26 results on '"Kissner M"'
Search Results
2. Resource utilization and productivity loss in persons with spina bifida − an observational study of patients in a tertiary urology clinic in Germany
- Author
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van Nooten, F. E., Winnette, R., Stein, R., Kissner, M., Schröder, A., Jöckel, M., Raluy-Callado, M., Lambrelli, D., Meinhardt, M., and Wasiak, R.
- Published
- 2015
- Full Text
- View/download PDF
3. Coherent backscattering of light
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Corey, R., Kissner, M., and Saulnier, P.
- Subjects
Backscattering -- Research ,Light scattering -- Analysis ,Physics - Abstract
Coherent backscattering of light (CBS) is a phenomenon in which partial waves traversing time-reversed (momentum-reversed) scattering paths interfere constructively in the backscattering direction leading to the appearance of an intensity cone. This increase in reflectivity reduces the amount of light transported through the colloidal media. As an advanced undergraduate laboratory CBS introduces the student to low-level light detection, precision angular resolved measurements, and sophisticated data analysis techniques. Additionally, the concept of photon self-interference, usually discussed in Modern Physics class in the context of Young's double slit experiment, is beautifully illustrated by CBS.
- Published
- 1995
4. Elevated carbohydrate deficient transferrin is a predictor of a prolonged intensive care unit stay in traumatized men
- Author
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Neumann, T., Kreutzer, T., Kißner, M., Schaffartzik, W., and Spies, C.
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- 1996
- Full Text
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5. Resource utilization and productivity loss in persons with spina bifida − an observational study of patients in a tertiary urology clinic in Germany
- Author
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van Nooten, F. E., primary, Winnette, R., additional, Stein, R., additional, Kissner, M., additional, Schröder, A., additional, Jöckel, M., additional, Raluy-Callado, M., additional, Lambrelli, D., additional, Meinhardt, M., additional, and Wasiak, R., additional
- Published
- 2014
- Full Text
- View/download PDF
6. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele
- Author
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Chen, L., primary, Faire, M., additional, Kissner, M. D., additional, and Laird, D. J., additional
- Published
- 2012
- Full Text
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7. miR-372/let-7 axis regulates human primordial germ cell specification
- Author
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Tran, N.D., primary, Kissner, M., additional, Laird, D., additional, and Blelloch, R., additional
- Published
- 2012
- Full Text
- View/download PDF
8. Lin28-let7-Blimp1 Circuitry regulates human primordial germ cells (hPGC) development from human embryonic stem cells (hESC)
- Author
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Tran, N.D., primary, Laird, D., additional, Kissner, M., additional, Conti, M., additional, and Blelloch, R., additional
- Published
- 2011
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9. Establishment and characterization of human germ cells derived from embryonic stem cells (hESCs)
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Tran, N.D., primary, Laird, D., additional, Kissner, M., additional, Supramanyam, D., additional, Conti, M., additional, and Blelloch, R., additional
- Published
- 2010
- Full Text
- View/download PDF
10. Transgene Independent Germ Cell Differentiation From Human Embryonic Stem Cells (hESCs)
- Author
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Tran, N.D., primary, Lair, D., additional, Kissner, M., additional, Conti, M., additional, and Blelloch, R., additional
- Published
- 2010
- Full Text
- View/download PDF
11. Resource utilization and productivity loss in persons with spina bifida − an observational study of patients in a tertiary urology clinic in Germany.
- Author
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Nooten, F. E., Winnette, R., Stein, R., Kissner, M., Schröder, A., Jöckel, M., Raluy ‐ Callado, M., Lambrelli, D., Meinhardt, M., and Wasiak, R.
- Subjects
SPINA bifida ,COGNITIVE ability ,SCIENTIFIC observation ,GENERAL practitioners ,HEALTH services accessibility ,HOSPITAL care - Abstract
Background and purpose To investigate resource use and burden associated with spina bifida ( SB) in Germany. Methods A questionnaire was used to obtain information on SB-related healthcare resource use and assistive technologies used for the last 1 and 10 years. Individuals with SB were recruited at a tertiary specialist clinic. To participate, persons with SB required the cognitive ability to respond or a caregiver to answer questions on their behalf. They could use personal medical charts or other records to answer. The analyses included assessment of frequency and extent of resource use for both time frames. Results Data on 88 persons with a diagnosis of SB were collected (44% female). During the last year, 88.6% ( N = 78) reported at least one visit to a general practitioner's ( GP's) office, 77.3% ( N = 68) to a urologist and 69.3% ( N = 61) to a physiotherapist. The annual average number of visits was 7.6 GP, 3.6 urologist and 65.3 physiotherapist visits. Amongst those hospitalized, a single hospitalization lasted 7.3 days on average, whereas the average annual number of hospital days was 14.8 days. During the previous 10 years, 67.0% ( N = 59) of responders used a wheelchair, 64.7% ( N = 57) used glasses and 59.1% ( N = 52) used orthopaedic shoes, with an average of 2.5, 2.8 and 6.1 new items used, respectively. Conclusions The results indicate that persons with SB require a substantial amount of interaction with healthcare providers, as well as other healthcare-related resource use, both in the shorter and longer terms. [ABSTRACT FROM AUTHOR]
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- 2015
- Full Text
- View/download PDF
12. ELEVATED CARBOHYDRATE-DEFICIENT TRANSFERRIN PREDICTS PROLONGED INTENSIVE CARE UNIT STAY IN TRAUMATIZED MEN
- Author
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SPIES, C. D., primary, KISSNER, M., additional, NEUMANN, T., additional, BLUM, S., additional, VOIGT, C., additional, FUNK, T., additional, RUNKEL, N., additional, and PRAGST, F., additional
- Published
- 1998
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13. Three-dimensional gray scale ultrasonographic imaging of the celiac axis: preliminary report.
- Author
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Spaulding, K A, primary, Kissner, M E, additional, Kim, E K, additional, Pretorius, D H, additional, Rose, S C, additional, Garroosi, K, additional, and Nelson, T R, additional
- Published
- 1998
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14. Putting the cardiovascular safety of aromatase inhibitors in patients with early breast cancer into perspective: a systematic review of the literature.
- Author
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Younus M, Kissner M, Reich L, Wallis N, Younus, Muhammad, Kissner, Michelle, Reich, Lester, and Wallis, Nicola
- Abstract
In the adjuvant setting, the third-generation aromatase inhibitors (AIs) anastrozole, letrozole and exemestane are recommended at some point during treatment, either in the upfront, switch after tamoxifen or extended treatment setting after tamoxifen in postmenopausal patients with hormone receptor-positive early breast cancer. AIs have demonstrated superior disease-free survival and overall benefit-to-risk profiles compared with tamoxifen. Potential adverse events, including cardiovascular (CV) side effects, should be considered in the long-term management of patients undergoing treatment with AIs. AIs reduce estrogen levels by inhibiting the aromatase enzyme, thus reducing the levels of circulating estrogen. This further reduction in estrogen levels may potentially increase the risk of developing CV disease. This systematic review evaluated published clinical data for changes in plasma lipoproteins and ischaemic CV events during adjuvant therapy with AIs in patients with hormone receptor-positive early breast cancer. The electronic databases MEDLINE, EMBASE, Derwent Drug File and BIOSIS were searched to identify English-language articles published from January 1998 to 15 April 2011 that reported data on AIs and plasma lipoproteins and/or ischaemic CV events. Overall, available data did not show any definitive patterns or suggest an unfavourable effect of AIs on plasma lipoproteins from baseline to follow-up assessment in patients with hormone receptor-positive early breast cancer. Changes that occurred in plasma lipoproteins were observed soon after initiation of AI therapy and generally remained stable throughout the studies. Available data do not support a substantial risk of ischaemic CV events associated with adjuvant AI therapy; however, studies with longer follow-up are required to better characterize the CV profile of AIs. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
15. Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States.
- Author
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Bashore AC, Xue C, Kim E, Yan H, Zhu LY, Pan H, Kissner M, Ross LS, Zhang H, Li M, and Reilly MP
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- Animals, Humans, Mice, Male, Mice, Inbred C57BL, Female, Transcriptome, Heart Disease Risk Factors, Middle Aged, Gene Expression Profiling methods, Monocytes metabolism, Monocytes immunology, Single-Cell Analysis methods, Cardiovascular Diseases immunology, Cardiovascular Diseases genetics, Cardiovascular Diseases metabolism
- Abstract
Background: Monocytes are a critical innate immune system cell type that serves homeostatic and immunoregulatory functions. They have been identified historically by the cell surface expression of CD14 and CD16. However, recent single-cell studies have revealed that they are much more heterogeneous than previously realized., Methods: We utilized cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) and single-cell RNA sequencing to describe the comprehensive transcriptional and phenotypic landscape of 437 126 monocytes., Results: This high-dimensional multimodal approach identified vast phenotypic diversity and functionally distinct subsets, including IFN-responsive, MHCII
hi (major histocompatibility complex class II), monocyte-platelet aggregates, as well as nonclassical, and several subpopulations of classical monocytes. Using flow cytometry, we validated the existence of MHCII+ CD275+ MHCIIhi , CD42b+ monocyte-platelet aggregates, CD16+ CD99- nonclassical monocytes, and CD99+ classical monocytes. Each subpopulation exhibited unique characteristics, developmental trajectories, transcriptional regulation, and tissue distribution. In addition, alterations associated with cardiovascular disease risk factors, including race, smoking, and hyperlipidemia were identified. Moreover, the effect of hyperlipidemia was recapitulated in mouse models of elevated cholesterol., Conclusions: This integrative and cross-species comparative analysis provides a new perspective on the comparison of alterations in monocytes in pathological conditions and offers insights into monocyte-driven mechanisms in cardiovascular disease and the potential for monocyte subpopulation targeted therapies., Competing Interests: None.- Published
- 2024
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16. High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.
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Bashore AC, Yan H, Xue C, Zhu LY, Kim E, Mawson T, Coronel J, Chung A, Sachs N, Ho S, Ross LS, Kissner M, Passegué E, Bauer RC, Maegdefessel L, Li M, and Reilly MP
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- Humans, Endothelial Cells metabolism, Epitopes metabolism, Myocytes, Smooth Muscle metabolism, Atherosclerosis pathology, Plaque, Atherosclerotic pathology, Carotid Artery Diseases pathology
- Abstract
Background: Atherosclerotic plaques are complex tissues composed of a heterogeneous mixture of cells. However, our understanding of the comprehensive transcriptional and phenotypic landscape of the cells within these lesions is limited., Methods: To characterize the landscape of human carotid atherosclerosis in greater detail, we combined cellular indexing of transcriptomes and epitopes by sequencing and single-cell RNA sequencing to classify all cell types within lesions (n=21; 13 symptomatic) to achieve a comprehensive multimodal understanding of the cellular identities of atherosclerosis and their association with clinical pathophysiology., Results: We identified 25 cell populations, each with a unique multiomic signature, including macrophages, T cells, NK (natural killer) cells, mast cells, B cells, plasma cells, neutrophils, dendritic cells, endothelial cells, fibroblasts, and smooth muscle cells (SMCs). Among the macrophages, we identified 2 proinflammatory subsets enriched in IL-1B (interleukin-1B) or C1Q expression, 2 TREM2-positive foam cells (1 expressing inflammatory genes), and subpopulations with a proliferative gene signature and SMC-specific gene signature with fibrotic pathways upregulated. Further characterization revealed various subsets of SMCs and fibroblasts, including SMC-derived foam cells. These foamy SMCs were localized in the deep intima of coronary atherosclerotic lesions. Utilizing cellular indexing of transcriptomes and epitopes by sequencing data, we developed a flow cytometry panel, using cell surface proteins CD29, CD142, and CD90, to isolate SMC-derived cells from lesions. Lastly, we observed reduced proportions of efferocytotic macrophages, classically activated endothelial cells, and contractile and modulated SMC-derived cells, while inflammatory SMCs were enriched in plaques of clinically symptomatic versus asymptomatic patients., Conclusions: Our multimodal atlas of cell populations within atherosclerosis provides novel insights into the diversity, phenotype, location, isolation, and clinical relevance of the unique cellular composition of human carotid atherosclerosis. These findings facilitate both the mapping of cardiovascular disease susceptibility loci to specific cell types and the identification of novel molecular and cellular therapeutic targets for the treatment of the disease., Competing Interests: Disclosures None.
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- 2024
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17. High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.
- Author
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Bashore AC, Yan H, Xue C, Zhu LY, Kim E, Mawson T, Coronel J, Chung A, Ho S, Ross LS, Kissner M, Passegué E, Bauer RC, Maegdefessel L, Li M, and Reilly MP
- Abstract
Background: Atherosclerotic plaques are complex tissues composed of a heterogeneous mixture of cells. However, we have limited understanding of the comprehensive transcriptional and phenotypical landscape of the cells within these lesions., Methods: To characterize the landscape of human carotid atherosclerosis in greater detail, we combined cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) and single-cell RNA sequencing (scRNA-seq) to classify all cell types within lesions (n=21; 13 symptomatic) to achieve a comprehensive multimodal understanding of the cellular identities of atherosclerosis and their association with clinical pathophysiology., Results: We identified 25 distinct cell populations each having a unique multi-omic signature, including macrophages, T cells, NK cells, mast cells, B cells, plasma cells, neutrophils, dendritic cells, endothelial cells, fibroblasts, and smooth muscle cells (SMCs). Within the macrophage populations, we identified 2 proinflammatory subsets that were enriched in IL1B or C1Q expression, 2 distinct TREM2 positive foam cell subsets, one of which also expressed inflammatory genes, as well as subpopulations displaying a proliferative gene expression signature and one expressing SMC-specific genes and upregulation of fibrotic pathways. An in-depth characterization uncovered several subsets of SMCs and fibroblasts, including a SMC-derived foam cell. We localized this foamy SMC to the deep intima of coronary atherosclerotic lesions. Using CITE-seq data, we also developed the first flow cytometry panel, using cell surface proteins CD29, CD142, and CD90, to isolate SMC-derived cells from lesions. Last, we found that the proportion of efferocytotic macrophages, classically activated endothelial cells, contractile and modulated SMC-derived cell types were reduced, and inflammatory SMCs were enriched in plaques of clinically symptomatic vs. asymptomatic patients., Conclusions: Our multimodal atlas of cell populations within atherosclerosis provides novel insights into the diversity, phenotype, location, isolation, and clinical relevance of the unique cellular composition of human carotid atherosclerosis. This facilitates both the mapping of cardiovascular disease susceptibility loci to specific cell types as well as the identification of novel molecular and cellular therapeutic targets for treatment of the disease.
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- 2023
- Full Text
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18. A comprehensive multiparameter flow cytometry panel for immune profiling and functional studies of frozen tissue, bone marrow, and spleen.
- Author
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Wu YC, Kissner M, and Momen-Heravi F
- Subjects
- Mice, Animals, Flow Cytometry, Monocytes, Immunophenotyping, Bone and Bones, Bone Marrow, Spleen
- Abstract
Flow cytometry (FC) is a highly informative technology that can provide valuable information about immune phenotype monitoring and immune cell states. However, there is a paucity of comprehensive panels developed and validated for use on frozen samples. Here, we developed a 17-plex flow cytometry panel to detect subtypes, frequencies, and functions of different immune cells that can be leveraged to study the different cellular characteristics in different disease models, physiological, and pathological conditions. This panel identifies surface markers to characterize T cells (CD8
+ , CD4+ ), natural killer (NK) cells and their subtypes (immature, cytotoxic, exhausted, activated),natural killer T (NKT) cells, neutrophils, macrophages (M1 (pro-inflammatory) and M2 (anti-inflammatory)), monocytes and their subtypes (classical and non-classical), dendritic cells (DC) and their subtypes (DC1, DC2), and eosinophils. The panel was designed to include only surface markers to avoid the necessity for fixation and permeabilization steps. This panel was optimized using cryopreserved cells. Immunophenotyping of spleen and bone marrow using the proposed panel was efficient in correctly differentiating the immune cell subtypes in inflammatory model of ligature-induced periodontitis, in which we found increased percentage of NKT cells, activated and mature/cytotoxic NK cells in the bone marrow of affected mice. This panel enables in-depth immunophenotyping of murine immune cells in bone marrow, spleen, tumors, and other non-immune tissues of mice. It could be a tool for systematic analysis of immune cell profiling in inflammatory conditions, systemic diseases, and tumor microenvironments., Competing Interests: Declaration of Competing Interest The authors disclosed no conflict of interests., (Copyright © 2023. Published by Elsevier B.V.)- Published
- 2023
- Full Text
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19. Management of Chronic Subdural Hematoma: A Systematic Review and Component Network Meta-analysis of 455 Studies With 103 645 Cases.
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Henry J, Amoo M, Kissner M, Deane T, Zilani G, Crockett MT, and Javadpour M
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- Humans, Network Meta-Analysis, Treatment Outcome, Meningeal Arteries, Subdural Space, Drainage, Hematoma, Subdural, Chronic surgery
- Abstract
Background: Chronic subdural hematoma (CSDH) is a common neurosurgical condition with a high risk of recurrence after treatment., Objective: To assess and compare the risk of recurrence, morbidity, and mortality across various treatments for CSDH., Methods: A systematic review and meta-analysis was performed. PubMed/MEDLINE, EMBASE, SCOPUS, and Web of Science were searched from January 01, 2000, to July 07, 2021. The primary outcome was recurrence, and secondary outcomes were morbidity and mortality. Component network meta-analyses (CNMAs) were performed for surgical and medical treatments, assessing recurrence and morbidity. Incremental risk ratios (iRRs) with 95% CIs were estimated for each component., Results: In total, 12 526 citations were identified, and 455 studies with 103 645 cases were included. Recurrence occurred in 11 491/93 525 (10.8%, 95% CI 10.2-11.5, 418 studies) cases after surgery. The use of a postoperative drain (iRR 0.53, 95% CI 0.44-0.63) and middle meningeal artery embolization (iRR 0.19, 95% CI 0.05-0.83) reduced recurrence in the surgical CNMA. In the pharmacological CNMA, corticosteroids (iRR 0.47, 95% CI 0.36-0.61) and surgical intervention (iRR 0.11, 95% CI 0.07-0.15) were associated with lower risk. Corticosteroids were associated with increased morbidity (iRR 1.34, 95% CI 1.05-1.70). The risk of morbidity was equivalent across surgical treatments., Conclusion: Recurrence after evacuation occurs in approximately 10% of cSDHs, and the various surgical interventions are approximately equivalent. Corticosteroids are associated with reduced recurrence but also increased morbidity. Drains reduce the risk of recurrence, but the position of drain (subdural vs subgaleal) did not influence recurrence. Middle meningeal artery embolization is a promising treatment warranting further evaluation in randomized trials., (Copyright © Congress of Neurological Surgeons 2022. All rights reserved.)
- Published
- 2022
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20. Evaluating the Combined Anticancer Response of Checkpoint Inhibitor Immunotherapy and FAP-Targeted Molecular Radiotherapy in Murine Models of Melanoma and Lung Cancer.
- Author
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Capaccione KM, Doubrovin M, Braumuller B, Leibowitz D, Bhatt N, Momen-Heravi F, Molotkov A, Kissner M, Goldner K, Soffing M, Ali A, and Mintz A
- Abstract
Immunotherapy has dramatically improved outcomes for some cancer patients; however, novel treatments are needed for more patients to achieve a long-lasting response. FAP-targeted molecular radiotherapy has shown efficacy in both preclinical and clinical models and has immunomodulatory effects. Here, we studied if combined immunotherapy and radiotherapy could increase antitumor efficacy in murine models of lung cancer and melanoma and interrogated the mechanisms by which these treatments attenuate tumor growth. Using LLC1 and B16F10 murine models of lung cancer and melanoma, respectively, we tested the efficacy of
177 Lu-FAPI-04 alone and in combination with immunotherapy. Alone,177 Lu-FAPI-04 significantly reduced tumor growth in both models. In animals with melanoma, combined therapy resulted in tumor regression while lung tumor growth was attenuated, but tumors did not regress. Combined therapy significantly increased caspase-3 and decreased Ki67 compared with immunotherapy alone. Flow cytometry demonstrated that tumor-associated macrophages responded in a tumor-dependent manner which was distinct in animals treated with both therapies compared with either therapy alone. These data demonstrate that177 Lu-FAPI-04 is an effective anticancer therapy for melanoma and lung cancer which mediates effects at least partially through induction of apoptosis and modulation of the immune response. Translational studies with immunotherapy and177 Lu-FAPI-04 are needed to demonstrate the clinical efficacy of this combined regimen.- Published
- 2022
- Full Text
- View/download PDF
21. A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates.
- Author
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Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, and Blelloch RH
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- Biomarkers metabolism, Humans, MicroRNAs genetics, Cell Lineage, Germ Cells cytology, Germ Cells metabolism, MicroRNAs metabolism, Signal Transduction genetics
- Abstract
The embryonic stem cell cycle (ESCC) and let-7 families of miRNAs function antagonistically in the switch between mouse embryonic stem cell self-renewal and somatic differentiation. Here, we report that the human ESCC miRNA miR-372 and let-7 act antagonistically in germline differentiation from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs). hESC and iPSC-derived primordial germ cell-like cells (PGCLCs) expressed high levels of miR-372 and conversely, somatic cells expressed high levels of let-7. Manipulation of miRNA levels by introduction of miRNA mimics or knockdown with miRNA sponges demonstrated that miR-372 promotes whereas let-7 antagonizes PGCLC differentiation. Knockdown of the individual miR-372 targets SMARCC1, MECP2, CDKN1, RBL2, RHOC, and TGFBR2 increased PGCLC production, whereas knockdown of the let-7 targets CMYC and NMYC suppressed PGCLC differentiation. These findings uncover a miR-372/let-7 axis regulating human primordial germ cell (PGC) specification. Stem Cells 2016;34:1985-1991., (© 2016 AlphaMed Press.)
- Published
- 2016
- Full Text
- View/download PDF
22. Resource utilization and productivity loss in persons with spina bifida—an observational study of patients in a tertiary urology clinic in Germany.
- Author
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van Nooten FE, Winnette R, Stein R, Kissner M, Schröder A, Jöckel M, Raluy-Callado M, Lambrelli D, Meinhardt M, and Wasiak R
- Subjects
- Adult, Female, Germany, Humans, Male, Tertiary Care Centers, Cost of Illness, Health Services statistics & numerical data, Hospitalization statistics & numerical data, Self-Help Devices statistics & numerical data, Spinal Dysraphism rehabilitation
- Abstract
Background and Purpose: To investigate resource use and burden associated with spina bifida (SB) in Germany., Methods: A questionnaire was used to obtain information on SB-related healthcare resource use and assistive technologies used for the last 1 and 10 years. Individuals with SB were recruited at a tertiary specialist clinic. To participate, persons with SB required the cognitive ability to respond or a caregiver to answer questions on their behalf. They could use personal medical charts or other records to answer. The analyses included assessment of frequency and extent of resource use for both time frames., Results: Data on 88 persons with a diagnosis of SB were collected (44% female). During the last year, 88.6% (N = 78) reported at least one visit to a general practitioner's (GP's) office, 77.3% (N = 68) to a urologist and 69.3% (N = 61) to a physiotherapist. The annual average number of visits was 7.6 GP, 3.6 urologist and 65.3 physiotherapist visits. Amongst those hospitalized, a single hospitalization lasted 7.3 days on average, whereas the average annual number of hospital days was 14.8 days. During the previous 10 years, 67.0% (N = 59) of responders used a wheelchair, 64.7% (N = 57) used glasses and 59.1% (N = 52) used orthopaedic shoes, with an average of 2.5, 2.8 and 6.1 new items used, respectively., Conclusions: The results indicate that persons with SB require a substantial amount of interaction with healthcare providers, as well as other healthcare-related resource use, both in the shorter and longer terms., (© 2014 EAN.)
- Published
- 2015
- Full Text
- View/download PDF
23. Health-related quality of life is compromised in individuals with spina bifida: results from qualitative and quantitative studies.
- Author
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Rofail D, Maguire L, Kissner M, Colligs A, and Abetz-Webb L
- Subjects
- Emotions, Humans, Mental Health, Pain etiology, Qualitative Research, Self Concept, Severity of Illness Index, Social Participation, Spinal Dysraphism prevention & control, Health Status, Quality of Life, Spinal Dysraphism complications, Spinal Dysraphism psychology
- Abstract
Spina bifida (SB) accounts for approximately 90% of total neural tube defects. According to the degree of SB severity, the range of associated symptoms and complications varies greatly. Given the complexity and diversity of these complications, individuals with SB might suffer from livelong impairment. This review presents an overview of the impact of SB on patients' health-related quality of life (HRQoL) and explores results from published quantitative and qualitative studies regarding the HRQoL impact of SB on patients, as well as comparing results of existing studies to national norms. A literature search using three electronic databases PUBMED, PsycINFO, and Embase was performed to identify relevant studies dating from January 1976 to November 2010. To satisfy the initial inclusion criteria, articles had to contain studies that were specific to HRQoL in patients with SB. Findings highlight that HRQoL is significantly impaired in patients with SB. Making sure that the public is aware of the disease and how to minimise the risk of NTD, such as SB (e.g., through adequate folate levels at time of conception, etc.) is essential to ensure that fewer individuals face the burden of NTDs in the future., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
24. A review of the social, psychological, and economic burdens experienced by people with spina bifida and their caregivers.
- Author
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Rofail D, Maguire L, Kissner M, Colligs A, and Abetz-Webb L
- Abstract
Introduction: Despite measures to reduce the incidence of neural tube defects (NTDs), the rate of decline has not been as dramatic as expected. At least 300,000 newborns worldwide are known to be affected by NTDs each year. This comprehensive literature review summarizes the human and economic burden of NTDs to patients and caregivers, with particular focus on spina bifida (SB)., Methods: PubMed, PsycINFO, and Embase were searched for studies from January 1976 to November 2010 that included clinical terms, such as NTD, and at least one patient-reported outcome or cost term. A conceptual model was also developed., Results: Areas of peoples' lives affected by SB included physical and role functioning, activities of daily living, bodily pain, vitality, emotional functioning, mental health, self-esteem, self-image, social functioning, relationships, and sexual functioning. Areas of caregivers' lives affected included activities of daily living, work impact, time consumption, parental responsibilities (including responsibilities to other children), confidence, feelings and emotions, mental health, stress, social impact, psychological adjustment, relationships (with SB child, siblings, other family members), social support, coping strategies, and termination decisions. Cost burdens on patients and caregivers also include out-of-pocket costs, lost wages, or household production due to increased morbidity and mortality, transportation and other nonmedical costs., Conclusions: This review highlights the need to provide care and support to individuals with SB and their caregivers. Results also emphasize the importance of effective long-term public health campaigns and/or newer strategies to prevent NTDs, such as SB.
- Published
- 2013
- Full Text
- View/download PDF
25. Aromatase inhibitor therapy: toxicities and management strategies in the treatment of postmenopausal women with hormone-sensitive early breast cancer.
- Author
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Dent SF, Gaspo R, Kissner M, and Pritchard KI
- Subjects
- Aromatase Inhibitors adverse effects, Arthralgia chemically induced, Bone Diseases, Metabolic chemically induced, Cardiovascular Diseases chemically induced, Chemotherapy, Adjuvant, Clinical Trials as Topic, Cognition Disorders chemically induced, Disease Management, Female, Genital Diseases, Female chemically induced, Hot Flashes chemically induced, Humans, Postmenopause, Aromatase Inhibitors therapeutic use, Breast Neoplasms drug therapy
- Abstract
Aromatase inhibitors (AIs) have been shown to reduce the risk of breast cancer recurrence and are widely used today as adjuvant therapy in women with early stage endocrine-responsive breast cancer. Aromatase inhibitors may be prescribed as initial hormonal therapy, sequentially following 2-3 years of tamoxifen, or as extended adjuvant therapy (following 5 years of tamoxifen). Aromatase inhibitors are generally well tolerated; however, certain side effects, particularly arthralgia/musculoskeletal symptoms and gynecologic effects, may result in poor adherence to treatment. Patients receiving adjuvant therapy with an AI should be counseled regarding possible side effects and the importance of completing treatment. Interventions to ameliorate side effects should be individualized based on symptoms, comorbid conditions, and pre-existing therapies. In addition, bone and cardiovascular health should be monitored during AI therapy. Prompt therapeutic management of common side effects associated with AIs may provide patients with the opportunity to receive the full benefit of their adjuvant hormonal treatment while minimizing toxicity.
- Published
- 2011
- Full Text
- View/download PDF
26. Double formula room.
- Author
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KISSNER M
- Subjects
- Humans, Hospitals
- Published
- 1955
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