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2. Direct Transmission of Severe Fever with Thrombocytopenia Syndrome Virus from Domestic Cat to Veterinary Personnel

Author

Yamanaka, Atsushi, Kirino, Yumi, Fujimoto, Sho, Ueda, Naoyasu, Himeji, Daisuke, Miura, Miho, Sudaryatma, Putu E., Sato, Yukiko, Tanaka, Hidenori, Mekata, Hirohisa, and Okabayashi, Tamaki

Subjects
Tick-borne diseases -- Causes of -- Diagnosis, Epidemics -- Causes of -- Japan, Cats -- Health aspects, Animal health technicians -- Health aspects, Zoonoses -- Causes of -- Diagnosis, Disease transmission -- Causes of, RNA virus infections -- Causes of -- Diagnosis, Health
Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is caused by the species Dabie bandavirus (family Phenuiviridae, genus Bandavirus), generally called severe fever with thrombocytopenia syndrome virus (SFTSV) (1,2). Cases of SFTS [...]

Published
2020
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6. Serological and molecular survey of tick‐borne zoonotic pathogens including severe fever with thrombocytopenia syndrome virus in wild boars in Miyazaki Prefecture, Japan

Author

Kirino, Yumi, primary, Yamamoto, Seigo, additional, Nomachi, Taro, additional, Mai, Thi Ngan, additional, Sato, Yukiko, additional, Sudaryatma, Putu Eka, additional, Norimine, Junzo, additional, Fujii, Yoshinori, additional, Ando, Shuji, additional, and Okabayashi, Tamaki, additional

Published
2021
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9. Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus in Small-Animal Veterinarians and Nurses in the Japanese Prefecture with the Highest Case Load

Author

Kirino, Yumi, primary, Ishijima, Keita, additional, Miura, Miho, additional, Nomachi, Taro, additional, Mazimpaka, Eugene, additional, Sudaryatma, Putu Eka, additional, Yamanaka, Atsushi, additional, Maeda, Ken, additional, Sugimoto, Takayuki, additional, Saito, Akatsuki, additional, Mekata, Hirohisa, additional, and Okabayashi, Tamaki, additional

Published
2021
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13. Serological and molecular survey of tick‐borne zoonotic pathogens including severe fever with thrombocytopenia syndrome virus in wild boars in Miyazaki Prefecture, Japan.

Author

Kirino, Yumi, Yamamoto, Seigo, Nomachi, Taro, Mai, Thi Ngan, Sato, Yukiko, Sudaryatma, Putu Eka, Norimine, Junzo, Fujii, Yoshinori, Ando, Shuji, and Okabayashi, Tamaki

Subjects
*WILD boar, *TSUTSUGAMUSHI disease, *TICK-borne diseases, *THROMBOCYTOPENIA, *VIRAL genes
Abstract

Background: Miyazaki Prefecture is one of the hotspots of severe fever with thrombocytopenia syndrome (SFTS) cases and related deaths in Japan since 2013 and other pathogens of tick‐borne diseases (TBDs). Japanese spotted fever and scrub typhus are also endemic in this region. Objectives: A total of 105 wild boars, hunted in 2009, were serologically examined as sentinels for TBDs to indirectly demonstrate the potential hazard of ticks transmitting pathogens to humans in the studied area. Methods: The collected blood and spleens of the wild boars underwent serological and molecular tests for SFTSV, Rickettsia japonica (Rj) [antibody to spotted fever group rickettsiae (SFGR) were tested by using species‐common antigen], and Orientia tsutsugamushi (Ot). Results: Seroprevalences of SFTSV, SFGR, and Ot were 41.9%, 29.5%, and 33.3%, respectively. SFTS viral RNA was identified in 7.6% of the sera, whereas DNA of Rj or Ot was not detected in any sample. In total, 43.8% of the boars possessed an infection history with SFTSV (viral gene and/or antibody). Of these, 23.8% had multiple‐infection history with SFGR and/or Ot. Conclusions: The high prevalence of SFTSV in wild boars might reflect the high risk of exposure to the virus in the studied areas. In addition, SFTSV infection was significantly correlated with Ot infection, and so were SFGR infection and Ot infection, indicating that these pathogens have common factors for infection or transmission. These data caution of the higher risk of SFTSV infection in areas with reported cases of other TBDs. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads

Author

HAYASHI, Takumi, MEKATA, Hirohisa, SEKIGUCHI, Satoshi, KIRINO, Yumi, MITOMA, Shuya, HONKAWA, Kazuyuki, HORII, Yoichiro, and NORIMINE, Junzo

Subjects
animal diseases, viruses, proviral load, BLV, DRB3*0902, Histocompatibility Antigens Class II, Enzootic Bovine Leukosis, Viral Load, Note, polymorphism, Proviruses, Virology, BoLA class II, Leukemia Virus, Bovine, Animals, Cattle, Alleles, Disease Resistance
Abstract

The bovine MHC (BoLA) class II DRB3 alleles are associated with polyclonal expansion of lymphocytes caused by bovine leukemia virus (BLV) infection in cattle. To examine whether the DRB3*0902 allele, one of the resistance-associated alleles, is associated with the proviral load, we measured BLV proviral load of BLV-infected cattle and clarified their DRB3 alleles. Fifty-seven animals with DRB3*0902 were identified out of 835 BLV-infected cattle and had significantly lower proviral load (P

Published
2017

16. Large-scale genome analysis of bovine commensal Escherichia coli reveals that bovine-adapted E. coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains

Author

Arimizu, Yoko, primary, Kirino, Yumi, additional, Sato, Mitsuhiko P., additional, Uno, Koichi, additional, Sato, Toshio, additional, Gotoh, Yasuhiro, additional, Auvray, Frédéric, additional, Brugere, Hubert, additional, Oswald, Eric, additional, Mainil, Jacques G., additional, Anklam, Kelly S., additional, Döpfer, Dörte, additional, Yoshino, Shuji, additional, Ooka, Tadasuke, additional, Tanizawa, Yasuhiro, additional, Nakamura, Yasukazu, additional, Iguchi, Atsushi, additional, Morita-Ishihara, Tomoko, additional, Ohnishi, Makoto, additional, Akashi, Koichi, additional, Hayashi, Tetsuya, additional, and Ogura, Yoshitoshi, additional

Published
2019
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17. A Risk Assessment of Aflatoxin M1 Exposure in Low and Mid-Income Dairy Consumers in Kenya

Author

Ahlberg, Sara, Grace, Delia, Kiarie, Gideon, Kirino, Yumi, Lindahl, Johanna, Ahlberg, Sara, Grace, Delia, Kiarie, Gideon, Kirino, Yumi, and Lindahl, Johanna

Abstract

Aflatoxin M-1 (AFM(1)), a human carcinogen, is found in milk products and may have potentially severe health impacts on milk consumers. We assessed the risk of cancer and stunting as a result of AFM(1) consumption in Nairobi, Kenya, using worst case assumptions of toxicity and data from previous studies. Almost all (99.5%) milk was contaminated with AFM(1). Cancer risk caused by AFM(1) was lower among consumers purchasing from formal markets (0.003 cases per 100,000) than for low-income consumers (0.006 cases per 100,000) purchasing from informal markets. Overall cancer risk (0.004 cases per 100,000) from AFM(1) alone was low. Stunting is multifactorial, but assuming only AFM(1) consumption was the determinant, consumption of milk contaminated with AFM(1) levels found in this study could contribute to 2.1% of children below three years in middle-income families, and 2.4% in low-income families, being stunted. Overall, 2.7% of children could hypothetically be stunted due to AFM(1) exposure from milk. Based on our results AFM(1) levels found in milk could contribute to an average of -0.340 height for age z-score reduction in growth. The exposure to AFM(1) from milk is 46 ng/day on average, but children bear higher exposure of 3.5 ng/kg bodyweight (bw)/day compared to adults, at 0.8 ng/kg bw/day. Our paper shows that concern over aflatoxins in milk in Nairobi is disproportionate if only risk of cancer is considered, but that the effect on stunting children might be much more significant from a public health perspective; however, there is still insufficient data on the health effects of AFM(1).

Published
2018
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18. Direct Transmission of Severe Fever with Thrombocytopenia Syndrome Virus from Domestic Cat to Veterinary Personnel.

Author

Atsushi Yamanaka, Yumi Kirino, Sho Fujimoto, Naoyasu Ueda, Daisuke Himeji, Miho Miura, Sudaryatma, Putu E., Yukiko Sato, Hidenori Tanaka, Hirohisa Mekata, Tamaki Okabayashi, Yamanaka, Atsushi, Kirino, Yumi, Fujimoto, Sho, Ueda, Naoyasu, Himeji, Daisuke, Miura, Miho, Sato, Yukiko, Tanaka, Hidenori, and Mekata, Hirohisa

Abstract

Two veterinary personnel in Japan were infected with severe fever with thrombocytopenia syndrome virus (SFTSV) while handling a sick cat. Whole-genome sequences of SFTSV isolated from the personnel and the cat were 100% identical. These results identified a nosocomial outbreak of SFTSV infection in an animal hospital without a tick as a vector. [ABSTRACT FROM AUTHOR]

Published
2020
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20. Dembo polymerase chain reaction technique for detection of bovine abortion, diarrhea, and respiratory disease complex infectious agents in potential vectors and reservoirs

Author

Rahpaya, Sayed Samim, primary, Tsuchiaka, Shinobu, additional, Kishimoto, Mai, additional, Oba, Mami, additional, Katayama, Yukie, additional, Nunomura, Yuka, additional, Kokawa, Saki, additional, Kimura, Takashi, additional, Kobayashi, Atsushi, additional, Kirino, Yumi, additional, Okabayashi, Tamaki, additional, Nonaka, Nariaki, additional, Mekata, Hirohisa, additional, Aoki, Hiroshi, additional, Shiokawa, Mai, additional, Umetsu, Moeko, additional, Morita, Tatsushi, additional, Hasebe, Ayako, additional, Otsu, Keiko, additional, Asai, Tetsuo, additional, Yamaguchi, Tomohiro, additional, Makino, Shinji, additional, Murata, Yoshiteru, additional, Abi, Ahmad Jan, additional, Omatsu, Tsutomu, additional, and Mizutani, Tetsuya, additional

Published
2018
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22. Population structure of Escherichia coli O26 : H11 with recent and repeated stx2 acquisition in multiple lineages

Author

Ogura, Yoshitoshi, primary, Gotoh, Yasuhiro, additional, Itoh, Takehiko, additional, Sato, Mitsuhiko P., additional, Seto, Kazuko, additional, Yoshino, Shyuji, additional, Isobe, Junko, additional, Etoh, Yoshiki, additional, Kurogi, Mariko, additional, Kimata, Keiko, additional, Maeda, Eriko, additional, Piérard, Denis, additional, Kusumoto, Masahiro, additional, Akiba, Masato, additional, Tominaga, Kiyoshi, additional, Kirino, Yumi, additional, Kato, Yuki, additional, Shirahige, Katsuhiko, additional, Ooka, Tadasuke, additional, Ishijima, Nozomi, additional, Lee, Ken-ichi, additional, Iyoda, Sunao, additional, Mainil, Jacques Georges, additional, and Hayashi, Tetsuya, additional

Published
2017
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23. Continuous Moniezia benedeni Infection in Confined Cattle Possibly Maintained by an Intermediate Host on the Farm

Author

IRIE, Takao, SAKAGUCHI, Kohei, OTA-TOMITA, Aino, TANIDA, Miwako, HIDAKA, Kanako, KIRINO, Yumi, NONAKA, Nariaki, and HORII, Yoichiro

Subjects
Oribatula sakamorii, Mites, Full Paper, treatment, Cattle Diseases, Moniezia benedeni, Cestode Infections, Housing, Animal, Praziquantel, Feces, Japan, Prevalence, Animals, Cestoda, Parasitology, confined cattle, epidemiology, Cattle, Seasons, Disease Reservoirs
Abstract

Infection with Moniezia benedeni is sometimes found in confined cattle in Japan. Between October 2011 and January 2013, we monitored the fecal egg prevalence at a confined cattle farm in Miyazaki prefecture where continuous M. benedeni infection has been recognized for years to evaluate the possible infection routes. Fecal egg prevalence changed seasonally with the highest in October 2011 (27.3%: 9/33). This was followed by a gradual decrease until July 2012 (9.4%: 3/32) and then an increase between August to December 2012 when new egg-excreting cases were observed. The pattern of seasonal changes was similar to that reported previously for cattle kept in a barn with an outside playing yard. Although M. benedeni-infected mites were not found, we constantly detected an oribatid mite, Oribatula sakamorii Aoki, 1970, in the litter of cattle bedding from May to October 2012. This species belongs to a genus which has been reported to be a suitable intermediate host for M. benedeni, suggesting that M. benedeni infection may have been autonomously maintained at the farm via oribatid mites living in the cowshed. When infected cattle were treated with praziquantel, it was found that a single oral inoculation with a dose of 5 mg/kg was effective for deworming.

Published
2013

27. Partial costectomy for tracheal collapse and stenosis associated with perinatal rib fracture in three Japanese Black calves

Author

HIDAKA, Yuichi, primary, HAGIO, Mitsuyoshi, additional, KASHIBA, Ichiro, additional, ANDO, Kei, additional, OTANI, Yuki, additional, SATOH, Hiroyuki, additional, KONISHI, Yuko, additional, TSUZUKI, Nao, additional, HOKAMURA, Junichi, additional, KAJISA, Makoto, additional, WADA, Mie, additional, KIRINO, Yumi, additional, and ASANUMA, Taketoshi, additional

Published
2016
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28. Large-scale genome analysis of bovine commensal Escherichia colireveals that bovine-adapted E. colilineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains

Author

Arimizu, Yoko, Kirino, Yumi, Sato, Mitsuhiko P., Uno, Koichi, Sato, Toshio, Gotoh, Yasuhiro, Auvray, Frédéric, Brugere, Hubert, Oswald, Eric, Mainil, Jacques G., Anklam, Kelly S., Do¨pfer, Do¨rte, Yoshino, Shuji, Ooka, Tadasuke, Tanizawa, Yasuhiro, Nakamura, Yasukazu, Iguchi, Atsushi, Morita-Ishihara, Tomoko, Ohnishi, Makoto, Akashi, Koichi, Hayashi, Tetsuya, and Ogura, Yoshitoshi

Abstract

How pathogens evolve their virulence to humans in nature is a scientific issue of great medical and biological importance. Shiga toxin (Stx)–producing Escherichia coli(STEC) and enteropathogenic E. coli(EPEC) are the major foodborne pathogens that can cause hemolytic uremic syndrome and infantile diarrhea, respectively. The locus of enterocyte effacement (LEE)–encoded type 3 secretion system (T3SS) is the major virulence determinant of EPEC and is also possessed by major STEC lineages. Cattle are thought to be the primary reservoir of STEC and EPEC. However, genome sequences of bovine commensal E. coliare limited, and the emerging process of STEC and EPEC is largely unknown. Here, we performed a large-scale genomic comparison of bovine commensal E. coliwith human commensal and clinical strains, including EPEC and STEC, at a global level. The analyses identified two distinct lineages, in which bovine and human commensal strains are enriched, respectively, and revealed that STEC and EPEC strains have emerged in multiple sublineages of the bovine-associated lineage. In addition to the bovine-associated lineage-specific genes, including fimbriae, capsule, and nutrition utilization genes, specific virulence gene communities have been accumulated in stx-and LEE-positive strains, respectively, with notable overlaps of community members. Functional associations of these genes probably confer benefits to these E. colistrains in inhabiting and/or adapting to the bovine intestinal environment and drive their evolution to highly virulent human pathogens under the bovine-adapted genetic background. Our data highlight the importance of large-scale genome sequencing of animal strains in the studies of zoonotic pathogens.

Published
2019
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37. Identification of O Serotypes, Genotypes, and Virulotypes of Shiga Toxin-Producing Escherichia coliIsolates, Including Non-O157 from Beef Cattle in Japan

Author

Mekata, Hirohisa, Iguchi, Atsushi, Kawano, Kimiko, Kirino, Yumi, Kobayashi, Ikuo, and Misawa, Naoaki

Abstract

Bovines are recognized as an important reservoir of Shiga toxin-producing Escherichia coli(STEC). Although STEC strains are significant foodborne pathogens, not all of the STEC held by cattle are pathogenic, and which type of STEC that will become epidemic in humans is unpredictable. Information about the prevalence of serotype and virulence gene distribution in beef cattle is insufficient to develop monitoring and controlling activities for a food safety and security program. Thus, this study investigated the prevalence of O157 and non-O157 STEC in Japanese beef cattle and characterized the isolates by the type of O antigen and several virulence markers to help predict the pathogenicity. In this study, 64.2% (176 of 274) of enrichment cultures of fecal samples collected from an abattoir and farms were stx1and/or stx2positive by PCR. STEC strains were isolated from 22.1% (39 of 176) of the positive fecal samples, and these isolates represented 17 types of O antigen (O1, O2 or O50, O5, O8, O55, O84, O91, O109, O113, O136, O150, O156, O157, O163, O168, O174, and O177). Two selective media targeting major STEC groups, cefixime-tellurite sorbitol MacConkey agar and CHROMagar O26/O157, allowed isolation of a variety of STEC strains. The most frequently isolated STEC was O113 (8 of 39), which has previously been reported as a cause of foodborne infections. Although most of the O113 STEC isolated from infected patients possessed the enterohemolysin (hlyA) gene, none of the O113 STEC cattle isolates possessed the hlyAgene. The second most common isolate was O157 (6 of 39), and all these isolates contained common virulence factors, including eae, tir, lpf1, lpf2, and hlyA.This study shows the prevalence of O157 and non-O157 STEC in Japanese beef cattle and the relationship of O antigen and virulotypes of the isolates. This information may improve identification of the source of infection, developing surveillance programs or the current understanding of virulence factors of STEC infections.

Published
2014
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38. Isolation of Severe Fever with Thrombocytopenia Syndrome Virus from Various Tick Species in Area with Human Severe Fever with Thrombocytopenia Syndrome Cases.

Author

Sato Y, Mekata H, Sudaryatma PE, Kirino Y, Yamamoto S, Ando S, Sugimoto T, and Okabayashi T

Subjects
Animals, Humans, Phylogeny, Bunyaviridae Infections epidemiology, Bunyaviridae Infections veterinary, Ixodidae, Phlebovirus genetics, Severe Fever with Thrombocytopenia Syndrome veterinary, Tick-Borne Diseases epidemiology, Tick-Borne Diseases veterinary, Ticks
Abstract

Severe fever with thrombocytopenia syndrome (SFTS), caused by Dabie bandavirus , generally called SFTS virus (SFTSV), is an emerging zoonosis in East Asia. In Japan, 50-100 cases of SFTS have been reported each year since the first case was reported in 2013. SFTS is a tick-borne infectious disease, and SFTSV has been isolated from ticks in China and South Korea. Haemaphysalis longicornis and Amblyomma testudinarium are considered the primary vectors in Japan. However, the other tick species seldom feeding on humans might also play an important role in maintaining the virus in nature. In this study, we collected ticks on vegetation around the location where two SFTS patients were estimated to have been infected in Miyazaki Prefecture, Japan, isolated live SFTSV, and performed a phylogenetic analysis. A total of 257 ticks were collected, and SFTSV RNA was detected in 19.5% (9/46) of tick pools. A total of 10 infectious SFTSVs were successfully isolated from A. testudinarium , Haemaphysalis flava , Haemaphysalis formosensis , Haemaphysalis hystricis , and Haemaphysalis megaspinosa . Furthermore, the whole viral sequences isolated from ticks were highly homologous to sequences isolated from SFTS patients in the same sampling area in the past. These results suggest that SFTSVs are maintained in these tick species in the sampling area and sporadically transmitted to humans. Surveillance of SFTSV in ticks provides important information about the risk of incidental transmission to humans.

Published
2021
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