2,055 results on '"Kiyosue, A."'
Search Results
2. A phase 2 randomized, double-blind trial of ART-001, a selective PI3Kα inhibitor, for the treatment of slow-flow vascular malformations
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Michio Ozeki, Akira Tanaka, Kanako Kuniyeda, Taiki Nozaki, Akihiro Fujino, Tadashi Nomura, Naoto Uemura, Souichi Suenobu, Noriko Aramaki-Hattori, Ayato Hayashi, Aiko Kato, Hiro Kiyosue, Kotaro Imagawa, Munetomo Nagao, Fumiaki Shimizu, Junko Ochi, Saya Horiuchi, Tetsuji Ohyama, Haruhi Ando, and Hiroshi Nagabukuro
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Phase 2 study ,Vascular malformations ,PI3Kα ,Pharmacotherapy ,And drug development ,Medicine - Abstract
Abstract Background In patients with slow-flow vascular malformations (SFVMs) including venous malformations (VM), lymphatic malformations (LM) or Klippel–Trenaunay Syndrome (KTS), somatic gain-of-function mutations in genes encoding phosphatidyl inositol 3-kinase alpha (PI3Kα, gene name PIK3CA) have been identified. A phase 2 study was conducted with the patients to assess the efficacy and safety of ART-001 (serabelisib), an orally available selective PI3Kα inhibitor. Methods This is a multicenter, randomized, double-blind, proof-of-concept, phase 2 trial. Eligible participants were patients aged 2 years and older, diagnosed either with VM, LM or KTS. Participants were administered either 50 or 100 mg of ART-001 for 24 weeks. The primary endpoint was the response rate defined as the proportion of participants who achieved ≥ 20% reduction in lesion volume at week 24. Secondary endpoints include safety, pharmacokinetics, pain, and quality of life scores. Results Thirty-five patients (median age: 14 years old; VM, n = 17, KTS, n = 13 and LM, n = 5) were randomly assigned and received treatment (50 mg, n = 17 and 100 mg, n = 18). ART-001 showed a response rate: 29.4% (95% confidence interval 10.3–56.0%) at 50 mg and 33.3% (13.3–59.0%) at 100 mg. Mean lesion volume reductions at 50 mg and 100 mg were − 2.3% (95% CI − 14.3 to 9.6%) and − 12.6% (− 25.3 to 0.06%), respectively. No drug-related serious adverse events were observed. Treatment-emergent adverse events were generally mild to moderate and transient. Pharmacokinetic profiles were similar between pediatric and adolescent/adult patients except for lower Ctrough levels in pediatric patients. Conclusion ART-001 was effective and well-tolerated in patients with SFVMs. These results support the further development of ART-001 in SFVMs and other PIK3CA-related overgrowth syndromes to confirm clinical benefits and long-term safety. Trial registration: Japan Registry of Clinical Trial, jRCT2071210027. Registered May 25 2021, https://jrct.niph.go.jp/en-latest-detail/jRCT2071210027
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- 2025
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3. The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling
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Naoyuki Kondo, Yuko Mimori-Kiyosue, Keizo Tokuhiro, Giuseppe Pezzotti, and Tatsuo Kinashi
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Science - Abstract
Abstract The leukocyte integrin LFA1 is indispensable for immune responses, orchestrating lymphocyte trafficking and adhesion. While LFA1 activation induces LFA1 clustering at the cell contact surface via outside-in signaling, the regulatory mechanisms remain unclear. Here, we uncovered a previously hidden function of the autophagosome component LC3 beyond its role in autophagy by bridging two seemingly unrelated pathways: LFA1 transport and autophagosome transport. LFA1 clusters co-trafficked with LC3, facilitating LFA1 accumulation at the contact surface. LC3b knockout decreased lymphocyte adhesiveness. LFA1 activation did not induce autophagy, whereas it increased mTOR and AMPK activity. LFA1-dependent AMPK activation enhances LFA1 and LC3 clustering and adhesion. Inhibiting Mst1 kinase-mediated LC3 phosphorylation promoted LC3-mediated LFA1 recruitment to the contact surface through direct interaction with RAPL, uncovering an unprecedented integrin recruitment route. These findings uncover a function of LC3 and expand our understanding of lymphocyte regulation via LFA1.
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- 2025
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4. Endovascular Treatment of Unruptured Pancreatic Arcade Aneurysms
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Tamura, Yoshitaka, Kiyosue, Hiro, Ikeda, Osamu, Hayashi, Hidetaka, Sasaki, Goh, and Hirai, Toshinori
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- 2024
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5. Evidence for an odd-parity nematic phase above the charge density wave transition in kagome metal CsV$_3$Sb$_5$
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Asaba, T., Onishi, A., Kageyama, Y., Kiyosue, T., Ohtsuka, K., Suetsugu, S., Kohsaka, Y., Gaggl, T., Kasahara, Y., Murayama, H., Hashimoto, K., Tazai, R., Kontani, H., Ortiz, B. R., Wilson, S. D., Li, Q., Wen, H. -H., Shibauchi, T., and Matsuda, Y.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Superconductivity - Abstract
The quest for fascinating quantum states arising from the interplay between correlation, frustration, and topology is at the forefront of condensed-matter physics. Recently discovered nonmagnetic kagome metals $A$V${_3}$Sb${_5}$ ($A=$ K, Cs, Rb) with charge density wave (CDW) and superconducting instabilities may host such exotic states. Here we report that an odd electronic nematic state emerges above the CDW transition temperature ($T_{\rm CDW}=94$ K) in CsV${_3}$Sb${_5}$. High-resolution torque measurements reveal a distinct twofold in-plane magnetic anisotropy that breaks the crystal rotational symmetry below $T^*\approx130$ K. However, no relevant anomalies are detected in the elastoresistance data near $T^*$, which excludes the even-parity ferro-orbital nematicity often found in other superconductors. Moreover, in the temperature range between $T_{\rm CDW}$ and $T^*$, conical rotations of magnetic field yield a distinct first-order phase transition, indicative of time-reversal symmetry breaking. These results provide thermodynamic evidence for the emergence of an odd-parity nematic order, implying that an exotic loop-current state precedes the CDW in CsV$_3$Sb$_5$., Comment: A revised manuscript will appear in Nature Physics
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- 2023
6. A common generalization of budget games and congestion games
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Kiyosue, Fuga and Takazawa, Kenjiro
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- 2024
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7. Theoretical model of membrane protrusions driven by curved active proteins
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Ravid, Yoav, Penič, Samo, Mimori-Kiyosue, Yuko, Suetsugu, Shiro, Iglič, Aleš, and Gov, Nir S.
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Condensed Matter - Soft Condensed Matter ,Physics - Biological Physics ,Quantitative Biology - Cell Behavior - Abstract
Eukaryotic cells intrinsically change their shape, by changing the composition of their membrane and by restructuring their underlying cytoskeleton. We present here further studies and extensions of a minimal physical model, describing a closed vesicle with mobile curved membrane protein complexes. The cytoskeletal forces describe the protrusive force due to actin polymerization which is recruited to the membrane by the curved protein complexes. We characterize the phase diagrams of this model, as function of the magnitude of the active forces, nearest-neighbor protein interactions and the proteins' spontaneous curvature. It was previously shown that this model can explain the formation of lamellipodia-like flat protrusions, and here we explore the regimes where the model can also give rise to filopodia-like tubular protrusions. We extend the simulation with curved components of both convex and concave species, where we find the formation of complex ruffled clusters, as well as internalized invaginations that resemble the process of endocytosis and macropinocytosis. We alter the force model representing the cytoskeleton to simulate the effects of bundled instead of branched structure, resulting in shapes which resemble filopodia., Comment: 28 pages, 15 figure; Supplementary information is available in https://weizmann.box.com/s/5z6aexxk1lmne0b29sf25o451unnj85x (PDF links might be broken). Submitted to Frontiers in Molecular Biosciences and cellular biochemistry special issue "Exploring the Molecular Interplay between the Plasma Membrane and Cytoskeleton during Signal Transduction"
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- 2023
8. Potential of High-Spatiotemporal Resolution Live Cell Imaging for Drug Discovery and Development
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Mimori-Kiyosue, Yuko, Koizumi, Tomonobu, Washio, Takashi, Satoh, Hiroko, editor, Funatsu, Kimito, editor, and Yamamoto, Hiroshi, editor
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- 2024
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9. Effect of cardiac rehabilitation on progression to long-term care: A clinical and economic longitudinal study in Japan
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Takura, Tomoyuki, Kiyosue, Arihiro, Koyama, Teruyuki, Takei, Mitsuo, and Honda, Asao
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- 2025
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10. Changes in systolic blood pressure during hospitalisation and bleeding events after percutaneous coronary intervention
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Kazuomi Kario, Ryozo Nagai, Kenichi Tsujita, Yoshihiro Miyamoto, Yasushi Imai, Tomoyuki Kabutoya, Hideo Fujita, Kotaro Nochioka, Tetsuya Matoba, Arihiro Kiyosue, Taishi Nakamura, Masanobu Ishii, Yasuhiro Otsuka, So Ikebe, Takahide Kohro, Yusuke Oba, Yoshiko Mizuno, Masaharu Nakayama, Takamasa Iwai, Hisahiko Sato, and Naoyuki Akashi
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Hypertension is a risk factor for bleeding events and is included in the HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile INR, Elderly, Drugs/Alcohol concomitantly)score. However, the effects of blood pressure (BP) and changes in BP on bleeding events in patients undergoing percutaneous coronary intervention (PCI) remain poorly understood. This study is aimed to investigate the relationship between systolic BP (SBP) changes during hospitalisation and bleeding events in patients undergoing PCI.Methods From the Clinical Deep Data Accumulation System database, a multicentre database encompassing seven tertiary medical hospitals in Japan that includes data for patient characteristics, medications, laboratory tests, physiological tests, cardiac catheterisation and PCI treatment, data for 6351 patients undergoing PCI between April 2013 and March 2019 were obtained. The study population was categorised into three groups based on the changes in SBP during hospitalisation: (1) elevated BP (≥20 mm Hg), (2) no change (≥−20 to
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- 2024
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11. Relationship between the number of drugs used during percutaneous coronary intervention and adverse events in patients with chronic coronary syndrome: Analysis of CLIDAS database
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Yasuhiro Hitomi, Yasushi Imai, Masanari Kuwabara, Yusuke Oba, Tomoyuki Kabutoya, Kazuomi Kario, Hisaki Makimoto, Takahide Kohro, Eiichi Shiraki, Naoyuki Akashi, Hideo Fujita, Tetsuya Matoba, Yoshihiro Miyamoto, Arihiro Kiyosue, Kenichi Tsujita, Masaharu Nakayama, and Ryozo Nagai
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Chronic coronary syndrome ,CCS ,Polypharmacy ,Number of prescriptions ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Polypharmacy is associated with an increased risk of adverse events due to the higher number of drugs used. This is particularly notable in patients with chronic coronary syndrome (CCS), who are known to use a large number of drugs. Therefore, we investigated polypharmacy in patients with CCS, using CLIDAS, a multicenter database of patients who underwent percutaneous coronary intervention. Method and results: Between 2017 and 2020, 1411 CCS patients (71.5 ± 10.5 years old; 77.3 % male) were enrolled. The relationship between cardiovascular events occurring during the median follow-up of 514 days and the number of drugs at the time of PCI was investigated. The median number of drugs prescribed was nine. Major adverse cardiovascular events (MACE), defined as cardiovascular death, myocardial infarction, stroke, heart failure, transient ischemic attack, or unstable angina, occurred in 123 patients, and all-cause mortality occurred in 68 patients. For each additional drug, the adjusted hazard ratios for MACE and all-cause mortality increased by 2.069 (p = 0.003) and 1.102 (p = 0.010). The adjusted hazard ratios for MACE and all-cause mortality were significantly higher in the group using nine or more drugs compared to the group using eight or fewer drugs (1.646 and 2.253, both p
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- 2024
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12. Implication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature
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Shunsuke Chuma, Kazuyuki Kiyosue, Taishu Akiyama, Masaki Kinoshita, Yukiho Shimazaki, Seiichi Uchiyama, Shingo Sotoma, Kohki Okabe, and Yoshie Harada
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Science - Abstract
Abstract Neuronal differentiation—the development of neurons from neural stem cells—involves neurite outgrowth and is a key process during the development and regeneration of neural functions. In addition to various chemical signaling mechanisms, it has been suggested that thermal stimuli induce neuronal differentiation. However, the function of physiological subcellular thermogenesis during neuronal differentiation remains unknown. Here we create methods to manipulate and observe local intracellular temperature, and investigate the effects of noninvasive temperature changes on neuronal differentiation using neuron-like PC12 cells. Using quantitative heating with an infrared laser, we find an increase in local temperature (especially in the nucleus) facilitates neurite outgrowth. Intracellular thermometry reveals that neuronal differentiation is accompanied by intracellular thermogenesis associated with transcription and translation. Suppression of intracellular temperature increase during neuronal differentiation inhibits neurite outgrowth. Furthermore, spontaneous intracellular temperature elevation is involved in neurite outgrowth of primary mouse cortical neurons. These results offer a model for understanding neuronal differentiation induced by intracellular thermal signaling.
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- 2024
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13. Detailed Anatomy of Bridging Veins Around the Foramen Magnum: a Multicenter Study Using Three-dimensional Angiography
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Hiramatsu, Masafumi, Ozaki, Tomohiko, Tanoue, Shuichi, Mizutani, Katsuhiro, Nakamura, Hajime, Tokuyama, Kohei, Sakata, Hiroyuki, Matsumaru, Yuji, Nakahara, Ichiro, Niimi, Yasunari, Fujinaka, Toshiyuki, and Kiyosue, Hiro
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- 2024
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14. Evidence for an odd-parity nematic phase above the charge-density-wave transition in a kagome metal
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Asaba, T., Onishi, A., Kageyama, Y., Kiyosue, T., Ohtsuka, K., Suetsugu, S., Kohsaka, Y., Gaggl, T., Kasahara, Y., Murayama, H., Hashimoto, K., Tazai, R., Kontani, H., Ortiz, B. R., Wilson, S. D., Li, Q., Wen, H. -H., Shibauchi, T., and Matsuda, Y.
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- 2024
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15. Abstract 4135327: Long-term Bleeding Events after Percutaneous Coronary Intervention in Patients with Malignancy with and without Anticoagulant Therapy
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Otsuka, Yasuhiro, Ishii, Masanobu, Nakamura, Taishi, Tsujita, Kenichi, Fujita, Hideo, Matoba, Tetsuya, Kohro, Takahide, Kabutoya, Tomoyuki, Kario, Kazuomi, Kiyosue, Arihiro, Mizuno, Yoshiko, Nakayama, Masaharu, Miyamoto, Yoshihiro, Sato, Hisahiko, and Nagai, Ryozo
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- 2024
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16. Abstract 4124931: Usefulness of the AHEAD Score for Prediction of All-cause Death in Patients With Acute and Chronic Coronary Syndromes
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Tamaki, Shunsuke, Higaki, Akinori, Kawakami, Hiroshi, Nishimura, Kazuhisa, Inoue, Katsuji, Ikeda, Shuntaro, Yamaguchi, Osamu, Akashi, Naoyuki, Matoba, Tetsuya, Kohro, Takahide, Kabutoya, Tomoyuki, Kario, Kazuomi, Kiyosue, Arihiro, Nakayama, Masaharu, Miyamoto, Yoshihiro, Tsujita, Kenichi, Fujita, Hideo, and Nagai, Ryozo
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- 2024
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17. Corrigendum to 'Impact of heart failure severity and major bleeding events after percutaneous coronary intervention on subsequent major adverse cardiac events' [Int. J. Cardiol. Cardiovasc. Risk and Prev. 2023 Jun 25:18:200193]
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So Ikebe, Masanobu Ishii, Yasuhiro Otsuka, Taishi Nakamura, Kenichi Tsujita, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario, Arihiro Kiyosue, Yoshiko Mizuno, Kotaro Nochioka, Masaharu Nakayama, Takamasa Iwai, Yoshihiro Miyamoto, Hisahiko Sato, Naoyuki Akashi, Hideo Fujita, and Ryozo Nagai
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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18. Burden of respiratory syncytial virus infections in older adults with acute respiratory infection in Japan: An epidemiological study among outpatients
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Ohbayashi, Hiroyuki, Sakurai, Takayuki, Himeji, Daisuke, Fukushima, Yasushi, Takahashi, Hiroshi, Kiyosue, Arihiro, Sabater Cabrera, Eliazar, Matsuki, Taizo, Molnar, Daniel, Preckler Moreno, Victor, Damaso, Silvia, Pirçon, Jean-Yves, and Moitinho de Almeida, Maria
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- 2024
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19. Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial
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Abe, Mitsunori, Abhaichand, Rajpal K, Abhayaratna, Walter P, Abhyankar, Atul, Abidin, Imran B Zainal, Abou Assi, Hiba, Accini Mendoza, Jose L, Adas, Mine, Agaiby, John M, Agarwal, Devendra K, Agha, Maher, Ahmed, Azazuddin, Ahtiainen, Petteri, Aigner, Elmar, Ajay, Naik, Ali, Norsiah, Al-Karadsheh, Amer, Allison, Roy, Allison, Dale C, Alpenidze, Diana, Altuntas, Yuksel, Al-Zoebi, Ayham, Ambuj, Roy, Amerena, John, Anderson, Robert J, Ando, Toshiaki, Andrews, Robert, Antonova, Elizaveta, Appel, Karl-Friedrich, Arantes, Flávia B, Araz, Mustafa, Arbel, Yaron, Arenas León, José L, Argyrakopoulou, Georgia, Ariani, Mehrdad, Arias Mendoza, Maria A, Arif, Ahmed A, Arneja, Jaspal, Aroda, Vanita R, Aronne, Louis J, Arstall, Margaret, Asamoah, Njaimeh, Asanin, Milika, Audish, Hanid, Avram, Rodica, Badat, Aysha, Badiu, Corin V, Bakdash, Wa'el, Bakiner, Okan S, Bandezi, Vuyokazi N, Bang, Liew H, Bansal, Sandeep, Baranyai, Marietta, Barbarash, Olga, Barber, Mark, Barnum, Otis, Barone Rochette, Gilles, Bashkin, Amir, Baum, Seth, Bays, Harold E, Bazzoni Ruiz, Alberto E, Beckowski, Maciej, Beerachee, Yaswin, Bellary, Srikanth, Belousova, Lidia, Berk, Martin, Bernstein, Marc, Berra, Cesare, Beshay, Isaac, Bhagwat, Ajit, Bhan, Arti, Biggs, William C, Billings, Liana, Bitar, Fahed, Block, Bradley, Bo, Simona, Bogdanski, Pawel, Bolshakova, Olga O, Boshchenko, Alla A, Bosworth, Hayden, Botero Lopez, Rodrigo, Bôttcher, Morten, Bourgeois, Ronald, Brautigam, Donald, Breton, Cristian F, Broadley, Andrew, Brockmyre, Andrew P, Brodie, Steven K, Bucci, Marco, Budincevic, Hrvoje, Budoff, Matthew J, Buffman, Barry, Buljubasic, Nediljka, Buranapin, Supawan, Burgess, Lesley, Burguera, Bartolomé, Buriakovska, Olena, Buscemi, Silvio, Busch, Robert, Buse, John B, Buynak, Robert, Byrne, Maria, Caceaune, Elena, Cadena Bonfanti, Alberto J, Calinescu, Cornell V, Call, Robert S, Canecki Varzic, Silvija, Cannon, Kevin, Capehorn, Matt, Cariou, Bertrand, Carr, Jeffrey, Carrillo-Jimenez, Rodolfo, Casas, Marcelo, Castro, Almudena, Celik, Ahmet, Cercato, Cintia, Cermak, Ondrej, Cha, James Y, Chacon, Carolina, Chaicha-Brom, Tira, Chandra, Sandeep, Chettibi, Mohamed, Chevts, Julia, Christopher, Johann, Chrustowski, Witold, Cif, Adriana, Clark, Rebecca, Clark, Wayne, Clifford, Piers, Coetzee, Kathleen, Cogni, Giulia, Colao, Anna Maria, Colquhoun, David M, Concha, Mauricio, Condit, Jonathan, Constance, Christian, Constantin, Ciprian, Constantinescu, Silviana, Corbett, Clive, Cornett, George M, Correia, Marcelo, Cortinovis, Fiorenzo, Cosma, Dana, Creely, Steven, Cross, David, Curtis, Brian, Czochra, Wojciech, Daboul, Nizar Y, Dagdelen, Selcuk, D'agostino, Ronald, Dang, Cuong, Datta, Sudip, Davuluri, Ashwini K, Dawood, Saleem Y, De Jong, Douwe M, De La Cuesta, Carmen, De Los Rios Ibarra, Manuel O, De Pablo, Carmen, De Pauw, Michel, Dela Llana, Alexander, Delibasic, Maja, Delic-Brkljacic, Diana, Demicheli, Thibaud, Denger, Ralf J, Desai, Devang, Desai, Piyush, Desouza, Cyrus V, Dicker, Dror, Djenic, Nemanja, Dobson, Simon, Doi, Masayuki, Doran, Jesse A, Dorman, Reinhart, Dotta, Francesco, Dukes, Carl E, Duronto, Ernesto, Durst, Ronen, Dvoryashina, Irina V, Ebrahim, Iftikhar O, Eggebrecht, Holger, Egstrup, Kenneth, Ekinci, Elif I, Eliasson, Björn, Eliasson, Ken, Enache, Georgiana, Enculescu, Dan, English, Patrick, Ermakova, Polina, Ershova, Olga, Ezaki, Hirotaka, Ezhov, Marat, Farias, Eduardo, Farias, Javier M, Farsky, Pedro S, Ferreira, Daniel, Filteau, Pierre, Finneran, Matthew P, Folkens, Eric M, Fonseca, Alberto G, Fonseca, Luisa, Fordan, Steven, Fourie, Nyda, França, Sara, Franco, Denise R, Franek, Edward, Friedman, Keith, Frittitta, Lucia, Froer, Michael, Fuckar, Krunoslav, Fujii, Kenshi, Fujita, Ryoko, Fukushima, Yasushi, Fulat, Mohamed, Fulwani, Mahesh, Gajos, Grzegorz, Galyavich, Albert, Gambill, Michael L, Gandotra, Dheeraj, Winston, Gandy, Jr., Garcia Hernandez, Pedro A, García Reza, Raymundo, Garg, Naveen, Garg, Sandeep, Garvey, William T, Garza, Juan C, Gatta-Cherifi, Blandine, Gelev, Valeri, Geller, Steven A, Geohas, Jeffrey G, Georgiev, Borislav, Ghazi, Adline, Gilbert, Matthew P, Gilinskaya, Olga, Gislason, Gunnar, Gogas Yavuz, Dilek, González Albarrán, Olga, Gordeev, Ivan G, Gorton, Sidney C, Goudev, Assen, Gretland Valderhaug, Tone, Groenemeijer, Bjorn, Gul, Ibrahim, Gullestad, Lars, Gurieva, Irina, Guseva, Galina N, Hagenow, Andreas, Haluzik, Martin, Halvorsen, Sigrun, Hammoudi, Naima, Hanaoka, Keiichi, Hancu, Nicolae, Hanusch, Ursula, Harris, Kathleen, Harris, Barry, Hartleib, Michael, Hartman, Aaron N, Hata, Yoshiki, Heimer, Brian, Herman, Lee, Herzog, William, Hewitt, Eric, Heymer, Peter, Hiremath, Shirish, Hjelmesaeth, Joeran, Høgalmen, Rasmus Geir, Høivik, Hans Olav, Holmer, Helene, Horoshko, Olha, Houser, Patricia M, Hove, Jens D, Hsieh, I-Chang, Hulot, Jean-Sébastien, Hussein, Zanariah, Ilashchuk, Tetiana, Ilveskoski, Erkki, Ipatko, Irina, Iranmanesh, Ali, Isawa, Tsuyoshi, Issa, Moises, Iteld, Bruce, Iwasawa, Takamasa, Jabbar, Danish, Jackson, Richard A, Jackson-Voyzey, Ewart, Jacob, Stephan, Jaffrani, Naseem A, Jardula, Michael F, Jastreboff, Ania, Jensen, Svend E, Jerkins, Terri, Jimenez-Ramos, Silvia A, Jitendra Pal Singh, Sawhney, Johnson, Wallace, Joyce, John M, Jozefowska, Malgorzata, Jugnundan, Prakash, Jungmair, Wolfgang, Jurowiecki, Jaroslaw, Kadokami, Toshiaki, Kahali, Dhiman, Kahrmann, Gerd, Kaiser, Sergio E, Kalmucki, Piotr, Kanadasi, Mehmet, Kandath, David, Kania, Grzegorz, Kannan, J, Kapp, Cornelia, Karczmarczyk, Agnieszka, Kartalis, Athanasios, Kaser, Susanne, Kasim, Sazzli Shahlan, Kastelic, Richard, Kato, Toshiaki, Katova, Tzvetana, Kaul, Upendra, Kautzky-Willer, Alexandra, Kawanishi, Masahiro, Kayikcioglu, Meral, Kazakova, Elena E, Keeling, Philip, Kempe, Hans-Peter, Kereiakes, Dean J, Kerneis, Mathieu, Keski-Opas, Tiina, Khadra, Suhail, Khaisheva, Larisa, Kharakhulakh, Marina, Khlevchuk, Tatiana, Khoo, Jeffrey, Kiatchoosakun, Songsak, Kinoshita, Noriyuki, Kinoshita, Masaharu, Kitamura, Ryoji, Kiyosue, Arihiro, Klavina, Irina, Klein, Eric J, Klimsa, Zdenek, Klonoff, David, Klug, Eric, Kobalava, Zhanna, Kodera, Satoshi, Koga, Tokushi, Kokkinos, Alexander, Koleckar, Pavel, Könyves, László, Koren, Michael J, Kormann, Adrian P, Kostner, Karam, Kreutzmann, Kristin, Krishinan, Saravanan, Krishnasamy, Sathya S, Krivosheeva, Inga, Kruljac, Ivan, Kubicki, Ted, Kuchar, Ladislav, Kujawiak, Monika, Kunishige, Hideyuki, Kurtinecz, Melinda, Kurtz Lisboa, Hugo R, Kushnir, Mykola, Kyyak, Yulian, Lace, Arija, Lakka, Timo, Lalic, Nebojsa, Lalic, Katarina, Lambadiari, Vaia, Lanaras, Leonidas, Lang, Chim, Langlois, Marie-France, Lash, Joseph, Latkovskis, Gustavs, Lau, David, Lazcano Soto, José Roberto, Le Roux, Carel, Ledesma, Gilbert N, Lee, Li Yuan, Lee, Thung-Lip, Lee, Kelvin, Lehrke, Michael, Leite, Silmara O, Leksycka, Agata, Lenzmeier, Thomas, Leonetti, Frida, Leonidova, Viktoriia, Lepor, Norman, Leung, Melissa, Levchenko, Olena, Levins, Peter, Levy, Louis J, Lewis, Matthew, Liberopoulos, Evangelos, Liberty, Idit, Lindholm, Carl-Johan, Lingvay, Ildiko, Linhart, Ales, Liu, Ming-En, Liu, Jenny, Lofton, Holly, Logemann, Timothy, Lombaard, Johannes J, Lombard, Landman, Lorraine, Richard, Lovell, Charles F, Ludvik, Bernhard, Lukaszewicz, Monika, Lupkovics, Géza, Lupovitch, Steven, Lupu, Sirona, Lynch, Mary, Lysak, Zoreslava, Lysenko, Tatyana A, Maeda, Hajime, Maeda, Itaru, Mæng, Michael, Mahajan, Ajay U, Maher, Vincent, Maia, Lilia N, Makotoko, Ellen M, Malavazos, Alexis, Malecha, Jan, Malicherova, Emilia, Manita, Mamoru, Mannucci, Edoardo, Mareev, Viacheslav, Marin, Liliana, Markova, Tatiana, Marso, Steven P, Martens, F.M.A.C., Martinez, Cuper, Martinez Cano, Carlos A, Martins, Cristina, Masmiquel Comas, Luis, Matsumoto, Takashi, Mcdonald, Kenneth, Mcgowan, Barbara, Mcgrew, Frank, Mclean, Barry K, Mcpherson, David D, Merino Torres, Juan Francisco, Meyers, Peter, Meyhöfer, Sebastian, Mezquita Raya, Pedro, Milanova, Maria, Milicic, Davor, Miller, Gary, Mills, Richard E, 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- 2024
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20. Change in pulse pressure and cardiovascular outcomes after percutaneous coronary intervention: The CLIDAS study
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Nochioka, Kotaro, Nakayama, Masaharu, Akashi, Naoyuki, Matoba, Tetsuya, Kohro, Takahide, Oba, Yusuke, Kabutoya, Tomoyuki, Imai, Yasushi, Kario, Kazuomi, Kiyosue, Arihiro, Mizuno, Yoshiko, Iwai, Takamasa, Miyamoto, Yoshihiro, Ishii, Masanobu, Nakamura, Taishi, Tsujita, Kenichi, Sato, Hisahiko, Fujita, Hideo, and Nagai, Ryozo
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- 2024
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21. Transarterial Embolization of Renal Arteriovenous Malformations: Treatment Outcomes According to Angiographic Classification
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Hayashi, Hidetaka, Kiyosue, Hiro, Tamura, Yoshitaka, Ueda, Hiroyuki, Yonemura, Mari, Sasaki, Goh, Hokamura, Masamichi, Ishiuchi, Soichiro, Kanaya, Hiroshi, Uetani, Hiroyuki, Oda, Seitaro, Kawanaka, Koichi, and Hirai, Toshinori
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- 2024
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22. Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial
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23. Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial
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Judge, PK, Staplin, N, Mayne, KJ, Wanner, C, Green, JB, Hauske, SJ, Emberson, JR, Preiss, D, Ng, SYA, Roddick, AJ, Sammons, E, Zhu, D, Hill, M, Stevens, W, Wallendszus, K, Brenner, S, Cheung, AK, Liu, ZH, Li, J, Hooi, LS, Liu, WJ, Kadowaki, T, Nangaku, M, Levin, A, Cherney, D, Maggioni, AP, Pontremoli, R, Deo, R, Goto, S, Rossello, X, Tuttle, KR, Steubl, D, Massey, D, Landray, MJ, Baigent, C, Haynes, R, Herrington, WG, Abat, S, Abd Rahman, R, Abdul Cader, R, Abdul Hafidz, MI, Abdul Wahab, MZ, Abdullah, NK, Abdul-Samad, T, Abe, M, Abraham, N, Acheampong, S, Achiri, P, Acosta, JA, Adeleke, A, Adell, V, Adewuyi-Dalton, R, Adnan, N, Africano, A, Agharazii, M, Aguilar, F, Aguilera, A, Ahmad, M, Ahmad, MK, Ahmad, NA, Ahmad, NH, Ahmad, NI, Ahmad Miswan, N, Ahmad Rosdi, H, Ahmed, I, Ahmed, S, Aiello, J, Aitken, A, AitSadi, R, Aker, S, Akimoto, S, Akinfolarin, A, Akram, S, Alberici, F, Albert, C, Aldrich, L, Alegata, M, Alexander, L, Alfaress, S, Alhadj Ali, M, Ali, A, Alicic, R, Aliu, A, 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Yahaya, H, Yalamanchili, H, Yamada, A, Yamada, N, Yamagata, K, Yamaguchi, M, Yamaji, Y, Yamamoto, A, Yamamoto, S, Yamamoto, T, Yamanaka, A, Yamano, T, Yamanouchi, Y, Yamasaki, N, Yamasaki, Y, Yamashita, C, Yamauchi, T, Yan, Q, Yanagisawa, E, Yang, F, Yang, L, Yano, S, Yao, S, Yao, Y, Yarlagadda, S, Yasuda, Y, Yiu, V, Yokoyama, T, Yoshida, S, Yoshidome, E, Yoshikawa, H, Young, A, Young, T, Yousif, V, Yu, H, Yu, Y, Yuasa, K, Yusof, N, Zalunardo, N, Zander, B, Zani, R, Zappulo, F, Zayed, M, Zemann, B, Zettergren, P, Zhang, H, Zhang, L, Zhang, N, Zhang, X, Zhao, J, Zhao, L, Zhao, S, Zhao, Z, Zhong, H, Zhou, N, Zhou, S, Zhu, L, Zhu, S, Zietz, M, Zippo, M, Zirino, F, and Zulkipli, FH
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- 2024
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24. Control of stem cell behavior by CLE-JINGASA signaling in the shoot apical meristem in Marchantia polymorpha
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Takahashi, Go, Kiyosue, Tomohiro, and Hirakawa, Yuki
- Published
- 2023
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25. Zibotentan in combination with dapagliflozin compared with dapagliflozin in patients with chronic kidney disease (ZENITH-CKD): a multicentre, randomised, active-controlled, phase 2b, clinical trial
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Heerspink, Hiddo J L, Kiyosue, Arihiro, Wheeler, David C, Lin, Min, Wijkmark, Emma, Carlson, Glenn, Mercier, Anne-Kristina, Åstrand, Magnus, Ueckert, Sebastian, Greasley, Peter J, and Ambery, Phil
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- 2023
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26. Impact of heart failure severity and major bleeding events after percutaneous coronary intervention on subsequent major adverse cardiac events
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Ikebe, So, Ishii, Masanobu, Otsuka, Yasuhiro, Nakamura, Taishi, Tsujita, Kenichi, Matoba, Tetsuya, Kohro, Takahide, Oba, Yusuke, Kabutoya, Tomoyuki, Imai, Yasushi, Kario, Kazuomi, Kiyosue, Arihiro, Mizuno, Yoshiko, Nochioka, Kotaro, Nakayama, Masaharu, Iwai, Takamasa, Miyamoto, Yoshihiro, Sato, Hisahiko, Akashi, Naoyuki, Fujita, Hideo, and Nagai, Ryozo
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- 2023
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27. BNP level predicts bleeding event in patients with heart failure after percutaneous coronary intervention
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Kazuomi Kario, Ryozo Nagai, Kenichi Tsujita, Yoshihiro Miyamoto, Yasushi Imai, Tomoyuki Kabutoya, Hideo Fujita, Kotaro Nochioka, Koichi Kaikita, Tetsuya Matoba, Arihiro Kiyosue, Taishi Nakamura, Masanobu Ishii, Yasuhiro Otsuka, So Ikebe, Takahide Kohro, Yusuke Oba, Yoshiko Mizuno, Masaharu Nakayama, Takamasa Iwai, Hisahiko Sato, and Naoyuki Akashi
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective This study aimed to investigate the association between heart failure (HF) severity measured based on brain natriuretic peptide (BNP) levels and future bleeding events after percutaneous coronary intervention (PCI).Background The Academic Research Consortium for High Bleeding Risk presents a bleeding risk assessment for antithrombotic therapy in patients after PCI. HF is a risk factor for bleeding in Japanese patients.Methods Using an electronic medical record-based database with seven tertiary hospitals in Japan, this retrospective study included 7160 patients who underwent PCI between April 2014 and March 2020 and who completed a 3-year follow-up and were divided into three groups: no HF, HF with high BNP level and HF with low BNP level. The primary outcome was bleeding events according to the Global Use of Streptokinase and t-PA for Occluded Coronary Arteries classification of moderate and severe bleeding. The secondary outcome was major adverse cardiovascular events (MACE). Furthermore, thrombogenicity was measured using the Total Thrombus-Formation Analysis System (T-TAS) in 536 consecutive patients undergoing PCI between August 2013 and March 2017 at Kumamoto University Hospital.Results Multivariate Cox regression showed that HF with high BNP level was significantly associated with bleeding events, MACE and all-cause death. In the T-TAS measurement, the thrombogenicity was lower in patients with HF with high BNP levels than in those without HF and with HF with low BNP levels.Conclusions HF with high BNP level is associated with future bleeding events, suggesting that bleeding risk might differ depending on HF severity.
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- 2023
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28. A Common Generalization of Budget Games and Congestion Games.
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Fuga Kiyosue and Kenjiro Takazawa
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- 2022
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29. Imaging Anatomy: Text and Atlas Volume 3: Bones, Joints, Muscles, Vessels, and Nerves
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Farhood Saremi, Dakshesh Patel, Damian Sanchez-Quintana, Hiro Kiyosue, Meng Law, R. Shane Tubbs
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- 2023
30. Imaging three-dimensional dynamics of plasma membrane structures using ultrathin plane illumination microscopy
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Mimori-Kiyosue, Yuko, primary
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- 2023
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31. List of contributors
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Agashe, Atharva, primary, Chung, Steve, additional, Ditlev, Jonathon A., additional, Drab, Mitja, additional, Fujioka, Toshifumi, additional, Gov, Nir S., additional, Hernandez-Padilla, Christian, additional, Hu, Hooi Ting, additional, Hubert, Madlen, additional, Iglič, Aleš, additional, Ijuin, Takeshi, additional, Inaba, Takehiko, additional, Inoue, Takanari, additional, Itoh, Toshiki, additional, Janewanthanakul, Suphamon, additional, Kawasaki, Asami, additional, Kitamata, Manabu, additional, Kitao, Akio, additional, Kralj-Iglič, Veronika, additional, Larsson, Elin, additional, Lee, Shin Yong, additional, Liu, Kang Cheng, additional, Liyanage, Leshani Ahangama, additional, Lundmark, Richard, additional, Mesarec, Luka, additional, Mimori-Kiyosue, Yuko, additional, Morita, Eiji, additional, Mukai, Kojiro, additional, Nagano, Makoto, additional, Nain, Amrinder S., additional, Nakamura, Yoshikazu, additional, Nakatsu, Fubito, additional, Nishimura, Tamako, additional, Osuga, Mitsuo, additional, Rakhaminov, Gaddy, additional, Ravid, Yoav, additional, Razavi, Shiva, additional, Sadhu, Raj Kumar, additional, Sasaki, Takehiko, additional, Shigene, Kei, additional, Sim, Pei Fang, additional, Suetsugu, Shiro, additional, Taguchi, Tomohiko, additional, Takeda, Tetsuya, additional, Takei, Kohji, additional, Takemura, Kazuhiro, additional, Toshima, Jiro, additional, Toshima, Junko Y., additional, Tsujita, Kazuya, additional, Uchida, Yasunori, additional, Wan Mohamad Noor, Wan Nurul Izzati, additional, Watanabe, Naoki, additional, Yamada, Hiroshi, additional, Yamaguchi, Hideki, additional, Yamamoto, Yuko, additional, and Yasuhara, Kazuma, additional
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- 2023
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32. A phase 2 randomized, double-blind trial of ART-001, a selective PI3Kα inhibitor, for the treatment of slow-flow vascular malformations.
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Ozeki, Michio, Tanaka, Akira, Kuniyeda, Kanako, Nozaki, Taiki, Fujino, Akihiro, Nomura, Tadashi, Uemura, Naoto, Suenobu, Souichi, Aramaki-Hattori, Noriko, Hayashi, Ayato, Kato, Aiko, Kiyosue, Hiro, Imagawa, Kotaro, Nagao, Munetomo, Shimizu, Fumiaki, Ochi, Junko, Horiuchi, Saya, Ohyama, Tetsuji, Ando, Haruhi, and Nagabukuro, Hiroshi
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LYMPHATIC abnormalities ,CHILD patients ,DRUG development ,QUALITY of life ,CONFIDENCE intervals - Abstract
Background: In patients with slow-flow vascular malformations (SFVMs) including venous malformations (VM), lymphatic malformations (LM) or Klippel–Trenaunay Syndrome (KTS), somatic gain-of-function mutations in genes encoding phosphatidyl inositol 3-kinase alpha (PI3Kα, gene name PIK3CA) have been identified. A phase 2 study was conducted with the patients to assess the efficacy and safety of ART-001 (serabelisib), an orally available selective PI3Kα inhibitor. Methods: This is a multicenter, randomized, double-blind, proof-of-concept, phase 2 trial. Eligible participants were patients aged 2 years and older, diagnosed either with VM, LM or KTS. Participants were administered either 50 or 100 mg of ART-001 for 24 weeks. The primary endpoint was the response rate defined as the proportion of participants who achieved ≥ 20% reduction in lesion volume at week 24. Secondary endpoints include safety, pharmacokinetics, pain, and quality of life scores. Results: Thirty-five patients (median age: 14 years old; VM, n = 17, KTS, n = 13 and LM, n = 5) were randomly assigned and received treatment (50 mg, n = 17 and 100 mg, n = 18). ART-001 showed a response rate: 29.4% (95% confidence interval 10.3–56.0%) at 50 mg and 33.3% (13.3–59.0%) at 100 mg. Mean lesion volume reductions at 50 mg and 100 mg were − 2.3% (95% CI − 14.3 to 9.6%) and − 12.6% (− 25.3 to 0.06%), respectively. No drug-related serious adverse events were observed. Treatment-emergent adverse events were generally mild to moderate and transient. Pharmacokinetic profiles were similar between pediatric and adolescent/adult patients except for lower C
trough levels in pediatric patients. Conclusion: ART-001 was effective and well-tolerated in patients with SFVMs. These results support the further development of ART-001 in SFVMs and other PIK3CA-related overgrowth syndromes to confirm clinical benefits and long-term safety. Trial registration: Japan Registry of Clinical Trial, jRCT2071210027. Registered May 25 2021,https://jrct.niph.go.jp/en-latest-detail/jRCT2071210027 [ABSTRACT FROM AUTHOR]- Published
- 2025
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33. High D-Dimer Concentration Is a Significant Independent Prognostic Factor in Patients with Acute Large Vessel Occlusion Undergoing Endovascular Thrombectomy
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Hisamitsu, Yoshinori, Kubo, Takeshi, Fudaba, Hirotaka, Sugita, Kenji, Fujiki, Minoru, Ide, Satomi, Kiyosue, Hiro, and Hori, Yuzo
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- 2022
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34. Theoretical model of membrane protrusions driven by curved active proteins
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Yoav Ravid, Samo Penič, Yuko Mimori-Kiyosue, Shiro Suetsugu, Aleš Iglič, and Nir S. Gov
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cell membrane ,curved inclusions ,Monte-Carlo simulations ,closed vesicle shapes ,cell motility ,filopodia ,Biology (General) ,QH301-705.5 - Abstract
Eukaryotic cells intrinsically change their shape, by changing the composition of their membrane and by restructuring their underlying cytoskeleton. We present here further studies and extensions of a minimal physical model, describing a closed vesicle with mobile curved membrane protein complexes. The cytoskeletal forces describe the protrusive force due to actin polymerization which is recruited to the membrane by the curved protein complexes. We characterize the phase diagrams of this model, as function of the magnitude of the active forces, nearest-neighbor protein interactions and the proteins’ spontaneous curvature. It was previously shown that this model can explain the formation of lamellipodia-like flat protrusions, and here we explore the regimes where the model can also give rise to filopodia-like tubular protrusions. We extend the simulation with curved components of both convex and concave species, where we find the formation of complex ruffled clusters, as well as internalized invaginations that resemble the process of endocytosis and macropinocytosis. We alter the force model representing the cytoskeleton to simulate the effects of bundled instead of branched structure, resulting in shapes which resemble filopodia.
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- 2023
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35. A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function
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Heerspink, Hiddo J.L., Wheeler, David C., Chertow, Glenn, Correa-Rotter, Ricardo, Greene, Tom, Hou, Fan Fan, McMurray, John, Rossing, Peter, Toto, Robert, Stefansson, Bergur, Langkilde, Anna Maria, Maffei, L.E., Raffaele, P., Solis, S.E., Arias, C.A., Aizenberg, D., Luquez, C., Zaidman, C., Cluigt, N., Mayer, M., Alvarisqueta, A., Wassermann, A., Maldonado, R., Bittar, J., Maurich, M., Gaite, L.E., Garcia, N., Sivak, L., Ramallo, P.O., Santos, J.C., Garcia Duran, R., Oddino, J.A., Maranon, A., Maia, L.N., Avila, D.D., Barros, E.J.G., Vidotti, M.H., Panarotto, D., Noronha, I.D.L., Turatti, L.A.A., Deboni, L., Canziani, M.E., Riella, M.C., Bacci, M.R., Paschoalin, R.P., Franco, R.J., Goldani, J.C., St-Amour, E., Steele, A.W., Goldenberg, R., Pandeya, S., Bajaj, H., Cherney, D., Kaiser, S.M., Conway, J.R., Chow, S.S., Bailey, G., Lafrance, J., Winterstein, J., Cournoyer, S., Gaudet, D., Madore, F., Houlden, R.L., Dowell, A., Langlois, M., Muirhead, N., Khandwala, H., Levin, A., Hou, F., Xue, Y., Zuo, L., Hao, C., Ni, Z., Xing, C., Chen, N., Dong, Y., Zhou, R., Xiao, X., Zou, Y., Wang, C., Liu, B., Chen, Q., Lin, M., Luo, Q., Zhang, D., Wang, J., Chen, M., Wang, X., Zhong, A., Dong, J., Zhu, C., Yan, T., Luo, P., Ren, Y., Pai, P., Li, D., Zhang, R., Zhang, J., Xu, M., Zhuang, Y., Kong, Y., Yao, X., Peng, X., Persson, F.I., Hansen, T.K., Borg, R., Pedersen Bjergaard, U., Hansen, D., Hornum, M., Haller, H., Klausmann, G., Tschope, D., Kruger, T., Gross, P., Hugo, C., Obermuller, N., Rose, L., Mertens, P., Zeller-Stefan, H., Fritsche, A., Renders, L., Muller, J., Budde, K., Schroppel, B., Wittmann, I., Voros, P., Dudas, M., Tabak, G.A., Kirschner, R., Letoha, A., Balku, I., Hermanyi, Z., Zakar, G., Mezei, I., Nagy, G.G., Lippai, J., Nemeth, A., Khullar, D., Gowdaiah, P.K., Fernando Mervin, E., Rao, V.A., Dewan, D., Goplani, K., Maddi, V.S.K., Vyawahare, M.S., Pulichikkat, R.K., Pandey, R., Sonkar, S.K., Gupta, V.K., Agarwal, S., Asirvatham, A.J., Ignatius, A., Chaubey, S., Melemadathil, S., Alva, H., Kadam, Y., Shimizu, H., Sueyoshi, A., Takeoka, H., Abe, Y., Imai, T., Onishi, Y., Fujita, Y., Tokita, Y., Oura, M., Makita, Y., Idogaki, A., Koyama, R., Kikuchi, H., Kashihara, N., Hayashi, T., Ando, Y., Tanaka, T., Shimizu, M., Hidaka, S., Gohda, T., Tamura, K., Abe, M., Kamijo, Y., Imasawa, T., Takahashi, Y., Nakayama, M., Tomita, M., Hirano, F., Fukushima, Y., Kiyosue, A., Kurioka, S., Imai, E., Kitagawa, K., Waki, M., Wada, J., Uehara, K., Iwatani, H., Ota, K., Shibazaki, S., Katayama, K., Narita, I., Iinuma, M., Matsueda, S., Sasaki, S., Yokochi, A., Tsukamoto, T., Yoshimura, T., Kang, S., Lee, S., Lim, C.S., Chin, H., Joo, K.W., Han, S.Y., Chang, T.I., Park, S., Park, H., Park, C.W., Han, B.G., Cha, D.R., Yoon, S.A., Kim, W., Kim, S.W., Ryu, D., Correa Rotter, R., Irizar Santana, S.S., Hernandez Llamas, G., Valdez Ortiz, R., Secchi Nicolas, N.C., Gonzalez Galvez, G., Lazcano Soto, J.R., Bochicchio Riccardelli, T., Bayram Llamas, E.A., Ramos Ibarra, D.R., Melo, M.G.S., Gonzalez Gonzalez, J.G., Sanchez Mijangos, J.H., Madero Robalo, M., Garcia Castillo, A., Manrique, H.A., Farfan, J.C., Vargas, R., Valdivia, A., Dextre, A., Escudero, E., Calderon Ticona, J.R., Gonzales, L., Villena, J., Leon, L., Molina, G., Saavedra, A., Garrido, E., Arbanil, H., Vargas Marquez, S., Rodriguez, J., Isidto, R., Villaflor, A.J., Gumba, M.A., Tirador, L., Comia, R.S., Sy, R.A., Guanzon, M.L.V.V., Aquitania, G., De Asis, N.C., Silva, A.A., Romero, C.M., Lim, M.E., Danguilan, R.A., Nowicki, M., Rudzki, H., Landa, K., Kucharczyk-Bauman, I., Gogola-Migdal, B., Golski, M., Olech-Cudzik, A., Stompor, T., Szczepanik, T., Miklaszewicz, B., Sciborski, R., Kuzniewski, M., Ciechanowski, K., Wronska, D., Klatko, W., Mazur, S., Popenda, G., Myslicki, M., Bolieva, L.Z., Berns, S., Galyavich, A., Abissova, T., Karpova, I., Platonov, D., Koziolova, N., Kvitkova, L., Nilk, R., Medina, T., Rebrov, A., Rossovskaya, M., Sinitsina, I., Vishneva, E., Zagidullin, N., Novikova, T., Krasnopeeva, N., Magnitskaya, O., Antropenko, N., Batiushin, M., Escudero Quesada, V., Barrios Barrea, C., Espinel Garauz, E., Cruzado Garrit, J.M., Morales Portillo, C., Gorriz Teruel, J.L., Cigarran Guldris, S., Praga Terente, M., Robles Perez-Monteoliva, N.R., Tinahones Madueno, F.J., Soto Gonzalez, A., Diaz Rodriguez, C., Furuland, H., Saeed, A., Dreja, K., Spaak, J., Bruchfeld, A., Kolesnyk, M., Levchenko, O., Pyvovarova, N., Stus, V., Doretskyy, V., Korobova, N., Horoshko, O., Katerenchuk, I., Mostovoy, Y.M., Orynchak, M., Legun, O., Dudar, I., Bilchenko, O., Andreychyn, S., Levchenko, A., Zub, L., Tereshchenko, N., Topchii, I., Ostapenko, T., Bezuglova, S., Kopytsya, M., Turenko, O., Mark, P., Barratt, J., Bhandari, S., Fraser, D., Kalra, P., Kon, S.P., Mccafferty, K., Mikhail, A., Alvarado, O.P., Anderson, R., Andrawis, N.S., Arif, A., Benjamin, S.A., Bueso, G., Busch, R.S., Carr, K.W., Crawford, P., Daboul, N., De La Calle, G.M., Delgado, B., Earl, J., El-Shahawy, M.A., Graf, R.J., Greenwood, G., Guevara, A., Wendland, E.M., Mayfield, R.K., Montero, M., Morin, D.J., Narayan, P., Numrungroad, V., Reddy, A.C., Reddy, R., Samson, M.B., Trejo, R., Butcher, M.B., Wise, J.K., Zemel, L.R., Raikhel, M., Weinstein, D., Hernandez, P., Wynne, A., Khan, B.V., Sterba, G.A., Jamal, A., Ross, D., Rovner, S.F., Tan, A., Ovalle, F., Patel, R.J., Talano, J., Patel, D.R., Burgner, A., Aslam, N., Elliott, M., Goral, S., Jovanovich, A., Manley, J.A., Umanath, K., Waguespack, D., Weiner, D., Yu, M., Schneider, L., Jalal, D., Le, T., Nguyen, N., Nguyen, H., Nguyen, D., Nguyen, V., Do, T., Chu, P., Ta, D., Tran, N., Pham, B., Pfeffer, Marc A., Pocock, Stuart, Swedberg, Karl, Rouleau, Jean L., Chaturvedi, Nishi, Ivanovich, Peter, Levey, Andrew S., Christ-Schmidt, Heidi, Held, Claes, Christersson, Christina, Mann, Johannes, Varenhorst, Christoph, Cherney, David, Postmus, Douwe, Stefánsson, Bergur V., Chertow, Glenn M., Dwyer, Jamie P., Kosiborod, Mikhail, McMurray, John J.V., Sjöström, C. David, and Toto, Robert D.
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- 2022
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36. Posterior (Neural) Branches from the Proximal ECA
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Kiyosue, Hiro, Matsumaru, Yuji, and Kiyosue, Hiro, editor
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- 2020
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37. Maxillary Artery
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Kiyosue, Hiro, Tanoue, Shuichi, and Kiyosue, Hiro, editor
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- 2020
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38. Superficial Arteries from the Distal ECA
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Kiyosue, Hiro and Kiyosue, Hiro, editor
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- 2020
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39. External Carotid Artery
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Kiyosue, Hiro and Kiyosue, Hiro, editor
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- 2020
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40. Anterior (Visceral) Branches from the Proximal ECA (Superior Thyroidal, Lingual, and Facial Arterial System)
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Kiyosue, Hiro and Kiyosue, Hiro, editor
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- 2020
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41. Actin Filaments Couple the Protrusive Tips to the Nucleus through the I‐BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers
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Apratim Mukherjee, Jonathan Emanuel Ron, Hooi Ting Hu, Tamako Nishimura, Kyoko Hanawa‐Suetsugu, Bahareh Behkam, Yuko Mimori‐Kiyosue, Nir Shachna Gov, Shiro Suetsugu, and Amrinder Singh Nain
- Subjects
actin ,cell forces ,extracellular matrice nanofibers ,IRSp53 ,membrane curvature ,protrusions ,Science - Abstract
Abstract The cell migration cycle, well‐established in 2D, proceeds with forming new protrusive structures at the cell membrane and subsequent redistribution of contractile machinery. Three‐dimensional (3D) environments are complex and composed of 1D fibers, and 1D fibers are shown to recapitulate essential features of 3D migration. However, the establishment of protrusive activity at the cell membrane and contractility in 1D fibrous environments remains partially understood. Here the role of membrane curvature regulator IRSp53 is examined as a coupler between actin filaments and plasma membrane during cell migration on single, suspended 1D fibers. IRSp53 depletion reduced cell‐length spanning actin stress fibers that originate from the cell periphery, protrusive activity, and contractility, leading to uncoupling of the nucleus from cellular movements. A theoretical model capable of predicting the observed transition of IRSp53‐depleted cells from rapid stick‐slip migration to smooth and slower migration due to reduced actin polymerization at the cell edges is developed, which is verified by direct measurements of retrograde actin flow using speckle microscopy. Overall, it is found that IRSp53 mediates actin recruitment at the cellular tips leading to the establishment of cell‐length spanning fibers, thus demonstrating a unique role of IRSp53 in controlling cell migration in 3D.
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- 2023
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42. Potential value of saline-induced Pd/Pa ratio in patients with coronary artery stenosis
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Hiroyuki Kiriyama, Arihiro Kiyosue, Shun Minatsuki, Takuya Kawahara, Susumu Katsushika, Tatsuya Kamon, Kazutoshi Hirose, Hiroki Shinohara, Mizuki Miura, Akihito Saito, Hironobu Kikuchi, Satoshi Kodera, Masaru Hatano, Jiro Ando, Masahiro Myojo, Nobuhiko Itoh, Keisuke Yamamoto, Hiroshi Ikenouchi, Norifumi Takeda, and Issei Komuro
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saline-induced Pd/Pa ratio ,resting full-cycle ratio ,fractional flow reserve ,epicardial coronary artery ,physiological assessment ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundFractional flow reserve (FFR) is the current gold standard for identifying myocardial ischemia in individuals with coronary artery stenosis. However, FFR is not penetrated as much worldwide due to time consumption, costs associated with adenosine, FFR-related discomfort, and complications. Resting physiological indexes may be widely accepted alternatives to FFR, while the discrepancies with FFR were found in up to 20% of lesions. The saline-induced Pd/Pa ratio (SPR) is a new simplified option for evaluating coronary stenosis. However, the clinical implication of SPR remains unclear.ObjectivesIn the present study, we aimed to compare the accuracies of SPR and resting full-cycle ratio (RFR) and to investigate the incremental value of SPR in clinical practice.MethodsIn this multicenter prospective study, 112 coronary lesions (105 patients) were evaluated by SPR, RFR, and FFR.ResultsThe overall median age was 71 years, and 84.8% were men. SPR was correlated more strongly with FFR than with RFR (r = 0.874 vs. 0.713, respectively; p < 0.001). Using FFR < 0.80 as the reference standard variable, the area under the receiver-operating characteristic (ROC) curve for SPR was superior to that of RFR (0.932 vs. 0.840, respectively; p = 0.009).ConclusionSaline-induced Pd/Pa ratio predicted FFR more accurately than RFR. SPR could be an alternative method for evaluating coronary artery stenosis and further investigation including elucidation of the mechanism of SPR is needed (225 words).
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- 2023
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43. Hyperuricemia predicts increased cardiovascular events in patients with chronic coronary syndrome after percutaneous coronary intervention: A nationwide cohort study from Japan
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Naoyuki Akashi, Masanari Kuwabara, Tetsuya Matoba, Takahide Kohro, Yusuke Oba, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario, Arihiro Kiyosue, Yoshiko Mizuno, Kotaro Nochioka, Masaharu Nakayama, Takamasa Iwai, Yoko Nakao, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Masanobu Ishii, Taishi Nakamura, Kenichi Tsujita, Hisahiko Sato, Hideo Fujita, and Ryozo Nagai
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hyperuricemia ,serum uric acid ,chronic coronary syndrome ,percutaneous coronary intervention ,real-world database ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundThe causal relationship between hyperuricemia and cardiovascular diseases is still unknown. We hypothesized that hyperuricemic patients after percutaneous coronary intervention (PCI) had a higher risk of major adverse cardiovascular events (MACE).MethodsThis was a large-scale multicenter cohort study. We enrolled patients with chronic coronary syndrome (CCS) after PCI between April 2013 and March 2019 using the database from the Clinical Deep Data Accumulation System (CLIDAS), and compared the incidence of MACE, defined as a composite of cardiovascular death, myocardial infarction, and hospitalization for heart failure, between hyperuricemia and non-hyperuricemia groups.ResultsIn total, 9,936 patients underwent PCI during the study period. Of these, 5,138 patients with CCS after PCI were divided into two group (1,724 and 3,414 in the hyperuricemia and non-hyperuricemia groups, respectively). The hyperuricemia group had a higher prevalence of hypertension, atrial fibrillation, history of previous hospitalization for heart failure, and baseline creatinine, and a lower prevalence of diabetes than the non-hyperuricemia group, but the proportion of men and age were similar between the two groups. The incidence of MACE in the hyperuricemia group was significantly higher than that in the non-hyperuricemia group (13.1 vs. 6.4%, log-rank P < 0.001). Multivariable Cox regression analyses revealed that hyperuricemia was significantly associated with increased MACE [hazard ratio (HR), 1.52; 95% confidential interval (CI), 1.23–1.86] after multiple adjustments for age, sex, body mass index, estimated glomerular filtration rate, left main disease or three-vessel disease, hypertension, diabetes mellitus, dyslipidemia, history of myocardial infarction, and history of hospitalization for heart failure. Moreover, hyperuricemia was independently associated with increased hospitalization for heart failure (HR, 2.19; 95% CI, 1.69–2.83), but not cardiovascular death or myocardial infarction after multiple adjustments. Sensitive analyses by sex and diuretic use, B-type natriuretic peptide level, and left ventricular ejection fraction showed similar results.ConclusionCLIDAS revealed that hyperuricemia was associated with increased MACE in patients with CCS after PCI. Further clinical trials are needed whether treating hyperuricemia could reduce cardiovascular events or not.
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- 2023
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44. Imaging Anatomy: Text and Atlas Volume 2: Abdomen and Pelvis
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Farhood Saremi, Damian Sanchez-Quintana, Hiro Kiyosue, Dakshesh Patel, Meng Law, R. Shane Tubbs
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- 2022
45. Angiographic features and transarterial embolization of retained placenta with abnormal vaginal bleeding
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Ryo Takaji, Hiro Kiyosue, Miyuki Maruno, Norio Hongo, Ryuichi Shimada, Satomi Ide, Kohei Tokuyama, Mamiko Okamoto, Yasushi Kawano, and Yoshiki Asayama
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Retained placenta ,Angiography ,Transarterial embolization ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Objectives To clarify characteristic angiographic features and clinical efficacy of selective transarterial embolization (TAE) of retained placenta with abnormal vaginal bleeding. Methods The study cohort comprised 22 patients (mean age, 33.5 years; range, 22–24 years) who underwent selective TAE for retained placenta with abnormal bleeding between January 2018 and December 2020 at our institution. Angiographic images were reviewed by two certified radiologists with consensus. Medical records were reviewed to evaluate the efficacy of TAE. Angiographic features of retained placenta, technical success (disappearance of abnormal findings on angiography), complications, clinical outcomes (hemostatic effects and recurrent bleeding) were evaluated. Results Pelvic angiography showed a dilated vascular channel mimicking arteriovenous fistulas or an aneurysm contiguous with dilated uterine arteries in the mid-arterial–capillary phase in 20 patients; it showed contrast brush in the remaining two patients. TAE technical success was achieved in all patients. No major complications were observed in any patients. Fifteen patients were followed up with expectant management after TAE; all but one patient showed no re-bleeding during the follow-up period (mean follow-up interval, 3.4 months; range, 1–17 months). One patient showed minor rebleeding, which resolved spontaneously. Seven patients underwent scheduled hysteroscopic resection within 1 week after TAE, and no excessive bleeding was observed during or after the surgical procedure in all seven patients. Conclusions The characteristic angiographic feature of retained placenta is “dilated vascular channel that mimic low flow AVM.” TAE is a safe and effective treatment to manage retained placenta with abnormal bleeding.
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- 2021
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46. Vessel Occlusion using Hydrogel-Coated versus Nonhydrogel Embolization Coils in Peripheral Arterial Applications: A Prospective, Multicenter, Randomized Trial
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Hongo, Norio, Kiyosue, Hiro, Ota, Shinichi, Nitta, Norihisa, Koganemaru, Masamichi, Inoue, Masanori, Nakatsuka, Seishi, Osuga, Keigo, Anai, Hiroshi, Yasumoto, Taku, Tanoue, Shuichi, Maruno, Miyuki, Kamei, Noritaka, Kichikawa, Kimihiko, Abe, Toshi, Hasebe, Terumitsu, and Asayama, Yoshiki
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- 2021
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47. Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells
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Nishimura, Tamako, Oyama, Takuya, Hu, Hooi Ting, Fujioka, Toshifumi, Hanawa-Suetsugu, Kyoko, Ikeda, Kazutaka, Yamada, Sohei, Kawana, Hiroki, Saigusa, Daisuke, Ikeda, Hiroki, Kurata, Rie, Oono-Yakura, Kayoko, Kitamata, Manabu, Kida, Kazuki, Hikita, Tomoya, Mizutani, Kiyohito, Yasuhara, Kazuma, Mimori-Kiyosue, Yuko, Oneyama, Chitose, Kurimoto, Kazuki, Hosokawa, Yoichiroh, Aoki, Junken, Takai, Yoshimi, Arita, Makoto, and Suetsugu, Shiro
- Published
- 2021
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48. Effect of canagliflozin on N-terminal pro-brain natriuretic peptide in patients with type 2 diabetes and chronic heart failure according to baseline use of glucose-lowering agents
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Atsushi Tanaka, Shigeru Toyoda, Takumi Imai, Kazuki Shiina, Hirofumi Tomiyama, Yasushi Matsuzawa, Takahiro Okumura, Yumiko Kanzaki, Katsuya Onishi, Arihiro Kiyosue, Masami Nishino, Yasushi Sakata, Koichi Node, and the CANDLE trial investigators
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Type 2 diabetes ,Chronic heart failure ,Sodium–glucose cotransporter 2 inhibitor ,Metformin ,Dipeptidyl peptidase-4 inhibitor ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of a deterioration in heart failure (HF) and mortality in patients with a broad range of cardiovascular risks. Recent guidelines recommend considering the use of SGLT2 inhibitors in patients with type 2 diabetes (T2D) and HF, irrespective of their glycemic control status and background use of other glucose-lowering agents including metformin. However, only a small number of studies have investigated whether the effects of SGLT2 inhibitor in these patients differ by the concomitant use of other glucose-lowering agents. Methods This was a post-hoc analysis of the CANDLE trial (UMIN000017669), an investigator-initiated, multicenter, open-label, randomized, controlled trial. The primary aim of the analysis was to assess the effect of 24 weeks of treatment with canagliflozin, relative to glimepiride, on N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration in patients with T2D and clinically stable chronic HF. In the present analysis, the effect of canagliflozin on NT-proBNP concentration was assessed in the patients according to their baseline use of other glucose-lowering agents. Results Almost all patients in the CANDLE trial presented as clinically stable (New York Heart Association class I to II), with about 70% of participants having HF with a preserved ejection fraction phenotype (defined as a left ventricular ejection fraction ≥ 50%) at baseline. Of the 233 patients randomized to either canagliflozin (100 mg daily) or glimepiride (starting dose 0.5 mg daily), 85 (36.5%) had not been taking any glucose-lowering agents at baseline (naïve). Of the 148 patients who had been taking at least one glucose-lowering agent at baseline (non-naïve), 44 (29.7%) and 127 (85.8%) had received metformin or a dipeptidyl dipeptidase-4 (DPP-4) inhibitor, respectively. The group ratio (canagliflozin vs. glimepiride) of proportional changes in the geometric means of NT-proBNP concentration was 0.95 (95% confidence interval [CI] 0.76 to 1.18, p = 0.618) for the naïve subgroup, 0.92 (95% CI 0.79 to1.07, p = 0.288) for the non-naïve subgroup, 0.90 (95% CI 0.68 to 1.20, p = 0.473) for the metformin-user subgroup, and 0.91 (95% CI 0.77 to 1.08, p = 0.271) for the DPP-4 inhibitor-user subgroup. No heterogeneity in the effect of canagliflozin, relative to glimepiride, on NT-proBNP concentration was observed in the non-naïve subgroups compared to that in the naïve subgroup. Conclusion The impact of canagliflozin treatment on NT-proBNP concentration appears to be independent of the background use of diabetes therapy in the patient population examined. Trial registration University Medical Information Network Clinical Trial Registry, number 000017669. Registered on May 25, 2015
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- 2021
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49. A Common Generalization of Budget Games and Congestion Games
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Kiyosue, Fuga, primary and Takazawa, Kenjiro, additional
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- 2022
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50. Location of embolization affects patency after coil embolization for pulmonary arteriovenous malformations: importance of time-resolved magnetic resonance angiography for diagnosis of patency
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Shimohira, Masashi, Kiyosue, Hiro, Osuga, Keigo, Gobara, Hideo, Kondo, Hiroshi, Nakazawa, Tetsuro, Matsui, Yusuke, Hamamoto, Kohei, Ishiguro, Tomoya, Maruno, Miyuki, Sugimoto, Koji, Koganemaru, Masamichi, Kitagawa, Akira, and Yamakado, Koichiro
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- 2021
- Full Text
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