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2. Haptoglobin therapy has differential effects depending on severity of canine septic shock and cell‐free hemoglobin level

Author

Remy, Kenneth E, Cortés‐Puch, Irene, Sun, Junfeng, Feng, Jing, Lertora, Juan J, Risoleo, Thomas, Katz, Julia, Basu, Swati, Liu, Xiaohua, Perlegas, Andreas, Kim‐Shapiro, Daniel B, Klein, Harvey G, Natanson, Charles, and Solomon, Steven B

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Sepsis, Hematology, Infectious Diseases, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Inflammatory and immune system, Infection, Animals, Disease Models, Animal, Dogs, Erythrocyte Transfusion, Haptoglobins, Hemoglobins, Pneumonia, Staphylococcal, Shock, Septic, Cardiorespiratory Medicine and Haematology, Immunology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundDuring sepsis, higher plasma cell-free hemoglobin (CFH) levels portend worse outcomes. In sepsis models, plasma proteins that bind CFH improve survival. In our canine antibiotic-treated Staphylococcus aureus pneumonia model, with and without red blood cell (RBC) exchange transfusion, commercial human haptoglobin (Hp) concentrates bound and compartmentalized CFH intravascularly, increased CFH clearance, and lowered iron levels, improving shock, lung injury, and survival. We now investigate in our model how very high CFH levels and treatment time affect Hp's beneficial effects.Materials and methodsTwo separate canine pneumonia sepsis Hp studies were undertaken: one with exchange transfusion of RBCs after prolonged storage to raise CFH to very high levels and another with rapidly lethal sepsis alone to shorten time to treat. All animals received continuous standard intensive care unit supportive care for 96 hours.ResultsOlder RBCs markedly elevated plasma CFH levels and, when combined with Hp therapy, created supraphysiologic CFH-Hp complexes that did not increase CFH or iron clearance or improve lung injury and survival. In a rapidly lethal bacterial challenge model without RBC transfusion, Hp binding did not increase clearance of complexes or iron or show benefits seen previously in the less lethal model.DiscussionHigh-level CFH-Hp complexes may impair clearance mechanisms and eliminate Hp's beneficial effect during sepsis. Rapidly lethal sepsis narrows the therapeutic window for CFH and iron clearance, also decreasing Hp's beneficial effects. In designing clinical trials, dosing and kinetics may be critical factors if Hp infusion is used to treat sepsis.

Published
2019

5. Immunohaematological complications in patients with sickle cell disease after haemopoietic progenitor cell transplantation: a prospective, single-centre, observational study

Author

Allen, Elizabeth S, Srivastava, Kshitij, Hsieh, Matthew M, Fitzhugh, Courtney D, Klein, Harvey G, Tisdale, John F, and Flegel, Willy A

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Immunology, Stem Cell Research, Organ Transplantation, Clinical Research, Regenerative Medicine, Sickle Cell Disease, Rare Diseases, Hematology, Transplantation, Blood, Adult, Anemia, Sickle Cell, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Male, Prospective Studies, Transplantation Conditioning, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular medicine and haematology
Abstract

BackgroundHaemopoietic progenitor cell (HPC) transplantation can cure sickle cell disease. Non-myeloablative conditioning typically results in donor-derived erythrocytes and stable mixed chimerism of recipient-derived and donor-derived leucocytes. Exposure to donor antigens from the HPC graft and new red cell antibodies induced by transfusion can lead to immunohaematological complications. We assessed the incidence of such complications among HPC transplant recipients with sickle cell disease.MethodsThe study population was all patients with sickle cell disease enrolled before March 31, 2015, in the three clinical trials of non-myeloablative HPC transplantation at the National Institutes of Health. We assessed formation of new red cell antibodies after transplantation and red cell incompatibility between donors and recipients.Findings61 patients were enrolled, 42 were HLA matched and 19 were haploidentical. Nine (15%) had immunohaematological complications. Before HPC transplantation, three patients had antibodies incompatible with their donors. After HPC transplantation, new red cell antibodies were seen in six patients (11 alloantibodies and two autoantibodies), among whom three developed antibodies incompatible with donor or recipient red cells and three developed compatible antibodies. The clinical course of complications was highly variable, from no severe effects attributable to antibodies, to sustained reticulocytopenia, to near-fatal haemolysis. We found no significant correlation between immunohaematological complications and graft failure, graft rejection, or death.InterpretationClinical effects ranged from seemingly not clinically important to potentially fatal. In patients with sickle cell disease, donor and recipient red cell phenotypes should be carefully assessed before transplantation to minimise and manage the risk of immunohaematological complications.FundingIntramural Research Program and National Institutes of Health.

Published
2017

8. Hemoglobin-based transfusion strategies for cardiovascular and other diseases: restrictive, liberal, or neither?

Author

Natanson, Charles, Applefeld, Willard N., and Klein, Harvey G.

Abstract

A “restrictive” red blood cell transfusion threshold, a hemoglobin concentration <7 to 8 g/dL, has long been recommended for most hospitalized patients including anemic patients with stable cardiovascular disease (CVD). Although no threshold recommendation is given for acute coronary syndromes (ACSs), recent evidence suggests that “liberal” rather than “restrictive” transfusion strategies are associated with significantly improved safety for hospitalized patients with stable CVD and/or ACS. This finding suggests that previously available data were misinterpreted. Conclusions drawn from earlier transfusion trigger trials have been confounded by unintentional trial design and analysis flaws that have contributed to erroneous recommendations regarding the safety of a restrictive threshold. Subsequently, these conclusions have been incorporated into widely accepted guidelines and clinical practice. Management with a restrictive vs liberal transfusion strategy (<10 g/dL) increases the risk of new-onset ACS in patients with CVD by ∼2%. We estimate that since 2019, using hospital databases and a recent meta-analysis, this practice may have resulted in ∼700 excess ACS events per year in orthopedic surgical patients. Given these findings, transfusion practices in other clinical conditions, particularly those derived from similar transfusion trigger trials, should be questioned. Restrictive and liberal transfusion policies merit a general reconsideration. Rather than a single numerical transfusion trigger, transfusion therapy should be personalized. Consideration of an individual patient’s age, clinical status, and comorbidities is integral to transfusing. To avoid making similar errors, future trials of transfusion therapy should determine common practices before study inception and incorporate them as a usual-care “control” comparator arm into the trial design. Such studies should more reliably improve current transfusion practice.

Published
2024
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9. In a Canine Model of Septic Shock, Cardiomyopathy Occurs Independent of Catecholamine Surges and Cardiac Microvascular Ischemia

Author

Ford, Verity J., primary, Applefeld, Willard N., additional, Wang, Jeffrey, additional, Sun, Junfeng, additional, Solomon, Steven B., additional, Klein, Harvey G., additional, Feng, Jing, additional, Lertora, Juan, additional, Parizi-Torabi, Parizad, additional, Danner, Robert L., additional, Solomon, Michael A., additional, Chen, Marcus Y., additional, and Natanson, Charles, additional

Published
2024
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10. Cardiac Magnetic Resonance Studies in a Large Animal Model that Simulates the Cardiac Abnormalities of Human Septic Shock

Author

Ford, Verity J., primary, Applefeld, Willard N., additional, Wang, Jeffrey, additional, Sun, Junfeng, additional, Solomon, Steven B., additional, Sidenko, Stanislav, additional, Feng, Jing, additional, Sheffield, Cynthia, additional, Klein, Harvey G., additional, Yu, Zu-Xi, additional, Torabi-Parizi, Parizad, additional, Danner, Robert L., additional, Sachdev, Vandana, additional, Solomon, Michael A., additional, Chen, Marcus Y., additional, and Natanson, Charles, additional

Published
2024
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14. Contributors

Author

Altomare, Ivy, primary, Ansell, Jack E., additional, Arnold, Donald M., additional, Ataga, Kenneth I., additional, Bai, Yu, additional, Samuelson Bannow, Bethany T., additional, Bates, Shannon M., additional, Bauer, Kenneth A., additional, Berger, Jeffrey, additional, Brodsky, Robert A., additional, Chen, Junmei, additional, Chung, Dominic W., additional, Connolly, Gregory C., additional, Connelly-Smith, Laura S., additional, Crowther, Mark A., additional, Cucchiara, Brett, additional, Cunningham, Julia M., additional, Delaney, Meghan, additional, DeLoughery, Thomas G., additional, Di Paola, Jorge, additional, Escobar, Miguel A., additional, Favilla, Christopher G., additional, Freed, Jason, additional, Galanaud, Jean-Philippe, additional, Garcia, David A., additional, Gavriilaki, Eleni, additional, Hess, John R., additional, Holcomb, John B., additional, James, Andra H., additional, Jobe, Shawn M., additional, Kahn, Susan R., additional, Kasthuri, Raj S., additional, Kessler, Craig M., additional, Khorana, Alok A., additional, Kitchens, Craig S., additional, Klein, Harvey G., additional, Konkle, Barbara A., additional, Kruse-Jarres, Rebecca, additional, Kumar, Monisha, additional, Kuter, David J., additional, Langerak, Thomas, additional, Lawson, Janice W., additional, Leissinger, Cindy A., additional, Levi, Marcel, additional, Lisman, Ton, additional, López, José A., additional, Lottenberg, Richard, additional, Mandernach, Molly W., additional, Messé, Steven R., additional, Mithoowani, Siraj, additional, Moake, Joel L., additional, Moll, Stephan, additional, Murphy, Martina C., additional, Napolitano, Mariasanta, additional, Özpolat, H. Tahsin, additional, Ortel, Thomas L., additional, Pahl, Kristy, additional, Porte, Robert J., additional, Raffini, Leslie, additional, Rajasekhar, Anita, additional, Savji, Nazir, additional, Sood, Suman L., additional, Streiff, Michael B., additional, ten Cate, Hugo, additional, Van Gorp, Eric C.M., additional, Warkentin, Theodore E., additional, Wysokinska, Ewa, additional, Zimrin, Ann B., additional, and Zumberg, Marc, additional

Published
2019
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15. Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated.

Author

Ford, Verity J, Klein, Harvey G, Danner, Robert L, Applefeld, Willard N, Wang, Jeffrey, Cortes-Puch, Irene, Eichacker, Peter Q, and Natanson, Charles

Subjects
EXPERIMENTAL design, CLINICAL trials, MEDICAL care research, CRITICAL care medicine, RESEARCH funding, PATIENT safety
Abstract

Background: Comparative effectiveness research is meant to determine which commonly employed medical interventions are most beneficial, least harmful, and/or most costly in a real-world setting. While the objectives for comparative effectiveness research are clear, the field has failed to develop either a uniform definition of comparative effectiveness research or an appropriate set of recommendations to provide standards for the design of critical care comparative effectiveness research trials, spurring controversy in recent years. The insertion of non-representative control and/or comparator arm subjects into critical care comparative effectiveness research trials can threaten trial subjects' safety. Nonetheless, the broader scientific community does not always appreciate the importance of defining and maintaining critical care practices during a trial, especially when vulnerable, critically ill populations are studied. Consequently, critical care comparative effectiveness research trials sometimes lack properly constructed control or active comparator arms altogether and/or suffer from the inclusion of "unusual critical care" that may adversely affect groups enrolled in one or more arms. This oversight has led to critical care comparative effectiveness research trial designs that impair informed consent, confound interpretation of trial results, and increase the risk of harm for trial participants. Methods/Examples: We propose a novel approach to performing critical care comparative effectiveness research trials that mandates the documentation of critical care practices prior to trial initiation. We also classify the most common types of critical care comparative effectiveness research trials, as well as the most frequent errors in trial design. We present examples of these design flaws drawn from past and recently published trials as well as examples of trials that avoided those errors. Finally, we summarize strategies employed successfully in well-designed trials, in hopes of suggesting a comprehensive standard for the field. Conclusion: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Contributors

Author

Abdel-Wahab, Omar, primary, Abrahm, Janet L., additional, Adams, Sharon, additional, Adewoye, Adeboye H., additional, Allen, Carl, additional, Ambinder, Richard F., additional, Anasetti, Claudio, additional, Anastasi, John, additional, Anderson, Julia A., additional, Antin, Joseph H., additional, Antony, Aśok C., additional, Araten, David J., additional, Armand, Philippe, additional, Armstrong, Gillian, additional, Armstrong, Scott A., additional, Arnold, Donald M., additional, Artz, Andrew S., additional, Awan, Farrukh T., additional, Baglin, Trevor P., additional, Benson, Don M., additional, Benz, Edward J., additional, Berliner, Nancy, additional, Bhagat, Govind, additional, Bhardwaj, Nina, additional, Bhatia, Ravi, additional, Bhatia, Smita, additional, Bhatt, Mihir D., additional, Bhatt, Vijaya Raj, additional, Bitan, Menachem, additional, Blinderman, Craig D., additional, Bollard, Catherine M., additional, Braun, Benjamin S., additional, Brenner, Malcolm K., additional, Brittenham, Gary M., additional, Brodsky, Robert A., additional, Brown, Myles, additional, Broxmeyer, Hal E., additional, Brummel-Ziedins, Kathleen, additional, Brunner, Andrew M., additional, Buadi, Francis K., additional, Burkhardt, Birgit, additional, Burns, Melissa, additional, Byrd, John C., additional, Caimi, Paolo F., additional, Caligiuri, Michael A., additional, Canavan, Michelle, additional, Cantor, Alan B., additional, Carcao, Manuel, additional, Carroll, Michael C., additional, Carty, Shannon A., additional, Castillo, Jorge J., additional, Chan, Anthony K.C., additional, Chapin, John, additional, Chiu, April, additional, Chute, John P., additional, Clark, David B., additional, Coates, Thomas D., additional, Cogle, Christopher R., additional, Connell, Nathan T., additional, Cooke, Elizabeth, additional, Cooley, Sarah, additional, Corradini, Paolo, additional, Creager, Mark A., additional, Creger, Richard J., additional, Cromwell, Caroline, additional, Crowther, Mark A., additional, Cushing, Melissa M., additional, Cutler, Corey, additional, Dang, Chi V., additional, Danial, Nika N., additional, Dave, Sandeep S., additional, DeCaprio, James A., additional, Dinauer, Mary C., additional, Dinner, Shira, additional, Diz-Küçükkaya, Reyhan, additional, Dodd, Roger Y., additional, Donato, Michele L., additional, Dorshkind, Kenneth, additional, Dotti, Gianpietro, additional, Dror, Yigal, additional, Dunleavy, Kieron, additional, Dvorak, Christopher C., additional, Ebert, Benjamin L., additional, Eck, Michael J., additional, Eikelboom, John W., additional, Epperla, Narendranath, additional, Ershler, William B., additional, Evans, William E., additional, Faderl, Stefan, additional, Ferrara, James L.M., additional, Filipovich, Alexandra Hult, additional, Fischer, Martin, additional, Fredenburgh, James C., additional, Friedman, Kenneth D., additional, Fuchs, Ephraim, additional, Fuller, Stephen J., additional, Gailani, David, additional, Galipeau, Jacques, additional, Gallagher, Patrick G., additional, Ganapathi, Karthik A., additional, Gardner, Lawrence B., additional, Gee, Adrian P., additional, Gerson, Stanton L., additional, Gertz, Morie A., additional, Giardina, Patricia J., additional, Gibson, Christopher J., additional, Golan, Karin, additional, Golub, Todd R., additional, Gonzales, Matthew J., additional, Gotlib, Jason, additional, Gottschalk, Stephen, additional, Grant, Marianne A., additional, Graubert, Timothy A., additional, Gregg, Xylina T., additional, Gribben, John G., additional, Gross, Dawn M., additional, Gruber, Tanja A., additional, Guitart, Joan, additional, Gurbuxani, Sandeep, additional, Gur-Cohen, Shiri, additional, Gutierrez, Alejandro, additional, Hamadani, Mehdi, additional, Hari, Parameswaran N., additional, Hartwig, John H., additional, Hayman, Suzanne R., additional, Hayward, Catherine P.M., additional, Hebbel, Robert P., additional, Heslop, Helen E., additional, Hillis, Christopher, additional, Hillyer, Christopher D., additional, Ho, Karin, additional, Hockenbery, David M., additional, Hoffman, Ronald, additional, Hogg, Kerstin E., additional, Holtan, Shernan G., additional, Horny, Hans-Peter, additional, Hsu, Yen-Michael S., additional, Hunter, Zachary R., additional, Huntington, James A., additional, Iancu-Rubin, Camelia, additional, Iqbal, Ali, additional, Isenman, David E., additional, Israels, Sara J., additional, Italiano, Joseph E., additional, Jaffe, Elaine S., additional, Jaffer, Iqbal H., additional, Jagannath, Sundar, additional, Jäger, Ulrich, additional, Jain, Nitin, additional, James, Paula, additional, Jeha, Sima, additional, Jordan, Michael B., additional, Josephson, Cassandra D., additional, Jung, Moonjung, additional, Kager, Leo, additional, Kambayashi, Taku, additional, Kanakry, Jennifer A., additional, Kantarjian, Hagop M., additional, Kaplan, Jason, additional, Karafin, Matthew S., additional, Karsan, Aly, additional, Kaufman, Randal J., additional, Kaufman, Richard M., additional, Keller, Frank G., additional, Kelly, Kara M., additional, Kessler, Craig M., additional, Key, Nigel S., additional, Keyzner, Alla, additional, Khandoga, Alexander G., additional, Khanna-Gupta, Arati, additional, Khatib-Massalha, Eman, additional, Klein, Harvey G., additional, Knoechel, Birgit, additional, Kollet, Orit, additional, Konkle, Barbara A., additional, Kontoyiannis, Dimitrios P., additional, Koreth, John, additional, Koretzky, Gary A., additional, Kotecha, Dipak, additional, Kremyanskaya, Marina, additional, Kumari, Anju, additional, Kuzel, Timothy M., additional, Küppers, Ralf, additional, Lacy, Martha Q., additional, Ladas, Elana, additional, Landier, Wendy, additional, Lapid, Kfir, additional, Lapidot, Tsvee, additional, Larson, Peter J., additional, Levi, Marcel, additional, Lewis, Russell E., additional, Liebman, Howard A., additional, Lillicrap, David, additional, Lim, Wendy, additional, Lin, Judith C., additional, Lindblad, Robert, additional, Lip, Gregory Y.H., additional, Little, Jane A., additional, Lohr, Jens G., additional, López, José A., additional, Luscinskas, Francis W., additional, Maciejewski, Jaroslaw P., additional, Majhail, Navneet S., additional, Manches, Olivier, additional, Mandle, Robert J., additional, Mann, Kenneth G., additional, Manno, Catherine S., additional, Marcogliese, Andrea N., additional, Mariani, Guglielmo, additional, Marincola, Francesco M., additional, Mascarenhas, John, additional, Massberg, Steffen, additional, McEver, Rodger P., additional, McGrath, Emer, additional, McKinney, Matthew S., additional, Mehta, Rohtesh S., additional, Mentzer, William C., additional, Merlini, Giampaolo, additional, Merryman, Reid, additional, Michel, Marc, additional, Migliaccio, Anna Rita, additional, Miller, Jeffrey S., additional, Mims, Martha P., additional, Mondoro, Traci Heath, additional, Moorehead, Paul, additional, Muniz, Luciana R., additional, Munshi, Nikhil C., additional, Najfeld, Vesna, additional, Nayak, Lalitha, additional, Nazy, Ishac, additional, Neff, Anne T., additional, Ness, Paul M., additional, Notarangelo, Luigi D., additional, O'Brien, Sarah H., additional, O'Connor, Owen A., additional, O'Donnell, Martin, additional, Olson, Amanda, additional, Orkin, Stuart H., additional, Pai, Menaka, additional, Pai, Sung-Yun, additional, Paidas, Michael, additional, Panch, Sandhya R., additional, Pande, Reena L., additional, Papayannopoulou, Thalia, additional, Parikh, Rahul, additional, Petersdorf, Effie W., additional, Peterson, Shane E., additional, Pittaluga, Stefania, additional, Ponce, Doris M., additional, Popolo, Laura, additional, Prchal, Josef T., additional, Pui, Ching-Hon, additional, Puigserver, Pere, additional, Rak, Janusz, additional, Ramos, Carlos A., additional, Rand, Jacob H., additional, Rand, Margaret L., additional, Rao, Dinesh S., additional, Ravandi, Farhad, additional, Rawlings, David J., additional, Reddy, Pavan, additional, Reding, Mark T., additional, Reiter, Andreas, additional, Rice, Lawrence, additional, Riese, Matthew J., additional, Ritchey, Arthur Kim, additional, Roberts, David J., additional, Roman, Elizabeth, additional, Rooney, Cliona M., additional, Rosen, Steven T., additional, Rosenthal, David S., additional, Rossmann, Marlies P., additional, Rot, Antal, additional, Rowley, Scott D., additional, Rubnitz, Jeffrey E., additional, Rydz, Natalia, additional, Salama, Mohamed E., additional, Sauk, Steven, additional, Saunthararajah, Yogen, additional, Savage, William, additional, Scadden, David, additional, Schaefer, Kristen G., additional, Schiffman, Fred, additional, Schneidewend, Robert, additional, Schrier, Stanley L., additional, Schuchman, Edward H., additional, Scullion, Bridget Fowler, additional, Selvaggi, Kathy J., additional, Senoo, Keitaro, additional, Shaheen, Montaser, additional, Shaz, Beth H., additional, Shelburne, Samuel A., additional, Shpall, Elizabeth J., additional, Shurin, Susan B., additional, Siegal, Deborah, additional, Silberstein, Leslie E., additional, Silberstein, Lev, additional, Silverstein, Roy L., additional, Sloan, Steven R., additional, Smith, Franklin O., additional, Smith, James W., additional, Smith, Katy, additional, Steensma, David P., additional, Steinberg, Martin H., additional, Stock, Wendy, additional, Storry, Jill R., additional, Stramer, Susan L., additional, Strauss, Ronald G., additional, Stroncek, David F., additional, Taylor, Justin, additional, Thota, Swapna, additional, Treon, Steven P., additional, Tulpule, Anil, additional, Valdes, Roberto Ferro, additional, Valent, Peter, additional, Vedantham, Suresh, additional, Vercellotti, Gregory M., additional, Verneris, Michael R., additional, Vichinsky, Elliott P., additional, von Andrian, Ulrich H., additional, Vose, Julie M., additional, Wagner, Andrew J., additional, Wang, Ena, additional, Wang, Jia-huai, additional, Warkentin, Theodore E., additional, Wasserstein, Melissa P., additional, Webster, Ann, additional, Weisdorf, Daniel J., additional, Weitz, Jeffrey I., additional, Westhoff, Connie M., additional, Wheeler, Allison P., additional, Widick, Page, additional, Wiley, James S., additional, William, Basem M., additional, Williams, David A., additional, Wilson, Wyndham H., additional, Wolfe, Joanne, additional, Wolgast, Lucia R., additional, Wood, Deborah, additional, Wu, Jennifer, additional, Yahalom, Joachim, additional, Yee, Donald L., additional, Younes, Anas, additional, Young, Neal S., additional, and Zeller, Michelle P., additional

Published
2018
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21. Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia

Author

Cortés-Puch, Irene, Wang, Dong, Sun, Junfeng, Solomon, Steven B., Remy, Kenneth E., Fernandez, Melinda, Feng, Jing, Kanias, Tamir, Bellavia, Landon, Sinchar, Derek, Perlegas, Andreas, Solomon, Michael A., Kelley, Walter E., Popovsky, Mark A., Gladwin, Mark T., Kim-Shapiro, Daniel B., Klein, Harvey G., and Natanson, Charles

Published
2014
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41. Mechanistic insights into cell-free hemoglobin-induced injury during septic shock

Author

Wang, Jeffrey, primary, Applefeld, Willard N., additional, Sun, Junfeng, additional, Solomon, Steve B., additional, Feng, Jing, additional, Couse, Zoe G., additional, Risoleo, Thomas F., additional, Danner, Robert L., additional, Tejero, Jesús, additional, Lertora, Juan, additional, Alipour, Elmira, additional, Basu, Swati, additional, Sachdev, Vandana, additional, Kim-Shapiro, Daniel B., additional, Gladwin, Mark T., additional, Klein, Harvey G., additional, and Natanson, Charles, additional

Published
2021
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44. Contributors

Author

Aird, William C., primary, Ansell, Jack E., additional, Ataga, Kenneth I., additional, Bai, Yu, additional, Bates, Shannon M., additional, Becker, Richard C., additional, Block, Peter C., additional, Bolan, Charles D., additional, Chen, Junmei, additional, Chung, Dominic W., additional, Connolly, Gregory C., additional, Crowther, Mark, additional, Cucchiara, Brett, additional, Delaney, Meghan, additional, DeLoughery, Thomas G., additional, Di Paola, Jorge, additional, Escobar, Miguel A., additional, Fogarty, Patrick F., additional, Galanaud, Jean-Philippe, additional, George, James N., additional, Goldhaber, Samuel Z., additional, Green, David, additional, Heit, John A., additional, Hess, John R., additional, Holcomb, John B., additional, James, Andra H., additional, Jobe, Shawn, additional, Jong, Eefje, additional, Kessler, Craig M., additional, Khan, Susan R., additional, Khorana, Alok A., additional, Kitchens, Craig S., additional, Klein, Harvey G., additional, Konkle, Barbara A., additional, Koprivnikar, Jamie, additional, Kruse-Jarres, Rebecca, additional, Kumar, Monisha, additional, Kunio, Nicholas R., additional, Kuter, David J., additional, Lawson, Janice W., additional, Leissinger, Cindy A., additional, Levi, Marcel, additional, Linenberger, Michael, additional, Lisman, Ton, additional, Lopez, Jose A., additional, Lottenberg, Richard, additional, Dog, Tieraona Low, additional, Macik, B. Gail, additional, Mandernach, Molly W., additional, Marder, Victor J., additional, Markham, Merry-Jennifer, additional, Moake, Joel L., additional, Moll, Stephan, additional, Morrison-McKell, Travis, additional, Ortel, Thomas L., additional, Patriquin, Christopher, additional, Porte, Robert J., additional, Raffini, Leslie, additional, Rajasakhar, Anita, additional, Rand, Jacob H., additional, Rick, Margaret E., additional, Roberts, Harold R., additional, Rubin, Lewis J., additional, Schreiber, Martin A., additional, Sood, Suman, additional, Streiff, Michael B., additional, Suwanawiboon, Bundarika, additional, Cate, Hugo ten, additional, Van, Eric C.M., additional, Vemulapalli, Sreekanth, additional, Warkentin, Theodore E., additional, Wolgast, Lucia R., additional, Zimrin, Ann B., additional, and Zumberg, Marc, additional

Published
2013
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46. Contributors

Author

Albert, Paul S., primary, Bartlett, Olivia T., additional, Bates, Angela, additional, Bluemke, David A., additional, Borkowf, Craig B., additional, Burklow, John T., additional, Lowell Butler, Susan, additional, Califf, Robert M., additional, Chan, Leighton, additional, Cimino, James J., additional, Colbert, Melissa C., additional, Dankwa-Mullan, Irene, additional, Dixon, Dennis O., additional, Emanuel, Ezekiel J., additional, Fleisher, Thomas A., additional, Freeman, Bradley D., additional, Friedman, Lawrence M., additional, Gahl, William A., additional, Gallin, Elaine K., additional, Gallin, John I., additional, Gerber, Lynn H., additional, Goldstein, Bruce, additional, Gottesman, Michael M., additional, Grady, Christine, additional, Hart, P. Suzanne, additional, Hastings, Clare, additional, Henderson, David K., additional, Ide, Nicholas C., additional, Lee Johnson, Laura, additional, Kallman Price, Jillian, additional, Karp, Barbara I., additional, Kelty, Miriam, additional, Klein, Harvey G., additional, Korf, Bruce R., additional, Kost, Rhonda G., additional, Kvochak, Patricia A., additional, Lee, Laura M., additional, Lertora, Juan J.L., additional, Liu, Nianjun, additional, Liu, Songtao, additional, Markello, Thomas C., additional, Matula, Margaret A., additional, McGarey, Patrick, additional, Murray, Patrick R., additional, Natanson, Charles, additional, Nussenblatt, Robert B., additional, Ognibene, Frederick P., additional, Olopade, Christopher O., additional, Olopade, Olufunmilayo I., additional, Olugbile, Sope, additional, Pinn, Vivian W., additional, Pitt, Karen E., additional, Proschan, Michael A., additional, Remaley, Alan T., additional, Resnik, Denise T., additional, Louis Rhee, Kyu Bak, additional, Rosenfeld, Stephen J., additional, Shaw, Pamela A., additional, Shih, Joanna H., additional, Skubitz, Amy P.N., additional, Speers, Marjorie, additional, St. Germain, Diane C., additional, Stoney, Catherine M., additional, Straus, Stephen E., additional, Sun, Junfeng, additional, Sung, Nancy S., additional, Tse, Tony, additional, Vanevski, Konstantina M., additional, Wichman, Alison, additional, Williams, Rebecca J., additional, Yessis, Jennifer, additional, Yetter, Robert A., additional, Zarin, Deborah A., additional, and Zoon, Kathryn C., additional

Published
2012
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