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2. Beyond the Standard Model Physics at the HL-LHC and HE-LHC

Author

Vidal, X. Cid, D'Onofrio, M., Fox, P. J., Torre, R., Ulmer, K. A., Aboubrahim, A., Albert, A., Alimena, J., Allanach, B. C., Alpigiani, C., Altakach, M., Amoroso, S., Anders, J. K., Araz, J. Y., Arbey, A., Azzi, P., Babounikau, I., Baer, H., Baker, M. J., Barducci, D., Barger, V., Baron, O., Navarro, L. Barranco, Battaglia, M., Bay, A., Bhatia, D., Biswas, S., Bloch, D., Bogavac, D., Borschensky, C., Bugge, M. K., Buttazzo, D., Cacciapaglia, G., Cadamuro, L., Calandri, A., Camargo, D. A., Canepa, A., Carminati, L., Carrá, S., Montoya, C. A. Carrillo, De Oliveira, A. Carvalho Antunes, Castillo, F. L., Cavaliere, V., Cavalli, D., Cecchi, C., Celis, A., Cerri, A., Chahal, G. S., Chakraborty, A., Chekanov, S. V., Cheng, H. J., Childers, J. T., Cirelli, M., Colegrove, O., Corcella, G., Corradi, M., Costa, M. J., Covarelli, R., Dang, N. P., Deandrea, A., De Curtis, S., De la Torre, H., Rose, L. Delle, Del Re, D., Demela, A., Demers, S., Dermisek, R., De Santo, A., Deshpande, K., Dey, B., Donini, J., Duncan, A. K., Dutta, V., Escobar, C., Fanó, L., Ferretti, G., Fiaschi, J., Fischer, O., Flacke, T., Frangipane, E. D., Frank, M., Frattari, G., Frizzell, D., Fuchs, E., Fuks, B., Gabrielli, E., Gainer, J., Gao, Y., Navarro, J. E. García, Genest, M. H., Giagu, S., Giudice, G. F., Goh, J., Gouzevitch, M., Govoni, P., Greljo, A., Grohsjean, A., Gurrola, A., Gustavino, G., Guyot, C., Gwilliam, C. B., Ha, S., Haisch, U., Haller, J., Han, T., Hayden, D., Heikinheimo, M., Heintz, U., Helsens, C., Hoepfner, K., Hogan, J. M., Huitu, K., Ilten, P., Ippolito, V., Ismail, A., Iyer, A. M., Jain, Sa., Jamin, D. O., Jeanty, L., Jezo, T., Johns, W., Kalogeropoulos, A., Karancsi, J., Kats, Y., Keller, H., Khanov, A., Kieseler, J., Kim, B., Kim, M. S., Kim, Y. G., Klasen, M., Klimek, M. D., Kogler, R., Komaragiri, J. R., Krämer, M., Kubota, S., Kulesza, A. K., Kulkarni, S., Lari, T., Ledovskoy, A., Lee, G. R., Lee, L., Lee, S. W., Leonardi, R., Les, R., Lewis, I. M., Li, Q., Li, T., Lim, I. T., Lim, S. H., Lin, K., Liu, Z., Long, K., Low, M., Lunghi, E., Madaffari, D., Mahmoudi, F., Majumder, D., Malvezzi, S., Mangano, M. L., Manoni, E., Marcano, X., Mariotti, A., Marjanovic, M., Marlow, D., Camalich, J. Martin, Cuevas, P. Matorras, McCullough, M., McDonald, E. F., Guisao, J. Mejia, Mele, B., Meloni, F., Melzer-Pellmann, I. -A., Merlassino, C., Meyer, A. B., Michielin, E., Miller, A. J., Mittnacht, L., Mondal, S., Moretti, S., Mukhopadhyay, S., Nachman, B. P., Nam, K., Narain, M., Nardecchia, M., Nath, P., Navarro-González, J., Nisati, A., Nitta, T., Noel, D. L., Nojiri, M. M., Ochoa-Ricoux, J. P., Oide, H., Ojeda, M. L., Griso, S. Pagan, Cortezon, E. Palencia, Panella, O., Pani, P., Panizzi, L., Panwar, L., Park, C. B., Pazzini, J., Pedro, K., Perego, M. M., Perrozzi, L., Petersen, B. A., Pierce, A., Polesello, G., Policicchio, A., Potter, C. J., Pralavorio, P., Presilla, M., Proudfoot, J., Queiroz, F. S., Ramirez-Sanchez, G., Redigolo, D., Reimers, A., Resconi, S., Rimoldi, M., Vergara, J. C. Rivera, Rizzo, T., Rogan, C., Romeo, F., Rosten, R., Ruiz, R., Ruiz-Alvarez, J., Iglesias, J. A. Sabater, Samani, B. Safarzadeh, Sagir, S., Saito, M., Saito, S., Sala, F., Salazar, C., Savin, A., Sawada, R., Sawant, S., Schienbein, I., Schlaffer, M., Schneider, B., Schuler, S. C., Sebastiani, C. D., Sekmen, S., Selvaggi, M., Sengupta, D., Serce, H., Serodio, H., Sestini, L., Shakya, B., Haghi, B. Shams Es, Sheldon, P., Shin, S., Simonetto, F., Soffi, L., Spannowsky, M., Stupak, J., Sullivan, M. J., Sunder, M., Takahashi, Y., Tata, X., Teagle, H., Terashi, K., Tesi, A., Thamm, A., Tobioka, K., Tornambe, P., Trovato, F., Tsiakkouri, D., Ungaro, F. C., Urbano, A., Usai, E., Vanegas, N., Vaslin, L., Sierra, C. Vázquez, Vivarelli, I., Milosavljevic, M. Vranjes, Waltari, H., Wang, R., Wang, X., Weber, M. S., Weiland, C., Wielers, M., Williams, J. M., Willocq, S., Xu, D., Yagyu, K., Yazgan, E., Ye, R., Yoo, H. D., You, T., Yu, F., Della Porta, G. Zevi, Zhang, W., Zhu, C., Zhuang, X., Zobec, J., Zupan, J., and Zurita, J.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

This is the third out of five chapters of the final report [1] of the Workshop on Physics at HL-LHC, and perspectives on HE-LHC [2]. It is devoted to the study of the potential, in the search for Beyond the Standard Model (BSM) physics, of the High Luminosity (HL) phase of the LHC, defined as $3~\mathrm{ab}^{-1}$ of data taken at a centre-of-mass energy of $14~\mathrm{TeV}$, and of a possible future upgrade, the High Energy (HE) LHC, defined as $15~\mathrm{ab}^{-1}$ of data at a centre-of-mass energy of $27~\mathrm{TeV}$. We consider a large variety of new physics models, both in a simplified model fashion and in a more model-dependent one. A long list of contributions from the theory and experimental (ATLAS, CMS, LHCb) communities have been collected and merged together to give a complete, wide, and consistent view of future prospects for BSM physics at the considered colliders. On top of the usual standard candles, such as supersymmetric simplified models and resonances, considered for the evaluation of future collider potentials, this report contains results on dark matter and dark sectors, long lived particles, leptoquarks, sterile neutrinos, axion-like particles, heavy scalars, vector-like quarks, and more. Particular attention is placed, especially in the study of the HL-LHC prospects, to the detector upgrades, the assessment of the future systematic uncertainties, and new experimental techniques. The general conclusion is that the HL-LHC, on top of allowing to extend the present LHC mass and coupling reach by $20-50\%$ on most new physics scenarios, will also be able to constrain, and potentially discover, new physics that is presently unconstrained. Moreover, compared to the HL-LHC, the reach in most observables will generally more than double at the HE-LHC, which may represent a good candidate future facility for a final test of TeV-scale new physics., Comment: Report from Working Group 3 on the Physics of the HL-LHC, and Perspectives at the HE-LHC; v2: final version updated with the latest contributions and summaries; 239 pages + refs; v3: typos and character misprint in Fig. 7.2 fixed; v4: added one missing author

Published
2018

10. Stationarity-conservation laws for certain linear fractional differential equations

Author

Klimek, M.

Subjects
Mathematical Physics, 26A33
Abstract

The Leibniz rule for fractional Riemann-Liouville derivative is studied in algebra of functions defined by Laplace convolution. This algebra and the derived Leibniz rule are used in construction of explicit form of stationary-conserved currents for linear fractional differential equations. The examples of the fractional diffusion in 1+1 and the fractional diffusion in d+1 dimensions are discussed in detail. The results are generalized to the mixed fractional-differential and mixed sequential fractional-differential systems for which the stationarity-conservation laws are obtained. The derived currents are used in construction of stationary nonlocal charges., Comment: 28 pages

Published
2001
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11. Conservation laws for a class of nonlinear equations with variable coefficients on discrete and noncommutative spaces

Author

Klimek, M.

Subjects
Mathematical Physics
Abstract

The conservation laws for a class of nonlinear equations with variable coefficients on discrete and noncommutative spaces are derived. For discrete models the conserved charges are constructed explicitly. The applications of the general method include equations on quantum plane, supersymmetric equations for chiral and antichiral supermultiplets as well as auxiliary equations of integrable models - principal chiral model and various cases of nonlinear Toda lattice equations.

Published
2000

12. Local anesthetics for brain tumor resection: current perspectives

Author

Potters JW and Klimek M

Subjects
Brain tumor, craniotomy, local anesthesia, neurosurgery, scalp block, Anesthesiology, RD78.3-87.3
Abstract

Jan-Willem Potters, Markus Klimek Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands Abstract: This review summarizes the added value of local anesthetics in patients undergoing craniotomy for brain tumor resection, which is a procedure that is carried out frequently in neurosurgical practice. The procedure can be carried out under general anesthesia, sedation with local anesthesia or under local anesthesia only. Literature shows a large variation in the postoperative pain intensity ranging from no postoperative analgesia requirement in two-thirds of the patients up to a rate of 96% of the patients suffering from severe postoperative pain. The only identified causative factor predicting higher postoperative pain scores is infratentorial surgery. Postoperative analgesia can be achieved with multimodal pain management where local anesthesia is associated with lower postoperative pain intensity, reduction in opioid requirement and prevention of development of chronic pain. In awake craniotomy patients, sufficient local anesthesia is a cornerstone of the procedure. An awake craniotomy and brain tumor resection can be carried out completely under local anesthesia only. However, the use of sedative drugs is common to improve patient comfort during craniotomy and closure. Local anesthesia for craniotomy can be performed by directly blocking the six different nerves that provide the sensory innervation of the scalp, or by local infiltration of the surgical site and the placement of the pins of the Mayfield clamp. Direct nerve block has potential complications and pitfalls and is technically more challenging, but mostly requires lower total doses of the local anesthetics than the doses required in surgical-site infiltration. Due to a lack of comparative studies, there is no evidence showing superiority of one technique versus the other. Besides the use of other local anesthetics for analgesia, intravenous lidocaine administration has proven to be a safe and effective method in the prevention of coughing during emergence from general anesthesia and extubation, which is especially appreciated after brain tumor resection. Keywords: brain tumor, craniotomy, local anesthesia, neurosurgery, scalp block

Published
2018

13. Music to prevent deliriUm during neuroSurgerY (MUSYC): a single-centre, prospective randomised controlled trial

Author

Kappen, Pablo R, primary, Mos, M I, additional, Jeekel, Johannes, additional, Dirven, Clemens M F, additional, Kushner, Steven A, additional, Osse, Robert-Jan, additional, Coesmans, Michiel, additional, Poley, Marten J, additional, van Schie, Mathijs S, additional, van der Holt, Bronno, additional, Klimek, M, additional, and Vincent, Arnaud J P E, additional

Published
2023
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15. Clinical characteristics, treatment and outcomes of acute heart failure patients over 65 years of age (analysis from the OP-AHF registry)

Author

Sitkiewicz, J, primary, Rajski, R, additional, Dabrowska, K, additional, Wojcicki, K, additional, Chruscicki, D, additional, Borys, D, additional, Krzypkowska, M, additional, Pelc, M, additional, Klimek, M, additional, Malaka, E, additional, Kucharska, J, additional, Rzepiela, L, additional, Wezyk-Wylegala, N, additional, Plonka, J, additional, and Gierlotka, M, additional

Published
2023
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17. Conservation laws for linear equations on quantum Minkowski spaces

Author

Klimek, M.

Subjects
High Energy Physics - Theory
Abstract

The general, linear equations with constant coefficients on quantum Minkowski spaces are considered and the explicit formulae for their conserved currents are given. The proposed procedure can be simplified for *-invariant equations. The derived method is then applied to Klein-Gordon, Dirac and wave equations on different classes of Minkowski spaces. In the examples also symmetry operators for these equations are obtained. They include quantum deformations of classical symmetry operators as well as an additional operator connected with deformation of the Leibnitz rule in non-commutative differential calculus., Comment: 21 pages, LaTeX file

Published
1997
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28. Audit

Author

Klimek, M., Grüne, F., and Gullo, Antonino, editor

Published
2007
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46. Variation in the practice of tracheal intubation in Europe after traumatic brain injury : a prospective cohort study

Author

Gravesteijn B. Y., Sewalt C. A., Ercole A., Lecky F., Menon D., Steyerberg E. W., Maas A. I. R., Lingsma H. F., Klimek M., Akerlund C., Adams H., Amrein K., Andelic N., Andreassen L., Anke A., Audibert G., Azouvi P., Azzolini M., Bartels R., Beer R., Bellander B., Benali H., Berardino M., Beretta L., Blaabjerg M., Borgen L., Brorsson C., Buki A., Cabeleira M., Caccioppola A., Calappi E., Calvi M., Cameron P., Carbayo L., Carbonara M., Leon A., Chevallard G., Chieregato A., Citerio G., Coburn M., Coles J., Cooper J., Correia M., Cnossen M., Czeiter E., Czosnyka M., Fizelier C., DeKeyser V., Degos V., DellaCorte F., den Boogert H., Depreitere B., Dilvesi D., Dixit A., Donoghue E., Dreier J., Duliere G., Ezer E., Fabricius M., Foks K., Frisvold S., Furmanov A., Galanaud D., Gantner D., Ghuysen A., Giga L., Golubovic J., Gomez P., Grossi F., Gupta D., Haitsma I., Helbok R., Helseth E., Hutchinson P., Jankowski S., Karan M., Kolias A., Kondziella D., Koskinen L., Kovacs N., Lagares A., Laureys S., Lightfoot R., Lingsma H., Maas A., Manara A., Martino C., Marechal H., Mattern J., McFadyen C., McMahon C., Menovsky T., Mulazzi D., Muraleedharan V., Murray L., Nair N., Negru A., Nelson D., Newcombe V., Noirhomme Q., Nyiradi J., Ortolano F., Payen J., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Ples H., Pomposo I., Posti J., Puybasset L., Radoi A., Ragauskas A., Raj R., Rhodes J., Richter S., Rocka S., Roe C., Roise O., Rosenfeld J., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Sahuquillo J., Sandro O., Sakowitz O., Porras R., Schirmer-Mikalsen K., SchouRico F., Smielewski P., Sorinola A., Stamatakis E., Kowalk A., Steyerberg E., Stocchetti N., Sundstrom N., Takala R., Tamas V., Tamosuitis T., Tenovuo O., Thomas M., Tibboel D., Tolias C., Trapani T., Tudora C., Vajkoczy P., Vallance S., Valeinis E., Vamos Z., Van der Steen G., vanDijck J., van Essen T., Vanhaudenhuyse A., van Wijk R., Vargiolu A., Vega E., Vik A., Vilcinis R., Volovici V., Voormolen D., Vulekovic P., Williams G., Wolf S., Younsi A., Zeiler F., Ziverte A., Zoerle T., CENTER-TBI Collaborators, Ercole, Ari [0000-0001-8350-8093], Menon, David [0000-0002-3228-9692], Apollo - University of Cambridge Repository, Ragauskas, Arminas, Rocka, Saulius, Tamosuitis, Tomas, Vilcinis, Rimantas, „Wiley' grupė, Gravesteijn, By, Sewalt, Ca, Ercole, A, Lecky, F, Menon, D, Steyerberg, Ew, Maas, A I R, Lingsma, H F, Klimek, M (CENTER-TBI collaborators), Beretta, L, Gravesteijn, B, Sewalt, C, Steyerberg, E, Maas, A, Lingsma, H, Klimek, M, Akerlund, C, Adams, H, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Beer, R, Bellander, B, Benali, H, Berardino, M, Blaabjerg, M, Borgen, L, Brorsson, C, Buki, A, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Carbayo, L, Carbonara, M, Leon, A, Chevallard, G, Chieregato, A, Citerio, G, Coburn, M, Coles, J, Cooper, J, Correia, M, Cnossen, M, Czeiter, E, Czosnyka, M, Fizelier, C, Dekeyser, V, Degos, V, Dellacorte, F, den Boogert, H, Depreitere, B, Dilvesi, D, Dixit, A, Donoghue, E, Dreier, J, Duliere, G, Ezer, E, Fabricius, M, Foks, K, Frisvold, S, Furmanov, A, Galanaud, D, Gantner, D, Ghuysen, A, Giga, L, Golubovic, J, Gomez, P, Grossi, F, Gupta, D, Haitsma, I, Helbok, R, Helseth, E, Hutchinson, P, Jankowski, S, Karan, M, Kolias, A, Kondziella, D, Koskinen, L, Kovacs, N, Lagares, A, Laureys, S, Lightfoot, R, Manara, A, Martino, C, Marechal, H, Mattern, J, Mcfadyen, C, Mcmahon, C, Menovsky, T, Mulazzi, D, Muraleedharan, V, Murray, L, Nair, N, Negru, A, Nelson, D, Newcombe, V, Noirhomme, Q, Nyiradi, J, Ortolano, F, Payen, J, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Ples, H, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rhodes, J, Richter, S, Rocka, S, Roe, C, Roise, O, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Sahuquillo, J, Sandro, O, Sakowitz, O, Porras, R, Schirmer-Mikalsen, K, Schourico, F, Smielewski, P, Sorinola, A, Stamatakis, E, Kowalk, A, Stocchetti, N, Sundstrom, N, Takala, R, Tamas, V, Tamosuitis, T, Tenovuo, O, Thomas, M, Tibboel, D, Tolias, C, Trapani, T, Tudora, C, Vajkoczy, P, Vallance, S, Valeinis, E, Vamos, Z, Van der Steen, G, Vandijck, J, van Essen, T, Vanhaudenhuyse, A, van Wijk, R, Vargiolu, A, Vega, E, Vik, A, Vilcinis, R, Volovici, V, Voormolen, D, Vulekovic, P, Williams, G, Wolf, S, Younsi, A, Zeiler, F, Ziverte, A, Zoerle, T, Ročka, Saulius, Tamošuitis, Tomas, Anesthesiology, and Public Health

Subjects
Adult, Male, medicine.medical_specialty, Anestesi och intensivvård, Neurology, Neurologi, Traumatic brain injury, medicine.medical_treatment, Severity of Illness Index, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, Brain Injuries, Traumatic, Severity of illness, Intubation, Intratracheal, medicine, Humans, Intubation, tracheal intubation, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Aged, Anesthesiology and Intensive Care, business.industry, traumatic brain injury, Tracheal intubation, Age Factors, VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710, Middle Aged, medicine.disease, VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710, 3. Good health, Europe, Anesthesiology and Pain Medicine, guideline, practice variation, Emergency medicine, Europe, guideline, practice variation, tracheal intubation, traumatic brain injury, Female, Neurosurgery, Human medicine, business, Cohort study
Abstract

Traumatic brain injury patients frequently undergo tracheal intubation. We aimed to assess current intubation practice in Europe and identify variation in practice. We analysed data from patients with traumatic brain injury included in the prospective cohort study collaborative European neurotrauma effectiveness research in traumatic brain injury (CENTER‐TBI) in 45 centres in 16 European countries. We included patients who were transported to hospital by emergency medical services. We used mixed‐effects multinomial regression to quantify the effects on pre‐hospital or in‐hospital tracheal intubation of the following: patient characteristics; injury characteristics; centre; and trauma system characteristics. A total of 3843 patients were included. Of these, 1322 (34%) had their tracheas intubated; 839 (22%) pre‐hospital and 483 (13%) in‐hospital. The fit of the model with only patient characteristics predicting intubation was good (Nagelkerke R2 64%). The probability of tracheal intubation increased with the following: younger age; lower pre‐hospital or emergency department GCS; higher abbreviated injury scale scores (head and neck, thorax and chest, face or abdomen abbreviated injury score); and one or more unreactive pupils. The adjusted median odds ratio for intubation between two randomly chosen centres was 3.1 (95%CI 2.1–4.3) for pre‐hospital intubation, and 2.7 (95%CI 1.9–3.5) for in‐hospital intubation. Furthermore, the presence of an anaesthetist was independently associated with more pre‐hospital intubation (OR 2.9, 95%CI 1.3–6.6), in contrast to the presence of ambulance personnel who are allowed to intubate (OR 0.5, 95%CI 0.3–0.8). In conclusion, patient and injury characteristics are key drivers of tracheal intubation. Between‐centre differences were also substantial. Further studies are needed to improve the evidence base supporting recommendations for tracheal intubation. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Published
2019

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