Search

Your search keyword '"Klinik tanı"' showing total 9 results
Start Over Descriptor "Klinik tanı"
9 results on '"Klinik tanı"'

1. Determination of Diagnostic Value of cELISA for the Diagnosis of Anaplasmosis in Clinically Suspected Ruminants.

Author

SELÇUK, Özgür, ALVER, Oktay, ÇATIK, Serkan, AYDIN, Levent, and ŞENLİK, Bayram

Subjects
*ENZYME-linked immunosorbent assay, *ANAPLASMOSIS, *VETERINARY diagnosis, *VETERINARY serology, *ANIMAL diseases, *RUMINANTS, *DIAGNOSIS
Abstract

The aim of this study was to determine diagnostic value of cELISA in anaplasmosis in clinically suspected animals and to compare the cELISA results with the clinical examination results. For this purpose a total of 720 ruminants (457 cattle, 146 sheep, 117 goat) were examined in terms of clinical signs. Eighty-eight ruminants consisting of 61 cattle, 11 sheep and 16 goat which had the symptoms of anemia fever icterus weakness depression and lack of appetite were selected for the study. Blood samples were collected from the jugular vein of all clinically suspected animals and serum samples were separated. A commercially available competitive enzyme-linked immunosorbent assay (C-EUSA) kit was used for determine antibodies to Anaplasma species. cELISA based diagnosis revealed that 47 of 88 serum samples (53 4%) were positive for anaplasmosis. In serological examination Anaplasma specific antibodies were determined in 45.9% of cattle, 63 6% of sheep and 56 2% of goat* Seropositive rate was statistically differ among the age groups of cattle and the highest seropositvity rate was found in <12 month age (P<0.005). However no difference was found in the seropositivity rate of Anaplasma in sheep and goat in relation to age group From the data obtained in this study it can be concluded that clinical findings are not sufficient criteria for the diagnosis of anaplasmosis and must be supported by serological examination. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

2. Kanda ve dokularda mycobacterium bovis etkeninin moleküler ve sito-histopatolojik yöntemlerle gösterilmesi

Author

Akdeşir, Ezgi, Kahraman, M. Müfit, Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Veteriner Patoloji Anabilim Dalı., Kahraman, Müjdat Müfit, and Patoloji (Veterinerlik) Ana Bilim Dalı

Subjects
Veterinary Medicine, Hematologic tests, Veteriner Hekimliği, ICC, IHK, Perifer kandan tanı, Histopathology, Diagnosis from peripheral blood, Immunohistochemistry, Mycobacterium bovis, Clinical diagnosis, Mycobacterium, Polymerase chain reaction, PCR, Histopatoloji, Diagnosis, İSK, ZN, PZR, Cytology, Klinik tanı, IHC
Abstract

Bu çalışmada farklı çiftliklerde tüberkülin deri testinde pozitif bulunan 2 yaş üzeri ineklerden oluşan 30 adet tüberkülozlu sığırda (çalışmanın deney grubu) Mycobacterium bovis etkeninin varlığının periferik kanda saptanabilmesinde kullanılabilecek, alternatif bir tanı yöntemi denemesi ve rutin histopatoloji, immunohistokimya (İHK), Polimeraz Zincir Reaksiyonu (PZR) farklı tanı yöntemlerinin karşılaştırılması amaçlanmıştır. Deney ve kontrol grubuna ait hayvanların kesimi sonrası kan ve doku örnekleri alınarak, taze dokularda PZR, formaldehitte tespit edilmiş dokulardan hazırlanan parafin blok kesitlerinde ise Hematoksilen-Eozin (HE), Ziehl-Neelsen (ZN) ve İHK yöntemi ile boyama uygulanmıştır. Santrifüje edilen kanların 'buffy coat'; lökosit katmanında PZR ve bu katmandan hazırlanan frotilere immunositokimya (İSK) uygulanmıştır. Deney grubundaki hayvanların 27'sinde öncelikli olarak akciğer ve mediastinal lenf düğümlerinde, ilave olarak plöra ve karaciğerde kazeifiye-kalsifiye olmuş tipik tüberkül yapısı gözlenmiştir. Organlarında makroskobik lezyon (nodül, tüberkül) gözlenmeyen 4 hayvandan ikisinde spesifik olmayan lenfadenopati gözlenmiştir. Tipik makroskobik lezyon (tüberkül) gösteren olgularda ve ek olarak lenfadenopati gözlenen 2 olgudan bir tanesinde histopatolojik muayenede tipik tüberkül granulomu yapısı gözlenmiştir. Histopatolojik incelemeleri takiben yapılan ZN boyamalarda 20 olgu tüberkülozla uyumlu bulunmuştur. Deney grubundaki hayvanların akciğer, mediastinal lenf düğümü ve karaciğer dokularında yapılan İHK boyamalarında 30 hayvanının 25 tanesinde; lökosit katmanından yapılan İSK boyamalarının ise 3 tanesinde pozitif etken boyanmasına rastlanmıştır. Tespit edilmeden aynı dokularda gerçekleştirilen PZR'de 18 hayvana ait dokuda; lökosit katmanı PZR'sinde ise 14 tanesinde pozitiviteye rastlanmıştır. İHK incelemelerinde pozitif boyanmış etkenlere, nekroz alanlarını çevreleyen bağ dokuda serbest şekilde; makrofajların, dev hücrelerinin, nadiren lenfositlerin ve fibrositlerin sitoplazmalarında rastlanmıştır. İSK incelemelerinde ise pozitif reaksiyon mononükleer lökosit sitoplazmalarında görülmüştür. Kontrol grubunda ise İSK'da 10, ,dokuda PZR'de1, kanda yapılan PZR'da 2 hayvanda pozitif reaksiyon saptanmış diğer yöntemlerde herhangi bir pozitiviteye rastlanmamıştır.Sonuç olarak çalışmamızda Mycobacterium bovis etkenine ait moleküllerin periferik kandaki varlığı ve bu molekülleri saptamaya yönelik yöntemlerin kanda sığır tüberkülozunun tanısında kullanılabileceği gösterilmiştir. Klasik olarak ZN boyama ile yapılacak tüberküloz tanısının her zaman hassasiyet göstermediği ve teşhiste diğer yöntemlere ihtiyaç olduğu gözlemlenmiştir. Bu nedenle destekleyici diğer tanı yöntemi veya yöntemlerinin kullanılmasında fayda olacağı açıktır. Kullanılan yöntemlerden İHK'nın, etkili sonuç verdiği, kandan yapılan testlerde ise PZR'nin İSK'ya kıyasla daha etkili olduğu gözlenmiştir. Tüberküloz hastalığının kesin teşhisinde kullanılan tekniklerin birinin diğerine üstünlüğünden ziyade birbirini tamamlayıcılığından ve bir arada kullanıldığında teşhisin hem daha hızlı hem de daha güvenilir olduğundan bahsetmek daha yerinde olacaktır. Çalışmanın temel hedefini oluşturan, erken tanıya ve PPD ile ön tanının doğrulanmasına imkan sağlayacak 'etkenin kan-lökosit katmanındaki tesbit edilebilirliği uygulamasının, hangi safhalarda, ne derece tercih edilebileceğini net olarak ortaya koyabilmek, yöntemi rutin kullanıma sunabilmek için ileri çalışmalar gerekmektedir. In this study it was aimed to provide an alternative method applicable to peripheral blood and compare various methods for diagnosing bovine tuberculosis by sampling from 30 cows older than 2 years, from various farms and found to be positive in intradermal tuberculin test. Following the slaughter of animals in experiment and control group, blood and tissue samples were collected. Polymerase chain reaction (PCR) was applied to the fresh tissue samples and Hematoxyline&Eosin (HE), Ziehl-Neelsen (ZN) and immunohistochemistry (IHC) was applied to the formalin fixed, paraffin embedded tissues. The buffy-coat extracted from the blood by centrifugation was further processed with PCR and the buffy-coat smears with Immunocytochemistry (ICC) method. In 27 of the experiment group classical tubercle lesion was observed. In the 4 animals which did not show characteristic macroscopic lesion, nonspecific lymphadenopathy was observed. In animals showing typical macroscopic lesion and additionally in one of the two lymphadenopathic cows, routine HE examination revealed typical granuloma structure. In examination of ZN stained slides, 20 animals of the experiment group was found to be consistent with tuberculosis. In the lungs, mediastinal lymphnodes and liver of the experiment group, 25 animals revealed positive staining against M.bovis in IHC and 3 animals in ICC. Tissues of 18 animals and buffy-coat of 14 animals were found to be PCR positive for mycobacteria. Positive staining in IHC was observed surrounding the necrosis in the connective tissue and intracytoplasmically in macrophages, giant-cells, rarely in lymphocytes and fibrocytes. Positive staining in ICC is observed intracytoplasmically in mononuclear leukocytes. Of the control group (n: 30); 10 in ICC and in PCR examination of the buffy coat 2 animals and of the tissue 1 animal were found to be positive. Other tests of the control group revealed negative results.As a conclusion, this study has shown the possibility of detecting the molecules of the agent in peripheral blood and diagnostic feature of the blood in bovine tuberculosis. As a usual practice, use of ZN staining for the diagnosis of bovine tuberculosis is found to lack sensitivity and the need for supportive diagnostic tests is considered to be necessary. It was shown that IHC in tissue and PCR in blood samples was the most effective method to diagnose the disease. For the quick and accurate diagnosis of bovine tuberculosis, rather than the superiority of diagnostic methods it is more suitable to talk about the complementarity of these methods. Further studies are urgent to have precise information about the utility of the method based on the theory of detecting agent components in buffy-coat. 66

Published
2020

3. Otoimmün Büllöz Hastalıkların Klinik Tanısı.

Author

Küçükoğlu, Rifkiyeu and Babuna, Goncagül

Subjects
*AUTOIMMUNE disease diagnosis, *PEMPHIGUS diagnosis, *SKIN disease diagnosis, *AUTOIMMUNE diseases, *PEMPHIGUS, *SKIN diseases
Abstract

The autoimmune bullous diseases were diagnosed on the clinical and histopathological basis, before the introduction of the immunological assays. However, not the clinical features, but the classification of the diseases has recently changed during the immunological development. According to this new classification, pemphigus group diseases include, pemphigus vulgaris, pemphigus vegetans, pemphigus foliaceus, pemphigus erythematosus, endemic pemphigus, IgA pemphigus, pemphigus herpetiformis, paraneoplastic pemphigus, and drug-induced pemphigus. The subepidermal bullous diseases are classified as pemphigoid group diseases, epidermolysis bullosa acquisita, dermatitis herpetiformis, and linear IgA bullous dermatosis. The pemphigoid-group diseases consist of bullous pemphigoid, childhood bullous pemphigoid, localised bullous pemphigoid, drug-induced pemphigoid, anti p200 pemphigoid, pemphigoid gestationes, pemphigoid nodularis, and cicatricial pemphigoid. In this review, the clinical features of the autoimmune bullous diseases are discussed according to the above mentioned classification. [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

4. Cinsel İşlev Bozuklukları Kliniğine Başvuran Olgularda Başvuru Yakınması ile Klinik Tanı Arasındaki İlişki.

Author

YILDIRIM, Ejder Akgün, AKYÜZ, Fatma, HACIOĞLU, Munevver, EŞSİZOĞLU, Altan, ÇAKMAK, Ayşen COŞUT, ÇAKMAK, Engin, and ERDİMAN, Sezgin

Subjects
*DIAGNOSIS of female reproductive organ diseases, *IMPOTENCE, *MALE reproductive organ diseases, *SEXUAL dysfunction, *PREMATURE ejaculation, *ANALYSIS of variance, *CONFIDENCE intervals, *OUTPATIENT services in hospitals, *RETROSPECTIVE studies, *DIAGNOSIS
Abstract

The data on the relationship between presenting complaint and diagnosis of sexual dysfunction (SD) in diagnostic evaluation of patients who apply with sexual problems are limited. In this study, we investigated the diagnosis of patients who apply to the SD clinic and the relationship between presenting complaint and clinical diagnosis. All outpatients who applied to the SD clinic of Bakırköy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery between January 2006 and December 2007 were included in this study. The records of semi-structured case evaluation forms of outpatients diagnosed with SD according to the DSM-IV-TR criteria were analyzed retrospectively. The results were evaluated statistically in 95% confidence interval. 440 outpatients were included (242 men and 196 women) in this study. The mean age of women was 30.71±7.73 years and of men was 35.5±9.59 years. Vaginismus (in 41.0% of cases) and anorgasmia (in 17.0%) were the most common SD in females, while premature ejaculation (45.5%) and erectile dysfunction (27.7%) in males. We found significant relationship between present complaint and clinical diagnosis in male outpatients who applied alone (p<0.001). For men who applied with their partners, this relationship showed negative significance (p<0.001). For women, regardless of whether they applied alone or with their partners, significant and positive relationship was observed between complaints and clinical diagnosis (p<0.001). There is a weak consistency between presenting complaint and clinical diagnosis in men who apply with their partners and in men whose clinical diagnosis is premature ejaculation. Detailed diagnostic interview should be done especially in men applying with their partners, even if a complaint is not stated. This condition in men may be related to false sexual beliefs in society which are mostly based on male sexuality, both in men and women. [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

5. Çocuklarda eritrosit sedimantasyon hızını 100 mm/saat'in üzerine çıkaran hastalıkların incelenmesi.

Author

Aydoğan, Ümit, Sarı, Oktay, Akbulut, Halil, Sarıcı, S.Ümit, Sağlam, Kenan, and Özcan, Okan

Subjects
*BLOOD sedimentation, *LABORATORY test panels, *ERYTHROCYTES, *JUVENILE diseases, *HOSPITAL care of children, *PEDIATRIC nephrology
Abstract

The erythrocyte sedimentation rate is a time-dependent, easily applied and a commonly used laboratory test by scientists to determine diagnosis and prognosis measuring the sedimentation rate of red blood cells. In this study we investigated the diagnostic profiles and diseases of children with very high sedimentation rates. The files of the patients hospitalized at the Department of Pediatrics were retrospectively reviewed. Age, gender, erythrocyte sedimentation rate, diagnosis and hospitalization length of children with a sedimentation rate over 100 mm/h were recorded and analyzed. Sixty six patients were included in the study. The mean erythrocyte sedimentation rate was 111.42±14.83 mm/h. When the distribution according to the disease groups was analyzed, the highest rate (54.5%) was of infectious diseases. Of all the patients, 16.7% and 12.1% were in the groups of a rheumatismal disease and a kidney disease, respectively. Among the infectious diseases, pneumonia was the most commonly encountered diagnosis in 9 patients (25%). Among the patients with rheumatologic diseases, acute rheumatic fever was the most frequently encountered diagnosis (45.5%). Acute pyelonephritis was the most common diagnosis encountered in patients with kidney diseases (50%). High erythrocyte sedimentation rates were most commonly associated with infectious diseases. [ABSTRACT FROM AUTHOR]

Published
2010

6. Ectopic intra-abdominal fascioliasis.

Author

Öngören, Ali Ulvi, Özkan, Ayşegül Taylan, Demırel, Arif Hakan, Üstün, Hüseyin, and Dönmez, Mustafa

Subjects
*FASCIOLIASIS, *FASCIOLA hepatica, *ABDOMINAL surgery, *ABDOMINAL pain
Abstract

Human fascioliasis, caused by Fasciola hepatica, is emerging as an important chronic zoonotic disease in many areas of the world, including Turkey. It primarily involves the liver and may also cause severe damage in the tissue. Herein we report on a patient with ectopic intraabdominal fascioliasis that presented to our clinic with abdominal pain and distention. Physical and radiological examination as well as an exploratory laparotomy revealed a 10 × 10-cm mass in the splenic flexura of the colon and multiple cystic formations in the liver, spleen, and omentum, which mimicked peritoneal carcinoma. Histopathological examination revealed a granulomatous reaction due to parasites. Left hemicolectomy and partial omental resection were performed. Subsequent serological and histological examinations resulted in the diagnosis of fascioliasis. Laparotomy and treatment with triclabendazole were well tolerated by the patient. Ectopic cases of fascioliasis cannot be easily distinguished from peritoneal carcinoma involving the colon, mesocolon, and omentum, and physicians must therefore be aware of this form of infestation. [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
View/download PDF

7. Klinik ve Elektrofizyolojik Tanılar Arasındaki Tutarlılık.

Author

Okuyucu, Esra E., Turhanoğlu, Ayfle D., Duman, Taflkin, Savafl, Nazan, Mengüllüoğlu, Necdet, and Melek, Ismet M.

Subjects
*ELECTROMYOGRAPHY, *DIAGNOSIS, *ELECTROPHYSIOLOGY, *TESTING, *CLINICS, *MEDICAL referrals, *NEUROLOGISTS, *ORTHOPEDICS, *NEUROSURGEONS
Abstract

Objective: The aim of this study was to provide information concerning the impact of electrophysiological tests in the clinical management and diagnosis of patients, and to evaluate the consistency between referring clinical diagnoses and electrophysiological diagnoses. Patients and Methods: The study included 957 patients referred to the electroneuromyography (ENMG) laboratory from different clinics with different clinical diagnoses in 2008. Demographic data, referring clinical diagnoses, the clinics where the requests wanted, and diagnoses after ENMG testing were recorded and statistically evaluated. Results: In all, 957 patients [644 (67.3%) female and 313 (32.7%) male] were included in the study. Mean age of the patients was 45.40 ± 14.54 years. ENMG requests were made by different specialists; 578 (60.4%) patients were referred by neurologists, 122 (12.8%) by orthopedics, 140 (14.6%) by neurosurgeons, and 117 (12.2%) by physical treatment and rehabilitation departments. According to the results of ENMG testing, 513 (53.6%) patients' referrals were related to their referral diagnosis, whereas 397 (41.5%) patients had normal ENMG test results, and 47 (4.9%) patients had a diagnosis that differed from the referring diagnosis. Among the relation between the referral diagnosis and electrophysiological diagnosis according to the clinics where the requests were made, there was no statistical difference (p= 0.794), but there were statistically significant differences between the support of different clinical diagnoses, such as carpal tunnel syndrome, polyneuropathy, radiculopathy-plexopathy, entrapment neuropathy, and myopathy based on ENMG test results (p< 0.001). Conclusion: ENMG is a frequently used neurological examination. As such, referrals for ENMG can be made to either support the referring diagnosis or to exclude other diagnoses. This may explain the inconsistency between clinical referring diagnoses and diagnoses following ENMG. [ABSTRACT FROM AUTHOR]

Published
2009

8. Analysis of hospitalized patients in nephrology clinic

Author

Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Bilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Aile Hekimliği Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı., Ayar, Yavuz, Ersoy, Alparslan, Sayılar, Emel Işıktaş, Yıldız, Abdülmecit, Oruç, Ayşegül, Orhan, Safiye, Şanlı, Cemile, Ceylan, Alper, Tırnova, Zelal Şahin, Eylemer, Eda, Çamcı, Nihal Yücel, Göktaş, Sibel Yorulmaz, Akalın, Emin Halis, and Şahin, Ahmet Bilgehan

Subjects
Hospitalization time and period, Kronik böbrek yetmezliği, Chronic renal failure, Klinik tanı, Yatış süresi ve dönemi, Clinical diagnosis
Abstract

Ülkemizde artan nufüs ve yaşam beklentisi ile birlikte kronik hastalık görülme sıklığında belirgin bir artış gözlenmektedir. Kronik böbrek hastalıklarının etyolojisinde diyabet, hipertansiyon ve glomerülonefritler ön sıralarda yer almaktadır. Hastane kayıtları retrospektif değerlendirildiğinde toplam yatışların 1/5’inde genitoüriner, kardiyovasküler ve dolaşım sistemi ile ilişkili hastalıklar görülmektedir. Çalışmamızda Ocak 2013 Ocak-Aralık 2014 ayları arasında klinikte takip edilen 295 kadın, 346 erkek, toplam 641 hasta değerlendirildi. Hastalar klinik, demografik, laboratuar değerlerine göre analiz edildi. Kliniğimizde en sık yatış tanıları %27.17 kronik böbrek yetmezliği (KBY), %21.3 renal transplantasyon hastası (transplantasyon hazırlık, enfeksiyon vb.), %15.36 proteinüri etyoloji ve %7.7 akut böbrek yetmezliği idi. Hastalarımızın 2013 ve 2014 yıllarında sırasıyla; %93.2 ve %92.8’i şifa veya haliyle taburcu olurken, %3.3 ve %3.9’u kaybedilmiş, %3.6 ve %3.3’ü yoğun bakım ünitesine veya diğer kliniklere devredilmişti. Yatış süresi hastaların ortalama yıllara göre 14 (2-106) ve 15 (2-111) gün idi. Hastaların 2013 ve 2014 yıllarında %36.5ve %42.1’inde enfeksiyon mevcuttu. Hastaların yıllara göre %31.2 ve %23.4’ü hemodiyalize girerken, %29.4 ve %33.9’u immünsüpresif tedavi kullanmaktaydı. Sonuç olarak diyaliz tedavisi ve uzun süreli yatışlar enfeksiyon görülme sıklığı ile mortaliteyi arttırmaktadır. In our country, incidence of chronic diseases is increased significantly by high rate of population growth and long life expectancy. In the etiology of chronic renal disease leading causes are diabetes, hypertension and glomerulonephritis. By assessing of the hospital records retrospectively, the diseases, which are related to genitourinary, cardiovascular and circulatory systems, were major causes in 1/5 of total hospitalized patients. In our study, 295 women, 346 men, total of 641 patients who were followed at the clinic between January 2013 and December 2014, were evaluated. Clinical, demographic and laboratory data of patients were analyzed. Common causes for hospitalization were chronic renal failure (CRF) 27.17%; renal transplant patients 21.3% (for transplant preparation, infection, etc.); etiology of proteinuria %15.36; and acute renal failure (ARF) 7.7% in our clinic. 93.2% and 92.8% of our patients were discharged with recovery or current state, 3.6% and 3.3% of them were died, 3.55% and 3.29% were transferred to intensive care unit or other clinics, respectively in 2013 and 2014. The mean of hospitalization time were 14 (2-106) and 15 (2-111) days. 36.5% and 42.1% of patients had infection in 2013 and 2014. 31.2% and 23.4% of patients were receiving hemodialysis, 29.4% and 33.9% of patients were taking immunosuppressive therapy. As result, dialysis therapy and long-term hospitalization increase frequency of infection and mortality.

Published
2015

9. The value of serum thyroglobulin levels in clinical diagnosis

Author

Öztürk, Emel, Uludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı., Güneş, İlknur, and Sarıkaya, İsmet

Subjects
Serum tiroglobulin, Serum thyroglobulin, Klinik tanı, Clinical diagnosis
Abstract

Bu makalede tiroglobulin salınımını düzenleyen mekanizmalar ve serum tiroglobulin ölçümlerinin klinik değeri vurgulanmış çeşitli patolojilerdeki tanısal uygulama alanları tartışılmış ve konu ile ilgili literatür gözden geçirilmiştir. In this article, the mechanisms of regulation of thyroglobulin secretion and the clinical value of serum thyroglobulin measurements in clinical practice and its diagnostic applications have been emphasized and the literature were evaluated.

Published
1992

Catalog

Books, media, physical & digital resources
See catalog results