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1. Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial

Author

Morin, Frederic, Rahman, Proton, Ariel, Federico, Berman, Alberto, Carrio, Judith, Lucero, Eleonora, Cocco, Jose Maldonado, Hidalgo, Rodolfo Pardo, Velasco, Jorge, Viola, Diego O., Grisar, Johannes, Resch, Heinrich, Scheinecker, Clemens, Melazzi, Ana Claudia, Roimicher, Luis, Scotton, Antonio Scafuto, Rodriguez, Aaron Alejandro Barrera, Molina, Francisco Fidencio Cons, Barragan, Sergio Duran, Skinner, Cassandra M., Tena, Cesar Francisco Pacheco, Remus, Cesar Ricardo Ramos, Rodriguez, Juan Cruz Rizo, Hong, Seung-Jae, Kang, Seong Wook, Lee, Chang Keun, Lee, Eun Bong, Lee, Sang Heon, Park, Min-Chan, Lee, Sang-Hoon, Dokoupilova, Eva, Dvorak, Zdenek, Malcova, Martina, Pvelka, Karel, Eklund, Kari K., Jarvinen, Pentti, Karjalainen, Anna, Paimela, Leena, Taniguchi, Yoshinori, Tsuda, Tokutaro, Tada, Kurisu, Dobashi, Hiroaki, Inui, Kentaro, Ueki, Yukitaka, Matsumoto, Yoshifuji, Hatta, Kazuhiro, Atsumi, Tatsuya, Goto, Hitoshi, Honjo, Shigeru, Matsui, Kiyoshi, Takakubo, Yuya, Neeck, Gunther, Wagner, Sylke, Braun, Jürgen, Blicharshi, Tomasz, Dudek, Anna, Hrycai, Pawel, Plebanski, Rafal, Drabiszcak-Piatkowska, Janina, Brzezicki, Jan, Krogulec, Marek, Opris-Belinski, Daniela, Ramazan, Ana Maria, Tronaru, Luminita, van de Sande, Marleen G., Matsievskaya, Galina, Schmidt, Evgeniya, Stanislav, Marina, Yakushin, Sergey, Ershova, Olga, Rebroy, Andrey, Churchill, Melvin A., Flint, Kathleen P., Greenwald, Maria, Howell, Mary P., Kaine, Jeffrey L., Kivitz, Alan, Klein, Steven J., Mueller, Eric C., Peters, Eric A., Querubin, Roel, Sayers, Michael E., Scoville, Craig D., Shanahan, Joseph C., Roseff, Richard, Hull, John E., Mallepalli, Jyothi R., Sebai, Mohamed B., Kimmel, Steven C., Goddard, David H., Mease, Philip J., Harris, Mark D., Mabaquiao, Arthur R., Diegel, Roger J., Thai, Christine, Rivera, Tania L., Perez-De Jesus, Amarilis, Soto-Raices, Oscar, Toro-Torres, Ramon, Pantojas, Carlos, Deodhar, Atul, van der Heijde, Désirée, Gensler, Lianne S, Kim, Tae-Hwan, Maksymowych, Walter P, Østergaard, Mikkel, Poddubnyy, Denis, Marzo-Ortega, Helena, Bessette, Louis, Tomita, Tetsuya, Leung, Ann, Hojnik, Maja, Gallo, Gaia, Li, Xiaoqi, Adams, David, Carlier, Hilde, and Sieper, Joachim

Published
2020
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2. Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trial

Author

Ahmed, Khalid, Alper, Jeffrey, Barkham, Nichol, Bennett, Ralph E., García, Francisco Javier Blanco, Alonso, Ricardo Blanco, Blumstein, Howard B., Brooks, Michael S., Burmester, Gerd-Rüdiger, Cagnoli, Patricia, Caldron, Paul H., Cantagrel, Alain, Chen, Der-Yuan, Churchill, Melvin A., Jr, Codding, Christine E., Combe, Benard, Deane, Peter M.G., Del Giudice, Jose, Deodhar, Atul A., Dhar, Rajat K., Dokoupilova, Eva, Egan, Rita M., Everding, Andrea, Galíndez, Eva, Genovese, Mark, Goddard, David H., Gottlieb, Alice, Goupille, Philippe, Griffin, Robert M., Gupta, Ramesh C., Hall, Stephen, Hatti, Kalpita, Howell, Mary P., Huang, Yu-Huei, Jajoo, Ramina, Janssen, Namieta M., Kiltz, Uta, Kivitz, Alan J., Klein, Steven J., Korkosz, Mariusz P., Kotha, Roshan, Kremer, Joel M., Lue, Cummins, de la Fuente, José Luis Marenco, Marzo-Ortega, Helena, Masmitja, Jordi Gratacós, Mease, Philip J., Meroni, Pier Luigi, Mueller, Eric C., Nandagudi, Anupama C., Nash, Peter, Fernández-Nebro, Antonio, Neuwelt, Clark M., Orbai, Ana Maria, Oza, Meera R., Parks, Deborah L., Pattanaik, Debendra, Rell-Bakalarska, Maria E., Rosmarin, David, Roussou, Euthalia, Rychlewska-Hanczewksa, Anna I., Sikes, David H., Stack, Michael T., Sunkureddi, Prashanth, Tahir, Hasan, Thaçi, Diamant, Tsai, Tsen-Fang, Turkiewicz, Anthony M., Unger, Leonore, Cabello, Raúl Veiga, Wagner, Ulf, Wei, Cheng-Chung, Wells, Alvin F., Youssef, Peter, Zielinska, Agnieszka, Kirkham, Bruce, Okada, Masato, Rahman, Proton, Burmester, Gerd-Ruediger, Adams, David H, Kerr, Lisa, Lee, Chin, and Shuler, Catherine L

Published
2017
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3. Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial

Author

Deodhar, Atul, primary, van der Heijde, Désirée, additional, Gensler, Lianne S, additional, Kim, Tae-Hwan, additional, Maksymowych, Walter P, additional, Østergaard, Mikkel, additional, Poddubnyy, Denis, additional, Marzo-Ortega, Helena, additional, Bessette, Louis, additional, Tomita, Tetsuya, additional, Leung, Ann, additional, Hojnik, Maja, additional, Gallo, Gaia, additional, Li, Xiaoqi, additional, Adams, David, additional, Carlier, Hilde, additional, Sieper, Joachim, additional, Morin, Frederic, additional, Rahman, Proton, additional, Ariel, Federico, additional, Berman, Alberto, additional, Carrio, Judith, additional, Lucero, Eleonora, additional, Cocco, Jose Maldonado, additional, Hidalgo, Rodolfo Pardo, additional, Velasco, Jorge, additional, Viola, Diego O., additional, Grisar, Johannes, additional, Resch, Heinrich, additional, Scheinecker, Clemens, additional, Melazzi, Ana Claudia, additional, Roimicher, Luis, additional, Scotton, Antonio Scafuto, additional, Rodriguez, Aaron Alejandro Barrera, additional, Molina, Francisco Fidencio Cons, additional, Barragan, Sergio Duran, additional, Skinner, Cassandra M., additional, Tena, Cesar Francisco Pacheco, additional, Remus, Cesar Ricardo Ramos, additional, Rodriguez, Juan Cruz Rizo, additional, Hong, Seung-Jae, additional, Kang, Seong Wook, additional, Lee, Chang Keun, additional, Lee, Eun Bong, additional, Lee, Sang Heon, additional, Park, Min-Chan, additional, Lee, Sang-Hoon, additional, Dokoupilova, Eva, additional, Dvorak, Zdenek, additional, Malcova, Martina, additional, Pvelka, Karel, additional, Eklund, Kari K., additional, Jarvinen, Pentti, additional, Karjalainen, Anna, additional, Paimela, Leena, additional, Taniguchi, Yoshinori, additional, Tsuda, Tokutaro, additional, Tada, Kurisu, additional, Dobashi, Hiroaki, additional, Inui, Kentaro, additional, Ueki, Yukitaka, additional, Matsumoto, Yoshifuji, additional, Hatta, Kazuhiro, additional, Atsumi, Tatsuya, additional, Goto, Hitoshi, additional, Honjo, Shigeru, additional, Matsui, Kiyoshi, additional, Takakubo, Yuya, additional, Neeck, Gunther, additional, Wagner, Sylke, additional, Braun, Jürgen, additional, Blicharshi, Tomasz, additional, Dudek, Anna, additional, Hrycai, Pawel, additional, Plebanski, Rafal, additional, Drabiszcak-Piatkowska, Janina, additional, Brzezicki, Jan, additional, Krogulec, Marek, additional, Opris-Belinski, Daniela, additional, Ramazan, Ana Maria, additional, Tronaru, Luminita, additional, van de Sande, Marleen G., additional, Matsievskaya, Galina, additional, Schmidt, Evgeniya, additional, Stanislav, Marina, additional, Yakushin, Sergey, additional, Ershova, Olga, additional, Rebroy, Andrey, additional, Churchill, Melvin A., additional, Flint, Kathleen P., additional, Greenwald, Maria, additional, Howell, Mary P., additional, Kaine, Jeffrey L., additional, Kivitz, Alan, additional, Klein, Steven J., additional, Mueller, Eric C., additional, Peters, Eric A., additional, Querubin, Roel, additional, Sayers, Michael E., additional, Scoville, Craig D., additional, Shanahan, Joseph C., additional, Roseff, Richard, additional, Hull, John E., additional, Mallepalli, Jyothi R., additional, Sebai, Mohamed B., additional, Kimmel, Steven C., additional, Goddard, David H., additional, Mease, Philip J., additional, Harris, Mark D., additional, Mabaquiao, Arthur R., additional, Diegel, Roger J., additional, Thai, Christine, additional, Rivera, Tania L., additional, Perez-De Jesus, Amarilis, additional, Soto-Raices, Oscar, additional, Toro-Torres, Ramon, additional, and Pantojas, Carlos, additional

Published
2020
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4. Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trial

Author

Nash, Peter, primary, Kirkham, Bruce, additional, Okada, Masato, additional, Rahman, Proton, additional, Combe, Benard, additional, Burmester, Gerd-Ruediger, additional, Adams, David H, additional, Kerr, Lisa, additional, Lee, Chin, additional, Shuler, Catherine L, additional, Genovese, Mark, additional, Ahmed, Khalid, additional, Alper, Jeffrey, additional, Barkham, Nichol, additional, Bennett, Ralph E., additional, García, Francisco Javier Blanco, additional, Alonso, Ricardo Blanco, additional, Blumstein, Howard B., additional, Brooks, Michael S., additional, Burmester, Gerd-Rüdiger, additional, Cagnoli, Patricia, additional, Caldron, Paul H., additional, Cantagrel, Alain, additional, Chen, Der-Yuan, additional, Churchill, Melvin A., additional, Codding, Christine E., additional, Deane, Peter M.G., additional, Del Giudice, Jose, additional, Deodhar, Atul A., additional, Dhar, Rajat K., additional, Dokoupilova, Eva, additional, Egan, Rita M., additional, Everding, Andrea, additional, Galíndez, Eva, additional, Goddard, David H., additional, Gottlieb, Alice, additional, Goupille, Philippe, additional, Griffin, Robert M., additional, Gupta, Ramesh C., additional, Hall, Stephen, additional, Hatti, Kalpita, additional, Howell, Mary P., additional, Huang, Yu-Huei, additional, Jajoo, Ramina, additional, Janssen, Namieta M., additional, Kiltz, Uta, additional, Kivitz, Alan J., additional, Klein, Steven J., additional, Korkosz, Mariusz P., additional, Kotha, Roshan, additional, Kremer, Joel M., additional, Lue, Cummins, additional, de la Fuente, José Luis Marenco, additional, Marzo-Ortega, Helena, additional, Masmitja, Jordi Gratacós, additional, Mease, Philip J., additional, Meroni, Pier Luigi, additional, Mueller, Eric C., additional, Nandagudi, Anupama C., additional, Nash, Peter, additional, Fernández-Nebro, Antonio, additional, Neuwelt, Clark M., additional, Orbai, Ana Maria, additional, Oza, Meera R., additional, Parks, Deborah L., additional, Pattanaik, Debendra, additional, Rell-Bakalarska, Maria E., additional, Rosmarin, David, additional, Roussou, Euthalia, additional, Rychlewska-Hanczewksa, Anna I., additional, Sikes, David H., additional, Stack, Michael T., additional, Sunkureddi, Prashanth, additional, Tahir, Hasan, additional, Thaçi, Diamant, additional, Tsai, Tsen-Fang, additional, Turkiewicz, Anthony M., additional, Unger, Leonore, additional, Cabello, Raúl Veiga, additional, Wagner, Ulf, additional, Wei, Cheng-Chung, additional, Wells, Alvin F., additional, Youssef, Peter, additional, and Zielinska, Agnieszka, additional

Published
2017
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5. Association of Anti–3‐Hydroxy‐3‐Methylglutaryl‐Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients

Author

Kishi, Takayuki, Rider, Lisa G., Pak, Katherine, Barillas‐Arias, Lilliana, Henrickson, Michael, McCarthy, Paul L., Shaham, Bracha, Weiss, Pamela F., Horkayne‐Szakaly, Iren, Targoff, Ira N., Miller, Frederick W., Mammen, Andrew L., Abramson, Leslie S., Albert, Daniel A., Baer, Alan N., Balboni, Imelda M., Ballinger, Susan, Becker, Mara, Bingham, C. April, Bohnsack, John F., Botstein, Gary R., Carrasco, Ruy, Cartwright, Victoria W., Chao, Chun Peng T., Cron, Randy Q., Curiel, Rodolfo, DeGuzman, Marietta M., De la Pena, Wendy, Eberhard, B. Anne, Edelheit, Barbara S., Ellsworth, Janet, Finkel, Terri H., Fuhlbrigge, Robert C., Gabriel, Christos A., Gedalia, Abraham, Gewanter, Harry L., Goldmuntz, Ellen A., Goldsmith, Donald P., Gottlieb, Beth S., Graham, Brent, Griffin, Thomas A., Haftel, Hilary M., Hannan, William, Hennon, Teresa, Hoeltzel, Mark F., Hollister, J. Roger, Hopp, Russell J., Imundo, Lisa F., Jansen, Anna, Jarvis, James, Jerath, Rita S., Johnson, Courtney R., Jones, Olcay Y., Jung, Lawrence K., Kamdar, Ankur, Katona, Ildy M., Kim, Hanna, Kim, Susan, Kingsbury, Daniel J., Klein, Steven J., Lang, Bianca A., Levine, Johanan, Lindsley, Carol B., Mamyrova, Gulnara, Mitchell, Ray, Morishima, Chihiro, Moser, David W., Murphy, Frederick T., Myers, Linda K., Nanda, Kabita, Nativ, Simona, Oral, Elif A., Ostrov, Barbara E., Pappu, Ramesh, Parker, Christopher T., Passo, Murray H., Perez, Maria D., Person, Donald A., Punaro, Marilyn G., Rabinovich, C. Egla, Rennebohm, Robert M., Rivas‐Chacon, Rafael F., Ronis, Tova, Rosenkranz, Margalit, Schiffenbauer, Adam, Sheets, Robert M., Sherry, David D., Sills, Edward M., Sinal, Sara H., Stoll, Matthew, Sule, Sangeeta D., Sundel, Robert P., Vehe, Richard K., Vogelgesang, Scott A., Wargula, Jennifer C., Yung, Christine M., and Zemel, Lawrence S.

Abstract

Autoantibodies recognizing 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) are associated with statin exposure, the HLA allele DRB1*11:01, and necrotizing muscle biopsies in adult myositis patients. The aim of this study was to characterize the features of juvenile anti‐HMGCR‐positive myositis patients. The sera of 440 juvenile myositis patients were screened for anti‐HMGCR autoantibodies. Demographic and clinical features, responses to therapy, and HLA alleles were assessed. The features of anti‐HMGCR‐positive patients were compared to those of previously described adult patients with this autoantibody and to children with other myositis‐specific autoantibodies (MSAs). Five of 440 patients (1.1%) were anti‐HMGCR‐positive; none had taken statin medications. Three patients had rashes characteristic of juvenile dermatomyositis and 2 patients had immune‐mediated necrotizing myopathies. The median highest creatine kinase (CK) level of anti‐HMGCR‐positive subjects was 17,000 IU/liter. All patients had severe proximal muscle weakness, distal weakness, muscle atrophy, joint contractures, and arthralgias, which were all more prevalent in HMGCR‐positive subjects compared to MSA‐negative patients or those with other MSAs. Anti‐HMGCR‐positive patients had only partial responses to multiple immunosuppressive medications, and their disease often took a chronic course. The DRB1*07:01 allele was present in all 5 patients, compared to 26.25% of healthy controls (corrected P= 0.01); none of the 5 juvenile patients had DRB1*11:01. Compared to children with other MSAs, muscle disease appears to be more severe in those with anti‐HMGCR autoantibodies. Like adults, children with anti‐HMGCR autoantibodies have severe weakness and high CK levels. In contrast to adults, in anti‐HMGCR‐positive children, there is a strong association with HLA–DRB1*07:01.

Published
2017
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