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1. Twenty-Year Trends in the Incidence and Outcome of Cardiogenic Shock in AMIS Plus Registry

Author

Hunziker, Lukas, Radovanovic, Dragana, Jeger, Raban, Pedrazzini, Giovanni, Cuculi, Florim, Urban, Philip, Erne, Paul, Rickli, Hans, Pilgrim, Thomas, Hess, F., Simon, R., Hangartner, P.J., Hufschmid, U., Hornig, B., Altwegg, L., Trummler, S., Windecker, S., Rueff, T., Loretan, P., Roethlisberger, C., Evéquoz, D., Mang, G., Ryser, D., Müller, P., Jecker, R., Kistler, W., Hongler, T., Stäuble, S., Freiwald, G., Schmid, H.P., Stauffer, J.C., Cook, S., Bietenhard, K., Roffi, M., Wojtyna, W., Schönenberger, R., Simonin, C., Waldburger, R., Schmidli, M., Federspiel, B., Weiss, E.M., Marty, H., Weber, K., Zender, H., Poepping, I., Hugi, A., Koltai, E., Iglesias, J.F., Erne, P., Heimes, T., Jordan, B., Pagnamenta, A., Feraud, P., Beretta, E., Stettler, C., Repond, F., Widmer, F., Heimgartner, C., Polikar, R., Bassetti, S., Iselin, H.U., Giger, M., Egger, P., Kaeslin, T., Fischer, A., Herren, T., Eichhorn, P., Neumeier, C., Flury, G., Girod, G., Vogel, R., Niggli, B., Yoon, S., Nossen, J., Stoller, U., Veragut, U.P., Bächli, E., Weber, A., Schmidt, D., Hellermann, J., Eriksson, U., Fischer, T., Peter, M., Gasser, S., Fatio, R., Vogt, M., Ramsay, D., Wyss, C., Bertel, O., Maggiorini, M., Eberli, F., and Christen, S.

Published
2019
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2. Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers

Author

Maurer, D. J. (Debbie J.), Liu, C. (Chengyao), Xepapadaki, P. (Paraskevi), Stanic, B. (Barbara), Bachert, C. (Claus), Finotto, S. (Susetta), Gao, Y.-D. (Ya-Dong), Graser, A. (Anna), Jartti, T. (Tuomas), Kistler, W. (Walter), Kowalski, M. (Marek), Lukkarinen, H. (Heikki), Pasioti, M. (Maria), Tan, G. (Ge), Villiger, M. (Michael), Zhang, L. (Luo), Zhang, N. (Nan), Akdis, M. (Mübeccel), Papadopoulos, N. G. (Nikolaos G.), Akdis, C. A. (Cezmi A.), Maurer, D. J. (Debbie J.), Liu, C. (Chengyao), Xepapadaki, P. (Paraskevi), Stanic, B. (Barbara), Bachert, C. (Claus), Finotto, S. (Susetta), Gao, Y.-D. (Ya-Dong), Graser, A. (Anna), Jartti, T. (Tuomas), Kistler, W. (Walter), Kowalski, M. (Marek), Lukkarinen, H. (Heikki), Pasioti, M. (Maria), Tan, G. (Ge), Villiger, M. (Michael), Zhang, L. (Luo), Zhang, N. (Nan), Akdis, M. (Mübeccel), Papadopoulos, N. G. (Nikolaos G.), and Akdis, C. A. (Cezmi A.)

Abstract

Background: The impact of physical activity on immune response is a hot topic in exercise immunology, but studies involving asthmatic children are scarce. Our aims were to examine whether there were any differences in the level of physical activity and daily TV attendance, to assess its role on asthma control and immune responses to various immune stimulants. Methods: Weekly physical activity and daily television attendance were obtained from questionnaires at inclusion of the PreDicta study. PBMC cultures were stimulated with phytohemagglutinin (PHA), R848, poly I:C, and zymosan. A panel of cytokines was measured and quantified in cell culture supernatants using luminometric multiplex immunofluorescence beads-based assay. Results: Asthmatic preschoolers showed significantly more TV attendance than their healthy peers (58.6% vs. 41.5% 1–3 h daily and only 25.7% vs. 47.2% ≤1 h daily) and poor asthma control was associated with less frequent physical activity (PA) (75% no or occasional activity in uncontrolled vs. 20% in controlled asthma; 25% ≥3 times weekly vs. 62%). Asthmatics with increased PA exhibited elevated cytokine levels in response to polyclonal stimulants, suggesting a readiness of circulating immune cells for type 1, 2, and 17 cytokine release compared to subjects with low PA and high TV attendance. This may also represent a proinflammatory state in high PA asthmatic children. Low physical activity and high TV attendance were associated with a decrease in proinflammatory cytokines. Proinflammatory cytokines were correlating with each other in in vitro immune responses of asthmatic children, but not healthy controls, this correlation was more pronounced in children with sedentary behavior. Conclusion: Asthmatic children show more sedentary behavior than healthy subjects, while poor asthma control is associated with a substantial decrease in physical activity. Our results suggest that asthmatic children may profit from regular exercise, as elevate

Published
2022

4. Temporal trends in the treatment and outcomes of elderly patients with acute coronary syndrome

Author

Schoenenberger, Andreas W., Radovanovic, Dragana, Windecker, Stephan, Iglesias, Juan F., Pedrazzini, Giovanni, Stuck, Andreas E., Erne, Paul, Lessing, P, Hess, F, Simon, R, Hangartner, PJ, Hufschmid, U, Hornig, B, Jeger, R, Trummler, S, Windecker, S, Rueff, T, Loretan, P, Roethlisberger, C, Evéquoz, D, Mang, G, Ryser, D, Jecker, R, Kistler, W, Droll, A., Stäuble, S, Freiwald, G, Schmid, HP, Stauffer, JC, Cook, S, Bietenhard, K, Roffi, M, Wojtyna, W., Schönenberger, R, Waldburger, R, Schmidli, M, Federspiel, B, Weiss, EM, Weber, K, Zender, H, Poepping, I, Hugi, A, Koltai, E, Pedrazzini, G, Erne, P, Cuculi, F., Heimes, T, Pagnamenta, A, Urban, P, Stettler, C, Repond, F, Widmer, F, Heimgartner, C, Polikar, R, Bassetti, S, Iselin, HU, Giger, M, Egger, P, Kaeslin, T, Fischer, A, Herren, T, Eichhorn, P, Neumeier, C, Flury, G, Girod, G, Vogel, R, Niggli, B, Rickli, H, Yoon, S, Nossen, J, Stoller, U, Bächli, E, Weber, A, Schmidt, D, Hellermann, J, Eriksson, U, Fischer, T, Peter, M, Gasser, S, Fatio, R, Vogt, M, Ramsay, D, Bertel, O, Maggiorini, M, Eberli, F, and Christen, S

Published
2016
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7. Validity of Charlson Comorbidity Index in patients hospitalised with acute coronary syndrome. Insights from the nationwide AMIS Plus registry 2002–2012

Author

Radovanovic, Dragana, Seifert, Burkhardt, Urban, Philip, Eberli, Franz R, Rickli, Hans, Bertel, Osmund, Puhan, Milo A, Erne, Paul, Lessing, P, Hess, F, Simon, R, Hangartner, PJ, Hufschmid, U, Hunziker, P, Jeger, R, Grädel, C, Hornig, B, Schönfelder, A, Windecker, S, Rueff, T, Loretan, P, Schläpfer, H, Roethlisberger, C, Evéquoz, D, Mang, G, Ryser, D, Niedermaier, G, Kistler, W, Droll, A, Hongler, T, Stäuble, S, Freiwald, G, Schmid, HP, Stauffer, JC, Cook, S, Bietenhard, K, Gaspoz, JM, Keller, PF, Wojtyna, W, Oertli, B, Schönenberger, R, Schmidli, M, Federspiel, B, Schröpfer, D, Weiss, EM, Weber, K, Zender, H, Steffen, C, Poepping, I, Hugi, A, Frei, J, Koltai, E, Pedrazzini, G, Erne, P, Heimes, T, Pagnamenta, A, Urban, P, Stettler, C, Repond, F, Widmer, F, Heimgartner, C, Polikar, R, Bassetti, S, Iselin, HU, Giger, M, Egger, P, Kaeslin, T, Frey, R, Fischer, A, Herren, T, Caduff, B, Eichhorn, P, Neumeier, C, Flury, G, Girod, G, Grêt, A, Schönenberger, R, Vogel, R, Niggli, B, Rickli, H, Yoon, S, Stoller, U, Bächli, E, Schmidt, D, Hellermann, J, Graber, M, Vontobel, H, Eriksson, U, Haller, A, Fischer, T, Peter, M, Gasser, S, Fatio, R, Bertel, O, Maggiorini, M, Eberli, F, Fischler, M, Christen, S, and Buchholz, S

Published
2014
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9. Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis

Author

Lemeille, Sylvain, primary, Paschaki, Marie, additional, Baas, Dominique, additional, Morlé, Laurette, additional, Duteyrat, Jean-Luc, additional, Ait-Lounis, Aouatef, additional, Barras, Emmanuèle, additional, Soulavie, Fabien, additional, Jerber, Julie, additional, Thomas, Joëlle, additional, Zhang, Yong, additional, Holtzman, Michael J, additional, Kistler, W Stephen, additional, Reith, Walter, additional, and Durand, Bénédicte, additional

Published
2020
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17. RFX2 Is a Major Transcriptional Regulator of Spermiogenesis

Author

Kistler, W. Stephen, Baas, Dominique, Lemeille, Sylvain, Paschaki, Marie, Seguin-Estevez, Queralt, Barras, Emmanuèle, Ma, Wenli, Duteyrat, Jean-Luc, Morlé, Laurette, Durand, Bénédicte, and Reith, Walter

Subjects
Male, Transcription, Genetic, lcsh:QH426-470, Apoptosis, Regulatory Factor X Transcription Factors, ddc:616.07, Cyclic AMP Response Element Modulator, Mice, Spermatocytes, Cell Adhesion, Animals, Cilia, Spermatogenesis, Cytoskeleton, Infertility, Male, Mice, Knockout, TATA-Binding Protein Associated Factors, Gene Expression Profiling, Spermatids, DNA-Binding Proteins, Mice, Inbred C57BL, lcsh:Genetics, Gene Expression Regulation, Transcription Factor TFIID, Research Article, Transcription Factors
Abstract

Spermatogenesis consists broadly of three phases: proliferation of diploid germ cells, meiosis, and finally extensive differentiation of the haploid cells into effective delivery vehicles for the paternal genome. Despite detailed characterization of many haploid developmental steps leading to sperm, only fragmentary information exists on the control of gene expression underlying these processes. Here we report that the RFX2 transcription factor is a master regulator of genes required for the haploid phase. A targeted mutation of Rfx2 was created in mice. Rfx2-/- mice are perfectly viable but show complete male sterility. Spermatogenesis appears to progress unperturbed through meiosis. However, haploid cells undergo a complete arrest in spermatid development just prior to spermatid elongation. Arrested cells show altered Golgi apparatus organization, leading to a deficit in the generation of a spreading acrosomal cap from proacrosomal vesicles. Arrested cells ultimately merge to form giant multinucleated cells released to the epididymis. Spermatids also completely fail to form the flagellar axoneme. RNA-Seq analysis and ChIP-Seq analysis identified 139 genes directly controlled by RFX2 during spermiogenesis. Gene ontology analysis revealed that genes required for cilium function are specifically enriched in down- and upregulated genes showing that RFX2 allows precise temporal expression of ciliary genes. Several genes required for cell adhesion and cytoskeleton remodeling are also downregulated. Comparison of RFX2-regulated genes with those controlled by other major transcriptional regulators of spermiogenesis showed that each controls independent gene sets. Altogether, these observations show that RFX2 plays a major and specific function in spermiogenesis., Author Summary Failure of spermatogenesis, which is presumed to often result from genetic defects, is a common cause of male sterility. Although numerous genes associated with defects in male spermatogenesis have been identified, numerous cases of genetic male infertility remain unelucidated. We report here that the transcription factor RFX2 is a master regulator of gene expression programs required for progression through the haploid phase of spermatogenesis. Male RFX2-deficient mice are completely sterile. Spermatogenesis progresses through meiosis, but haploid cells undergo a complete block in development just prior to spermatid elongation. Gene expression profiling and ChIP-Seq analysis revealed that RFX2 controls key pathways implicated in cilium/flagellum formation, as well as genes implicated in microtubule and vesicle associated transport. The set of genes activated by RFX2 in spermatids exhibits virtually no overlap with those controlled by other known transcriptional regulators of spermiogenesis, establishing RFX2 as an essential new player in this developmental process. RFX2-deficient mice should therefore represent a valuable new model for deciphering the regulatory networks that direct sperm formation, and thereby contribute to the identification of causes of human male infertility.

Published
2015

19. Legionellose, ein Tourismusproblem?

Author

Kistler W, Walter H. Reinhart, Wieland T, and Fleisch F

Subjects
Cross infection, medicine.medical_specialty, International mobility, biology, business.industry, Legionella, Task force, General Medicine, medicine.disease, biology.organism_classification, LEGIONELLA INFECTIONS, Epidemiology, medicine, Legionnaires' disease, Intensive care medicine, business, Rare disease
Abstract

La légionellose, un problème de tourisme? La légionellose est une maladie assez rare, mais elle suit souvent un cours prolongé et compliqué, même chez des patients immunocompétents. Le diagnostic est important pour des raisons thérapeutiques et épidémiologiques. De 1998 à 2001 on a observé à l'hôpital cantonal de Coire six cas de légionellose, dont quatre étaient associés aux voyages et un autre concernait un employé d'un hôtel local. Par suite de l'augmentation de la mobilité internationale les recherches épidémiologiques sur la localisation de la source infectieuse et les procédés hygiéniques deviennent plus difficiles. Une organisation européenne, le «European Working Group for Legionella Infections» (EWGLI/www.ewgli.org) a étudié ce problème. La question de la forme sous laquelle le public doit être informé des sources de légionelles fait l'object d'une discussion.

Published
2002
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27. Colaboradores

Author

Bagot, Catherine N., Bannon, Gary A., Baynes, John W., Beastall, Graham, Bielarczyk, Hanna, Broom, John I., Carver, Wayne E., Dominiczak, Marek H., Elbein, Alan D., Farrell, Alex, Fraser, William D., Frizzell, Norma, Fujii, Junichi, Goodridge, Helen S., Gracie, J. Alastair, Gugliucci, Alejandro, Harnett, Margaret M., Heales, Simon J.R., Helmkamp Jr., George M., Honke, Koichi, Hunt, D. Margaret, Jamieson, Andrew, Jones, Alan F., Karpe, Fredrik, Kaushal, Gur P., Kistler, W. Stephen, Kolch, Walter, Kostek, Matthew C., Kulkarni, Utkarsh V., Logue, Jennifer, Lowe, Gordon D.O., Maeda, Masatomo, Michie, Alison M., Nagai, Ryoji, Patton, Jeffrey R., Paunović, Verica, Pitt, Andrew R., Priest, Matthew, Rawitch, Allen B., Salt, Ian P., Semple, Robert K., Stillway, L. William, Szczepańska-Konkel, Mirosława, Szutowicz, Andrzej, Taniguchi, Naoyuki, Teoh, Yee Ping, Thompson, Edward J., Thornburg, Robert, and Wallace, A. Michael

Published
2015
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36. Contributors

Author

Bagot, Catherine N., Bannon, Gary A., Baynes, John W., Beastall, Graham, Bielarczyk, Hanna, Broom, John I., Carver, Wayne E., Dominiczak, Marek H., Elbein, Alan D., Farrell, Alex, Fraser, William D., Frizzell, Norma, Fujii, Junichi, Goodridge, Helen S., Gracie, J. Alastair, Gugliucci, Alejandro, Harnett, Margaret M., Heales, Simon J.R., Helmkamp, George M., Jr., Honke, Koichi, Hunt, D. Margaret, Jamieson, Andrew, Jones, Alan F., Karpe, Fredrik, Kaushal, Gur P., Kistler, W. Stephen, Kolch, Walter, Kostek, Matthew C., Kulkarni, Utkarsh V., Logue, Jennifer, Lowe, Gordon D.O., Maeda, Masatomo, Michie, Alison M., Nagai, Ryoji, Patton, Jeffrey R., Paunović, Verica, Pitt, Andrew R., Priest, Matthew, Rawitch, Allen B., Salt, Ian P., Semple, Robert K., Stillway, L. William, Szczepańska-Konkel, Mirosława, Szutowicz, Andrzej, Taniguchi, Naoyuki, Teoh, Yee Ping, Thompson, Edward J., Thornburg, Robert, and Wallace, A. Michael

Published
2014
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37. Erratum: Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice

Author

Hoogenraad, C C, primary, Koekkoek, B, additional, Akhmanova, A, additional, Krugers, H, additional, Dortland, B, additional, Miedema, M, additional, van Alphen, A, additional, Kistler, W M, additional, Jaegle, M, additional, Koutsourakis, M, additional, Camp, N Van, additional, Verhoye, M, additional, van der Linden, A, additional, Kaverina, I, additional, Grosveld, F, additional, Zeeuw, C I De, additional, and Galjart, N, additional

Published
2002
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