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45 results on '"Kisslinger Annamaria"'

1. The Role of Metaphor in Serious Games Design: the BubbleMumble Case Study

Author

Allegra, Mario, Bongiovanni, Antonella, Città, Giuseppe, Cusimano, Antonella, Dal Grande, Valentina, Gentile, Manuel, Kisslinger, Annamaria, La Guardia, Dario, Liguori, Giovanna, Lo Presti, Fabrizio, Perna, Salvatore, Picciotto, Sabrina, Ottaviano, Simona, Sala, Carla, Signa, Alessandro, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, de Rosa, Francesca, editor, Marfisi Schottman, Iza, editor, Baalsrud Hauge, Jannicke, editor, Bellotti, Francesco, editor, Dondio, Pierpaolo, editor, and Romero, Margarida, editor

Published
2021
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8. A Novel Localization in Human Large Extracellular Vesicles for the EGF-CFC Founder Member CRIPTO and Its Biological and Therapeutic Implications

Author

Mantile, Francesca, primary, Kisovec, Matic, additional, Adamo, Giorgia, additional, Romancino, Daniele P., additional, Hočevar, Matej, additional, Božič, Darja, additional, Bedina Zavec, Apolonija, additional, Podobnik, Marjetka, additional, Stoppelli, Maria Patrizia, additional, Kisslinger, Annamaria, additional, Bongiovanni, Antonella, additional, Kralj-Iglič, Veronika, additional, and Liguori, Giovanna L., additional

Published
2022
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12. Nanoalgosomes: Introducing extracellular vesicles produced by microalgae

Author

Adamo, Giorgia, primary, Fierli, David, additional, Romancino, Daniele P., additional, Picciotto, Sabrina, additional, Barone, Maria E., additional, Aranyos, Anita, additional, Božič, Darja, additional, Morsbach, Svenja, additional, Raccosta, Samuele, additional, Stanly, Christopher, additional, Paganini, Carolina, additional, Gai, Meiyu, additional, Cusimano, Antonella, additional, Martorana, Vincenzo, additional, Noto, Rosina, additional, Carrotta, Rita, additional, Librizzi, Fabio, additional, Randazzo, Loredana, additional, Parkes, Rachel, additional, Capasso Palmiero, Umberto, additional, Rao, Estella, additional, Paterna, Angela, additional, Santonicola, Pamela, additional, Iglič, Ales, additional, Corcuera, Laura, additional, Kisslinger, Annamaria, additional, Schiavi, Elia Di, additional, Liguori, Giovanna L., additional, Landfester, Katharina, additional, Kralj‐Iglič, Veronika, additional, Arosio, Paolo, additional, Pocsfalvi, Gabriella, additional, Touzet, Nicolas, additional, Manno, Mauro, additional, and Bongiovanni, Antonella, additional

Published
2021
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14. Isolation of extracellular vesicles from microalgae: towards the production of sustainable and natural nanocarriers of bioactive compounds

Author

Picciotto, Sabrina, primary, Barone, Maria E., additional, Fierli, David, additional, Aranyos, Anita, additional, Adamo, Giorgia, additional, Božič, Darja, additional, Romancino, Daniele P., additional, Stanly, Christopher, additional, Parkes, Rachel, additional, Morsbach, Svenja, additional, Raccosta, Samuele, additional, Paganini, Carolina, additional, Cusimano, Antonella, additional, Martorana, Vincenzo, additional, Noto, Rosina, additional, Carrotta, Rita, additional, Librizzi, Fabio, additional, Capasso Palmiero, Umberto, additional, Santonicola, Pamela, additional, Iglič, Ales, additional, Gai, Meiyu, additional, Corcuera, Laura, additional, Kisslinger, Annamaria, additional, Di Schiavi, Elia, additional, Landfester, Katharina, additional, Liguori, Giovanna L., additional, Kralj-Iglič, Veronika, additional, Arosio, Paolo, additional, Pocsfalvi, Gabriella, additional, Manno, Mauro, additional, Touzet, Nicolas, additional, and Bongiovanni, Antonella, additional

Published
2021
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22. The qPMO network: quality management tools to improve research efficiency, reproducibility, data management and dissemination

Author

Bongiovanni, Antonella, primary, Liguori, Giovanna Lucia, additional, Colotti, Gianni, additional, Cirafici, Anna Maria, additional, Di Carlo, Marta, additional, Digilio, Filomena Anna, additional, Lacerra, Giuseppina, additional, Lanati, Antonella, additional, Mascia, Anna, additional, and Kisslinger, Annamaria, additional

Published
2016
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23. Convergent Effects of Resveratrol and PYK2 on Prostate Cells

Author

Conte, Andrea, primary, Kisslinger, Annamaria, additional, Procaccini, Claudio, additional, Paladino, Simona, additional, Oliviero, Olimpia, additional, de Amicis, Francesca, additional, Faicchia, Deriggio, additional, Fasano, Dominga, additional, Caputo, Marilena, additional, Matarese, Giuseppe, additional, Pierantoni, Giovanna, additional, and Tramontano, Donatella, additional

Published
2016
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35. Comparison of the photoactivation efficacy of two chlorin derivatives

Author

Colasanti, Alberto, primary, Kisslinger, Annamaria, additional, Kusch, Dirk, additional, Liuzzi, Raffaele, additional, Mastrocinque, Michele, additional, Montforts, Franz-Peter, additional, Quarto, Maria, additional, Riccio, Patrizia, additional, Roberti, Giuseppe, additional, and Villani, Fulvia, additional

Published
1996
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40. Comparison of the photoactivation efficacy of two chlorin derivatives

Author

Colasanti, Alberto, Kisslinger, Annamaria, Kusch, Dirk, raffaele liuzzi, Mastrocinque, Michele, Montforts, Franz-Peter, Quarto, M., Riccio, P., Roberti, Giuseppe, and Villani, F.

Subjects
polycyclic compounds
Abstract

We investigated the in vitro photoactivation properties of two chlorin derivatives, 8-cis-heptylchlorin dicarboxylic acid and 3-trans-heptylchlorin bisamidoglucose derivative, that exhibit a very strong absorbance peak in the red region of the spectrum and a value of the extinction coefficient (at the wavelength of the maximum absorbance) higher by one order of magnitude than the corresponding value for the porphyrins. The experiments of photoactivation were performed on a normal epithelial cell line (FRTL-5), using as an irradiation source an array of diodes emitting red light (lambda equals 675 nm). We found that, in the concentration range of 1 to 3000 ng/ml, photoactivation of chlorins greatly enhanced mortality of drug exposed irradiated cells (density of energy equals 0.25 mJ/cm2) with respect to the ones exposed to the drug but kept in the dark. This response is immediate and it looks line an 'all or none' effect. The comparison between the extinction coefficient and the efficacy of photoactivation of the two chlorin derivatives seems to indicate that they have similar values of the photophysical and photochemical quantities characterizing the processes responsible of the generation of singlet oxygen, the reactive species to whom the photoinduced toxicity of chlorins was generally imputed.

41. Quantitative analysis of anthracyclines kinetics in cells varying in drug responsiveness

Author

Colasanti, Alberto, Kisslinger, Annamaria, Liuzzi, R., Mastrocinque, Michele, Quarto, M., Riccio, P., Roberti, Giuseppe, FULVIA VILLANI, S. B. Brown, B. Ehrenberg, J. Moan, Colasanti, A., Kisslinger, A., Liuzzi, R., Mastrocinque, M., Quarto, Maria, Riccio, Patrizia, Roberti, G., and Villani, F.

Subjects
photoactivation, fluorimetric technique, LoVo/DC cell
Abstract

A fluorimetric technique to measure transport parameters of fluorescent drugs through cellular membranes is described. This method eliminates procedures that would lead to errors in the measurement of drug accumulated by cells, and measures the fraction of free drug in cells. The use of a simple three-compartment model in conjunction with fluorescence measurements performed on the extracellular medium and on Triton-permeabilized cells at different times during daunorubicin incorporation allows determination of the kinetic parameters of the transport through cellular membranes. With this technique we found that LoVo cells have a greater daunorubicin uptake, a similar input rate constant and a lower output rate constant than the drug resistant LoVo/DX cells. Preliminary photoactivation measurements of these two cell lines with these compounds showed that phototoxic effects are related to the amount of drug bound to cellular sites.

43. The Impact of Social and Cultural Engagement and Dieting on Well-Being and Resilience in a Group of Residents in the Metropolitan Area of Naples

Author

Antonio Rapacciuolo, 1 Pasquale Perrone Filardi, 1 Rosario Cuomo, 2 Vincenzo Mauriello, 3 Maria Quarto, 4 Annamaria Kisslinger, 5, 6 Gianluigi Savarese, 1 Maddalena Illario, 7, 8, Donatella Tramontano6, 9, Rapacciuolo, Antonio, PERRONE FILARDI, Pasquale, Cuomo, Rosario, Mauriello, Vincenzo, Quarto, Maria, Kisslinger, Annamaria, Savarese, Gianluigi, Illario, Maddalena, and Tramontano, Donatella

Subjects
Gerontology, Isolation (health care), Article Subject, media_common.quotation_subject, 050109 social psychology, lcsh:Geriatrics, 03 medical and health sciences, 0302 clinical medicine, well-being, Medicine, 0501 psychology and cognitive sciences, 030212 general & internal medicine, Social isolation, resilience, media_common, business.industry, 05 social sciences, aging, medicine.disease, Metropolitan area, Regimen, Malnutrition, lcsh:RC952-954.6, Well-being, Psychological resilience, medicine.symptom, Geriatrics and Gerontology, business, Dieting, Research Article
Abstract

Social isolation and exclusion are associated with poor health status and premature death. A number of related isolation factors, inadequate transportation system and restrictions in individuals’ life space, have been associated with malnutrition in older adults. Since eating is a social event, isolation can have a negative effect on nutrition. Cultural involvement and participation in interactive activities are essential tools to fight social isolation, and they can counteract the detrimental effects of social isolation on health. To provide data supporting the hypothesis that encouraging participation might represent an innovative preventive and health promoting strategy for healthy living and aging, we developed anad hocquestionnaire to investigate the relationship between cultural participation, well-being, and resilience in a sample of residents in the metropolitan area of Naples. The questionnaire includes a question on adherence to diet or to a special nutritional regimen; in addition, the participants are asked to mention their height and weight. We investigated the relationship between BMI, adherence to diet, and perceived well-being (PWB) and resilience in a sample of 571 subjects over 60 years of age. Here, we present evidence that engagement into social and cultural activities is associated with higher well-being and resilience, in particular in females over 60 years of age.

Published
2016
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44. Combined effects of radiotherapy and photodynamic therapy on an in vitro human prostate model.

Author

Colasanti A, Kisslinger A, Quarto M, and Riccio P

Subjects
Cell Line, Cell Line, Tumor, Cell Survival, Combined Modality Therapy, Humans, Indocyanine Green metabolism, Male, Prostate cytology, Prostate radiation effects, Prostatic Neoplasms drug therapy, Prostatic Neoplasms radiotherapy, Indocyanine Green therapeutic use, Photochemotherapy, Prostatic Neoplasms therapy
Abstract

Human prostate cancer cells were evaluated for growth after photodynamic therapy, radiotherapy, and combined treatment. Indocyanine green was tested as a photosensitizer and radiosensitizer. Two human cell lines were used: PC-3 derived from prostate carcinoma, and EPN derived from normal prostate tissue. The light source used for the photoactivation experiments was a diode laser peaked at 805 nm. The light dose incident on cells was 108 J/cm(2). Ionizing radiation was produced by a linear accelerator, and the dose was 2, 4 and 6 Gy. Cytotoxicity was evaluated by measuring the colony forming ability of cells. Our results show that indocyanine green induces cell death by photoactivation, but it does not act as a radiosensitizer if used with ionizing radiation. The combined treatment of photodynamic therapy and radiotherapy produces an additive effect which does not depend on the sequence of the two treatments. Combined treatments could be more useful since they allow the reduction of the ionizing radiation dose to obtain the same effect as one obtainable by radiotherapy alone.

Published
2004

45. 17beta-estradiol-induced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor alpha-Src complex in human prostate cells.

Author

Chieffi P, Kisslinger A, Sinisi AA, Abbondanza C, and Tramontano D

Subjects
Blotting, Western, Cell Division, Cell Line, Cell Line, Tumor, Enzyme Activation, Enzyme Inhibitors pharmacology, Flavonoids pharmacology, Humans, Male, Microscopy, Fluorescence, Mitogen-Activated Protein Kinase 3, Precipitin Tests, Prostate metabolism, Prostatic Neoplasms metabolism, Protein Isoforms, Protein Structure, Tertiary, Time Factors, Estradiol metabolism, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinases metabolism, Prostatic Neoplasms pathology, Receptors, Androgen metabolism, Receptors, Estradiol metabolism, src-Family Kinases metabolism
Abstract

We examined the effect of estrogens on mitogen-activated protein kinase (MAPK) in EPN cells, a line of epithelial cells derived from human normal prostate. 17beta-estradiol (E2) caused a rapid and transient activation of MAPK (ERK1/2) within 5 min. This effect was counteracted by the anti-estrogen ICI 182-780 and by MEK inhibitor PD098059. The activation of ERK1/2 through 17beta-estradiol triggered simultaneous association of endogenous androgen receptor, estrogen receptor alpha and Src. In addition, E2 stimulated the proliferation of EPN cells, suggesting that the formation of the ternary complex and the consequent activation of ERKs are implicated in the mechanism regulating proliferation of epithelial prostate cells.

Published
2003

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