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Introduction and objective: Hallux valgus is a common deformity (about 23%) in adult population. Deformation of the fist ray and pain causes gait pattern changes and lower life satisfaction. There are many suggestions how to treat bunion. The method of first choice is conservative treatment. One of the most popular option are orthoses of different kinds and functions. The aim of this article is to review the conservative methods of treatment and orthotic management of bunionsand its effectiveness. Materials and methods: PubMed and Google Scholar databases were searched. The criteria for qualifying the articles for the review were the following keywords: bunion, hallux valgus, orthoses, foot deformity. 21 articles from 2018 to 2023 were analyzed. Description of the state of knowledge: Conservative treatment includes orthoses, shoe modification, analgesics, and exercises. But the most popular are the first two methods. There are many types of orthoses used for hallux valgus, i.e. dynamic and static orthoses, separators, insoles and splints. Orthoses are used to reduce hallux valgus angle (HVA) and pain, and inhibit the progression of deformity in a long term. Studies show that dynamic orthoses have a greater effect on reducing HVA and pain compared to static orthoses. In addition, they are more frequently and willingly chosen by patients. Also, toe separators have a significant impact on minimizing pain and improving toe alignment. Summary: Significant reduction of pain and HVA are observed in both short-term and long-term effects when using dynamic orthoses and toe separators. Dynamic orthoses are also more likely to be chosen by patients for their convenience. However, all types of orthoses are beneficial to patients' well-being. A change of footwear also helps to stop the progression of the deformity and prevents recurrence after surgery.

Primary sclerosing cholangitis (PSC) is an inflammatory, cholestatic and progressively fibrotic liver disease devoid of effective medical intervention. PBC is a presumed immune-mediated liver disease of middle-aged women associated with significant morbidity and mortality. People living with PBC are frequently symptomatic, experiencing a quality-of-life burden dominated by fatigue, itch, abdominal pain, and sicca complex. Many drugs have been studied for treatment, including agents with choleretic and immunosuppressive properties. Future PBC licensed therapy will likely include peroxisome proliferator activated receptor (PPAR) pathway agonists, including specific PPAR-delta agonism (seladelpar), as well as elafibrinor and saroglitazar (both with broader PPAR agonism). Effective therapy reduces the need for transplantation and improves life expectancy.

Vitamin D is an essential nutrient that plays an important role in promoting overall health and well-being. Deficiencies of nutrients such as vitamin D are common in patients with autoimmune diseases. The incidence of these conditions is constantly increasing. As a result, patients are exposed to severe symptoms and discomfort in daily functioning. The causes, as well as the symptoms and complications they cause, are diverse, making diagnosis and treatment difficult. Therefore, during the clinical care of patients with AID, possible micronutrient deficiencies should be taken into account and, if observed, they should be treated with controlled supplementation. The aim of this article was to review the literature on the impact of low vitamin D status on the development of autoimmune diseases in the field of endocrinology.

Introduction and Purpose: Stroke is a common complication of one of the most common cardiac arrhythmias, atrial fibrillation. The aim of this study is to provide key information about these diseases and to compare the drugs used to prevent stroke. Materials and methods: A literature search was conducted using the medical databases PubMed and Google Scholar. Articles were retrieved in English, employing the key words: “VKA “, „NOAC”, „atrial fibrillation”, „anticoagulants“ and „stroke” appropriate configurations. Conclusions: According to the recommendations and available medical literature, the use of NOACs is usually the most appropriate choice for stroke prevention in patients with atrial fibrillation. However there are also clinical situations, in which the use of VKAs would be more appropriate.

Obesity is a multifactorial chronic disease with complex pathogenesis. Its causes are considered to be genetic, biological, epigenetic, environmental, developmental and behavioral factors leading to excessive caloric intake and, consequently, weight gain. As body weight increases, the risk of developing many chronic diseases increases and, as a result, life expectancy decreases. The basis of obesity treatment is the introduction of changes in behavior and lifestyle modification, based primarily on the adoption of a healthy, balanced diet with a caloric deficit, regular physical activity and limiting sedentary time. If they are ineffective, pharmacological methods are considered and, if necessary, surgical procedures are performed. Nowadays, more and more attention is paid to obesity as a multifactorial disease that must be effectively treated. It is not only an aesthetic problem but also a serious disease that can lead to premature death. Our work focuses on a review of current methods in the treatment of obesity, with particular attention to the latest pharmacological methods.