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3. Left Atrial Function in Patients with Titin Cardiomyopathy

Author

HENKENS, MICHIEL T.H.M., RAAFS, ANNE G., VANLOON, TIM, VOS, JACQUELINE L., VANDENWIJNGAARD, ARTHUR, BRUNNER, HAN G., KRAPELS, INGRID P.C., KNACKSTEDT, CHRISTIAN, GERRETSEN, SUZANNE, HAZEBROEK, MARK R., VERNOOY, KEVIN, NIJVELDT, ROBIN, LUMENS, JOOST, and VERDONSCHOT, JOB A.J.

Published
2024
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8. Detection of cardiac amyloidosis on routine bone scintigraphy: an important gatekeeper role for the nuclear medicine physician

Author

Cardiologie, Team Medisch, Circulatory Health, Nebhwani, Mohit, Chaibekava, Karina, Achten, Anouk, Oerlemans, Marish I.F.J., Michels, Michelle, van der Meer, Peter, Nienhuis, Hans L.A., Weerts, Jerremy, van Empel, Vanessa, Rocca, Hans Peter Brunner La, Wijk, Sandra Sanders van, van der Pol, Jochem, Knackstedt, Christian, Cardiologie, Team Medisch, Circulatory Health, Nebhwani, Mohit, Chaibekava, Karina, Achten, Anouk, Oerlemans, Marish I.F.J., Michels, Michelle, van der Meer, Peter, Nienhuis, Hans L.A., Weerts, Jerremy, van Empel, Vanessa, Rocca, Hans Peter Brunner La, Wijk, Sandra Sanders van, van der Pol, Jochem, and Knackstedt, Christian

Published
2024

9. Evaluation of the 2021 ESC recommendations for family screening in hereditary transthyretin cardiac amyloidosis

Author

Muller, Steven A, Peiró-Aventin, Belén, Biagioni, Giulia, Tini, Giacomo, Saturi, Giulia, Kronberger, Christina, Achten, Anouk, Dobner, Stephan, Te Rijdt, Wouter P, Gasperetti, Alessio, Te Riele, Anneline S J M, Varrà, Guerino G, Ponziani, Alberto, Hirsch, Alexander, Porcari, Aldostefano, van der Meer, Manon G, Zampieri, Mattia, van der Harst, Pim, Kammerlander, Andreas, Biagini, Elena, van Tintelen, J Peter, Barbato, Emanuele, Asselbergs, Folkert W, Menale, Silvia, Gräni, Christoph, Merlo, Marco, Michels, Michelle, Knackstedt, Christian, Nitsche, Christian, Longhi, Simone, Musumeci, Beatrice, Cappelli, Francesco, Garcia-Pavia, Pablo, Oerlemans, Marish I F J, Muller, Steven A, Peiró-Aventin, Belén, Biagioni, Giulia, Tini, Giacomo, Saturi, Giulia, Kronberger, Christina, Achten, Anouk, Dobner, Stephan, Te Rijdt, Wouter P, Gasperetti, Alessio, Te Riele, Anneline S J M, Varrà, Guerino G, Ponziani, Alberto, Hirsch, Alexander, Porcari, Aldostefano, van der Meer, Manon G, Zampieri, Mattia, van der Harst, Pim, Kammerlander, Andreas, Biagini, Elena, van Tintelen, J Peter, Barbato, Emanuele, Asselbergs, Folkert W, Menale, Silvia, Gräni, Christoph, Merlo, Marco, Michels, Michelle, Knackstedt, Christian, Nitsche, Christian, Longhi, Simone, Musumeci, Beatrice, Cappelli, Francesco, Garcia-Pavia, Pablo, and Oerlemans, Marish I F J

Abstract

AIMS: The 2021 European Society of Cardiology (ESC) screening recommendations for individuals carrying a pathogenic transthyretin amyloidosis variant (ATTRv) are based on expert opinion. We aimed to (i) determine the penetrance of ATTRv cardiomyopathy (ATTRv-CM) at baseline; (ii) examine the value of serial evaluation; and (iii) establish the yield of first-line diagnostic tests (i.e. electrocardiogram, echocardiogram, and laboratory tests) as per 2021 ESC position statement.METHODS AND RESULTS: We included 159 relatives (median age 55.6 [43.2-65.9] years, 52% male) at risk for ATTRv-CM from 10 centres. The primary endpoint, ATTRv-CM diagnosis, was defined as the presence of (i) cardiac tracer uptake in bone scintigraphy; or (ii) transthyretin-positive cardiac biopsy. The secondary endpoint was a composite of heart failure (New York Heart Association class ≥II) and pacemaker-requiring conduction disorders. At baseline, 40/159 (25%) relatives were diagnosed with ATTRv-CM. Of those, 20 (50%) met the secondary endpoint. Indication to screen (≤10 years prior to predicted disease onset and absence of extracardiac amyloidosis) had an excellent negative predictive value (97%). Other pre-screening predictors for ATTRv-CM were infrequently identified variants and male sex. Importantly, 13% of relatives with ATTRv-CM did not show any signs of cardiac involvement on first-line diagnostic tests. The yield of serial evaluation (n = 41 relatives; follow-up 3.1 [2.2-5.2] years) at 3-year interval was 9.4%.CONCLUSIONS: Screening according to the 2021 ESC position statement performs well in daily clinical practice. Clinicians should adhere to repeating bone scintigraphy after 3 years, as progressing to ATTRv-CM without signs of ATTRv-CM on first-line diagnostic tests or symptoms is common.

Published
2024

10. Detection of cardiac amyloidosis on routine bone scintigraphy:an important gatekeeper role for the nuclear medicine physician

Author

Nebhwani, Mohit, Chaibekava, Karina, Achten, Anouk, Oerlemans, Marish I.F.J., Michels, Michelle, van der Meer, Peter, Nienhuis, Hans L.A., Weerts, Jerremy, van Empel, Vanessa, Rocca, Hans Peter Brunner La, Wijk, Sandra Sanders van, van der Pol, Jochem, Knackstedt, Christian, Nebhwani, Mohit, Chaibekava, Karina, Achten, Anouk, Oerlemans, Marish I.F.J., Michels, Michelle, van der Meer, Peter, Nienhuis, Hans L.A., Weerts, Jerremy, van Empel, Vanessa, Rocca, Hans Peter Brunner La, Wijk, Sandra Sanders van, van der Pol, Jochem, and Knackstedt, Christian

Abstract

Cardiac amyloidosis (CA)—mostly transthyretin-related (ATTR-CA)—has recently gained interest in cardiology. Bone scintigraphy (BS) is one of the main screening tools for ATTR-CA but also used for various other reasons. The objective was to evaluate whether all CA cases are detected and what happens during follow-up. All routine BS performed at the Maastricht University Medical Center (May 2012–August 2020) were screened for the presence of CA. Scans performed for suspected CA were excluded. A Perugini stage ≥1 was classified as positive necessitating further examination. The electronic medical record system was evaluated for any contact with cardiology or other specialists until 2021. Of the 2738 BS evaluated, 40 scans (1.46%; median age 73.5 [IQR: 65.8–79.5], 82.5% male) were positive (Perugini grade 1: 31/77.5%, grade 2: 6/15%, grade 3: 3/7.5%); the potential diagnosis ATTR-CA was not seen in 38 patients (95%) by the nuclear medicine specialist. During follow-up, 19 out of those 40 patients (47.5%) underwent cardiac evaluation without diagnosing CA. Available echocardiograms of patients with a positive BS showed left ventricular hypertrophy, a preserved ejection fraction, and diastolic dysfunction ≥2 in 9/47%, 10/53%, and 4/21% of patients, respectively. Additionally, 20 (50%) patients presented to at least one specialty with symptoms indicative of cardiac amyloidosis. The prevalence of a positive BS indicating potential CA in an unselected population is low but substantial. The majority was not detected which asks for better awareness for CA of all involved specialists to ensure appropriate treatment and follow-up. Graphical abstract: (Figure presented.)

Published
2024

11. Absence of an increased wall thickness does not rule out cardiac amyloidosis

Author

Team Onderzoek, Team Medisch, Arts Assistenten Cardiologie, Gezonde Vaten, Circulatory Health, Genetica Groep Van Tintelen, Cancer, Child Health, Muller, Steven A, Achten, Anouk, van der Meer, Manon G, Zwetsloot, Peter-Paul, Sanders-van Wijk, Sandra, van der Harst, Pim, van Tintelen, J Peter, Te Riele, Anneline S J M, van Empel, Vanessa, Knackstedt, Christian, Oerlemans, Marish I F J, Team Onderzoek, Team Medisch, Arts Assistenten Cardiologie, Gezonde Vaten, Circulatory Health, Genetica Groep Van Tintelen, Cancer, Child Health, Muller, Steven A, Achten, Anouk, van der Meer, Manon G, Zwetsloot, Peter-Paul, Sanders-van Wijk, Sandra, van der Harst, Pim, van Tintelen, J Peter, Te Riele, Anneline S J M, van Empel, Vanessa, Knackstedt, Christian, and Oerlemans, Marish I F J

Published
2024

12. Value of Speckle Tracking–Based Deformation Analysis in Screening Relatives of Patients With Asymptomatic Dilated Cardiomyopathy

Author

Verdonschot, Job A.J., Merken, Jort J., Brunner-La Rocca, Hans-Peter, Hazebroek, Mark R., Eurlings, Casper G.M.J., Thijssen, Eline, Wang, Ping, Weerts, Jerremy, van Empel, Vanessa, Schummers, Georg, Schreckenberg, Marcus, van den Wijngaard, Arthur, Lumens, Joost, Brunner, Han G., Heymans, Stephane R.B., Krapels, Ingrid P.C., and Knackstedt, Christian

Published
2020
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13. Cytotoxic T Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy.

Author

Sikking, Maurits A., Harding, Daniel, Henkens, Michiel T.H.M., Stroeks, Sophie L.V.M., Venner, Max F.G.H.M., Nihant, Bastien, van Leeuwen, Rick E.W., Fanti, Silvia, Li, Xiaofei, van Paassen, Pieter, Knackstedt, Christian, Brunner-la Rocca, Hans-Peter, van Empel, Vanessa P.M., Verdonschot, Job A.J., Marelli-Berg, Federica M., and Heymans, Stephane R.B.

Published
2024
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17. Cardiac Inflammation Impedes Response to Cardiac Resynchronization Therapy in Patients with Idiopathic Dilated Cardiomyopathy

Author

Verdonschot, Job A.J., Merken, Jort J., van Stipdonk, Antonius M.W., Pliger, Philipp, Derks, Kasper W.J., Wang, Ping, Henkens, Michiel T.H.M., van Paassen, Pieter, Abdul Hamid, Myrurgia A., van Empel, Vanessa P.M., Knackstedt, Christian, Luermans, Justin G.L.M., Crijns, Harry J.G.M., Rocca, Hans-Peter Brunner-La, Brunner, Han G., Poelzl, Gerhard, Vernooy, Kevin, Heymans, Stephane R.B., and Hazebroek, Mark R.

Published
2020
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18. Absence of an increased wall thickness does not rule out cardiac amyloidosis.

Author

Muller, Steven A., Achten, Anouk, van der Meer, Manon G., Zwetsloot, Peter-Paul, Sanders-van Wijk, Sandra, van der Harst, Pim, van Tintelen, J. Peter, te Riele, Anneline S. J. M., van Empel, Vanessa, Knackstedt, Christian, and Oerlemans, Marish I. F. J.

Subjects
SINGLE-photon emission computed tomography, CARDIAC magnetic resonance imaging, RADIONUCLIDE imaging, VENTRICULAR septum, CARDIAC amyloidosis, VENTRICULAR ejection fraction, HEART failure
Abstract

This document is a letter to the editor of the journal Amyloid. The authors discuss the diagnosis of transthyretin amyloid (ATTR) cardiomyopathy (ATTR-CM), a progressive and life-threatening heart condition. They question the current diagnostic criteria, which suggest that a wall thickness of ≥12 mm should be used to screen for cardiac amyloidosis. The authors conducted a study to determine the correlation between wall thickness measurements and tracer uptake in bone scintigraphy, as well as the prevalence of a wall thickness <12 mm in ATTR-CM patients. They found that a significant number of patients with ATTR-CM did not have an increased wall thickness, suggesting that a wall thickness <12 mm does not rule out cardiac amyloidosis. The authors recommend further research to determine if these patients benefit from treatment. [Extracted from the article]

Published
2024
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20. Webtool to enhance the accuracy of diagnostic algorithms for HFpEF: a prospective cross‐over study

Author

Weerts, Jerremy, primary, Amin, Hesam, additional, Barandiarán Aizpurua, Arantxa, additional, Gevaert, Andreas B., additional, Handoko, M. Louis, additional, Dauw, Jeroen, additional, Tun, Han Naung, additional, Rommel, Karl‐Philipp, additional, Verbrugge, Frederik H., additional, Kresoja, Karl‐Patrik, additional, Sanders‐van Wijk, Sandra, additional, Brunner‐La Rocca, Hans‐Peter, additional, Bayés‐Genís, Antoni, additional, Lumens, Joost, additional, Knackstedt, Christian, additional, and van Empel, Vanessa P.M., additional

Published
2023
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22. Biomarkers of Collagen Metabolism Are Associated with Left Ventricular Function and Prognosis in Dilated Cardiomyopathy: A Multi-Modal Study

Author

Raafs, Anne G., primary, Adriaans, Bouke P., additional, Henkens, Michiel T. H. M., additional, Verdonschot, Job A. J., additional, Abdul Hamid, Myrurgia A., additional, Díez, Javier, additional, Knackstedt, Christian, additional, van Empel, Vanessa P. M., additional, Brunner-La Rocca, Hans-Peter, additional, González, Arantxa, additional, Wildberger, Joachim E., additional, Heymans, Stephane R. B., additional, and Hazebroek, Mark R., additional

Published
2023
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23. Influence of Individual Personality Traits of the Reader on Visual Assessment of Left Ventricular Ejection Fraction: Another Reason to Abandon Visual Assessment

Author

Knackstedt, Christian, primary, Ramaekers, Bram, additional, Schummers, Georg, additional, Schreckenberg, Marcus, additional, Faessen, Jelle, additional, Marx, Nikolaus, additional, Becker, Michael, additional, Sanders-van Wijk, Sandra, additional, van Empel, Vanessa, additional, Norra, Christine, additional, Kunert, Hanns Jürgen, additional, Brunner-La Rocca, Hans-Peter, additional, Altiok, E., additional, Becker, M., additional, Bekkers, S.C.A.M., additional, Barandiaran, A., additional, Brandenburg, V.M., additional, Brunner-la Rocca, H.P., additional, Cheriex, E.C., additional, Dettori, R., additional, Dinh, N.H.T., additional, Driessen, R., additional, van Empel, V., additional, Ertmer, J., additional, Eurlings, C., additional, Geyik, Z., additional, Hamada, S., additional, Heymans, S.R.B., additional, Holvoet, W., additional, Ilhan, M., additional, Jaarsma, C., additional, Janssen, R., additional, Kästner, W., additional, Kersten, A., additional, Lencer, N.H.K.M., additional, Luermans, J., additional, Mischke, K., additional, Pisters, R., additional, Poels, E., additional, Pluimen, M., additional, Schalla, S.M., additional, Scheenstra, B., additional, Sanders- van Wijk, S., additional, Schöder, J.W., additional, Skobel, E., additional, Stipdonk, T., additional, Stöhr, R., additional, Streukens, S.A.F., additional, Strik, M., additional, Tchaikovsky, V., additional, Theunissen, R.A.L.J., additional, Ubachs, J., additional, Vainer, J., additional, Vernooy, K., additional, Weijs, B., additional, Winkler, P., additional, and van Workum, S., additional

Published
2023
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24. Liver stiffness as a cornerstone in heart disease risk assessment.

Author

Boeckmans, Joost, Sandrin, Laurent, Knackstedt, Christian, and Schattenberg, Jörn M.

Subjects
HEART diseases, HEART disease related mortality, CORONARY disease, ARRHYTHMIA, HEPATIC fibrosis, LIVER
Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) typically presents with hepatic fibrosis in advanced disease, resulting in increased liver stiffness. A subset of patients further develops liver cirrhosis and hepatocellular carcinoma. Cardiovascular disease is a common comorbidity in patients with MASLD and its prevalence is increasing in parallel. Recent evidence suggests that especially liver stiffness, whether or not existing against a background of MASLD, is associated with heart diseases. We conducted a narrative review on the role of liver stiffness in the prediction of highly prevalent heart diseases including heart failure, cardiac arrhythmias (in particular atrial fibrillation), coronary heart disease, and aortic valve sclerosis. Research papers were retrieved from major scientific databases (PubMed, Web of Science) until September 2023 using 'liver stiffness' and 'liver fibrosis' as keywords along with the latter cardiac conditions. Increased liver stiffness, determined by vibration-controlled transient elastography or hepatic fibrosis as predicted by biomarker panels, are associated with a variety of cardiovascular diseases, including heart failure, atrial fibrillation, and coronary heart disease. Elevated liver stiffness in patients with metabolic liver disease should lead to considerations of cardiac workup including N-terminal pro-- B-type natriuretic peptide/B-type natriuretic peptide determination, electrocardiography, and coronary computed tomography angiography. In addition, patients with MASLD would benefit from heart disease case-finding strategies in which liver stiffness measurements can play a key role. In conclusion, increased liver stiffness should be a trigger to consider a cardiac workup in metabolically compromised patients. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Prognostic value of signs and symptoms in heart failure patients using remote telemonitoring.

Author

Gingele, Arno Joachim, Brandts, Lloyd, Vossen, Kjeld, Knackstedt, Christian, Boyne, Josiane, and Brunner-La Rocca, Hans-Peter

Subjects
HEART failure, HEART failure patients, PROGNOSIS, SYMPTOMS, LOGISTIC regression analysis, CLINICAL deterioration
Abstract

Introduction: Heart failure is a serious burden on health care systems due to frequent hospital admissions. Early recognition of outpatients at risk for clinical deterioration could prevent hospitalization. Still, the role of signs and symptoms in monitoring heart failure patients is not clear. The heart failure coach is a web-based telemonitoring application consisting of a 9-item questionnaire assessment of heart failure signs and symptoms and developed to identify outpatients at risk for clinical deterioration. If deterioration was suspected, patients were contacted by a heart failure nurse for further evaluation. Methods: Heart failure coach questionnaires completed between 2015 and 2018 were collected from 287 patients, completing 18,176 questionnaires. Adverse events were defined as all-cause mortality, heart failure- or cardiac-related hospital admission or emergency cardiac care visits within 30 days after completion of each questionnaire. Multilevel logistic regression analyses were performed to assess the association between the heart failure coach questionnaire items and the odds of an adverse event. Results: No association between dyspnea and adverse events was observed (odds ratio 1.02, 95% confidence interval 0.79–1.30). Peripheral edema (odds ratio 2.21, 95% confidence interval 1.58–3.11), persistent chest pain (odds 2.06, 95% confidence interval 1.19–3.58), anxiety about heart failure (odds ratio 2.12, 95% confidence interval 1.44–3.13), and extensive struggle to perform daily activities (odds ratio 2.23, 95% confidence interval 1.38–3.62) were significantly associated with adverse outcome. Discussion: Regular assessment of more than the classical signs and symptoms may be helpful to identify heart failure patients at risk for clinical deterioration and should be an integrated part of heart failure telemonitoring programs. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Evaluating subclinical left ventricular and left atrial dysfunction in idiopathic atrial fibrillation:A speckle-tracking based strain-analysis

Author

van Mourik, Manouk J.W., Linz, Dominik, Verwijs, Harm J.A., Bekkers, Sebastiaan C.A.M., Weerts, Jerremy, Schotten, Ulrich, Rocca, Hanspeter Brunner La, Lumens, Joost, Crijns, Harry J.G.M., Weijs, Bob, Knackstedt, Christian, van Mourik, Manouk J.W., Linz, Dominik, Verwijs, Harm J.A., Bekkers, Sebastiaan C.A.M., Weerts, Jerremy, Schotten, Ulrich, Rocca, Hanspeter Brunner La, Lumens, Joost, Crijns, Harry J.G.M., Weijs, Bob, and Knackstedt, Christian

Abstract

Objective: A subset of patients with atrial fibrillation (AF) presents without established AF risk factors and normal left ventricular (LV) systolic function, called idiopathic AF (IAF). Traditionally, echocardiography derived LV dimensions and ejection fraction (EF) are used to exclude LV dysfunction in IAF, but their sensitivity is limited. Our objective is to evaluate the presence of subtle alterations in LV function despite normal LVEF in patients with IAF compared to healthy controls, using speckle-tracking echocardiography (STE) based global longitudinal strain (GLS). Methods: Standard transthoracic echocardiography was performed in 80 patients with IAF and 129 healthy controls. Patients with overt cardiac disease as well as known established AF risk factors were excluded. STE analysis was performed to assess GLS of the LV, and left atrial strain (LAS). Results: LVEF was normal and comparable between patients with IAF and healthy controls (63 ± 4% for both groups; p = 0.801). Mean GLS was within normal limits for both groups but statistically significantly more negative in patients with IAF (−20.6 ± 2.5% vs. -19.7 ± 2.5%; p = 0.016), however not when indexed for ventricular cycle length (p = 0.784). No differences in LA volume or non-indexed LAS were seen in patients with IAF compared to healthy controls. Conclusions: In this selected group of IAF patients, STE did not detect any overt LV or LA dysfunction compared to healthy controls. Thus, IAF occurred in these patients not only in the absence of established AF risk factors but also without evidence of ventricular or atrial dysfunction.

Published
2023

28. Cardiac Troponin T and I Release After a 30-km Run

Author

Klinkenberg, Lieke J.J., Luyten, Peter, van der Linden, Noreen, Urgel, Kim, Snijders, Daniëlle P.C., Knackstedt, Christian, Dennert, Robert, Kietselaer, Bastiaan L.J.H., Mingels, Alma M.A., Cardinaels, Eline P.M., Peeters, Frederique E.C.M., van Suijlen, Jeroen D.E., ten Kate, Joop, Marsch, Elke, Theelen, Thomas L., Sluimer, Judith C., Wouters, Kristiaan, Bekers, Otto, Bekkers, Sebastiaan C.A.M., van Loon, Luc J.C., van Dieijen-Visser, Marja P., and Meex, Steven J.R.

Published
2016
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29. Influence of Individual Personality Traits of the Reader on Visual Assessment of Left Ventricular Ejection Fraction: Another Reason to Abandon Visual Assessment

Author

Altiok, E., Becker, M., Bekkers, S.C.A.M., Barandiaran, A., Brandenburg, V.M., Brunner-la Rocca, H.P., Cheriex, E.C., Dettori, R., Dinh, N.H.T., Driessen, R., van Empel, V., Ertmer, J., Eurlings, C., Geyik, Z., Hamada, S., Heymans, S.R.B., Holvoet, W., Ilhan, M., Jaarsma, C., Janssen, R., Kästner, W., Kersten, A., Lencer, N.H.K.M., Luermans, J., Mischke, K., Pisters, R., Poels, E., Pluimen, M., Schalla, S.M., Scheenstra, B., Sanders-van Wijk, S., Schöder, J.W., Skobel, E., Stipdonk, T., Stöhr, R., Streukens, S.A.F., Strik, M., Tchaikovsky, V., Theunissen, R.A.L.J., Ubachs, J., Vainer, J., Vernooy, K., Weijs, B., Winkler, P., van Workum, S., Knackstedt, Christian, Ramaekers, Bram, Schummers, Georg, Schreckenberg, Marcus, Faessen, Jelle, Marx, Nikolaus, Becker, Michael, Sanders-van Wijk, Sandra, van Empel, Vanessa, Norra, Christine, Kunert, Hanns Jürgen, and Brunner-La Rocca, Hans-Peter

Published
2023
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30. Left Atrial Strain Is an Independent Predictor of New-Onset Atrial Fibrillation in Dilated Cardiomyopathy

Author

Raafs, Anne G., primary, Vos, Jacqueline L., additional, Henkens, Michiel T.H.M., additional, Verdonschot, Job A.J., additional, Sikking, Maurits, additional, Stroeks, Sophie, additional, Gerretsen, Suzanne, additional, Hazebroek, Mark R., additional, Knackstedt, Christian, additional, Nijveldt, Robin, additional, and Heymans, Stephane R.B., additional

Published
2023
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33. Myocardial Fibrosis Assessment Using T1 and ECV Mapping With Histologic Validation in Chronic Dilated Cardiomyopathy

Author

Raafs, Anne G., primary, Adriaans, Bouke P., additional, Henkens, Michiel T.H.M., additional, Verdonschot, Job A.J., additional, Ramaekers, Mitch J.F.G., additional, Gommers, Suzanne, additional, Abdul Hamid, Myrurgia A., additional, Schalla, Simon, additional, Knackstedt, Christian, additional, van Empel, Vanessa.P.M., additional, Brunner-la Rocca, Hans-Peter, additional, Wildberger, J.E., additional, Bekkers, Sebastiaan C.A.M., additional, and Hazebroek, Mark R., additional

Published
2022
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35. Dynamic Ejection Fraction Trajectory in Patients With Dilated Cardiomyopathy With a Truncating Titin Variant

Author

Henkens, Michiel T.H.M., primary, Stroeks, Sophie L.V.M., additional, Raafs, Anne G., additional, Sikking, Maurits A., additional, Tromp, Jasper, additional, Ouwerkerk, Wouter, additional, Hazebroek, Mark R., additional, Krapels, Ingrid P.C., additional, Knackstedt, Christian, additional, van den Wijngaard, Arthur, additional, Brunner, Han G., additional, Heymans, Stephane R.B., additional, and Verdonschot, Job A.J., additional

Published
2022
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36. Cardiovascular outcome 6 months after severe coronavirus disease 2019 infection

Author

Raafs, Anne G, Ghossein, Mohammed A, Brandt, Yentl, Henkens, Michiel T H M, Kooi, M Eline, Vernooy, Kevin, Spaanderman, Marc E A, Gerretsen, Suzanne, van Santen, Susanne, Driessen, Rob G H, Knackstedt, Christian, van der Horst, Iwan C C, van Bussel, Bas C T, Heymans, Stephane R B, Ghossein-Doha, Chahinda, MaastrICCht Collaborators, Raafs, Anne G, Ghossein, Mohammed A, Brandt, Yentl, Henkens, Michiel T H M, Kooi, M Eline, Vernooy, Kevin, Spaanderman, Marc E A, Gerretsen, Suzanne, van Santen, Susanne, Driessen, Rob G H, Knackstedt, Christian, van der Horst, Iwan C C, van Bussel, Bas C T, Heymans, Stephane R B, Ghossein-Doha, Chahinda, and MaastrICCht Collaborators

Abstract

Objectives:In coronavirus disease 2019 (COVID-19), cardiovascular risk factors and myocardial injury relate to increased mortality. We evaluated the extent of cardiac sequelae 6 months after hospital discharge in patients surviving ICU hospitalization for COVID-19.Methods:All survivors of Maastricht-ICU were invited for comprehensive cardiovascular evaluation 6 months after discharge from ICU. Cardiac screening included an electrocardiogram, cardiac biomarkers, echocardiography, cardiac magnetic resonance (CMR) and, wherever indicated, cardiac computed tomography or coronary angiogram.Results:Out of 52 survivors, 81% (n = 42) participated to the cardiovascular follow-up [median follow-up of 6 months, interquartile range (IQR) 6.1-6.7]. Eight patients (19%) had newly diagnosed coronary artery disease (CAD), of which two required a percutaneous intervention. Echocardiographic global longitudinal strain (GLS) was abnormal in 24% and CMR-derived GLS was abnormal in 12%, despite normal left ventricular ejection fraction in all. None of the patients showed elevated T1 relaxation times and five patients (14%) had an elevated T2 relaxation time. Late gadolinium enhancement (LGE) reflecting regional myocardial fibrosis was increased in eight patients (21%), of which three had myocarditis and three had pericarditis.Conclusion:Cardiovascular follow-up at 6 months after ICU-admission for severe COVID-19 revealed that one out of five invasively mechanically ventilated survivors had CAD, a quarter had subclinical left ventricular dysfunction defined as reduced echocardiographic GLS, and 42% of the patients had CMR abnormalities (reduced LVEF, reduced GLS, LGE presence, and elevated T2). On the basis of these findings, long-term cardiovascular follow-up is strongly recommended in all post-IC COVID-19.

Published
2022

37. Rationale and Design of the ISOLATION Study:A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway

Author

Verhaert, Dominique V.M., Linz, Dominik, Chaldoupi, Sevasti Maria, Westra, Sjoerd W., den Uijl, Dennis W., Philippens, Suzanne, Kerperien, Mijke, Habibi, Zarina, Vorstermans, Bianca, ter Bekke, Rachel M.A., Beukema, Rypko J., Evertz, Reinder, Hemels, Martin E.W., Luermans, Justin G.L.M., Manusama, Randolph, Lankveld, Theo A.R., van der Heijden, Claudia A.J., Bidar, Elham, Hermans, Ben J.M., Zeemering, Stef, Bijvoet, Geertruida P., Habets, Jesse, Holtackers, Robert J., Mihl, Casper, Nijveldt, Robin, van Empel, Vanessa P.M., Knackstedt, Christian, Simons, Sami O., Buhre, Wolfgang F.F.A., Tijssen, Jan G.P., Isaacs, Aaron, Crijns, Harry J.G.M., Maesen, Bart, Vernooy, Kevin, Schotten, Ulrich, Verhaert, Dominique V.M., Linz, Dominik, Chaldoupi, Sevasti Maria, Westra, Sjoerd W., den Uijl, Dennis W., Philippens, Suzanne, Kerperien, Mijke, Habibi, Zarina, Vorstermans, Bianca, ter Bekke, Rachel M.A., Beukema, Rypko J., Evertz, Reinder, Hemels, Martin E.W., Luermans, Justin G.L.M., Manusama, Randolph, Lankveld, Theo A.R., van der Heijden, Claudia A.J., Bidar, Elham, Hermans, Ben J.M., Zeemering, Stef, Bijvoet, Geertruida P., Habets, Jesse, Holtackers, Robert J., Mihl, Casper, Nijveldt, Robin, van Empel, Vanessa P.M., Knackstedt, Christian, Simons, Sami O., Buhre, Wolfgang F.F.A., Tijssen, Jan G.P., Isaacs, Aaron, Crijns, Harry J.G.M., Maesen, Bart, Vernooy, Kevin, and Schotten, Ulrich

Abstract

Introduction: Continuous progress in atrial fibrillation (AF) ablation techniques has led to an increasing number of procedures with improved outcome. However, about 30–50% of patients still experience recurrences within 1 year after their ablation. Comprehensive translational research approaches integrated in clinical care pathways may improve our understanding of the complex pathophysiology of AF and improve patient selection for AF ablation. Objectives: Within the “IntenSive mOlecular and eLectropathological chAracterization of patienTs undergoIng atrial fibrillatiOn ablatioN” (ISOLATION) study, we aim to identify predictors of successful AF ablation in the following domains: (1) clinical factors, (2) AF patterns, (3) anatomical characteristics, (4) electrophysiological characteristics, (5) circulating biomarkers, and (6) genetic background. Herein, the design of the ISOLATION study and the integration of all study procedures into a standardized pathway for patients undergoing AF ablation are described. Methods: ISOLATION (NCT04342312) is a two-center prospective cohort study including 650 patients undergoing AF ablation. Clinical characteristics and routine clinical test results will be collected, as well as results from the following additional diagnostics: determination of body composition, pre-procedural rhythm monitoring, extended surface electrocardiogram, biomarker testing, genetic analysis, and questionnaires. A multimodality model including a combination of established predictors and novel techniques will be developed to predict ablation success. Discussion: In this study, several domains will be examined to identify predictors of successful AF ablation. The results may be used to improve patient selection for invasive AF management and to tailor treatment decisions to individual patients.

Published
2022

41. Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway

Author

Verhaert, Dominique V. M., primary, Linz, Dominik, additional, Chaldoupi, Sevasti Maria, additional, Westra, Sjoerd W., additional, den Uijl, Dennis W., additional, Philippens, Suzanne, additional, Kerperien, Mijke, additional, Habibi, Zarina, additional, Vorstermans, Bianca, additional, ter Bekke, Rachel M. A., additional, Beukema, Rypko J., additional, Evertz, Reinder, additional, Hemels, Martin E. W., additional, Luermans, Justin G. L. M., additional, Manusama, Randolph, additional, Lankveld, Theo A. R., additional, van der Heijden, Claudia A. J., additional, Bidar, Elham, additional, Hermans, Ben J. M., additional, Zeemering, Stef, additional, Bijvoet, Geertruida P., additional, Habets, Jesse, additional, Holtackers, Robert J., additional, Mihl, Casper, additional, Nijveldt, Robin, additional, van Empel, Vanessa P. M., additional, Knackstedt, Christian, additional, Simons, Sami O., additional, Buhre, Wolfgang F. F. A., additional, Tijssen, Jan G. P., additional, Isaacs, Aaron, additional, Crijns, Harry J. G. M., additional, Maesen, Bart, additional, Vernooy, Kevin, additional, and Schotten, Ulrich, additional

Published
2022
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43. Global Longitudinal Strain is Incremental to Left Ventricular Ejection Fraction for the Prediction of Outcome in Optimally Treated Dilated Cardiomyopathy Patients

Author

Raafs, Anne G., primary, Boscutti, Andrea, additional, Henkens, Michiel T. H. M., additional, van den Broek, Wout W. A., additional, Verdonschot, Job A. J., additional, Weerts, Jerremy, additional, Stolfo, Davide, additional, Nuzzi, Vincenzo, additional, Manca, Paolo, additional, Hazebroek, Mark R., additional, Knackstedt, Christian, additional, Merlo, Marco, additional, Heymans, Stephane R. B., additional, and Sinagra, Gianfranco, additional

Published
2022
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44. Cardiovascular outcome 6 months after severe coronavirus disease 2019 infection

Author

Raafs, Anne G., primary, Ghossein, Mohammed A., additional, Brandt, Yentl, additional, Henkens, Michiel T.H.M., additional, Kooi, M. Eline, additional, Vernooy, Kevin, additional, Spaanderman, Marc E.A., additional, Gerretsen, Suzanne, additional, van Santen, Susanne, additional, Driessen, Rob G.H., additional, Knackstedt, Christian, additional, van der Horst, Iwan C.C., additional, van Bussel, Bas C.T., additional, Heymans, Stephane R.B., additional, and Ghossein-Doha, Chahinda, additional

Published
2022
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46. Improving diagnosis and risk stratification across the ejection fraction spectrum: the Maastricht Cardiomyopathy registry

Author

Henkens, Michiel T.H.M., primary, Weerts, Jerremy, additional, Verdonschot, Job A.J., additional, Raafs, Anne G., additional, Stroeks, Sophia, additional, Sikking, Maurits A., additional, Amin, Hesam, additional, Mourmans, Sanne G.J., additional, Geraeds, Chrit B.G., additional, Sanders‐van Wijk, Sandra, additional, Barandiarán Aizpurua, Arantxa, additional, Uszko‐Lencer, Nicole H.M.K., additional, Krapels, Ingrid P.C., additional, Wolffs, Petra F.G., additional, Brunner, Han G., additional, Leeuwen, Rick E.W., additional, Verhesen, Wouter, additional, Schalla, Simon M., additional, Stipdonk, Antonius W.M., additional, Knackstedt, Christian, additional, Li, Xiaofei, additional, Abdul Hamid, Myrurgia A., additional, Paassen, Pieter, additional, Hazebroek, Mark R., additional, Vernooy, Kevin, additional, Brunner‐La Rocca, Hans‐Peter, additional, Empel, Vanessa P.M., additional, and Heymans, Stephane R.B., additional

Published
2022
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49. 84 Left atrial reverse remodelling in dilated cardiomyopathy

Author

Nuzzi, Vincenzo, primary, Raafs, Anne, additional, Manca, Paolo, additional, Henkens, Michiel T.h.M., additional, Gregorio, Caterina, additional, Boscutti, Andrea, additional, Verdonschot, Job, additional, Hazebroek, Mark, additional, Knackstedt, Christian, additional, Merlo, Marco, additional, Stolfo, Davide, additional, Sinagra, Gianfranco, additional, and Heymans, Stephane R.B., additional

Published
2021
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50. The prognostic impact of mechanical atrial dysfunction and atrial fibrillation in heart failure with preserved ejection fraction

Author

Weerts, Jerremy, primary, Barandiarán Aizpurua, Arantxa, additional, Henkens, Michiel T H M, additional, Lyon, Aurore, additional, van Mourik, Manouk J W, additional, van Gemert, Mathijs R A A, additional, Raafs, Anne, additional, Sanders-van Wijk, Sandra, additional, Bayés-Genís, Antoni, additional, Heymans, Stephane R B, additional, Crijns, Harry J G M, additional, Brunner-La Rocca, Hans-Peter, additional, Lumens, Joost, additional, van Empel, Vanessa P M, additional, and Knackstedt, Christian, additional

Published
2021
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