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2. Thermal ablation versus surgical resection of small-size colorectal liver metastases (COLLISION): an international, randomised, controlled, phase 3 non-inferiority trial

Author

van der Lei, Susan, Puijk, Robbert S, Dijkstra, Madelon, Schulz, Hannah H, Vos, Danielle J W, De Vries, Jan J J, Scheffer, Hester J, Lissenberg-Witte, Birgit I, Aldrighetti, Luca, Arntz, Mark, Barentsz, Maarten W, Besselink, Marc G, Bracke, Bart, Bruijnen, Rutger C G, Buffart, Tineke E, Burgmans, Mark C, Chapelle, Thierry, Coolsen, Marielle M E, de Boer, Sanne W, de Cobelli, Francesco, de Jong, Koert, de Wilt, Johannes H W, Diederik, Arjen L, Dooper, Anniek M C, Draaisma, Werner A, Eker, Hasan H, Erdmann, Joris I, Futterer, Jurgen J, Geboers, Bart, Groot, Gerie M C, Hagendoorn, Jeroen, Hartgrink, Henk H, Horsthuis, Karin, Hurks, Rob, Jenniskens, Sjoerd F M, Kater, Matthijs, Kazemier, Geert, Kist, Jakob W, Klaase, Joost M, Knapen, Robrecht R M M, Kruimer, Johan W H, Lamers, Armand B G N, Leclercq, Wouter K G, Liefers, Gerrit-Jan, Manusama, Eric R, Meier, Mark A J, Melenhorst, Marleen C A M, Mieog, J Sven D, Molenaar, Quintus I, Nielsen, Karin, Nijkamp, Maarten W, Nieuwenhuijs, Vincent B, Nota, Irene M G C, Op de Beeck, Bart, Overduin, Christiaan G, Patijn, Gijs A, Potters, Fons H, Ratti, Francesca, Rietema, Floris J, Ruiter, Simeon J S, Schouten, Evelien A C, Schreurs, Wilhelmina H, Serafino, Gianpiero, Sietses, Colin, Slooter, Gerrit D, Smits, Maarten L J, Soykan, Ezgi A, Spaargaren, Gert-Jan, Stommel, Martijn W J, Timmer, Florentine E F, van Baardewijk, Laurens J, van Dam, Ronald M, van Delden, Otto M, van den Bemd, Bente A T, van den Bergh, Janneke E, van den Boezem, Peter B, van der Leij, Christiaan, van der Meer, Rutger W, van der Meijs, Bram B M, van der Ploeg, Augustinus P T, van der Reijden, Jeroen J, van Duijvendijk, Peter, van Erkel, Arian R, van Geel, Anne M, Van Heek, N Tjarda, van Manen, Christiaan J, van Rijswijk, Carla S P, van Waesberghe, Jan Hein T M, Versteeg, Kathelijn S, Vink, Ted, Zijlstra, Ijsbrand A J, Zonderhuis, Barbara M, Swijnenburg, Rutger-Jan, van den Tol, M Petrousjka, and Meijerink, Martijn R

Published
2025
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6. Clinical Outcomes of Biliary Drainage in Patients with Malignant Biliary Obstruction Caused by Colorectal Cancer Metastases

Author

Cancer, MS MDL 1, Arts-assistenten Radiologie, MS Radiologie, MS Medische Oncologie, Kastelijn, Janine B, Moons, Leon M G, Kist, Jakob W, Prince, Jip F, van Leeuwen, Maarten S, Koopman, Miriam, Vleggaar, Frank P, Cancer, MS MDL 1, Arts-assistenten Radiologie, MS Radiologie, MS Medische Oncologie, Kastelijn, Janine B, Moons, Leon M G, Kist, Jakob W, Prince, Jip F, van Leeuwen, Maarten S, Koopman, Miriam, and Vleggaar, Frank P

Published
2023

8. Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm

Author

Lodewijk, Lutske, Kluijfhout, Wouter P., Kist, Jakob W., Stegeman, Inge, Plukker, John T. M., Nieveen van Dijkum, Els J., Bonjer, H. Jaap, Bouvy, Nicole D., Schepers, Abbey, de Wilt, Johannes H. W., Netea-Maier, Romana T., van der Hage, Jos A., Burger, Jacobus W. A., Ho, Gavin, Lee, Wayne S., Shen, Wen T., Aronova, Anna, Zarnegar, Rasa, Benay, Cassandre, Mitmaker, Elliot J., Sywak, Mark S., Aniss, Ahmad M., Kruijff, Schelto, James, Benjamin, Grogan, Raymon H., Brunaud, Laurent, Hoch, Guillaume, Pandolfi, Chiara, Ruan, Daniel T., Jones, Michael D., Guerrero, Marlon A., Valk, Gerlof D., Borel Rinkes, Inne H. M., and Vriens, Menno R.

Published
2016
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9. Clinical Outcomes of Biliary Drainage in Patients with Malignant Biliary Obstruction Caused by Colorectal Cancer Metastases.

Author

Kastelijn, Janine B., Moons, Leon M. G., Kist, Jakob W., Prince, Jip F., van Leeuwen, Maarten S., Koopman, Miriam, and Vleggaar, Frank P.

Abstract

Background and aim: Malignant biliary obstruction is an ominous complication of metastatic colorectal cancer (mCRC) that is challenging to solve. Biliary drainage can be performed to relieve symptoms of jaundice, treat cholangitis, or enable palliative systemic therapy. The aim of this study is to evaluate clinical outcomes of biliary drainage of malignant biliary obstruction in mCRC patients. Methods: Consecutive patients with malignant biliary obstruction due to mCRC who underwent endoscopic retrograde cholangiopancreatography or percutaneous transhepatic cholangiography were included. Patient, disease, and procedural characteristics and outcomes were retrospectively collected from electronic medical records. Radiological data were prospectively reassessed. Main outcome was functional success, i.e. achievement of the intended goal of biliary drainage. Prognostic factors for functional success and survival were assessed. Results: Thirty-seven patients were included. Functional success was achieved in 18 (50%) patients. Seventeen (46%) patients experienced adverse events (suspected to be) related to the procedure. Median overall survival after biliary drainage was 61 days (IQR 31–113). No prognostic factors of functional success were identified. Performance status, presence of the primary tumor, ascites, ≥ 5 intrahepatic metastases, estimated hepatic invasion of > 50% and above-median levels of bilirubin and lactate dehydrogenase were significantly associated with poorer survival. Improved survival was seen in patients with technical, functional, or biochemical success, and with subsequent oncologic treatment. Conclusions: Functional successful biliary drainage was achieved in half of the patients. Adverse events also occurred in nearly half of the patients. We observed a significantly longer survival in whom biliary drainage allowed palliative oncologic therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Fast-track Radioiodine Ablation Therapy After Thyroidectomy Reduces Sick Leave in Patients With Differentiated Thyroid Cancer (FASTHYNA Trial)

Author

Zorgeenheid Vaatchirurgie Medisch, Arts-assistenten Radiologie, MS CGO, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, MS Radiologie, Cancer, MS Endocriene Oncologie, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, Waissi, Farahnaz, Kist, Jakob W, Lodewijk, Lutske, de Wit, Ardine G, van der Hage, Jos A, van Dalen, Thijs, de Keizer, Bart, Valk, Gerlof D, Borel Rinkes, Inne H M, Vriens, Menno R, Zorgeenheid Vaatchirurgie Medisch, Arts-assistenten Radiologie, MS CGO, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, MS Radiologie, Cancer, MS Endocriene Oncologie, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, Waissi, Farahnaz, Kist, Jakob W, Lodewijk, Lutske, de Wit, Ardine G, van der Hage, Jos A, van Dalen, Thijs, de Keizer, Bart, Valk, Gerlof D, Borel Rinkes, Inne H M, and Vriens, Menno R

Published
2019

18. Follow-up of patients with thyroglobulin-antibodies: Rising Tg-Ab trend is a risk factor for recurrence of differentiated thyroid cancer

Author

Heelkunde Opleiding, Other research (not in main researchprogram), MS CGO, Cancer, MS Radiologie, MS Endocriene Oncologie, Regenerative Medicine and Stem Cells, de Meer, Siegrid G A, Vorselaars, Wessel M C M, Kist, Jakob W, Stokkel, Marcel P M, de Keizer, Bart, Valk, Gerlof D, Borel Rinkes, Inne H M, Vriens, Menno R, Heelkunde Opleiding, Other research (not in main researchprogram), MS CGO, Cancer, MS Radiologie, MS Endocriene Oncologie, Regenerative Medicine and Stem Cells, de Meer, Siegrid G A, Vorselaars, Wessel M C M, Kist, Jakob W, Stokkel, Marcel P M, de Keizer, Bart, Valk, Gerlof D, Borel Rinkes, Inne H M, and Vriens, Menno R

Published
2017

19. THYROPET study: Is it biology or technology that is the issue? Reply

Author

MS CGO, Cancer, MS Radiologie, Arts-assistenten Radiotherapie, Kist, Jakob W., De Keizer, Bart, Hoekstra, Otto S., Vogel, Wouter V., MS CGO, Cancer, MS Radiologie, Arts-assistenten Radiotherapie, Kist, Jakob W., De Keizer, Bart, Hoekstra, Otto S., and Vogel, Wouter V.

Published
2017

22. Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm

Author

MS CGO, Cancer, MS Interne Geneeskunde, MS Endocriene Oncologie, Regenerative Medicine and Stem Cells, MS HOD, Heelkunde Opleiding, Lodewijk, Lutske, Kluijfhout, Wouter P., Kist, Jakob W., Stegeman, Inge, Plukker, John T. M., van Dijkum, Els J. Nieveen, Bonjer, H. Jaap, Bouvy, Nicole D., Schepers, Abbey, de Wilt, Johannes H. W., Netea-Maier, Romana T., van der Hage, Jos A., Burger, Jacobus W. A., Ho, Gavin, Lee, Wayne S., Shen, Wen T., Aronova, Anna, Zarnegar, Rasa, Benay, Cassandre, Mitmaker, Elliot J., Sywak, Mark S., Aniss, Ahmad M., Kruijff, Schelto, James, Benjamin, Grogan, Raymon H., Brunaud, Laurent, Hoch, Guillaume, Pandolfi, Chiara, Ruan, Daniel T., Jones, Michael D., Guerrero, Marlon A., Valk, Gerlof D., Rinkes, Inne H. M. Borel, Vriens, Menno R., MS CGO, Cancer, MS Interne Geneeskunde, MS Endocriene Oncologie, Regenerative Medicine and Stem Cells, MS HOD, Heelkunde Opleiding, Lodewijk, Lutske, Kluijfhout, Wouter P., Kist, Jakob W., Stegeman, Inge, Plukker, John T. M., van Dijkum, Els J. Nieveen, Bonjer, H. Jaap, Bouvy, Nicole D., Schepers, Abbey, de Wilt, Johannes H. W., Netea-Maier, Romana T., van der Hage, Jos A., Burger, Jacobus W. A., Ho, Gavin, Lee, Wayne S., Shen, Wen T., Aronova, Anna, Zarnegar, Rasa, Benay, Cassandre, Mitmaker, Elliot J., Sywak, Mark S., Aniss, Ahmad M., Kruijff, Schelto, James, Benjamin, Grogan, Raymon H., Brunaud, Laurent, Hoch, Guillaume, Pandolfi, Chiara, Ruan, Daniel T., Jones, Michael D., Guerrero, Marlon A., Valk, Gerlof D., Rinkes, Inne H. M. Borel, and Vriens, Menno R.

Published
2016

23. Thyroid ultrasound-guided fine-needle aspiration: The positive influence of on-site adequacy assessment and number of needle passes on diagnostic cytology rate

Author

Onderzoek Beeld, MS CGO, Cancer, Heelkunde Opleiding, Regenerative Medicine and Stem Cells, Divisie Beeld & Oncologie, MS HOD, MS Interne Geneeskunde, MS Endocriene Oncologie, MS Radiologie, de Koster, Elizabeth J., Kist, Jakob W., Vriens, Menno R., Rinkes, Inne H M Borel, Valk, Gerlof D., De Keizer, Bart, Onderzoek Beeld, MS CGO, Cancer, Heelkunde Opleiding, Regenerative Medicine and Stem Cells, Divisie Beeld & Oncologie, MS HOD, MS Interne Geneeskunde, MS Endocriene Oncologie, MS Radiologie, de Koster, Elizabeth J., Kist, Jakob W., Vriens, Menno R., Rinkes, Inne H M Borel, Valk, Gerlof D., and De Keizer, Bart

Published
2016

25. Calibration of PET/CT scanners for multicenter studies on differentiated thyroid cancer with 124I

Author

MS CGO, Cancer, MS Radiologie, Arts-assistenten Radiotherapie, Kist, Jakob W., van der Vlies, Manfred, Hoekstra, Otto S., Greuter, Henri N J M, de Keizer, Bart, Stokkel, Marcel P M, V. Vogel, Wouter, Huisman, Marc C., van Lingen, Arthur, MS CGO, Cancer, MS Radiologie, Arts-assistenten Radiotherapie, Kist, Jakob W., van der Vlies, Manfred, Hoekstra, Otto S., Greuter, Henri N J M, de Keizer, Bart, Stokkel, Marcel P M, V. Vogel, Wouter, Huisman, Marc C., and van Lingen, Arthur

Published
2016

26. Quantitative Comparison of 124I PET/CT and 131I SPECT/CT Detectability

Author

Fysica Radiologie, Cancer, MS CGO, Beeldverwerking ISI, MS Radiologie, Beijst, Casper, Kist, Jakob W, Elschot, Mattijs, Viergever, Max A, Hoekstra, Otto S, de Keizer, B, de Jong, Hugo W A M, Fysica Radiologie, Cancer, MS CGO, Beeldverwerking ISI, MS Radiologie, Beijst, Casper, Kist, Jakob W, Elschot, Mattijs, Viergever, Max A, Hoekstra, Otto S, de Keizer, B, and de Jong, Hugo W A M

Published
2016

28. Robotgeassisteerde transaxillaire schildklieroperatie

Author

Vriens, Menno R, Kist, Jakob W, Lodewijk, Lutske, van Hillegersberg, Richard, Borel Rinkes, Inne H M, and Radiology and nuclear medicine

Abstract

The robot-assisted transaxillary (hemi)thyroidectomy (RATT) is a new surgical technique using the da Vinci S surgery robot. This technique has recently been successfully introduced in the Netherlands. In a RATT a subcutaneous tunnel from the axilla is created to gain access to the thyroid gland. The operation is then carried out with the robot much like an open procedure. Using a RATT, a total thyroidectomy can be performed. However, surgeons at the beginning of the learning curve are advised to start with hemithyroidectomies only. The indication area consists of nodules up to three centimeters and most probably being benign. The major advantage of this technique is the prevention of a potentially disfiguring scar. The most important disadvantage of this technique is its high cost compared with the conventional procedure. In order to successfully introduce the RATT procedure, thorough preparation by both surgeons and operating room personnel is required. A proctoring program is also necessary.

Published
2013

30. Thyroid incidentalomas in patients with multiple endocrine neoplasia type 1

Author

Lodewijk, Lutske, Bongers, Pim J, Kist, Jakob W, Conemans, Elfi B, de Laat, Joanne M, Pieterman, Carla R C, van der Horst-Schrivers, Anouk N A, Jorna, Ciska, Hermus, Ad R, Dekkers, Olaf M, de Herder, Wouter W, Drent, Madeleine L, Bisschop, Peter H, Havekes, Bas, Rinkes, Inne H M Borel, Vriens, Menno R, Valk, Gerlof D., Lodewijk, Lutske, Bongers, Pim J, Kist, Jakob W, Conemans, Elfi B, de Laat, Joanne M, Pieterman, Carla R C, van der Horst-Schrivers, Anouk N A, Jorna, Ciska, Hermus, Ad R, Dekkers, Olaf M, de Herder, Wouter W, Drent, Madeleine L, Bisschop, Peter H, Havekes, Bas, Rinkes, Inne H M Borel, Vriens, Menno R, and Valk, Gerlof D.

Published
2015

32. The role of qualitative elastography in thyroid nodule evaluation: exploring its target populations

Author

MS CGO, Cancer, MS Medische Oncologie, MS Endocriene Oncologie, MS Radiologie, MS Interne Geneeskunde, Other research (not in main researchprogram), Divisie Beeld & Oncologie, Regenerative Medicine and Stem Cells, Kist, Jakob W., Nell, S, de Keizer, B, Valk, Gerlof D., Borel Rinkes, IHM, Vriens, Menno R., MS CGO, Cancer, MS Medische Oncologie, MS Endocriene Oncologie, MS Radiologie, MS Interne Geneeskunde, Other research (not in main researchprogram), Divisie Beeld & Oncologie, Regenerative Medicine and Stem Cells, Kist, Jakob W., Nell, S, de Keizer, B, Valk, Gerlof D., Borel Rinkes, IHM, and Vriens, Menno R.

Published
2015

33. Thyroid incidentalomas in patients with multiple endocrine neoplasia type 1

Author

Heelkunde Opleiding, MS CGO, Cancer, Unit Opleiding Aios, MS Infectieziekten, MS Endocriene Oncologie, Other research (not in main researchprogram), Lodewijk, Lutske, Bongers, Pim J, Kist, Jakob W, Conemans, Elfi B, de Laat, Joanne M, Pieterman, Carla R C, van der Horst-Schrivers, Anouk N A, Jorna, Ciska, Hermus, Ad R, Dekkers, Olaf M, de Herder, Wouter W, Drent, Madeleine L, Bisschop, Peter H, Havekes, Bas, Rinkes, Inne H M Borel, Vriens, Menno R, Valk, Gerlof D., Heelkunde Opleiding, MS CGO, Cancer, Unit Opleiding Aios, MS Infectieziekten, MS Endocriene Oncologie, Other research (not in main researchprogram), Lodewijk, Lutske, Bongers, Pim J, Kist, Jakob W, Conemans, Elfi B, de Laat, Joanne M, Pieterman, Carla R C, van der Horst-Schrivers, Anouk N A, Jorna, Ciska, Hermus, Ad R, Dekkers, Olaf M, de Herder, Wouter W, Drent, Madeleine L, Bisschop, Peter H, Havekes, Bas, Rinkes, Inne H M Borel, Vriens, Menno R, and Valk, Gerlof D.

Published
2015

34. Qualitative elastography can replace thyroid nodule fine-needle aspiration in patients with soft thyroid nodules. A systematic review and meta-analysis

Author

MS Medische Oncologie, MS Endocriene Oncologie, MS CGO, Cancer, Epi Methoden Team 1, Circulatory Health, MS Radiologie, Divisie Beeld & Oncologie, MS Interne Geneeskunde, Nell, Sjoerd, Kist, Jakob W., Debray, Thomas P A, de Keizer, Bart, Van Oostenbrugge, Timotheus J., Borel Rinkes, Inne H.M., Valk, Gerlof D., Vriens, Menno R., MS Medische Oncologie, MS Endocriene Oncologie, MS CGO, Cancer, Epi Methoden Team 1, Circulatory Health, MS Radiologie, Divisie Beeld & Oncologie, MS Interne Geneeskunde, Nell, Sjoerd, Kist, Jakob W., Debray, Thomas P A, de Keizer, Bart, Van Oostenbrugge, Timotheus J., Borel Rinkes, Inne H.M., Valk, Gerlof D., and Vriens, Menno R.

Published
2015

35. 124I PET/CT to Predict the Outcome of Blind 131I Treatment in Patients with Biochemical Recurrence of Differentiated Thyroid Cancer: Results of a Multicenter Diagnostic Cohort Study (THYROPET)

Author

Kist, Jakob W., primary, de Keizer, Bart, additional, van der Vlies, Manfred, additional, Brouwers, Adrienne H., additional, Huysmans, Dyde A., additional, van der Zant, Friso M., additional, Hermsen, Rick, additional, Stokkel, Marcel P.M., additional, Hoekstra, Otto S., additional, and Vogel, Wouter V., additional

Published
2015
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38. Thyroid incidentalomas in patients with multiple endocrine neoplasia type 1

Author

Lodewijk, Lutske, primary, Bongers, Pim J, additional, Kist, Jakob W, additional, Conemans, Elfi B, additional, de Laat, Joanne M, additional, Pieterman, Carla R C, additional, van der Horst-Schrivers, Anouk N A, additional, Jorna, Ciska, additional, Hermus, Ad R, additional, Dekkers, Olaf M, additional, de Herder, Wouter W, additional, Drent, Madeleine L, additional, Bisschop, Peter H, additional, Havekes, Bas, additional, Rinkes, Inne H M Borel, additional, Vriens, Menno R, additional, and Valk, Gerlof D, additional

Published
2015
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42. Recurrent differentiated thyroid cancer: towards personalized treatment based on evaluation of tumor characteristics with PET (THYROPET Study): study protocol of a multicenter observational cohort study.

Author

Kist, Jakob W., de Keizer, Bart, Stokkel, Marcel P. M., Hoekstra, Otto S., and Vogel, Wouter V.

Subjects
*THYROID cancer treatment, *CANCER relapse, *INDIVIDUALIZED medicine, *THYROGLOBULIN, *PHENOTYPES, CANCER histopathology
Abstract

After initial treatment of differentiated thyroid carcinoma (DTC) patients are followed with thyroglobulin (Tg) measurements to detect recurrences. In case of elevated levels of Tg and negative neck ultrasonography, patients are treated "blindly" with Iodine-131 (131I). However, in up to 50% of patients, the post-therapy scan reveals no 131I-targeting of tumor lesions. Such patients derive no benefit from the blind therapy but are exposed to its toxicity. Alternatively, iodine-124 (124I) Positron Emission Tomography/Computed Tomography (PET/CT) has become available to visualize DTC lesions and without toxicity. In addition to this, 18F-fluorodeoxyglucose (18F-FDG) PET/CT detects the recurrent DTC phenotype, which lost the capacity to accumulate iodine. Taken together, the combination of 124I and 18F-FDG PET/CT has potential to stratify patients for treatment with 131I Methods/design In a multicenter prospective observational cohort study the hypothesis that the combination of 124I and 18F-FDG PET/CT can avoid futile 131I treatments in patients planned for 'blind' therapy with 131I, is tested. One hundred patients planned for 131I undergo both 124I and 18F-FDG PET/CT after rhTSH stimulation. Independent of the outcome of the scans, all patients will subsequently receive, after thyroid hormone withdrawal, the 131I therapy. The post 131I therapeutic scintigraphy is compared with the outcome of the 124I and 18F-FDG PET/CT in order to evaluate the diagnostic value of the combined PET modalities. This study primary aims to reduce the number of futile 131I therapies. Secondary aims are the nationwide introduction of 124I PET/CT by a quality assurance and quality control (QA/QC) program, to correlate imaging outcome with histopathological features, to compare 124I PET/CT after rhTSH and after withdrawal of thyroid hormone, and to compare 124I and 131I dosimetry. Discussion This study aims to evaluate the potential value of the combination of 124I and 18F-FDG PET/CT in the prevention of futile 131I therapies in patients with biochemically suspected recurrence of DTC. To our best knowledge no studies addressed this in a prospective cohort of patients. This is of great clinical importance as a futile 131I is a costly treatment associated with morbidity and therefore should be restricted to those likely to benefit from this treatment. [ABSTRACT FROM AUTHOR]

Published
2014
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45. Letter to the Editor Regarding the Article '124I PET/CT in Patients with Differentiated Thyroid Cancer: Clinical and Quantitative Image Analysis'.

Author

Kist, Jakob W., de Keizer, Bart, and Vogel, Wouter V.

Subjects
*POSITRON emission tomography, THYROID cancer diagnosis
Abstract

A letter to the editor is presented in response to the article "I PET/CT in Patients with Differentiated Thyroid Cancer: Clinical and Quantitative Image Analysis" by S. A. Gulec and colleagues in the previous issue.

Published
2016
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47. 124I PET/CT to Predict the Outcome of Blind 131I Treatment in Patients with Biochemical Recurrence of Differentiated Thyroid Cancer: Results of a Multicenter Diagnostic Cohort Study (THYROPET).

Author

Kist JW, de Keizer B, van der Vlies M, Brouwers AH, Huysmans DA, van der Zant FM, Hermsen R, Stokkel MP, Hoekstra OS, and Vogel WV

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prognosis, Recurrence, Thyroid Neoplasms metabolism, Treatment Outcome, Young Adult, Iodine Radioisotopes therapeutic use, Positron Emission Tomography Computed Tomography, Thyroglobulin metabolism, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms radiotherapy
Abstract

Unlabelled: Patients with suspected recurrence from differentiated thyroid carcinoma, based on an increased thyroglobulin (Tg) level and negative neck ultrasound (US), pose a clinical dilemma. Because standard imaging has a low yield identifying potential recurrence, blind (131)I treatment is often applied. However, a tumor-negative (131)I whole-body scintigraphy (WBS) prevails in 38%-50% of patients. We performed a prospective multicenter observational cohort study to test the hypothesis that (124)I PET/CT can identify the patients with a tumor-negative posttherapy (131)I WBS., Methods: Our study was designed to include 100 patients with detectable Tg and a negative neck US, who were planned for blind (131)I therapy. All patients underwent (124)I PET/CT after administration of recombinant human thyroid-stimulating hormone. Subsequently, after 4-6 wk of thyroid hormone withdrawal patients were treated with 5.5-7.4 GBq of (131)I, followed by WBS a week later. The primary endpoint was the number of (131)I therapies that could have been omitted using the predicted outcome of the (124)I PET/CT, operationalized as the concordance of tumor detection by (124)I PET/CT, using post-(131)I therapy WBS as the reference test. The study would be terminated if 3 patients had a negative (124)I PET/CT and a positive posttherapy (131)I scan., Results: After inclusion of 17 patients, we terminated the study preliminarily because the stopping rule had been met. Median Tg level at (131)I therapy was 28 μg/L (interquartile range, 129). Eight posttherapy WBS were negative (47%), all of which were correctly predicted by negative (124)I PET/CT. Nine posttherapy WBS showed iodine-avid tumor, of which 4 also had positive (124)I PET/CT findings. Sensitivity, specificity, negative predictive value, and positive predictive value of (124)I PET/CT were 44% (confidence interval [CI], 14%-79%), 100% (CI, 63%-100%), 62% (CI, 32%-86%), and 100% (CI, 40%-100%), respectively. Implementation of (124)I PET in this setting would have led to 47% (8/17) less futile (131)I treatments, but 29% of patients (5/17) would have been denied potentially effective therapy., Conclusion: In patients with biochemical evidence of recurrent differentiated thyroid carcinoma and a tumor-negative neck US, the high false-negative rate of (124)I PET/CT after recombinant human thyroid-stimulating hormone (124)I PET/CT as implemented in this study precludes its use as a scouting procedure to prevent futile blind (131)I therapy., (© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.)

Published
2016
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48. [Robot-assisted transaxillary thyroid surgery].

Author

Vriens MR, Kist JW, Lodewijk L, van Hillegersberg R, and Borel Rinkes IH

Subjects
Axilla surgery, Humans, Learning Curve, Netherlands, Parathyroid Glands surgery, Robotics economics, Thyroid Gland surgery, Thyroidectomy economics, Robotics methods, Thyroid Neoplasms surgery, Thyroidectomy methods
Abstract

The robot-assisted transaxillary (hemi)thyroidectomy (RATT) is a new surgical technique using the da Vinci S surgery robot. This technique has recently been successfully introduced in the Netherlands. In a RATT a subcutaneous tunnel from the axilla is created to gain access to the thyroid gland. The operation is then carried out with the robot much like an open procedure. Using a RATT, a total thyroidectomy can be performed. However, surgeons at the beginning of the learning curve are advised to start with hemithyroidectomies only. The indication area consists of nodules up to three centimeters and most probably being benign. The major advantage of this technique is the prevention of a potentially disfiguring scar. The most important disadvantage of this technique is its high cost compared with the conventional procedure. In order to successfully introduce the RATT procedure, thorough preparation by both surgeons and operating room personnel is required. A proctoring program is also necessary.

Published
2013

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