Search

Your search keyword '"Kistner K"' showing total 537 results
Start Over Author "Kistner K"

Refine your results

537 results on '"Kistner K"'

10. Vorwort

Author

Feichtinger, G., Kistner, K. -P., Schneeweiß, Ch., and Pfanzagl, J.

Published
1994
Full Text
View/download PDF

11. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block

Author

Brenneis, C., Kistner, K., Puopolo, M., Jo, S., Roberson, D.P., Sisignano, M., Segal, D., Cobos, E.J., Wainger, B.J., Labocha, S., Ferreirós, N., Hehn, C. von, Tran, J., Geisslinger, G., Reeh, P.W., Bean, B.P., Woolf, C.J., and Publica

Abstract

Background and Purpose: Selective nociceptor fibre block is achieved by introducing the cell membrane impermeant sodium channel blocker lidocaine N-ethyl bromide (QX-314) through transient receptor potential V1 (TRPV1) channels into nociceptors. We screened local anaesthetics for their capacity to activate TRP channels, and characterized the nerve block obtained by combination with QX-314. Experimental Approach: We investigated TRP channel activation in dorsal root ganglion (DRG) neurons by calcium imaging and patch-clamp recordings, and cellular QX-314 uptake by MS. To characterize nerve block, compound action potential (CAP) recordings from isolated nerves and behavioural responses were analysed. Key Results: Of the 12 compounds tested, bupivacaine was the most potent activator of ruthenium red-sensitive calcium entry in DRG neurons and activated heterologously expressed TRPA1 channels. QX-314 permeated through TRPA1 channels and accumulated intracellularly after activation of these channels. Upon sciatic injections, QX-314 markedly prolonged bupivacaine's nociceptive block and also extended (to a lesser degree) its motor block. Bupivacaine's blockade of C-, but not A-fibre, CAPs in sciatic nerves was extended by co-application of QX-314. Surprisingly, however, this action was the same in wild-type, TRPA1-knockout and TRPV1/TRPA1-double knockout mice, suggesting a TRP-channel independent entry pathway. Consistent with this, high doses of bupivacaine promoted a non-selective, cellular uptake of QX-314. Conclusions and Implications Bupivacaine, combined with QX-314, produced a long-lasting sensory nerve block. This did not require QX-314 permeation through TRPA1, although bupivacaine activated these channels. Regardless of entry pathway, the greatly extended duration of block produced by QX-314 and bupivacaine may be clinically useful.

Published
2014

15. Book reviews

Author

Schellhaas, H., Goldstein, B., Dinkelbach, W., Uebe, G., Kistner, K. -P., and Zäpfel, G.

Published
1982
Full Text
View/download PDF

16. Buchbesprechungen

Author

Bothe, H., Derigs, U., Kistner, K. -P., Schwarze, J., Noltemeier, H., Jaeger, A., Weber, R., Albers, S., Steinecke, V., and Schmidt, W. P.

Published
1979
Full Text
View/download PDF

20. Buchbesprechungen

Author

Matthäus, F., Schreiber, B., Knepel, H., Liesegang, G., Horst, R., Golling, H. -J., Meyer zu Selhausen, H., Rausch, K. F., Stewart, Th., Eckhardt, U., Peitgen, H. -O., Pressmar, D. B., Streim, H., Ropohl, G., Kistner, K. -P., Müller-Merbach, H., Brockhoff, K., Ihde, G. -B., Schwarze, J., Scholz, Ch., Dathe, J., Leitherer, E., Saase, Lydia, Bayer, G., Bamberg, G., and Firchau, V.

Published
1982
Full Text
View/download PDF

22. Book reviews

Author

Avenhaus, R., Brucker, P., Luhmer, A., Möhring, R. H., Radermacher, F. J., Kistner, K. -P., Brandenburg, V., and Uebe, G.

Published
1983
Full Text
View/download PDF

26. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block

Author

Brenneis, C, primary, Kistner, K, additional, Puopolo, M, additional, Jo, S, additional, Roberson, DP, additional, Sisignano, M, additional, Segal, D, additional, Cobos, E J, additional, Wainger, B J, additional, Labocha, S, additional, Ferreirós, N, additional, von Hehn, C, additional, Tran, J, additional, Geisslinger, G, additional, Reeh, P W, additional, Bean, B P, additional, and Woolf, C J, additional

Published
2013
Full Text
View/download PDF

34. Study of the role of antimicrobial glucosinolate-derived isothiocyanates in resistance of Arabidopsis to microbial pathogens.

Author

Tierens, K F, Thomma, B P, Brouwer, M, Schmidt, J, Kistner, K, Porzel, A, Mauch-Mani, B, Cammue, B P, and Broekaert, W F

Abstract

Crude aqueous extracts from Arabidopsis leaves were subjected to chromatographic separations, after which the different fractions were monitored for antimicrobial activity using the fungus Neurospora crassa as a test organism. Two major fractions were obtained that appeared to have the same abundance in leaves from untreated plants versus leaves from plants challenge inoculated with the fungus Alternaria brassicicola. One of both major antimicrobial fractions was purified to homogeneity and identified by 1H nuclear magnetic resonance, gas chromatography/electron impact mass spectrometry, and gas chromatography/chemical ionization mass spectrometry as 4-methylsulphinylbutyl isothiocyanate (ITC). This compound has previously been described as a product of myrosinase-mediated breakdown of glucoraphanin, the predominant glucosinolate in Arabidopsis leaves. 4-Methylsulphinylbutyl ITC was found to be inhibitory to a wide range of fungi and bacteria, producing 50% growth inhibition in vitro at concentrations of 28 microM for the most sensitive organism tested (Pseudomonas syringae). A previously identified glucosinolate biosynthesis mutant, gsm1-1, was found to be largely deficient in either of the two major antimicrobial compounds, including 4-methylsulphinylbutyl ITC. The resistance of gsm1-1 was compared with that of wild-type plants after challenge with the fungi A. brassicicola, Plectosphaerella cucumerina, Botrytis cinerea, Fusarium oxysporum, or Peronospora parasitica, or the bacteria Erwinia carotovora or P. syringae. Of the tested pathogens, only F. oxysporum was found to be significantly more aggressive on gsm1-1 than on wild-type plants. Taken together, our data suggest that glucosinolate-derived antimicrobial ITCs can play a role in the protection of Arabidopsis against particular pathogens.

Published
2001
Full Text
View/download PDF

36. OR, Economics and Statistics.

Author

Feichtinger, G., Kistner, K. -P., and Schneeweiss, C.

Subjects
COLLEGE teachers, UNIVERSITIES & colleges, BIRTHDAYS, OPERATIONS research, ECONOMICS, SOCIOLOGY, DEMOGRAPHY, PHILOSOPHY of science
Abstract

Focuses on the celebration of the 75th birthday of Franz Ferschl, professor emeritus for statistics at the University of Munich in Munich, Germany. Interests of Ferschl in operations research, economics, sociology, demography and philosophy of science; Influence of his contributions to assemblage processes, Markovian decision processes, dynamic programming and decision theory on scholars and the field of quantitative economic research on the whole; Work experience at the University of Vienna.

Published
2004

41. Beschreibung der Problemstellung

Author

Missbauer, Hubert, Bohr, K., editor, Bühler, W., editor, Dinkelbach, W., editor, Franke, G., editor, Hammann, P., editor, Kistner, K.-P., editor, Laux, H., editor, Rosenberg, O., editor, Rudolph, B., editor, and Missbauer, Hubert

Published
1998
Full Text
View/download PDF

42. Die Modellierung der Fertigungseinheiten

Author

Missbauer, Hubert, Bohr, K., editor, Bühler, W., editor, Dinkelbach, W., editor, Franke, G., editor, Hammann, P., editor, Kistner, K.-P., editor, Laux, H., editor, Rosenberg, O., editor, Rudolph, B., editor, and Missbauer, Hubert

Published
1998
Full Text
View/download PDF

43. Ziele und Inhalt der Arbeit

Author

Missbauer, Hubert, Bohr, K., editor, Bühler, W., editor, Dinkelbach, W., editor, Franke, G., editor, Hammann, P., editor, Kistner, K.-P., editor, Laux, H., editor, Rosenberg, O., editor, Rudolph, B., editor, and Missbauer, Hubert

Published
1998
Full Text
View/download PDF

44. Die Bedeutung der neueren PPS-Konzepte

Author

Missbauer, Hubert, Bohr, K., editor, Bühler, W., editor, Dinkelbach, W., editor, Franke, G., editor, Hammann, P., editor, Kistner, K.-P., editor, Laux, H., editor, Rosenberg, O., editor, Rudolph, B., editor, and Missbauer, Hubert

Published
1998
Full Text
View/download PDF

46. Unschärfenmodellierung durch Fuzzy Sets

Author

Hauke, Wolfgang, Bohr, K., editor, Bühler, W., editor, Dinkelbach, W., editor, Franke, G., editor, Hammann, P., editor, Kistner, K.-P., editor, Laux, H., editor, Rosenberg, O., editor, Rudolph, B., editor, and Hauke, Wolfgang

Published
1998
Full Text
View/download PDF

47. Grundlagen unscharfer Entscheidungsmodelle

Author

Hauke, Wolfgang, Bohr, K., editor, Bühler, W., editor, Dinkelbach, W., editor, Franke, G., editor, Hammann, P., editor, Kistner, K.-P., editor, Laux, H., editor, Rosenberg, O., editor, Rudolph, B., editor, and Hauke, Wolfgang

Published
1998
Full Text
View/download PDF

48. Unscharfe lineare Optimierung

Author

Hauke, Wolfgang, Bohr, K., editor, Bühler, W., editor, Dinkelbach, W., editor, Franke, G., editor, Hammann, P., editor, Kistner, K.-P., editor, Laux, H., editor, Rosenberg, O., editor, Rudolph, B., editor, and Hauke, Wolfgang

Published
1998
Full Text
View/download PDF

50. Unternehmensplanung und Unschärfe

Author

Hauke, Wolfgang, Bohr, K., editor, Bühler, W., editor, Dinkelbach, W., editor, Franke, G., editor, Hammann, P., editor, Kistner, K.-P., editor, Laux, H., editor, Rosenberg, O., editor, Rudolph, B., editor, and Hauke, Wolfgang

Published
1998
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results