1. Effects of L-arginine on various types of pain sensitivity.
- Author
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Severyanova LA, Bobyntsev II, Kir'yanova NA, and Dolgintsev ME
- Subjects
- Animals, Arginine administration & dosage, Electric Stimulation, Hot Temperature, Injections, Intraperitoneal, Male, Pain Measurement, Rats, Rats, Wistar, Arginine pharmacology, Pain Threshold drug effects
- Abstract
Intraperitoneal injection of L-arginine to male Wistar rats 12 min before the start of the experiment produced a nociceptive effect on models of electrocutaneous stimulation of the tail or hot-plate test and increased nociceptive behavior due to high sensitivity of supraspinal nociceptive structures to this compound. The nociceptive effect of this amino acid was more pronounced and persistent under conditions of electrocutaneous stimulation.
- Published
- 2006
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