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1. Deaths Associated with Pediatric Hepatitis of Unknown Etiology, United States, October 2021-June 2023

Author

Almendares, Olivia, Baker, Julia M., Sugerman, David E., Parashar, Umesh D., Reagan-Steiner, Sarah, Kirking, Hannah L., Gastanaduy, Paul A., and Tate, Jacqueline E.

Subjects
United States. Centers for Disease Control and Prevention, Children -- Diseases, Hepatitis -- Prevention -- Development and progression, Pediatrics, Liver, Adenoviruses, Diseases -- Causes and theories of causation, Health
Abstract

During October-November 2021, clinicians at a single children's hospital in Alabama, USA, identified 5 previously healthy children with acute hepatitis of unknown etiology who tested positive for adenovirus species F, [...]

Published
2024
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2. Identification of Large Adenovirus Infection Outbreak at University by Multipathogen Testing, South Carolina, USA, 2022

Author

Tori, Marco E., Chontos-Komorowski, Judith, Stacy, Jason, Lamson, Daryl M., George, Kirsten St., Lail, Avril T., Stewart- Grant, Heather A., Bell, Linda J., Kirking, Hannah L., and Hsu, Christopher H.

Subjects
United States. Centers for Disease Control and Prevention, Diseases -- Prevention -- South Carolina, Adenoviruses, Health
Abstract

Human adenovirus (HAdV) infections can cause a range of symptoms but most commonly result in respiratory illnesses (1). Most HAdV infections are not clinically severe; however, more serious illness can [...]

Published
2024
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3. Adeno-associated virus type 2 in US children with acute severe hepatitis

Author

Servellita, Venice, Sotomayor Gonzalez, Alicia, Lamson, Daryl M, Foresythe, Abiodun, Huh, Hee Jae, Bazinet, Adam L, Bergman, Nicholas H, Bull, Robert L, Garcia, Karla Y, Goodrich, Jennifer S, Lovett, Sean P, Parker, Kisha, Radune, Diana, Hatada, April, Pan, Chao-Yang, Rizzo, Kyle, Bertumen, J Bradford, Morales, Christina, Oluniyi, Paul E, Nguyen, Jenny, Tan, Jessica, Stryke, Doug, Jaber, Rayah, Leslie, Matthew T, Lyons, Zin, Hedman, Hayden D, Parashar, Umesh, Sullivan, Maureen, Wroblewski, Kelly, Oberste, M Steven, Tate, Jacqueline E, Baker, Julia M, Sugerman, David, Potts, Caelin, Lu, Xiaoyan, Chhabra, Preeti, Ingram, L Amanda, Shiau, Henry, Britt, William, Gutierrez Sanchez, Luz Helena, Ciric, Caroline, Rostad, Christina A, Vinjé, Jan, Kirking, Hannah L, Wadford, Debra A, Raborn, R Taylor, St. George, Kirsten, and Chiu, Charles Y

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Hepatitis, Infectious Diseases, Genetics, Clinical Research, Liver Disease, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Child, Humans, Acute Disease, Adenovirus Infections, Human, Coinfection, Dependovirus, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Herpesvirus 6, Human, Enterovirus A, Human, Helper Viruses, Pediatric Hepatitis of Unknown Etiology Working Group, General Science & Technology
Abstract

As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have been reported from 35 countries, including the USA1,2. Previous studies have found human adenoviruses (HAdVs) in the blood from patients in Europe and the USA3-7, although it is unclear whether this virus is causative. Here we used PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing to analyse samples from 16 HAdV-positive cases from 1 October 2021 to 22 May 2022, in parallel with 113 controls. In blood from 14 cases, adeno-associated virus type 2 (AAV2) sequences were detected in 93% (13 of 14), compared to 4 (3.5%) of 113 controls (P

Published
2023

4. SARS-CoV-2 Viral Shedding and Rapid Antigen Test Performance--Respiratory Virus Transmission Network, November 2022-May 2023

Author

Smith-Jeffcoat, Sarah E., Mellis, Alexandra M., Grijalva, Carlos G., Talbot, H. Keipp, Schmitz, Jonathan, Lutrick, Karen, Ellingson, Katherine D., Stockwell, Melissa S., McLaren, Son H., Nguyen, Huong Q., Rao, Suchitra, Asturias, Edwin J., Davis-Gardner, Meredith E., Suthar, Mehul S., and Kirking, Hannah L.

Subjects
United States. Food and Drug Administration, Antigen-antibody reactions -- Comparative analysis -- Health aspects, Medical tests -- Comparative analysis -- Health aspects, Antiviral agents -- Health aspects -- Comparative analysis, Health care industry -- Comparative analysis -- Health aspects, Antigens -- Comparative analysis -- Health aspects, Infection -- Comparative analysis -- Health aspects, Health care industry, Health
Abstract

Introduction SARS-CoV-2 rapid antigen tests were developed and received Food and Drug Administration Emergency Use Authorization early during the COVID-19 pandemic. * These tests were initially rolled out broadly in [...]

Published
2024

5. Paediatric acute hepatitis of unknown aetiology: a national surveillance investigation in the USA during 2021 and 2022

Author

Burke, Rachel M., Burnett, Eleanor, Vega, Everardo M., Lu, Xiaoyan, Coughlin, Melissa M., Bankamp, Bettina, Leitgeb, Brooke, Estetter, Lindsey Blythe Coulter, Silva-Flannery, Lucinia, Martines, Roosecelis B., Wadford, Debra A., Morales, Christina, Pan, Chao-Yang, Popowich, Michael, Lamson, Daryl M., St. George, Kirsten, Cebelinski, Elizabeth, Panek, Anna, Ingram, L. Amanda, Ayers-Millsap, Stephanie, Dulski, Theresa, Reed, Tameika, Sietsema, Lydia, Savella, Adrian, Derby, Mary P., Matthews, James, Abe, Kentaro F., Rizzo, Kyle R., Stockman, Lauren J., Dao, Bonnie L., Burakoff, Alexis, Tapay, Diana, Kacka, Michael, Gacek, Paul, Phan, Quyen, Langer, Christina, Kupferman, Nikki, Gent, Ashley, Dessi, Dalton, Tobin-D'Angelo, Melissa, Gandhi, Ami, Carter, Kris K., Leslie, Matthew T., Saathoff-Huber, Lori, Stone, Nicole, Hodge, Bethany, Odegard, Amanda, Hand, Julia, Jacoboski, Juliana, Nguyen, Christine, Manchester, Chloe, Smith, Emer, Ladisky, Macey, Brousseau, Geoff, Grilli, Genny, Freitas, Mari, Berkley, Alexandra, Do, Michael, Hanson, Jennifer, Boutwell, Carla, VanderBusch, Lindsey, Renton, Shari, Goebel, Rachel, Sato, Alice I., Donahue, Matthew, Julian, Derek, Mallory, Krystle, Bridges, Deanna, Thomas, Deepam, Stadelman, Anna M, Gehre, Mika, Holzinger, Nora, Peek-Bullock, Melissa, Sepcic, Victoria, Ghadge, Nitin M, Byun, Youjung, Anderson, Bridget J., Balan, Dominique, Antwi, Mike, Taylor, Brandi, Dewart, Courtney, Wayman, Ashlyn, Solberg, Marie, Lund, Hannah, Plipat, Nottasorn, Wallace, Jennifer L., Cardona, Iris, Rodríguez, Melissa Marzán, Berns, Abby L., McAuley, Patricia, Campbell, Chelsea, Clayton, Joshua, Schultz, Jessica, Wallace, Ryan, Salmanson, Amelia Prebish, Saady, Dawn, Heaton, Tabatha, Carlson, Kimberly, Dodd, Amanda, Haupt, Thomas, McLemore, Stephanie D., del Rosario, Maria C., Cates, Jordan, Baker, Julia M, Almendares, Olivia, Balachandran, Neha, McKeever, Erin R, Kambhampati, Anita K, Cubenas, Caelin, Vinjé, Jan, Cannon, Jennifer L, Chhabra, Preeti, Freeman, Brandi, Reagan-Steiner, Sarah, Bhatnagar, Julu, Gastañaduy, Paul A, Kirking, Hannah L, Sugerman, David, Parashar, Umesh D, and Tate, Jacqueline E

Published
2023
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6. Is Symptom Screening Useful for Identifying COVID-19 Infection in School Settings? Georgia, USA

Author

Swanson, Megan, Hast, Marisa, Burnett, Eleanor, Oraka, Emeka, Kimball, Anne, Morris, Elana, Marcet, Paula L., Almendares, Olivia, Franklin, Rachel, Mehari, Lemlem, McCloud, Jazmyn, Kirking, Hannah L., Tate, Jacqueline E., and Scott, Colleen

Abstract

This study's goal was to characterize the utility of symptom screening in staff and students for COVID-19 identification and control of transmission in a school setting. We conducted a secondary analysis of cross-sectional data for staff, students and associated household members in a Georgia school district exposed to COVID-19 cases who received RT-PCR testing and symptom monitoring. Among positive contacts, 30/49 (61%) of students and 1/6 (17%) of staff reported no symptoms consistent with COVID-19. Symptom sensitivity was 30% in elementary students and 42% in middle/high students. Fifty-three percent (10/19) of symptomatic positive contacts had at least one household member test positive for SARS-CoV-2 compared with 50% (10/20) of asymptomatic positive contacts. The absence of symptoms in children is not indicative of a lack of SARS-CoV-2 infection or reduced risk of infection for associated household members. Testing all close contacts of people with COVID-19 in schools is needed to interrupt transmission networks.

Published
2021
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7. Transmission potential of vaccinated and unvaccinated persons infected with the SARS-CoV-2 Delta variant in a federal prison, July—August 2021

Author

Salvatore, Phillip P., Lee, Christine C., Sleweon, Sadia, McCormick, David W., Nicolae, Lavinia, Knipe, Kristen, Dixon, Tom, Banta, Robert, Ogle, Isaac, Young, Cristen, Dusseau, Charles, Salmonson, Shawn, Ogden, Charles, Godwin, Eric, Ballom, TeCora, Rhodes, Tara, Wynn, Nhien Tran, David, Ebenezer, Bessey, Theresa K., Kim, Gimin, Suppiah, Suganthi, Tamin, Azaibi, Harcourt, Jennifer L., Sheth, Mili, Lowe, Luis, Browne, Hannah, Tate, Jacqueline E., Kirking, Hannah L., and Hagan, Liesl M.

Published
2023
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8. Behaviors Associated With Household Transmission of SARS-CoV-2 in California and Colorado, January 2021–April 2021

Author

Namageyo-Funa, Apophia, Ruffin, Jasmine D., Killerby, Marie E., Jalloh, Mohamed F., Scott, Colleen, Lindell, Kristine, Silver, Margaret, Matanock, Almea, Soto, Raymond A., Donnelly, Marisa A.P., Schwartz, Noah G., Chuey, Meagan R., Chu, Victoria T., Beatty, Mark E., Totten, Sarah Elizabeth, Hudziec, Meghan M., Tate, Jacqueline E., Kirking, Hannah L., and Hsu, Christopher H.

Published
2022
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9. Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures

Author

Currie, Dustin W., Shah, Melisa M., Salvatore, Phillip P., Ford, Laura, Whaley, Melissa J., Meece, Jennifer, Ivacic, Lynn, Thornburg, Natalie J., Tamm, Azaibi, Harcourt, Jennifer L., Folster, Jennifer, Medrzycki, Magdalena, Jain, Shilpi, Wong, Phili, Goffard, Kimberly, Gieryn, Douglas, Kahrs, Juliana, Langolf, Kimberly, Zochert, Tara, Hsu, Christopher H., Kirking, Hannah L., and Tate, Jacqueline E.

Subjects
Immune system -- Testing, Polymerase chain reaction -- Comparative analysis -- Usage, Health
Abstract

Antigen platforms for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic testing have rapid turnaround time, are easy to use, and are less expensive than real-time reverse transcription PCR (RT-PCR) [...]

Published
2022
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10. A cohort study measuring SARS-CoV-2 seroconversion and serial viral testing in university students

Author

Lee, Christine C., Segaloff, Hannah E., Cole, Devlin, Rosenblum, Hannah G., Morgan, Clint N., Somers, Tarah, Desamu-Thorpe, Rodel, Foster, Monique A., Currie, Dustin, Ruff, Jeanne, Payne, David, Whyte, Thomas J., Abedi, Glen R., Bigouette, John Paul, Kahrs, Juliana, Langolf, Kimberly, Remington, Patrick, Sterkel, Alana, Kelly, Patrick, Westergaard, Ryan P., Bateman, Allen C., Hsu, Christopher H., Tate, Jacqueline E., and Kirking, Hannah L.

Published
2022
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11. Prevalence of risk behaviors and correlates of SARS-CoV-2 positivity among in-school contacts of confirmed cases in a Georgia school district in the pre-vaccine era, December 2020–January 2021

Author

Hast, Marisa, Swanson, Megan, Scott, Colleen, Oraka, Emeka, Espinosa, Catherine, Burnett, Eleanor, Kukielka, Esther A., Rice, Marion E., Mehari, Lemlem, McCloud, Jazmyn, Miller, Danielle, Franklin, Rachel, Tate, Jacqueline E., Kirking, Hannah L., and Morris, Elana

Published
2022
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13. Lack of Serologic Evidence of Infection Among Health Care Personnel and Other Contacts of First 2 Confirmed Patients With COVID-19 in Illinois, 2020

Author

McPherson, Tristan D., Ghinai, Isaac, Binder, Alison M., Freeman, Brandi D., Snelling, Chantel Hoskin, Hunter, Jennifer C., Anderson, Kristin M., Davenport, Polly, Rudd, Deborah L., Zafer, Mujeeb, Christiansen, Demian, Joshi, Kiran, Rubin, Rachel, Black, Stephanie R., Fricchione, Marielle J., Pacilli, Massimo, Walblay, Kelly A., Korpics, Jacqueline, Moeller, Darcie, Quartey-Kumapley, Pearl, Wang, Chen, Charles, E. Matt, Kauerauf, Judy, Patel, Megan T., Disari, Vishal S., Fischer, Marc, Jacobs, Max W., Lester, Sandra N., Midgley, Claire M., Rasheed, Mohammed Ata Ur, Reese, Heather E., Verani, Jennifer R., Wallace, Megan, Watson, John T., Thornburg, Natalie J., Layden, Jennifer E., and Kirking, Hannah L.

Published
2021

14. Early Detection and Surveillance of the SARS-CoV-2 Variant BA.2.86--Worldwide, July-October 2023

Author

Lambrou, Anastasia S., South, Erin, Ballou, Eliza S., Paden, Clinton R., Fuller, James A., Bart, Stephen M., Butryn, Deena M., Novak, Ryan T., Browning, Sean D., Kirby, Amy E., Welsh, Rory M., Cornforth, Daniel M., MacCannell, Duncan R., Friedman, Cindy R., Thornburg, Natalie J., Hall, Aron J., Hughes, Laura J., Mahon, Barbara E., Daskalakis, Demetre C., Shah, Nirav D., Jackson, Brendan R., and Kirking, Hannah L.

Subjects
Wastewater -- Health aspects, Risk assessment -- Health aspects, Travelers -- Health aspects, Public health -- Health aspects, Health
Abstract

Introduction CDC uses a diverse, multicomponent surveillance approach to track the emergence of new and potentially significant SARS-CoV-2 variants across the United States and globally. These surveillance systems include genomic, [...]

Published
2023

16. Behaviors and attitudes of college students during an academic semester at two Wisconsin universities during the COVID-19 pandemic.

Author

Rosenblum, Hannah G., Segaloff, Hannah E., Cole, Devlin, Lee, Christine C., Currie, Dustin W., Abedi, Glen R., Remington, Patrick L., Kelly, G. Patrick, Pitts, Collin, Langolf, Kimberly, Kahrs, Juliana, Leibold, Kurt, Westergaard, Ryan P., Hsu, Christopher H., Kirking, Hannah L., and Tate, Jacqueline E.

Subjects
REPEATED measures design, WORK, RESEARCH funding, FOOD consumption, RESTAURANTS, RISK-taking behavior, UNIVERSITIES & colleges, DESCRIPTIVE statistics, SURVEYS, MOTIVATION (Psychology), HEALTH behavior, MEDICAL masks, PSYCHOLOGY of college students, STUDENT attitudes, COMPARATIVE studies, ALCOHOL drinking, COVID-19 pandemic, COVID-19, SOCIAL distancing
Abstract

Characterize college student COVID-19 behaviors and attitudes during the early pandemic. Participants: Students on two university campuses in Wisconsin. Surveys administered in September and November 2020. Few students (3–19%) participated in most in-person activities during the semester, with eating at restaurants as the exception (72–80%) and attending work (35%) and parties (33%) also reported more frequently. The majority wore masks in public (94–99%), but comparatively fewer (42%) did so at parties. Mask-wearing at parties decreased from September to November (p < 0.05). Students attending parties, or consuming more alcohol, were less concerned and more likely to take COVID-19-associated risks. Students were motivated to adhere to COVID-19 prevention measures but gathered socially. Though there was frequent public masking, mask-wearing at parties declined in November and may represent pandemic fatigue. High-yield strategies for decreasing viral spread may include changing masking social norms and engaging with students about creative risk-reduction strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Coronavirus Disease Contact Tracing Outcomes and Cost, Salt Lake County, Utah, USA, March-May 2020

Author

Fields, Victoria L., Kracalik, Ian T., Carthel, Christina, Lopez, Adriana, Schwartz, Amy, Lewis, Nathaniel M., Bray, Mackenzie, Claflin, Carlene, Jorgensen, Kilee, Khong, Ha, Richards, Walter, Risk, Ilene, Smithee, Maureen, Clawson, Madison, Booth, Lee Cherie, Scribellito, Tara, Lowry, Jason, Huynh, Jessica, Davis, Linda, Birch, Holly, Tran, Tiffany, Walker, Joseph, Fry, Alicia, Hall, Aron, Baker, Jodee, Pevzner, Eric, Dunn, Angela C., Tate, Jacqueline E., Kirking, Hannah L., Kiphibane, Tair, and Tran, Cuc H.

Subjects
Salt Lake County, Utah -- Health aspects, Epidemics -- Statistics -- Control -- United States, Contact tracing -- Methods -- Economic aspects, Health
Abstract

By July 2021, >33 million cases of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were documented in the United States, and most cases involved contact [...]

Published
2021
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18. Association of Shared Living Spaces and COVID-19 in University Students, Wisconsin, USA, 2020

Author

Bigouette, John Paul, Ford, Laura, Segaloff, Hannah E., Langolf, Kimberly, Kahrs, Juliana, Zochert, Tara, Tate, Jacqueline E., Gieryn, Douglas, Kirking, Hannah L., Westergaard, Ryan P., and Killerby, Marie E.

Subjects
Wisconsin -- Health aspects, Epidemics -- Statistics -- Risk factors -- United States, College students -- Statistics -- Health aspects -- Homes and haunts, Student housing -- Statistics -- Health aspects, Health
Abstract

In 2020, multiple outbreaks of coronavirus disease (COVID-19), the disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were documented in institutions of higher education (IHEs; e.g., [...]

Published
2021
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19. Interventions to Disrupt Coronavirus Disease Transmission at a University, Wisconsin, USA, August-October 2020

Author

Currie, Dustin W., Moreno, Gage K., Delahoy, Miranda J., Pray, Ian W., Jovaag, Amanda, Braun, Katarina M., Cole, Devlin, Shechter, Todd, Fajardo, Geroncio C., Griggs, Carol, Yandell, Brian S., Goldstein, Steve, Bushman, Dena, Segaloff, Hannah E., Kelly, G. Patrick, Pitts, Collin, Lee, Christine, Grande, Katarina M., Kita-Yarbro, Amanda, Grogan, Brittany, Mader, Sara, Baggott, Jake, Bateman, Allen C., Westergaard, Ryan P., Tate, Jacqueline E., Friedrich, Thomas C., Kirking, Hannah L., O'Connor, David H., and Killerby, Marie E.

Subjects
Wisconsin -- Health aspects, Epidemics -- Control -- Statistics -- United States, Public universities and colleges -- Safety and security measures -- Health aspects, Disease transmission -- Control, Health, University of Wisconsin -- Safety and security measures -- Health aspects
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), can spread rapidly within congregate settings, including institutions of higher education (IHEs) (1,2). During August-December 2020, as IHEs [...]

Published
2021
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21. Adolescent with COVID-19 as the Source of an Outbreak at a 3-Week Family Gathering — Four States, June–July 2020

Author

Schwartz, Noah G., Moorman, Anne C., Makaretz, Anna, Chang, Karen T., Chu, Victoria T., Szablewski, Christine M., Yousaf, Anna R., Brown, Marie M., Clyne, Ailis, DellaGrotta, Amanda, Drobeniuc, Jan, Korpics, Jacqueline, Muir, Adam, Drenzek, Cherie, Bandy, Utpala, Kirking, Hannah L., Tate, Jacqueline E., Hall, Aron J., Lanzieri, Tatiana M., and Stewart, Rebekah J.

Published
2020

22. Effects of Patient Characteristics on Diagnostic Performance of Self-Collected Samples for SARS-CoV-2 Testing

Author

Smith-Jeffcoat, Sarah E., Koh, Mitsuki, Hoffman, Adam, Rebolledo, Paulina A., Schechter, Marcos C., Miller, Halie K., Sleweon, Sadia, Rossetti, Rebecca, Kasinathan, Vyjayanti, Shragai, Talya, O'Laughlin, Kevin, Espinosa, Catherine C., Khalil, George M., Adeyemo, AdeSubomi O., Moorman, Anne, Bauman, Brenda L., Joseph, Kahaliah, O'Hegarty, Michelle, Kamal, Nazia, Atallah, Hany, Moore, Brooks L., Bohannon, Caitlin D., Bankamp, Bettina, Hartloge, Claire, Bowen, Michael D., Paulick, Ashley, Gargis, Amy S., Elkins, Christopher, Stewart, Rebekah J., da Silva, Juliana, Biedron, Caitlin, Tate, Jacqueline E., Wang, Yun F., and Kirking, Hannah L.

Subjects
Self-examination, Medical -- Methods, Medical testing products -- Usage, Health
Abstract

Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), originally relied mainly on nasopharyngeal swab (NPS) samples collected by healthcare workers (HCWs). However, [...]

Published
2021
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24. SARS-CoV-2 Transmission and Infection Among Attendees of an Overnight Camp — Georgia, June 2020

Author

Szablewski, Christine M., Chang, Karen T., Brown, Marie M., Chu, Victoria T., Yousaf, Anna R., Anyalechi, Ndubuisi, Aryee, Peter A., Kirking, Hannah L., Lumsden, Maranda, Mayweather, Erin, McDaniel, Clinton J., Montierth, Robert, Mohammed, Asfia, Schwartz, Noah G., Shah, Jaina A., Tate, Jacqueline E., Dirlikov, Emilio, Drenzek, Cherie, Lanzieri, Tatiana M., and Stewart, Rebekah J.

Published
2020

27. Persons Evaluated for 2019 Novel Coronavirus — United States, January 2020

Author

2019-nCoV Persons Under Investigation Team, Bajema, Kristina L., Oster, Alexandra M., McGovern, Olivia L., Lindstrom, Stephen, Stenger, Mark R., Anderson, Tara C., Isenhour, Cheryl, Clarke, Kevin R., Evans, Mary E., Chu, Victoria T., Biggs, Holly M., Kirking, Hannah L., Gerber, Susan I., Hall, Aron J., Fry, Alicia M., and Oliver, Sara E.

Published
2020

29. Characteristics and Timing of Initial Virus Shedding in Severe Acute Respiratory Syndrome Coronavirus 2, Utah, USA

Author

Lewis, Nathaniel M., Duca, Lindsey M., Marcenac, Perrine, Dietrich, Elizabeth A., Gregory, Christopher J., Fields, Victoria L., Banks, Michelle M., Rispens, Jared R., Hall, Aron, Harcourt, Jennifer L., Tamin, Azaibi, Willardson, Sarah, Kiphibane, Tair, Christensen, Kimberly, Dunn, Angela C., Tate, Jacqueline E., Nabity, Scott, Matanock, Almea M., and Kirking, Hannah L.

Subjects
Utah -- Health aspects, Virulence (Microbiology) -- Observations, Sentinel health events -- Methods, Company distribution practices, Health
Abstract

The coronavirus disease (COVID-19) outbreak first recognized in Wuhan, China, in December 2019 is now a global pandemic (1). Serial intervals for transmission have been estimated (2,3), and presymptomatic transmission [...]

Published
2021
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31. Symptoms, Viral Loads, and Rebound Among COVID-19 Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score–Matched Untreated Individuals.

Author

Smith-Jeffcoat, Sarah E, Biddle, Jessica E, Talbot, H Keipp, Morrissey, Kerry Grace, Stockwell, Melissa S, Maldonado, Yvonne, McLean, Huong Q, Ellingson, Katherine D, Bowman, Natalie M, Asturias, Edwin, Mellis, Alexandra M, Johnson, Sheroi, Kirking, Hannah L, Rolfes, Melissa A R, Olivo, Vanessa, Merrill, Lori, Battan-Wraith, Steph, Sano, Ellen, McLaren, Son H, and Vargas, Celibell Y

Subjects
VIRAL load, RESEARCH funding, POLYMERASE chain reaction, TREATMENT effectiveness, QUANTITATIVE research, ANTIVIRAL agents, OUTPATIENTS, RITONAVIR, COVID-19
Abstract

Background Nirmatrelvir/ritonavir (N/R) reduces severe outcomes from coronavirus disease 2019 (COVID-19); however, rebound after treatment has been reported. We compared symptom and viral dynamics in individuals with COVID-19 who completed N/R treatment and similar untreated individuals. Methods We identified symptomatic participants who tested severe acute respiratory syndrome coronavirus 2–positive and were N/R eligible from a COVID-19 household transmission study. Index cases from ambulatory settings and their households contacts were enrolled. We collected daily symptoms, medication use, and respiratory specimens for quantitative polymerase chain reaction for 10 days during March 2022—May 2023. Participants who completed N/R treatment (treated) were propensity score matched to untreated participants. We compared symptom rebound, viral load (VL) rebound, average daily symptoms, and average daily VL by treatment status measured after N/R treatment completion or 7 days after symptom onset if untreated. Results Treated (n = 130) and untreated participants (n = 241) had similar baseline characteristics. After treatment completion, treated participants had greater occurrence of symptom rebound (32% vs 20%; P =.009) and VL rebound (27% vs 7%; P <.001). Average daily symptoms were lower among treated participants without symptom rebound (1.0 vs 1.6; P <.01) but not statistically lower with symptom rebound (3.0 vs 3.4; P =.5). Treated participants had lower average daily VLs without VL rebound (0.9 vs 2.6; P <.01) but not statistically lower with VL rebound (4.8 vs 5.1; P =.7). Conclusions Individuals who completed N/R treatment experienced fewer symptoms and lower VL but rebound occured more often compared with untreated individuals. Providers should prescribe N/R, when indicated, and communicate rebound risk to patients. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Detection of a Human Adenovirus Outbreak, Including Some Critical Infections, Using Multipathogen Testing at a Large University, September 2022–January 2023.

Author

Montgomery, JoLynn P, Marquez, Juan Luis, Nord, Jennifer, Stamper, Aleksandra R, Edwards, Elizabeth A, Valentini, Nicholas, Frank, Christopher J, Washer, Laraine L, Ernst, Robert D, Park, Ji In, Price, Deanna, Collins, Jim, Smith-Jeffcoat, Sarah E, Hu, Fang, Knox, Christine L, Khan, Rebia, Lu, Xiaoyan, Kirking, Hannah L, and Hsu, Christopher H

Subjects
ADENOVIRUS diseases, STUDENT health services, ADENOVIRUSES, ELECTRONIC health records, EMERGENCY medical services, HUMAN adenoviruses
Abstract

Background Human adenoviruses (HAdVs) can cause outbreaks of flu-like illness in university settings. Most infections in healthy young adults are mild; severe illnesses rarely occur. In Fall 2022, an adenovirus outbreak was identified in university students. Methods HAdV cases were defined as university students 17–26 years old who presented to the University Health Service or nearby emergency department with flu-like symptoms (eg, fever, cough, headache, myalgia, nausea) and had confirmed adenovirus infections by polymerase chain reaction (PCR). Demographic and clinical characteristics were abstracted from electronic medical records; clinical severity was categorized as mild, moderate, severe, or critical. We performed contact investigations among critical cases. A subset of specimens was sequenced to confirm the HAdV type. Results From 28 September 2022 to 30 January 2023, 90 PCR-confirmed cases were identified (51% female; mean age, 19.6 years). Most cases (88.9%) had mild illness. Seven cases required hospitalization, including 2 critical cases that required intensive care. Contact investigation identified 44 close contacts; 6 (14%) were confirmed HAdV cases and 8 (18%) reported symptoms but never sought care. All typed HAdV-positive specimens (n = 36) were type 4. Conclusions While most students with confirmed HAdV had mild illness, 7 otherwise healthy students had severe or critical illness. Between the relatively high number of hospitalizations and proportion of close contacts with symptoms who did not seek care, the true number of HAdV cases was likely higher. Our findings illustrate the need to consider a wide range of pathogens, even when other viruses are known to be circulating. [ABSTRACT FROM AUTHOR]

Published
2024
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35. 2652. Detection of respiratory viruses by air sampling and student and staff surveillance testing in two elementary schools

Author

Gard, Luke C, primary, Goldman, Jennifer, additional, Selvarangan, Rangaraj, additional, Sasidharan, Anjana, additional, Banerjee, Dithi, additional, Hayes, Amanda M, additional, Petty, Sydnie, additional, Almendares, Olivia, additional, Sleweon, Sadia, additional, Kirking, Hannah L, additional, and Schuster, Jennifer E, additional

Published
2023
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36. 930. COVID-19 symptom and viral load rebound among individuals reporting nirmatrelvir/ritonavir use compared to propensity score matched individuals not taking COVID-19 treatment

Author

Smith-Jeffcoat, Sarah E, primary, Biddle, Jessica E, additional, Talbot, H Keipp, additional, Olivo, Vanessa, additional, Sano, Ellen, additional, Goodman, Sara H, additional, Petrie, Joshua, additional, Ledezma, Karla I, additional, Bullock, Ayla, additional, Rao, Suchitra, additional, Mellis, Alexandra, additional, Johnson, Sheroi, additional, Kirking, Hannah L, additional, Rolfes, Melissa A, additional, Zhu, Yuwei, additional, Schmitz, Jonathan, additional, Hart, Kimberly W, additional, Battan-Wraith, Steph, additional, Merrill, Lori S, additional, McLaren, Son H, additional, Vargas, Celibell, additional, Sarnquist, Clea, additional, Govindaranjan, Prasanthi, additional, Belongia, Edward, additional, Pryor, Kathleen, additional, Lutrick, Karen, additional, Yang, Amy, additional, Haehnel, Quenla, additional, Asturias, Edwin J, additional, Bowman, Natalie M, additional, Ellingson, Katherine, additional, McLean, Huong, additional, Maldonado, Yvonne A, additional, Stockwell, Melissa, additional, Morrissey, Kerry Grace, additional, Grijalva, Carlos G, additional, and Salvatore, Phillip P, additional

Published
2023
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37. Symptoms, Viral Loads, and Rebound Among COVID-19 Outpatients Treated With Nirmatrelvir/Ritonavir Compared With Propensity Score–Matched Untreated Individuals

Author

Smith-Jeffcoat, Sarah E, primary, Biddle, Jessica E, additional, Talbot, H Keipp, additional, Morrissey, Kerry Grace, additional, Stockwell, Melissa S, additional, Maldonado, Yvonne, additional, McLean, Huong Q, additional, Ellingson, Katherine D, additional, Bowman, Natalie M, additional, Asturias, Edwin, additional, Mellis, Alexandra M, additional, Johnson, Sheroi, additional, Kirking, Hannah L, additional, Rolfes, Melissa A R, additional, Olivo, Vanessa, additional, Merrill, Lori, additional, Battan-Wraith, Steph, additional, Sano, Ellen, additional, McLaren, Son H, additional, Vargas, Celibell Y, additional, Goodman, Sara, additional, Sarnquist, Clea C, additional, Govindaranjan, Prasanthi, additional, Petrie, Joshua G, additional, Belongia, Edward A, additional, Ledezma, Karla, additional, Pryor, Kathleen, additional, Lutrick, Karen, additional, Bullock, Ayla, additional, Yang, Amy, additional, Haehnel, Quenla, additional, Rao, Suchitra, additional, Zhu, Yuwei, additional, Schmitz, Jonathan, additional, Hart, Kimberly, additional, Grijalva, Carlos G, additional, and Salvatore, Phillip P, additional

Published
2023
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39. Paediatric acute hepatitis of unknown aetiology: a national surveillance investigation in the USA during 2021 and 2022

Author

Cates, Jordan, primary, Baker, Julia M, additional, Almendares, Olivia, additional, Balachandran, Neha, additional, McKeever, Erin R, additional, Kambhampati, Anita K, additional, Cubenas, Caelin, additional, Vinjé, Jan, additional, Cannon, Jennifer L, additional, Chhabra, Preeti, additional, Freeman, Brandi, additional, Reagan-Steiner, Sarah, additional, Bhatnagar, Julu, additional, Gastañaduy, Paul A, additional, Kirking, Hannah L, additional, Sugerman, David, additional, Parashar, Umesh D, additional, Tate, Jacqueline E, additional, Burke, Rachel M., additional, Burnett, Eleanor, additional, Vega, Everardo M., additional, Lu, Xiaoyan, additional, Coughlin, Melissa M., additional, Bankamp, Bettina, additional, Leitgeb, Brooke, additional, Estetter, Lindsey Blythe Coulter, additional, Silva-Flannery, Lucinia, additional, Martines, Roosecelis B., additional, Wadford, Debra A., additional, Morales, Christina, additional, Pan, Chao-Yang, additional, Popowich, Michael, additional, Lamson, Daryl M., additional, St. George, Kirsten, additional, Cebelinski, Elizabeth, additional, Panek, Anna, additional, Ingram, L. Amanda, additional, Ayers-Millsap, Stephanie, additional, Dulski, Theresa, additional, Reed, Tameika, additional, Sietsema, Lydia, additional, Savella, Adrian, additional, Derby, Mary P., additional, Matthews, James, additional, Abe, Kentaro F., additional, Rizzo, Kyle R., additional, Stockman, Lauren J., additional, Dao, Bonnie L., additional, Burakoff, Alexis, additional, Tapay, Diana, additional, Kacka, Michael, additional, Gacek, Paul, additional, Phan, Quyen, additional, Langer, Christina, additional, Kupferman, Nikki, additional, Gent, Ashley, additional, Dessi, Dalton, additional, Tobin-D'Angelo, Melissa, additional, Gandhi, Ami, additional, Carter, Kris K., additional, Leslie, Matthew T., additional, Saathoff-Huber, Lori, additional, Stone, Nicole, additional, Hodge, Bethany, additional, Odegard, Amanda, additional, Hand, Julia, additional, Jacoboski, Juliana, additional, Nguyen, Christine, additional, Manchester, Chloe, additional, Smith, Emer, additional, Ladisky, Macey, additional, Brousseau, Geoff, additional, Grilli, Genny, additional, Freitas, Mari, additional, Berkley, Alexandra, additional, Do, Michael, additional, Hanson, Jennifer, additional, Boutwell, Carla, additional, VanderBusch, Lindsey, additional, Renton, Shari, additional, Goebel, Rachel, additional, Sato, Alice I., additional, Donahue, Matthew, additional, Julian, Derek, additional, Mallory, Krystle, additional, Bridges, Deanna, additional, Thomas, Deepam, additional, Stadelman, Anna M, additional, Gehre, Mika, additional, Holzinger, Nora, additional, Peek-Bullock, Melissa, additional, Sepcic, Victoria, additional, Ghadge, Nitin M, additional, Byun, Youjung, additional, Anderson, Bridget J., additional, Balan, Dominique, additional, Antwi, Mike, additional, Taylor, Brandi, additional, Dewart, Courtney, additional, Wayman, Ashlyn, additional, Solberg, Marie, additional, Lund, Hannah, additional, Plipat, Nottasorn, additional, Wallace, Jennifer L., additional, Cardona, Iris, additional, Rodríguez, Melissa Marzán, additional, Berns, Abby L., additional, McAuley, Patricia, additional, Campbell, Chelsea, additional, Clayton, Joshua, additional, Schultz, Jessica, additional, Wallace, Ryan, additional, Salmanson, Amelia Prebish, additional, Saady, Dawn, additional, Heaton, Tabatha, additional, Carlson, Kimberly, additional, Dodd, Amanda, additional, Haupt, Thomas, additional, McLemore, Stephanie D., additional, and del Rosario, Maria C., additional

Published
2023
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40. Increase in Acute Respiratory Illnesses Among Children and Adolescents Associated with Rhinoviruses and Enteroviruses, Including Enterovirus D68-United States, July-September 2022

Author

Ma, Kevin C., Winn, Amber, Moline, Heidi L., Scobie, Heather M., Midgley, Claire M., Kirking, Hannah L., Adjemian, Jennifer, Hartnett, Kathleen P., Johns, Dylan, Jones, Jefferson M., Lopez, Adriana, Lu, Xiaoyan, Perez, Ariana, Perrine, Cria G., Rzucidlo, Andzelika E., McMorrow, Meredith L., Silk, Benjamin J., Stein, Zachary, Vega, Everardo, and Hall, Aron J.

Subjects
Children -- Diseases, Respiratory tract diseases, Health
Abstract

On September 27, 2022, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). Increases in severe respiratory illness and acute flaccid myelitis (AFM) among children [...]

Published
2022

41. Epidemiology of SARS-CoV-2 transmission and superspreading in Salt Lake County, Utah, March–May 2020

Author

Walker, Joseph, primary, Tran, Tiffany, additional, Lappe, Brooke, additional, Gastanaduy, Paul, additional, Paul, Prabasaj, additional, Kracalik, Ian T., additional, Fields, Victoria L., additional, Lopez, Adriana, additional, Schwartz, Amy, additional, Lewis, Nathaniel M., additional, Tate, Jacqueline E., additional, Kirking, Hannah L., additional, Hall, Aron J., additional, Pevzner, Eric, additional, Khong, Ha, additional, Smithee, Maureen, additional, Lowry, Jason, additional, Dunn, Angela, additional, Kiphibane, Tair, additional, and Tran, Cuc H., additional

Published
2023
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42. Evaluation of Correctional Facility COVID-19 Outbreaks With Layered Mitigation Strategies Including Vaccination: Colorado, 2020–2021

Author

Martinez, Heather E., primary, Marshall, Kristen E., additional, Showell, Velton W., additional, Tate, Jacqueline E., additional, Kirking, Hannah L., additional, Broudy, Melissa, additional, Matzinger, Shannon R., additional, Burakoff, Alexis, additional, Deng, Li, additional, Payne, Daniel C., additional, Fleming-Dutra, Katherine, additional, and Jervis, Rachel H., additional

Published
2023
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43. Interim Analysis of Acute Hepatitis of Unknown Etiology in Children Aged <10 Years--United States, October 2021-June 2022

Author

Cates, Jordan, Baker, Julia M., Almendares, Olivia, Kambhampati, Anita K., Burke, Rachel M., Balachandran, Neha, Burnett, Eleanor, Potts, Caelin C., Reagan-Steiner, Sarah, Kirking, Hannah L., Sugerman, David, Parashar, Umesh D., and Tate, Jacqueline E.

Subjects
North Carolina. Department of Health and Human Services -- Analysis, United States. Epidemic Intelligence Service -- Analysis, Children's furniture -- Analysis, Hepatitis -- Development and progression, Public health -- Analysis, Diseases -- Causes and theories of causation, Adenoviruses -- Analysis, Health
Abstract

On June 24, 2022, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). On April 21, 2022, CDC issued a health advisory ([dagger]) encouraging U.S. [...]

Published
2022

44. Trends in Acute Hepatitis of Unspecified Etiology and Adenovirus Stool Testing Results in Children--United States, 2017-2022

Author

Kambhampati, Anita K., Burke, Rachel M., Dietz, Stephanie, Sheppard, Michael, Almendares, Olivia, Baker, Julia M., Cates, Jordan, Stein, Zachary, Johns, Dylan, Smith, Amanda R., Bull-Otterson, Lara, Hofmeister, Megan G., Cobb, Stacy, Dale, Suzanne E., Soetebier, Karl A., Potts, Caelin C., Adjemian, Jennifer, Kite-Powell, Aaron, Hartnett, Kathleen P., Kirking, Hannah L., Sugerman, David, Parashar, Umesh D., and Tate, Jacqueline E.

Subjects
Hepatitis, Pediatrics, Public health, Diseases -- Causes and theories of causation, Adenoviruses, Health
Abstract

On June 14, 2022, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). In November 2021, CDC was notified of a cluster of previously healthy [...]

Published
2022

45. SARS-CoV-2 viral shedding in vaccinated and unvaccinated persons: A case series

Author

McCormick, David W., primary, Hagan, Liesl M., additional, Salvatore, Phillip P., additional, Magleby, Reed, additional, Lee, Christine, additional, Sleweon, Sadia, additional, Nicolae, Lavinia, additional, Dixon, Tom, additional, Banta, Robert, additional, Ogle, Isaac, additional, Young, Cristen, additional, Dusseau, Charles, additional, Ogden, Charles, additional, Browne, Hannah, additional, Michael Metz, John, additional, Chen, Min-hsin, additional, Solano, Maria I., additional, Rogers, Shannon, additional, Burgin, Alex, additional, Sheth, Mili, additional, Bankamp, Bettina, additional, Tamin, Azaibi, additional, Harcourt, Jennifer L., additional, Tate, Jacqueline E., additional, and Kirking, Hannah L., additional

Published
2023
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46. Modelling the impact of CD4 testing on mortality from TB and cryptococcal meningitis among patients with advanced HIV disease in nine countries

Author

Oboho, Ikwo Kitefre, primary, Paulin, Heather, additional, Corcoran, Carl, additional, Hamilton, Matt, additional, Jordan, Alex, additional, Kirking, Hannah L., additional, Agyemang, Elfriede, additional, Podewils, Laura Jean, additional, Pretorius, Carel, additional, Greene, Greg, additional, Chiller, Tom, additional, Desai, Mitesh, additional, Bhatkoti, Roma, additional, Shiraishi, Ray W., additional, and Shah, N. Sarita, additional

Published
2023
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47. SARS-CoV-2 B.1.1.529 (Omicron) Variant Transmission Within Households--Four U.S. Jurisdictions, November 2021-February 2022

Author

Baker, Julia M., Nakayama, Jasmine Y., O'Hegarty, Michelle, McGowan, Andrea, Teran, Richard A., Bart, Stephen M., Mosack, Katie, Roberts, Nicole, Campos, Brooke, Paegle, Alina, McGee, John, Herrera, Robert, English, Kayla, Barrios, Carla, Davis, Alexandria, Roloff, Christine, Sosa, Lynn E., Brockmeyer, Jessica, Page, Lindsey, Bauer, Amy, Weiner, Joshua J., Khubbar, Manjeet, Bhattacharyya, Sanjib, Kirking, Hannah L., and Tate, Jacqueline E.

Subjects
Jurisdiction -- Health aspects, Infection -- Prevention, Disease transmission -- Prevention, Health
Abstract

On February 25, 2022, this report was posted as an MMWR Early Release on the MMWR website (https:llwww.cdc.gov/mmwr). The B.1.1.529 (Omicron) variant, first detected in November 2021, was responsible for [...]

Published
2022

48. Pediatric Emergency Department Visits Associated with Mental Health Conditions Before and During the COVID-19 Pandemic--United States, January 2019-January 2022

Author

Radhakrishnan, Lakshmi, Leeb, Rebecca T., Bitsko, Rebecca H., Carey, Kelly, Gates, Abigail, Holland, Kristin M., Hartnett, Kathleen P., Kite-Powell, Aaron, DeVies, Jourdan, Smith, Amanda R., van Santen, Katharina L., Crossen, Sophia, Sheppard, Michael, Wotiz, Samantha, Lane, Rashon I., Njai, Rashid, Johnson, Amelia G., Winn, Amber, Kirking, Hannah L., Rodgers, Loren, Thomas, Craig W., Soetebier, Karl, Adjemian, Jennifer, and Anderson, Kayla N.

Subjects
Hospitals -- Emergency service, Mental health -- Reports, Pediatric emergencies -- Reports, Health
Abstract

On February 18, 2022, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). In 2021, a national emergency* for children's mental health was declared by [...]

Published
2022

49. Pediatric Emergency Department Visits Before and During the COVID-19 Pandemic--United States, January 2019-January 2022

Author

Radhakrishnan, Lakshmi, Carey, Kelly, Hartnett, Kathleen P., Kite-Powell, Aaron, Zwald, Marissa, Anderson, Kayla N., Leeb, Rebecca T., Holland, Kristin M., Gates, Abigail, DeVies, Jourdan, Smith, Amanda R., van Santen, Katharina L., Crossen, Sophia, Sheppard, Michael, Wotiz, Samantha, Johnson, Amelia G., Winn, Amber, Kirking, Hannah L., Lane, Rashon I., Njai, Rashid, Rodgers, Loren, Thomas, Craig W., Soetebier, Karl, and Adjemian, Jennifer

Subjects
Hospitals -- Emergency service, Pediatric emergencies, Children -- Health aspects, Health
Abstract

On February 18, 2022, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). Emergency departments (EDs) in the United States remain a frontline resource for [...]

Published
2022

50. Antigen Test Positivity After COVID-19 Isolation--Yukon-Kuskokwim Delta Region, Alaska, January-February 2022

Author

Lefferts, Brian, Blake, Ian, Bruden, Dana, Hagen, Melissa B., Hodges, Ellen, Kirking, Hannah L., Bates, Elizabeth, Hoeldt, Amanda, Lamont, Brenda, Saydah, Sharon, MacNeil, Adam, Bruce, Michael G., and Plumb, Ian D.

Subjects
Antigens -- Health aspects, Infection -- Health aspects, Health
Abstract

Isolation is recommended during acute infection with SARS-CoV-2, the virus that causes COVID-19, but the duration of infectiousness varies among individual persons. Rapid antigen test results have been correlated with [...]

Published
2022

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