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4. A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1

Author

Vijayakrishnan, J, Kumar, R, Henrion, M YR, Moorman, A V, Rachakonda, P S, Hosen, I, da Silva Filho, M I, Holroyd, A, Dobbins, S E, Koehler, R, Thomsen, H, Irving, J A, Allan, J M, Lightfoot, T, Roman, E, Kinsey, S E, Sheridan, E, Thompson, P D, Hoffmann, P, Nöthen, M M, Heilmann-Heimbach, S, Jöckel, K H, Greaves, M, Harrison, C J, Bartram, C R, Schrappe, M, Stanulla, M, Hemminki, K, and Houlston, R S

Published
2017
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9. Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study.

Author

Gattermann N., Finelli C., Della Porta M., Fenaux P., Ganser A., Guerci-Bresler A., Schmid M., Taylor K., Vassilieff D., Habr D., Domokos G., Roubert B., Rose C., Agaoglu L., Alimena G., Alonso D., Ame S., Angelucci E., Arrizabalaga B., Athanasiou-Metaxa M., Augustson B., Aydinok Y., Baba A., Baccarani M., Beck J., Beris P., Beyne-Rauzy O., Birgens H., Bordessoule D., Borgna-Pignatti C., Bosly A., Bouabdallah K., Bowden D., Bowen D., Bron D., Cappellini M.D., Capra M., Cartron G., Cazzola M., Chalkias C., Chan L.L., Chancharunee S., Chapman C., Charoenkwan P., Chasapopoulou E., Cheze S., Chuansumrit A., Cianciulli P., Dauriac C., Delforge M., Dolken G., Dombret H., Duyster J., Economopoulos T., Ehninger G., Elalfy M., El-Beshlawy A., Enggaard L., Fillet G., Filosa A., Forni G., Galanello R., Gastl G., Giraudier S., Goldfarb A., Grigg A., Gumruk F., Ha S.Y., Haase D., Heinrich B., Hertzberg M., Ho J., Hsu H.-C., Huang S., Hunault-Berger M., Inusa B., Jaulmes D., Jensen J., Kattamis A., Kilinc Y., Kim K.-H., Kinsey S., Kjeldsen L., Koren A., Lai M.E., Lai Y., Lee J.-W., Lee K.-H., Lee S.-H., Legros L., Li C., Li C.-K., Li Q., Lin K.-H., Linkesch W., Lubbert M., Lutz D., Mohamed Thalha A.J., Mufti G., Muus P., Nobile F., Papadopoulos N., Perrotta S., Petrini M., Pfeilstocker M., Piga A., Poole J., Porter J.B., Pungolino E., Quarta G., Ravoet C., Jolimont Lobbes H.H., Remacha A.F., Roy L., Saglio G., Sanz G., Schmugge M., Schots H., Secchi G., Seymour J.F., Shah F., Shah H., Shen Z., Slama B., Sutcharitchan P., Taher A., Tamary H., Tesch H.-J., Thein S.L., Troncy J., Villegas A., Viprakasit V., Wainwright L., Wassmann B., Wettervald M., Will A., Wormann B., Wright J., Yeh S.-P., Yoon S.-S., Zoumbos N.C., Zweegman S., Gattermann N., Finelli C., Della Porta M., Fenaux P., Ganser A., Guerci-Bresler A., Schmid M., Taylor K., Vassilieff D., Habr D., Domokos G., Roubert B., Rose C., Agaoglu L., Alimena G., Alonso D., Ame S., Angelucci E., Arrizabalaga B., Athanasiou-Metaxa M., Augustson B., Aydinok Y., Baba A., Baccarani M., Beck J., Beris P., Beyne-Rauzy O., Birgens H., Bordessoule D., Borgna-Pignatti C., Bosly A., Bouabdallah K., Bowden D., Bowen D., Bron D., Cappellini M.D., Capra M., Cartron G., Cazzola M., Chalkias C., Chan L.L., Chancharunee S., Chapman C., Charoenkwan P., Chasapopoulou E., Cheze S., Chuansumrit A., Cianciulli P., Dauriac C., Delforge M., Dolken G., Dombret H., Duyster J., Economopoulos T., Ehninger G., Elalfy M., El-Beshlawy A., Enggaard L., Fillet G., Filosa A., Forni G., Galanello R., Gastl G., Giraudier S., Goldfarb A., Grigg A., Gumruk F., Ha S.Y., Haase D., Heinrich B., Hertzberg M., Ho J., Hsu H.-C., Huang S., Hunault-Berger M., Inusa B., Jaulmes D., Jensen J., Kattamis A., Kilinc Y., Kim K.-H., Kinsey S., Kjeldsen L., Koren A., Lai M.E., Lai Y., Lee J.-W., Lee K.-H., Lee S.-H., Legros L., Li C., Li C.-K., Li Q., Lin K.-H., Linkesch W., Lubbert M., Lutz D., Mohamed Thalha A.J., Mufti G., Muus P., Nobile F., Papadopoulos N., Perrotta S., Petrini M., Pfeilstocker M., Piga A., Poole J., Porter J.B., Pungolino E., Quarta G., Ravoet C., Jolimont Lobbes H.H., Remacha A.F., Roy L., Saglio G., Sanz G., Schmugge M., Schots H., Secchi G., Seymour J.F., Shah F., Shah H., Shen Z., Slama B., Sutcharitchan P., Taher A., Tamary H., Tesch H.-J., Thein S.L., Troncy J., Villegas A., Viprakasit V., Wainwright L., Wassmann B., Wettervald M., Will A., Wormann B., Wright J., Yeh S.-P., Yoon S.-S., Zoumbos N.C., and Zweegman S.

Abstract

The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ~50% were chelation-naive. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-naive or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. © 2010 Elsevier Ltd.

Published
2021

12. The impact of a regional care bundle on maternal breast milk use in preterm infants: outcomes of the East of England quality improvement programme

Author

Battersby, C, Santhakumaran, S, Upton, M, Radbone, L, Birch, J, Modi, N, Sharief, N, Kadalraja, R, Mahesh Babu, R N, Dalton, S, Dixon, H, James, M, Jayalal, V, Kefas, J, Skinner, S, Dyke, M, Babiker, S, Soe, T, Rubin, S, Ogilvy-Stuart, A, Khan, A, Ramesh, C, Evans, I, Rackham, O, Brearey, S, Thirumurugan, A, Losa, I, McBride, T, Zipitis, C, Amegavie, L, Moise, J, Zipitis, C, Settle, P, Edi-Osagie, N, Heal, C, Birch, J, Al-Zidgali, F, Hasib, A, Kisat, H, Soe, A, Kumar, M, Fedee, J, Lama, M, Gupta, R, Rawlingson, de Boer, RC, Rao, P, Thompson, S, Manzoor, A, Blake, K, Upponi, A, Bhaduri, AK, Halahakoon, C, Deshpande, Mohite, A, Tewary, KK, Palmer, K, Gallagher, A, Nycyk, J, Simmons, P, Morgan, I, Underhill, HC, Wickham, T, van Someren, V, Watkin, S, Blumberg, R, Aladangady, N, Alsford, L, Sullivan, C, Hamdan, S, Adiotomre, P, Ahmed, JS, Foo, A, Talekar, R, Gibson, A, Thomas, M, Mathur, R, Cruwys, M, Mannix, P, Ariff, H, Whitehead, Ben-Hamida, M, Garbasa, M, Lal, M, Bosman, D, Fenton, A, Bolton, AR, Abu-Harb, M, Reichert, B, Olivier, J, Larson, J, Cherinet, Y, Munyard, P, Osbourne, N, Raman, M, Watts, T, Hannam, Walter, S, Kuna, J, Chang, YL, Shephard, R, Lindo, D, Huddy, C, Wigfield, R, Wylie, P, Misra, I, Shettihalli, N, Khashu, M, Hall, M, Groves, C, de Halpert, P, Schapira, D, Kinsey, S, Butterworth, S, Brennan, N, Whitehead, G, Sanghavi, R, Whincup, G, Khader, K, Mallik, A, Amess, P, Godden, C, Reynolds, P, Brennan, N, Noble, V, Rao, AS, Wardle, S, Ratnayaka, M, Holman, J, Zengeya, S, Jones, S, Wach, R, Tooley, J, Mann, RJ, Eaton, M, Babirecki, M, Seal, S, Schwarz, K, Gibson, D, Jampala, C, Pairaudeau, P, Miall, L, Qunib, M, Millman, G, Abbott, Jane, Ashby, Deborah, Brocklehurst, Peter, Costeloe, Kate, Draper, Elizabeth, Goldacre, Michael, Kemp, Jacquie, Majeed, Azeem, Petrou, Stavros, Wilkinson, Andrew, Young, Alys, Vasu, Vimal, Dopran, Jacquie, Dorling, Jon, and Allwood, Alex

Published
2014
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13. Retinopathy of prematurity in English neonatal units: a national population-based analysis using NHS operational data

Author

Wong, Hilary S, Santhakumaran, Shalini, Statnikov, Yevgeniy, Gray, Daniel, Watkinson, Michael, Modi, Neena, Kadalraja, R, Kefas, J, Srinnel, S, Ramesh, C, Rackham, O, Brearey, S, Thirumurugan, A, Losa, I, McBride, T, Zipitis, C, Amegavie, L, Moise, J, Zipitis, C, Yadan, M, Maddock, N, Moise, J, Edi-Osagie, N, Heal, C, Birch, J, Al-Zidgali, F, Hasib, A, Kisat, H, Soe, A, Long, D, Fedee, J, Lama, M, Gupta, R, Rawlingson de Boer, RC, Rao, P, Blake, K, Bhaduri, AK, Halahakoon, C, Deshpande Mohite, A, Tewary, KK, Palmer, K, Gallagher, A, Nycyk, J, Simmons, P, Morgen, I, Underhill, HC, Mahesh Babu, R N, Dalton, S, Dixon, H, James, M, Jayalal, V, Dyke, M, Babiker, S, Soe, T, Rubin, S, Ogilvy-Stuart, A, Evans, I, Wickham, T, van Someren, V, Watkin, S, Blumberg, R, Sharief, N, Aladangady, N, Sharma, B, Sullivan, C, Alsford, L, Sharma, B, Khan, A, Hamdan, S, Ahmed, JS, Foo, A, Talekar, R, Adiotomre, P, Gibson, A, Thomas, M, Mathur, R, Cruwys, M, Mannix, P, Ariff, H, Garbasa, M, Lal, M, Bosman, D, Fenton, A, Bolton, AR, Abu-Harb, M, Verber, I, Olivier, J, Larson, J, Cherinet, Y, Munyard, P, Osbourne, N, Raman, M, Watts, T, Hannam, S, Walter, S, Kuna, J, Chang, YL, Shephard, R, Lindo, D, Calvert, S, Wigfield, R, Wylie, P, Misra, I, Shettihalli, N, Khashu, M, Hall, M, Groves, C, de Halpert, P, Schapira, D, Kinsey, S, Butterworth, S, Garg, A, Whitehead, G, Sanghavi, R, Whincup, G, Khader, K, Mallik, A, Amess, P, Godden, C, Reynolds, P, Brannan, N, Noble, V, Rao, AS, Wardle, S, Ratnayaka, M, Holman, J, Zengeya, S, Jones, S, Wach, R, Tooley, J, Mann, RJ, Eaton, M, Babirecki, M, Seal, S, Schwartz, K, Gibson, D, Jampala, C, Pairaudeau, P, Miall, L, Shyamannr, K, and Qunib, M

Published
2014
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16. Neonatal Antifungal Consumption Is Dominated by Prophylactic Use; Outcomes From The Pediatric Antifungal Stewardship: Optimizing Antifungal Prescription Study

Author

Ferreras-Antolín, L, Irwin, A, Atra, A, Dermirjian, A, Drysdale, SB, Emonts, M, McMaster, P, Paulus, S, Patel, S, Kinsey, S, Vergnano, S, Whittaker, E, and Warris, A

Abstract

BACKGROUND: Diagnostic challenges combined with the vulnerability of neonates to develop invasive candidiasis (IC) may lead to antifungal administration in the absence of IC. A modified point-prevalence study was performed to obtain an improved insight and understanding of antifungal prescribing in this specific patient population. METHODS: Neonates and infants ≤90 days of age receiving systemic antifungals from 12 centers in England were included. Data were collected prospectively during 26 consecutive weeks and entered into an online REDCap database. RESULTS: Two hundred eighty neonates and infants were included, the majority ≤1 month of age (68.2%). Prematurity was the commonest underlying condition (68.9%). Antifungals were prescribed for prophylactic reason in 79.6%; of those, 64.6% and 76.3% were extreme low birth weight infants and prematurely born neonates, respectively. Additional risk factors were present in almost all patients, but only 44.7% had ≥3 risk factors rendering them more susceptible to develop IC. Nonpremature and non extremely low birth weight premature infants only scored ≥3 risk factors in 32.6% and 15%, respectively. Fluconazole was the most common antifungal used (76.7% of all prescriptions), and commonly underdosed as treatment. The number of microbiological proven IC was low, 5.4%. CONCLUSIONS: Neonatal antifungal prophylaxis is commonly prescribed outside the recommendations based on known risk profiles. Fluconazole is the main antifungal prescribed in neonates and infants, with underdosing frequently observed when prescribed for treatment. Number of proven IC was very low. These observations should be taken into consideration to develop a national pediatric Antifungal Stewardship program aiming to guide rational prescribing.

Published
2019

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