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183 results on '"Kleinrok, Andrzej"'

2. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial

Author

Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanassche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Maria Lorenza, Muiesan, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Aleksandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martínez García, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Michael Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Davis, William Ross, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, Rich, Lisa, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, and Wang, Ji-Guang

Published
2022
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3. Ranking of diseases affecting the health-related quality of life of patients in Poland – a cross-sectional study.

Author

Krawczyk-Suszek, Marlena, Gaweł, Arkadiusz, and Kleinrok, Andrzej

Subjects
NEUROLOGICAL disorders, CARDIOVASCULAR diseases, DIGESTIVE system diseases, QUALITY of life, DISEASE incidence
Abstract

Introduction: Epidemiology of non-communicable diseases (NCDs) provides scientific evidence indicating the appearance of dysfunction and disability in patients in various aspects and, as a result, a decrease in the quality of life (QoL). The main aim of the research was to prepare a ranking of diseases determining the degree of disease incidence quality of life (HRQoL) of patients in physical and mental dimensions. Material and methods: The study was carried out in a group of 7,620 patients assigned to 13 groups of disease entities. The quality of life was assessed using the SF-36 questionnaire. The chances of a better QoL were assessed and the groups of diseases determining the individual QoL dimensions were indicated. Multi-stage, stratified random sampling was used in the study to obtain representatives in each diseases entities. Results: The worst quality of life among the 13 analysed diseases was noted among cancer patients. Patients with ENT (ear, nose, throat) diseases had the highest chance of a better QoL among the studied subjects (Mental Component Summary (MCS)-OR: 27.4; Physical Component Summary (PCS)- OR: 27.9). Diseases such as cancers, diseases of the nervous system and cardiovascular diseases determined the lowest QoL in terms of MCS, PCS and ILQ (Index of Life Quality). Additionally, lower QoL in the MCS dimension was also affected by diabetes, diseases of the digestive and respiratory systems. Conclusions: Cancer, cardiovascular disease and diseases of the nervous system are the disease entities correlated with poorer quality of life. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Comparison of reorganized versus unaltered cardiology departments during the COVID-19 era: a subanalysis of the COV-HF-SIRIO 6 study

Author

Ostrowska, Małgorzata, primary, Kasprzak, Michał, additional, Stolarek, Wioleta, additional, Grzelakowska, Klaudyna, additional, Kryś, Jacek, additional, Kubica, Aldona, additional, Adamski, Piotr, additional, Podhajski, Przemysław, additional, Navarese, Eliano Pio, additional, Anielska-Michalak, Edyta, additional, Matuszewska-Brycht, Oliwia, additional, Curzytek, Andrzej, additional, Dudek, Aneta, additional, Gromadziński, Leszek, additional, Grzelakowski, Paweł, additional, Kamiński, Leszek, additional, Kleinrok, Andrzej, additional, Kostkiewicz, Marcin, additional, Koziński, Marek, additional, Król, Paweł, additional, Kulawik, Tomasz, additional, Minczew, Gleb, additional, Mindykowski, Marcin, additional, Pawlak, Agnieszka, additional, Prokopczuk, Janusz, additional, Skonieczny, Grzegorz, additional, Sobkowicz, Bożena, additional, Sowiński, Sergiusz, additional, Stankala, Sebastian, additional, Szymański, Paweł, additional, Wester, Andrzej, additional, Wilczewski, Przemysław, additional, Bartuś, Stanisław, additional, Budaj, Andrzej, additional, Gajda, Robert, additional, Gąsior, Mariusz, additional, Gruchała, Marcin, additional, Drożdż, Jarosław, additional, Jaguszewski, Miłosz, additional, Jankowski, Piotr, additional, Legutko, Jacek, additional, Lesiak, Maciej, additional, Leszek, Przemysław, additional, Mitkowski, Przemysław, additional, Nessler, Jadwiga, additional, Tomaszuk-Kazberuk, Anna, additional, Tycińska, Agnieszka, additional, Zdrojewski, Tomasz, additional, Kaźmierczak, Jarosław, additional, and Kubica, Jacek, additional

Published
2023
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6. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial

Author

Schlaich, Markus P, primary, Bellet, Marc, additional, Weber, Michael A, additional, Danaietash, Parisa, additional, Bakris, George L, additional, Flack, John M, additional, Dreier, Roland F, additional, Sassi-Sayadi, Mouna, additional, Haskell, Lloyd P, additional, Narkiewicz, Krzysztof, additional, Wang, Ji-Guang, additional, Reid, Christopher, additional, Schlaich, Markus, additional, Katz, Ivor, additional, Ajani, Andrew, additional, Biswas, Sinjini, additional, Esler, Murray, additional, Elder, Grahame, additional, Roger, Simon, additional, Colquhoun, David, additional, Mooney, John, additional, De Backer, Tine, additional, Persu, Alexandre, additional, Chaumont, Martin, additional, Krzesinski, Jean-Marie, additional, Vanassche, Thomas, additional, Girard, Ginette, additional, Pliamm, Lew, additional, Schiffrin, Ernesto, additional, Merali, Fatima, additional, Dresser, George, additional, Vallee, Michel, additional, Jolly, Shivinder, additional, Chow, Stephen, additional, Wang, Jiguang, additional, Mu, Jianjun, additional, Yu, Jing, additional, Yuan, Hong, additional, Feng, Yingqing, additional, Zhang, Xin, additional, Xie, Jianhong, additional, Lin, Ling, additional, Soucek, Miroslav, additional, Widimsky, Jiri, additional, Cifkova, Renata, additional, Vaclavik, Jan, additional, Ullrych, Martin, additional, Lukac, Martin, additional, Rychlik, Ivan, additional, Guldager Lauridsen, Thomas, additional, Kantola, Ilkka, additional, Taurio, Jyrki, additional, Ukkola, Olavi, additional, Ormezzano, Olivier, additional, Gosse, Philippe, additional, Azizi, Michel, additional, Courand, Pierre-Yves, additional, Delsart, Pascal, additional, Tartiere, Jean Michel, additional, Mahfoud, Felix, additional, Schmieder, Roland, additional, Stegbauer, Johannes, additional, Lurz, Philipp, additional, Koziolek, Michael, additional, Ott, Christian, additional, Toursarkissian, Nicole, additional, Tsioufis, Konstantinos, additional, Kyfnidis, Konstantinos, additional, Manolis, Athanasios, additional, Patsilinakos, Sotirios, additional, Zebekakis, Pantelis, additional, Karavidas, Apostolos, additional, Denes, Pall, additional, Bezzegh, Katalin, additional, Zsom, Marianna, additional, Kovacs, Laszlo, additional, Sharabi, Yehonatan, additional, Elias, Mazen, additional, Sukholutsky, Ivetta, additional, Yosefy, Chaim, additional, Kenis, Irina, additional, Atar, Shaul, additional, Volpe, Massimo, additional, Maria Lorenza, Muiesan, additional, Taddei, Stefano, additional, Grassi, Guido, additional, Veglio, Franco, additional, Son, Jung Woo, additional, Kim, Jang-Young, additional, Park, Joong-Il, additional, Lee, Chang Hoon, additional, Lee, Hae-Young, additional, Raugaliene, Rasa, additional, Marcinkeviciene, Jolanta Elena, additional, Kavaliauskiene, Roma, additional, Deinum, Jaap, additional, Kroon, Abraham, additional, van den Born, Bert-Jan, additional, Januszewicz, Andrzej, additional, Tykarski, Andrzej, additional, Walczewska, Jolanta, additional, Gaciong, Zbigniew, additional, Wiecek, Andrzej, additional, Chrostowska, Marzena, additional, Kleinrok, Andrzej, additional, Krekora, Jan, additional, Kania, Grzegorz, additional, Podrazka-Szczepaniak, Anna, additional, Golawski, Cezary, additional, Podziewski, Maciej, additional, Kaczmarek, Barbara, additional, Skoczylas, Grzegorz, additional, Wilkolaski, Andrzej, additional, Wozniak, Iwona, additional, Janik-Palazzolo, Marzena, additional, Rewerska, Barbara, additional, Konradi, Aleksandra, additional, Shvarts, Yuriy, additional, Pecherina, Tamara, additional, Nikolaev, Konstantin, additional, Liudmila, Gapon, additional, Orlikova, Olga, additional, Mordovin, Viktor, additional, Petrochenkova, Natalia, additional, Kamalov, Gadel, additional, Kosmacheva, Elena, additional, Tyrenko, Vadim, additional, Gorbunov, Vladimir, additional, Obrezan, Andrey, additional, Supryadkina, Tatiana, additional, Ler, Irina, additional, Kotenko, Oleg, additional, Kuzin, Anatoly, additional, Martínez García, Fernando, additional, Redon, Josep, additional, Oliveras, Anna, additional, Beltran Romero, Luis, additional, Shatylo, Valerii, additional, Rudenko, Leonid, additional, Bazylevych, Andriy, additional, Rudyk, Yurii, additional, Karpenko, Oleksandr, additional, Stanislavchuk, Mykola, additional, Tseluyko, Vira, additional, Kushnir, Mykola, additional, Asanov, Ervin, additional, Sirenko, Yuriy, additional, Yagensky, Andriy, additional, Collier, David, additional, Gupta, Pankaj, additional, Webb, David, additional, MacLeod, Mary, additional, McLay, James, additional, Peace, Aaron, additional, Arora, Samir, additional, Buchanan, Patricia, additional, Harris, Robert, additional, Degarmo, Ronald, additional, Guillen, Mario, additional, Karns, Adam, additional, Neutel, Joel, additional, Paliwal, Yogesh, additional, Pettis, Karlton, additional, Toth, Phillip D., additional, Wayne, Jeffrey M., additional, Butcher, Michael Bain, additional, Diller, Phillip M., additional, Oparil, Suzanne, additional, Calhoun, David, additional, Brautigam, Donald, additional, Flack, John, additional, Goldman, Jesse M., additional, Rashidi, Arash, additional, Aslam, Nabeel, additional, Haley, William, additional, Andrawis, Nabil, additional, Lang, Brian, additional, Miller, Randy, additional, Powell, James, additional, Dewhurst, Robert, additional, Pritchard, James, additional, Khanna, Dinesh, additional, Tang, Dennis, additional, Gabra, Nashwa, additional, Park, Jean, additional, Jones, Conigliaro, additional, Scott, Cranford, additional, Luna, Blanca, additional, Mussaji, Murtaza, additional, Bhagwat, Ravi, additional, Bauer, Michael, additional, McGinty, John, additional, Nambiar, Rajesh, additional, Sangrigoli, Renee, additional, Davis, William Ross, additional, Eaves, William, additional, McGrew, Frank, additional, Awad, Ahmed, additional, Bolster, Eric, additional, Scott, David, additional, Kalirao, Paramjit, additional, Dabel, Pascal, additional, Calhoun, Wesley, additional, Gouge, Steven, additional, Warren, Mark, additional, Lawrence, Mary Katherine, additional, Jamal, Aamir, additional, El-Shahawy, Mohamed, additional, Mercado, Carlos, additional, Kumar, Jayant, additional, Velasquez-Mieyer, Pedro, additional, Busch, Robert, additional, Lewis, Todd, additional, and Rich, Lisa, additional

Published
2022
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7. Dutogliptin in Combination with Filgrastim in Early Recovery Post-Myocardial Infarction—The REC-DUT-002 Trial

Author

von Lewinski, Dirk, primary, Benedikt, Martin, additional, Alber, Hannes, additional, Debrauwere, Jan, additional, Smits, Pieter C., additional, Édes, István, additional, Kiss, Róbert Gábor, additional, Merkely, Béla, additional, Nagy, Gergely Gyorgy, additional, Ptaszynski, Pawel, additional, Zarebinski, Maciej, additional, Kubica, Jacek, additional, Kleinrok, Andrzej, additional, Coats, Andrew J. S., additional, and Wallner, Markus, additional

Published
2022
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8. Longer Hospitalizations and Higher In-Hospital Mortality for Acute Heart Failure during the COVID-19 Pandemic in Larger vs. Smaller Cardiology Departments: Subanalysis of the COV-HF-SIRIO 6 Multicenter Study

Author

Ostrowska, Małgorzata, primary, Kasprzak, Michał, primary, Stolarek, Wioleta, primary, Grzelakowska, Klaudyna, primary, Kryś, Jacek, primary, Kubica, Aldona, primary, Adamski, Piotr, primary, Podhajski, Przemysław, primary, Navarese, Eliano Pio, primary, Anielska-Michalak, Edyta, primary, Matuszewska-Brycht, Oliwia, primary, Curzytek, Andrzej, primary, Dudek, Aneta, primary, Gromadziński, Leszek, primary, Grzelakowski, Paweł, primary, Kamiński, Leszek, primary, Kleinrok, Andrzej, primary, Kostkiewicz, Marcin, primary, Koziński, Marek, primary, Król, Paweł, primary, Kulawik, Tomasz, primary, Minczew, Gleb, primary, Mindykowski, Marcin, primary, Pawlak, Agnieszka, primary, Prokopczuk, Janusz, primary, Skonieczny, Grzegorz, primary, Sobkowicz, Bożena, primary, Sowiński, Sergiusz, primary, Stankala, Sebastian, primary, Szymański, Paweł, primary, Wester, Andrzej, primary, Wilczewski, Przemysław, primary, Bartuś, Stanisław, primary, Budaj, Andrzej, primary, Gajda, Robert, primary, Gąsior, Mariusz, primary, Gruchała, Marcin, primary, Drożdż, Jarosław, primary, Jaguszewski, Miłosz, primary, Jankowski, Piotr, primary, Legutko, Jacek, primary, Lesiak, Maciej, primary, Leszek, Przemysław, primary, Mitkowski, Przemysław, primary, Nessler, Jadwiga, primary, Tomaszuk-Kazberuk, Anna, primary, Tycińska, Agnieszka, primary, Zdrojewski, Tomasz, primary, Kaźmierczak, Jarosław, primary, and Kubica, Jacek, primary

Published
2022
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9. Pre-hospital treatment of patients with acute coronary syndrome: Recommendations for medical emergency teams. Expert position update 2022

Author

Kubica, Jacek, primary, Adamski, Piotr, additional, Ładny, Jerzy R., additional, Kaźmierczak, Jarosław, additional, Fabiszak, Tomasz, additional, Filipiak, Krzysztof J., additional, Gajda, Robert, additional, Gąsior, Mariusz, additional, Gąsior, Zbigniew, additional, Gil, Robert, additional, Gorący, Jarosław, additional, Grajek, Stefan, additional, Gromadziński, Leszek, additional, Gruchała, Marcin, additional, Grześk, Grzegorz, additional, Hoffman, Piotr, additional, Jaguszewski, Miłosz J., additional, Janion, Marianna, additional, Jankowski, Piotr, additional, Kalarus, Zbigniew, additional, Kasprzak, Jarosław D., additional, Kleinrok, Andrzej, additional, Kochman, Wacław, additional, Kubica, Aldona, additional, Kuliczkowski, Wiktor, additional, Legutko, Jacek, additional, Lesiak, Maciej, additional, Nadolny, Klaudiusz, additional, Navarese, Eliano P., additional, Niezgoda, Piotr, additional, Ostrowska, Małgorzata, additional, Paciorek, Przemysław, additional, Siller-Matula, Jolanta, additional, Szarpak, Łukasz, additional, Timler, Dariusz, additional, Witkowski, Adam, additional, Wojakowski, Wojciech, additional, Wysokiński, Andrzej, additional, and Zielińska, Marzenna, additional

Published
2022
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10. Low-dose ticagrelor with or without acetylsalicylic acid in patients with acute coronary syndrome : Rationale and design of the ELECTRA-SIRIO 2 trial

Author

Kubica, Jacek, Adamski, Piotr, Gorog, Diana A., Kubica, Aldona, Jilma, Bernd, Budaj, Andrzej, Siller-Matula, Jolanta M., Gurbel, Paul A., Alexopoulos, Dimitrios, Badariene, Jolita, Dabrowski, Pawel, Dudek, Dariusz, Giannitsis, Evangelos, Horszczaruk, Grzegorz, Jaguszewski, Milosz J., James, Stefan, Jeong, Young-Hoon, Kryjak, Michal, Niezgoda, Piotr, Ostrowska, Malgorzata, Patti, Giuseppe, Romanek, Janusz, Di Somma, Salvatore, Specchia, Giuseppe, Tantry, Udaya, Gasior, Mariusz, Tycinska, Agnieszka, Wojakowski, Wojciech, Buszko, Katarzyna, Gil, Robert, Gruchala, Marcin, Kasprzak, Jaroslaw, Kleinrok, Andrzej, Legutko, Jacek, Lesiak, Maciej, Navarese, Eliano P., Kubica, Jacek, Adamski, Piotr, Gorog, Diana A., Kubica, Aldona, Jilma, Bernd, Budaj, Andrzej, Siller-Matula, Jolanta M., Gurbel, Paul A., Alexopoulos, Dimitrios, Badariene, Jolita, Dabrowski, Pawel, Dudek, Dariusz, Giannitsis, Evangelos, Horszczaruk, Grzegorz, Jaguszewski, Milosz J., James, Stefan, Jeong, Young-Hoon, Kryjak, Michal, Niezgoda, Piotr, Ostrowska, Malgorzata, Patti, Giuseppe, Romanek, Janusz, Di Somma, Salvatore, Specchia, Giuseppe, Tantry, Udaya, Gasior, Mariusz, Tycinska, Agnieszka, Wojakowski, Wojciech, Buszko, Katarzyna, Gil, Robert, Gruchala, Marcin, Kasprzak, Jaroslaw, Kleinrok, Andrzej, Legutko, Jacek, Lesiak, Maciej, and Navarese, Eliano P.

Published
2022
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11. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial

Author

Schlaich, M, Bellet, M, Weber, M, Danaietash, P, Bakris, G, Flack, J, Dreier, R, Sassi-Sayadi, M, Haskell, L, Narkiewicz, K, Wang, J, Reid, C, Katz, I, Ajani, A, Biswas, S, Esler, M, Elder, G, Roger, S, Colquhoun, D, Mooney, J, De Backer, T, Persu, A, Chaumont, M, Krzesinski, J, Vanabsche, T, Girard, G, Pliamm, L, Schiffrin, E, Merali, F, Dresser, G, Vallee, M, Jolly, S, Chow, S, Mu, J, Yu, J, Yuan, H, Feng, Y, Zhang, X, Xie, J, Lin, L, Soucek, M, Widimsky, J, Cifkova, R, Vaclavik, J, Ullrych, M, Lukac, M, Rychlik, I, Guldager Lauridsen, T, Kantola, I, Taurio, J, Ukkola, O, Ormezzano, O, Gosse, P, Azizi, M, Courand, P, Delsart, P, Tartiere, J, Mahfoud, F, Schmieder, R, Stegbauer, J, Lurz, P, Koziolek, M, Ott, C, Toursarkissian, N, Tsioufis, K, Kyfnidis, K, Manolis, A, Patsilinakos, S, Zebekakis, P, Karavidas, A, Denes, P, Bezzegh, K, Zsom, M, Kovacs, L, Sharabi, Y, Elias, M, Sukholutsky, I, Yosefy, C, Kenis, I, Atar, S, Volpe, M, Lorenza, M, Taddei, S, Grassi, G, Veglio, F, Son, J, Kim, J, Park, J, Lee, C, Lee, H, Raugaliene, R, Marcinkeviciene, J, Kavaliauskiene, R, Deinum, J, Kroon, A, van den Born, B, Januszewicz, A, Tykarski, A, Walczewska, J, Gaciong, Z, Wiecek, A, Chrostowska, M, Kleinrok, A, Krekora, J, Kania, G, Podrazka-Szczepaniak, A, Golawski, C, Podziewski, M, Kaczmarek, B, Skoczylas, G, Wilkolaski, A, Wozniak, I, Janik-Palazzolo, M, Rewerska, B, Konradi, A, Shvarts, Y, Pecherina, T, Nikolaev, K, Liudmila, G, Orlikova, O, Mordovin, V, Petrochenkova, N, Kamalov, G, Kosmacheva, E, Tyrenko, V, Gorbunov, V, Obrezan, A, Supryadkina, T, Ler, I, Kotenko, O, Kuzin, A, Martinez, F, Redon, J, Oliveras, A, Beltran Romero, L, Shatylo, V, Rudenko, L, Bazylevych, A, Rudyk, Y, Karpenko, O, Stanislavchuk, M, Tseluyko, V, Kushnir, M, Asanov, E, Sirenko, Y, Yagensky, A, Collier, D, Gupta, P, Webb, D, Macleod, M, Mclay, J, Peace, A, Arora, S, Buchanan, P, Harris, R, Degarmo, R, Guillen, M, Karns, A, Neutel, J, Paliwal, Y, Pettis, K, Toth, P, Wayne, J, Butcher, B, Diller, P, Oparil, S, Calhoun, D, Brautigam, D, Goldman, J, Rashidi, A, Aslam, N, Haley, W, Andrawis, N, Lang, B, Miller, R, Powell, J, Dewhurst, R, Pritchard, J, Khanna, D, Tang, D, Gabra, N, Jones, C, Scott, C, Luna, B, Mussaji, M, Bhagwat, R, Bauer, M, Mcginty, J, Nambiar, R, Sangrigoli, R, Ross Davis, W, Eaves, W, Mcgrew, F, Awad, A, Bolster, E, Scott, D, Kalirao, P, Dabel, P, Calhoun, W, Gouge, S, Warren, M, Lawrence, M, Jamal, A, El-Shahawy, M, Mercado, C, Kumar, J, Velasquez-Mieyer, P, Busch, R, Lewis, T, Rich, L, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, Wang, Ji-Guang, Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanabsche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Lorenza, Muiesan Maria, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Alexandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martinez, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriiy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Ross Davis, William, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, Rich, Lisa, Schlaich, M, Bellet, M, Weber, M, Danaietash, P, Bakris, G, Flack, J, Dreier, R, Sassi-Sayadi, M, Haskell, L, Narkiewicz, K, Wang, J, Reid, C, Katz, I, Ajani, A, Biswas, S, Esler, M, Elder, G, Roger, S, Colquhoun, D, Mooney, J, De Backer, T, Persu, A, Chaumont, M, Krzesinski, J, Vanabsche, T, Girard, G, Pliamm, L, Schiffrin, E, Merali, F, Dresser, G, Vallee, M, Jolly, S, Chow, S, Mu, J, Yu, J, Yuan, H, Feng, Y, Zhang, X, Xie, J, Lin, L, Soucek, M, Widimsky, J, Cifkova, R, Vaclavik, J, Ullrych, M, Lukac, M, Rychlik, I, Guldager Lauridsen, T, Kantola, I, Taurio, J, Ukkola, O, Ormezzano, O, Gosse, P, Azizi, M, Courand, P, Delsart, P, Tartiere, J, Mahfoud, F, Schmieder, R, Stegbauer, J, Lurz, P, Koziolek, M, Ott, C, Toursarkissian, N, Tsioufis, K, Kyfnidis, K, Manolis, A, Patsilinakos, S, Zebekakis, P, Karavidas, A, Denes, P, Bezzegh, K, Zsom, M, Kovacs, L, Sharabi, Y, Elias, M, Sukholutsky, I, Yosefy, C, Kenis, I, Atar, S, Volpe, M, Lorenza, M, Taddei, S, Grassi, G, Veglio, F, Son, J, Kim, J, Park, J, Lee, C, Lee, H, Raugaliene, R, Marcinkeviciene, J, Kavaliauskiene, R, Deinum, J, Kroon, A, van den Born, B, Januszewicz, A, Tykarski, A, Walczewska, J, Gaciong, Z, Wiecek, A, Chrostowska, M, Kleinrok, A, Krekora, J, Kania, G, Podrazka-Szczepaniak, A, Golawski, C, Podziewski, M, Kaczmarek, B, Skoczylas, G, Wilkolaski, A, Wozniak, I, Janik-Palazzolo, M, Rewerska, B, Konradi, A, Shvarts, Y, Pecherina, T, Nikolaev, K, Liudmila, G, Orlikova, O, Mordovin, V, Petrochenkova, N, Kamalov, G, Kosmacheva, E, Tyrenko, V, Gorbunov, V, Obrezan, A, Supryadkina, T, Ler, I, Kotenko, O, Kuzin, A, Martinez, F, Redon, J, Oliveras, A, Beltran Romero, L, Shatylo, V, Rudenko, L, Bazylevych, A, Rudyk, Y, Karpenko, O, Stanislavchuk, M, Tseluyko, V, Kushnir, M, Asanov, E, Sirenko, Y, Yagensky, A, Collier, D, Gupta, P, Webb, D, Macleod, M, Mclay, J, Peace, A, Arora, S, Buchanan, P, Harris, R, Degarmo, R, Guillen, M, Karns, A, Neutel, J, Paliwal, Y, Pettis, K, Toth, P, Wayne, J, Butcher, B, Diller, P, Oparil, S, Calhoun, D, Brautigam, D, Goldman, J, Rashidi, A, Aslam, N, Haley, W, Andrawis, N, Lang, B, Miller, R, Powell, J, Dewhurst, R, Pritchard, J, Khanna, D, Tang, D, Gabra, N, Jones, C, Scott, C, Luna, B, Mussaji, M, Bhagwat, R, Bauer, M, Mcginty, J, Nambiar, R, Sangrigoli, R, Ross Davis, W, Eaves, W, Mcgrew, F, Awad, A, Bolster, E, Scott, D, Kalirao, P, Dabel, P, Calhoun, W, Gouge, S, Warren, M, Lawrence, M, Jamal, A, El-Shahawy, M, Mercado, C, Kumar, J, Velasquez-Mieyer, P, Busch, R, Lewis, T, Rich, L, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, Wang, Ji-Guang, Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanabsche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Lorenza, Muiesan Maria, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Alexandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martinez, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriiy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Ross Davis, William, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, and Rich, Lisa

Abstract

Background: Resistant hypertension is associated with increased cardiovascular risk. The endothelin pathway has been implicated in the pathogenesis of hypertension, but it is currently not targeted therapeutically, thereby leaving this relevant pathophysiological pathway unopposed with currently available drugs. The aim of the study was to assess the blood pressure lowering efficacy of the dual endothelin antagonist aprocitentan in patients with resistant hypertension. Methods: PRECISION was a multicentre, blinded, randomised, parallel-group, phase 3 study, which was done in hospitals or research centres in Europe, North America, Asia, and Australia. Patients were eligible for randomisation if their sitting systolic blood pressure was 140 mm Hg or higher despite taking standardised background therapy consisting of three antihypertensive drugs, including a diuretic. The study consisted of three sequential parts: part 1 was the 4-week double-blind, randomised, and placebo-controlled part, in which patients received aprocitentan 12·5 mg, aprocitentan 25 mg, or placebo in a 1:1:1 ratio; part 2 was a 32-week single (patient)-blind part, in which all patients received aprocitentan 25 mg; and part 3 was a 12-week double-blind, randomised, and placebo-controlled withdrawal part, in which patients were re-randomised to aprocitentan 25 mg or placebo in a 1:1 ratio. The primary and key secondary endpoints were changes in unattended office systolic blood pressure from baseline to week 4 and from withdrawal baseline to week 40, respectively. Secondary endpoints included 24-h ambulatory blood pressure changes. The study is registered on ClinicalTrials.gov, NCT03541174. Findings: The PRECISION study was done from June 18, 2018, to April 25, 2022. 1965 individuals were screened and 730 were randomly assigned. Of these 730 patients, 704 (96%) completed part 1 of the study; of these, 613 (87%) completed part 2 and, of these, 577 (94%) completed part 3 of the study. The least square m

Published
2022

14. Low-dose ticagrelor with or without acetylsalicylic acid in patients with acute coronary syndrome: Rationale and design of the ELECTRA-SIRIO 2 trial

Author

Kubica, Jacek, primary, Adamski, Piotr, additional, Gorog, Diana A., additional, Kubica, Aldona, additional, Jilma, Bernd, additional, Budaj, Andrzej, additional, Siller-Matula, Jolanta M., additional, Gurbel, Paul A., additional, Alexopoulos, Dimitrios, additional, Badarienė, Jolita, additional, Dąbrowski, Paweł, additional, Dudek, Dariusz, additional, Giannitsis, Evangelos, additional, Horszczaruk, Grzegorz, additional, Jaguszewski, Miłosz J., additional, James, Stefan, additional, Jeong, Young-Hoon, additional, Kryjak, Michał, additional, Niezgoda, Piotr, additional, Ostrowska, Małgorzata, additional, Patti, Giuseppe, additional, Romanek, Janusz, additional, Di Somma, Salvatore, additional, Specchia, Giuseppe, additional, Tantry, Udaya, additional, Gąsior, Mariusz, additional, Tycińska, Agnieszka, additional, Wojakowski, Wojciech, additional, Buszko, Katarzyna, additional, Gil, Robert, additional, Gruchała, Marcin, additional, Kasprzak, Jarosław, additional, Kleinrok, Andrzej, additional, Legutko, Jacek, additional, Lesiak, Maciej, additional, and Navarese, Eliano P., additional

Published
2022
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16. Ischemic Events Occur Early in Patients Undergoing Percutaneous Coronary Intervention and Are Reduced With Cangrelor: Findings From CHAMPION PHOENIX

Author

Cavender, Matthew A., primary, Harrington, Robert A., additional, Stone, Gregg W., additional, Steg, Ph. Gabriel, additional, Gibson, C. Michael, additional, Hamm, Christian W., additional, Price, Matthew J., additional, Lopes, Renato D., additional, Leonardi, Sergio, additional, Deliargyris, Efthymios N., additional, Prats, Jayne, additional, Mahaffey, Kenneth W., additional, White, Harvey D., additional, Bhatt, Deepak L., additional, Huber, Kurt, additional, Lima, Valter C., additional, Jorgova-Makedonska, Julia B., additional, Widimský, Petr, additional, Kobulia, Bondo, additional, Radke, Peter W., additional, Bramucci, Ezio, additional, Witkowski, Adam, additional, Shlyakhto, Evgeny, additional, Van de Werf, Frans, additional, Faxon, David P., additional, Ohman, E. Magnus, additional, Verheugt, Freek W.A., additional, Weaver, W. Douglas, additional, Tijssen, Jan G.P., additional, Wilson, Matthew, additional, Mangum, Stacey, additional, Melloni, Chiara, additional, Brennan, Matthew J., additional, Tricoci, Pierluigi, additional, Harrison, Robert, additional, Barros, Pedro, additional, Armaganijan, Luciana, additional, Anderson, Monique, additional, Bagai, Akshay, additional, Généreux, Philippe, additional, Brener, Sorin J., additional, LaSalle, Laura, additional, Benzer, Werner, additional, Delle-Karth, Georg, additional, Leisch, Franz, additional, Abdalla Saad, Jamil, additional, Abizaid, Alexandre, additional, Augusto Formiga Areas, Carlos, additional, Ribeiro, Expedito E., additional, Rossi Dos Santos, Fabio, additional, Tadeu Tumelero, Rogerio, additional, Vieira Botelho, Roberto, additional, Atzev, Borislav, additional, Boichev, Boicho, additional, Grigorov, Georgi, additional, Penkov, Nikolay, additional, Petrov, Ivo, additional, Zehirov, Boris, additional, Cervinka, Pavel, additional, Coufal, Zdenek, additional, Hajek, Petr, additional, Horak, David, additional, Kala, Petr, additional, Kmonicek, Petr, additional, Kocka, Viktor, additional, Mrozek, Jan, additional, Simek, Stanislav, additional, Sitar, Jan, additional, Stasek, Josef, additional, Tousek, Frantisek, additional, Chapidze, Gulnara, additional, Emukhvari, Nodar, additional, Khabeishvili, George, additional, Mamatsashvili, Merab, additional, Shaburishvili, Tamaz, additional, Behrens, Steffen, additional, Darius, Harald, additional, Dissmann, Martin, additional, Fichtlscherer, Stephan, additional, Franz, Wolfgang, additional, Geisler, Tobias, additional, Genth-Zotz, Sabine, additional, Goldmann, Britta, additional, Heuer, Hubertus, additional, Hoffmann, Stefan, additional, Mugge, Andreas, additional, Poerner, Tudor, additional, Radke, Peter, additional, Richardt, Gert, additional, Stellbrink, Christoph, additional, Werner, Nikos, additional, De Servi, Stefano, additional, Galasso, Gennaro, additional, Menozzi, Alberto, additional, Musumeci, Giuseppe, additional, Picchi, Andrea, additional, Presbitero, Patrizia, additional, Devlin, Gerard, additional, Sasse, Alexander, additional, Scott, Douglas, additional, Stewart, Ralph, additional, Andrzej, Szyszka, additional, Dubaniewicz, Witold, additional, Gasior, Zbigniew, additional, Kasprzak, Jaroslaw, additional, Kleinrok, Andrzej, additional, Kornacewicz-Jach, Zdzislawa, additional, Rynkiewicz, Andrzej, additional, Sosnowski, Cezary, additional, Targonski, Radoslaw, additional, Trebacz, Jaroslaw, additional, Zinka, Elzbieta, additional, Barbarash, Olga, additional, Dovgalevsky, Yakov, additional, Gordeev, Ivan, additional, Kalinina, Svetlana, additional, Kosmachova, Elena, additional, Markov, Valentin, additional, Pavlov, Prokhor, additional, Shalaev, Sergey, additional, Shogenov, Zaur, additional, Sukmanova, Irina, additional, Vasilieva, Elena, additional, Yakovlev, Alexey, additional, Boonbaichaiyapruck, Sarana, additional, Chamnarnphol, Noppadol, additional, Kaewsuwanna, Pinij, additional, Kuanprasert, Srun, additional, Piyayotai, Dilok, additional, Amine, Maged, additional, Angiolillo, Dominick, additional, Arif, Imran, additional, Blankenship, James, additional, Brilakis, Emmanouil, additional, Chan, Michael, additional, Cinderella, Joseph, additional, Davis, Brent, additional, Devireddy, Chandanreddy, additional, Dorogy, Mark, additional, Douglas, John, additional, Ferrier, Norman, additional, Fisher, Daniel, additional, Foster, Robert, additional, French, William, additional, Galla, John, additional, Gimple, Lawrence, additional, Gogia, Harinder, additional, Gogo, Prospero, additional, Gollapudi, Raghava, additional, Gruberg, Luis, additional, Hermiller, James, additional, Heuser, Richard, additional, Iwaoka, Robert, additional, Jafar, Zubair, additional, Kimmelstiel, Carey, additional, Kinlay, Scott, additional, Leggett, James, additional, Leimgruber, Pierre, additional, Letts, Dustin, additional, Lipsitt, Michael, additional, Low, Reginald, additional, Martinez-Arraras, Joaquin, additional, Mayhew, Marc, additional, McLaurin, Brent, additional, McWhirter, Paul, additional, Mirza, Ayoub, additional, Negus, Brian, additional, Nygaard, Thomas, additional, O’Riordan, William, additional, Paulus, Richard, additional, Petersen, John, additional, Picon, Hector, additional, Picone, Mark, additional, Rivera, Ernesto, additional, Rizik, David, additional, Rodriguez, Arsenio, additional, Saucedo, Jorge, additional, Scott, J. Christopher, additional, Sethi, Virender, additional, Shroff, Adhir, additional, Siegel, Craig, additional, Spriggs, Douglas, additional, Steinberg, Daniel, additional, Stillabower, Michael, additional, Stuckey, Thomas, additional, Suarez, Jose, additional, Tauth, Jeffrey, additional, Temizer, Dogan, additional, Vidovich, Mladen, additional, Voeltz, Michele, additional, Waltman, Jonathan, additional, and Wilensky, Michael, additional

Published
2021
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17. Anticoagulation for Atrial Fibrillation in Acute Coronary Syndrome Survivors Reduces Major Cardiovascular Events and Mortality.

Author

Pyka, Łukasz, Hudzik, Bartosz, Bartuś, Stanisław, Buszman, Paweł, Gierlotka, Marek, Wojakowski, Wojciech, Hiczkiewicz, Jarosław, Kleinrok, Andrzej, Skrzypek, Michał, Kuliczkowski, Wiktor, and Gąsior, Mariusz

Subjects
ACUTE coronary syndrome, ATRIAL fibrillation, ANTICOAGULANTS, MYOCARDIAL infarction, PROPENSITY score matching, ISCHEMIC stroke
Abstract

Introduction: The prevalence of atrial fibrillation (AF) in acute coronary syndrome (ACS) patients is increasing. Data on outcomes of anticoagulation in ACS patients with AF are lacking. Objectives: The aim of our study was to investigate the prevalence of stroke, myocardial infarction, bleeding complications, and all-cause mortality in this population. Patients and methods: PL-ACS and AMI-PL registries gather an all-comer population of ACS patients in Poland, exceeding half a million records. We have selected ACS survivors with concomitant AF on admission, divided them into subgroups with regard to the administered anticoagulation, and followed up with them for a 12-month period (n=13,973). Subsequently, groups were propensity score matched for age, sex, ejection fraction, diabetes, heart failure, renal impairment, and type of ACS. Results: The study population was divided with regard to the administration of anticoagulation. Anticoagulation was prescribed in 2,466 patients (17.6%). The (D)OAC+ patients were younger; however, comorbidities were more prevalent in this group. The 12-month follow-up showed that the (D)OAC+ patients had significantly lower rates of all-cause mortality, myocardial infarction, and ischemic stroke, with no significant increase in bleeding events. After matching, the study groups consisted of 2,194 patients each and showed no differences in baseline characteristics. The outcomes of the 12-month observation were similar to the findings before matching. Conclusions: This all-comer national registry analysis shows that the use of guideline-recommended therapy and anticoagulation in ACS survivors with AF is associated with a lower rate of all-cause mortality, recurrent myocardial infarction, and ischemic stroke. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Impact of COVID‐19 pandemic on acute heart failure admissions and mortality: a multicentre study (COV‐HF‐SIRIO 6 study)

Author

Kubica, Jacek, primary, Ostrowska, Małgorzata, additional, Stolarek, Wioleta, additional, Kasprzak, Michał, additional, Grzelakowska, Klaudyna, additional, Kryś, Jacek, additional, Kubica, Aldona, additional, Adamski, Piotr, additional, Podhajski, Przemysław, additional, Navarese, Eliano Pio, additional, Anielska‐Michalak, Edyta, additional, Brycht, Oliwia, additional, Curzytek, Andrzej, additional, Dudek, Aneta, additional, Gromadziński, Leszek, additional, Grzelakowski, Paweł, additional, Kamiński, Leszek, additional, Kleinrok, Andrzej, additional, Kostkiewicz, Marcin, additional, Koziński, Marek, additional, Król, Paweł, additional, Kulawik, Tomasz, additional, Minczew, Gleb, additional, Mindykowski, Marcin, additional, Pawlak, Agnieszka, additional, Prokopczuk, Janusz, additional, Skonieczny, Grzegorz, additional, Sobkowicz, Bożena, additional, Sowiński, Sergiusz, additional, Stankala, Sebastian, additional, Szymański, Paweł, additional, Wester, Andrzej, additional, Wilczewski, Przemysław, additional, Bartuś, Stanisław, additional, Budaj, Andrzej, additional, Gąsior, Mariusz, additional, Gruchała, Marcin, additional, Drożdż, Jarosław, additional, Jaguszewski, Miłosz, additional, Jankowski, Piotr, additional, Legutko, Jacek, additional, Lesiak, Maciej, additional, Leszek, Przemysław, additional, Mitkowski, Przemysław, additional, Nessler, Jadwiga, additional, Tomaszuk‐Kazberuk, Anna, additional, Tycińska, Agnieszka, additional, Zdrojewski, Tomasz, additional, and Kaźmierczak, Jarosław, additional

Published
2021
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23. A new approach to ticagrelor-based de-escalation of antiplatelet therapy after acute coronary syndrome. A rationale for a randomized, double-blind, placebo-controlled, investigator-initiated, multicenter clinical study

Author

Kubica, Jacek, primary, Adamski, Piotr, additional, Niezgoda, Piotr, additional, Kubica, Aldona, additional, Podhajski, Przemysław, additional, Barańska, Malwina, additional, Umińska, Julia M., additional, Pietrzykowski, Łukasz, additional, Ostrowska, Małgorzata, additional, Siller-Matula, Jolanta M., additional, Badarienė, Jolita, additional, Bartuś, Stanisław, additional, Budaj, Andrzej, additional, Dobrzycki, Sławomir, additional, Fidor, Łukasz, additional, Gąsior, Mariusz, additional, Gessek, Jacek, additional, Gierlotka, Marek, additional, Gil, Robert, additional, Gorący, Jarosław, additional, Grzelakowski, Paweł, additional, Hajdukiewicz, Tomasz, additional, Jaguszewski, Miłosz, additional, Janion, Marianna, additional, Kasprzak, Jarosław, additional, Kern, Adam, additional, Klecha, Artur, additional, Kleinrok, Andrzej, additional, Kochman, Wacław, additional, Krakowiak, Bartosz, additional, Legutko, Jacek, additional, Lesiak, Maciej, additional, Nosal, Marcin, additional, Piotrowski, Grzegorz, additional, Przybylski, Andrzej, additional, Roleder, Tomasz, additional, Skonieczny, Grzegorz, additional, Sobieszek, Grzegorz, additional, Tycińska, Agnieszka, additional, Wojciechowski, Dariusz, additional, Wojakowski, Wojciech, additional, Wójcik, Jarosław, additional, Zielińska, Marzenna, additional, Żurakowski, Aleksander, additional, Specchia, Giuseppe, additional, Gorog, Diana A., additional, and Navarese, Eliano P., additional

Published
2021
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24. Transvenous Lead Extraction without Procedure-Related Deaths in 1000 Consecutive Patients: A Single-Center Experience

Author

Stefańczyk,Paweł, Nowosielecka,Dorota, Tułecki,Łukasz, Tomków,Konrad, Polewczyk,Anna, Jacheć,Wojciech, Kleinrok,Andrzej, Borzęcki,Wojciech, Kutarski,Andrzej, Stefańczyk,Paweł, Nowosielecka,Dorota, Tułecki,Łukasz, Tomków,Konrad, Polewczyk,Anna, Jacheć,Wojciech, Kleinrok,Andrzej, Borzęcki,Wojciech, and Kutarski,Andrzej

Abstract

Paweł Stefańczyk,1 Dorota Nowosielecka,1 Łukasz Tułecki,2 Konrad Tomków,2 Anna Polewczyk,3,4 Wojciech Jacheć,5 Andrzej Kleinrok,1,6 Wojciech Borzęcki,1 Andrzej Kutarski7 1Department of Cardiology, The Pope John Paul II Province Hospital of Zamość, Zamość, Poland; 2Department of Cardiac Surgery, The Pope John Paul II Province Hospital of Zamość, Zamość, Poland; 3Department of Physiology, Pathophysiology, and Clinical Immunology, Collegium Medicum of Jan Kochanowski University, Kielce, Poland; 4Department of Cardiac Surgery, Świętokrzyskie Cardiology Center, Kielce, Poland; 5Silesian Medical University, 2nd Department of Cardiology, Zabrze, Poland; 6Medical College, Department of Physiotherapy, University of Information Technology and Management, Rzeszów, Poland; 7Department of Cardiology, Medical University, Lublin, PolandCorrespondence: Anna PolewczykDepartment of Physiology, Pathophysiology, and Clinical Immunology, Collegium Medicum of Jan Kochanowski University, 19A, Aleja IX Wieków Kielc Str 25-317, Kielce, PolandTel +48600024074Email annapolewczyk@wp.plBackground: Transvenous lead extraction (TLE) is now a first-line technique for the treatment of complications related to cardiac implantable electronic devices. The aim of the study was to demonstrate that it is possible to safely perform difficult TLE procedures with a maximum reduction of peri-procedural major complications.Methods: A total of 1000 consecutive patients undergoing TLE in a single high-volume center from 2016 to 2019 were studied. All procedures were performed in a hybrid room or operating room by a specialized TLE team. TLE was performed under general anesthesia and monitored by transesophageal echocardiography, and the operating room was suitably equipped for immediate surgical intervention. The effectiveness and safety

Published
2021

26. ANalgesic Efficacy and safety of MOrphiNe versus methoxyflurane in patients with acute myocardial infarction: the rationale and design of the ANEMON-SIRIO 3 study: a multicentre, open-label, phase II, randomised clinical trial

Author

Kubica, Aldona, primary, Kosobucka, Agata, additional, Niezgoda, Piotr, additional, Adamski, Piotr, additional, Buszko, Katarzyna, additional, Lesiak, Maciej, additional, Wojakowski, Wojciech, additional, Gasior, Mariusz, additional, Gorący, Jarosław, additional, Kleinrok, Andrzej, additional, Nadolny, Klaudiusz, additional, Navarese, Eliano, additional, and Kubica, Jacek, additional

Published
2021
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27. Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial

Author

Maggioni, Aldo P., Greene, Stephen J., Fonarow, Gregg C., Böhm, Michael, Zannad, Faiez, Solomon, Scott D., Lewis, Eldrin F., Baschiera, Fabio, Hua, Tsushung A., Gimpelewicz, Claudio R., Lesogor, Anastasia, Gheorghiade, Mihai, Ramos, Silvina, Luna, Alejandra, Miriuka, Santiago, Diez, Mirta, Perna, Eduardo, Luquez, Hugo, Pinna, Jorge Garcia, Castagnino, Jorge, Alvarenga, Pablo, Ibañez, Julio, Blumberg, Eduardo Salmon, Dizeo, Claudio, Guerrero, Rodolfo Ahuad, Schygiel, Pablo, Milesi, Rodolfo, Sosa, Carlos, Hominal, Miguel, Marquez, Lilia Lobo, Poy, Carlos, Hasbani, Eduardo, Vico, Marisa, Fernandez, Alberto, Vita, Nestor, Vanhaecke, Johan, De Keulenaer, Gilles, Striekwold, Harry, Vervoort, Geert, Vrolix, Mathias, Henry, Philippe, Dendale, Paul, Smolders, Walter, Marechal, Patrick, Vandekerckhove, Hans, Oliveira, Mucio, Jr., Neuenschwande, Fernando, Reis, Gilmar, Saraiva, Jose, Bodanese, Luiz, Canesin, Manoel, Greco, Oswaldo, Bassan, Roberto, Marino, Roberto Luis, Giannetti, Nadia, Moe, Gordon, Sussex, Bruce, Sheppard, Richard, Huynh, Thao, Stewart, Robert, Haddad, Haissam, Echeverria, Luis, Quintero, Adalberto, Torres, Adriana, Jaramillo, Mónica, Lopez, Mónica, Mendoza, Fernan, Florez, Noel, Cotes, Carlos, Garcia, Magali, Belohlavek, Jan, Hradec, Jaromir, Peterka, Martin, Gregor, Pavel, Monhart, Zdenek, Jansky, Petr, Kettner, Jiri, Reichert, Petr, Spinar, Jindrich, Brabec, Tomas, Hutyra, Martin, Solar, Miroslav, Pietilä, Mikko, Nyman, Kai, Pajari, Risto, Cohen, Ariel, Galinier, Michel, Gosse, Philippe, Livarek, Bernard, Neuder, Yannick, Jourdain, Patrick, Picard, François, Isnard, Richard, Hoppe, Uta, Kaeaeb, Stefan, Rosocha, Stefan, Prondzinsky, Roland, Felix, Stephan, Duengen, Hans-Dirk, Figulla, Hans-Reiner, Fischer, Sven, Behrens, Steffen, Stawowy, Philipp, Kruells-Muench, Juergen, Knebel, Fabian, Nienaber, Christoph, Werner, Dierk, Aron, Wilma, Remppis, Bjoern, Hambrecht, Rainer, Kisters, Klaus, Werner, Nikos, Hoffmann, Stefan, Rossol, Siegbert, Geiss, Ernst, Graf, Kristof, Hamann, Frank, von Scheidt, Wolfgang, Schwinger, Robert, Tebbe, Ulrich, Costard-Jaeckle, Angelika, Lueders, Stephan, Heitzer, Thomas, Leutermann-Oei, Marie-Louise, Braun-Dullaeus, Ruediger, Roehnisch, Jens-Uwe, Muth, Gerhard, Goette, Andreas, Rotter, Achim, Ebelt, Henning, Olbrich, Hans-Georg, Mitrovic, Veselin, Hengstenberg, Christian, Schellong, Sebastian, Zamolyi, Karoly, Vertes, Andras, Matoltsy, Andras, Palinkas, Attila, Herczeg, Bela, Apro, Dezso, Lupkovics, Geza, Tomcsanyi, Janos, Toth, Kalman, Mathur, Atul, Banker, Darshan, Bharani, Anil, Arneja, Jaspal, Khan, Aziz, Gadkari, Milind, Hiremath, Jagdish, Patki, Nitin, Kumbla, Makund, Santosh, M.J., Ravikishore, A.G., Abhaichand, Rajpal, Maniyal, Vijayakukmar, Nanjappa, Manjunath, Reddy, P. Naveen, Chockalingam, Kulasekaran, Premchand, Rajendra, Mahajan, Vijay, Lewis, Basil, Wexler, Dov, Shochat, Michael, Keren, Andre, Omary, Muhamad, Katz, Amos, Marmor, Alon, Lembo, Giuseppe, Di Somma, Salvatore, Boccanelli, Alessandro, Barbiero, Mario, Pajes, Giuseppe, De Servi, Stefano, Greco, Dott Cosimo, De Santis, Fernando, Floresta, Agata, Visconti, Luigi Oltrona, Piovaccari, Giancarlo, Cavallini, Claudio, Di Biase, Matteo, Masini, Dott Franco, Vassanelli, Corrado, Viecca, Maurizio, Cangemi, Dott Francesco, Pirelli, Salvatore, Borghi, Claudio, Volpe, Massimo, Branzi, Angelo, Percoco, Dott Giovanni, Severi, Silvia, Santini, Alberto, De Lorenzi, Ettore, Metra, Marco, Zacà, Valerio, Mortara, Andrea, Tranquilino, Francisco P., Babilonia, Noe A., Ferrolino, Arthur M., Manlutac, Benjamin, Jr, Dluzniewski, Miroslaw, Dzielinska, Zofia, Nowalany-Kozie, Ewa, Mazurek, Walentyna, Wierzchowiecki, Jerzy, Wysokinski, Andrzej, Szachniewicz, Joanna, Romanowski, Witold, Krauze-Wielicka, Magdalena, Jankowski, Piotr, Berkowski, Piotr, Szelemej, Roman, Kleinrok, Andrzej, Kornacewicz-Jac, Zdzislawa, Vintila, Marius, Vladoianu, Mircea, Militaru, Constantin, Dan, Gheorghe, Dorobantu, Maria, Dragulescu, Stefan, Kostenko, Victor, Vishnevsky, Alexandr, Goloschekin, Boris, Tyrenko, Vadim, Gordienko, Alexander, Kislyak, Oxana, Martsevich, Sergey, Kuchmin, Alexey, Karpov, Yurii, Fomin, Igor, Shvarts, Yury, Orlikova, Olga, Ershova, Olga, Berkovich, Olga, Sitnikova, Maria, Pakhomova, Inna, Boldueva, Svetlana, Tyurina, Tatiana, Simanenkov, Vladimir, Boyarkin, Mikhail, Novikova, Nina, Tereschenko, Sergey, Zadionchenko, Vladimir, Shogenov, Zaur, Gordeev, Ivan, Moiseev, Valentin, Wong, Raymond, Ong, Hean Yee, Le Tan, Ju, Goncalvesova, Eva, Kovar, Frantisek, Skalina, Ivan, Kasperova, Viera, Hojerova, Silvia, Szentivanyi, Miroslav, Stancak, Branislav, Babcak, Marian, Kycina, Peter, Poliacik, Pavol, Toth, Peter, Sirotiakova, Jana, de Sa, Esteban Lopez, Bueno, Manuel Gomez, Selles, Manuel Martinez, Cabrera, Jose Angel, Freire, Ramon Bover, Gonzalez Juanatey, Jose Ramon, Comin, Josep, Soriano, FranciscoRidocci, Lopez, Alejandro, Vicho, Raul, Lama, Manuel Geraldia, Schaufelberger, Maria, Brunotte, Richard, Ullman, Bengt, Hagerman, Inger, Cizinsky, Stella, Cherng, Wen-Jin, Yu, Wen-Chung, Kuo, Chi-Tai, Chang, Kuan-Cheng, Lai, Wen-Ter, Kuo, Jen-Yuan, Ural, Dilek, Badak, Ozer, Akin, Mustafa, Yigit, Zerrin, Yokusoglu, Mehmet, Yilmaz, Mehmet, Abaci, Adnan, Ebinc, Haksun, Perlman, Richard, Parish, David, Bergin, James, Burnham, Kenneth, Brown, Christopher, Lundbye, Justin, Williams, Celeste, Eisen, Howard, Juneman, Elizabeth, Joseph, Susan, Peberdy, Mary Ann, Peura, Jennifer, Gupta, Vishal, Habet, Kalim, French, William, Mody, Freny, Graham, Susan, Hazelrigg, Monica, Chung, Eugene, Dunlap, Stephanie, Nikolaidis, Lazaros, Najjar, Samer, Katz, Richard, Murali, Srinivas, Izzo, Joseph L., Callister, Tracy, Phillips, Roland, Lippolis, Nicholas, Winterton, John, Meymandi, Sheba, Heilman, Karl, III, Oren, Ron, Zolty, Ronald, Brottman, Michael, Gunawardena, D.R., Adams, Kirkwood, Barnard, Denise, Klapholz, Marc, and Fulmer, James

Published
2013
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28. Characteristics of patients from the Polish Registry of Acute Coronary Syndromes during the COVID-19 pandemic: the first report

Author

Hawranek, Michał, primary, Grygier, Marek, additional, Bujak, Kamil, additional, Bartuś, Stanisław, additional, Gierlotka, Marek, additional, Wojakowski, Wojciech, additional, Legutko, Jacek, additional, Lesiak, Maciej, additional, Pączek, Piotr, additional, Kleinrok, Andrzej, additional, Milewski, Krzysztof, additional, Kubica, Jacek, additional, Tajstra, Mateusz, additional, Dudek, Dariusz, additional, Witkowski, Adam, additional, and Gąsior, Mariusz, additional

Published
2021
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32. The rationale for Multilevel Educational and Motivational Intervention in Patients after Myocardial Infarction (MEDMOTION) project is to support multicentre randomized clinical trial Evaluating Safety and Efficacy of Two Ticagrelor-based De-escalation Antiplatelet Strategies in Acute Coronary Syndrome (ELECTRA – SIRIO 2)

Author

Kubica, Aldona, primary, Adamski, Piotr, additional, Bączkowska, Anna, additional, Czarnecki, Damian, additional, Derewiecki, Tomasz, additional, Donderski, Rafał, additional, Grzechowiak, Elżbieta, additional, Jasiewicz, Małgorzata, additional, Kleinrok, Andrzej, additional, Kozera, Grzegorz, additional, Michalski, Piotr, additional, Sulikowska, Beata, additional, Szeremeta, Ewa, additional, Umińska, Julia, additional, Ulaszewska, Katarzyna, additional, Ziółkowski, Marcin, additional, and Kubica, Jacek, additional

Published
2020
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33. Prolonged antithrombotic therapy in patients after acute coronary syndrome: A critical appraisal of current European Society of Cardiology guidelines

Author

Kubica, Jacek, primary, Adamski, Piotr, additional, Niezgoda, Piotr, additional, Alexopoulos, Dimitrios, additional, Badarienė, Jolita, additional, Budaj, Andrzej, additional, Buszko, Katarzyna, additional, Dudek, Dariusz, additional, Fabiszak, Tomasz, additional, Gąsior, Mariusz, additional, Gil, Robert, additional, Gorog, Diana A., additional, Grajek, Stefan, additional, Gurbel, Paul A., additional, Gruchała, Marcin, additional, Jaguszewski, Miłosz J., additional, James, Stefan, additional, Jeong, Young-Hoon, additional, Jilma, Bernd, additional, Kasprzak, Jarosław D., additional, Kleinrok, Andrzej, additional, Kubica, Aldona, additional, Kuliczkowski, Wiktor, additional, Legutko, Jacek, additional, Lesiak, Maciej, additional, Siller-Matula, Jolanta M., additional, Nadolny, Klaudiusz, additional, Pstrągowski, Krzysztof, additional, Di Somma, Salvatore, additional, Specchia, Giuseppe, additional, Stępińska, Janina, additional, Tantry, Udaya S., additional, Tycińska, Agnieszka, additional, Verdoia, Monica, additional, Wojakowski, Wojciech, additional, and Navarese, Eliano P., additional

Published
2020
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36. Clinical characteristics and treatment profiles of patients after acute myocardial infarction with left ventricular ejection fraction below 40%: a short 2018–2019 report on the PL‑ACS registry

Author

Kozłowska, Bogna, primary, Leszek, Przemysław, additional, Niedziela, Jacek, additional, Parma, Zofia, additional, Nessler, Jadwiga, additional, Lelonek, Małgorzata, additional, Hiczkiewicz, Jarosław, additional, Kleinrok, Andrzej, additional, Górny, Zygmunt, additional, Pączek, Piotr, additional, Reszka, Zygfryd, additional, Janion, Marianna, additional, Witkowski, Adam, additional, Dudek, Dariusz, additional, Gąsior, Mariusz, additional, and Rozentryt, Piotr, additional

Published
2020
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37. Transesophageal Echocardiography as a Monitoring Tool during Transvenous Lead Extraction—Does It Improve Procedure Effectiveness?

Author

Nowosielecka, Dorota, primary, Jacheć, Wojciech, additional, Polewczyk, Anna, additional, Tułecki, Łukasz, additional, Tomków, Konrad, additional, Stefańczyk, Paweł, additional, Tomaszewski, Andrzej, additional, Brzozowski, Wojciech, additional, Szcześniak-Stańczyk, Dorota, additional, Kleinrok, Andrzej, additional, and Kutarski, Andrzej, additional

Published
2020
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38. Prevalence, characteristics, and prognostic implications of type 2 diabetes in patients with myocardial infarction: the Polish Registry of Acute Coronary Syndromes (PL‑ACS) annual 2018 report

Author

Niedziela, Jacek T., primary, Hiczkiewicz, Jarosław, additional, Kleinrok, Andrzej, additional, Pączek, Piotr, additional, Leszek, Przemysław, additional, Lelonek, Małgorzata, additional, Rozentryt, Piotr, additional, Parma, Zofia, additional, Witkowski, Adam, additional, Bartuś, Stanisław, additional, Zdrojewski, Tomasz, additional, Buszman, Paweł, additional, Kaźmierczak, Jarosław, additional, Strojek, Krzysztof, additional, and Gąsior, Mariusz, additional

Published
2020
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42. Prolonged antithrombotic therapy in patients after acute coronary syndrome : A critical appraisal of current European Society of Cardiology guidelines

Author

Kubica, Jacek, Adamski, Piotr, Niezgoda, Piotr, Alexopoulos, Dimitrios, Badariene, Jolita, Budaj, Andrzej, Buszko, Katarzyna, Dudek, Dariusz, Fabiszak, Tomasz, Gasior, Mariusz, Gil, Robert, Gorog, Diana A., Grajek, Stefan, Gurbel, Paul A., Gruchala, Marcin, Jaguszewski, Milosz J., James, Stefan, Jeong, Young-Hoon, Jilma, Bernd, Kasprzak, Jaroslaw D., Kleinrok, Andrzej, Kubica, Aldona, Kuliczkowski, Wiktor, Legutko, Jacek, Lesiak, Maciej, Siller-Matula, Jolanta M., Nadolny, Klaudiusz, Pstragowski, Krzysztof, Di Somma, Salvatore, Specchia, Giuseppe, Stepinska, Janina, Tantry, Udaya S., Tycinska, Agnieszka, Verdoia, Monica, Wojakowski, Wojciech, Navarese, Eliano P., Kubica, Jacek, Adamski, Piotr, Niezgoda, Piotr, Alexopoulos, Dimitrios, Badariene, Jolita, Budaj, Andrzej, Buszko, Katarzyna, Dudek, Dariusz, Fabiszak, Tomasz, Gasior, Mariusz, Gil, Robert, Gorog, Diana A., Grajek, Stefan, Gurbel, Paul A., Gruchala, Marcin, Jaguszewski, Milosz J., James, Stefan, Jeong, Young-Hoon, Jilma, Bernd, Kasprzak, Jaroslaw D., Kleinrok, Andrzej, Kubica, Aldona, Kuliczkowski, Wiktor, Legutko, Jacek, Lesiak, Maciej, Siller-Matula, Jolanta M., Nadolny, Klaudiusz, Pstragowski, Krzysztof, Di Somma, Salvatore, Specchia, Giuseppe, Stepinska, Janina, Tantry, Udaya S., Tycinska, Agnieszka, Verdoia, Monica, Wojakowski, Wojciech, and Navarese, Eliano P.

Abstract

The increased risk of non-cardiovascular death in patients receiving clopidogrel or prasugrel in comparison with the placebo group in the Dual Antiplatelet Therapy (DAPT) trial in contrast to the decreased risk of cardiovascular death and all-cause death seen in patients treated with low-dose ticagrelor in the EU label population of the PEGASUS-TIMI 54 trial, resulted in inclusion in the 2020 ESC NSTE-ACS guidelines the recommendation for use of clopidogrel or prasugrel only if the patient is not eligible for treatment with ticagrelor. The prevalence of the primary outcome composed of cardiovascular death, stroke, or myocardial infarction was lower in the low-dose rivaroxaban and acetylsalicylic acid (ASA) group than in the ASA-alone group in the COMPASS trial. Moreover, all-cause mortality and cardiovascular mortality rates were lower in the rivaroxaban-plus-ASA group. Comparison of the PEGASUS-TIMI 54 and COMPASS trial patient characteristics clearly shows that each of these treatment strategies should be addressed at different groups of patients. A greater benefit in post-acute coronary syndrome (ACS) patients with a high risk of ischemic events and without high bleeding risk may be expected with ASA and ticagrelor 60 mg b.i.d. when the therapy is continued without interruption or with short interruption only after ACS. On the other hand, ASA and rivaroxaban 2.5 mg b.i.d. seems to be a better option when indications for dual antithrombotic therapy (DATT) appear after a longer time from ACS (more than 2 years) and/or from cessation of DAPT (more than 1 year) and in patients with multiple vascular bed atherosclerosis. Thus, both options of DATTs complement each other rather than compete, as can be presumed from the recommendations. However, a direct comparison between these strategies should be tested in future clinical trials.

Published
2020
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43. Impact of COVID‐19 pandemic on acute heart failure admissions and mortality: a multicentre study (COV‐HF‐SIRIO 6 study).

Author

Kubica, Jacek, Ostrowska, Małgorzata, Stolarek, Wioleta, Kasprzak, Michał, Grzelakowska, Klaudyna, Kryś, Jacek, Kubica, Aldona, Adamski, Piotr, Podhajski, Przemysław, Navarese, Eliano Pio, Anielska‐Michalak, Edyta, Brycht, Oliwia, Curzytek, Andrzej, Dudek, Aneta, Gromadziński, Leszek, Grzelakowski, Paweł, Kamiński, Leszek, Kleinrok, Andrzej, Kostkiewicz, Marcin, and Koziński, Marek

Subjects
COVID-19 pandemic, HEART failure, HOSPITAL mortality
Abstract

Aims: The coronavirus disease‐2019 (COVID‐19) pandemic has changed the landscape of medical care delivery worldwide. We aimed to assess the influence of COVID‐19 pandemic on hospital admissions and in‐hospital mortality rate in patients with acute heart failure (AHF) in a retrospective, multicentre study. Methods and results: From 1 January 2019 to 31 December 2020, a total of 101 433 patients were hospitalized in 24 Cardiology Departments in Poland. The number of patients admitted due to AHF decreased by 23.4% from 9853 in 2019 to 7546 in 2020 (P < 0.001). We noted a significant reduction of self‐referrals in the times of COVID‐19 pandemic accounting 27.8% (P < 0.001), with increased number of AHF patients brought by an ambulance by 15.9% (P < 0.001). The length of hospital stay was overall similar (7.7 ± 2.8 vs. 8.2 ± 3.7 days; P = not significant). The in‐hospital all‐cause mortality in AHF patients was 444 (5.2%) in 2019 vs. 406 (6.5%) in 2020 (P < 0.001). A total number of AHF patients with concomitant COVID‐19 was 239 (3.2% of AHF patients hospitalized in 2020). The rate of in‐hospital deaths in AHF patients with COVID‐19 was extremely high accounting 31.4%, reaching up to 44.1% in the peak of the pandemic in November 2020. Conclusions: Our study indicates that the COVID‐19 pandemic led to (i) reduced hospital admissions for AHF; (ii) decreased number of self‐referred AHF patients and increased number of AHF patients brought by an ambulance; and (iii) increased in‐hospital mortality for AHF with very high mortality rate for concomitant AHF and COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2022
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44. To replace or to abandon and implant a new lead? Conservative approach creates new challenges (and risks) for the patients in future. Should we still wait for class 1 indications ? Case report and discussion of the problem.

Author

Stefańczyk, Paweł, primary, Borzęcki, Wojciech, additional, Tułecki, Łukasz, additional, Tomków, Konrad, additional, Nowosielecka, Dorota, additional, Kleinrok, Andrzej, additional, and Kutarski, Andrzej, additional

Published
2019
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47. Echocardiographic findings in patients with cardiac implantable electronic devices—analysis of factors predisposing to lead‐associated changes.

Author

Nowosielecka, Dorota, Polewczyk, Anna, Jacheć, Wojciech, Tułecki, Łukasz, Kleinrok, Andrzej, and Kutarski, Andrzej

Subjects
ARTIFICIAL implants, ELECTRONIC equipment, FACTOR analysis, TRANSESOPHAGEAL echocardiography, CARDIAC patients
Abstract

Background: The constant interaction between intracardiac leads and the heart and veins results in excessive accumulation of fibrous connective tissue around the leads. The extent of this pathological phenomenon, which is visible on transesophageal echocardiography (TEE), and predisposing factors are not well defined. Methods: We examined 936 transesophageal echocardiograms prior to transvenous lead extraction (TLE) performed at a high‐volume centre between 2015 and 2019. Results: The most important echocardiographic findings were fibrous binding sites between leads and cardiovascular structures, lead‐to‐lead adhesions, excessive lead loops, lead‐dependent tricuspid dysfunction (LDTD), asymptomatic masses on endocardial leads (AMEL) and vegetations. Fibrotic reaction within the walls of the heart and veins correlated with the presence of lead loops (OR = 1.771; p <.01) and lead dwell time (OR = 1.111; p <.001). Women were more likely to have excessive lead loops (OR = 1.639; p <.01), and the occurrence of loops increase with the number of implanted leads (OR = 2.557; p <.001). Heart failure (OR = 4.016; p <.001), lead looping (OR = 2.603; p <.01) and longer cumulative lead dwell time (OR = 1.017; p <.05) increased the likelihood of LDTD. A variety of AMEL were identified in this study, most commonly in patients with older leads (OR = 1.043; p <.001). Conclusions: Lead dwell time is the main factor predisposing to the occurrence of most lead‐associated phenomena visualized by TEE in patients with cardiac implantable electronic devices (CIED). Excessive looping of the lead is an important cause of fibrous binding sites and LDTD. AMEL are frequently detected in CIED patients, and their various forms concurrent with vegetations could represent an evolutionary stage of lead‐associated masses. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Treatment of patients with acute coronary syndrome: Recommendations for medical emergency teams: Focus on antiplatelet therapies. Updated experts’ standpoint

Author

Kubica, Jacek, primary, Adamski, Piotr, additional, Paciorek, Przemysław, additional, Ładny, Jerzy R., additional, Kalarus, Zbigniew, additional, Banasiak, Waldemar, additional, Kochman, Wacław, additional, Gorący, Jarosław, additional, Wożakowska-Kapłon, Beata, additional, Navarese, Eliano Pio, additional, Kleinrok, Andrzej, additional, Gil, Robert, additional, Lesiak, Maciej, additional, Drożdż, Jarosław, additional, Kubica, Aldona, additional, Filipiak, Krzysztof J., additional, Kaźmierczak, Jarosław, additional, Goch, Aleksander, additional, Grajek, Stefan, additional, Basiński, Andrzej, additional, Szarpak, Łukasz, additional, Grześk, Grzegorz, additional, Hoffman, Piotr, additional, Wojakowski, Wojciech, additional, Gąsior, Zbigniew, additional, Dobrzycki, Sławomir, additional, Siller-Matula, Jolanta M., additional, Witkowski, Adam, additional, Kuliczkowski, Wiktor, additional, Gruchała, Marcin, additional, Timler, Dariusz, additional, Opolski, Grzegorz, additional, Dudek, Dariusz, additional, Legutko, Jacek, additional, Zielińska, Marzenna, additional, and Wójcik, Jarosław, additional

Published
2018
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