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We present the first observations of seismic waves propagating through the core of Mars. These observations, made using seismic data collected by the InSight geophysical mission, have allowed us to construct the first seismically constrained models for the elastic properties of Mars' core. We observe core-transiting seismic phase SKS from two farside seismic events detected on Mars and measure the travel times of SKS relative to mantle traversing body waves. SKS travels through the core as a compressional wave, providing information about bulk modulus and density. We perform probabilistic inversions using the core-sensitive relative travel times together with gross geophysical data and travel times from other, more proximal, seismic events to seek the equation of state parameters that best describe the liquid iron-alloy core. Our inversions provide constraints on the velocities in Mars' core and are used to develop the first seismically based estimates of its composition. We show that models informed by our SKS data favor a somewhat smaller (median core radius = 1,780 to 1,810 km) and denser (core density = 6.2 to 6.3 g/cm3) core compared to previous estimates, with a P-wave velocity of 4.9 to 5.0 km/s at the core-mantle boundary, with the composition and structure of the mantle as a dominant source of uncertainty. We infer from our models that Mars' core contains a median of 20 to 22 wt% light alloying elements when we consider sulfur, oxygen, carbon, and hydrogen. These data can be used to inform models of planetary accretion, composition, and evolution.

Constraining the thermal and compositional state of the mantle is crucial for deciphering the formation and evolution of Mars. Mineral physics predicts that Mars' deep mantle is demarcated by a seismic discontinuity arising from the pressure-induced phase transformation of the mineral olivine to its higher-pressure polymorphs, making the depth of this boundary sensitive to both mantle temperature and composition. Here, we report on the seismic detection of a midmantle discontinuity using the data collected by NASA's InSight Mission to Mars that matches the expected depth and sharpness of the postolivine transition. In five teleseismic events, we observed triplicated P and S waves and constrained the depth of this discontinuity to be 1,006 [Formula: see text] 40 km by modeling the triplicated waveforms. From this depth range, we infer a mantle potential temperature of 1,605 [Formula: see text] 100 K, a result consistent with a crust that is 10 to 15 times more enriched in heat-producing elements than the underlying mantle. Our waveform fits to the data indicate a broad gradient across the boundary, implying that the Martian mantle is more enriched in iron compared to Earth. Through modeling of thermochemical evolution of Mars, we observe that only two out of the five proposed composition models are compatible with the observed boundary depth. Our geodynamic simulations suggest that the Martian mantle was relatively cold 4.5 Gyr ago (1,720 to 1,860 K) and are consistent with a present-day surface heat flow of 21 to 24 mW/m2.

A national focus on Diversity, Equity, and Inclusion (DEI) has increased public awareness and acknowledgement of challenges faced by members of Underrepresented Minority (URM) groups pursuing academic careers. This case study of a multi-institutional partnership explores the development, implementation, and evolution of a replicable model to transition a cohort of STEM URM dissertators into the professoriate. The model structured cohort engagement around an Individual Development Plan (IDP), cohort participant engagement with multiple mentors, monthly scholarly learning community meetings, research and teaching immersion experiences at Historically Black Colleges and Universities (HBCUs) and international institutions, and support and training around transferable skills necessary for job preparation and success, such as grant development, job search, portfolio preparation, interview skills, and online course development. Program evaluation results emphasized the evolution of collaborative practice among stakeholders in promoting the success of the model and among cohort participants as these participants transitioned into academic careers. Discussion of best practices to design and fine-tune the model included engagement of cohort participants in refining the implementation of the model activities, offering personalized services to the cohort members, and engaging research and practitioner communities using multiple dissemination strategies. The results of this work include publicly available virtual resources curated as part of the dissemination plan that can be explored for implementation at other institutions and use by individuals.

Analyses of seismic data from the InSight mission have provided the first in situ constraints on the thickness of the crust of Mars. These crustal thickness constraints are currently limited to beneath the lander that is located in the northern lowlands, and we use gravity and topography data to construct global crustal thickness models that satisfy the seismic data. These models consider a range of possible mantle and core density profiles, a range of crustal densities, a low-density surface layer, and the possibility that the crustal density of the northern lowlands is greater than that of the southern highlands. Using the preferred InSight three-layer seismic model of the crust, the average crustal thickness of the planet is found to lie between 30 and 72 km. Depending on the choice of the upper mantle density, the maximum permissible density of the northern lowlands and southern highlands crust is constrained to be between 2,850 and 3,100 kg m−3. These crustal densities are lower than typical Martian basaltic materials and are consistent with a crust that is on average more felsic than the materials found at the surface. We argue that a substantial portion of the crust of Mars is a primary crust that formed during the initial differentiation of the planet. Various hypotheses for the origin of the observed intracrustal seisimic layers are assessed, with our preferred interpretation including thick volcanic deposits, ejecta from the Utopia basin, porosity closure, and differentiation products of a Borealis impact melt sheet.

Variations in Global Positioning Systems (GPSs) have been used for tracking users' locations. However, when location tracking is needed for an indoor space, such as a house or building, then an alternative means of precise position tracking may be required because GPS signals can be severely attenuated or completely blocked. In our approach to indoor positioning, we developed an indoor localization system that minimizes the amount of effort and cost needed by the end user to put the system to use. This indoor localization system detects the user's room-level location within a house or indoor space in which the system has been installed. We combine the use of Bluetooth Low Energy beacons and a smartwatch Bluetooth scanner to determine which room the user is located in. Our system has been developed specifically to create a low-complexity localization system using the Nearest Neighbor algorithm and a moving average filter to improve results. We evaluated our system across a household under two different operating conditions: first, using three rooms in the house, and then using five rooms. The system was able to achieve an overall accuracy of 85.9% when testing in three rooms and 92.106% across five rooms. Accuracy also varied by region, with most of the regions performing above 96% accuracy, and most false-positive incidents occurring within transitory areas between regions. By reducing the amount of processing used by our approach, the end-user is able to use other applications and services on the smartwatch concurrently. [ABSTRACT FROM AUTHOR]

In vitro (1)H MRS of human bile has shown potential in the diagnosis of various hepatopancreatobiliary (HPB) diseases. Previously, in vivo (1)H MRS of human bile in gallbladder using a 1.5 T scanner demonstrated the possibility of quantification of choline-containing phospholipids (chol-PLs). However, other lipid components such as bile acids play an important role in the pathophysiology of the HPB system. We have employed a higher magnetic field strength (3 T), and a custom-built receive array coil, to improve the quality of in vivo (1)H MRS of human bile in the gallbladder. We obtained significant improvement in the quality of 1D spectra (17 healthy volunteers) using a respiratory-gated PRESS sequence with well distinguished signals for total bile acids (TBAs) plus cholesterol resonating at 0.66 ppm, taurine-conjugated bile acids (TCBAs) at 3.08 ppm, chol-PLs at 3.22 ppm, glycine-conjugated bile acids (GCBAs) at 3.74 ppm, and the amide proton (-NH) arising from GCBAs and TCBAs in the region 7.76-8.05 ppm. The peak areas of these signals were measured by deconvolution, and subsequently the molar concentrations of metabolites were estimated with good accuracy, except for that of TBAs plus cholesterol. The concentration of TBAs plus cholesterol was overestimated in some cases, which could be due to lipid contamination. In addition, we report the first 2D L-COSY spectra of human gallbladder bile in vivo (obtained in 15 healthy volunteers). 2D L-COSY spectra will be helpful in differentiating various biliary chol-PLs in pathological conditions of the HPB system.

Abstract Background New biologic therapies directly injected into the prostate are in clinical trials for prostatic diseases. There is a need to understand distribution of injected therapies as a function of prostatic anatomy, physiology, and device design. Methods A needle with a porous length of customizable-length was tested and its performance compared with a standard needle. Injections of magnetic resonance contrast reagent were placed into ex-vivo human prostates after surgical excision in standard of care therapy for invasive bladder cancer patients. Magnetic resonance images were acquired using sequences to quantify volume delivered, distributed, and backflow. Results Magnetic resonance images analysis revealed heterogeneity distribution with injection into the specimens. There was low resistance to flow along ductal pathways and high resistance to flow into glandular nodules and smooth muscle/fibrous parenchyma. Data confirm previous studies showing injection loss via urethra backflow, urethra, and prostatic ducts. Tissue fraction of dose was significantly higher with porous needle compared with standard needle (p = .03). We found that a greater volume of distribution divided by the amount infused (Vd/Vi) increased by 80% with the porous needle, though no statistically significant association due to small sample size. Conclusions This study demonstrated that prostatic tissue is anatomically heterogenic and limits distribution of needle injection. There is greater distribution in the ex-vivo prostate using a porous needle. The complexity of intra prostatic flow pathways suggests preoperative imaging and pre-treatment planning will enhance therapy.