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1. Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2)

Author

Beyersdorf, F, Grügerny, M, Macharzina, R-R, Lechner, G, Menz, C, Schonhardt, S, Weinbeck, M, Greb, O, Otto, D, Winker, T, Berger, H, Poppert, H, Pütz, V, Haase, K, Bodechtel, U, Weiss, N, Bergert, H, Meyne, J, Groß, J, Botsch, A, Kruse, M, Gerdes, B, Reinbold, WD, Wuttig, H, Maier-Hasselmann, A, Segerer, M, Fuchs, H-H, Gass, S, Schultz, H, Groden, C, Niedergethman, M, Griebe, M, Rosenkranz, M, Beck, C, Thomalla, G, Zeumer, H, Jauß, M, Kneist, W, Kneist, M, Staudacher, T, Bernhard, A, Jost, D, Prey, N, Knippschild, J, Kastrup, O, Köhrmann, M, Frank, B, Bongers, V, Hoffmann, J, Kniemeyer, H-W, Knauth, M, Wasser, K, Stojanovic, T, Emmert, H, Tacke, J, Schwalbe, B, Nam, E-M, van Lengerich, U, Lowens, S, Gröschel, K, Uphaus, T, Gröschel, S, Boor, S, Dorweiler, B, Schmid, E, Henkes, H, Hupp, T, Singer, O, Hamann, G, Wagner-Heck, M, Kerth-Krick, S, Kilic, M, Huppert, P, Niederkorn, K, Fruhwirth, J, Klein, G, Pulkowski, U, Jöster, K, Wacks, J-H, Kloppmann, E, Vatankhah, B, Hopf-Jensen, S, Stolze, H, Müller-Hülsbeck, S, Walluscheck, KP, Schmitt, H-M, Grüger, A, Seemann, J, Tilahun, B, Dichgans, M, Wollenweber, F, Dörr, A, Zollver, A, Gäbel, G, Hedtmann, G, Kollmar, R, Claus, D, Petermann, C, Kirsch, S, Bosnjak, B, Heiß, J, Mühling, H, Wunderlich, S, Sabisch, PN, Gahn, G, Storck, M, Arnold, S, Fischer, U, Gralla, J, von Mering, M, Dißmann, R, Kirsch, D, Schmidauer, C, Waldenberger, P, Furtner, M, Kazarians, H, Breuer, P, Arning, C, Rieper, J, Schmidt, G, Arnold, M, Schroth, G, Weise, J, Zanow, J, Mayer, T, Töpper, R, Gross-Fengels, W, Daum, H, Dittrich, R, Ritter, M, Kasprzak, B, Torsello, G, Pohlmann, C, Brüning, R, Amiri, H, Ludwig, I, Blessing, E, Möhlenbruch, M, Crispin, A, Hofman, M, Müller, T, Reiff, Tilman, Eckstein, Hans-Henning, Mansmann, Ulrich, Jansen, Olav, Fraedrich, Gustav, Mudra, Harald, Böckler, Dittmar, Böhm, Michael, Brückmann, Hartmut, Debus, E. Sebastian, Fiehler, Jens, Mathias, Klaus, Ringelstein, E. Bernd, Schmidli, Jürg, Stingele, Robert, Zahn, Ralf, Zeller, Thomas, Niesen, Wolf-Dirk, Barlinn, Kristian, Binder, Andreas, Glahn, Jörg, and Ringleb, Peter Arthur

Published
2021
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2. Short-wave IR ultrafast fiber laser systems: Current challenges and prospective applications.

Author

Kirsch, D. C., Chen, S., Sidharthan, R., Chen, Y., Yoo, S., and Chernysheva, M.

Subjects
*FIBER lasers, *ULTRA-short pulsed lasers, *INDUSTRIAL research, *LASERS
Abstract

Ultrashort pulse generation at the short-wave infrared (SWIR) wavelength ranges from 1.6 to 2.5 μ m and together with benefits of the all-fiber design has transformed lasers into an essential tool for industrial, technological, scientific, environmental, and medical applications. With the development of pumping sources and fiber components, ultrafast SWIR fiber lasers have drawn exceptional research and industrial attention over the last decade, resulting in the achievement of comparable performance or even surpassing well-established near-IR sources. Exceptionally compact, highly stable, cost-effective, and maintenance-free ultrafast fiber lasers operating at the SWIR range are currently well on the way to be commercially employed. This invited Perspective article gives a comprehensive overview of the most significant achievements enabling ultrafast generation at SWIR, including up-to-date gain fibers and saturable absorbers, nonlinear process, and laser architectures. This article highlights the perspectives and strategies for further maturing of the field of SWIR fiber lasers and pathways for the improvement of the performance, overcoming existing bottlenecks and challenges toward reducing pulse durations, tunability of repetition rate, and power upscaling. The advancement of the ultrafast SWIR laser development is projected until the landscape of existing technologies, driven by these ultimate sources, and potential applications, emerging on the horizon. [ABSTRACT FROM AUTHOR]

Published
2020
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5. Akute Gefäßverschlüsse — interdisziplinäres Therapiespektrum

Author

Dörrler, J., Seip, G., Largiader, J., Schweiger, H., Raithel, D., Breuer, P., Schröder, A., Scherlitzky, L., Budde, U., Imig, H., Brachmann, K., Bettac, D., Falkenhahn, D., Junghans, R., Schmitz, R., Lorenz, J., Horstmann, R., Meffert, R., Heistermann, P., Hohlbach, G., Omlor, G., Müller, M., Walter, P., Meyer, A., Schimrigk, K., Feifel, G., Stimmel, F., Müller, J. H. A., Gruner, N., Metz, L., Steckmeier, B., Küffer, G., Szeimies, U., Parzhuber, A., Reininger, C., Schweiberer, L., Kirsch, D., Boettger, T., Junginger, T., Hartel, W., editor, and Hierholzer, G.

Published
1995
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6. FLASH Mechanisms Track (Oral Presentations) PRECLINICAL STUDIES WITH PROTON FLASH RADIOTHERAPY: BIOLOGICAL EFFECTS AND POTENTIAL MECHANISMS

Author

Verginadis, I., primary, Luo, L., additional, Martinez, C. Morral, additional, Foley, C., additional, Velalopoulou, A., additional, Kim, M., additional, Goia, D., additional, Reitman, Z., additional, Daniel, A., additional, Diffenderfer, E., additional, Dong, L., additional, Metz, J., additional, Kirsch, D., additional, Minn, A., additional, and Koumenis, C., additional

Published
2022
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9. Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2)

Author

Reiff, Tilman, primary, Eckstein, Hans-Henning, additional, Mansmann, Ulrich, additional, Jansen, Olav, additional, Fraedrich, Gustav, additional, Mudra, Harald, additional, Böckler, Dittmar, additional, Böhm, Michael, additional, Brückmann, Hartmut, additional, Debus, E. Sebastian, additional, Fiehler, Jens, additional, Mathias, Klaus, additional, Ringelstein, E. Bernd, additional, Schmidli, Jürg, additional, Stingele, Robert, additional, Zahn, Ralf, additional, Zeller, Thomas, additional, Niesen, Wolf-Dirk, additional, Barlinn, Kristian, additional, Binder, Andreas, additional, Glahn, Jörg, additional, Ringleb, Peter Arthur, additional, Beyersdorf, F, additional, Grügerny, M, additional, Macharzina, R-R, additional, Lechner, G, additional, Menz, C, additional, Schonhardt, S, additional, Weinbeck, M, additional, Greb, O, additional, Otto, D, additional, Winker, T, additional, Berger, H, additional, Poppert, H, additional, Pütz, V, additional, Haase, K, additional, Bodechtel, U, additional, Weiss, N, additional, Bergert, H, additional, Meyne, J, additional, Groß, J, additional, Botsch, A, additional, Kruse, M, additional, Gerdes, B, additional, Reinbold, WD, additional, Wuttig, H, additional, Maier-Hasselmann, A, additional, Segerer, M, additional, Fuchs, H-H, additional, Gass, S, additional, Schultz, H, additional, Groden, C, additional, Niedergethman, M, additional, Griebe, M, additional, Rosenkranz, M, additional, Beck, C, additional, Thomalla, G, additional, Zeumer, H, additional, Jauß, M, additional, Kneist, W, additional, Kneist, M, additional, Staudacher, T, additional, Bernhard, A, additional, Jost, D, additional, Prey, N, additional, Knippschild, J, additional, Kastrup, O, additional, Köhrmann, M, additional, Frank, B, additional, Bongers, V, additional, Hoffmann, J, additional, Kniemeyer, H-W, additional, Knauth, M, additional, Wasser, K, additional, Stojanovic, T, additional, Emmert, H, additional, Tacke, J, additional, Schwalbe, B, additional, Nam, E-M, additional, van Lengerich, U, additional, Lowens, S, additional, Gröschel, K, additional, Uphaus, T, additional, Gröschel, S, additional, Boor, S, additional, Dorweiler, B, additional, Schmid, E, additional, Henkes, H, additional, Hupp, T, additional, Singer, O, additional, Hamann, G, additional, Wagner-Heck, M, additional, Kerth-Krick, S, additional, Kilic, M, additional, Huppert, P, additional, Niederkorn, K, additional, Fruhwirth, J, additional, Klein, G, additional, Pulkowski, U, additional, Jöster, K, additional, Wacks, J-H, additional, Kloppmann, E, additional, Vatankhah, B, additional, Hopf-Jensen, S, additional, Stolze, H, additional, Müller-Hülsbeck, S, additional, Walluscheck, KP, additional, Schmitt, H-M, additional, Grüger, A, additional, Seemann, J, additional, Tilahun, B, additional, Dichgans, M, additional, Wollenweber, F, additional, Dörr, A, additional, Zollver, A, additional, Gäbel, G, additional, Hedtmann, G, additional, Kollmar, R, additional, Claus, D, additional, Petermann, C, additional, Kirsch, S, additional, Bosnjak, B, additional, Heiß, J, additional, Mühling, H, additional, Wunderlich, S, additional, Sabisch, PN, additional, Gahn, G, additional, Storck, M, additional, Arnold, S, additional, Fischer, U, additional, Gralla, J, additional, von Mering, M, additional, Dißmann, R, additional, Kirsch, D, additional, Schmidauer, C, additional, Waldenberger, P, additional, Furtner, M, additional, Kazarians, H, additional, Breuer, P, additional, Arning, C, additional, Rieper, J, additional, Schmidt, G, additional, Arnold, M, additional, Schroth, G, additional, Weise, J, additional, Zanow, J, additional, Mayer, T, additional, Töpper, R, additional, Gross-Fengels, W, additional, Daum, H, additional, Dittrich, R, additional, Ritter, M, additional, Kasprzak, B, additional, Torsello, G, additional, Pohlmann, C, additional, Brüning, R, additional, Amiri, H, additional, Ludwig, I, additional, Blessing, E, additional, Möhlenbruch, M, additional, Crispin, A, additional, Hofman, M, additional, and Müller, T, additional

Published
2021
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11. The social impacts of the Circular Economy in the Global South: Circularity strategies and shared value creation in fashion social enterprises

Author

Kirsch, D., Bauwens, Thomas (Thesis Advisor), Kirsch, D., and Bauwens, Thomas (Thesis Advisor)

Abstract

The current fashion industry, based on linear business approaches, is known for being broken and causing environmental harm and social scandals, especially in the Global South. The Circular Economy (CE) concept is much-heralded among policy-makers, scholars and industry professionals as a promising pathway towards a more sustainable state in the apparel sector. Nevertheless, until now, research combining CE to social business approaches in the fashion industry is lacking, and thus it remains vague in which way fashion business models could create value for people, planet and profit. This research was based on a deductively and inductively created framework including the typology of three different SE business models by Alter (2007), circular practices in the fashion industry and existing literature on shared value creation including 12 social value type indicators and 7 brand value type indicators. The framework was applied on different circular fashion brands using one of the three SE business models selected for this research: embedded (being a SE in the Global South), integrated (being a brand based in the Global North and producing with a SE in the Global South) and external (being a brand based in the Global North and funding a social initiative in the Global South). The aim was first to assess which circular strategies are adopted by these different SE business models and secondly to analyze what types of value can be created for people in the Global South as well as for the brands themselves by applying these SE business approaches. Considering the circular strategies, the results show that the embedded SE business model uses mostly upcycling, the integrated SE business model recycling and upcycling, and the external SE business model only recycling. Regarding the shared value creation, all three SE Business models create significant value for the people in the Global South. In contrast, for the brand value types, only the embedded and integrated SE business

Published
2020

21. High-performance liquid chromatography and laser desorption/ionization mass spectrometry of retinyl esters

Author

Wingerath, T., Kirsch, D., Spengler, B., Kaufmann, R., and Stahl, W.

Subjects
High performance liquid chromatography -- Usage, Secondary ion mass spectrometry -- Usage, Esters -- Analysis, Rosin-oil -- Analysis, Chemistry
Abstract

Laser desorption/ionization mass spectrometry (LDI-MS) at 337 nm laser wavelength was used to analyze retinol and several long-chain fatty acid esters of retinol. Employing this ionization technique helped to overcome the inherent problems resulting from thermal instability of retinyl esters which render this group of compounds rather difficult for standard ionization techniques. Mass spectra were recorded with a linear time-of-flight instrument in positive ion mode. Under these conditions, retinyl esters formed radical molecular ions ([M.sup.[center dot]+]) and in addition fragmented by elimination of the fatty acyl chain to uniformely form a peak at m/z = 269 u. The elimination of carbon dioxide was also observed in the spectra. The method is suitable to identify specific retinyl esters in complex mixtures of these compounds. A gradient reversed-phase high-performance liquid chromatography (HPLC) is described for the separation of retinol and 15 related fatty acid esters within 28 min. HPLC was applied to separate retinyl esters from rat liver extracts. The LDI mass spectrum of the collected HPLC fraction of rat liver extract showed the molecular parent ions of retinyl myristate, pentadecanoate, palmitoleate, palmitate, heptadecanoate, linoleate, oleate, stearate, and 3,4-didehydroretinyl palmitate. LDI-MS was found to be more appropriate than matrix-assisted laser desorption/ionization for the described analytical task.

Published
1997

26. 3:18 PM Abstract No. 35 ■ DISTINGUISHED ABSTRACT Lymphopenia selects poor DEB-TACE response in transplant waitlist patients: prospective, single-center, observational study

Author

Sandow, T., primary, Thevenot, P., additional, Gimenez, J., additional, Arndt, S., additional, Nunez, K., additional, DeVun, D., additional, Gulotta, P., additional, Ramalingam, V., additional, Gilbert, P., additional, Kirsch, D., additional, Bohorquez, H., additional, Kay, D., additional, and Cohen, A., additional

Published
2018
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27. 3:27 PM Abstract No. 274 A prospective study of lung shunt fraction as a determinant of DEB-TACE response and metastasis and determinants of lung shunt fraction

Author

Arndt, S., primary, Sandow, T., additional, Kay, D., additional, DeVun, D., additional, Gulotta, P., additional, Kirsch, D., additional, Ramalingam, V., additional, Nunez, K., additional, Bohorquez, H., additional, Cohen, A., additional, Thevenot, P., additional, and Gimenez, J., additional

Published
2018
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28. 3:00 PM Abstract No. 33 Pre-TACE immune status correlates with treatment response and necrosis rates in HCC as a bridge to liver transplant

Author

Goldman, D., primary, Sandow, T., additional, Gimenez, J., additional, Arndt, S., additional, Thevenot, P., additional, Nunez, K., additional, DeVun, D., additional, Gulotta, P., additional, Ramalingam, V., additional, Gilbert, P., additional, Kirsch, D., additional, Bohorquez, H., additional, Galliano, G., additional, Cohen, A., additional, and Kay, D., additional

Published
2018
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31. A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Chemistry, Griffith, Linda G, Bawendi, Moungi G, Whitley, M. J., Cardona, D. M., Lazarides, A. L., Spasojevic, I., Ferrer, J. M., Lee, C.-L., Snuderl, M., Blazer, D. G., Hwang, E. S., Greenup, R. A., Mosca, P. J., Mito, J. K., Cuneo, K. C., Larrier, N. A., OReilly, E. K., Riedel, R. F., Eward, W. C., Strasfeld, D. B., Fukumura, D., Lee, W. D., Kirsch, D. G., Brigman, B. E., Cahill, Joan, Jain, Rakesh J., Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Chemistry, Griffith, Linda G, Bawendi, Moungi G, Whitley, M. J., Cardona, D. M., Lazarides, A. L., Spasojevic, I., Ferrer, J. M., Lee, C.-L., Snuderl, M., Blazer, D. G., Hwang, E. S., Greenup, R. A., Mosca, P. J., Mito, J. K., Cuneo, K. C., Larrier, N. A., OReilly, E. K., Riedel, R. F., Eward, W. C., Strasfeld, D. B., Fukumura, D., Lee, W. D., Kirsch, D. G., Brigman, B. E., Cahill, Joan, and Jain, Rakesh J.

Abstract

Local recurrence is a common cause of treatment failure for patients with solid tumors. Intraoperative detection of microscopic residual cancer in the tumor bed could be used to decrease the risk of a positive surgical margin, reduce rates of reexcision, and tailor adjuvant therapy. We used a protease-activated fluorescent imaging probe, LUM015, to detect cancer in vivo in a mouse model of soft tissue sarcoma (STS) and ex vivo in a first-in-human phase 1 clinical trial. In mice, intravenous injection of LUM015 labeled tumor cells, and residual fluorescence within the tumor bed predicted local recurrence. In 15 patients with STS or breast cancer, intravenous injection of LUM015 before surgery was well tolerated. Imaging of resected human tissues showed that fluorescence from tumor was significantly higher than fluorescence from normal tissues. LUM015 biodistribution, pharmacokinetic profiles, and metabolism were similar in mouse and human subjects. Tissue concentrations of LUM015 and its metabolites, including fluorescently labeled lysine, demonstrated that LUM015 is selectively distributed to tumors where it is activated by proteases. Experiments in mice with a constitutively active PEGylated fluorescent imaging probe support a model where tumor-selective probe distribution is a determinant of increased fluorescence in cancer. These co-clinical studies suggest that the tumor specificity of protease-activated imaging probes, such as LUM015, is dependent on both biodistribution and enzyme activity. Our first-in-human data support future clinical trials of LUM015 and other protease-sensitive probes.

Published
2017

33. Statistical analysis of a self-starting linear Mamyshev oscillator with two symmetric Tm-doped fiber gain sections

Author

Kirsch Dennis C., Likhachev Mikhail E., Aleshkina Svetlana S., Yashkov Mikhail V., and Chernysheva Maria

Subjects
Physics, QC1-999
Abstract

An innovative concept to achieve a self-starting, all-fibre and all-normal dispersion Mamyshev oscillator for the 1.9 μm wavelength domain is explored. A machine-aided approach is chosen to investigate systematically the constrictions between filter offset, output coupling ratio and pump power.

Published
2024
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44. A Comparison of the Success Rates of Resident and Attending Strabismus Surgery

Author

Kirsch D, Repka Mx, Raab E, Wisnicki Hj, Loupe Dn, Nath A, and Hamad Gg

Subjects
medicine.medical_specialty, Adolescent, Population, Statistical difference, Postoperative Complications, Medical Staff, Hospital, Prism diopters, Humans, Medicine, Child, education, education.field_of_study, Education, Medical, business.industry, General surgery, Suture Techniques, Internship and Residency, General Medicine, Strabismus, Ophthalmology, Treatment Outcome, Pediatrics, Perinatology and Child Health, Clinical Competence, business, Residency training, Follow-Up Studies, Strabismus surgery
Abstract

Residency training involves surgery by resident surgeons at various levels of experience and proficiency, supervised by an experienced attending physician. We reviewed the results of strabismus surgery performed at four institutions with two residency training programs. Five hundred twenty-two cases with follow up greater than 6 weeks were evaluated. These cases included 315 attending procedures and 207 resident procedures under direct attending supervision. Success was defined as a strabismic deviation of 8 prism diopters or less. Average postoperative follow-up was 57 weeks and did not differ between groups. There was no statistical difference between the resident success rate of 58% (121/207) and the attending success rate of 69% (217/315) after adjusting for population differences. The average final deviation of the patients postoperatively was 7 Δ for the attending group and 10 Δ for the resident group. Amblyopia was significantly more frequent in the resident cases (P < .001). Adjustable sutures were used significantly more often in attending cases (P < .0001). This study supports the premise that resident strabismus surgery is as successful as attending surgery.

Published
1993
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47. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-ß-catenin-mediated intestinal tumor growth and regeneration

Author

Phesse, T., Buchert, M., Stuart, E., Flanagan, D., Faux, M., Afshar-Sterle, S., Walker, F., Zhang, H., Nowell, C., Jorissen, R., Tan, C., Hirokawa, Y., Eissmann, M., Poh, A., Malaterre, J., Pearson, H., Kirsch, D., Provero, P., Poli, V., Ramsay, R., Sieber, O., Burgess, A., Huszar, D., Vincan, Elizabeth, Ernst, M., Phesse, T., Buchert, M., Stuart, E., Flanagan, D., Faux, M., Afshar-Sterle, S., Walker, F., Zhang, H., Nowell, C., Jorissen, R., Tan, C., Hirokawa, Y., Eissmann, M., Poh, A., Malaterre, J., Pearson, H., Kirsch, D., Provero, P., Poli, V., Ramsay, R., Sieber, O., Burgess, A., Huszar, D., Vincan, Elizabeth, and Ernst, M.

Abstract

Copyright © 2014 American Association for the Advancement of Science. All Rights Reserved. Most colon cancers arise from somatic mutations in the tumor suppressor gene APC (adenomatous polyposis coli), and these mutations cause constitutive activation of the Wnt-to-ß-catenin pathway in the intestinal epithelium. Because Wnt-ß-catenin signaling is required for homeostasis and regeneration of the adult intestinal epithelium, therapeutic targeting of this pathway is challenging. We found that genetic activation of the cytokine-stimulated pathway mediated by the receptor gp130, the associated Jak (Janus kinase) kinases, and the transcription factor Stat3 (signal transducer and activator of transcription 3) was required for intestinal regeneration in response to irradiation-induced damage in wild-type mice and for tumorigenesis in Apc-mutant mice. Systemic pharmacological or partial genetic inhibition of gp130-Jak-Stat3 signaling suppressed intestinal regeneration, the growth of tumors in Apc-mutant mice, and the growth of colon cancer xenografts. The growth of Apc-mutant tumors depended on gp130-Jak-Stat3 signaling for induction of the polycomb repressor Bmi-1, and the associated repression of genes encoding the cell cycle inhibitors p16 and p21. However, suppression of gp130-Jak-Stat3 signaling did not affect Wnt-ß-catenin signaling or homeostasis in the intestine. Thus, these data not only suggest a molecular mechanism for how the gp130-Jak-Stat3 pathway can promote cancer but also provide a rationale for therapeutic inhibition of Jak in colon cancer.

Published
2014

50. Combining Targeted Agents With Modern Radiotherapy in Soft Tissue Sarcomas

Author

Wong, P., primary, Houghton, P., additional, Kirsch, D. G., additional, Finkelstein, S. E., additional, Monjazeb, A. M., additional, Xu-Welliver, M., additional, Dicker, A. P., additional, Ahmed, M., additional, Vikram, B., additional, Teicher, B. A., additional, Coleman, C. N., additional, Machtay, M., additional, Curran, W. J., additional, and Wang, D., additional

Published
2014
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