16 results on '"Kirsi Holli-Helenius"'
Search Results
2. 3D texture analysis reveals imperceptible MRI textural alterations in the thalamus and putamen in progressive myoclonic epilepsy type 1, EPM1.
- Author
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Sanna Suoranta, Kirsi Holli-Helenius, Päivi Koskenkorva, Eini Niskanen, Mervi Könönen, Marja Äikiä, Hannu Eskola, Reetta Kälviäinen, and Ritva Vanninen
- Subjects
Medicine ,Science - Abstract
Progressive myoclonic epilepsy type 1 (EPM1) is an autosomal recessively inherited neurodegenerative disorder characterized by young onset age, myoclonus and tonic-clonic epileptic seizures. At the time of diagnosis, the visual assessment of the brain MRI is usually normal, with no major changes found later. Therefore, we utilized texture analysis (TA) to characterize and classify the underlying properties of the affected brain tissue by means of 3D texture features. Sixteen genetically verified patients with EPM1 and 16 healthy controls were included in the study. TA was performed upon 3D volumes of interest that were placed bilaterally in the thalamus, amygdala, hippocampus, caudate nucleus and putamen. Compared to the healthy controls, EPM1 patients had significant textural differences especially in the thalamus and right putamen. The most significantly differing texture features included parameters that measure the complexity and heterogeneity of the tissue, such as the co-occurrence matrix-based entropy and angular second moment, and also the run-length matrix-based parameters of gray-level non-uniformity, short run emphasis and long run emphasis. This study demonstrates the usability of 3D TA for extracting additional information from MR images. Textural alterations which suggest complex, coarse and heterogeneous appearance were found bilaterally in the thalamus, supporting the previous literature on thalamic pathology in EPM1. The observed putamenal involvement is a novel finding. Our results encourage further studies on the clinical applications, feasibility, reproducibility and reliability of 3D TA.
- Published
- 2013
- Full Text
- View/download PDF
3. A Comparison of Regions of Interest in Parenchymal Analysis for Breast Cancer Risk Assessment.
- Author
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Gerson Africano, Otso Arponen, Antti Sassi, Mirva Karivaara-Mäkelä, Kirsi Holli-Helenius, Irina Rinta-Kiikka, Anna-Leena Lääperi, and Said Pertuz
- Published
- 2020
- Full Text
- View/download PDF
4. Morphological Area Gradient: System-independent Dense Tissue Segmentation in Mammography Images.
- Author
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German F. Torres, Antti Sassi, Otso Arponen, Kirsi Holli-Helenius, Anna-Leena Lääperi, Irina Rinta-Kiikka, Joni-Kristian Kämäräinen, and Said Pertuz
- Published
- 2019
- Full Text
- View/download PDF
5. Do Mammographic Systems Affect the Performance of Computerized Parenchymal Analysis?
- Author
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Said Pertuz, Antti Sassi, Otso Arponen, Kirsi Holli-Helenius, Anna-Leena Lääperi, and Irina Rinta-Kiikka
- Published
- 2019
- Full Text
- View/download PDF
6. Selecting the Mammographic-View for the Parenchymal Analysis-Based Breast Cancer Risk Assessment.
- Author
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Oscar Araque, María P. Mejía-Sandoval, Antti Sassi, Kirsi Holli-Helenius, Anna-Leena Lääperi, Irina Rinta-Kiikka, Otso Arponen, and Said Pertuz
- Published
- 2019
- Full Text
- View/download PDF
7. Perioperative acinar cell count method works well in the prediction of postoperative pancreatic fistula and other postoperative complications after pancreaticoduodenectomy
- Author
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Irina Rinta-Kiikka, Juhani Sand, Kirsi Holli-Helenius, Matias Laaninen, Ville Teränen, and Johanna Laukkarinen
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Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Fistula ,medicine.medical_treatment ,Acinar Cells ,Pancreaticoduodenectomy ,Pancreatic Fistula ,Young Adult ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Risk Factors ,medicine ,Acinar cell ,Humans ,Aged ,Aged, 80 and over ,Pancreatic duct ,Framingham Risk Score ,Hepatology ,business.industry ,Gastroenterology ,Perioperative ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Pancreatic fistula ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Pancreas ,business - Abstract
Background Earlier we have shown that high frequency of acinar cells in the pancreatic transsection line predicts postoperative pancreatic fistula after pancreaticoduodenectomy (PD). Acinar cell count method (ACM) is fast to perform during operation. In this study our aim was to validate the accuracy of ACM to compare it with other published risk prediction methods. Methods 87 patients who underwent PD without any trial including perioperative medications were collected from a single hospital. Data on demographics, surgical details, postoperative complications clinically relevant pancreatic fistulae (CR-POPF) and clinically relevant Clavien-Dindo complications (CR-CDC) were registered. Thirteen previously published risk prediction methods were included in the comparison, such as pancreatic duct diameter, palpable texture of pancreas, Braga score (BC), Fistula Risk Score, Modified Fistula Risk Score, Alternative Fistula Risk Score and multiple radiological parameters. ROC-curves were calculated to compare sensitivity and specificity for identifying high risk patients for CR-POPF and CR-CDC. Results The three most accurate risk prediction methods for CR-POPF were ACM (sensitivity 88.9%, specificity 52.6%; p = 0.043), BC (87.5%, 56.6%; p = 0.039) and visceral fat area to subcutaneous fat area ratio (75.5%, 80.0%; p = 0.032). In predicting CR-CDC the three most accurate methods were ACM (73.9%, 56.2%; p = 0.033), BC (68.4%, 59.5%; p = 0.036) and TPAI (78.3%, 41.7%; p = 0.012). Conclusion ACM was shown to be as good as the more complicated risk scoring methods in the prediction of CR-POPF. It was good also in predicting all clinically relevant complications. ACM is easy to use during operation and can be recommended as a routine risk prediction method.
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- 2021
8. Association between breast cancer’s prognostic factors and 3D textural features of non-contrast-enhanced T(1) weighted breast MRI
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Hidemi Okuma, Kirsi Holli-Helenius, Anna Sutela, Mazen Sudah, Anni Lepola, Heikki Junkkari, Otso Arponen, Mervi Könönen, Ritva Vanninen, and Päivi Auvinen
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Oncology ,Adult ,medicine.medical_specialty ,Tumour heterogeneity ,Entropy ,Breast Neoplasms ,Kaplan-Meier Estimate ,computer.software_genre ,Disease-Free Survival ,Statistics, Nonparametric ,030218 nuclear medicine & medical imaging ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Imaging, Three-Dimensional ,Voxel ,Internal medicine ,Medicine ,Breast MRI ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,Full Paper ,business.industry ,Proportional hazards model ,Contrast (statistics) ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Magnetic Resonance Imaging ,Tumor Burden ,030220 oncology & carcinogenesis ,Nottingham Prognostic Index ,Female ,Neoplasm Grading ,business ,computer - Abstract
Objectives: The aim of this exploratory study was to evaluate whether three-dimensional texture analysis (3D-TA) features of non-contrast-enhanced T1 weighted MRI associate with traditional prognostic factors and disease-free survival (DFS) of breast cancer. Methods: 3D-T1 weighted images from 78 patients with 81 malignant histopathologically verified breast lesions were retrospectively analysed using standard-size volumes of interest. Grey-level co-occurrence matrix (GLCM)-based features were selected for statistical analysis. In statistics the Mann–Whitney U and the Kruskal–Wallis tests, the Cox proportional hazards model and the Kaplan–Meier method were used. Results: Tumours with higher histological grade were significantly associated with higher contrast (1 voxel: p = 0.033, 2 voxels: p = 0.036). All the entropy parameters showed significant correlation with tumour grade (p = 0.015–0.050) but there were no statistically significant associations between other TA parameters and tumour grade. The Nottingham Prognostic Index (NPI) was correlated with contrast and sum entropy parameters. A higher sum variance TA parameter was a significant predictor of shorter DFS. Conclusion: Texture parameters, assessed by 3D-TA from non-enhanced T1 weighted images, indicate tumour heterogeneity but have limited independent prognostic value. However, they are associated with tumour grade, NPI, and DFS. These parameters could be used as an adjunct to contrast-enhanced TA parameters. Advances in knowledge: 3D-TA of non-contrast enhanced T1 weighted breast MRI associates with tumour grade, NPI, and DFS. The use of non-contrast 3D-TA parameters in adjunct with contrast-enhanced 3D-TA parameters warrants further research.
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- 2021
9. A Comparison of Regions of Interest in Parenchymal Analysis for Breast Cancer Risk Assessment
- Author
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Mirva Karivaara-Makela, Said Pertuz, Otso Arponen, Gerson Africano, Antti Sassi, Kirsi Holli-Helenius, Irina Rinta-Kiikka, and Anna-Leena Laaperi
- Subjects
medicine.medical_specialty ,Imaging biomarker ,business.industry ,Feature extraction ,Area under the curve ,Breast Neoplasms ,medicine.disease ,Risk Assessment ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Cancer risk assessment ,Region of interest ,030220 oncology & carcinogenesis ,Area Under Curve ,medicine ,Humans ,Female ,Whole breast ,Selection method ,Radiology ,business ,Mammography ,Retrospective Studies - Abstract
Computerized parenchymal analysis has shown potential to be utilized as an imaging biomarker to estimate the risk of breast cancer. Parenchymal analysis of digital mammograms is based on the extraction of computerized measures to build machine learning-based models for the prediction of breast cancer risk. However, the choice of the region of interest (ROI) for feature extraction within the breast remains an open problem. In this work we perform a comparison between five different methods suggested in the literature for automated ROI selection, including the whole breast (WB), the maximum squared (MS), the retro-areolar region (RA), the lattice-based (LB), and the polar-based (PB) selection methods. For the experiments, we built a retrospective dataset of 896 screening mammograms from 224 women (112 cases and 112 healthy controls). The performance of each ROI selection method was measured in terms of the area under the curve (AUC) values. The AUC values varied between 0.55 and 0.79 depending on the method and experimental settings. The best performance on an independent test set was achieved by the MS method (AUC of 0.59, 95% CI: 0.55-0.64). This method is fully-automated and does not require adjusting hyper-parameters. Based on our results, we prompt the use of the MS method for ROI selection in the computerized parenchymal analysis for breast cancer risk assessment.
- Published
- 2020
10. Clinical evaluation of a fully-automated parenchymal analysis software for breast cancer risk assessment: A pilot study in a Finnish sample
- Author
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Anna-Leena Laaperi, Irina Rinta-Kiikka, Joni Kamarainen, Otso Arponen, Antti Sassi, Kirsi Holli-Helenius, and Said Pertuz
- Subjects
medicine.medical_specialty ,Imaging biomarker ,Breast Neoplasms ,Pilot Projects ,Asymptomatic ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Cancer risk assessment ,Risk Factors ,Image Interpretation, Computer-Assisted ,Medicine ,Analysis software ,Humans ,Radiology, Nuclear Medicine and imaging ,Breast ,Finland ,Aged ,Retrospective Studies ,business.industry ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,030220 oncology & carcinogenesis ,Area Under Curve ,Case-Control Studies ,Female ,Radiology ,medicine.symptom ,business ,Risk assessment ,Algorithms ,Mammography - Abstract
Purpose To assess the association between breast cancer risk and mammographic parenchymal measures obtained using a fully-automated, publicly available software, OpenBreast. Methods This retrospective case-control study involved screening mammograms of asymptomatic women diagnosed with breast cancer between 2016 and 2017. The 114 cases were matched with corresponding healthy controls by birth and screening years and the mammographic system used. Parenchymal analysis was performed using OpenBreast, a software implementing a computerized parenchymal analysis algorithm. Breast percent density was measured with an interactive thresholding method. The parenchymal measures were Box-Cox transformed and adjusted for age and percent density. Changes in the odds ratio per standard deviation (OPERA) with 95% confidence intervals (CIs) and the area under the ROC curve (AUC) for parenchymal measures and percent densities were used to evaluate the discrimination between cases and controls. Differences in AUCs were assessed using DeLong’s test. Results The adjusted OPERA value of parenchymal measures was 2.49 (95% CI: 1.79–3.47). Parenchymal measures using OpenBreast were more accurate (AUC = 0.779) than percent density (AUC = 0.609) in discriminating between cases and controls (p Conclusions Parenchymal measures obtained with the evaluated software were positively associated with breast cancer risk and were more accurate than percent density in the prediction of risk.
- Published
- 2019
11. Morphological Area Gradient: System-independent Dense Tissue Segmentation in Mammography Images
- Author
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Antti Sassi, German F. Torres, Otso Arponen, Joni Kamarainen, Anna-Leena Laaperi, Irina Rinta-Kiikka, Kirsi Holli-Helenius, and Said Pertuz
- Subjects
Dense connective tissue ,Similarity (geometry) ,Computer science ,Breast Neoplasms ,030218 nuclear medicine & medical imaging ,Automation ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Gradient system ,Image Processing, Computer-Assisted ,medicine ,Humans ,Mammography ,Segmentation ,Breast ,medicine.diagnostic_test ,business.industry ,Pattern recognition ,Image segmentation ,medicine.disease ,nervous system ,Risk factors for breast cancer ,030220 oncology & carcinogenesis ,Calibration ,Female ,Artificial intelligence ,business ,Algorithms - Abstract
Breast density has been identified as one of the strongest risk factors for breast cancer. However, the development of reliable and reproducible methods for the automatic dense tissue segmentation has been an important challenge. Due to the complexity of the acquisition process of mammography images, current approaches need to be calibrated for specific mammographic systems or require access to raw mammograms. In this work, we introduce the Morphological Area Gradient (MAG) as a generic measure for mammography images. MAG is generic in the sense that it does not need calibration or access to raw mammograms. At the core of MAG is the derivative of the area of segmented tissue with respect to the pixel intensity. We have found that the high-density regions can be automatically segmented by minimizing the MAG of a mammogram. To verify the performance of MAG, we collected 566 full-field digital mammograms using two different medical devices and a human expert manually annotated the high-density regions in each image. The proposed MAG method yields a median absolute error of 7.6% and a Dices similarity coefficient of 0.83, which are superior to other clinically validated state-of-the-art algorithms.
- Published
- 2019
12. Impact of prone, supine and oblique patient positioning on CBCT image quality, contrast-to-noise ratio and figure of merit value in the maxillofacial region
- Author
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Jorma Järnstedt, Maureen van Eijnatten, Jan Wolff, Kirsi Holli-Helenius, Juha Koivisto, Prasun Dastidar, MKA VUmc (ORM, ACTA), Maxillofacial Surgery (VUmc), Oral and Maxillofacial Surgery / Oral Pathology, and AMS - Trauma and Reconstruction
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Scanner ,medicine.medical_specialty ,Supine position ,Image quality ,Patient Positioning ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Contrast-to-noise ratio ,stomatognathic system ,Cadaver ,Prone Position ,Supine Position ,Humans ,Medicine ,Figure of merit ,Radiology, Nuclear Medicine and imaging ,General Dentistry ,business.industry ,Oblique case ,030206 dentistry ,General Medicine ,Cone-Beam Computed Tomography ,Otorhinolaryngology ,Maxilla ,Radiology ,business ,Head ,Research Article - Abstract
Objectives: To assess the impact of supine, prone and oblique patient imaging positions on the image quality, contrast-to-noise ratio (CNR) and figure of merit (FOM) value in the maxillofacial region using a CBCT scanner. Furthermore, the CBCT supine images were compared with supine multislice CT (MSCT) images.Methods: One fresh frozen cadaver head was scanned in prone, supine and oblique imaging positions using a mobile CBCT scanner. MSCT images of the head were acquired in a supine position. Two radiologists graded the CBCT and MSCT images at ten different anatomical sites according to their image quality using a six-point scale. The CNR and FOM values were calculated at two different anatomical sites on the CBCT and MSCT images.Results: The best image quality was achieved in the prone imaging position for sinus, mandible and maxilla, followed by the supine and oblique imaging positions. 12-mA prone images presented high delineation scores for all anatomical landmarks, except for the ear region (carotid canal), which presented adequate to poor delineation scores for all studied head positions and exposure parameters. The MSCT scanner offered similar image qualities to the 7.5-mA supine images acquired using the mobile CBCT scanner. The prone imaging position offered the best CNR and FOM values on the mobile CBCT scanner.Conclusions: Head positioning has an impact on CBCT image quality. The best CBCT image quality can be achieved using the prone and supine imaging positions. The oblique imaging position offers inadequate image quality except in the sinus region.
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- 2017
13. Micro-parenchymal patterns for breast cancer risk assessment
- Author
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Anna-Leena Laaperi, Irina Rinta-Kiikka, Antti Sassi, Joni-Kristian Kamarainen, Mirva Karivaara-Makela, Kirsi Holli-Helenius, Said Pertuz, and Otso Arponen
- Subjects
Oncology ,medicine.medical_specialty ,Cancer risk assessment ,business.industry ,Internal medicine ,Parenchyma ,medicine ,business ,General Nursing - Published
- 2019
14. MR image texture in Parkinson's disease: a longitudinal study
- Author
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Hannu Eskola, Pertti Ryymin, Kirsi Holli-Helenius, Lara C V Harrison, Tiia Saunamäki, Irina Elovaara, Minna Sikiö, Hanna Ruottinen, and Prasun Dastidar
- Subjects
Male ,medicine.medical_specialty ,Longitudinal study ,Parkinson's disease ,Texture (music) ,Sensitivity and Specificity ,Image texture ,Healthy volunteers ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Longitudinal Studies ,Aged ,Aged, 80 and over ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Brain ,Reproducibility of Results ,Magnetic resonance imaging ,Parkinson Disease ,General Medicine ,Middle Aged ,medicine.disease ,Image Enhancement ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Human eye ,Female ,Radiology ,Mr images ,business ,Algorithms - Abstract
Background Few of the structural changes caused by Parkinson’s disease (PD) are visible in magnetic resonance imaging (MRI) with visual inspection but there is a need for a method capable of observing the changes beyond the human eye. Texture analysis offers a technique that enables the quantification of the image gray-level patterns. Purpose To investigate the value of quantitative image texture analysis method in diagnosis and follow-up of PD patients. Material and Methods Twenty-six PD patients underwent MRI at baseline and after 2 years of follow-up. Four co-occurrence matrix-based texture parameters, describing the image homogeneity and complexity, were calculated within clinically interesting areas of the brain. In addition, correlations with clinical characteristics (Unified Parkinson’s Disease Ranking Scales I–III and Mini-Mental State Examination score) along with a comparison to healthy controls were evaluated. Results Patients at baseline and healthy volunteers differed in their brain MR image textures mostly in the areas of substantia nigra pars compacta, dentate nucleus, and basilar pons. During the 2-year follow-up of the patients, textural differences appeared mainly in thalamus and corona radiata. Texture parameters in all the above mentioned areas were also found to be significantly related to clinical scores describing the severity of PD. Conclusion Texture analysis offers a quantitative method for detecting structural changes in brain MR images. However, the protocol and repeatability of the method must be enhanced before possible clinical use.
- Published
- 2014
15. 3D Texture Analysis Reveals Imperceptible MRI Textural Alterations in the Thalamus and Putamen in Progressive Myoclonic Epilepsy Type 1, EPM1
- Author
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Kirsi Holli-Helenius, Eini Niskanen, Marja Äikiä, Hannu Eskola, Reetta Kälviäinen, Ritva Vanninen, Sanna Suoranta, Mervi Könönen, and Päivi Koskenkorva
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Anatomy and Physiology ,Medical Physics ,Adolescent ,Thalamus ,Caudate nucleus ,lcsh:Medicine ,Progressive myoclonus epilepsy ,Amygdala ,Neurological System ,Diagnostic Radiology ,Epilepsy ,Young Adult ,medicine ,Humans ,lcsh:Science ,Child ,Motor Systems ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,Putamen ,Physics ,lcsh:R ,Magnetic resonance imaging ,Neurodegenerative Diseases ,medicine.disease ,Myoclonic Epilepsies, Progressive ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Neurology ,Medicine ,lcsh:Q ,Ganglia ,Female ,medicine.symptom ,business ,Radiology ,Myoclonus ,Research Article - Abstract
Progressive myoclonic epilepsy type 1 (EPM1) is an autosomal recessively inherited neurodegenerative disorder characterized by young onset age, myoclonus and tonic-clonic epileptic seizures. At the time of diagnosis, the visual assessment of the brain MRI is usually normal, with no major changes found later. Therefore, we utilized texture analysis (TA) to characterize and classify the underlying properties of the affected brain tissue by means of 3D texture features. Sixteen genetically verified patients with EPM1 and 16 healthy controls were included in the study. TA was performed upon 3D volumes of interest that were placed bilaterally in the thalamus, amygdala, hippocampus, caudate nucleus and putamen. Compared to the healthy controls, EPM1 patients had significant textural differences especially in the thalamus and right putamen. The most significantly differing texture features included parameters that measure the complexity and heterogeneity of the tissue, such as the co-occurrence matrix-based entropy and angular second moment, and also the run-length matrix-based parameters of gray-level non-uniformity, short run emphasis and long run emphasis. This study demonstrates the usability of 3D TA for extracting additional information from MR images. Textural alterations which suggest complex, coarse and heterogeneous appearance were found bilaterally in the thalamus, supporting the previous literature on thalamic pathology in EPM1. The observed putamenal involvement is a novel finding. Our results encourage further studies on the clinical applications, feasibility, reproducibility and reliability of 3D TA.
- Published
- 2013
16. Micro-parenchymal patterns for breast cancer risk assessment.
- Author
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Said Pertuz, Antti Sassi, Mirva Karivaara-Mäkelä, Kirsi Holli-Helenius, Anna-Leena Lääperi, Irina Rinta-Kiikka, Otso Arponen, and Joni-Kristian Kämäräinen
- Published
- 2019
- Full Text
- View/download PDF
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