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Unlabelled: Stress-damage of upper gastro-intestinal tract (GIT) mucous membrane and gastro-intestinal hemorrhage (GIH) increase the lethality of patients in the departments of reanimation and intensive care unit. The purpose of this study is to evaluate effectiveness and safety of pantoprazole use in patients with at least one risk factor of upper GIT mucosa stresses-damage and GIH. An important part of this study was examination of 24-hour intragastric pH - control results in patients during 1-st day after the surgery., Materials and Methods: Pantoprazole antisecretory therapy conducted in 40 patients, 38 of which had at least one risk factor of upper GIT mucosa stresses-damage and GIH. If there are risk factors, in the postoperative period prescribed pantoprazole (controlok) 80 mg/day bolus intravenously, then went to 40 mg/day per os. The criteria of the preventive therapy efficiency were absence of manifest and/or clinically significant GIH symptoms, the need for emergency upper endoscopy and emergency surgery, caused by the GIH. Among the patients with risk factors were marked out 15 patients: liver cirrhosis, portal hypertension syndrome (esophagus and stomach varix), liver failure (Child-Pugh A/B), high risk of hemorrhage. Within 24 hours, a constant intragastric-Ph monitoring ws carried out., Results: During observation in all patients, which were undergoing upper GIT mucosa stress-damage prevention, there was no need for emergency upper endoscopy. No patients needed to carry out emergency surgery, caused by the GIH. Lethality rate in this group was absent., Conclusions: The use of pantoprazole demonstrates its good efficiency and tolerance.

The amount of non-cardiosurgical interventions rises every year approximately by 1.5%. The main growth is due to the enlargement of old and elderly patients group. This group has the highest evidence of cardiovascular diseases. The frequency of sudden cardiac death and myocardial infarction after non-cardiosurgical interventions is approximately 3.5%. The prevalence of arrhythmias in postoperative period reaches 20%. The issue of postoperative arrhythmias is a very actual problem of intensive care which needs further research. Preoperative arrhythmias are an independent risk factor of cardiological postoperative complications. The treatment by beta blockers and antiarrhythmics can lead to a resistant bradycardia. Different cardio stimulators are being used for the means of prophylaxis and treatment.