1. Anticancer activity of ferrocenylthiosemicarbazones.
- Author
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Sandra CM, Elena K, Marcos FA, Elena MK, Arturo RR, Teresa RA, and Marcos MG
- Subjects
- Antineoplastic Agents chemical synthesis, Cell Line, Tumor, Cisplatin pharmacology, Coordination Complexes chemical synthesis, Crystallography, X-Ray, Drug Screening Assays, Antitumor, Ferrous Compounds chemical synthesis, Humans, Magnetic Resonance Spectroscopy, Metallocenes, Structure-Activity Relationship, Thiosemicarbazones chemical synthesis, Antineoplastic Agents pharmacology, Coordination Complexes pharmacology, Ferrous Compounds pharmacology, Thiosemicarbazones pharmacology
- Abstract
Aliphatic and aromatic ferrocenylthiosemicarbazones were synthesized. The characterization of the new ferrocenylthiosemicarbazones was done by IR, (1)H-NMR and (13)C-NMR spectroscopy, elemental analysis and X-ray diffraction studies. The biological activity of the obtained compounds was assessed in terms of anticancer activity. Their activity against U251 (human glyoblastoma), PC-3 (human prostatic adenocarcinoma), K562 (human chronic myelogenous leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma) and SKLU-1 (human lung adenocarcinoma) cell lines was studied and compared with cisplatin. All tested compounds showed good activity and the aryl-chloro substituted ferrocenylthiosemicarbazones showed the best anticancer activity.
- Published
- 2014
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