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117 results on '"Kishi, Kazuhiro"'

3. Cerebral Microbleeds, Cerebrospinal Fluid, and Neuroimaging Markers in Clinical Subtypes of Alzheimer's Disease

Author

Ikeda, Masaki, primary, Kodaira, Sayaka, additional, Kasahara, Hiroo, additional, Takai, Eriko, additional, Nagashima, Kazuaki, additional, Fujita, Yukio, additional, Makioka, Kouki, additional, Hirayanagi, Kimitoshi, additional, Furuta, Natsumi, additional, Furuta, Minori, additional, Sanada, Etsuko, additional, Kobayashi, Ayumi, additional, Harigaya, Yasuo, additional, Nagamine, Shun, additional, Hattori, Noriaki, additional, Tashiro, Yuichi, additional, Kishi, Kazuhiro, additional, Shimada, Hirotaka, additional, Suto, Takayuki, additional, Tanaka, Hisashi, additional, Sakai, Yasujiro, additional, Yamazaki, Tsuneo, additional, Tanaka, Yukiko, additional, Aihara, Yuko, additional, Amari, Masakuni, additional, Yamaguchi, Haruyasu, additional, Okamoto, Koichi, additional, Takatama, Masamitsu, additional, Ishii, Kenji, additional, Higuchi, Tetsuya, additional, Tsushima, Yoshito, additional, and Ikeda, Yoshio, additional

Published
2021
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7. Sucrase-isomaltase and hexose transporter gene expressions are coordinately enhanced by dietary fructose in rat jejunum

Author

Kishi, Kazuhiro, Tanaka, Takemi, Igawa, Makiko, Takase, Sachiko, and Goda, Toshinao

Subjects
Gene expression -- Research, Fructose -- Genetic aspects, Rats -- Genetic aspects, Jejunum -- Genetic aspects, Food/cooking/nutrition
Abstract

We previously demonstrated that the levels of mRNAs of both sucrase-isomaltase (SI) and sodium/D-glucose transporter (SGLT1) are modulated by dietary sucrose in the rat jejunum. In the present study, we investigated whether the transcription of the gene coding SI is regulated by certain types of monosaccharides. Force-feeding a fructose and sucrose diet, (40% energy as fructose or sucrose) gave rise to parallel increases in the transcripts of SI and intestinal hexose transporters (SGLT1, GLUT5, and GLUT2) within 12 h. Force-feeding a glycerol-containing diet also caused an enhancement of SI, SGLT1, and GLUT2 mRNA levels. However, feeding the diet containing glucose or [Alpha]-methylglucoside generally did not increase the transcript levels of SI or the intestinal hexose transporters. Nuclear run-on assays revealed that fructose as well as sucrose increased the transcription of both SI and GLUT5 genes and that the transcription rates of these genes were unaffected by glucose. These results suggest that fructose (or a metabolite) is capable of increasing the mRNA levels of SI and hexose transporters in the small intestine and that transcriptional regulation might play a pivotal role in the carbohydrate-induced coordinate enhancement of SI and fructose transporter gene expression. KEY WORDS: sucrase-isomaltase; gene expression; fructose; hexose transporters; rats

Published
1999

8. The maltitol-induced increase in intestinal calcium transport increases the calcium content and breaking force of femoral bone in weanling rats

Author

Goda, Toshinao, Kishi, Kazuhiro, Ezawa, Ikuko, and Takase, Sachiko

Subjects
Rats -- Physiological aspects, Calcium -- Physiological aspects, Calcium in animal nutrition -- Research, Intestinal absorption -- Research, Bones -- Physiological aspects, Food/cooking/nutrition
Abstract

Maltitol is a disaccharide alcohol that is produced by hydrogenation of maltose and exhibits resistance to intestinal disaccharidases. We demonstrated previously that maltitol stimulated transepithelial diffusional calcium transfer in the ileum, accompanied by an elevation of intestinal calcium absorption as well as calcium retention in the body. In this study we examined whether the maltitol-induced increase in the diffusional transfer of intestinal calcium absorption leads to an alteration of the physical properties of bones in the weanling rats which exhibit the maximal level of intestinal active calcium absorption. Rat pups were removed from dams at 24 d of age and were fed the diets containing either maltose (control) or maltitol and a requisite amount of calcium (0.52%) for 21 d. Balance studies performed during the final 5-d period showed that maltitol-fed rats had greater calcium retention and calcium absorption. The breaking force of femoral bones was 13% greater in the rats fed the maltitol diet than in controls. The calcium content and dry weight of both femurs and tibias, as well as the bone mineral density of tibias, were elevated in the rats fed the maltitol diet. In a separate experiment, gastric intubation of maltitol-containing diet increased the serum calcium concentration in the portal vein at 2 and 4 h compared to controls. These results indicate that the maltitol-induced increase in the intestinal calcium absorption through paracellular pathway leads to enhancement of the calcium content and the breaking strength in the bone of weanling rats. KEY WORDS: * calcium * maltitol * intestinal absorption * bone * rats

Published
1998

10. Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice

Author

Minami, Asako, Iseki, Masanori, Kishi, Kazuhiro, Wang, Miao, Ogura, Makoto, Furukawa, Noboru, Hayashi, Sanae, Yamada, Mizuki, Obata, Toshiyuki, Takeshita, Yukari, Nakaya, Yutaka, Bando, Yoshimi, Izumi, Keisuke, Moodie, Shonna A., Kajiura, Fumiko, Matsumoto, Mitsuru, Takatsu, Kiyoshi, Takaki, Satoshi, and Ebina, Yousuke

Published
2003

11. Deep White Matter Lesions Are Associated with Early Recognition of Dementia in Alzheimer’s Disease

Author

Kasahara, Hiroo, primary, Ikeda, Masaki, additional, Nagashima, Kazuaki, additional, Fujita, Yukio, additional, Makioka, Kouki, additional, Tsukagoshi, Setsuki, additional, Yamazaki, Tsuneo, additional, Takai, Eriko, additional, Sanada, Etsuko, additional, Kobayashi, Ayumi, additional, Kishi, Kazuhiro, additional, Suto, Takayuki, additional, Higuchi, Tetsuya, additional, Tsushima, Yoshito, additional, and Ikeda, Yoshio, additional

Published
2019
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13. Bradykinin directly triggers GLUT4 translocation via an insulin-dependent pathway

Author

Kishi, Kazuhiro, Muromoto, Naoko, Nakaya, Yutaka, Miyata, Ikuko, Hagi, Akifumo, Hayashi, Hideki, and Ebina, Yousuke

Subjects
Metabolic regulation -- Physiological aspects, Exercise -- Physiological aspects, Bradykinin -- Physiological aspects, Gluconeogenesis -- Physiological aspects, Health, Physiological aspects
Abstract

Physical exercise induces translocation of GLUT4 from an intracellular pool to the cell surface in skeletal muscles and increases glucose uptake via an insulin-independent pathway. However, the molecular mechanism remains [...]

Published
1998

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Author

Hayashi, Junji, Kishi, Kazuhiro, Akada, Ayu, Imai, Nagomi, Udaka, Soshiro, Kawasaki, Sena, Shinohara, Ryota, Tainaka, Kazuki, Takada, Marina, Murachi, Shin, Yamaoka, Shunsuke, Hayashi, Junji, Kishi, Kazuhiro, Akada, Ayu, Imai, Nagomi, Udaka, Soshiro, Kawasaki, Sena, Shinohara, Ryota, Tainaka, Kazuki, Takada, Marina, Murachi, Shin, and Yamaoka, Shunsuke

Published
2018

17. Paraneoplastic Hypocalcemia Developed in Gastric Cancer Accompanied by Osteoblastic Metastasis

Author

Okazaki, Jun, Muguruma, Naoki, Kitamura, Shinji, Kimura, Tetsuo, Okamoto, Koichi, Miyamoto, Hiroshi, Kishi, Kazuhiro, Bando, Yoshimi, Kondo, Takeshi, Endo, Itsuro, Abe, Masahiro, Takayama, Tetsuji, Okazaki, Jun, Muguruma, Naoki, Kitamura, Shinji, Kimura, Tetsuo, Okamoto, Koichi, Miyamoto, Hiroshi, Kishi, Kazuhiro, Bando, Yoshimi, Kondo, Takeshi, Endo, Itsuro, Abe, Masahiro, and Takayama, Tetsuji

Abstract

Paraneoplastic syndromes are generally defined as clinical disorders associated with malignant diseases, and hypocalcemia associated with cancer is a rare condition. A woman in her 60s was referred to our hospital for the further examination of massive ascites due to carcinoma of unknown primary origin. She complained of numbness around her lips, and marked hypocalcemia of 5.0 mg/dL was noted. After two courses of chemotherapy, computed tomography showed a decrease in the ascites, and her serum calcium level increased. Although hypocalcemia is a very rare condition in patients with gastric cancer, serum calcium values should be evaluated when neurological symptoms are observed.

Published
2017

19. Poly-(ADP-Ribose) Polymerase-1 Promotes Prothrombin Gene Transcription and Produces Des-Gamma-Carboxy Prothrombin in Hepatocellular Carcinoma

Author

Taniguchi, Tatsuya, primary, Kishi, Kazuhiro, additional, Nakagawa, Tadahiko, additional, Tanaka, Hironori, additional, Tanaka, Takahiro, additional, Tomonari, Tetsu, additional, Okamoto, Koichi, additional, Sogabe, Masahiro, additional, Miyamoto, Hiroshi, additional, Okahisa, Toshiya, additional, Muguruma, Naoki, additional, Kajimoto, Mayumi, additional, Sagawa, Ikuko, additional, and Takayama, Tetsuji, additional

Published
2017
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21. Isotope mapping on mountainous regions: current state and way forward

Author

YAMANAKA, Tsutomu, primary, SUZUKI, Keisuke, additional, WAKIYAMA, Yoshifumi, additional, KISHI, Kazuhiro, additional, MAKINO, Yuki, additional, MARUYAMA, Kosuke, additional, KANO, Masaya, additional, MA, Wenchao, additional, MASAKI, Daisuke, additional, SUGIYAMA, Masanori, additional, YAMAKAWA, Yosuke, additional, and YOSHITAKE, Shimpei, additional

Published
2016
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22. Unusual endoscopic findings of gastric neuroendocrine tumor

Author

Kishi, Kazuhiro, Fujisawa, Akihiko, Horikita, Minoru, Nakai, Yoshihiro, Ooshimo, Kazushi, Kishi, Fumiko, Kimura, Masako, Lin, Chun-che, Takayama, Tetsuji, Kishi, Kazuhiro, Fujisawa, Akihiko, Horikita, Minoru, Nakai, Yoshihiro, Ooshimo, Kazushi, Kishi, Fumiko, Kimura, Masako, Lin, Chun-che, and Takayama, Tetsuji

Abstract

Gastric neuroendocrine tumor (NET) is sometimes found as a submucosal tumor on upper gastrointestinal endoscopy. Gastric NET with malignant profile and neuroendocrine carcinoma (NEC) show various forms which are difficult to distinguish from gastric cancer and other disease. We report a case of a cauliflower-shaped NET of the stomach. A 61-year-old man was referred to our hospital with a complaint of abdominal fullness. Upper gastrointestinal endoscopic examination revealed an unusual, whitish cauliflower-shaped tumor that belongs to Borrmann type I on the lesser curvature of the gastric antrum. Histological examination of the biopsy specimen revealed NET G2, because the tumor cells were CD56- and synaptophysin-positive by immunohistochemical analysis. A distal gastrectomy with D2 lymphadenectomy was performed. A recurrence in the liver was revealed by follow up computed tomography after 11 months from operation. Combined chemotherapy with irinotecan (CPT-11) plus cisplatin (CDDP) was treated. The patient achieved a partial response, but he died after 31 months from gastrectomy. There is no independent, large-scaled prospective study and no standard treatment for gastric NETs with distant metastases. Our case is reported with a literature review of the treatment of metastatic gastric NET G2.

Published
2015

23. Erratum. Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice. Diabetes 2003;52:2657—2665

Author

Minami, Asako, primary, Iseki, Masanori, additional, Kishi, Kazuhiro, additional, Wang, Miao, additional, Ogura, Makoto, additional, Furukawa, Noboru, additional, Hayashi, Sanae, additional, Yamada, Mizuki, additional, Obata, Toshiyuki, additional, Takeshita, Yukari, additional, Nakaya, Yutaka, additional, Bando, Yoshimi, additional, Izumi, Keisuke, additional, Moodie, Shonna A., additional, Kajiura, Fumiko, additional, Matsumoto, Mitsuru, additional, Takatsu, Kiyoshi, additional, Takaki, Satoshi, additional, and Ebina, Yousuke, additional

Published
2015
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34. The Rab GTPase-Activating Protein AS160 as a Common Regulator of Insulin- and G.ALPHA.q-Mediated Intracellular GLUT4 Vesicle Distribution

Author

YUASA, Tomoyuki, primary, UCHIYAMA, Keiji, additional, OGURA, Yuko, additional, KIMURA, Masafumi, additional, TESHIGAWARA, Kiyoshi, additional, HOSAKA, Toshio, additional, TANAKA, Yoshinori, additional, OBATA, Toshiyuki, additional, SANO, Hiroyuki, additional, KISHI, Kazuhiro, additional, and EBINA, Yousuke, additional

Published
2009
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35. Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose transporter type 1 (GLUT1) translocation in Chinese hamster ovary (CHO) cells stably expressing fMLP or PAF receptor

Author

Hagi, Akifumi, Hayashi, Hideki, Kishi, Kazuhiro, Lihong, Wang, Ebina, Yousuke, Hagi, Akifumi, Hayashi, Hideki, Kishi, Kazuhiro, Lihong, Wang, and Ebina, Yousuke

Abstract

The chemoattractants, fMLP and PAF, stimulate glucose uptake in phagocytes to obtain an energy source for host defense. Glucose uptake in phagocytes is mainly regulated via glucose transporter type1 (GLUT1). To examine molecular mechanisms of facilitated glucose uptake in response to fMLP or PAF, we established CHO cells stably expressing fMLP or PAF receptor with c-myc epitope tagged GLUT1 which could immunologically detect GLUT1 on the cell surface. In the CHO cells, both fMLP and PAF directly triggered GLUT1 translocation from the intracellular pool to the cell surface, and stimulated glucose uptake. Therefore, in phagocytes, we propose that fMLP and PAF also trigger GLUT1 translocation to stimulate glucose uptake as an energy source for host defense.

Published
2000

38. KATP Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-negative Form of Human Insulin Receptor Have Glucose Intolerance but not Diabetes

Author

KANEZAKI, Yoshiko, primary, OBATA, Toshiyuki, additional, MATSUSHIMA, Rie, additional, MINAMI, Asako, additional, YUASA, Tomoyuki, additional, KISHI, Kazuhiro, additional, BANDO, Yoshimi, additional, UEHARA, Hisanori, additional, IZUMI, Keisuke, additional, MITANI, Tasuku, additional, MATSUMOTO, Mitsuru, additional, TAKESHITA, Yukari, additional, NAKAYA, Yutaka, additional, MATSUMOTO, Toshio, additional, and EBINA, Yousuke, additional

Published
2004
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47. Roles of insulin, guanosine 5′-[γ-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation

Author

TODAKA, Mikio, primary, HAYASHI, Hideki, additional, IMANAKA, Takanobu, additional, MITANI, Yasumasa, additional, KAMOHARA, Seika, additional, KISHI, Kazuhiro, additional, TAMAOKA, Keisuke, additional, KANAI, Fumihiko, additional, SHICHIRI, Motoaki, additional, MORII, Narito, additional, NARUMIYA, Shuh, additional, and EBINA, Yousuke, additional

Published
1996
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49. Platelet-Derived Growth Factor Stimulates GlucoseTransport in Skeletal Muscles of Transgenic Mice SpecificallyExpressing Platelet-Derived Growth Factor Receptor in the Muscle,but It Does Not Affect Blood Glucose Levels.

Author

Yuasa, Tomoyuki, Kakuhata, Rei, Kishi, Kazuhiro, Obata, Toshiyuki, Shinohara, Yasuo, Bando, Yoshimi, Izumi, Keisuke, Kajiura, Fumiko, Matsumoto, Mitsuru, and Ebina, Yousuke

Subjects
INSULIN, GLUCOSE, BLOOD plasma, MUSCLES, CELL membranes
Abstract

Insulin stimulates the disposal of blood glucose into skeletal muscle and adipose tissues by the translocation of GLUT4 from intracellular pools to the plasma membrane, and consequently the concentration of blood glucose levels decreases rapidly in vivo. Phosphatidylinositol (PI) 3-kinase and Akt play a pivotal role in the stimulation of glucose transport by insulin, but detailed mechanisms are unknown. We and others reported that not only insulin but also platelet-derived growth factor (PDGF) and epidermal growth factor facilitate glucose uptake through GLUT4 translocation by activation of PI 3-kinase and Akt in cultured cells. However, opposite results were also reported. We generated transgenic mice that specifically express the PDGF receptor in skeletal muscle. In these mice, PDGF stimulated glucose transport into skeletal muscle in vitro and in vivo. Thus, PDGF apparently shares with insulin some of the signaling molecules needed for the stimulation of glucose transport. The degree of glucose uptake in vivo reached ∼60% of that by insulin injection in skeletal muscle, but blood glucose levels were not decreased by PDGF in these mice. Therefore, PDGF-induced disposal of blood glucose into skeletal muscle is insufficient for rapid decrease of blood glucose levels. [ABSTRACT FROM AUTHOR]

Published
2004

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