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3 results on '"Klaus Kreuels"'

1. New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing

Author

Andreas Hoffmann, Holger Leonards, Nora Tobies, Ludwig Pongratz, Klaus Kreuels, Franziska Kreimendahl, Christian Apel, Martin Wehner, and Nadine Nottrodt

Subjects
Biochemistry, QD415-436
Abstract

Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization.

Published
2017
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2. Utilizing direct-initiation of thiols for photoinitiator-free stereolithographic 3D printing of mechanically stable scaffolds

Author

Klaus Kreuels, David Bosma, Nadine Nottrodt, Arnold Gillner, and Publica

Subjects
photochemistry, scaffolds, ddc:570, microstructures, Biomedical Engineering, Medicine, Laser, Thiol-ene, 3D printing, stereolithography
Abstract

Current directions in biomedical engineering 7(2), 847-850 (2021). doi:10.1515/cdbme-2021-2216, Published by De Gruyter, Berlin

Published
2021
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3. On the incorporation of functionalities into hydroxyapatite capsules

Author

Birte Varnholt, Alexander Böker, Bernd Michael Liebeck, Klaus Kreuels, Thomas Subkowski, Marina Juliane Richter, and Alexander Schulz

Subjects
Waiting time, Flexibility (engineering), Materials science, Hydrophobin, Emulsion, Biomedical Engineering, General Materials Science, Nanotechnology, General Chemistry, General Medicine, Microreactor, Drug transport, Biomineralization
Abstract

Nature is capable of building materials with tailor-made properties under ambient conditions for specific applications. We apply some of the basic building principles of biomineralization in this paper: we stabilize an oil/water emulsion with the protein hydrophobin and mineralize this emulsion, resulting in hollow mineral capsules. The use of an emulsion as a liquid template enables precise size control over the final capsules. We mimic nature by using complexing agents and surfactants as additives to alter the properties of the growing mineral. We also modify the mineral itself by addition of different cations. Furthermore, we show the inclusion of silver into the capsules. This should add antibacterial properties to the capsules and shows exemplarily that catalytically active metals can be included. While the manual process needs numerous working steps and long waiting times, we ease the whole process by automation and use phosphatases to shorten synthesis time. Our experiments show the flexibility and adaptability of our system, making it an ideal platform for various possible applications such as drug transport and especially as microreactors.

Published
2020

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