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1,022 results on '"Kitabatake, Akira"'

3. Cardiac Remodeling: Role of Neovascularization in Heart Failure

Author

Okamoto, Hiroshi, Watanabe, Masashi, Kumamoto, Hideki, Chiba, Satoru, Yoneya, Keiji, Onozuka, Hisao, Mikami, Taisei, Kawaguchi, Hideaki, Abe, Kazuhiro, Kitabatake, Akira, Kitabatake, Akira, editor, Sasayama, Shigetake, editor, Francis, Gary S., editor, and Okamoto, Hiroshi, editor

Published
2000
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5. S-Nitrosylated Polyethylene Glycol-conjugated Hemoglobin Derivative as a Candidate Material for Oxygen Therapeutics

Author

Nakai, Kunihiko, Sakuma, Ichiro, Togashi, Hiroko, Yoshioka, Mitsuhiro, Sugawara, Takeshi, Satoh, Hiroshi, Kitabatake, Akira, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Maeda, Hiroshi, editor, Kabanov, Alexander, editor, Kataoka, Kazunori, editor, and Okano, Teruo, editor

Published
2003
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23. Prevalence of atrial fibrillation in the general population of Japan: An analysis based on periodic health examination

Author

Inoue, Hiroshi, Fujiki, Akira, Origasa, Hideki, Ogawa, Satoshi, Okumura, Ken, Kubota, Isao, Aizawa, Yoshifusa, Yamashita, Takeshi, Atarashi, Hirotsugu, Horie, Minoru, Ohe, Tohru, Doi, Yoshinori, Shimizu, Akihiko, Chishaki, Akiko, Saikawa, Tetsunori, Yano, Katsusuke, Kitabatake, Akira, Mitamura, Hideo, Kodama, Itsuo, and Kamakura, Shiro

Published
2009
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24. Percutaneous Coronary Intervention Plus Medical Therapy Reduces the Incidence of Acute Coronary Syndrome More Effectively Than Initial Medical Therapy Only Among Patients With Low-Risk Coronary Artery Disease: A Randomized, Comparative, Multicenter Study

Author

Nishigaki, Kazuhiko, Yamazaki, Tsutomu, Kitabatake, Akira, Yamaguchi, Tetsu, Kanmatsuse, Katsuo, Kodama, Itsuo, Takekoshi, Noboru, Tomoike, Hitonobu, Hori, Masatsugu, Matsuzaki, Masunori, Takeshita, Akira, Shimbo, Takuro, and Fujiwara, Hisayoshi

Published
2008
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33. Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial

Author

Nakamura, Haruo, Arakawa, Kikuo, Itakura, Hiroshige, Kitabatake, Akira, Goto, Yoshio, Toyota, Takayoshi, Nakaya, Noriaki, Nishimoto, Shoji, Muranaka, Masaharu, Yamamoto, Akira, Mizuno, Kyoichi, and Ohashi, Yasuo

Subjects
Cardiovascular diseases -- Risk factors, Cardiovascular diseases -- Prevention, Pravastatin -- Health aspects, Hypercholesterolemia -- Drug therapy
Published
2006

43. Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts

Author

Morita, Noriteru, Iizuka, Kenji, Okita, Koichi, Oikawa, Takashi, Yonezawa, Kazuya, Nagai, Tatsuya, Tokumitsu, Yukiko, Murakami, Takeshi, Kitabatake, Akira, and Kawaguchi, Hideaki

Subjects
Muscles -- Research, Biological sciences
Abstract

Contraction of skeletal muscle generates pressure stimuli to intramuscular tissues. However, the effects of pressure stimuli, other than those created by electricity or nerve impulse, on physiological and biochemical responses in skeletal muscles are unknown. The purpose of this study is to examine the effects of a pure pressure stimulus on metabolic responses in a skeletal muscle cell line. Atmospheric pressure was applied to L6 myoblasts using an original apparatus. Succinate dehydrogenase (SDH) activity was evaluated by colorimetric assay using tetrazolium monosodium salt. The amounts of 2-deoxy-[[sup.3]H]glucose uptake and lactate release were measured. SDH activity was 2.6- to 2.9-fold higher in pressurized L6 ceils than in nonpressurized L6 cells (P < 0.01), and 2-deoxy-[[sup.3]H]glucose uptake was 2.2-fold higher (P < 0.001). In addition, the amount of released lactate decreased from 6.8 to 3.7 [micro]mol/dish when pressure was applied (P < 0.001). In contrast, the intracellular lactate contents of the pressurized cells were higher than those of nonpressurized cells (P < 0.01). However, the total amount of released lactate and intracellular lactate was lower in the pressurized cells than in nonpressurized cells. These findings demonstrate that a pure pressure stimulus enhances aerobic metabolism in L6 skeletal muscle cells and raise the possibility that elevated intramuscular pressure during muscle activity may be an important factor in stimulating oxidative metabolic responses in skeletal muscles. mechanical pressure; aerobic metabolism; lactate; glucose uptake

Published
2004

44. Low-dose carvedilol improves left ventricular function and reduces cardiovascular hospitalization in Japanese patients with chronic hear failure: The Multicenter Carvediolo Hear Failure Dose Assessment (MUCHA) trial

Author

Hori, Masatsugu, Sasayama, Sgetake, Kitabatake, Akira, Toyo-oka, Teruhiko, Handa, Shunnosuke, Yokoyama, Mitsuhiro, Matsuzaki, Masunori, Takeshita, Akira, Origasa, Hideki, Matsui, Kennichi, and Hosoda, Saichi

Subjects
Chronic diseases -- Care and treatment, Chronic diseases -- Drug therapy, Chronic diseases -- Patient outcomes, Adrenergic beta blockers -- Dosage and administration, Heart failure -- Care and treatment, Heart failure -- Drug therapy, Heart failure -- Patient outcomes, Hospital care -- Statistics, Health
Published
2004

47. Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model

Author

Jesmin, Subrina, Hattori, Yuichi, Sakuma, Ichiro, Mowa, Chishimba N., and Kitabatake, Akira

Subjects
Vascular endothelial growth factor -- Genetic aspects, Vascular endothelial growth factor -- Research, Angiotensin -- Physiological aspects, Type 2 diabetes -- Health aspects, Hypoxia -- Health aspects, Gene expression -- Physiological aspects, Candesartan -- Drug therapy, Coronary heart disease -- Care and treatment, Coronary heart disease -- Health aspects, Insulin resistance -- Research, Biological sciences
Abstract

With the use of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of human non-insulin-dependent diabetes mellitus (NIDDM), we assessed whether ANG II is involved in coronary capillary angiogenesis at the insulin-resistant stage of NIDDM (20 wk of age). In OLETF rats, ANG II labeling and angiotensin type 1 (A[T.sub.1]) receptor expression in coronary vessels were increased more than in nondiabetic controls. A marked increase in vascular expression of vascular endothelial growth factor (VEGF) at both mRNA and protein levels was found in OLETF rats. The increased expression level of VEGF was associated with accumulation of hypoxia-inducible factor-1[alpha] (HIF-1[alpha]) activated by increased advanced glycation end products (AGEs). Morphometric analysis showed a significantly increased total coronary capillary density, which was a result of arterialization of the venular capillary portion in OLETF rats. Treatment of OLETF rats with candesartan, an A[T.sub.1] receptor blocker, inhibited vascular expressions of VEGF, HIF-1[alpha], and AGEs, and ameliorated the morphometric changes. These results suggest a key role of ANG II in the pathogenesis of the coronary capillary remodeling in this NIDDM model. vascular endothelial growth factor; hypoxia-inducible factor-1[alpha]; advanced glycation end products; coronary capillary remodeling; angiotensin II; non-insulin-dependent diabetes mellitus

Published
2002

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