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1. BMI and breast cancer risk around age at menopause

Author

Von Holle, Ann, Adami, Hans-Olov, Baglietto, Laura, Berrington de Gonzalez, Amy, Bertrand, Kimberly A., Blot, William, Chen, Yu, DeHart, Jessica Clague, Dossus, Laure, Eliassen, A. Heather, Fournier, Agnes, Garcia-Closas, Montse, Giles, Graham, Guevara, Marcela, Hankinson, Susan E., Heath, Alicia, Jones, Michael E., Joshu, Corinne E., Kaaks, Rudolf, Kirsh, Victoria A., Kitahara, Cari M., Koh, Woon-Puay, Linet, Martha S., Park, Hannah Lui, Masala, Giovanna, Mellemkjaer, Lene, Milne, Roger L., O'Brien, Katie M., Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Shrubsole, Martha J., Sund, Malin, Tamimi, Rulla, Tin Tin, Sandar, Visvanathan, Kala, Vermeulen, Roel CH, Weiderpass, Elisabete, Willett, Walter C., Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Nichols, Hazel B., Sandler, Dale P., Swerdlow, Anthony J., Schoemaker, Minouk J., and Weinberg, Clarice R.

Published
2024
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3. Endogenous sex steroid hormones and risk of liver cancer among US men: Results from the Liver Cancer Pooling Project

Author

Wu, Zeni, Petrick, Jessica L., Florio, Andrea A., Guillemette, Chantal, Beane Freeman, Laura E., Buring, Julie E., Bradwin, Gary, Caron, Patrick, Chen, Yu, Eliassen, A. Heather, Engel, Lawrence S., Freedman, Neal D., Gaziano, J. Michael, Giovannuci, Edward L., Hofmann, Jonathan N., Huang, Wen-Yi, Kirsh, Victoria A., Kitahara, Cari M., Koshiol, Jill, Lee, I-Min, Liao, Linda M., Newton, Christina C., Palmer, Julie R., Purdue, Mark P., Rohan, Thomas E., Rosenberg, Lynn, Sesso, Howard D., Sinha, Rashmi, Stampfer, Meir J., Um, Caroline Y., Van Den Eeden, Stephen K., Visvanathan, Kala, Wactawski-Wende, Jean, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, Graubard, Barry I., Campbell, Peter T., and McGlynn, Katherine A.

Published
2023
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4. Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S, Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E, de González, Amy Berrington, Buring, Julie E, Fraser, Gary E, Freedman, Neal D, Gapstur, Susan M, Gierach, Gretchen, Giles, Graham G, Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F, Lan, Qing, Larsson, Susanna C, Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M, Milne, Roger L, Monroe, Kristine R, Neuhouser, Marian L, O'Brien, Katie M, Petrick, Jessica L, Purdue, Mark P, Rohan, Thomas E, Sandin, Sven, Sandler, Dale P, Sawada, Norie, Shadyab, Aladdin H, Simon, Tracey G, Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-I, Zheng, Wei, McGlynn, Katherine A, Campbell, Peter T, and Koshiol, Jill

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Prevention, Clinical Research, Contraception/Reproduction, Digestive Diseases, Cancer, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Adult, Aged, Biliary Tract Neoplasms, Female, Follow-Up Studies, Global Health, Humans, Incidence, Middle Aged, Prospective Studies, Registries, Reproduction, Risk Assessment, Risk Factors, Sex Factors, Survival Rate, Time Factors, Young Adult, Reproductive factors, Parity, Biliary tract cancer, Gallbladder cancer, Public Health and Health Services, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsGallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear.MethodsWe pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study.ResultsDuring 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR ≥5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only.ConclusionWe observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography.Lay summaryOur findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepatic bile duct cancer and extrahepatic bile duct cancer. We did not see this same association in women from Western countries. Age at menopause was not associated with the risk of any biliary tract cancers.

Published
2020

5. Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project

Author

Florio, Andrea A, Campbell, Peter T, Zhang, Xuehong, Zeleniuch‐Jacquotte, Anne, Wactawski‐Wende, Jean, Smith‐Warner, Stephanie A, Sinha, Rashmi, Simon, Tracey G, Sesso, Howard D, Schairer, Catherine, Rosenberg, Lynn, Rohan, Thomas E, Robien, Kim, Renehan, Andrew G, Purdue, Mark P, Poynter, Jenny N, Palmer, Julie R, Newton, Christina C, Lu, Yunxia, Linet, Martha S, Liao, Linda M, Lee, I‐Min, Koshiol, Jill, Kitahara, Cari M, Kirsh, Victoria A, Hofmann, Jonathan N, Graubard, Barry I, Giovannucci, Edward, Gaziano, John M, Gapstur, Susan M, Freedman, Neal D, Demuth, Jane, Chong, Dawn Q, Chan, Andrew T, Buring, Julie E, Bradshaw, Patrick T, Freeman, Laura E Beane, McGlynn, Katherine A, and Petrick, Jessica L

Subjects
Obesity, Rare Diseases, Cancer, Liver Disease, Digestive Diseases, Clinical Research, Liver Cancer, Prevention, Adiposity, Adult, Aged, Bile Duct Neoplasms, Body Mass Index, Carcinoma, Hepatocellular, Cholangiocarcinoma, Female, Humans, Liver Neoplasms, Male, Middle Aged, Prospective Studies, Waist Circumference, Waist-Hip Ratio, hepatocellular carcinoma, intrahepatic cholangiocarcinoma, abdominal obesity, gluteofemoral obesity, epidemiology, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Obesity is known to be associated with primary liver cancer (PLC), but the separate effects of excess abdominal and gluteofemoral size are unclear. Thus, we examined the association between waist and hip circumference with risk of PLC overall and by histologic type-hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The Liver Cancer Pooling Project is a consortium of prospective cohort studies that include data from 1,167,244 individuals (PLC n = 2,208, HCC n = 1,154, ICC n = 335). Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression. Waist circumference, per 5 cm increase, was associated with an 11% increased PLC risk (HR = 1.11, 95%CI: 1.09-1.14), including when adjusted for hip circumference (HR = 1.12, 95%CI: 1.08-1.17) and also when restricted to individuals in a normal body mass index (BMI) range (18.5 to

Published
2020

6. Exogenous hormone use, reproductive factors and risk of intrahepatic cholangiocarcinoma among women: results from cohort studies in the Liver Cancer Pooling Project and the UK Biobank

Author

Petrick, Jessica L, McMenamin, Úna C, Zhang, Xuehong, Zeleniuch-Jacquotte, Anne, Wactawski-Wende, Jean, Simon, Tracey G, Sinha, Rashmi, Sesso, Howard D, Schairer, Catherine, Rosenberg, Lynn, Rohan, Thomas E, Robien, Kim, Purdue, Mark P, Poynter, Jenny N, Palmer, Julie R, Lu, Yunxia, Linet, Martha S, Liao, Linda M, Lee, I-Min, Koshiol, Jill, Kitahara, Cari M, Kirsh, Victoria A, Hofmann, Jonathan N, Graubard, Barry I, Giovannucci, Edward, Gaziano, J Michael, Gapstur, Susan M, Freedman, Neal D, Florio, Andrea A, Chong, Dawn Q, Chen, Yu, Chan, Andrew T, Buring, Julie E, Freeman, Laura E Beane, Bea, Jennifer W, Cardwell, Christopher R, Campbell, Peter T, and McGlynn, Katherine A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Liver Disease, Cancer, Digestive Diseases, Contraception/Reproduction, Clinical Research, Digestive Diseases - (Gallbladder), Liver Cancer, Prevention, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Reproductive health and childbirth, Good Health and Well Being, Aged, Bile Ducts, Bile Ducts, Intrahepatic, Biological Specimen Banks, Cholangiocarcinoma, Cohort Studies, Contraceptives, Oral, Hormonal, Estrogen Receptor alpha, Estrogen Receptor beta, Female, Gene Expression Regulation, Neoplastic, Hormones, Humans, Hysterectomy, Liver Neoplasms, Menopause, Middle Aged, Proportional Hazards Models, Risk Factors, United Kingdom, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundIntrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. Cholangiocytes express both oestrogen receptor-α and -β, and oestrogens positively modulate cholangiocyte proliferation. Studies in women and men have reported higher circulating oestradiol is associated with increased ICC risk, further supporting a hormonal aetiology. However, no observational studies have examined the associations between exogenous hormone use and reproductive factors, as proxies of endogenous hormone levels, and risk of ICC.MethodsWe harmonised data from 1,107,498 women who enroled in 12 North American-based cohort studies (in the Liver Cancer Pooling Project, LCPP) and the UK Biobank between 1980-1998 and 2006-2010, respectively. Cox proportional hazards regression models were used to generate hazard ratios (HR) and 95% confidence internals (CI). Then, meta-analytic techniques were used to combine the estimates from the LCPP (n = 180 cases) and the UK Biobank (n = 57 cases).ResultsHysterectomy was associated with a doubling of ICC risk (HR = 1.98, 95% CI: 1.27-3.09), compared to women aged 50-54 at natural menopause. Long-term oral contraceptive use (9+ years) was associated with a 62% increased ICC risk (HR = 1.62, 95% CI: 1.03-2.55). There was no association between ICC risk and other exogenous hormone use or reproductive factors.ConclusionsThis study suggests that hysterectomy and long-term oral contraceptive use may be associated with an increased ICC risk.

Published
2020

8. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts

Author

Epi Kanker, JC onderzoeksprogramma Cancer, Cancer, Timmins, Iain R, Jones, Michael E, O'Brien, Katie M, Adami, Hans-Olov, Aune, Dagfinn, Baglietto, Laura, Bertrand, Kimberly A, Brantley, Kristen D, Chen, Yu, Clague DeHart, Jessica, Clendenen, Tess V, Dossus, Laure, Eliassen, A Heather, Fletcher, Olivia, Fournier, Agnès, Håkansson, Niclas, Hankinson, Susan E, Houlston, Richard S, Joshu, Corinne E, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Linet, Martha S, Park, Hannah Lui, Lynch, Brigid M, May, Anne M, Mellemkjær, Lene, Milne, Roger L, Palmer, Julie R, Ricceri, Fulvio, Rohan, Thomas E, Ruddy, Kathryn J, Sánchez, Maria-Jose, Shu, Xiao-Ou, Smith-Byrne, Karl, Steindorf, Karen, Sund, Malin, Vachon, Celine M, Vatten, Lars J, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C, Wolk, Alicja, Yuan, Jian-Min, Zheng, Wei, Nichols, Hazel B, Sandler, Dale P, Swerdlow, Anthony J, Schoemaker, Minouk J, Epi Kanker, JC onderzoeksprogramma Cancer, Cancer, Timmins, Iain R, Jones, Michael E, O'Brien, Katie M, Adami, Hans-Olov, Aune, Dagfinn, Baglietto, Laura, Bertrand, Kimberly A, Brantley, Kristen D, Chen, Yu, Clague DeHart, Jessica, Clendenen, Tess V, Dossus, Laure, Eliassen, A Heather, Fletcher, Olivia, Fournier, Agnès, Håkansson, Niclas, Hankinson, Susan E, Houlston, Richard S, Joshu, Corinne E, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Linet, Martha S, Park, Hannah Lui, Lynch, Brigid M, May, Anne M, Mellemkjær, Lene, Milne, Roger L, Palmer, Julie R, Ricceri, Fulvio, Rohan, Thomas E, Ruddy, Kathryn J, Sánchez, Maria-Jose, Shu, Xiao-Ou, Smith-Byrne, Karl, Steindorf, Karen, Sund, Malin, Vachon, Celine M, Vatten, Lars J, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C, Wolk, Alicja, Yuan, Jian-Min, Zheng, Wei, Nichols, Hazel B, Sandler, Dale P, Swerdlow, Anthony J, and Schoemaker, Minouk J

Published
2024

9. BMI and breast cancer risk around age at menopause

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Von Holle, Ann, Adami, Hans-Olov, Baglietto, Laura, Berrington, Amy, Bertrand, Kimberly A, Blot, William, Chen, Yu, DeHart, Jessica Clague, Dossus, Laure, Eliassen, A Heather, Fournier, Agnes, Garcia-Closas, Montse, Giles, Graham, Guevara, Marcela, Hankinson, Susan E, Heath, Alicia, Jones, Michael E, Joshu, Corinne E, Kaaks, Rudolf, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Linet, Martha S, Park, Hannah Lui, Masala, Giovanna, Mellemkjaer, Lene, Milne, Roger L, O'Brien, Katie M, Palmer, Julie R, Riboli, Elio, Rohan, Thomas E, Shrubsole, Martha J, Sund, Malin, Tamimi, Rulla, Tin Tin, Sandar, Visvanathan, Kala, Vermeulen, Roel Ch, Weiderpass, Elisabete, Willett, Walter C, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Nichols, Hazel B, Sandler, Dale P, Swerdlow, Anthony J, Schoemaker, Minouk J, Weinberg, Clarice R, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Von Holle, Ann, Adami, Hans-Olov, Baglietto, Laura, Berrington, Amy, Bertrand, Kimberly A, Blot, William, Chen, Yu, DeHart, Jessica Clague, Dossus, Laure, Eliassen, A Heather, Fournier, Agnes, Garcia-Closas, Montse, Giles, Graham, Guevara, Marcela, Hankinson, Susan E, Heath, Alicia, Jones, Michael E, Joshu, Corinne E, Kaaks, Rudolf, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Linet, Martha S, Park, Hannah Lui, Masala, Giovanna, Mellemkjaer, Lene, Milne, Roger L, O'Brien, Katie M, Palmer, Julie R, Riboli, Elio, Rohan, Thomas E, Shrubsole, Martha J, Sund, Malin, Tamimi, Rulla, Tin Tin, Sandar, Visvanathan, Kala, Vermeulen, Roel Ch, Weiderpass, Elisabete, Willett, Walter C, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Nichols, Hazel B, Sandler, Dale P, Swerdlow, Anthony J, Schoemaker, Minouk J, and Weinberg, Clarice R

Published
2024

10. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts

Author

Timmins, Iain R., primary, Jones, Michael E., additional, O'Brien, Katie M., additional, Adami, Hans-Olov, additional, Aune, Dagfinn, additional, Baglietto, Laura, additional, Bertrand, Kimberly A., additional, Brantley, Kristen D., additional, Chen, Yu, additional, Clague DeHart, Jessica, additional, Clendenen, Tess V., additional, Dossus, Laure, additional, Eliassen, A. Heather, additional, Fletcher, Olivia, additional, Fournier, Agnès, additional, Håkansson, Niclas, additional, Hankinson, Susan E., additional, Houlston, Richard S., additional, Joshu, Corinne E., additional, Kirsh, Victoria A., additional, Kitahara, Cari M., additional, Koh, Woon-Puay, additional, Linet, Martha S., additional, Park, Hannah Lui, additional, Lynch, Brigid M., additional, May, Anne M., additional, Mellemkjær, Lene, additional, Milne, Roger L., additional, Palmer, Julie R., additional, Ricceri, Fulvio, additional, Rohan, Thomas E., additional, Ruddy, Kathryn J., additional, Sánchez, Maria-Jose, additional, Shu, Xiao-Ou, additional, Smith-Byrne, Karl, additional, Steindorf, Karen, additional, Sund, Malin, additional, Vachon, Celine M., additional, Vatten, Lars J., additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Willett, Walter C., additional, Wolk, Alicja, additional, Yuan, Jian-Min, additional, Zheng, Wei, additional, Nichols, Hazel B., additional, Sandler, Dale P., additional, Swerdlow, Anthony J., additional, and Schoemaker, Minouk J., additional

Published
2023
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11. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts.

Author

Timmins, Iain R., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Aune, Dagfinn, Baglietto, Laura, Bertrand, Kimberly A., Brantley, Kristen D., Chen, Yu, Clague DeHart, Jessica, Clendenen, Tess V., Dossus, Laure, Eliassen, A. Heather, Fletcher, Olivia, Fournier, Agnès, Håkansson, Niclas, Hankinson, Susan E., Houlston, Richard S., Joshu, Corinne E., and Kirsh, Victoria A.

Published
2024
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14. The evolution of SARS-CoV-2 seroprevalence in Canada: a time-series study, 2020–2023

Author

Murphy, Tanya J., primary, Swail, Hanna, additional, Jain, Jaspreet, additional, Anderson, Maureen, additional, Awadalla, Philip, additional, Behl, Lesley, additional, Brown, Patrick E., additional, Charlton, Carmen L., additional, Colwill, Karen, additional, Drews, Steven J., additional, Gingras, Anne-Claude, additional, Hinshaw, Deena, additional, Jha, Prabhat, additional, Kanji, Jamil N., additional, Kirsh, Victoria A., additional, Lang, Amanda L.S., additional, Langlois, Marc-André, additional, Lee, Stephen, additional, Lewin, Antoine, additional, O’Brien, Sheila F., additional, Pambrun, Chantale, additional, Skead, Kimberly, additional, Stephens, David A., additional, Stein, Derek R., additional, Tipples, Graham, additional, Van Caeseele, Paul G., additional, Evans, Timothy G., additional, Oxlade, Olivia, additional, Mazer, Bruce D., additional, and Buckeridge, David L., additional

Published
2023
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16. Supplementary Table 1 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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17. Data from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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18. Supplementary Table 2 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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19. Data from The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium

Author

Nichols, Hazel B., primary, Schoemaker, Minouk J., primary, Wright, Lauren B., primary, McGowan, Craig, primary, Brook, Mark N., primary, McClain, Kathleen M., primary, Jones, Michael E., primary, Adami, Hans-Olov, primary, Agnoli, Claudia, primary, Baglietto, Laura, primary, Bernstein, Leslie, primary, Bertrand, Kimberly A., primary, Blot, William J., primary, Boutron-Ruault, Marie-Christine, primary, Butler, Lesley, primary, Chen, Yu, primary, Doody, Michele M., primary, Dossus, Laure, primary, Eliassen, A. Heather, primary, Giles, Graham G., primary, Gram, Inger T., primary, Hankinson, Susan E., primary, Hoffman-Bolton, Judy, primary, Kaaks, Rudolf, primary, Key, Timothy J., primary, Kirsh, Victoria A., primary, Kitahara, Cari M., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lund, Eiliv, primary, Ma, Huiyan, primary, Merritt, Melissa A., primary, Milne, Roger L., primary, Navarro, Carmen, primary, Overvad, Kim, primary, Ozasa, Kotaro, primary, Palmer, Julie R., primary, Peeters, Petra H., primary, Riboli, Elio, primary, Rohan, Thomas E., primary, Sadakane, Atsuko, primary, Sund, Malin, primary, Tamimi, Rulla M., primary, Trichopoulou, Antonia, primary, Vatten, Lars, primary, Visvanathan, Kala, primary, Weiderpass, Elisabete, primary, Willett, Walter C., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, Zheng, Wei, primary, Sandler, Dale P., primary, and Swerdlow, Anthony J., primary

Published
2023
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20. Table S1 from The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium

Author

Nichols, Hazel B., primary, Schoemaker, Minouk J., primary, Wright, Lauren B., primary, McGowan, Craig, primary, Brook, Mark N., primary, McClain, Kathleen M., primary, Jones, Michael E., primary, Adami, Hans-Olov, primary, Agnoli, Claudia, primary, Baglietto, Laura, primary, Bernstein, Leslie, primary, Bertrand, Kimberly A., primary, Blot, William J., primary, Boutron-Ruault, Marie-Christine, primary, Butler, Lesley, primary, Chen, Yu, primary, Doody, Michele M., primary, Dossus, Laure, primary, Eliassen, A. Heather, primary, Giles, Graham G., primary, Gram, Inger T., primary, Hankinson, Susan E., primary, Hoffman-Bolton, Judy, primary, Kaaks, Rudolf, primary, Key, Timothy J., primary, Kirsh, Victoria A., primary, Kitahara, Cari M., primary, Koh, Woon-Puay, primary, Larsson, Susanna C., primary, Lund, Eiliv, primary, Ma, Huiyan, primary, Merritt, Melissa A., primary, Milne, Roger L., primary, Navarro, Carmen, primary, Overvad, Kim, primary, Ozasa, Kotaro, primary, Palmer, Julie R., primary, Peeters, Petra H., primary, Riboli, Elio, primary, Rohan, Thomas E., primary, Sadakane, Atsuko, primary, Sund, Malin, primary, Tamimi, Rulla M., primary, Trichopoulou, Antonia, primary, Vatten, Lars, primary, Visvanathan, Kala, primary, Weiderpass, Elisabete, primary, Willett, Walter C., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, Zheng, Wei, primary, Sandler, Dale P., primary, and Swerdlow, Anthony J., primary

Published
2023
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23. Harnessing the power of data linkage to enrich the cancer research ecosystem in Canada.

Author

Urquhart, Robin, primary, Awadalla, Philip, additional, Bhatti, Parveen, additional, Dummer, Trevor, additional, Gravel, Simon, additional, Vena, Jennifer, additional, Alvi, Riaz, additional, Broet, Philippe, additional, Kendell, Cynthia, additional, Kirsh, Victoria, additional, Lettre, Guillaume, additional, Skead, Kimberly, additional, Shen-Tu, Grace, additional, Sweeney, Ellen, additional, and Turner, Donna, additional

Published
2022
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24. Cohort Profile: The Ontario Health Study (OHS)

Author

Kirsh, Victoria A, primary, Skead, Kimberly, additional, McDonald, Kelly, additional, Kreiger, Nancy, additional, Little, Julian, additional, Menard, Karen, additional, McLaughlin, John, additional, Mukherjee, Sutapa, additional, Palmer, Lyle J, additional, Goel, Vivek, additional, Purdue, Mark P, additional, and Awadalla, Philip, additional

Published
2022
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25. Cohort Profile : The Ovarian Cancer Cohort Consortium (OC3).

Author

Townsend, Mary K, Trabert, Britton, Fortner, Renée T, Arslan, Alan A, Buring, Julie E, Carter, Brian D, Giles, Graham G, Irvin, Sarah R, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Koh, Woon-Puay, Lacey, James V, Langseth, Hilde, Larsson, Susanna C, Lee, I-Min, Martínez, María Elena, Merritt, Melissa A, Milne, Roger L, O'Brien, Katie M, Orlich, Michael J, Palmer, Julie R, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Robien, Kim, Rohan, Thomas E, Rosenberg, Lynn, Sandin, Sven, Sandler, Dale P, Schouten, Leo J, Setiawan, V Wendy, Swerdlow, Anthony J, Ursin, Giske, van den Brandt, Piet A, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Wentzensen, Nicolas, Townsend, Mary K, Trabert, Britton, Fortner, Renée T, Arslan, Alan A, Buring, Julie E, Carter, Brian D, Giles, Graham G, Irvin, Sarah R, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Koh, Woon-Puay, Lacey, James V, Langseth, Hilde, Larsson, Susanna C, Lee, I-Min, Martínez, María Elena, Merritt, Melissa A, Milne, Roger L, O'Brien, Katie M, Orlich, Michael J, Palmer, Julie R, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Robien, Kim, Rohan, Thomas E, Rosenberg, Lynn, Sandin, Sven, Sandler, Dale P, Schouten, Leo J, Setiawan, V Wendy, Swerdlow, Anthony J, Ursin, Giske, van den Brandt, Piet A, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, and Wentzensen, Nicolas

Published
2022
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26. Cohort Profile: The Ontario Health Study (OHS).

Author

Kirsh, Victoria A, Skead, Kimberly, McDonald, Kelly, Kreiger, Nancy, Little, Julian, Menard, Karen, McLaughlin, John, Mukherjee, Sutapa, Palmer, Lyle J, Goel, Vivek, Purdue, Mark P, and Awadalla, Philip

Subjects
*RISK perception, *CANADIAN history, *MARIJUANA growing, *DROWSINESS, *HIV infections, *MENTAL health services, *FECAL occult blood tests
Abstract

Acknowledgements This study contracted ICES Data & Analytic Services and used de-identified data from the ICES Data Repository, which is managed by ICES with support from its funders and partners: Canada's Strategy for Patient-Oriented Research (SPOR), the Ontario SPOR Support Unit, the Canadian Institutes of Health Research and the Government of Ontario. Baseline data include personal and family health history; socio-demographic information; personal exposures to tobacco, alcohol and medications; and detailed information on ethnicity and country of origin (Box 1 and Table 2). The linking of Canada's rich collection of administrative health data with the cohort's data represents a powerful means to disseminate high-quality, timely data. The OHS does not hold administrative health data or cancer registry data. [Extracted from the article]

Published
2023
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32. Cohort Profile: The Ovarian Cancer Cohort Consortium (OC3)

Author

Townsend, Mary K, primary, Trabert, Britton, additional, Fortner, Renée T, additional, Arslan, Alan A, additional, Buring, Julie E, additional, Carter, Brian D, additional, Giles, Graham G, additional, Irvin, Sarah R, additional, Jones, Michael E, additional, Kaaks, Rudolf, additional, Kirsh, Victoria A, additional, Knutsen, Synnove F, additional, Koh, Woon-Puay, additional, Lacey, James V, additional, Langseth, Hilde, additional, Larsson, Susanna C, additional, Lee, I-Min, additional, Martínez, María Elena, additional, Merritt, Melissa A, additional, Milne, Roger L, additional, O’Brien, Katie M, additional, Orlich, Michael J, additional, Palmer, Julie R, additional, Patel, Alpa V, additional, Peters, Ulrike, additional, Poynter, Jenny N, additional, Robien, Kim, additional, Rohan, Thomas E, additional, Rosenberg, Lynn, additional, Sandin, Sven, additional, Sandler, Dale P, additional, Schouten, Leo J, additional, Setiawan, V Wendy, additional, Swerdlow, Anthony J, additional, Ursin, Giske, additional, van den Brandt, Piet A, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Wolk, Alicja, additional, Yuan, Jian-Min, additional, Zeleniuch-Jacquotte, Anne, additional, Tworoger, Shelley S, additional, and Wentzensen, Nicolas, additional

Published
2021
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33. The influence of an initial face-to-face meeting in an e-mail delivered physical activity intervention: a single-blind, randomized controlled trial

Author

Barisic, Andriana, Kreiger, Nancy, Leatherdale, Scott, Faulkner, Guy, Kirsh, Victoria, and Arbour-Nicitopoulos, Kelly

Subjects
Exercise -- Health aspects -- Technology application, Electronic mail systems -- Usage -- Health aspects, E-health -- Methods, Interpersonal communication -- Methods -- Health aspects, E-mail, Technology application, Health
Abstract

This paper examines the influence of an initial face-to face meeting in an e-mail delivered physical activity intervention. RMANCOVA was conducted to examine differences between e-mail and face-to-face arms in mean weekly steps adjusted for baseline steps, sex, and body mass index (BMI). Overall, 68 participants were analyzed face-to-face: (n = 35); e-mail: (n = 33). Participants in the face-to-face arm walked a greater number of steps each week; however, differences between arms pre- and post-intervention were not statistically significant (F (1, 60) = 0.31, p = .5796). These findings suggest that a physical activity intervention where initial instructions are delivered via e-mail is not statistically significantly different from a face-to-face approach., INTRODUCTION Regular physical activity can reduce the risk of developing several chronic diseases, including cardiovascular disease, diabetes, and some cancers (U.S. Department of Health and Human Services [USDHHS] 1996). To [...]

Published
2014

35. Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank

Author

Petrick, Jessica, McMenamin, Úna, Zhang, Xuehong, Zeleniuch-Jacquotte, Anne, Wactawski-Wende, Jean, Simon, Tracey G., Sinha, Rashmi, Sesso, Howard D., Schairer, Catherine, Rosenberg, Lynn, Rohan, Thomas E., Robien, Kim, Purdue, Mark P., Poynter, Jenny N., Palmer, Julie R., Lu, Yunxia, Linet, Martha S., Lee, I-Min, Koshiol, Jill, Kitahara, Cari M., Kirsh, Victoria A., Hoffman, Jonathan N., Graubard, Barry I., Giovannucci, Edward, Gaziano, J. Michael, Gapstur, Susan M., Freedman, Neal D., Florio, Andrea A., Chong, Dawn Q., Chen, Yu, Chan, Andrew T., Buring, Julie E., Freeman, Laura E. Beane, Bea, Jennifer W., Cardwell, Christopher R., Campbell, Peter T., and McGlynn, Katherine A.

Subjects
SDG 3 - Good Health and Well-being
Abstract

Background: Intrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. Cholangiocytes express both estrogen receptor-α and -β, and estrogens positively modulate cholangiocyte proliferation. Studies in women and men have reported higher circulating estradiol is associated with increased ICC risk, further supporting a hormonal etiology. However, no observational studies have examined the associations between exogenous hormone use and reproductive factors, as proxies of endogenous hormone levels, and risk of ICC. Methods: We harmonized data from 1,107,498 women who enrolled in 12 North American-based cohort studies (in the Liver Cancer Pooling Project, LCPP) and the UK Biobank between 1980-1998 and 2006-2010, respectively. Cox proportional hazards regression models were used to generate hazard ratios (HR) and 95% confidence internals (CI). Then, meta-analytic techniques were used to combine the estimates from LCPP (n=180 cases) and the UK Biobank (n=57 cases). Results: Hysterectomy was associated with a doubling of ICC risk (HR=1.98,95%CI:1.27–3.09), compared to women aged 50-54 at natural menopause. Long-term oral contraceptive use (9+ years) was associated with a 62% increased ICC risk (HR=1.62,95%CI:1.03–2.55). There was no association between ICC risk and other exogenous hormone use or reproductive factors. Conclusions: This study suggests that hysterectomy and long-term oral contraceptive use may be associated with an increased ICC risk.

Published
2020

36. Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project

Author

Jackson, Sarah S., Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Fraser, Gary E., Freedman, Neal D., Gapstur, Susan M., Gierach, Gretchen, Giles, Graham G., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F., Lan, Qing, Larsson, Susanna C., Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Petrick, Jessica L., Purdue, Mark P., Rohan, Thomas E., Sandin, Sven, Sandler, Dale P., Sawada, Norie, Shadyab, Aladdin H., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-, I, Zheng, Wei, McGlynn, Katherine A., Campbell, Peter T., Koshiol, Jill, Jackson, Sarah S., Adami, Hans-Olov, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Fraser, Gary E., Freedman, Neal D., Gapstur, Susan M., Gierach, Gretchen, Giles, Graham G., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kirsh, Victoria, Knutsen, Synnove F., Lan, Qing, Larsson, Susanna C., Lee, I-Min, Lee, Mei-Hsuan, Liao, Linda M., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O'Brien, Katie M., Petrick, Jessica L., Purdue, Mark P., Rohan, Thomas E., Sandin, Sven, Sandler, Dale P., Sawada, Norie, Shadyab, Aladdin H., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Weiderpass, Elisabete, Wolk, Alicja, Yang, Hwai-, I, Zheng, Wei, McGlynn, Katherine A., Campbell, Peter T., and Koshiol, Jill

Abstract

Background & Aims: Gallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear. Methods: We pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study. Results: During 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic bile duct cancer (IHBDC), 450 of extrahepatic bile duct cancer (EHBDC), and 261 of ampulla of Vater cancer (AVC) occurred. High parity was associated with risk of GBC (HR >= 5 vs. 0 births 1.72; 95% CI 1.25-2.38). Age at menarche (HR per year increase 1.15; 95% CI 1.06-1.24) was associated with GBC risk in Asian women while reproductive years were associated with GBC risk (HR per 5 years 1.13; 95% CI 1.04-1.22) in non-Asian women. Later age at menarche was associated with IHBDC (HR 1.19; 95% CI 1.09-1.31) and EHBDC (HR 1.11; 95% CI 1.01-1.22) in Asian women only. Conclusion: We observed an increased risk of GBC with increasing parity. Among Asian women, older age at menarche was associated with increased risk for GBC, IHBDC, and EHBDC, while increasing reproductive years was associated with GBC in non-Asian women. These results suggest that sex hormones have distinct effects on cancers across the biliary tract that vary by geography. Lay summary: Our findings show that the risk of gallbladder cancer is increased among women who have given birth (especially women with 5 or more children). In women from Asian countries, later age at menarche increases the risk of gallbladder cancer, intrahepat

Published
2020
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37. Adult weight change and premenopausal breast cancer risk : A prospective pooled analysis of data from 628,463 women

Author

Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie-Christine, Chen, Yu, Connor, Avonne E., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Ma, Huiyan, Milne, Roger L., Ozasa, Kotaro, Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Sacerdote, Carlotta, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., Swerdlow, Anthony J., Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie-Christine, Chen, Yu, Connor, Avonne E., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Ma, Huiyan, Milne, Roger L., Ozasa, Kotaro, Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Sacerdote, Carlotta, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., and Swerdlow, Anthony J.

Abstract

Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.

Published
2020
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38. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles : An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas

Abstract

Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies.

Published
2020
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39. The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles: an analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas

Published
2020

44. Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Liver Cancer Among Postmenopausal Women

Author

Petrick, Jessica L., primary, Florio, Andrea A., additional, Zhang, Xuehong, additional, Zeleniuch‐Jacquotte, Anne, additional, Wactawski‐Wende, Jean, additional, Van Den Eeden, Stephen K., additional, Stanczyk, Frank Z., additional, Simon, Tracey G., additional, Sinha, Rashmi, additional, Sesso, Howard D., additional, Schairer, Catherine, additional, Rosenberg, Lynn, additional, Rohan, Thomas E., additional, Purdue, Mark P., additional, Palmer, Julie R., additional, Linet, Martha S., additional, Liao, Linda M., additional, Lee, I‐Min, additional, Koshiol, Jill, additional, Kitahara, Cari M., additional, Kirsh, Victoria A., additional, Hofmann, Jonathan N., additional, Guillemette, Chantal, additional, Graubard, Barry I., additional, Giovannucci, Edward, additional, Gaziano, J. Michael, additional, Gapster, Susan M., additional, Freedman, Neal D., additional, Engel, Lawrence S., additional, Chong, Dawn Q., additional, Chen, Yu, additional, Chan, Andrew T., additional, Caron, Patrick, additional, Buring, Julie E., additional, Bradwin, Gary, additional, Beane Freeman, Laura E., additional, Campbell, Peter T., additional, and McGlynn, Katherine A., additional

Published
2020
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45. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., additional, O'Brien, Katie M., additional, Townsend, Mary K., additional, Fortner, Renée T., additional, Iversen, Edwin S., additional, Hartge, Patricia, additional, White, Emily, additional, Amiano, Pilar, additional, Arslan, Alan A., additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Buring, Julie E., additional, Dossus, Laure, additional, Fraser, Gary E., additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Gram, Inger T., additional, Harris, Holly R., additional, Bolton, Judith Hoffman, additional, Idahl, Annika, additional, Jones, Michael E., additional, Kaaks, Rudolf, additional, Kirsh, Victoria A., additional, Knutsen, Synnove F., additional, Kvaskoff, Marina, additional, Lacey, James V., additional, Lee, I-Min, additional, Milne, Roger L., additional, Onland-Moret, N. Charlotte, additional, Overvad, Kim, additional, Patel, Alpa V., additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Riboli, Elio, additional, Robien, Kim, additional, Rohan, Thomas E., additional, Sandler, Dale P., additional, Schairer, Catherine, additional, Schouten, Leo J., additional, Setiawan, Veronica W., additional, Swerdlow, Anthony J., additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, van den Brandt, Piet A., additional, Visvanathan, Kala, additional, Wilkens, Lynne R., additional, Wolk, Alicja, additional, Zeleniuch-Jacquotte, Anne, additional, and Wentzensen, Nicolas, additional

Published
2020
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46. Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women

Author

Schoemaker, Minouk J., primary, Nichols, Hazel B., additional, Wright, Lauren B., additional, Brook, Mark N., additional, Jones, Michael E., additional, O'Brien, Katie M., additional, Adami, Hans‐Olov, additional, Baglietto, Laura, additional, Bernstein, Leslie, additional, Bertrand, Kimberly A., additional, Boutron‐Ruault, Marie‐Christine, additional, Chen, Yu, additional, Connor, Avonne E., additional, Dossus, Laure, additional, Eliassen, A. Heather, additional, Giles, Graham G., additional, Gram, Inger T., additional, Hankinson, Susan E., additional, Kaaks, Rudolf, additional, Key, Timothy J., additional, Kirsh, Victoria A., additional, Kitahara, Cari M., additional, Larsson, Susanna C., additional, Linet, Martha, additional, Ma, Huiyan, additional, Milne, Roger L., additional, Ozasa, Kotaro, additional, Palmer, Julie R., additional, Riboli, Elio, additional, Rohan, Thomas E., additional, Sacerdote, Carlotta, additional, Sadakane, Atsuko, additional, Sund, Malin, additional, Tamimi, Rulla M., additional, Trichopoulou, Antonia, additional, Ursin, Giske, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Willett, Walter C., additional, Wolk, Alicja, additional, Zeleniuch‐Jacquotte, Anne, additional, Sandler, Dale P., additional, and Swerdlow, Anthony J., additional

Published
2020
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47. Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project

Author

Florio, Andrea A., primary, Campbell, Peter T., additional, Zhang, Xuehong, additional, Zeleniuch‐Jacquotte, Anne, additional, Wactawski‐Wende, Jean, additional, Smith‐Warner, Stephanie A., additional, Sinha, Rashmi, additional, Simon, Tracey G., additional, Sesso, Howard D., additional, Schairer, Catherine, additional, Rosenberg, Lynn, additional, Rohan, Thomas E., additional, Robien, Kim, additional, Renehan, Andrew G., additional, Purdue, Mark P., additional, Poynter, Jenny N., additional, Palmer, Julie R., additional, Newton, Christina C., additional, Lu, Yunxia, additional, Linet, Martha S., additional, Liao, Linda M., additional, Lee, I‐Min, additional, Koshiol, Jill, additional, Kitahara, Cari M., additional, Kirsh, Victoria A., additional, Hofmann, Jonathan N., additional, Graubard, Barry I., additional, Giovannucci, Edward, additional, Gaziano, John M., additional, Gapstur, Susan M., additional, Freedman, Neal D., additional, Demuth, Jane, additional, Chong, Dawn Q., additional, Chan, Andrew T., additional, Buring, Julie E., additional, Bradshaw, Patrick T., additional, Beane Freeman, Laura E., additional, McGlynn, Katherine A., additional, and Petrick, Jessica L., additional

Published
2019
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49. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

Author

Fortner, Renee T. Poole, Elizabeth M. Wentzensen, Nicolas A. and Trabert, Britton White, Emily Arslan, Alan A. Patel, V, Alpa and Setiawan, V. Wendy Visvanathan, Kala Weiderpass, Elisabete and Adami, Hans-Olov Black, Amanda Bernstein, Leslie and Brinton, Louise A. Buring, Julie Clendenen, V, Tess and Fournier, Agnes Fraser, Gary Gapstur, Susan M. Gaudet, Mia M. Giles, Graham G. Gram, Inger T. Hartge, Patricia and Hoffman-Bolton, Judith Idahl, Annika Kaaks, Rudolf Kirsh, Victoria A. Knutsen, Synnove Koh, Woon-Puay Lacey, Jr., James V. Lee, I-Min Lundin, Eva Merritt, Melissa A. and Milne, Roger L. Onland-Moret, N. Charlotte Peters, Ulrike and Poynter, Jenny N. Rinaldi, Sabina Robien, Kim Rohan, Thomas and Sanchez, Maria-Jose Schairer, Catherine Schouten, Leo J. and Tjonneland, Anne Townsend, Mary K. Travis, Ruth C. and Trichopoulou, Antonia van den Brandt, Piet A. Vineis, Paolo and Wilkens, Lynne Wolk, Alicja Yang, Hannah P. and Zeleniuch-Jacquotte, Anne Tworoger, Shelley S.

Abstract

Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to < 25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.

Published
2019

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