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29 results on '"Kithcart, Aaron P."'

1. Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone

Author

Dunn, Michael E., Kithcart, Aaron, Kim, Jee Hae, Ho, Andre Jo-Hao, Franklin, Matthew C., Romero Hernandez, Annabel, de Hoon, Jan, Botermans, Wouter, Meyer, Jonathan, Jin, Ximei, Zhang, Dongqin, Torello, Justin, Jasewicz, Daniel, Kamat, Vishal, Garnova, Elena, Liu, Nina, Rosconi, Michael, Pan, Hao, Karnik, Satyajit, Burczynski, Michael E., Zheng, Wenjun, Rafique, Ashique, Nielsen, Jonas B., De, Tanima, Verweij, Niek, Pandit, Anita, Locke, Adam, Chalasani, Naga, Melander, Olle, Schwantes-An, Tae-Hwi, Baras, Aris, Lotta, Luca A., Musser, Bret J., Mastaitis, Jason, Devalaraja-Narashimha, Kishor B., Rankin, Andrew J., Huang, Tammy, Herman, Gary, Olson, William, Murphy, Andrew J., Yancopoulos, George D., Olenchock, Benjamin A., and Morton, Lori

Published
2024
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7. EFFECTS OF REGN5381, A NATRIURETIC PEPTIDE RECEPTOR 1 AGONIST ANTIBODY, IN HYPERTENSIVE MOUSE MODELS AND MILDLY HYPERTENSIVE BUT OTHERWISE HEALTHY ADULTS IN A PHASE 1 FIRST-IN-HUMAN STUDY

Author

Kithcart, Aaron P., Devalaraja-Narashimha, Kishor, Liu, Laura, Jin, Ximei, Torello, Justin, Zhang, Dongqin, Shekhar, Akshay, De Hoon, Jan, Botermans, Wouter, Herman, Gary, Cheng, Xiping, Pawaskar, Dipti, Gopal, Srihari, Dunn, Michael, Morton, Lori, and Olenchock, Ben

Published
2024
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13. The Supply and Demand of the Cardiovascular Workforce: Striking the Right Balance

Author

Narang, Akhil, Sinha, Shashank S., Rajagopalan, Bharath, Ijioma, Nkechinyere N., Jayaram, Natalie, Kithcart, Aaron P., Tanguturi, Varsha K., and Cullen, Michael W.

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, ComputerSystemsOrganization_COMPUTERSYSTEMIMPLEMENTATION, education, Cardiology, Workforce, Article, United States
Abstract

As the burden of cardiovascular disease in the United States continues to increase, uncertainty remains on how well-equipped the cardiovascular workforce is to meet the challenges that lie ahead. In a time when health care is rapidly shifting, numerous factors affect the supply and demand of the cardiovascular workforce. This Council Commentary critically examines several factors that influence the cardiovascular workforce. These include current workforce demographics and projections, evolving health care and practice environments, and the increasing burden of cardiovascular disease. Finally, we propose 3 strategies to optimize the workforce. These focus on cardiovascular disease prevention, the effective utilization of the cardiovascular care team, and alterations to the training pathway for cardiologists.

Published
2016

15. Improving the Appropriate Use of Transthoracic Echocardiography

Author

Bhatia, R. Sacha, primary, Ivers, Noah M., additional, Yin, X. Cindy, additional, Myers, Dorothy, additional, Nesbitt, Gillian C., additional, Edwards, Jeremy, additional, Yared, Kibar, additional, Wadhera, Rishi K., additional, Wu, Justina C., additional, Kithcart, Aaron P., additional, Wong, Brian M., additional, Hansen, Mark S., additional, Weinerman, Adina S., additional, Shadowitz, Steven, additional, Elman, Debra, additional, Farkouh, Michael E., additional, Thavendiranathan, Paaladinesh, additional, Udell, Jacob A., additional, Johri, Amer M., additional, Chow, Chi-Ming, additional, Hall, Judith, additional, Bouck, Zachary, additional, Cohen, Ashley, additional, Thorpe, Kevin E., additional, Rakowski, Harry, additional, Picard, Michael H., additional, and Weiner, Rory B., additional

Published
2017
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16. The Supply and Demand of the Cardiovascular Workforce

Author

Narang, Akhil, primary, Sinha, Shashank S., additional, Rajagopalan, Bharath, additional, Ijioma, Nkechinyere N., additional, Jayaram, Natalie, additional, Kithcart, Aaron P., additional, Tanguturi, Varsha K., additional, and Cullen, Michael W., additional

Published
2016
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19. Larger Than Life: A Unique Cause of Dyspnea in an Elderly Woman.

Author

Kithcart, Aaron P. and Beckman, Joshua A.

Subjects
*DYSPNEA, *RESPIRATORY diseases, *PULMONARY manifestations of general diseases, *AORTIC stenosis, *AORTIC valve diseases
Abstract

The article presents a case study on the causes of dyspnea in an elderly woman. It cites the case of an 89-year-old woman who was presented in a cardiology clinic due to recurrent shortness of breath and dyspnea on exertion. It also outlines the result of the patient's clinical examination that lead to her aortic stenosis diagnosis. It also mentions treatments received by the patient who has undergone transcatheter valve replacement (TAVR) and the complications recorded.

Published
2016
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28. Abstract 15628: Endothelial Cell RNAseq in Hypercholesterolemic Zebrafish Reveals Early Dynamic Changes in Neuromast-Enriched Genes

Author

Dai, Wei, Kithcart, Aaron P, Rainville, Nicholas, Deo, Rahul C, Beerens, Manu, and MacRae, Calum

Abstract

Introduction:The cellular and molecular phenotypes of atherosclerosis during development are largely unknown. Zebrafish has emerged as an appealing model to understand endothelial dysfunction during early atherogenesis, owing to their translucency enabling real-time imaging and large breeding capacity for high throughput screening. Furthermore, zebrafish share many of the same developmental pathways as humans, allowing the study of early vascular processes in a fully integrated vertebrate system.Methods:We fed larval zebrafish regular or high cholesterol diet (4%) for one week from 5 days post fertilization and isolated endothelial enriched compartments by fluorescent activated cell sorting using the endothelial cell marker FLK:GFP. We performed transcriptome profiling of sorted endothelial cells. We also examined endothelial morphological changes in high cholesterol-fed larval fish with live imaging.Results:In addition to the anticipated findings in lipid metabolism, we found an unexpected 4-10 fold enrichment of 16 neuromast-related genes in the endothelial-enriched compared to endothelial-depleted cell fractions. The expression of these neuromast-related genes is significantly down-regulated 3.1 +/- 0.5 fold by high cholesterol diet when compared with a control diet. These changes are not observed in unsorted samples or in controls. In association with these defects, there were highly reproducible abnormalities of vascular patterning with significantly increased branching indices estimated using a wide range of endpoints with Image J (p<0.01).Conclusions:We have identified a unique pathway abnormality in zebrafish rendered hypercholesterolemic during development that is associated with a series of genes implicated in mechanotransduction. We are currently exploring the mechanistic role of these genes in atherosclerosis biology. These insights into the earliest phases of dyslipidemic vascular biology will inform our understanding of the longitudinal pathogenesis of human disease and also form the basis for high throughput screens to reverse disease mechanisms.

Published
2019
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29. An Automated System for Categorizing Transthoracic Echocardiography Indications According to the Echocardiography Appropriate Use Criteria.

Author

Eisman AS, Weiner RB, Chen ES, Stey PC, Wadhera RK, Kithcart AP, and Sarkar IN

Subjects
Databases, Factual, Echocardiography economics, Echocardiography standards, Guideline Adherence, Heart diagnostic imaging, Humans, Machine Learning, Medical Records, Medicare, Radiology Information Systems, Reference Standards, Software, United States, Algorithms, Echocardiography classification, Practice Guidelines as Topic
Abstract

The Echocardiography Appropriate Use Criteria (EAUC) are a set of indications for transthoracic echocardiography (TTE) developed to guide physician decision making around ordering of TTE. In this study, an automated rule-based method for processing "indications" listed within TTE reports and classification into one of the major EAUC categories was developed and validated against a clinician-annotated reference standard. The system performed at a comparable level to trained physicians allowing for the automated classification of more than 30,000 TTE indications from a public database in less than ten minutes. The most common indication for TTE was Valvular assessment closely followed by General. Hypertension/Heart Failure/Cardiomyopathy, Acute, and Cardiac Structure assessment each contributed more than ten percent within this patient population. These results suggest potential for automated approaches for tracking appropriate use of TTE, as well as guide the development of systems for prospectively identifying when TTE use is recommended.

Published
2018

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