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2. Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

Author

Kitajima, Shunsuke, Asahina, Hajime, Chen, Ting, Guo, Sujuan, Quiceno, Laura Gutierrez, Cavanaugh, Jillian D, Merlino, Ashley A, Tange, Shoichiro, Terai, Hideki, Kim, Jong Wook, Wang, Xiaoen, Zhou, Shan, Xu, Man, Wang, Stephen, Zhu, Zehua, Thai, Tran C, Takahashi, Chiaki, Wang, Yujin, Neve, Richard, Stinson, Susanna, Tamayo, Pablo, Watanabe, Hideo, Kirschmeier, Paul T, Wong, Kwok-Kin, and Barbie, David A

Subjects
Cancer, Lung, Lung Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, AMP-Activated Protein Kinase Kinases, AMP-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Animals, Antineoplastic Agents, Immunological, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Disease Models, Animal, Drug Resistance, Neoplasm, HEK293 Cells, Humans, Immunity, Innate, Insulin-Like Growth Factor I, Lung Neoplasms, Mice, Mice, Transgenic, Mitogen-Activated Protein Kinase Kinases, Phosphoproteins, Protein Kinase Inhibitors, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins p21(ras), Transcription Factors, YAP-Signaling Proteins, BET inhibitor, IL-6, KRAS, MEK inhibitor, STK11/LKB1, TBK1 inhibitor, TP53, YAP1 signaling, innate immune signaling, non-small-cell lung cancer, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Despite extensive efforts, oncogenic KRAS remains resistant to targeted therapy. Combined downstream RAL-TBK1 and MEK inhibition induces only transient lung tumor shrinkage in KRAS-driven genetically engineered mouse models (GEMMs). Using the sensitive KRAS;LKB1 (KL) mutant background, we identify YAP1 upregulation and a therapy-induced secretome as mediators of acquired resistance. This program is reversible, associated with H3K27 promoter acetylation, and suppressed by BET inhibition, resensitizing resistant KL cells to TBK1/MEK inhibition. Constitutive YAP1 signaling promotes intrinsic resistance in KRAS;TP53 (KP) mutant lung cancer. Intermittent treatment with the BET inhibitor JQ1 thus overcomes resistance to combined pathway inhibition in KL and KP GEMMs. Using potent and selective TBK1 and BET inhibitors we further develop an effective therapeutic strategy with potential translatability to the clinic.

Published
2018

3. Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses

Author

Cañadas, Israel, Thummalapalli, Rohit, Kim, Jong Wook, Kitajima, Shunsuke, Jenkins, Russell William, Christensen, Camilla Laulund, Campisi, Marco, Kuang, Yanan, Zhang, Yanxi, Gjini, Evisa, Zhang, Gao, Tian, Tian, Sen, Debattama Rai, Miao, Diana, Imamura, Yu, Thai, Tran, Piel, Brandon, Terai, Hideki, Aref, Amir Reza, Hagan, Timothy, Koyama, Shohei, Watanabe, Masayuki, Baba, Hideo, Adeni, Anika Elise, Lydon, Christine Anne, Tamayo, Pablo, Wei, Zhi, Herlyn, Meenhard, Barbie, Thanh Uyen, Uppaluri, Ravindra, Sholl, Lynnette Marie, Sicinska, Ewa, Sands, Jacob, Rodig, Scott, Wong, Kwok Kin, Paweletz, Cloud Peter, Watanabe, Hideo, and Barbie, David Allen

Subjects
Genetics, Cancer, Vaccine Related, Immunization, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Animals, Cell Line, Tumor, Endogenous Retroviruses, Gene Expression Regulation, Neoplastic, Humans, Immunity, Innate, Interferons, Mice, Nude, Neoplasms, RNA, Antisense, Medical and Health Sciences, Immunology
Abstract

Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs) that engages innate immune signaling in these cells. Stimulated 3 prime antisense retroviral coding sequences (SPARCS) are oriented inversely in 3' untranslated regions of specific genes enriched for regulation by STAT1 and EZH2. Derepression of these loci results in double-stranded RNA generation following IFN-γ exposure due to bi-directional transcription from the STAT1-activated gene promoter and the 5' long terminal repeat of the antisense ERV. Engagement of MAVS and STING activates downstream TBK1, IRF3, and STAT1 signaling, sustaining a positive feedback loop. SPARCS induction in human tumors is tightly associated with major histocompatibility complex class 1 expression, mesenchymal markers, and downregulation of chromatin modifying enzymes, including EZH2. Analysis of cell lines with high inducible SPARCS expression reveals strong association with an AXL/MET-positive mesenchymal cell state. While SPARCS-high tumors are immune infiltrated, they also exhibit multiple features of an immune-suppressed microenviroment. Together, these data unveil a subclass of ERVs whose derepression triggers pathologic innate immune signaling in cancer, with important implications for cancer immunotherapy.

Published
2018

4. Supplementary figure S4 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Author

Tani, Tetsuo, primary, Mathsyaraja, Haritha, primary, Campisi, Marco, primary, Li, Ze-Hua, primary, Haratani, Koji, primary, Fahey, Caroline G., primary, Ota, Keiichi, primary, Mahadevan, Navin R., primary, Shi, Yingxiao, primary, Saito, Shin, primary, Mizuno, Kei, primary, Thai, Tran C., primary, Sasaki, Nobunari, primary, Homme, Mizuki, primary, Yusuf, Choudhury Fabliha B., primary, Kashishian, Adam, primary, Panchal, Jipsa, primary, Wang, Min, primary, Wolf, Benjamin J., primary, Barbie, Thanh U., primary, Paweletz, Cloud P., primary, Gokhale, Prafulla C., primary, Liu, David, primary, Uppaluri, Ravindra, primary, Kitajima, Shunsuke, primary, Cain, Jennifer, primary, and Barbie, David A., primary

Published
2024
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5. Data from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Author

Tani, Tetsuo, primary, Mathsyaraja, Haritha, primary, Campisi, Marco, primary, Li, Ze-Hua, primary, Haratani, Koji, primary, Fahey, Caroline G., primary, Ota, Keiichi, primary, Mahadevan, Navin R., primary, Shi, Yingxiao, primary, Saito, Shin, primary, Mizuno, Kei, primary, Thai, Tran C., primary, Sasaki, Nobunari, primary, Homme, Mizuki, primary, Yusuf, Choudhury Fabliha B., primary, Kashishian, Adam, primary, Panchal, Jipsa, primary, Wang, Min, primary, Wolf, Benjamin J., primary, Barbie, Thanh U., primary, Paweletz, Cloud P., primary, Gokhale, Prafulla C., primary, Liu, David, primary, Uppaluri, Ravindra, primary, Kitajima, Shunsuke, primary, Cain, Jennifer, primary, and Barbie, David A., primary

Published
2024
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6. Supplementary Table S1 from TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Author

Tani, Tetsuo, primary, Mathsyaraja, Haritha, primary, Campisi, Marco, primary, Li, Ze-Hua, primary, Haratani, Koji, primary, Fahey, Caroline G., primary, Ota, Keiichi, primary, Mahadevan, Navin R., primary, Shi, Yingxiao, primary, Saito, Shin, primary, Mizuno, Kei, primary, Thai, Tran C., primary, Sasaki, Nobunari, primary, Homme, Mizuki, primary, Yusuf, Choudhury Fabliha B., primary, Kashishian, Adam, primary, Panchal, Jipsa, primary, Wang, Min, primary, Wolf, Benjamin J., primary, Barbie, Thanh U., primary, Paweletz, Cloud P., primary, Gokhale, Prafulla C., primary, Liu, David, primary, Uppaluri, Ravindra, primary, Kitajima, Shunsuke, primary, Cain, Jennifer, primary, and Barbie, David A., primary

Published
2024
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7. Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States

Author

Kim, Jong Wook, Abudayyeh, Omar O, Yeerna, Huwate, Yeang, Chen-Hsiang, Stewart, Michelle, Jenkins, Russell W, Kitajima, Shunsuke, Konieczkowski, David J, Medetgul-Ernar, Kate, Cavazos, Taylor, Mah, Clarence, Ting, Stephanie, Van Allen, Eliezer M, Cohen, Ofir, Mcdermott, John, Damato, Emily, Aguirre, Andrew J, Liang, Jonathan, Liberzon, Arthur, Alexe, Gabriella, Doench, John, Ghandi, Mahmoud, Vazquez, Francisca, Weir, Barbara A, Tsherniak, Aviad, Subramanian, Aravind, Meneses-Cime, Karina, Park, Jason, Clemons, Paul, Garraway, Levi A, Thomas, David, Boehm, Jesse S, Barbie, David A, Hahn, William C, Mesirov, Jill P, and Tamayo, Pablo

Subjects
Biological Sciences, Genetics, Biotechnology, Human Genome, Cancer, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Biomarkers, Tumor, Cell Line, Tumor, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, ras, Genome, Humans, MAP Kinase Signaling System, Neoplasms, Precision Medicine, Bayesian nomogram, cellular states, drug sensitivity, genetic dependency, inferential model, matrix factorization, oncoGPS, oncogenic pathway, precision medicine, transcriptional signatures, Biochemistry and Cell Biology, Biochemistry and cell biology
Abstract

The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies. Here, we describe Onco-GPS (OncoGenic Positioning System), a data-driven analysis framework to organize individual tumor samples with shared oncogenic alterations onto a reference map defined by their underlying cellular states. We applied the methodology to the RAS pathway and identified nine distinct components that reflect transcriptional activities downstream of RAS and defined several functional states associated with patterns of transcriptional component activation that associates with genomic hallmarks and response to genetic and pharmacological perturbations. These results show that the Onco-GPS is an effective approach to explore the complex landscape of oncogenic cellular states across cancers, and an analytic framework to summarize knowledge, establish relationships, and generate more effective disease models for research or as part of individualized precision medicine paradigms.

Published
2017

8. TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

Author

Tani, Tetsuo, primary, Mathsyaraja, Haritha, additional, Campisi, Marco, additional, Li, Ze-Hua, additional, Haratani, Koji, additional, Fahey, Caroline G., additional, Ota, Keiichi, additional, Mahadevan, Navin R., additional, Shi, Yingxiao, additional, Saito, Shin, additional, Mizuno, Kei, additional, Thai, Tran C., additional, Sasaki, Nobunari, additional, Homme, Mizuki, additional, Yusuf, Choudhury Fabliha B., additional, Kashishian, Adam, additional, Panchal, Jipsa, additional, Wang, Min, additional, Wolf, Benjamin J., additional, Barbie, Thanh U., additional, Paweletz, Cloud P., additional, Gokhale, Prafulla C., additional, Liu, David, additional, Uppaluri, Ravindra, additional, Kitajima, Shunsuke, additional, Cain, Jennifer, additional, and Barbie, David A., additional

Published
2024
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9. STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, Akbay, Esra A, Li, Yvonne Y, Aref, Amir R, Skoulidis, Ferdinandos, Herter-Sprie, Grit S, Buczkowski, Kevin A, Liu, Yan, Awad, Mark M, Denning, Warren L, Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R, Wistuba, Ignacio I, Soucheray, Margaret, Thai, Tran, Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D, Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E, Shimamura, Takeshi, Hellmann, Matthew D, Heymach, John V, Hodi, F Stephen, Freeman, Gordon J, Barbie, David A, Dranoff, Glenn, Hammerman, Peter S, and Wong, Kwok-Kin

Subjects
Clinical Research, Lung, Cancer, Lung Cancer, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Aetiology, Development of treatments and therapeutic interventions, AMP-Activated Protein Kinase Kinases, AMP-Activated Protein Kinases, Animals, B7-H1 Antigen, Cytokines, Humans, Lung Neoplasms, Lymphocytes, Tumor-Infiltrating, Mice, Mutation, Neutrophil Infiltration, Protein Serine-Threonine Kinases, T-Lymphocytes, Tumor Microenvironment, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes promote immune escape, undermining the effectiveness of immunotherapies, but it is unclear whether the inactivation of tumor suppressor genes, such as STK11/LKB1, exerts similar effects. In this study, we investigated the consequences of STK11/LKB1 loss on the immune microenvironment in a mouse model of KRAS-driven NSCLC. Genetic ablation of STK11/LKB1 resulted in accumulation of neutrophils with T-cell-suppressive effects, along with a corresponding increase in the expression of T-cell exhaustion markers and tumor-promoting cytokines. The number of tumor-infiltrating lymphocytes was also reduced in LKB1-deficient mouse and human tumors. Furthermore, STK11/LKB1-inactivating mutations were associated with reduced expression of PD-1 ligand PD-L1 in mouse and patient tumors as well as in tumor-derived cell lines. Consistent with these results, PD-1-targeting antibodies were ineffective against Lkb1-deficient tumors. In contrast, treating Lkb1-deficient mice with an IL6-neutralizing antibody or a neutrophil-depleting antibody yielded therapeutic benefits associated with reduced neutrophil accumulation and proinflammatory cytokine expression. Our findings illustrate how tumor suppressor mutations can modulate the immune milieu of the tumor microenvironment, and they offer specific implications for addressing STK11/LKB1-mutated tumors with PD-1-targeting antibody therapies.

Published
2016

11. Abstract 1706: A non-canonical MiT/TFE-dependent NRF2 program is a druggable vulnerability in multiple cancer types

Author

Luo, Xinbo, primary, Lutterbach, Bart, additional, Pancholi, Priya, additional, Choi, Yeon Sook, additional, Liu, Xiao, additional, Munson, Phillip, additional, Faisal, Saqib, additional, Whipple, David A., additional, Smith, Robert A., additional, Weiner, Warren S., additional, Johnson, David K., additional, Boukhali, Myriam, additional, Persky, Nicole S., additional, Rees, Matthew G., additional, Kitajima, Shunsuke, additional, Barbie, David, additional, Roy, Anuradha, additional, Baltezor, Michael, additional, Rajewski, Lian, additional, McGuinness, William, additional, Haslam, John, additional, Sadagopan, Ananthan, additional, Yoon, Charles H., additional, Johannessen, Cory M., additional, Lian, Christine G., additional, Hornick, Jason L., additional, Viswanathan, Srinivas R., additional, Liu, David, additional, Nienaber, Vicki, additional, Haas, Wilhelm, additional, Schoenen, Frank J., additional, Fisher, David E., additional, and Haq, Rizwan, additional

Published
2023
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12. Data from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
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13. Data from Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity

Author

Mahadevan, Navin R., primary, Knelson, Erik H., primary, Wolff, Jacquelyn O., primary, Vajdi, Amir, primary, Saigí, Maria, primary, Campisi, Marco, primary, Hong, Deli, primary, Thai, Tran C., primary, Piel, Brandon, primary, Han, Saemi, primary, Reinhold, Bruce B., primary, Duke-Cohan, Jonathan S., primary, Poitras, Michael J., primary, Taus, Luke J., primary, Lizotte, Patrick H., primary, Portell, Andrew, primary, Quadros, Victor, primary, Santucci, Alison D., primary, Murayama, Takahiko, primary, Cañadas, Israel, primary, Kitajima, Shunsuke, primary, Akitsu, Aoi, primary, Fridrikh, Maya, primary, Watanabe, Hideo, primary, Reardon, Brendan, primary, Gokhale, Prafulla C., primary, Paweletz, Cloud P., primary, Awad, Mark M., primary, Van Allen, Eliezer M., primary, Lako, Ana, primary, Wang, Xi-Tao, primary, Chen, Benjamin, primary, Hong, Fangxin, primary, Sholl, Lynette M., primary, Tolstorukov, Michael Y., primary, Pfaff, Kathleen, primary, Jänne, Pasi A., primary, Gjini, Evisa, primary, Edwards, Robin, primary, Rodig, Scott, primary, Reinherz, Ellis L., primary, Oser, Matthew G., primary, and Barbie, David A., primary

Published
2023
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14. Supplementary Table S3 from Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity

Author

Mahadevan, Navin R., primary, Knelson, Erik H., primary, Wolff, Jacquelyn O., primary, Vajdi, Amir, primary, Saigí, Maria, primary, Campisi, Marco, primary, Hong, Deli, primary, Thai, Tran C., primary, Piel, Brandon, primary, Han, Saemi, primary, Reinhold, Bruce B., primary, Duke-Cohan, Jonathan S., primary, Poitras, Michael J., primary, Taus, Luke J., primary, Lizotte, Patrick H., primary, Portell, Andrew, primary, Quadros, Victor, primary, Santucci, Alison D., primary, Murayama, Takahiko, primary, Cañadas, Israel, primary, Kitajima, Shunsuke, primary, Akitsu, Aoi, primary, Fridrikh, Maya, primary, Watanabe, Hideo, primary, Reardon, Brendan, primary, Gokhale, Prafulla C., primary, Paweletz, Cloud P., primary, Awad, Mark M., primary, Van Allen, Eliezer M., primary, Lako, Ana, primary, Wang, Xi-Tao, primary, Chen, Benjamin, primary, Hong, Fangxin, primary, Sholl, Lynette M., primary, Tolstorukov, Michael Y., primary, Pfaff, Kathleen, primary, Jänne, Pasi A., primary, Gjini, Evisa, primary, Edwards, Robin, primary, Rodig, Scott, primary, Reinherz, Ellis L., primary, Oser, Matthew G., primary, and Barbie, David A., primary

Published
2023
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15. Data from Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

Author

Kitajima, Shunsuke, primary, Ivanova, Elena, primary, Guo, Sujuan, primary, Yoshida, Ryohei, primary, Campisi, Marco, primary, Sundararaman, Shriram K., primary, Tange, Shoichiro, primary, Mitsuishi, Yoichiro, primary, Thai, Tran C., primary, Masuda, Sayuri, primary, Piel, Brandon P., primary, Sholl, Lynette M., primary, Kirschmeier, Paul T., primary, Paweletz, Cloud P., primary, Watanabe, Hideo, primary, Yajima, Mamiko, primary, and Barbie, David A., primary

Published
2023
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16. Supp. Movie 3 from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
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17. Supp. Movie 1 from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
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18. Table S3 from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
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19. Supplementary Figures 1 through 8 from Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

Author

Yang, Shenghong, primary, Imamura, Yu, primary, Jenkins, Russell W., primary, Cañadas, Israel, primary, Kitajima, Shunsuke, primary, Aref, Amir, primary, Brannon, Arthur, primary, Oki, Eiji, primary, Castoreno, Adam, primary, Zhu, Zehua, primary, Thai, Tran, primary, Reibel, Jacob, primary, Qian, Zhirong, primary, Ogino, Shuji, primary, Wong, Kwok K., primary, Baba, Hideo, primary, Kimmelman, Alec C., primary, Pasca Di Magliano, Marina, primary, and Barbie, David A., primary

Published
2023
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20. Supplementary Figures 1-12 from Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity

Author

Mahadevan, Navin R., primary, Knelson, Erik H., primary, Wolff, Jacquelyn O., primary, Vajdi, Amir, primary, Saigí, Maria, primary, Campisi, Marco, primary, Hong, Deli, primary, Thai, Tran C., primary, Piel, Brandon, primary, Han, Saemi, primary, Reinhold, Bruce B., primary, Duke-Cohan, Jonathan S., primary, Poitras, Michael J., primary, Taus, Luke J., primary, Lizotte, Patrick H., primary, Portell, Andrew, primary, Quadros, Victor, primary, Santucci, Alison D., primary, Murayama, Takahiko, primary, Cañadas, Israel, primary, Kitajima, Shunsuke, primary, Akitsu, Aoi, primary, Fridrikh, Maya, primary, Watanabe, Hideo, primary, Reardon, Brendan, primary, Gokhale, Prafulla C., primary, Paweletz, Cloud P., primary, Awad, Mark M., primary, Van Allen, Eliezer M., primary, Lako, Ana, primary, Wang, Xi-Tao, primary, Chen, Benjamin, primary, Hong, Fangxin, primary, Sholl, Lynette M., primary, Tolstorukov, Michael Y., primary, Pfaff, Kathleen, primary, Jänne, Pasi A., primary, Gjini, Evisa, primary, Edwards, Robin, primary, Rodig, Scott, primary, Reinherz, Ellis L., primary, Oser, Matthew G., primary, and Barbie, David A., primary

Published
2023
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21. Table S3 from Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

Author

Kitajima, Shunsuke, primary, Ivanova, Elena, primary, Guo, Sujuan, primary, Yoshida, Ryohei, primary, Campisi, Marco, primary, Sundararaman, Shriram K., primary, Tange, Shoichiro, primary, Mitsuishi, Yoichiro, primary, Thai, Tran C., primary, Masuda, Sayuri, primary, Piel, Brandon P., primary, Sholl, Lynette M., primary, Kirschmeier, Paul T., primary, Paweletz, Cloud P., primary, Watanabe, Hideo, primary, Yajima, Mamiko, primary, and Barbie, David A., primary

Published
2023
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22. Supplementary Data from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
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25. Data from Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

Author

Yang, Shenghong, primary, Imamura, Yu, primary, Jenkins, Russell W., primary, Cañadas, Israel, primary, Kitajima, Shunsuke, primary, Aref, Amir, primary, Brannon, Arthur, primary, Oki, Eiji, primary, Castoreno, Adam, primary, Zhu, Zehua, primary, Thai, Tran, primary, Reibel, Jacob, primary, Qian, Zhirong, primary, Ogino, Shuji, primary, Wong, Kwok K., primary, Baba, Hideo, primary, Kimmelman, Alec C., primary, Pasca Di Magliano, Marina, primary, and Barbie, David A., primary

Published
2023
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26. Supplementary Figures and Table legends from Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

Author

Kitajima, Shunsuke, primary, Ivanova, Elena, primary, Guo, Sujuan, primary, Yoshida, Ryohei, primary, Campisi, Marco, primary, Sundararaman, Shriram K., primary, Tange, Shoichiro, primary, Mitsuishi, Yoichiro, primary, Thai, Tran C., primary, Masuda, Sayuri, primary, Piel, Brandon P., primary, Sholl, Lynette M., primary, Kirschmeier, Paul T., primary, Paweletz, Cloud P., primary, Watanabe, Hideo, primary, Yajima, Mamiko, primary, and Barbie, David A., primary

Published
2023
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27. Supp. Movie 2 from Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Author

Jenkins, Russell W., primary, Aref, Amir R., primary, Lizotte, Patrick H., primary, Ivanova, Elena, primary, Stinson, Susanna, primary, Zhou, Chensheng W., primary, Bowden, Michaela, primary, Deng, Jiehui, primary, Liu, Hongye, primary, Miao, Diana, primary, He, Meng Xiao, primary, Walker, William, primary, Zhang, Gao, primary, Tian, Tian, primary, Cheng, Chaoran, primary, Wei, Zhi, primary, Palakurthi, Sangeetha, primary, Bittinger, Mark, primary, Vitzthum, Hans, primary, Kim, Jong Wook, primary, Merlino, Ashley, primary, Quinn, Max, primary, Venkataramani, Chandrasekar, primary, Kaplan, Joshua A., primary, Portell, Andrew, primary, Gokhale, Prafulla C., primary, Phillips, Bart, primary, Smart, Alicia, primary, Rotem, Asaf, primary, Jones, Robert E., primary, Keogh, Lauren, primary, Anguiano, Maria, primary, Stapleton, Lance, primary, Jia, Zhiheng, primary, Barzily-Rokni, Michal, primary, Cañadas, Israel, primary, Thai, Tran C., primary, Hammond, Marc R., primary, Vlahos, Raven, primary, Wang, Eric S., primary, Zhang, Hua, primary, Li, Shuai, primary, Hanna, Glenn J., primary, Huang, Wei, primary, Hoang, Mai P., primary, Piris, Adriano, primary, Eliane, Jean-Pierre, primary, Stemmer-Rachamimov, Anat O., primary, Cameron, Lisa, primary, Su, Mei-Ju, primary, Shah, Parin, primary, Izar, Benjamin, primary, Thakuria, Manisha, primary, LeBoeuf, Nicole R., primary, Rabinowits, Guilherme, primary, Gunda, Viswanath, primary, Parangi, Sareh, primary, Cleary, James M., primary, Miller, Brian C., primary, Kitajima, Shunsuke, primary, Thummalapalli, Rohit, primary, Miao, Benchun, primary, Barbie, Thanh U., primary, Sivathanu, Vivek, primary, Wong, Joshua, primary, Richards, William G., primary, Bueno, Raphael, primary, Yoon, Charles H., primary, Miret, Juan, primary, Herlyn, Meenhard, primary, Garraway, Levi A., primary, Van Allen, Eliezer M., primary, Freeman, Gordon J., primary, Kirschmeier, Paul T., primary, Lorch, Jochen H., primary, Ott, Patrick A., primary, Hodi, F. Stephen, primary, Flaherty, Keith T., primary, Kamm, Roger D., primary, Boland, Genevieve M., primary, Wong, Kwok-Kin, primary, Dornan, David, primary, Paweletz, Cloud Peter, primary, and Barbie, David A., primary

Published
2023
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28. Supplementary Figures from Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Author

Li, Fengkai, primary, Kitajima, Shunsuke, primary, Kohno, Susumu, primary, Yoshida, Akiyo, primary, Tange, Shoichiro, primary, Sasaki, Soichiro, primary, Okada, Nobuhiro, primary, Nishimoto, Yuuki, primary, Muranaka, Hayato, primary, Nagatani, Naoko, primary, Suzuki, Misa, primary, Masuda, Sayuri, primary, Thai, Tran C., primary, Nishiuchi, Takumi, primary, Tanaka, Tomoaki, primary, Barbie, David A., primary, Mukaida, Naofumi, primary, and Takahashi, Chiaki, primary

Published
2023
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29. Supplementary Data from MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer

Author

Yoshida, Ryohei, primary, Saigi, Maria, primary, Tani, Tetsuo, primary, Springer, Benjamin F., primary, Shibata, Hirofumi, primary, Kitajima, Shunsuke, primary, Mahadevan, Navin R., primary, Campisi, Marco, primary, Kim, William, primary, Kobayashi, Yoshihisa, primary, Thai, Tran C., primary, Haratani, Koji, primary, Yamamoto, Yurie, primary, Sundararaman, Shriram K., primary, Knelson, Erik H., primary, Vajdi, Amir, primary, Canadas, Israel, primary, Uppaluri, Ravindra, primary, Paweletz, Cloud P., primary, Miret, Juan J., primary, Lizotte, Patrick H., primary, Gokhale, Prafulla C., primary, Jänne, Pasi A., primary, and Barbie, David A., primary

Published
2023
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30. Data from Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Author

Li, Fengkai, primary, Kitajima, Shunsuke, primary, Kohno, Susumu, primary, Yoshida, Akiyo, primary, Tange, Shoichiro, primary, Sasaki, Soichiro, primary, Okada, Nobuhiro, primary, Nishimoto, Yuuki, primary, Muranaka, Hayato, primary, Nagatani, Naoko, primary, Suzuki, Misa, primary, Masuda, Sayuri, primary, Thai, Tran C., primary, Nishiuchi, Takumi, primary, Tanaka, Tomoaki, primary, Barbie, David A., primary, Mukaida, Naofumi, primary, and Takahashi, Chiaki, primary

Published
2023
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31. Data from ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors

Author

Terai, Hideki, primary, Kitajima, Shunsuke, primary, Potter, Danielle S., primary, Matsui, Yusuke, primary, Quiceno, Laura Gutierrez, primary, Chen, Ting, primary, Kim, Tae-jung, primary, Rusan, Maria, primary, Thai, Tran C., primary, Piccioni, Federica, primary, Donovan, Katherine A., primary, Kwiatkowski, Nicholas, primary, Hinohara, Kunihiko, primary, Wei, Guo, primary, Gray, Nathanael S., primary, Fischer, Eric S., primary, Wong, Kwok-Kin, primary, Shimamura, Teppei, primary, Letai, Anthony, primary, Hammerman, Peter S., primary, and Barbie, David A., primary

Published
2023
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32. Supplementary Table 2 from Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Author

Li, Fengkai, primary, Kitajima, Shunsuke, primary, Kohno, Susumu, primary, Yoshida, Akiyo, primary, Tange, Shoichiro, primary, Sasaki, Soichiro, primary, Okada, Nobuhiro, primary, Nishimoto, Yuuki, primary, Muranaka, Hayato, primary, Nagatani, Naoko, primary, Suzuki, Misa, primary, Masuda, Sayuri, primary, Thai, Tran C., primary, Nishiuchi, Takumi, primary, Tanaka, Tomoaki, primary, Barbie, David A., primary, Mukaida, Naofumi, primary, and Takahashi, Chiaki, primary

Published
2023
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33. Supplementary Methods from ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors

Author

Terai, Hideki, primary, Kitajima, Shunsuke, primary, Potter, Danielle S., primary, Matsui, Yusuke, primary, Quiceno, Laura Gutierrez, primary, Chen, Ting, primary, Kim, Tae-jung, primary, Rusan, Maria, primary, Thai, Tran C., primary, Piccioni, Federica, primary, Donovan, Katherine A., primary, Kwiatkowski, Nicholas, primary, Hinohara, Kunihiko, primary, Wei, Guo, primary, Gray, Nathanael S., primary, Fischer, Eric S., primary, Wong, Kwok-Kin, primary, Shimamura, Teppei, primary, Letai, Anthony, primary, Hammerman, Peter S., primary, and Barbie, David A., primary

Published
2023
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34. Supplementary Table S1 from ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors

Author

Terai, Hideki, primary, Kitajima, Shunsuke, primary, Potter, Danielle S., primary, Matsui, Yusuke, primary, Quiceno, Laura Gutierrez, primary, Chen, Ting, primary, Kim, Tae-jung, primary, Rusan, Maria, primary, Thai, Tran C., primary, Piccioni, Federica, primary, Donovan, Katherine A., primary, Kwiatkowski, Nicholas, primary, Hinohara, Kunihiko, primary, Wei, Guo, primary, Gray, Nathanael S., primary, Fischer, Eric S., primary, Wong, Kwok-Kin, primary, Shimamura, Teppei, primary, Letai, Anthony, primary, Hammerman, Peter S., primary, and Barbie, David A., primary

Published
2023
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35. Supplementary Table 1 from Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Author

Li, Fengkai, primary, Kitajima, Shunsuke, primary, Kohno, Susumu, primary, Yoshida, Akiyo, primary, Tange, Shoichiro, primary, Sasaki, Soichiro, primary, Okada, Nobuhiro, primary, Nishimoto, Yuuki, primary, Muranaka, Hayato, primary, Nagatani, Naoko, primary, Suzuki, Misa, primary, Masuda, Sayuri, primary, Thai, Tran C., primary, Nishiuchi, Takumi, primary, Tanaka, Tomoaki, primary, Barbie, David A., primary, Mukaida, Naofumi, primary, and Takahashi, Chiaki, primary

Published
2023
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36. Supplementary Figure S1-S6 from ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors

Author

Terai, Hideki, primary, Kitajima, Shunsuke, primary, Potter, Danielle S., primary, Matsui, Yusuke, primary, Quiceno, Laura Gutierrez, primary, Chen, Ting, primary, Kim, Tae-jung, primary, Rusan, Maria, primary, Thai, Tran C., primary, Piccioni, Federica, primary, Donovan, Katherine A., primary, Kwiatkowski, Nicholas, primary, Hinohara, Kunihiko, primary, Wei, Guo, primary, Gray, Nathanael S., primary, Fischer, Eric S., primary, Wong, Kwok-Kin, primary, Shimamura, Teppei, primary, Letai, Anthony, primary, Hammerman, Peter S., primary, and Barbie, David A., primary

Published
2023
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37. Supplementary methods from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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38. Supplementary method figure from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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39. Supplemental Figures from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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40. Supplementary figure legends from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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41. Data from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Author

Koyama, Shohei, primary, Akbay, Esra A., primary, Li, Yvonne Y., primary, Aref, Amir R., primary, Skoulidis, Ferdinandos, primary, Herter-Sprie, Grit S., primary, Buczkowski, Kevin A., primary, Liu, Yan, primary, Awad, Mark M., primary, Denning, Warren L., primary, Diao, Lixia, primary, Wang, Jing, primary, Parra-Cuentas, Edwin R., primary, Wistuba, Ignacio I., primary, Soucheray, Margaret, primary, Thai, Tran, primary, Asahina, Hajime, primary, Kitajima, Shunsuke, primary, Altabef, Abigail, primary, Cavanaugh, Jillian D., primary, Rhee, Kevin, primary, Gao, Peng, primary, Zhang, Haikuo, primary, Fecci, Peter E., primary, Shimamura, Takeshi, primary, Hellmann, Matthew D., primary, Heymach, John V., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Barbie, David A., primary, Dranoff, Glenn, primary, Hammerman, Peter S., primary, and Wong, Kwok-Kin, primary

Published
2023
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43. Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

Author

Sehgal, Kartik, Portell, Andrew, Ivanova, Elena V., Lizotte, Patrick H., Mahadevan, Navin R., Greene, Jonathan R., Vajdi, Amir, Gurjao, Carino, Teceno, Tyler, Taus, Luke J., Thai, Tran C., Kitajima, Shunsuke, Liu, Derek, Tani, Tetsuo, Noureddine, Moataz, Lau, Christie J., Kirschmeier, Paul T., Liu, David, Giannakis, Marios, Jenkins, Russell W., Gokhale, Prafulla C., Goldoni, Silvia, Pinzon-Ortiz, Maria, Hastings, William D., Hammerman, Peter S., Mire, Juan J., Paweletz, Cloud P., and Barbie, David A.

Subjects
Oncology, Experimental, RNA sequencing -- Usage, Carcinogenesis -- Research, Drug resistance -- Identification and classification, Immunotherapy -- Research, Cancer -- Care and treatment -- Research, Cancer cells -- Identification and classification, Health care industry
Abstract

Resistance to oncogene-targeted therapies involves discrete drug-tolerant persister cells, originally discovered through in vitro assays. Whether a similar phenomenon limits efficacy of programmed cell death 1 (PD-1) blockade is poorly understood. Here, we performed dynamic single-cell RNA-Seq of murine organotypic tumor spheroids undergoing PD-1 blockade, identifying a discrete subpopulation of immunotherapy persister cells (IPCs) that resisted CD[8.sup.+] T cell-mediated killing. These cells expressed Snai1 and stem cell antigen 1 (Sca-1) and exhibited hybrid epithelial-mesenchymal features characteristic of a stem cell-like state. IPCs were expanded by IL-6 but were vulnerable to TNF-[alpha]-induced cytotoxicity, relying on baculoviral IAP repeat-containing protein 2 (Birc2) and Birc3 as survival factors. Combining PD-1 blockade with Birc2/3 antagonism in mice reduced IPCs and enhanced tumor cell killing in vivo, resulting in durable responsiveness that matched TNF cytotoxicity thresholds in vitro. Together, these data demonstrate the power of high-resolution functional ex vivo profiling to uncover fundamental mechanisms of immune escape from durable anti-PD-1 responses, while identifying IPCs as a cancer cell subpopulation targetable by specific therapeutic combinations., Introduction Drug-tolerant persister cells (DTPCs) mediate resistance to oncogene-targeted cancer therapies by adopting a quiescent and apoptosis-resistant state (1-3). Analogous to the concept of 'antibiotic-tolerant' bacterial persister cells, these preexisting [...]

Published
2021
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44. MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

Author

Kitajima, Shunsuke, primary, Tani, Tetsuo, additional, Springer, Benjamin F., additional, Campisi, Marco, additional, Osaki, Tatsuya, additional, Haratani, Koji, additional, Chen, Minyue, additional, Knelson, Erik H., additional, Mahadevan, Navin R., additional, Ritter, Jessica, additional, Yoshida, Ryohei, additional, Köhler, Jens, additional, Ogino, Atsuko, additional, Nozawa, Ryu-Suke, additional, Sundararaman, Shriram K., additional, Thai, Tran C., additional, Homme, Mizuki, additional, Piel, Brandon, additional, Kivlehan, Sophie, additional, Obua, Bonje N., additional, Purcell, Connor, additional, Yajima, Mamiko, additional, Barbie, Thanh U., additional, Lizotte, Patrick H., additional, Jänne, Pasi A., additional, Paweletz, Cloud P., additional, Gokhale, Prafulla C., additional, and Barbie, David A., additional

Published
2022
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45. MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer

Author

Yoshida, Ryohei, primary, Saigi, Maria, additional, Tani, Tetsuo, additional, Springer, Benjamin F., additional, Shibata, Hirofumi, additional, Kitajima, Shunsuke, additional, Mahadevan, Navin R., additional, Campisi, Marco, additional, Kim, William, additional, Kobayashi, Yoshihisa, additional, Thai, Tran C., additional, Haratani, Koji, additional, Yamamoto, Yurie, additional, Sundararaman, Shriram K., additional, Knelson, Erik H., additional, Vajdi, Amir, additional, Canadas, Israel, additional, Uppaluri, Ravindra, additional, Paweletz, Cloud P., additional, Miret, Juan J., additional, Lizotte, Patrick H., additional, Gokhale, Prafulla C., additional, Jänne, Pasi A., additional, and Barbie, David A., additional

Published
2022
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46. KRAS G12C inhibition and innate immune targeting

Author

David A. Barbie, Kitajima Shunsuke, Tetsuo Tani, Erik H. Knelson, and Ella B Conway

Subjects
0301 basic medicine, Cell signaling, endocrine system diseases, Immune microenvironment, Clinical Biochemistry, Antineoplastic Agents, Biology, medicine.disease_cause, Article, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Drug Discovery, Tumor Microenvironment, medicine, Animals, Humans, Molecular Targeted Therapy, Immune Checkpoint Inhibitors, neoplasms, Pharmacology, Innate immune system, Oncogene, Cancer, medicine.disease, Immunity, Innate, digestive system diseases, respiratory tract diseases, Sting, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Mutation, Cancer research, Molecular Medicine, KRAS, Carcinogenesis
Abstract

INTRODUCTION: KRAS mutations drive tumorigenesis by altering cell signaling and the tumor immune microenvironment. Recent studies have shown promise for KRAS-G12C covalent inhibitors, which are advancing rapidly through clinical trials. The sequencing and combination of these agents with other therapies including immune checkpoint blockade (ICB) will benefit from strategies that also address the immune microenvironment to improve durability of response. AREAS COVERED: This paper reviews KRAS signaling and discusses downstream effects on cytokine production and the tumor immune microenvironment. RAS targeted therapy is introduced and perspectives on therapeutic targeting of KRAS-G12C and its immunosuppressive tumor microenvironment are offered. EXPERT OPINION: The availability of KRAS-G12C covalent inhibitors raises hopes for targeting this pervasive oncogene and designing better therapeutic combinations to promote anti-tumor immunity. A comprehensive mechanistic understanding of KRAS immunosuppression is required in order to prioritize agents for clinical trials.

Published
2021

47. The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

Author

Noyes, Christopher, primary, Kitajima, Shunsuke, additional, Li, Fengkai, additional, Suita, Yusuke, additional, Miriyala, Saradha, additional, Isaac, Shakson, additional, Ahsan, Nagib, additional, Knelson, Erik, additional, Vajdi, Amir, additional, Tani, Tetsuo, additional, Thai, Tran C., additional, Xu, Derek, additional, Murai, Junko, additional, Tapinos, Nikos, additional, Takahashi, Chiaki, additional, Barbie, David A., additional, and Yajima, Mamiko, additional

Published
2022
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49. Treatment of Retinoblastoma 1–Intact Hepatocellular Carcinoma With Cyclin‐Dependent Kinase 4/6 Inhibitor Combination Therapy

Author

Sheng, Jindan, primary, Kohno, Susumu, additional, Okada, Nobuhiro, additional, Okahashi, Nobuyuki, additional, Teranishi, Kana, additional, Matsuda, Fumio, additional, Shimizu, Hiroshi, additional, Linn, Paing, additional, Nagatani, Naoko, additional, Yamamura, Minako, additional, Harada, Kenichi, additional, Horike, Shin‐ichi, additional, Inoue, Hiroshi, additional, Yano, Seiji, additional, Kumar, Sharad, additional, Kitajima, Shunsuke, additional, Ajioka, Itsuki, additional, and Takahashi, Chiaki, additional

Published
2021
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