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690 results on '"Kintscher, Ulrich"'

5. Kommentar zum Konsensuspapier zur renalen Denervation der Arbeitsgruppe Hypertonie der European Society of Cardiology (ESC) und der European Association of Percutaneous Cardiovascular Interventions (EAPCI)

Author

Halbach, Marcel, Boer, Jana, Böhm, Michael, Busch, Sonia, Dörr, Oliver, Elsässer, Albrecht, Erbel, Christian, Galle, Jan-Christoph, Kintscher, Ulrich, Limbourg, Florian P., Reuter, Hannes, Rump, Lars C., Schmieder, Roland, Schunkert, Heribert, van der Giet, Markus, Weil, Joachim, and Mahfoud, Felix

Published
2023
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8. Systems Biology Approach Uncovers Candidates for Liver-Heart Interorgan Crosstalk in HFpEF.

Author

Strocchi, Stefano, Luo Liu, Rongling Wang, Häseli, Steffen P., Capone, Federico, Bode, David, Nambiar, Natasha, Eroglu, Tolga, Padilla, Leandro Santiago, Farrelly, Catherine, Vacca, Antonio, Mascagni, Marianna, Oeing, Christian U., Kintscher, Ulrich, Jung, Simone, Diezel, Saskia A., Liévano Contreras, Sarah V., Mingqi Zhou, Seldin, Marcus, and Schiattarella, Gabriele G.

Published
2024
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11. Kriterien der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e. V. (DGK), der Deutschen Hochdruckliga e. V. DHL®/Deutschen Gesellschaft für Hypertonie und Prävention und der Deutschen Gesellschaft für Nephrologie (DGfN) zur Zertifizierung von „Renale-Denervations-Zentren (RDZ)“ – Update

Author

Mahfoud, Felix, Galle, Jan, Schunkert, Heribert, Schmieder, Roland E., Rump, Lars C., Limbourg, Florian P., van der Giet, Markus, Elsässer, Albrecht, Kintscher, Ulrich, Böhm, Michael, and Weil, Joachim

Published
2021
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15. An altered plasma lipidome–phenome network characterizes heart failure with preserved ejection fraction.

Author

Jovanovic, Nina, Foryst‐Ludwig, Anna, Klose, Christian, da Conceicao, Cristina Rozados, Alasfar, Lina, Birkner, Till, Forslund, Sofia K., Kintscher, Ulrich, and Edelmann, Frank

Subjects
LEFT ventricular hypertrophy, BRAIN natriuretic factor, HEART failure, VENTRICULAR ejection fraction, BLOOD lipids, DIASTOLIC blood pressure
Abstract

Aims: Heart failure with preserved ejection fraction (HFpEF) is a multifactorial, multisystemic syndrome that involves alterations in lipid metabolism. This study aimed to test whether distinct plasma lipid profiles or lipid entities or both are associated with clinical and functional echocardiographic parameters in HFpEF. Methods and results: We examined the human plasma lipidome in HFpEF patients (n = 18) with left ventricular ejection fraction ≥50% and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) >125 pg/mL and control subjects (n = 12) using mass spectrometry‐based shotgun lipidomics. The cohort included 8 women and 22 men with average age of 67.8 ± 8.6 SD. The control and disease groups were not significantly different with respect to age, body mass index, systolic and diastolic blood pressure, and waist‐to‐hip ratio. The disease group experienced more fatigue (P < 0.001), had more often coronary artery disease (P = 0.04), and received more medications (beta‐blockers, P < 0.001). The disease group had significantly different levels of HFpEF‐relevant parameters, including NT‐proBNP (P < 0.001), left ventricular mass index (P = 0.005), left atrial volume index (P = 0.001), and left ventricular filling index (P < 0.001), and lower left ventricular end‐diastolic diameter (P = 0.014), with no difference in left ventricular ejection fraction. Significant differences in lipid profiles between HFpEF patients and controls could not be detected, including no significant differences in abundance of circulating lipids binned by carbon chain length or by double bonds, nor at the level of individual lipid species. However, there was a striking correlation between selected lipids with smoking status that was independent of disease status, as well as between specific lipids and hyperlipidaemia [with corresponding significance of either false discovery rate (FDR) <0.1 or FDR < 0.01]. In an exploratory network analysis of correlations, we observed significantly stronger correlations within the HFpEF group between individual lipids from the cholesterol ester and phosphatidylcholine (PC) classes and clinical/echocardiographic parameters such as left atrial volume index, left ventricular end‐diastolic diameters, and heart rate (FDR < 0.1). In contrast, the control group showed significantly stronger negative correlations (FDR < 0.1) between individual species from the PC and sphingomyelin classes and left ventricular mass index or systolic blood pressure. Conclusions: We did not find significant direct associations between plasma lipidomic parameters and HFpEF and therefore could not conclude that any specific lipids are biomarkers of HFpEF. The validation in larger cohort is needed to confidently conclude the absence of first‐order associations. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Accurate assessment of LV function using the first automated 2D-border detection algorithm for small animals - evaluation and application to models of LV dysfunction

Author

Grune, Jana, Ritter, Daniel, Kräker, Kristin, Pappritz, Kathleen, Beyhoff, Niklas, Schütte, Till, Ott, Christiane, John, Cathleen, van Linthout, Sophie, Tschöpe, Carsten, Dechend, Ralf, Muller, Dominik N., Haase, Nadine, Grune, Tilman, Kintscher, Ulrich, and Kuebler, Wolfgang M.

Published
2019
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38. Inflammatory Pathways Regulated by Tumor Necrosis Receptor–Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity

Author

Anto Michel, Nathaly, Colberg, Christian, Buscher, Konrad, Sommer, Björn, Pramod, Akula Bala, Ehinger, Erik, Dufner, Bianca, Hoppe, Natalie, Pfeiffer, Katharina, Marchini, Timoteo, Willecke, Florian, Stachon, Peter, Hilgendorf, Ingo, Heidt, Timo, von zur Muhlen, Constantin, von Elverfeldt, Dominik, Pfeifer, Dietmar, Schüle, Roland, Kintscher, Ulrich, Brachs, Sebastian, Ley, Klaus, Bode, Christoph, Zirlik, Andreas, and Wolf, Dennis

Published
2018
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39. Purinergic receptor Y2 (P2Y2)- dependent VCAM-1 expression promotes immune cell infiltration in metabolic syndrome

Author

Merz, Julian, Albrecht, Philipp, von Garlen, Sunaina, Ahmed, Ibrahim, Dimanski, Daniel, Wolf, Dennis, Hilgendorf, Ingo, Härdtner, Carmen, Grotius, Katja, Willecke, Florian, Heidt, Timo, Bugger, Heiko, Hoppe, Natalie, Kintscher, Ulrich, von zur Mühlen, Constantin, Idzko, Marco, Bode, Christoph, Zirlik, Andreas, and Stachon, Peter

Published
2018
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43. Assessment of Myocardial Microstructure in a Murine Model of Obesity-Related Cardiac Dysfunction by Diffusion Tensor Magnetic Resonance Imaging at 7T

Author

Lohr, David, primary, Thiele, Arne, additional, Stahnke, Max, additional, Braun, Vera, additional, Smeir, Elia, additional, Spranger, Joachim, additional, Brachs, Sebastian, additional, Klopfleisch, Robert, additional, Foryst-Ludwig, Anna, additional, Schreiber, Laura M., additional, Kintscher, Ulrich, additional, and Beyhoff, Niklas, additional

Published
2022
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45. Assessment of Myocardial Microstructure in a Murine Model of Obesity-Related Cardiac Dysfunction by Diffusion Tensor Magnetic Resonance Imaging at 7T

Author

Lohr, David, Thiele, Arne, Stahnke, Max, Braun, Vera, Smeir, Elia, Spranger, Joachim, Brachs, Sebastian, Klopfleisch, Robert, Foryst-Ludwig, Anna, Schreiber, Laura M., Kintscher, Ulrich, and Beyhoff, Niklas

Subjects
obesity, high-fat diet, cardiac dysfunction, obesity-related cardiac dysfunction, magnetic resonance imaging, diffusion tensor imaging, cardiac adipose tissue, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Background: Obesity exerts multiple deleterious effects on the heart that may ultimately lead to cardiac failure. This study sought to characterize myocardial microstructure and function in an experimental model of obesity-related cardiac dysfunction. Methods: Male C57BL/6N mice were fed either a high-fat diet (HFD; 60 kcal% fat, n = 12) or standard control diet (9 kcal% fat, n = 10) for 15 weeks. At the end of the study period, cardiac function was assessed by ultra-high frequency echocardiography, and hearts were processed for further analyses. The three-dimensional myocardial microstructure was examined ex vivo at a spatial resolution of 100 × 100 × 100 μm3 by diffusion tensor magnetic resonance imaging (DT-MRI) at 7T. Myocardial deformation, diffusion metrics and fiber tract geometry were analyzed with respect to the different myocardial layers (subendocardium/subepicardium) and segments (base/mid-cavity/apex). Results were correlated with blood sample analyses, histopathology, and gene expression data. Results: HFD feeding induced significantly increased body weight combined with a pronounced accumulation of visceral fat (body weight 42.3 ± 5.7 vs. 31.5 ± 2.2 g, body weight change 73.7 ± 14.8 vs. 31.1 ± 6.6%, both P < 0.001). Obese mice showed signs of diastolic dysfunction, whereas left-ventricular ejection fraction and fractional shortening remained unchanged (E/e’ 41.6 ± 16.6 vs. 24.8 ± 6.0, P < 0.01; isovolumic relaxation time 19 ± 4 vs. 14 ± 4 ms, P < 0.05). Additionally, global longitudinal strain was reduced in the HFD group (−15.1 ± 3.0 vs. −20.0 ± 4.6%, P = 0.01), which was mainly driven by an impairment in basal segments. However, histopathology and gene expression analyses revealed no myocardial fibrosis or differences in cardiomyocyte morphology. Mean diffusivity and eigenvalues of the diffusion tensor were lower in the basal subepicardium of obese mice as assessed by DT-MRI (P < 0.05). The three-dimensional fiber tract arrangement of the left ventricle (LV) remained preserved. Conclusion: Fifteen weeks of high-fat diet induced alterations in myocardial diffusion properties in mice, whereas no remodeling of the three-dimensional myofiber arrangement of the LV was observed. Obese mice showed reduced longitudinal strain and lower mean diffusivity predominantly in the left-ventricular base, and further investigation into the significance of this regional pattern is required.

Published
2021

49. Finerenone Reduces Renal RORγt γδ T Cells and Protects against Cardiorenal Damage

Author

Luettges, Katja, primary, Bode, Marlies, additional, Diemer, Jan Niklas, additional, Schwanbeck, Juliane, additional, Wirth, Eva K., additional, Klopfleisch, Robert, additional, Kappert, Kai, additional, Thiele, Arne, additional, Ritter, Daniel, additional, Foryst-Ludwig, Anna, additional, Kolkhof, Peter, additional, Wenzel, Ulrich Otto, additional, and Kintscher, Ulrich, additional

Published
2022
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50. Spontaneous Degenerative Aortic Valve Disease in New Zealand Obese Mice

Author

Ott, Christiane, primary, Pappritz, Kathleen, additional, Hegemann, Niklas, additional, John, Cathleen, additional, Jeuthe, Sarah, additional, McAlpine, Cameron S., additional, Iwamoto, Yoshiko, additional, Lauryn, Jonathan H., additional, Klages, Jan, additional, Klopfleisch, Robert, additional, Van Linthout, Sophie, additional, Swirski, Fil, additional, Nahrendorf, Matthias, additional, Kintscher, Ulrich, additional, Grune, Tilman, additional, Kuebler, Wolfgang M., additional, and Grune, Jana, additional

Published
2021
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