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153 results on '"Kitay-Cohen, Yona"'

17. Mortality prediction using a modified R2CHA2DS2-VASc score among hospitalized COVID-19 patients.

Author

Levy, David, Gur, Efrat, Topaz, Guy, Naser, Rawand, Kitay-Cohen, Yona, Benchetrit, Sydney, Sarel, Erez, Cohen-Hagai, Keren, and Wand, Ori

Abstract

The CHA2DS2-VASc score incorporates several comorbidities which have prognostic implications in COVID-19. We assessed whether a modified score (M-R2CHA2DS2-VASc), which includes pre-admission kidney function and male sex, could be used to classify mortality risk among people hospitalized with COVID-19. This retrospective study included adults admitted for COVID-19 between March and December 2020. Pre-admission glomerular filtration rate (GFR) was calculated based on serum creatinine and used for scoring M-R2CHA2DS2-VASc. Participants were categorized according to the M-R2CHA2DS2-VASc categories as 0–1 (low), 2–3 (intermediate), or ≥ 4 (high), and according to initial COVID-19 severity score. The primary outcome was 30-day mortality rates. Secondary outcomes were mortality rates over time, and rates of mechanical ventilation, hemodynamic support, and renal replacement therapy. Eight hundred hospitalizations met the study criteria. Participants were 55% males, average age was 65.2 ± 17 years. There were similar proportions of subjects across the M-R2CHA2DS2-VASc categories. 30-day mortality was higher in those in higher M-R2CHA2DS2-VASc category and with severe or critical COVID-19 at admission. Subjects in the low, intermediate, and high M-R2CHA2DS2-VASc categories had 30-day mortality rates of 4.7%, 17% and 31%, respectively (p < 0.001). Higher category was also associated with increased need for mechanical ventilation and renal replacement therapy. All-cause 90-day mortality remained significantly associated with M-R2CHA2DS2-VASc. The M-R2CHA2DS2-VASc score is associated with 30-day mortality rates among patients hospitalized with COVID-19, and adds predictive value when combined with initial COVID-19 severity. [ABSTRACT FROM AUTHOR]

Published
2022
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23. The association between red cell distribution width and clinical outcomes in patients hospitalised due to chest pain

Author

Topaz, Guy, Yeruchimovich, Michael, Pereg, David, Eitan, Mayan, Kitay-Cohen, Yona, Hammer, Yoav, Zadok, Osnat Itzhaki Ben, and Eisen, Alon

Abstract

Background: Red blood cell distribution width (RDW) is a measure of the degree of heterogeneity of erythrocyte volume. Higher RDW levels are associated with increased mortality among patients with acute coronary syndrome (ACS), heart failure and other cardiovascular diseases. The association between RDW levels and clinical outcomes in patients admitted for further evaluation of chest pain is not known. Methods: A retrospective analysis of patients hospitalised with chest pain 2010–2016 was conducted. Patients diagnosed with ACS in the emergency department (ED) were excluded. Patients were divided into tertiles according to baseline ED RDW levels (≤13.1%, 13.1%13.9%). Study endpoints were diagnosis of ACS during the index hospitalisation and ACS and all-cause mortality during a median follow-up of 3.3 ± 1.9 years. Results: Included were 13,018 patients (mean age 58 ± 13 years, 61% male). Increased RDW levels were associated with higher rates of ACS in the index hospitalisation (6.1%, 6.6% and 8.1% for 1st, 2nd and 3rd tertiles, respectively, p < .01), ACS during follow-up (8.6%, 10.1% and 13.4%, respectively, p < .01), and with all-cause mortality during follow-up (2.5%, 4.6% and 15.4%, respectively, p < .01). In multivariate analysis, RDW levels >13.9% (vs. ≤13.1%) were associated with ACS in the index hospitalisation (adjusted OR 1.25, 95% CI 1.04–1.51, p = .02), ACS during follow-up (adjusted OR 1.35, 95% CI 1.05–1.73, p = .02) and with all-cause mortality (adjusted HR 2.41, 95% CI 1.94–2.99, p < .01). Conclusion: In this retrospective study of patients hospitalised with chest pain, higher RDW levels were associated with future ACS and long-term mortality.

Published
2019
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30. HCV Genotype-1 Subtypes and Resistance-Associated Substitutions in Drug-Naive and in Direct-Acting Antiviral Treatment Failure Patients

Author

Gozlan, Yael, primary, Ben-Ari, Ziv, additional, Moscona, Roy, additional, Shirazi, Rachel, additional, Rakovsky, Aviya, additional, Kabat, Arij, additional, Veizman, Ella, additional, Berdichevski, Tania, additional, Weiss, Peretz, additional, Cohen-Ezra, Oranit, additional, Lurie, Yoav, additional, Gafanovich, Inna, additional, Braun, Marius, additional, Cohen-Naftaly, Michal, additional, Shlomai, Amir, additional, Shibolet, Oren, additional, Zigmond, Ehud, additional, Zuckerman, Eli, additional, Carmiel-Haggai, Michal, additional, Nimer, Assy, additional, Hazzan, Rawi, additional, Maor, Yaakov, additional, Kitay-Cohen, Yona, additional, Shemer-Avni, Yonat, additional, Kra-Oz, Zipi, additional, Schreiber, Licita, additional, Peleg, Ofer, additional, Sierra, Saleta, additional, Harrigan, P Richard, additional, Mendelson, Ella, additional, and Mor, Orna, additional

Published
2016
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36. Telomere Dysfunction in Nonalcoholic Fatty Liver Disease and Cryptogenic Cirrhosis.

Author

Laish, Ido, Mannasse-Green, Batya, Hadary, Ruth, Biron-Shental, Tal, Konikoff, Fred M., amiel, aliza, and Kitay-Cohen, Yona

Subjects
FATTY liver, THERAPEUTICS, CANCER risk factors, LIVER cancer, CIRRHOSIS of the liver, GENE expression, GENETICS
Abstract

Nonalcoholic fatty liver disease (NAFLD) and cryptogenic cirrhosis (CC) are considered preneoplastic conditions that might progress to hepatocellular carcinoma. We evaluated parameters of telomere dysfunction in these patient groups to study the correlation between telomere length and the progression of NAFLD. We analyzed peripheral lymphocytes from 22 patients with NAFLD, 20 patients with CC, and 20 healthy, age-matched controls. Telomere length was analyzed using quantitative fluorescence in situ hybridization, and cellular senescence was evaluated by the percentage of cells with senescence-associated heterochromatin foci. The expression of telomerase reverse transcriptase (hTERT) mRNA was measured using polymerase chain reaction, and telomere capture (TC) was assessed with 2 Cytocell probes, 15qter and 13qter. Shorter telomere length and increased cellular senescence was demonstrated in patients with NAFLD, compared to the CC patients and healthy controls. While hTERT mRNA was significantly decreased, TC was increased in CC patients, compared to the NAFLD group and healthy individuals. Thus, there is a correlation between hTERT mRNA expression and telomere length in patients with NAFLD, which might be related to associated metabolic disorders and the risk of malignant transformation. Patients with CC, on the contrary, elongate their telomeres through the TC mechanism. [ABSTRACT FROM AUTHOR]

Published
2017
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39. HCV Genotype-1 Subtypes and Resistance-Associated Substitutions in Drug-Naive and in Direct-Acting Antiviral Treatment Failure Patients

Author

Gozlan, Yael, Ben-Ari, Ziv, Moscona, Roy, Shirazi, Rachel, Rakovsky, Aviya, Kabat, Arij, Veizman, Ella, Berdichevski, Tania, Weiss, Peretz, Cohen-Ezra, Oranit, Lurie, Yoav, Gafanovich, Inna, Braun, Marius, Cohen-Naftaly, Michal, Shlomai, Amir, Shibolet, Oren, Zigmond, Ehud, Zuckerman, Eli, Carmiel-Haggai, Michal, Nimer, Assy, Hazzan, Rawi, Maor, Yaakov, Kitay-Cohen, Yona, Shemer-Avni, Yonat, Kra-Oz, Zipi, Schreiber, Licita, Peleg, Ofer, Sierra, Saleta, Harrigan, P Richard, Mendelson, Ella, and Mor, Orna

Abstract

Background Direct-acting antiviral (DAA) treatment regimens and response rates of patients with HCV genotype-1 (GT1) are currently considered subtype-dependent. Identification of clinically relevant resistance-associated substitutions (RASs) in the NS3 and NS5A proteins at baseline and in DAA failures, may also impact clinical decisions.Methods In a multicentre cohort study (n=308), NS3 or NS5B sequencing (n=248) was used to discriminate between GT1 subtypes. The correlation between baseline NS3 and NS5A RASs on the 12-week sustained virological response (SVR12) rates of 160 of the patients treated with second-generation DAAs was also assessed. Post-treatment resistance analysis was performed on samples from 58 patients exhibiting DAA virological failure.Results GT1a, GT1b and GT1d subtypes were identified in 23.0%, 75.4% and 1.2% of tested samples. GT1b was most prevalent (97.7%, 128/131) among patients born in the former Soviet Union. The Q80K NS3 RAS was identified in 17.5% (10/57) of the GT1a carriers, most of whom were Israeli-born. NS3 and NS5A baseline RASs showed a negligible correlation with SVR12 rates. Treatment-emergent RASs were observed among 8.9% (4/45) and 76.9% (10/13) of first- and second-generation DAA failures, respectively, with D168V/E (NS3), Y93H and L31M (NS5A) being the most prevalent mutations.Conclusions NS3 sequencing analysis can successfully discriminate between GT1 subtypes and identify NS3 amino acid substitutions. While pre-treatment NS3 and NS5A RASs marginally affect second-generation DAA SVR12 rates, post-treatment resistance analysis should be considered prior to re-therapy.

Published
2017
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40. Pauci-immune Crescentic Glomerulonephritis in a Patient With Immunoglobulin A Nephropathy and Serum Antineutrophil Cytoplasmic Autoantibody Positivity.

Author

COHEN-HAGAI, Keren, BENCHETRIT, Sydney, KLEIN, Osnat, KITAY-COHEN, Yona, and KORZETS, Ze'ev

Subjects
HEMATURIA diagnosis, PROTEINURIA diagnosis, BIOPSY, CREATININE, ENZYME-linked immunosorbent assay, FLUORESCENT antibody technique, GLOMERULAR filtration rate, GLOMERULONEPHRITIS, IMMUNOGLOBULINS, OXIDOREDUCTASES, STAINS & staining (Microscopy), STEROIDS, URINALYSIS, VASCULITIS, CYCLOPHOSPHAMIDE, ANTINEUTROPHIL cytoplasmic antibodies, BLOOD, DIAGNOSIS
Published
2018
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48. Immediate and Prolonged Effects of Drugs on Rhythm's Characteristics:Relevance to Chronochemotherapy.

Author

Ashkenazi1,, Israel I.E., Carlebach, Rachel R., Kitay-Cohen, Yona Y., Zvulunov, Alexander A., and Peleg, Leah L.

Subjects
BIOLOGICAL rhythms, DRUG therapy, MICE, CHRONOBIOLOGY
Abstract

Four groups of mice were injected with vincristine each at a different time, for ten successive days. Mortality and daily pattern of peripheral white blood cells (WBC) count were monitored immediately and at various times after the last injection. The results demonstrated that (1) drug administration time dependency was observed in rate of death, recorded for 80 days following the injections; (2) the time of drug administration affected the parameters of WBC count rhythm, and (3) there were differences between immediate effects upon the rhythm parameters (monitored one day after the last injection) to those measured at succeeding times (on days 8 and 15 after injections cessation). The results emphasize the need to consider continuous post administration rhythm changes, especially when scheduling repeated chronotherapeutics, where variables which serve for toxicity-diagnosis are rhythmic in nature. [ABSTRACT FROM AUTHOR]

Published
1998
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49. Thyrotoxic Hepatitis.

Author

Barzilay-Yoseph, Liat, Shabun, Alia, Shilo, Lotan, Hadary, Ruth, Nabriski, Dan, and Kitay-Cohen, Yona

Published
2011

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