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225 results on '"Kmiec, Zbigniew"'

10. Pit Cells and Other Intrahepatic Lymphocytes

Author

Kmieć, Zbigniew, Beck, F., editor, Christ, B., editor, Kriz, W., editor, Kummer, W., editor, Marani, E., editor, Putz, R., editor, Sano, Y., editor, Schiebler, T. H., editor, Schoenwolf, G. C., editor, Zilles, K., editor, and Kmieć, Zbigniew

Published
2001
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12. Cross-Talk of Liver Cells in Response to Endotoxin

Author

Kmieć, Zbigniew, Beck, F., editor, Christ, B., editor, Kriz, W., editor, Kummer, W., editor, Marani, E., editor, Putz, R., editor, Sano, Y., editor, Schiebler, T. H., editor, Schoenwolf, G. C., editor, Zilles, K., editor, and Kmieć, Zbigniew

Published
2001
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13. Summary

Author

Kmieć, Zbigniew, Beck, F., editor, Christ, B., editor, Kriz, W., editor, Kummer, W., editor, Marani, E., editor, Putz, R., editor, Sano, Y., editor, Schiebler, T. H., editor, Schoenwolf, G. C., editor, Zilles, K., editor, and Kmieć, Zbigniew

Published
2001
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16. Hepatic Stellate Cells

Author

Kmieć, Zbigniew, Beck, F., editor, Christ, B., editor, Kriz, W., editor, Kummer, W., editor, Marani, E., editor, Putz, R., editor, Sano, Y., editor, Schiebler, T. H., editor, Schoenwolf, G. C., editor, Zilles, K., editor, and Kmieć, Zbigniew

Published
2001
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19. Kupffer Cells

Author

Kmieć, Zbigniew, Beck, F., editor, Christ, B., editor, Kriz, W., editor, Kummer, W., editor, Marani, E., editor, Putz, R., editor, Sano, Y., editor, Schiebler, T. H., editor, Schoenwolf, G. C., editor, Zilles, K., editor, and Kmieć, Zbigniew

Published
2001
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20. Sinusoidal Endothelial Cells

Author

Kmieć, Zbigniew, Beck, F., editor, Christ, B., editor, Kriz, W., editor, Kummer, W., editor, Marani, E., editor, Putz, R., editor, Sano, Y., editor, Schiebler, T. H., editor, Schoenwolf, G. C., editor, Zilles, K., editor, and Kmieć, Zbigniew

Published
2001
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21. Hepatocytes

Author

Kmieć, Zbigniew, Beck, F., editor, Christ, B., editor, Kriz, W., editor, Kummer, W., editor, Marani, E., editor, Putz, R., editor, Sano, Y., editor, Schiebler, T. H., editor, Schoenwolf, G. C., editor, Zilles, K., editor, and Kmieć, Zbigniew

Published
2001
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22. Introduction — Morphology of the Liver Lobule

Author

Kmieć, Zbigniew, Beck, F., editor, Christ, B., editor, Kriz, W., editor, Kummer, W., editor, Marani, E., editor, Putz, R., editor, Sano, Y., editor, Schiebler, T. H., editor, Schoenwolf, G. C., editor, Zilles, K., editor, and Kmieć, Zbigniew

Published
2001
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31. Perspectives

Author

Kmieć, Zbigniew, Beck, F., editor, Christ, B., editor, Kriz, W., editor, Kummer, W., editor, Marani, E., editor, Putz, R., editor, Sano, Y., editor, Schiebler, T. H., editor, Schoenwolf, G. C., editor, Zilles, K., editor, and Kmieć, Zbigniew

Published
2001
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34. Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer

Author

Zurawa-Janicka, Dorota, primary, Kobiela, Jarek, additional, Slebioda, Tomasz, additional, Peksa, Rafal, additional, Stanislawowski, Marcin, additional, Wierzbicki, Piotr Mieczyslaw, additional, Wenta, Tomasz, additional, Lipinska, Barbara, additional, Kmiec, Zbigniew, additional, Biernat, Wojciech, additional, Lachinski, Andrzej Jacek, additional, and Sledzinski, Zbigniew, additional

Published
2020
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37. Prognostic significance of VHL, HIF1A, HIF2A, VEGFA and p53 expression in patients with clear‑cell renal cell carcinoma treated with sunitinib as first‑line treatment

Author

Wierzbicki, Piotr, primary, Klacz, Jakub, additional, Kotulak‑Chrzaszcz, Anna, additional, Wronska, Agata, additional, Stanislawowski, Marcin, additional, Rybarczyk, Agnieszka, additional, Ludziejewska, Aleksandra, additional, Kmiec, Zbigniew, additional, and Matuszewski, Marcin, additional

Published
2019
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41. FasR and FasL in colorectal cancer

Author

Szarynska, Magdalena, primary, Olejniczak, Agata, additional, Wierzbicki, Piotr, additional, Kobiela, Jaroslaw, additional, Laski, Dariusz, additional, Sledzinski, Zbigniew, additional, Adrych, Krystian, additional, Guzek, Marek, additional, and Kmiec, Zbigniew, additional

Published
2017
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46. Participation of WNT and β-Catenin in Physiological and Pathological Endometrial Changes: Association with Angiogenesis

Author

Kiewisz, Jolanta, Wasniewski, Tomasz, and Kmiec, Zbigniew

Subjects
Article Subject
Abstract

WNT proteins are involved in embryonic development, sex determination, stem cell recruitment, angiogenesis, and cancer. They take part in morphological changes in the endometrium during development, regulate processes of endometrial proliferation and differentiation. This review presents current knowledge about implication of WNT proteins and β-catenin in physiological endometrial functions as well as their involvement in uterine carcinogenesis. Influence of WNT proteins on the formation of blood vessel, taking place both under healthy and pathological conditions, is also considered. Participation of WNT proteins, β-catenin, and inhibitors and inducers of WNT signaling in the process of endometrial angiogenesis is largely unknown. Thus, confirmation of their local and systemic participation in the process of endometrial angiogenesis may in the long term help to establish new diagnostic and therapeutic approaches in conditions associated with the pathology of the female reproductive system.

Published
2015
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49. In vitro generation of pancreatic β-cells for diabetes treatment. I. β-like cells derived from human pluripotent stem cells.

Author

Cierpka-Kmiec, Katarzyna, Wronska, Agata, and Kmiec, Zbigniew

Subjects
ISLANDS of Langerhans transplantation, STEM cell transplantation, BLOOD sugar, CELL differentiation, CELLULAR signal transduction, DIABETES, GENE expression, INSULIN, TYPE 1 diabetes, MEDICAL protocols, MICE, REGENERATION (Biology), RODENTS, TRANSCRIPTION factors, IMMUNOCOMPROMISED patients
Abstract

Diabetes mellitus is a chronic disease that affects hundreds of millions of people worldwide. Type 1 diabetes (T1D) is characterized by the lack of pancreatic β-cells that had been destroyed as a result of an autoimmune response. Therefore, in patients with T1D, the replacement therapy with functional β-cells derived from extrinsic sources could be a preferable option as compared to insulin treatment. Unfortunately, successful transplantation of whole pancreata or pancreatic islets into patients with diabetes is available only to a fraction of them due to the scarcity of donors. The rapid development of cell reprogramming methods made it possible to generate large numbers of human β-like cells derived from human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hiPSCs). This review describes the basis of in vitro differentiaton protocols of β-like cells that mimic changes of the main signaling pathways during the key stages of human and murine pancreas development, which are described first. During the last 15 years it was found that there are no important differences between hESCs and hiPSCs in their differentiation capacities into β-like cells and the expression profiles of the key transcription factors. The in vitro produced β-like cells are immature as demonstrated by functional tests in rodents and single-cell transcriptomic and proteomic analyses. After the transplantation of the b cell progenitors into immunocompromised diabetic mice, a few weeks have to pass before the increased insulin levels in response to glucose load appear. There is a continuous progress in the development of open-type encapsulation devices which allow the vascularization of the transplanted cells and protect them against host's immune cells. The results of the first clinical trial of human partially differentiated endocrine progenitors of b cells transplanted into patients with T1D will be published in the year 2019. It is hoped that further improvements in the techniques of large-scale generation of the β-like cells derived from human pluripotent stem cells will bring us closer to their clinical application as a form of cause-directed therapy for people with diabetes. [ABSTRACT FROM AUTHOR]

Published
2019
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