Search

Your search keyword '"Klawe, Jacek J."' showing total 151 results
Start Over Author "Klawe, Jacek J."
151 results on '"Klawe, Jacek J."'

2. Frequency and severity of autonomic dysfunction assessed by objective hemodynamic responses and patient-reported symptoms in individuals with myasthenia gravis.

Author

Zawadka-Kunikowska, Monika, Cieślicka, Mirosława, Klawe, Jacek J., Tafil-Klawe, Małgorzata, Kaźmierczak, Wojciech, and Rzepiński, Łukasz

Abstract

Introduction: Myasthenia gravis (MG), a rare autoimmune disorder, poses diagnostic and management challenges, with increasing incidence in Europe and significant impact on patient quality of life. Despite prevalent autonomic symptoms, comprehensive assessments integrating subjective and objective measures are lacking. We aimed to investigate the prevalence and severity of autonomic dysfunction in patients with MG and healthy controls (HCs). Materials and methods: We used beat-to-beat hemodynamic responses during standardized autonomic function tests (AFTs) and the Composite Autonomic Symptom Score 31 (COMPASS-31) questionnaire. Study participants including, 53 patients with MG and 30 age- and sex matched HCs underwent standardized cardiovascular AFTs and completed the COMPASS-31 questionnaire. Patients were categorized into Non-CAN and CAN groups based on their Cardiovascular Autonomic Neuropathy (CAN) status, as evaluated using the Composite Autonomic Scoring Scale (CASS). During the AFTs, cardiovascular parameters including heart rate, systolic blood pressure (BP), diastolic BP, mean BP, stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) were measured. Results: Twenty patients with MG (38%) exhibited mild CAN (CASS =2) with a median total CASS score of 1.00 and CASS 0.00 in HCs. Adrenergic impairment was observed in 27 patients (52%), with 13 patients (24.5%) exhibiting longer pressure recovery time after Valsalva maneuver (VM). Cardiovagal impairment was evident in 71% of patients, with abnormal results observed in 39.6% for the deep breathing test and 56.6% for the VM. CAN MG showed worse scores than HCs for the total COMPASS-31 (p < 0.001), orthostatic (OI) (p < 0.001), secretomotor (p = 0.004), and pupillomotor domains (p = 0.004). Total COMPASS-31 and OI scores were correlated with worse disease outcomes (disease duration, severity), hemodynamic parameter changes (SV, CO, TPR) during phase II late of VM, and with changes (tilt-supine) in systolic BP, diastolic BP, mean BP, TPR during head-up-tilt test, but not with CASS score. Conclusion: Our findings demonstrate mild cardiovascular autonomic impairment in adrenergic and cardiovagal domains in patients with MG. Additionally, patient-reported autonomic symptoms correlated with hemodynamic changes during AFTs and worse disease outcomes and not with the grade of autonomic abnormalities. Incorporating beat-to-beat hemodynamics during AFTs may offer further insights for characterizing orthostatic intolerance symptoms in MG group. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Campylobacter in wintering great tits Parus major in Poland

Author

Tryjanowski, Piotr, Nowakowski, Jacek J., Indykiewicz, Piotr, Andrzejewska, Małgorzata, Śpica, Dorota, Sandecki, Rafał, Mitrus, Cezary, Goławski, Artur, Dulisz, Beata, Dziarska, Joanna, Janiszewski, Tomasz, Minias, Piotr, Świtek, Stanisław, Tobolka, Marcin, Włodarczyk, Radosław, Szczepańska, Bernadeta, and Klawe, Jacek J.

Published
2020
Full Text
View/download PDF

11. Defining cardiac adaptations and safety of endurance training in patients with m.3243A>G-related mitochondrial disease

Author

Bates, Matthew G.D., Newman, Jane H., Jakovljevic, Djordje G., Hollingsworth, Kieren G., Alston, Charlotte L., Zalewski, Pawel, Klawe, Jacek J., Blamire, Andrew M., MacGowan, Guy A., Keavney, Bernard D., Bourke, John P., Schaefer, Andrew, McFarland, Robert, Newton, Julia L., Turnbull, Douglass M., Taylor, Robert W., Trenell, Michael I., and Gorman, Gráinne S.

Published
2013
Full Text
View/download PDF

18. Relationship between cardiopulmonary, mitochondrial and autonomic nervous system function improvement after an individualised activity programme upon chronic fatigue syndrome patients

Author

Kujawski, Sławomir, Cossington, Jo, Słomko, Joanna, Zawadka-Kunikowska, Monika, Tafil-Klawe, Małgorzata, Klawe, Jacek J., Buszko, Katarzyna, Jakovljevic, Djordje G., Kozakiewicz, Mariusz, Morten, Karl J., Dawes, Helen, Strong, James W.L., Murovska, Modra, Oosterwijck, Jessica Van, Estévez López, Fer, Newton, Julia L., Hodges, Lynette, Zalewski, Paweł, Kujawski, Sławomir, Cossington, Jo, Słomko, Joanna, Zawadka-Kunikowska, Monika, Tafil-Klawe, Małgorzata, Klawe, Jacek J., Buszko, Katarzyna, Jakovljevic, Djordje G., Kozakiewicz, Mariusz, Morten, Karl J., Dawes, Helen, Strong, James W.L., Murovska, Modra, Oosterwijck, Jessica Van, Estévez López, Fer, Newton, Julia L., Hodges, Lynette, and Zalewski, Paweł

Abstract

Background: The therapeutic effects of exercise from structured activity programmes have recently been questioned; as a result, this study examines the impact of an Individualised Activity Program (IAP) on the relationship with cardiovascular, mitochondrial and fatigue parameters. Methods: Chronic fatigue syndrome (CFS) patients were assessed using Chalder Fatigue Questionnaire (CFQ), Fatigue Severity Score (FSS) and the Fatigue Impact Scale (FIS). VO2peak, VO2submax and heart rate (HR) were assessed using cardiopulmonary exercise testing. Mfn1 and Mfn2 levels in plasma were assessed. A Task Force Monitor was used to assess ANS functioning in supine rest and in response to the Head-Up Tilt Test (HUTT). Results: Thirty-four patients completed 16 weeks of the IAP. The CFQ, FSS and FIS scores decreased significantly along with a significant increase in Mfn1 and Mfn2 levels (p = 0.002 and p = 0.00005, respectively). The relationships between VO2 peak and Mfn1 increase in response to IAP (p = 0.03) and between VO2 at anaerobic threshold and ANS response to the HUTT (p = 0.03) were noted. Conclusions: It is concluded that IAP reduces fatigue and improves functional performance along with changes in autonomic and mitochondrial function. However, caution must be applied as exercise was not well tolerated by 51% of patients.

Published
2021

22. Autonomic Phenotypes in Chronic Fatigue Syndrome (CFS) Are Associated with Illness Severity: A Cluster Analysis

Author

Słomko, Joanna, primary, Estévez-López, Fernando, additional, Kujawski, Sławomir, additional, Zawadka-Kunikowska, Monika, additional, Tafil-Klawe, Małgorzata, additional, Klawe, Jacek J., additional, Morten, Karl J., additional, Szrajda, Justyna, additional, Murovska, Modra, additional, Newton, Julia L., additional, and Zalewski, Paweł, additional

Published
2020
Full Text
View/download PDF

23. Importance of fatiguing, overtraining and chronic fatigue in athletes

Author

Piesik, Adam, Dryja, Monika, Zawadka-Kunikowska, Monika, Slomko, Joanna, Kozakiewicz, Mariusz, Tafil‑Klawe, Małgorzata, Klawe, Jacek J., and Zalewski, Paweł

Subjects
lcsh:Sports, lcsh:GV557-1198.995, lcsh:R, lcsh:Medicine, overtraining syndrome, elite sportsmen, supercompensation, lcsh:L, lcsh:Education
Abstract

Piesik Adam, Dryja Monika, Zawadka-Kunikowska Monika, Slomko Joanna, Kozakiewicz Mariusz, Tafil‑Klawe Małgorzata, Klawe Jacek J., Zalewski Paweł. Importance of fatiguing, overtraining and chronic fatigue in athletes. Journal of Education, Health and Sport. 2017;7(9):203-216. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.893319 http://ojs.ukw.edu.pl/index.php/johs/article/view/4829 https://pbn.nauka.gov.pl/sedno-webapp/works/831622 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.08.2017. Revised: 10.09.2017. Accepted: 10.09.2017. Importance of fatiguing, overtraining and chronic fatigue in athletes Adam Piesik1, Monika Dryja1, Monika Zawadka-Kunikowska1, Joanna Slomko1, Mariusz Kozakiewicz3, Małgorzata Tafil-Klawe2, Jacek J. Klawe1, Paweł Zalewski1 1 Department of Hygiene, Epidemiology, and Ergonomics Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy UMK w Toruniu, Polska 2 Department of Physiology Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy UMK w Toruniu, Polska 3 Department of Chemistry of Foodstuffs Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy UMK w Toruniu, Polska Correspondence: Adam Piesik, Department of Ergonomics and Exercise Physiology, ul. M. Curie Skłodowskiej 9, 85-094 Bydgoszcz, adam_piesik@cm.umk.pl, tel./fax 52 585-35-89 Abstract Each training that requires achieving a higher heart rate limit and/or increased concentration in time may cause fatigue, considered to be a natural defence mechanism of a body. In the case of excessive fatigue and insufficient time designated for rest and regeneration, an overtraining syndrome (OTS) may develop. The main symptom of overtraining is increased fatigue that fails to become reversed in normal conditions of regeneration. Although authors are familiar with the overtraining syndrome and associated symptoms, as of today no diagnostic tool has been developed that may form a basis for a final diagnosis, and the diagnosis itself is frequently based on a subjective assessment of the athlete. Possible causes of the band overtraining syndrome are disorders of sodium, inflammatory processes resulting from physical activity and / or disorders of the autonomic nervous system. Key words: OTS, elite sportsmen, supercompensation

Published
2017

25. Campylobacter in wintering great tits Parus major in Poland

Author

Tryjanowski, Piotr, primary, Nowakowski, Jacek J., additional, Indykiewicz, Piotr, additional, Andrzejewska, Małgorzata, additional, Śpica, Dorota, additional, Sandecki, Rafał, additional, Mitrus, Cezary, additional, Goławski, Artur, additional, Dulisz, Beata, additional, Dziarska, Joanna, additional, Janiszewski, Tomasz, additional, Minias, Piotr, additional, Świtek, Stanisław, additional, Tobolka, Marcin, additional, Włodarczyk, Radosław, additional, Szczepańska, Bernadeta, additional, and Klawe, Jacek J., additional

Published
2019
Full Text
View/download PDF

30. The impact of total sleep deprivation upon cognitive functioning in firefighters

Author

Kujawski,Sławomir, Słomko,Joanna, Tafil-Klawe,Małgorzata, Zawadka-Kunikowska,Monika, Szrajda,Justyna, Newton,Julia L, Zalewski,Paweł, Klawe,Jacek J, Kujawski,Sławomir, Słomko,Joanna, Tafil-Klawe,Małgorzata, Zawadka-Kunikowska,Monika, Szrajda,Justyna, Newton,Julia L, Zalewski,Paweł, and Klawe,Jacek J

Abstract

Sławomir Kujawski,1 Joanna Słomko,1 Małgorzata Tafil-Klawe,2 Monika Zawadka-Kunikowska,1 Justyna Szrajda,1 Julia L Newton,3 Paweł Zalewski,1 Jacek J Klawe1 1Department of Hygiene, Epidemiology and Ergonomics, Nicolaus Copernicus University, Toruń, Poland; 2Department of Human Physiology, Nicolaus Copernicus University, Toruń, Poland; 3Institute for Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle-upon-Tyne, UK Introduction: Firefighters as a profession are required to maintain high levels of attention for prolonged periods. However, total sleep deprivation (TSD) could influence negatively upon performance, particularly when the task is prolonged and repetitive. Purpose: The aim of this study is to examine the influence of TSD on cognitive functioning in a group of firefighters. Subjects and methods: Sixty volunteers who were active male fire brigade officers were examined with a computerized battery test that consisted of simple reaction time (SRT) (repeated three times), choice reaction time, visual attention test, and delayed matching to sample. Six series of measurements were undertaken over a period of TSD. Results: Performance in the second attempt in SRT test was significantly worse in terms of increased number of errors and, consequently, decreased number of correct responses during TSD. In contrast, the choice reaction time number of correct responses as well as the visual attention test reaction time for all and correct responses significantly improved compared to initial time points. Conclusion: The study has confirmed that subjects committed significantly more errors and, consequently, noted a smaller number of correct responses in the second attempt of SRT test. However, the remaining results showed reversed direction of TSD influence. TSD potentially leads to worse performance in a relatively easy task in a group of firefighters. Errors during repetitive tasks in firefighting routines could potenti

Published
2018

32. Effects of 3-months sitting callisthenic balance and resistance exercise on aerobic capacity, aortic stiffness and body composition in healthy older participants. Randomized Controlled Trial

Author

Kujawski, Sławomir, primary, Kujawska, Agnieszka, additional, Gajos, Małgorzata, additional, Klawe, Jacek J., additional, Tafil-Klawe, Małgorzata, additional, Mądra-Gackowska, Katarzyna, additional, Stankiewicz, Błażej, additional, Newton, Julia L., additional, Kędziora-Kornatowska, Kornelia, additional, and Zalewski, Paweł, additional

Published
2018
Full Text
View/download PDF

44. Variable contribution of functional prey groups in diets reveals inter- and intraspecific differences in faecal concentrations of essential and non-essential elements in three sympatric avian aerial insectivores: A re-assessment of usefulness of bird faeces in metal biomonitoring

Author

Orłowski, Grzegorz, primary, Kamiński, Piotr, additional, Karg, Jerzy, additional, Baszyński, Jędrzej, additional, Szady-Grad, Małgorzata, additional, Koim-Puchowska, Beata, additional, and Klawe, Jacek J., additional

Published
2015
Full Text
View/download PDF

46. Prevalence, Virulence, and Antimicrobial Resistance ofCampylobacter jejuniandCampylobacter coliin White StorkCiconia ciconiain Poland

Author

Szczepańska, Bernadeta, primary, Kamiński, Piotr, additional, Andrzejewska, Małgorzata, additional, Śpica, Dorota, additional, Kartanas, Edmund, additional, Ulrich, Werner, additional, Jerzak, Leszek, additional, Kasprzak, Mariusz, additional, Bocheński, Marcin, additional, and Klawe, Jacek J., additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results