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A rhizosphere isolate Streptomyces sp. CAH29 was found to possess potent antibacterial and antifungal activity against a variety of test organisms. Based on 16S ribosomal ribonucleic acid sequence homology studies, this strain was found to be similar to Streptomyces stramineus (gene sequence similarity 99 %). The major bioactive metabolite produced by Streptomyces sp. CAH29 isolate was extracted, purified andidentified by nuclear magnetic resonance as tetrangomycin. This known anthraquinone-exhibited antimicrobial activity against Staphylococcus aureus, Streptococcus pyogenes, methicillin resistant Staphylococcus aureus and Candida albicans with inhibition zones of 14, 10, 12 and 8 mm, respectively. Docking results demonstrate that tetrangomycin has a similar mode of action and a comparable docking score to bind to the dehydrosqualene synthase (CrtM) enzyme of methicillin resistant Staphylococcus aureus compared to the current inhibitor. Hence, this suggests that tetrangomycin has a potential to be used as an anti-methicillin resistant Staphylococcus aureus agent. Tetrangomycin also showed moderate free radical scavenging activity with 1,1-diphenyl-2-picryl-hydrazil. Tetrangomycin apparently decreased all of the studied cytokine (pro-inflammatory: interleukin 1B, interleukin 2, tumor necrosis factor and interleukin L6 and anti-inflammatory: interleukin 10) expression levels at IC50 concentrations in A459 (adenocarcinomic human alveolar basal epithelial) and LNCAP (human prostate adenocarcinoma) cell lines. In addition, it reduced Caspase 8 and 3 mRNA levels in LNCAP and A549 cells. This study describes for the first time novel in vitro immunosuppressive function of tetrangomycin by reducing the transcription of cytokine genes.

Стаття присвяченa дослідженню комп’ютерних абревіатур і скорочень англійської мови. У статті також подано коротку характеристику історії появи та використання скорочених одиниць, з’ясовано їх базові дифе¬ренціальні параметри, проаналізовано спільні та відмінні риси cкорочень, абревіатур, акронімів, визначено їх роль у науково-технічних текстах англійської мови. Найбільш поширеними типами абревіатур, що засто¬со¬вують у текстах комп’ютерної тематики, є ініціальні абревіатури чи буквені скорочення, контамінанти. Такі одиниці – засоби скорочення багатокомпонентних комп’ютерних термінів англійської мови. Абревіатури вка¬заної сфери розподіляють також на нетрадиційні (нестандартні), фразові та комбіновані. Нетрадиційними (нестандартними) є літерно-цифрові абревіатури, які широко використовують у віртуальному комунікативному просторі для оптимізації обміну та передачі інформації. Досягненню подібної мети сприяє також використання фразових абревіатур, що є засобами скорочення розмовних фраз і словосполучень. Комбіновані абревіатури поєднують у собі риси фразових і нетрадиційних абревіатур. Подальші дослідження вбачаємо в детальному аналізі структурно-семантичних характеристик абревіатур вищевказаної сфери англійської мови. The article is devoted to the investigation of computer abbreviations and shortenings of the English language. The brief characteristic of the history of emergence and usage of shortened units is also given in the article. Common and distinctive features of shortenings, abbreviations and acronyms as well as their role in the scientific and technical texts of the English language are revealed in it. The most common types of abbreviations used in the texts on the computer issues are initial abbreviations or alphabetic shortenings and contaminations. Such units are considered to be the means of shortening of the compound computer terms in the English language. Abbreviations of the mentioned sphere are also subdivided into non-traditional (non-standard), phrasal and combined. Non-traditional (non-standard) are alpha-numeric abbreviations widely used in the sphere of virtual communication swith the aim of optimization of information exchange. The usage of phrasal abbreviations that are means of shortening of colloquial phrases and word combinations, also contributes to this aim achievement. Combined abbreviations share features of phrasal and nontraditional abbreviations. Further research lies in the detailed analysis of structural and semantic features of the abbreviations in the abovementioned sphere of the English language.

The development of short- and medium-term mine production schedules in isolation from each other has meant that only a local optimum can be achieved when each scheduling phase is carried out. The globally optimal solution, however, can be achieved when integrating scheduling phases and accounting for the interaction between short-term and medium-term activities simultaneously. This paper addresses the task of integrating short- and medium-term production plans by combining the short-term objective of minimizing deviation from targeted mill feed grade with the medium-term objective of maximizing net present value (NPV) into a single mathematical optimization model. A conceptual sublevel stoping operation comprising 30 stopes is used for trialling segregated and integrated scheduling approaches. Segregated medium- and short-term scheduling using separate models achieved an NPV of $42 654 456. The final scheduling approach involved integrating the two scheduling horizons using the newly-developed globally optimal integrated production scheduling model to achieve an NPV of $42 823 657 with smoother mill feed grade. The larger the stope data set, the larger the difference between the two scheduling approaches is likely to be. At the very least, an integrated approach ensures feasibility across the two scheduling horizons, which cannot always be assumed when using a segregated approach.

The primary purpose of this study was to determine differences of patients' satisfaction after HACCP/ISO 22000 implementation in hospital food service. The subjects were 466 patients consisting of 191 males, 275 females from different clinics in one of university hospital. The questionnaire of food and food service satisfaction of patients were filled by intern dietician.Before HACCP/ISO 22000 implementation overall score of patients' satisfaction was 74.7, after HACCP/ISO 22000 implementation it was increase to 81.3 p=0.000. As like as this result approximately all of individual scores (organoleptic, menu and service) were increase after HACCP/ISO 22000 implementation p

A combination of self and peer assessment is a powerful and rich teaching and learning management tool that can be used to monitor and evaluate group performance in project work. An on-line system (SPARKPLUS â Self and Peer Assessment Resource Kit) has been developed to simplify this process for the academic. This system generates factors for both the peer assessment weighting to be applied for individual contribution and the studentâs perception of their contribution compared to their peers by using key assessment criteria and a rigorous algorithm that is applied to the student evaluations of themselves and their peers. This paper describes and evaluates the introduction of SPARKPLUS to assess the performance of Mining Engineering Undergraduates in Year 3 at The University of Queensland in the first semester of 2008 in two of their core undergraduate courses that required group project work to be completed for assessment. The results obtained from this initial trial show the potential for improving student behaviour in group work through a structured approach to monitoring and feedback of their performance. It was found that male students with GPAs ⤠5 tend to overestimate their contribution to group work more frequently than their peers whereas the opposite applies for male students with GPAs > 5.