Felix, and Siddharthan,Trishul

Abstract

Rebecca Ingenhoff,1,2 Nicole Robertson,3 Richard Munana,4,5 Benjamin E Bodnar,6 Ivan Weswa,5 Isaac Sekitoleko,7,8 Julia Gaal,1 Bruce J Kirenga,9 Robert Kalyesubula,5,10,11 Felix Knauf,1,11 Trishul Siddharthan12 1Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany; 2Charité Center for Global Health, Charité - Universitätsmedizin Berlin, Berlin, Germany; 3University of Kentucky College of Medicine, Lexington, KY, USA; 4School of Public Health, Makerere University College of Health Sciences, Makerere University, Kampala, Uganda; 5African Community Center for Social Sustainability, Nakaseke, Uganda; 6Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 7MRC/UVRI and LSHTM Uganda Research Unit, Kampala, Uganda; 8London School of Hygiene and Tropical Medicine, London, UK; 9Makerere University Lung Institute, Kampala, Uganda; 10Department of Physiology, Department of Internal Medicine, Makerere University College of Health Sciences, Kampala, Uganda; 11Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA; 12Department of Pulmonary, Critical Care and Sleep Medicine, University of Miami, Coral Gables, FL, USACorrespondence: Rebecca Ingenhoff, Email Rebecca.ingenhoff@charite.deBackground: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. The burden of COPD is expected to increase in low- and middle-income countries (LMICs). COPD screening and diagnostics tools are often inaccessible in rural settings of LMICs. To contribute to the growing body of evidence on the effectiveness of Community Health Worker (CHW) interventions, this study aims to understand the facilitators and barriers of implementing a CHW-led COPD screening and referral program in rural Uganda.Methods: This qualitative study was conducted from September to October 2022 to explore Community Members, CHWs, and Healthcare Providers (HCPs) perceptions on the

Published
2023

27. Additional file 1 of Principles for task shifting hypertension and diabetes screening and referral: a qualitative study exploring patient, community health worker and healthcare professional perceptions in rural Uganda

Author

Ingenhoff, Rebecca, Munana, Richard, Weswa, Ivan, Gaal, Julia, Sekitoleko, Isaac, Mutabazi, Hillary, Bodnar, Benjamin E., Rabin, Tracy L., Siddharthan, Trishul, Kalyesubula, Robert, Knauf, Felix, and Nalwadda, Christine K.

Abstract

Supplementary Material 1

Published
2023
Full Text
View/download PDF

29. Oxalate homeostasis

Author

Ermer, Theresa, primary, Nazzal, Lama, additional, Tio, Maria Clarissa, additional, Waikar, Sushrut, additional, Aronson, Peter S., additional, and Knauf, Felix, additional

Published
2022
Full Text
View/download PDF

31. An update on the role of the inflammasomes in the pathogenesis of kidney diseases

Author

Darisipudi, Murthy N. and Knauf, Felix

Subjects
Inflammation -- Research -- Risk factors -- Care and treatment, Kidney diseases -- Research -- Development and progression -- Care and treatment -- Complications and side effects, Health
Abstract

Innate immune response pathways play a critical role as the first line of defense. Initiation of an immune response requires sensors that can detect noxious stimuli within the cellular microenvironment. Inflammasomes are signaling platforms that are assembled in response to both microbe-specific and nonmicrobial antigens. Upon activation, proinflammatory cytokines are released to engage immune defenses and to trigger an inflammatory cell death referred to as pyroptosis. The aim of this review is to provide an overview of the current knowledge of the role of the inflammasomes in the pathogenesis of kidney diseases. As crystal deposition in the kidney is a frequent cause of acute kidney injury and chronic kidney disease in children, recent insights into mechanisms of inflammasome activation by renal crystals are highlighted. This may be of particular interest to pediatric patients and nephrologists in need of new therapeutic approaches. Lastly, current data findings that inflammasomes are not only of major importance in host defense but are also a key regulator of the intestinal microbiota and the progression of systemic diseases are reviewed., Author(s): Murthy N. Darisipudi[sup.1] , Felix Knauf[sup.1] [sup.2] Author Affiliations: (1) Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Schwabachanlage 12, 91054, Erlangen, Germany (2) Department of Internal Medicine, Yale [...]

Published
2016
Full Text
View/download PDF

36. Different Murine Models of Kidney Injury Reveal a Common Pattern of Dysregulation within the Polyamine System in Favour of its Catabolic Pathways

Author

Sieckmann, Tobias, primary, Ögel, Neslihan, additional, Kelterborn, Simon, additional, Boivin, Felix J., additional, Schley, Gunnar, additional, Fähling, Michael, additional, Ashraf, Muhammad imtiaz, additional, Reichel, Martin, additional, Vigolo, Emilia, additional, Hartner, Andrea, additional, Knauf, Felix, additional, Rosenberger, Christian, additional, Aigner, Felix, additional, Smidt‐Ott, Kai, additional, Scholz, Holger, additional, and Kirschner, Karin M., additional

Published
2022
Full Text
View/download PDF

37. Bioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis

Author

Liu, Tong, Dogan, Inci, Rothe, Michael, Reichardt, Jana, Knauf, Felix, Gollasch, Maik, Luft, Friedrich C., and Gollasch, Benjamin

Subjects
hemodialysis, exercise, Cardiovascular and Metabolic Diseases, erythrocytes, lipidomics, lipids (amino acids, peptides, and proteins), fatty acids, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, chronic kidney disease
Abstract

Long-chain fatty acids (LCFAs) serve as energy sources, components of cell membranes, and precursors for signaling molecules. Uremia alters LCFA metabolism so that the risk of cardiovascular events in chronic kidney disease (CKD) is increased. End-stage renal disease (ESRD) patients undergoing dialysis are particularly affected and their hemodialysis (HD) treatment could influence blood LCFA bioaccumulation and transformation. We investigated blood LCFA in HD patients and studied LCFA profiles in vivo by analyzing arterio-venous (A-V) LFCA differences in upper limbs. We collected arterial and venous blood samples from 12 ESRD patients, before and after HD, and analyzed total LCFA levels in red blood cells (RBCs) and plasma by LC-MS/MS tandem mass spectrometry. We observed that differences in arterial and venous LFCA contents within RBCs (RBC LCFA A-V differences) were affected by HD treatment. Numerous saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA) n-6 showed negative A-V differences, accumulated during peripheral tissue perfusion of the upper limbs, in RBCs before HD. HD reduced these differences. The omega-3 quotient in the erythrocyte membranes was not affected by HD in either arterial or venous blood. Our data demonstrate that A-V differences in fatty acids status of LCFA are present and active in mature erythrocytes and their bioaccumulation is sensitive to single HD treatment.

Published
2022
Full Text
View/download PDF

38. Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

Author

Birkenfeld, Andreas L., Lee, Hui-Young, Guebre-Egziabher, Fitsum, Alves, Tiago C., Jurczak, Michael J., Jornayvaz, Francois R., Zhang, Dongyang, Hsiao, Jennifer J., Martin-Montalvo, Alejandro, Fischer-Rosinsky, Antje, Spranger, Joachim, Pfeiffer, Andreas F., Jordan, Jens, Fromm, Martin F., König, Jörg, Lieske, Stefanie, Carmean, Christopher M., Frederick, David W., Weismann, Dirk, Knauf, Felix, Irusta, Pablo M., De Cabo, Rafael, Helfand, Stephen L., Samuel, Varman T., and Shulman, Gerald I.

Published
2011
Full Text
View/download PDF

43. High Oxalate Concentrations Correlate with Increased Risk for Sudden Cardiac Death in Dialysis Patients

Author

Pfau, Anja, primary, Ermer, Theresa, additional, Coca, Steven G., additional, Tio, Maria Clarissa, additional, Genser, Bernd, additional, Reichel, Martin, additional, Finkelstein, Fredric O., additional, März, Winfried, additional, Wanner, Christoph, additional, Waikar, Sushrut S., additional, Eckardt, Kai-Uwe, additional, Aronson, Peter S., additional, Drechsler, Christiane, additional, and Knauf, Felix, additional

Published
2021
Full Text
View/download PDF

46. Additional file 1 of The rural Uganda non-communicable disease (RUNCD) study: prevalence and risk factors of self-reported NCDs from a cross sectional survey

Author

Siddharthan, Trishul, Kalyesubula, Robert, Morgan, Brooks, Ermer, Theresa, Rabin, Tracy L., Kayongo, Alex, Munana, Richard, Anton, Nora, Kast, Katharina, Schaeffner, Elke, Kirenga, Bruce, and Knauf, Felix

Abstract

Additional file 1: Supplement Fig. 1. Prevalence of self-reported non-communicable diseases in Nakaseke stratified by sex and age. The prevalence of self-reported asthma, COPD, diabetes, kidney disease, hypertension, or multimorbidity by 15-year increments stratified by sex. (Designed by Helmut Kraus, permission obtained)

Published
2021
Full Text
View/download PDF

48. Additional file 3 of Acceptability of patient-centered hypertension education delivered by community health workers among people living with HIV/AIDS in rural Uganda

Author

Batte, Charles, Mukisa, John, Rykiel, Natalie, Mukunya, David, Checkley, William, Knauf, Felix, Kalyesubula, Robert, and Siddharthan, Trishul

Abstract

Additional file 3. COREQ: Consolidated criteria for reporting qualitative research: a 32-item checklist for interviews and focus groups.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results