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BackgroundDiscrimination is a recognized psychosocial stressor that has been linked to various negative health outcomes. This study explored the impact of discrimination on gut health, specifically focusing on microbiome changes, predicted metagenomic differences, transcriptomic profiles, and the potential for using a multi-omic approach to predict discrimination to identify discrimination status for an individual. Methods: We conducted a comprehensive investigation involving male and premenopausal female participants, using the Everyday Discrimination Scale to classify them into either high or low discrimination. Multiple questionnaires were administered to evaluate participants’ physiological, psychological, and perceived stressors. Two diet questionnaires were also administered. Stool samples were collected for microbiome analysis and RNA sequencing. Microbial composition changes were analyzed using the Shannon index and Chao1 richness estimator for alpha diversity and the Aitchison distance metric for beta diversity. Differential abundance was evaluated using MaAsLin2, followed by metatranscriptomics sequencing and annotation. A multi-omic approach utilizing random forest was used to assess the predictability of discrimination.ResultsThe study results showed that high discrimination was linked to higher gut microbiome species richness (Chao1, p = 0.02) and significant beta diversity differences (p = 0.04). Prevotella and Ruminococcaceae were both less abundant in the high discrimination group. High discrimination participants also reported higher levels of depression, anxiety, perceived stress, early life adversity, visceral sensitivity, and neuroticism than those in the low discrimination group. Gene expression analysis revealed distinctive patterns, with significant changes in genes associated with environmental sensing (two-component system) and metabolic pathways. In a plot comparing gene transcription to DNA content, certain genes showed higher expression levels in participants who experienced both high and low levels of discrimination. Our random forest classifier demonstrated the capability to accurately differentiate individuals with high and low discrimination in our training cohort (AUC = 0.91).ConclusionThese findings illuminate the substantial impact of discrimination on gut health, encompassing microbiome composition, gene expression, and functional pathways. These findings suggest that discrimination is associated with internal biological changes that can be associated with negative health outcomes, opening research to examine novel pathways that can be used to mitigate the negative health effects of discrimination.

Quantum based systems are a relatively new research area for that different modelling languages including process calculi are currently under development. Encodings are often used to compare process calculi. Quality criteria are used then to rule out trivial or meaningless encodings. In this new context of quantum based systems, it is necessary to analyse the applicability of these quality criteria and to potentially extend or adapt them. As a first step, we test the suitability of classical criteria for encodings between quantum based languages and discuss new criteria. Concretely, we present an encoding, from a language inspired by CQP into a language inspired by qCCS. We show that this encoding satisfies compositionality, name invariance (for channel and qubit names), operational correspondence, divergence reflection, success sensitiveness, and that it preserves the size of quantum registers. Then we show that there is no encoding from qCCS into CQP that is compositional, operationally corresponding, and success sensitive.

Multiparty session types are designed to abstractly capture the structure of communication protocols and verify behavioural properties. One important such property is progress, i.e., the absence of deadlock. Distributed algorithms often resemble multiparty communication protocols. But proving their properties, in particular termination that is closely related to progress, can be elaborate. Since distributed algorithms are often designed to cope with faults, a first step towards using session types to verify distributed algorithms is to integrate fault-tolerance. We extend multiparty session types to cope with system failures such as unreliable communication and process crashes. Moreover, we augment the semantics of processes by failure patterns that can be used to represent system requirements (as, e.g., failure detectors). To illustrate our approach we analyse a variant of the well-known rotating coordinator algorithm by Chandra and Toueg.

Encodings or the proof of their absence are the main way to compare process calculi. To analyse the quality of encodings and to rule out trivial or meaningless encodings, they are augmented with encodability criteria. There exists a bunch of different criteria and different variants of criteria in order to reason in different settings. This leads to incomparable results. Moreover, it is not always clear whether the criteria used to obtain a result in a particular setting do indeed fit to this setting. This paper provides a short survey on often used encodability criteria, general frameworks that try to provide a unified notion of the quality of an encoding, and methods to analyse and compare encodability criteria.

Modern society is dependent on distributed software systems and to verify them different modelling languages such as mobile ambients were developed. To analyse the quality of mobile ambients as a good foundational model for distributed computation, we analyse the level of synchronisation between distributed components that they can express. Therefore, we rely on earlier established synchronisation patterns. It turns out that mobile ambients are not fully distributed, because they can express enough synchronisation to express a synchronisation pattern called M. However, they can express strictly less synchronisation than the standard pi-calculus. For this reason, we can show that there is no good and distributability-preserving encoding from the standard pi-calculus into mobile ambients and also no such encoding from mobile ambients into the join-calculus, i.e., the expressive power of mobile ambients is in between these languages. Finally, we discuss how these results can be used to obtain a fully distributed variant of mobile ambients.

Event Structures (ESs) address the representation of direct relationships between individual events, usually capturing the notions of causality and conflict. Up to now, such relationships have been static, i.e., they cannot change during a system run. Thus, the common ESs only model a static view on systems. We make causality dynamic by allowing causal dependencies between some events to be changed by occurrences of other events. We first model and study the case in which events may entail the removal of causal dependencies, then we consider the addition of causal dependencies, and finally we combine both approaches in the so-called Dynamic Causality ESs. For all three newly defined types of ESs, we study their expressive power in comparison to the well-known Prime ESs, Dual ESs, Extended Bundle ESs, and ESs for Resolvable Conflicts. Interestingly, Dynamic Causality ESs subsume Extended Bundle ESs and Dual ESs but are incomparable with ESs for Resolvable Conflicts.

Encodings or the proof of their absence are the main way to compare process calculi. To analyse the quality of encodings and to rule out trivial or meaningless encodings, they are augmented with quality criteria. There exists a bunch of different criteria and different variants of criteria in order to reason in different settings. This leads to incomparable results. Moreover it is not always clear whether the criteria used to obtain a result in a particular setting do indeed fit to this setting. We show how to formally reason about and compare encodability criteria by mapping them on requirements on a relation between source and target terms that is induced by the encoding function. In particular we analyse the common criteria full abstraction, operational correspondence, divergence reflection, success sensitiveness, and respect of barbs; e.g. we analyse the exact nature of the simulation relation (coupled simulation versus bisimulation) that is induced by different variants of operational correspondence. This way we reduce the problem of analysing or comparing encodability criteria to the better understood problem of comparing relations on processes.

We study encodings from CSP into asynchronous CCS with name passing and matching, so in fact, the asynchronous pi-calculus. By doing so, we discuss two different ways to map the multi-way synchronisation mechanism of CSP into the two-way synchronisation mechanism of CCS. Both encodings satisfy the criteria of Gorla except for compositionality, as both use an additional top-level context. Following the work of Parrow and Sjödin, the first encoding uses a centralised coordinator and establishes a variant of weak bisimilarity between source terms and their translations. The second encoding is decentralised, and thus more efficient, but ensures only a form of coupled similarity between source terms and their translations.

We study whether, in the pi-calculus, the match prefix—a conditional operator testing two names for (syntactic) equality—is expressible via the other operators. Previously, Carbone and Maffeis proved that matching is not expressible this way under rather strong requirements (preservation and reflection of observables). Later on, Gorla developed a by now widely-tested set of criteria for encodings that allows much more freedom (e.g. instead of direct translations of observables it allows comparison of calculi with respect to reachability of successful states). In this paper, we offer a considerably stronger separation result on the non-expressibility of matching using only Gorla's relaxed requirements.

Event Structures (ESs) are mainly concerned with the representation of causal relationships between events, usually accompanied by other event relations capturing conflicts and disabling. Among the most prominent variants of ESs are Prime ESs, Bundle ESs, Stable ESs, and Dual ESs, which differ in their causality models and event relations. Yet, some application domains require further kinds of relations between events. Here, we add the possibility to express priority relationships among events. We exemplify our approach on Prime, Bundle, Extended Bundle, and Dual ESs. Technically, we enhance these variants in the same way. For each variant, we then study the interference between priority and the other event relations. From this, we extract the redundant priority pairs—notably differing for the types of ESs—that enable us to provide a comparison between the extensions. We also exhibit that priority considerably complicates the definition of partial orders in ESs.

Given a synchronous system, we study the question whether the behaviour of that system can be exhibited by a (non-trivially) distributed and hence asynchronous implementation. In this paper we show, by counterexample, that synchronous systems cannot in general be implemented in an asynchronous fashion without either introducing an infinite implementation or changing the causal structure of the system behaviour.

We study the relation between process calculi that differ in their either synchronous or asynchronous interaction mechanism. Concretely, we are interested in the conditions under which synchronous interaction can be implemented using just asynchronous interactions in the pi-calculus. We assume a number of minimal conditions referring to the work of Gorla: a "good" encoding must be compositional and preserve and reflect computations, deadlocks, divergence, and success. Under these conditions, we show that it is not possible to encode synchronous interactions without introducing additional causal dependencies in the translation.

A well-known result by Palamidessi tells us that πmix (the π-calculus with mixed choice) is more expressive than πsep (its subset with only separate choice). The proof of this result argues with their different expressive power concerning leader election in symmetric networks. Later on, Gorla offered an arguably simpler proof that, instead of leader election in symmetric networks, employed the reducibility of incestual processes (mixed choices that include both enabled senders and receivers for the same channel) when running two copies in parallel. In both proofs, the role of breaking (initial) symmetries is more or less apparent. In this paper, we shed more light on this role by re-proving the above result - based on a proper formalization of what it means to break symmetries without referring to another layer of the distinguishing problem domain of leader election. Both Palamidessi and Gorla rephrased their results by stating that there is no uniform and reasonable encoding from πmix into πsep. We indicate how the respective proofs can be adapted and exhibit the consequences of varying notions of uniformity and reasonableness. In each case, the ability to break initial symmetries turns out to be essential.

Populations of swarming coupled oscillators with inhomogeneous natural frequencies and chirality are relevant for active matter systems and micro-robotics. The authors model and analyze a variety of their self-organized behaviors that mimic natural and artificial micro-scale collective systems.

Reconfigurability at the micro-scale is rare. Here, authors present a versatile magnetic microrobot collective that reconfigures on-demand among miscellaneous behaviors that allow for exploration, navigation, and interaction with diverse environments.