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523 results on '"Kluge, Michael"'

1. Identifying differential predictors for treatment response to amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia: Results of the COMBINE-study

Author

Galuba, Viktoria, Cordes, Joachim, Feyerabend, Sandra, Riesbeck, Mathias, Meisenzahl-Lechner, Eva, Correll, Christoph U., Kluge, Michael, Neff, Andrea, Zink, Mathias, Langguth, Berthold, Reske, Dirk, Gründer, Gerhard, Hasan, Alkomiet, Brockhaus-Dumke, Anke, Jäger, Markus, Baumgärtner, Jessica, Leucht, Stefan, and Schmidt-Kraepelin, Christian

Published
2024
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4. Analyzing Parallel Applications for Unnecessary I/O Semantics that Inhibit File System Performance

Author

Oeste, Sebastian, Kluge, Michael, Tschüter, Ronny, Nagel, Wolfgang E., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bienz, Amanda, editor, Weiland, Michèle, editor, Baboulin, Marc, editor, and Kruse, Carola, editor

Published
2023
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5. Genome-wide association and transcriptome analysis reveals serum ghrelin to be linked with GFRAL

Author

Wittekind, Dirk Alexander, Scholz, Markus, Kratzsch, Jürgen, Löffler, Markus, Horn, Katrin, Kirsten, Holger, Witte, Veronica, Villringer, Arno, and Kluge, Michael

Subjects
Quantitative Biology - Genomics
Abstract

Objective: Ghrelin is an orexigenic peptide hormone involved in the regulation of energy homeostasis, food intake and glucose metabolism. Serum levels increase anticipating a meal and fall afterwards. Underlying genetic mechanisms of the ghrelin secretion are unknown. Methods: Total serum ghrelin was measured in 1501 subjects selected from the population-based LIFE-ADULT-sample after an overnight fast. A genome-wide association study (GWAS) was performed. Gene-based expression association analyses (transcriptome-wide association study (TWAS)) were done using MetaXcan. Results: In the GWAS, three loci reached genome-wide significance: the WW-domain containing the oxidoreductase-gene (WWOX; p=1.80E-10) on chromosome 16q23.3-24.1 (SNP: rs76823993); the Contactin-Associated Protein-Like 2 gene (CNTNAP2; p=9.0E-9) on chromosome 7q35-q36 (SNP: rs192092592) and the Ghrelin And Obestatin Prepropeptide gene (GHRL; p=2.72E-8) on chromosome 3p25.3 (SNP: rs143729751). In the TWAS, serum ghrelin was negatively associated with RNA expression of the GDNF Family Receptor Alpha Like (GFRAL), receptor of the anorexigenic Growth Differentiation Factor-15 (GDF15), (z-score=-4.288, p=1.81E-05). Furthermore, ghrelin was positively associated with Ribosomal Protein L36 (RPL36; z-score=4.848, p=1.25E-06). Conclusions: Our findings provide evidence of a functional link between two major players of weight regulation, the ghrelin system and the GDF15/GFRAL-pathway.

Published
2020

6. CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1

Author

Hluchý, Milan, Gajdušková, Pavla, Ruiz de los Mozos, Igor, Rájecký, Michal, Kluge, Michael, Berger, Benedict-Tilman, Slabá, Zuzana, Potěšil, David, Weiß, Elena, Ule, Jernej, Zdráhal, Zbyněk, Knapp, Stefan, Paruch, Kamil, Friedel, Caroline C., and Blazek, Dalibor

Published
2022
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8. Clinical manifestations and immunomodulatory treatment experiences in psychiatric patients with suspected autoimmune encephalitis: a case series of 91 patients from Germany

Author

Endres, Dominique, Lüngen, Eva, Hasan, Alkomiet, Kluge, Michael, Fröhlich, Sabrina, Lewerenz, Jan, Bschor, Tom, Haußleiter, Ida Sibylle, Juckel, Georg, Then Bergh, Florian, Ettrich, Barbara, Kertzscher, Lisa, Oviedo-Salcedo, Tatiana, Handreka, Robert, Lauer, Martin, Winter, Klaas, Zumdick, Norbert, Drews, Anna, Obrocki, Jost, Yalachkov, Yavor, Bubl, Anna, von Podewils, Felix, Schneider, Udo, Szabo, Kristina, Mattern, Margarete, Philipsen, Alexandra, Domschke, Katharina, Wandinger, Klaus-Peter, Neyazi, Alexandra, Stich, Oliver, Prüss, Harald, Leypoldt, Frank, and Tebartz van Elst, Ludger

Published
2022
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9. Amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia in Germany (COMBINE): a double-blind randomised controlled trial

Author

Schmidt-Kraepelin, Christian, Cordes, Joachim, Feyerabend, Sandra, Engelke, Christina, Riesbeck, Mathias, Meisenzahl-Lechner, Eva, Gaebel, Wolfgang, Deiß, Martina, Sofie, Natalia, Galuba, Viktoria, Wiechmann, Frank, Janssen, Birgit, Kluge, Michael, Makiol, Christian, Kertzscher, Lisa, Neff, Andrea, Lange, Christina, Englisch, Susanne, Zink, Mathias, Becker, Anna, Muszinski, Sandra, Gründer, Gerhard, Langguth, Berthold, Poeppl, Timm, Frank, Elmar, Kreuzer, Peter, Reske, Dirk, Gouzoulis-Mayfrank, Euphrosyne, Veselinovic, Tanja, Hasan, Alkomiet, Falkai, Peter, Wagner, Elias, Brockhaus-Dumke, Anke, Klos, Bettina, Jäger, Markus, Lang, Fabian, Kling-Lourenço, Paulo, Baumgärtner, Jessica, Dreimüller, Nadine, Hiemke, Christoph, Leucht, Stefan, Heres, Stephan, Leucht, Claudia, Assion, Hans-Jörg, Kis, Bernhard, Zilles-Wegner, David, Kahl, Kai, Correll, Christoph, Verde, Pablo-Emilio, Kolbe, Henrike, Rottmann, Anika, Correll, Christoph U, and Poeppl, Timm B

Published
2022
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15. A randomized double-blind controlled trial to assess the benefits of amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill schizophrenia patients (COMBINE): methods and design

Author

Schmidt-Kraepelin, Christian, Feyerabend, Sandra, Engelke, Christina, Riesbeck, Mathias, Meisenzahl-Lechner, Eva, Gaebel, Wolfgang, Verde, Pablo-Emilio, Kolbe, Henrike, Correll, Christoph U., Leucht, Stefan, Heres, Stephan, Kluge, Michael, Makiol, Christian, Neff, Andrea, Lange, Christina, Englisch, Susanne, Zink, Mathias, Langguth, Berthold, Poeppl, Timm, Reske, Dirk, Gouzoulis-Mayfrank, Euphrosyne, Gründer, Gerhard, Hasan, Alkomiet, Brockhaus-Dumke, Anke, Jäger, Markus, Baumgärtner, Jessica, Wobrock, Thomas, and Cordes, Joachim

Published
2020
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17. A multi-centre, randomised, double-blind, placebo-controlled clinical trial of methylphenidate in the initial treatment of acute mania (MEMAP study)

Author

Hegerl, Ulrich, Mergl, Roland, Sander, Christian, Dietzel, Jens, Bitter, Istvan, Demyttenaere, Koen, Gusmão, Ricardo, González-Pinto, Ana, Zorrilla, Iñaki, Alocén, Adriana García, Sola, Victor Perez, Vieta, Eduard, Juckel, Georg, Zimmermann, Ulrich S., Bauer, Michael, Sienaert, Pascal, Quintão, Sónia, Edel, Marc-Andreas, Bolyos, Csilla, Ayuso-Mateos, Jose Luis, López-García, Pilar, and Kluge, Michael

Published
2018
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21. Leveraging Energy Flexibility with Electric Vehicles

Author

Schert, Kelaja, Biedenbach, Florian, Müller, Thomas, Kluge, Michael, and Nochta, Zoltán

Subjects
flexibility, smart charging, aggregator, optimization, market development, BEV, energy
Abstract

In this paper, we present an implementation of price-optimized charging based on energy flexibility. Three fleet operators determine the energy demand needed to charge battery electric vehicles (BEVs) at a specific time and share this information as so-called power corridors with an energy aggregator. The aggregation system collects the predicted power corridors from the charging systems and calculates the flexible energy demand. A trading system receives the aggregated information and returns the power prices to the aggregation system. As a result, the aggregation system calculates and delivers charge plans for each site of the fleet operator with optimized power prices to the charging systems. This study can contribute to a new energy market communication system by providing insights on how to leverage the energy flexibility BEVs can offer for a data-driven energy system.

Published
2023
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23. Data from Inhibition of CD95/CD95L (FAS/FASLG) Signaling with APG101 Prevents Invasion and Enhances Radiation Therapy for Glioblastoma

Author

Blaes, Jonas, primary, Thomé, Carina M., primary, Pfenning, Philipp-Niclas, primary, Rübmann, Petra, primary, Sahm, Felix, primary, Wick, Antje, primary, Bunse, Theresa, primary, Schmenger, Torsten, primary, Sykora, Jaromir, primary, von Deimling, Andreas, primary, Wiestler, Benedikt, primary, Merz, Christian, primary, Jugold, Manfred, primary, Haberkorn, Uwe, primary, Abdollahi, Amir, primary, Debus, Jürgen, primary, Gieffers, Christian, primary, Kunz, Claudia, primary, Bendszus, Martin, primary, Kluge, Michael, primary, Platten, Michael, primary, Fricke, Harald, primary, Wick, Wolfgang, primary, and Lemke, Dieter, primary

Published
2023
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24. Supplementary Materials and Methods; Supplmentary Tables 1-5; Supplementary Figures 1-5 from APG350 Induces Superior Clustering of TRAIL Receptors and Shows Therapeutic Antitumor Efficacy Independent of Cross-Linking via Fcγ Receptors

Author

Gieffers, Christian, primary, Kluge, Michael, primary, Merz, Christian, primary, Sykora, Jaromir, primary, Thiemann, Meinolf, primary, Schaal, René, primary, Fischer, Carmen, primary, Branschädel, Marcus, primary, Abhari, Behnaz Ahangarian, primary, Hohenberger, Peter, primary, Fulda, Simone, primary, Fricke, Harald, primary, and Hill, Oliver, primary

Published
2023
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25. Data from APG350 Induces Superior Clustering of TRAIL Receptors and Shows Therapeutic Antitumor Efficacy Independent of Cross-Linking via Fcγ Receptors

Author

Gieffers, Christian, primary, Kluge, Michael, primary, Merz, Christian, primary, Sykora, Jaromir, primary, Thiemann, Meinolf, primary, Schaal, René, primary, Fischer, Carmen, primary, Branschädel, Marcus, primary, Abhari, Behnaz Ahangarian, primary, Hohenberger, Peter, primary, Fulda, Simone, primary, Fricke, Harald, primary, and Hill, Oliver, primary

Published
2023
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26. Supplementary Materials and Methods, Figures S1 - S4 from Inhibition of CD95/CD95L (FAS/FASLG) Signaling with APG101 Prevents Invasion and Enhances Radiation Therapy for Glioblastoma

Author

Blaes, Jonas, primary, Thomé, Carina M., primary, Pfenning, Philipp-Niclas, primary, Rübmann, Petra, primary, Sahm, Felix, primary, Wick, Antje, primary, Bunse, Theresa, primary, Schmenger, Torsten, primary, Sykora, Jaromir, primary, von Deimling, Andreas, primary, Wiestler, Benedikt, primary, Merz, Christian, primary, Jugold, Manfred, primary, Haberkorn, Uwe, primary, Abdollahi, Amir, primary, Debus, Jürgen, primary, Gieffers, Christian, primary, Kunz, Claudia, primary, Bendszus, Martin, primary, Kluge, Michael, primary, Platten, Michael, primary, Fricke, Harald, primary, Wick, Wolfgang, primary, and Lemke, Dieter, primary

Published
2023
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31. HPC File Systems in Wide Area Networks: Understanding the Performance of Lustre over WAN

Author

Aguilera, Alvaro, Kluge, Michael, William, Thomas, Nagel, Wolfgang E., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Kaklamanis, Christos, editor, Papatheodorou, Theodore, editor, and Spirakis, Paul G., editor

Published
2012
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35. Pattern Matching and I/O Replay for POSIX I/O in Parallel Programs

Author

Kluge, Michael, Knüpfer, Andreas, Müller, Matthias, Nagel, Wolfgang E., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Sips, Henk, editor, Epema, Dick, editor, and Lin, Hai-Xiang, editor

Published
2009
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36. Trace-Based Analysis and Optimization for the Semtex CFD Application – Hidden Remote Memory Accesses and I/O Performance

Author

Mickler, Holger, Knüpfer, Andreas, Kluge, Michael, Müller, Matthias S., Nagel, Wolfgang E., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, César, Eduardo, editor, Alexander, Michael, editor, Streit, Achim, editor, Träff, Jesper Larsson, editor, Cérin, Christophe, editor, Knüpfer, Andreas, editor, Kranzlmüller, Dieter, editor, and Jha, Shantenu, editor

Published
2009
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37. Analysis of Linux Scheduling with VAMPIR

Author

Kluge, Michael, Nagel, Wolfgang E., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Rangan, C. Pandu, editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Shi, Yong, editor, van Albada, Geert Dick, editor, Dongarra, Jack, editor, and Sloot, Peter M. A., editor

Published
2007
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38. Quality Assurance for Clusters: Acceptance-, Stress-, and Burn-In Tests for General Purpose Clusters

Author

Müller, Matthias S., Juckeland, Guido, Jurenz, Matthias, Kluge, Michael, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Perrott, Ronald, editor, Chapman, Barbara M., editor, Subhlok, Jaspal, editor, de Mello, Rodrigo Fernandes, editor, and Yang, Laurence T., editor

Published
2007
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42. Peripheral monocytes are functionally altered and invade the CNS in ALS patients

Author

Zondler, Lisa, Müller, Kathrin, Khalaji, Samira, Bliederhäuser, Corinna, Ruf, Wolfgang P., Grozdanov, Veselin, Thiemann, Meinolf, Fundel-Clemes, Katrin, Freischmidt, Axel, Holzmann, Karlheinz, Strobel, Benjamin, Weydt, Patrick, Witting, Anke, Thal, Dietmar R., Helferich, Anika M., Hengerer, Bastian, Gottschalk, Kay-Eberhard, Hill, Oliver, Kluge, Michael, Ludolph, Albert C., Danzer, Karin M., and Weishaupt, Jochen H.

Published
2016
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43. Statistical Methods for Automatic Performance Bottleneck Detection in MPI Based Programs

Author

Kluge, Michael, Knüpfer, Andreas, Nagel, Wolfgang E., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Sunderam, Vaidy S., editor, van Albada, Geert Dick, editor, Sloot, Peter M. A., editor, and Dongarra, Jack J., editor

Published
2005
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44. Knowledge Based Automatic Scalability Analysis and Extrapolation for MPI Programs

Author

Kluge, Michael, Knüpfer, Andreas, Nagel, Wolfgang E., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Cunha, José C., editor, and Medeiros, Pedro D., editor

Published
2005
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48. Non-Right Handedness is Associated with More Time Awake After Sleep Onset and Higher Daytime Sleepiness Than Right Handedness: Objective (Actigraphic) and Subjective Data from a Large Community Sample

Author

Taubert,Hilde, Schroeter,Matthias L, Sander,Christian, Kluge,Michael, Taubert,Hilde, Schroeter,Matthias L, Sander,Christian, and Kluge,Michael

Abstract

Hilde Taubert,1 Matthias L Schroeter,2– 4 Christian Sander,1,4,* Michael Kluge1,* 1Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; 2Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 3Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany; 4Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany*These authors contributed equally to this workCorrespondence: Michael Kluge, Department of Psychiatry and Psychotherapy University of Leipzig, Semmelweisstr 10, Leipzig, 04103, Germany, Tel +49 341/97 24673, Fax +49 341/97 24539, Email Michael.Kluge@medizin.uni-leipzig.dePurpose: Handedness has been linked to various physiological and pathological phenomena including memory function and psychiatric disorders. Also for sleep, several studies have reported associations. However, large-scale studies including a broad age span of participants and studies analyzing women and men separately are lacking.Methods: Therefore, objective sleep data were determined using at-home actigraphy from 1764 healthy participants (18 to 80 years, 908 women), averaging five consecutive nights. In addition, subjective sleep-related data were captured by self-report diaries, the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS) and the Morningness-Eveningness-Questionnaire (MEQ). Handedness was determined with the Edinburgh Handedness Inventory (EHI) providing information on the direction (left vs right) and the degree of handedness (strong vs weak). To address the potential endocrine effects, premenopausal women (≤ 45 years) and postmenopausal women (≥ 55 years) were analyzed separately. This was also done for men.Results: The degree and direction of handedness were correlated with “wake after sleep onset” (WASO) in the total sample and all women (the more right-handed/lateralized the shorter WASO

Published
2022

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