12 results on '"Kjelgaard M"'
Search Results
2. Characterizing autonomic response to arousing visual-auditory multi-modal task in Autism Spectrum Disorder (ASD)
- Author
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Cavinato, L., primary, Cardinaux, A., additional, Jain, K., additional, Jamal, W., additional, Kjelgaard, M., additional, Sinha, P., additional, and Barbieri, R., additional
- Published
- 2019
- Full Text
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3. Developmental change in predictive motor abilities.
- Author
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Park SW, Cardinaux A, Crozier D, Russo M, Kjelgaard M, Sinha P, and Sternad D
- Abstract
Prediction is critical for successful interactions with a dynamic environment. To test the development of predictive processes over the life span, we designed a suite of interceptive tasks implemented as interactive video games. Four tasks involving interactions with a flying ball with titrated challenge quantified spatiotemporal aspects of prediction. For comparison, reaction time was assessed in a matching task. The experiments were conducted in a museum, where over 400 visitors across all ages participated, and in a laboratory with a focused age group. Results consistently showed that predictive ability improved with age to reach adult level by age 12. In contrast, reaction time continued to decrease into late adolescence. Inter-task correlations revealed that the tasks tested different aspects of predictive processes. This developmental progression complements recent findings on cerebellar and cortical maturation. Additionally, these results can serve as normative data to study predictive processes in individuals with neurodevelopmental conditions., Competing Interests: The authors declare no competing interests., (© 2023 The Author(s).)
- Published
- 2023
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4. Altered engagement of the speech motor network is associated with reduced phonological working memory in autism.
- Author
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O'Brien AM, Perrachione TK, Wisman Weil L, Sanchez Araujo Y, Halverson K, Harris A, Ostrovskaya I, Kjelgaard M, Kenneth Wexler, Tager-Flusberg H, Gabrieli JDE, and Qi Z
- Subjects
- Child, Humans, Speech, Memory, Short-Term physiology, Linguistics, Autistic Disorder diagnostic imaging, Stuttering
- Abstract
Nonword repetition, a common clinical measure of phonological working memory, involves component processes of speech perception, working memory, and speech production. Autistic children often show behavioral challenges in nonword repetition, as do many individuals with communication disorders. It is unknown which subprocesses of phonological working memory are vulnerable in autistic individuals, and whether the same brain processes underlie the transdiagnostic difficulty with nonword repetition. We used functional magnetic resonance imaging (fMRI) to investigate the brain bases for nonword repetition challenges in autism. We compared activation during nonword repetition in functional brain networks subserving speech perception, working memory, and speech production between neurotypical and autistic children. Autistic children performed worse than neurotypical children on nonword repetition and had reduced activation in response to increasing phonological working memory load in the supplementary motor area. Multivoxel pattern analysis within the speech production network classified shorter vs longer nonword-repetition trials less accurately for autistic than neurotypical children. These speech production motor-specific differences were not observed in a group of children with reading disability who had similarly reduced nonword repetition behavior. These findings suggest that atypical function in speech production brain regions may contribute to nonword repetition difficulties in autism., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2023
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5. Reduced Sensory Habituation in Autism and Its Correlation with Behavioral Measures.
- Author
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Jamal W, Cardinaux A, Haskins AJ, Kjelgaard M, and Sinha P
- Subjects
- Child, Cognition, Electroencephalography, Habituation, Psychophysiologic, Humans, Autism Spectrum Disorder, Autistic Disorder
- Abstract
Autism is strongly associated with sensory processing difficulties. We investigate sensory habituation, given its relevance for understanding important phenotypic traits like hyper- and hypo-sensitivities. We collected electroencephalography data from 22 neuro-typical(NT) and 13 autistic(ASD) children during the presentation of visual and auditory sequences of repeated stimuli. Our data show that the ASD children have significantly reduced habituation relative to the NT children for both auditory and visual stimuli. These results point to impaired habituation as a modality-general phenomenon in ASD. Additionally, the rates of habituation are correlated with several clinical scores associated with competence along diverse phenotypic dimensions. These data suggest that the sensory difficulties in autism are likely to be associated with reduced habituation and are related to clinical symptomology., (© 2020. Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2021
- Full Text
- View/download PDF
6. Autonomic and Electrophysiological Evidence for Reduced Auditory Habituation in Autism.
- Author
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Gandhi TK, Tsourides K, Singhal N, Cardinaux A, Jamal W, Pantazis D, Kjelgaard M, and Sinha P
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- Adolescent, Case-Control Studies, Child, Female, Galvanic Skin Response, Humans, Magnetoencephalography, Male, Young Adult, Autistic Disorder physiopathology, Habituation, Psychophysiologic physiology, Perception physiology
- Abstract
It is estimated that nearly 90% of children on the autism spectrum exhibit sensory atypicalities. What aspects of sensory processing are affected in autism? Although sensory processing can be studied along multiple dimensions, two of the most basic ones involve examining instantaneous sensory responses and how the responses change over time. These correspond to the dimensions of 'sensitivity' and 'habituation'. Results thus far have indicated that autistic individuals do not differ systematically from controls in sensory acuity/sensitivity. However, data from studies of habituation have been equivocal. We have studied habituation in autism using two measures: galvanic skin response (GSR) and magneto-encephalography (MEG). We report data from two independent studies. The first study, was conducted with 13 autistic and 13 age-matched neurotypical young adults and used GSR to assess response to an extended metronomic sequence. The second study involved 24 participants (12 with an ASD diagnosis), different from those in study 1, spanning the pre-adolescent to young adult age range, and used MEG. Both studies reveal consistent patterns of reduced habituation in autistic participants. These results suggest that autism, through mechanisms that are yet to be elucidated, compromises a fundamental aspect of sensory processing, at least in the auditory domain. We discuss the implications for understanding sensory hypersensitivities, a hallmark phenotypic feature of autism, recently proposed theoretical accounts, and potential relevance for early detection of risk for autism.
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- 2021
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7. Characterizing autonomic response to arousing visual-auditory multi-modal task in Autism Spectrum Disorder (ASD).
- Author
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Cavinato L, Cardinaux A, Jain K, Jamal W, Kjelgaard M, Sinha P, and Barbieri R
- Subjects
- Electrocardiography, Humans, Arousal, Autism Spectrum Disorder physiopathology, Autonomic Nervous System, Heart Rate
- Abstract
Sensory abnormalities are widespread in Autism Spectrum Disorder (ASD). However, their definition is still quite subjective and vague. Here we propose a novel approach for characterization of Autonomic Nervous System responses to sensory stimulation based on electrocardiogram (ECG) assessment. In particular, we develop a preliminary study where autonomic responses of both autistic (ASD = 5) and neurotypical (NT = 5) participants have been evaluated in terms of changes in responsiveness to repeated stimuli. Autonomic control has been estimated via high-frequency heart rate variability (HF-HRV) and low-frequency HRV (LF-HRV). Results show significant differences among groups for the HRV measures (p value = 0.0158), supported by expected changes of HF (p value = 0.0079) and LF (p value = 0.0079) trends over stimulations. We thus conclude that an overall decrease in autonomic arousal can give important insights for devising new habituation metrics in NT and ASD individuals.
- Published
- 2019
- Full Text
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8. Shared neuroanatomical substrates of impaired phonological working memory across reading disability and autism.
- Author
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Lu C, Qi Z, Harris A, Weil LW, Han M, Halverson K, Perrachione TK, Kjelgaard M, Wexler K, Tager-Flusberg H, and Gabrieli JD
- Abstract
Background: Individuals with reading disability or individuals with autism spectrum disorder (ASD) are characterized, respectively, by their difficulties in reading or social communication, but both groups often have impaired phonological working memory (PWM). It is not known whether the impaired PWM reflects distinct or shared neuroanatomical abnormalities in these two diagnostic groups., Methods: White-matter structural connectivity via diffusion weighted imaging was examined in sixty-four children, ages 5-17 years, with reading disability, ASD, or typical development (TD), who were matched in age, gender, intelligence, and diffusion data quality., Results: Children with reading disability and children with ASD exhibited reduced PWM compared to children with TD. The two diagnostic groups showed altered white-matter microstructure in the temporo-parietal portion of the left arcuate fasciculus (AF) and in the temporo-occipital portion of the right inferior longitudinal fasciculus (ILF), as indexed by reduced fractional anisotropy and increased radial diffusivity. Moreover, the structural integrity of the right ILF was positively correlated with PWM ability in the two diagnostic groups, but not in the TD group., Conclusions: These findings suggest that impaired PWM is transdiagnostically associated with shared neuroanatomical abnormalities in ASD and reading disability. Microstructural characteristics in left AF and right ILF may play important roles in the development of PWM. The right ILF may support a compensatory mechanism for children with impaired PWM.
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- 2016
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9. Auditory temporal structure processing in dyslexia: processing of prosodic phrase boundaries is not impaired in children with dyslexia.
- Author
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Geiser E, Kjelgaard M, Christodoulou JA, Cyr A, and Gabrieli JD
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- Auditory Perception physiology, Case-Control Studies, Child, Female, Humans, Male, Dyslexia physiopathology, Speech Perception physiology, Time Perception physiology
- Abstract
Reading disability in children with dyslexia has been proposed to reflect impairment in auditory timing perception. We investigated one aspect of timing perception--temporal grouping--as present in prosodic phrase boundaries of natural speech, in age-matched groups of children, ages 6-8 years, with and without dyslexia. Prosodic phrase boundaries are characterized by temporal grouping of functionally related speech elements and can facilitate syntactic processing of speech. For example, temporary syntactic ambiguities, such as early-closure structures, are processed faster when prosodic phrase boundaries are present. We examined children's prosodic facilitation by measuring their efficiency of sentence processing for temporary syntactic ambiguities spoken with (facilitating) versus without (neutral) prosodic phrase boundaries. Both groups of children benefited similarly from prosodic facilitation, displaying faster reaction times in facilitating compared to neutral prosody. These findings indicate that the use of prosodic phrase boundaries for speech processing is not impaired in children with dyslexia.
- Published
- 2014
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10. The influence of prosodic structure on the interpretation of temporary syntactic ambiguity by young and elderly listeners.
- Author
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Kjelgaard MM, Titone DA, and Wingfield A
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- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Language Tests, Linguistics, Male, Middle Aged, Time Factors, Aging physiology, Language
- Abstract
The contribution of prosody to the interpretation of temporary syntactic ambiguity was examined for young and elderly listeners using a sentence-completion task. Temporary syntactic ambiguity refers to cases where it may be temporarily unclear whether a syntactic clause boundary has or has not been reached based on what has been heard in the sentence to that point. Results suggest that both young and elderly adults use a computationally less demanding late-closure parsing strategy whenever possible, but that sentence prosody can override this tendency when an alternative closure position is clearly signaled. Although subtle differences appeared in regard to sentence completion strategies and latencies to completion, results suggest that efficient resolution of syntactic boundary uncertainty and effective use of sentence prosody are two features of language comprehension that remain well-preserved in normal aging.
- Published
- 1999
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11. The influence of prosodic structure on the resolution of temporary syntactic closure ambiguities.
- Author
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Speer SR, Kjelgaard MM, and Dobroth KM
- Subjects
- Cognition, Humans, Phonetics, Speech Acoustics, Time Factors, Language, Speech Perception
- Abstract
This paper investigates the influence of prosodic structure on the process of sentence comprehension, with a specific focus on the relative contributions of syntactic and prosodic information to the resolution of temporary syntactic closure ambiguities. We argue that prosodic structure provides an initial memory representation for spoken sentences, and that information from this prosodic representation is available to inform syntactic parsing decisions. This view makes three predictions for the processing of temporary syntactic ambiguity: 1. When prosodic and syntactic boundaries coincide, syntactic processing should be facilitated. 2. When prosodic boundaries are placed at misleading points in syntactic structure, syntactic processing should show interference effects. 3. The processing difficulties that have been reliably demonstrated in reading experiments for syntactically complex sentences should disappear when those sentences are presented with a felicitous prosodic structure in listening experiments. These predictions were confirmed by series of experiments measuring end-of-sentence comprehension time and cross-modal naming time for sentences with temporary syntactic closure ambiguities. Sentences with coinciding or conflicting prosodic and syntactic boundaries were compared to a prosodic baseline condition.
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- 1996
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12. Dissociations among structural-perceptual, lexical-semantic, and event-fact memory systems in Alzheimer, amnesic, and normal subjects.
- Author
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Gabrieli JD, Keane MM, Stanger BZ, Kjelgaard MM, Corkin S, and Growdon JH
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- Adult, Aged, Alzheimer Disease diagnosis, Alzheimer Disease psychology, Amnesia diagnosis, Amnesia psychology, Brain Damage, Chronic diagnosis, Brain Damage, Chronic psychology, Brain Mapping, Cerebral Cortex physiopathology, Female, Humans, Limbic System physiopathology, Male, Middle Aged, Neuropsychological Tests, Paired-Associate Learning physiology, Pattern Recognition, Visual physiology, Reference Values, Retention, Psychology physiology, Alzheimer Disease physiopathology, Amnesia physiopathology, Attention physiology, Brain Damage, Chronic physiopathology, Mental Recall physiology, Verbal Learning physiology
- Abstract
Patients with Alzheimer's disease (AD), patients with global amnesia (AMN), and normal control (NC) subjects received tests of recall and recognition, word-completion priming, and incomplete-picture priming. The AD and AMN patients had impaired recall and recognition. The AD patients, but not the AMN patients, had impaired word-completion priming. In contrast, the AD patients had intact incomplete-picture priming, a form of priming shown to be perceptual in normal subjects. These results provide neuropsychological evidence for a dissociation between two components of repetition priming, perceptual priming as measured with identification tasks and nonperceptual priming as measured with generation tasks. Preserved perceptual priming in AD may be mediated by the occipital regions that are relatively spared in AD; compromised nonperceptual priming may be mediated by temporal regions that show dense neuropathological changes early in AD.
- Published
- 1994
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