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1. Computational design of non-porous pH-responsive antibody nanoparticles

Author

Yang, Erin C., Divine, Robby, Miranda, Marcos C., Borst, Andrew J., Sheffler, Will, Zhang, Jason Z., Decarreau, Justin, Saragovi, Amijai, Abedi, Mohamad, Goldbach, Nicolas, Ahlrichs, Maggie, Dobbins, Craig, Hand, Alexis, Cheng, Suna, Lamb, Mila, Levine, Paul M., Chan, Sidney, Skotheim, Rebecca, Fallas, Jorge, Ueda, George, Lubner, Joshua, Somiya, Masaharu, Khmelinskaia, Alena, King, Neil P., and Baker, David

Published
2024
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2. Rapid and automated design of two-component protein nanomaterials using ProteinMPNN

Author

de Haas, Robbert J, Brunette, Natalie, Goodson, Alex, Dauparas, Justas, Yi, Sue Y, Yang, Erin C, Dowling, Quinton, Nguyen, Hannah, Kang, Alex, Bera, Asim K, Sankaran, Banumathi, de Vries, Renko, Baker, David, and King, Neil P

Subjects
Biochemistry and Cell Biology, Biological Sciences, Bioengineering, Biotechnology, Generic health relevance, Models, Molecular, Proteins, Amino Acid Sequence, Nanostructures, Protein Conformation, ProteinMPNN, nanomaterials, protein design
Abstract

The design of protein-protein interfaces using physics-based design methods such as Rosetta requires substantial computational resources and manual refinement by expert structural biologists. Deep learning methods promise to simplify protein-protein interface design and enable its application to a wide variety of problems by researchers from various scientific disciplines. Here, we test the ability of a deep learning method for protein sequence design, ProteinMPNN, to design two-component tetrahedral protein nanomaterials and benchmark its performance against Rosetta. ProteinMPNN had a similar success rate to Rosetta, yielding 13 new experimentally confirmed assemblies, but required orders of magnitude less computation and no manual refinement. The interfaces designed by ProteinMPNN were substantially more polar than those designed by Rosetta, which facilitated in vitro assembly of the designed nanomaterials from independently purified components. Crystal structures of several of the assemblies confirmed the accuracy of the design method at high resolution. Our results showcase the potential of deep learning-based methods to unlock the widespread application of designed protein-protein interfaces and self-assembling protein nanomaterials in biotechnology.

Published
2024

3. Potent neutralization of SARS-CoV-2 variants by RBD nanoparticle and prefusion-stabilized spike immunogens

Author

Miranda, Marcos C., Kepl, Elizabeth, Navarro, Mary Jane, Chen, Chengbo, Johnson, Max, Sprouse, Kaitlin R., Stewart, Cameron, Palser, Anne, Valdez, Adian, Pettie, Deleah, Sydeman, Claire, Ogohara, Cassandra, Kraft, John C., Pham, Minh, Murphy, Michael, Wrenn, Sam, Fiala, Brooke, Ravichandran, Rashmi, Ellis, Daniel, Carter, Lauren, Corti, Davide, Kellam, Paul, Lee, Kelly, Walls, Alexandra C., Veesler, David, and King, Neil P.

Published
2024
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5. A gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge

Author

Edwards, Kristina R., Malhi, Harman, Schmidt, Karina, Davis, Amelia R., Homad, Leah J., Warner, Nikole L., Chhan, Crystal B., Scharffenberger, Samuel C., Gaffney, Karen, Hinkley, Troy, Potchen, Nicole B., Wang, Jing Yang, Price, Jason, McElrath, M. Juliana, Olson, James, King, Neil P., Lund, Jennifer M., Moodie, Zoe, Erasmus, Jesse H., and McGuire, Andrew T.

Published
2024
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8. Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

Author

Wang, Jing Yang, Khmelinskaia, Alena, Sheffler, William, Miranda, Marcos C, Antanasijevic, Aleksandar, Borst, Andrew J, Torres, Susana V, Shu, Chelsea, Hsia, Yang, Nattermann, Una, Ellis, Daniel, Walkey, Carl, Ahlrichs, Maggie, Chan, Sidney, Kang, Alex, Nguyen, Hannah, Sydeman, Claire, Sankaran, Banumathi, Wu, Mengyu, Bera, Asim K, Carter, Lauren, Fiala, Brooke, Murphy, Michael, Baker, David, Ward, Andrew B, and King, Neil P

Subjects
Medical Biotechnology, Biological Sciences, Biomedical and Clinical Sciences, Bioengineering, Vaccine Related, Biotechnology, Nanotechnology, Generic health relevance, Proteins, Nanoparticles, Vaccines, biochemistry, protein design, nanoparticles
Abstract

Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, but in practice, they often secrete poorly. Here we show that designed hydrophobic interfaces that drive nanoparticle assembly are often predicted to form cryptic transmembrane domains, suggesting that interaction with the membrane insertion machinery could limit efficient secretion. We develop a general computational protocol, the Degreaser, to design away cryptic transmembrane domains without sacrificing protein stability. The retroactive application of the Degreaser to previously designed nanoparticle components and nanoparticles considerably improves secretion, and modular integration of the Degreaser into design pipelines results in new nanoparticles that secrete as robustly as naturally occurring protein assemblies. Both the Degreaser protocol and the nanoparticles we describe may be broadly useful in biotechnological applications.

Published
2023

10. Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera

Author

Hutchinson, Geoffrey B., Abiona, Olubukola M., Ziwawo, Cynthia T., Werner, Anne P., Ellis, Daniel, Tsybovsky, Yaroslav, Leist, Sarah R., Palandjian, Charis, West, Ande, Fritch, Ethan J., Wang, Nianshuang, Wrapp, Daniel, Boyoglu-Barnum, Seyhan, Ueda, George, Baker, David, Kanekiyo, Masaru, McLellan, Jason S., Baric, Ralph S., King, Neil P., Graham, Barney S., and Corbett-Helaire, Kizzmekia S.

Published
2023
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11. How do previously inactive individuals restructure their time to 'fit in' morning or evening exercise: a randomized controlled trial

Author

Brooker, Paige G., Gomersall, Sjaan R., King, Neil A., McMahon, Nicholas F., and Leveritt, Michael D.

Subjects
Time management -- Health aspects, Sedentary behavior -- Health aspects, Physical fitness -- Methods, Psychology and mental health
Abstract

The objective of this study was to investigate changes in sedentary and active behaviors when previously inactive adults start exercising in the morning or evening. One-hundred adults with overweight or obesity (BMI [greater than or equal to] 25 kg/m.sup.2) were recruited for a 12-week intervention and randomized to one of three groups: (i) morning exercise (AMEx; 0600-0900); (ii) evening exercise (PMEx; 1600-1900); or (iii) waitlist control. AMEx and PMEx were prescribed self-paced aerobic exercise to achieve a weekly total of 250 min via a combination of supervised and unsupervised training. Sedentary and active behavior times were measured at baseline, mid- and post-intervention using the multimedia activity recall for children and adults. Time spent engaging in physical activity was significantly increased from baseline at both mid- (+ 14-22 min·day.sup.-1) and post-intervention (+ 12-19 min·day.sup.-1), for AMEx and PMEx. At 12-weeks, participants in both morning and evening exercise groups reported increased time spent Sleeping (+ 36 and + 20 min·day.sup.-1, respecitively), and reduced time spent watching TV/playing videogames (- 32 and - 25 min·day.sup.-1, respectively). In response to an exercise stimulus, previously inactive adults make encouraging modifications in how they use their time, and the patterns of change are similar with morning and evening exercise., Author(s): Paige G. Brooker [sup.1] , Sjaan R. Gomersall [sup.1] [sup.2] , Neil A. King [sup.3] , Nicholas F. McMahon [sup.1] , Michael D. Leveritt [sup.1] Author Affiliations: (1) grid.1003.2, [...]

Published
2023
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13. Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase

Author

Lederhofer, Julia, Tsybovsky, Yaroslav, Nguyen, Lam, Raab, Julie E., Creanga, Adrian, Stephens, Tyler, Gillespie, Rebecca A., Syeda, Hubza Z., Fisher, Brian E., Skertic, Michelle, Yap, Christina, Schaub, Andrew J., Rawi, Reda, Kwong, Peter D., Graham, Barney S., McDermott, Adrian B., Andrews, Sarah F., King, Neil P., and Kanekiyo, Masaru

Published
2024
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17. Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses

Author

Ols, Sebastian, Lenart, Klara, Arcoverde Cerveira, Rodrigo, Miranda, Marcos C., Brunette, Natalie, Kochmann, Jana, Corcoran, Martin, Skotheim, Rebecca, Philomin, Annika, Cagigi, Alberto, Fiala, Brooke, Wrenn, Samuel, Marcandalli, Jessica, Hellgren, Fredrika, Thompson, Elizabeth A., Lin, Ang, Gegenfurtner, Florian, Kumar, Azad, Chen, Man, Phad, Ganesh E., Graham, Barney S., Perez, Laurent, Borst, Andrew J., Karlsson Hedestam, Gunilla B., Ruckwardt, Tracy J., King, Neil P., and Loré, Karin

Published
2023
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19. Process development of a SARS-CoV-2 nanoparticle vaccine

Author

Martinez-Cano, Diandra, Ravichandran, Rashmi, Le, Huong, Wong, H. Edward, Jagannathan, Bharat, Liu, Erik J., Bailey, William, Yang, Jane, Matthies, Kelli, Barkhordarian, Hedieh, Shah, Bhavana, Srinivasan, Nithya, Zhang, Jun, Hsu, Angel, Wypych, Jette, Stevens, Jennitte, Piedmonte, Deirdre Murphy, Miranda, Les P., Carter, Lauren, Murphy, Michael, King, Neil P., and Soice, Neil

Published
2023
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21. Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens.

Author

Ueda, George, Antanasijevic, Aleksandar, Fallas, Jorge A, Sheffler, William, Copps, Jeffrey, Ellis, Daniel, Hutchinson, Geoffrey B, Moyer, Adam, Yasmeen, Anila, Tsybovsky, Yaroslav, Park, Young-Jun, Bick, Matthew J, Sankaran, Banumathi, Gillespie, Rebecca A, Brouwer, Philip Jm, Zwart, Peter H, Veesler, David, Kanekiyo, Masaru, Graham, Barney S, Sanders, Rogier W, Moore, John P, Klasse, Per Johan, Ward, Andrew B, King, Neil P, and Baker, David

Subjects
Humans, Glycoproteins, Influenza Vaccines, Antigens, Viral, Cryoelectron Microscopy, Vaccination, Nanoparticles, Immunity, Humoral, B lymphocytes, BL21, E. coli, HEK293F, Lemo21, computational biology, human, immunology, inflammation, systems biology, virus, Antigens, Viral, Immunity, Humoral, Biochemistry and Cell Biology
Abstract

Multivalent presentation of viral glycoproteins can substantially increase the elicitation of antigen-specific antibodies. To enable a new generation of anti-viral vaccines, we designed self-assembling protein nanoparticles with geometries tailored to present the ectodomains of influenza, HIV, and RSV viral glycoprotein trimers. We first de novo designed trimers tailored for antigen fusion, featuring N-terminal helices positioned to match the C termini of the viral glycoproteins. Trimers that experimentally adopted their designed configurations were incorporated as components of tetrahedral, octahedral, and icosahedral nanoparticles, which were characterized by cryo-electron microscopy and assessed for their ability to present viral glycoproteins. Electron microscopy and antibody binding experiments demonstrated that the designed nanoparticles presented antigenically intact prefusion HIV-1 Env, influenza hemagglutinin, and RSV F trimers in the predicted geometries. This work demonstrates that antigen-displaying protein nanoparticles can be designed from scratch, and provides a systematic way to investigate the influence of antigen presentation geometry on the immune response to vaccination.

Published
2020

23. Shift work is associated with an elevated white blood cell count: A systematic review and meta-analysis

Author

Sooriyaarachchi, Piumika, Jayawardena, Ranil, Pavey, Toby, and King, Neil

Subjects
Medical research, Medicine, Experimental, Blood cell count, Inflammation -- Development and progression, Chronic diseases -- Development and progression, Type 2 diabetes -- Development and progression, Environmental issues, Health
Abstract

Byline: Piumika. Sooriyaarachchi, Ranil. Jayawardena, Toby. Pavey, Neil. King The white blood cell (WBC) count increases significantly in reaction to infections and certain chronic diseases. Shift employment increases the risk [...]

Published
2023

24. Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

Author

Dalvie, Neil C., Rodriguez-Aponte, Sergio A., Hartwell, Brittany L., Tostanoski, Lisa H., Biedermann, Andrew M., Crowell, Laura E., Kaur, Kawaljit, Kumru, Ozan S., Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A., Rodrigues, Kristen A., Silva, Murillo, Johnston, Ryan S., Naranjo, Christopher A., Tracey, Mary Kate, Brady, Joseph R., Whittaker, Charles A., Yun, Dongsoo, Brunette, Natalie, Wang, Jing Yang, Walkey, Carl, Fiala, Brooke, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G., Love, Kerry R., Camp, Danielle L., Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B., Volkin, David B., Dubois, Patrice M., Collin, Nicolas, King, Neil P., Barouch, Dan H., Irvine, Darrell J., and Love, J. Christopher

Published
2021

25. Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses

Author

Brinkkemper, Mitch, Veth, Tim S., Brouwer, Philip J.M., Turner, Hannah, Poniman, Meliawati, Burger, Judith A., Bouhuijs, Joey H., Olijhoek, Wouter, Bontjer, Ilja, Snitselaar, Jonne L., Caniels, Tom G., van der Linden, Cynthia A., Ravichandran, Rashmi, Villaudy, Julien, van der Velden, Yme U., Sliepen, Kwinten, van Gils, Marit J., Ward, Andrew B., King, Neil P., Heck, Albert J.R., and Sanders, Rogier W.

Published
2022
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26. De novo design of tunable, pH-driven conformational changes

Author

Boyken, Scott E, Benhaim, Mark A, Busch, Florian, Jia, Mengxuan, Bick, Matthew J, Choi, Heejun, Klima, Jason C, Chen, Zibo, Walkey, Carl, Mileant, Alexander, Sahasrabuddhe, Aniruddha, Wei, Kathy Y, Hodge, Edgar A, Byron, Sarah, Quijano-Rubio, Alfredo, Sankaran, Banumathi, King, Neil P, Lippincott-Schwartz, Jennifer, Wysocki, Vicki H, Lee, Kelly K, and Baker, David

Subjects
Biochemistry and Cell Biology, Chemical Sciences, Biological Sciences, Generic health relevance, Hydrogen-Ion Concentration, Protein Conformation, Protein Engineering, Protein Multimerization, Protein Stability, General Science & Technology
Abstract

The ability of naturally occurring proteins to change conformation in response to environmental changes is critical to biological function. Although there have been advances in the de novo design of stable proteins with a single, deep free-energy minimum, the design of conformational switches remains challenging. We present a general strategy to design pH-responsive protein conformational changes by precisely preorganizing histidine residues in buried hydrogen-bond networks. We design homotrimers and heterodimers that are stable above pH 6.5 but undergo cooperative, large-scale conformational changes when the pH is lowered and electrostatic and steric repulsion builds up as the network histidine residues become protonated. The transition pH and cooperativity can be controlled through the number of histidine-containing networks and the strength of the surrounding hydrophobic interactions. Upon disassembly, the designed proteins disrupt lipid membranes both in vitro and after being endocytosed in mammalian cells. Our results demonstrate that environmentally triggered conformational changes can now be programmed by de novo protein design.

Published
2019

28. Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

Author

Kraft, John C., Pham, Minh N., Shehata, Laila, Brinkkemper, Mitch, Boyoglu-Barnum, Seyhan, Sprouse, Kaitlin R., Walls, Alexandra C., Cheng, Suna, Murphy, Mike, Pettie, Deleah, Ahlrichs, Maggie, Sydeman, Claire, Johnson, Max, Blackstone, Alyssa, Ellis, Daniel, Ravichandran, Rashmi, Fiala, Brooke, Wrenn, Samuel, Miranda, Marcos, Sliepen, Kwinten, Brouwer, Philip J.M., Antanasijevic, Aleksandar, Veesler, David, Ward, Andrew B., Kanekiyo, Masaru, Pepper, Marion, Sanders, Rogier W., and King, Neil P.

Published
2022
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29. Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trial

Author

Song, Joon Young, Choi, Won Suk, Heo, Jung Yeon, Lee, Jin Soo, Jung, Dong Sik, Kim, Shin-Woo, Park, Kyung-Hwa, Eom, Joong Sik, Jeong, Su Jin, Lee, Jacob, Kwon, Ki Tae, Choi, Hee Jung, Sohn, Jang Wook, Kim, Young Keun, Noh, Ji Yun, Kim, Woo Joo, Roman, François, Ceregido, Maria Angeles, Solmi, Francesca, Philippot, Agathe, Walls, Alexandra C., Carter, Lauren, Veesler, David, King, Neil P., Kim, Hun, Ryu, Ji Hwa, Lee, Su Jeen, Park, Yong Wook, Park, Ho Keun, and Cheong, Hee Jin

Published
2022
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31. Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

Author

Malhi, Harman, Homad, Leah J., Wan, Yu-Hsin, Poudel, Bibhav, Fiala, Brooke, Borst, Andrew J., Wang, Jing Yang, Walkey, Carl, Price, Jason, Wall, Abigail, Singh, Suruchi, Moodie, Zoe, Carter, Lauren, Handa, Simran, Correnti, Colin E., Stoddard, Barry L., Veesler, David, Pancera, Marie, Olson, James, King, Neil P., and McGuire, Andrew T.

Published
2022
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33. Structure-based design of stabilized recombinant influenza neuraminidase tetramers

Author

Ellis, Daniel, Lederhofer, Julia, Acton, Oliver J., Tsybovsky, Yaroslav, Kephart, Sally, Yap, Christina, Gillespie, Rebecca A., Creanga, Adrian, Olshefsky, Audrey, Stephens, Tyler, Pettie, Deleah, Murphy, Michael, Sydeman, Claire, Ahlrichs, Maggie, Chan, Sidney, Borst, Andrew J., Park, Young-Jun, Lee, Kelly K., Graham, Barney S., Veesler, David, King, Neil P., and Kanekiyo, Masaru

Published
2022
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34. Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice

Author

Grigoryan, Lilit, Lee, Audrey, Walls, Alexandra C., Lai, Lilin, Franco, Benjamin, Arunachalam, Prabhu S., Feng, Yupeng, Luo, Wei, Vanderheiden, Abigail, Floyd, Katharine, Wrenn, Samuel, Pettie, Deleah, Miranda, Marcos C., Kepl, Elizabeth, Ravichandran, Rashmi, Sydeman, Claire, Brunette, Natalie, Murphy, Michael, Fiala, Brooke, Carter, Lauren, Coffman, Robert L., Novack, David, Kleanthous, Harry, O’Hagan, Derek T., van der Most, Robbert, McLellan, Jason S., Suthar, Mehul, Veesler, David, King, Neil P., and Pulendran, Bali

Published
2022
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35. Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate

Author

Sliepen, Kwinten, Radić, Laura, Capella-Pujol, Joan, Watanabe, Yasunori, Zon, Ian, Chumbe, Ana, Lee, Wen-Hsin, de Gast, Marlon, Koopsen, Jelle, Koekkoek, Sylvie, del Moral-Sánchez, Iván, Brouwer, Philip J. M., Ravichandran, Rashmi, Ozorowski, Gabriel, King, Neil P., Ward, Andrew B., van Gils, Marit J., Crispin, Max, Schinkel, Janke, and Sanders, Rogier W.

Published
2022
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36. Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance.

Author

Dadonaite, Bernadeta, Ahn, Jenny J., Ort, Jordan T., Yu, Jin, Furey, Colleen, Dosey, Annie, Hannon, William W., Vincent Baker, Amy L., Webby, Richard J., King, Neil P., Liu, Yan, Hensley, Scott E., Peacock, Thomas P., Moncla, Louise H., and Bloom, Jesse D.

Abstract

H5 influenza is considered a potential pandemic threat. Recently, H5 viruses belonging to clade 2.3.4.4b have caused large outbreaks in avian and multiple nonhuman mammalian species. Previous studies have identified molecular phenotypes of the viral hemagglutinin (HA) protein that contribute to pandemic potential in humans, including cell entry, receptor preference, HA stability, and reduced neutralization by polyclonal sera. However, prior experimental work has only measured how these phenotypes are affected by a handful of the >10,000 different possible amino-acid mutations to HA. Here, we use pseudovirus deep mutational scanning to measure how all mutations to a 2.3.4.4b H5 HA affect each phenotype. We identify mutations that allow HA to better bind α2-6-linked sialic acids and show that some viruses already carry mutations that stabilize HA. We also measure how all HA mutations affect neutralization by sera from mice and ferrets vaccinated against or infected with 2.3.4.4b H5 viruses. These antigenic maps enable rapid assessment of when new viral strains have acquired mutations that may create mismatches with candidate vaccine virus, and we show that a mutation present in some recent H5 HAs causes a large antigenic change. Overall, the systematic nature of deep mutational scanning combined with the safety of pseudoviruses enables comprehensive measurements of the phenotypic effects of mutations that can inform real-time interpretation of viral variation observed during surveillance of H5 influenza. H5 influenza is considered a potential pandemic threat. Using deep mutational scanning, this work reveals how the >10,000 different possible amino-acid mutations in hemagglutinin affect cell entry, receptor preference, protein stability and neutralization by antibodies, which can inform real-time interpretation of viral mutations observed during surveillance of H5 influenza. [ABSTRACT FROM AUTHOR]

Published
2024
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37. New on Audiobook: 3 Memorable Memoirs

Author

King, Neil, Jr., Hamilton, George, Rodgers, Mary, Green, Jesse, and Hughes, Frieda

Subjects
Audiobooks
Abstract

In March 2021, Pulitzer Prize-winning journalist Neil King Jr. set himself the task of walking from his home in Washington, D.C., to the island of Manhattan, a 330-mile journey he [...]

Published
2023

38. The Women’s wellness after cancer program: a multisite, single-blinded, randomised controlled trial protocol

Author

Anderson, Debra, Seib, Charrlotte, Tjondronegoro, Dian, Turner, Jane, Monterosso, Leanne, McGuire, Amanda, Porter-Steele, Janine, Song, Wei, Yates, Patsy, King, Neil, Young, Leonie, White, Kate, Lee, Kathryn, Hall, Sonj, Krishnasamy, Mei, Wells, Kathy, Balaam, Sarah, and McCarthy, Alexandra L

Subjects
Biomedical and Clinical Sciences, Health Services and Systems, Nursing, Public Health, Health Sciences, Behavioral and Social Science, Breast Cancer, Prevention, Clinical Research, Nutrition, Clinical Trials and Supportive Activities, Comparative Effectiveness Research, Tobacco Smoke and Health, Sleep Research, Cancer, Tobacco, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, Good Health and Well Being, Australia, Evidence-Based Nursing, Female, Health Education, Health Promotion, Health Surveys, Humans, Menopause, Neoplasms, New Zealand, Quality of Life, User-Computer Interface, Women's Health, Women, health-related quality of life, Menopausal symptoms, Modifiable lifestyle factors, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Epidemiology
Abstract

BackgroundDespite advances in cancer diagnosis and treatment have significantly improved survival rates, patients post-treatment-related health needs are often not adequately addressed by current health services. The aim of the Women's Wellness after Cancer Program (WWACP), which is a digitised multimodal lifestyle intervention, is to enhance health-related quality of life in women previously treated for blood, breast and gynaecological cancers.MethodsA single-blinded, multi-centre randomized controlled trial recruited a total of 351 women within 24 months of completion of chemotherapy (primary or adjuvant) and/or radiotherapy. Women were randomly assigned to either usual care or intervention using computer-generated permuted-block randomisation. The intervention comprises an evidence-based interactive iBook and journal, web interface, and virtual health consultations by an experienced cancer nurse trained in the delivery of the WWACP. The 12 week intervention focuses on evidence-based health education and health promotion after a cancer diagnosis. Components are drawn from the American Cancer Research Institute and the World Cancer Research Fund Guidelines (2010), incorporating promotion of physical activity, good diet, smoking cessation, reduction of alcohol intake, plus strategies for sleep and stress management. The program is based on Bandura's social cognitive theoretical framework. The primary outcome is health-related quality of life, as measured by the Functional Assessment of Cancer Therapy-General (FACT-G). Secondary outcomes are menopausal symptoms as assessed by Greene Climacteric Scale; physical activity elicited with the Physical Activity Questionnaire Short Form (IPAQ-SF); sleep measured by the Pittsburgh Sleep Quality Index; habitual dietary intake monitored with the Food Frequency Questionnaire (FFQ); alcohol intake and tobacco use measured by the Australian Health Survey and anthropometric measures including height, weight and waist-to-hip ratio. All participants were assessed with these measures at baseline (at the start of the intervention), 12 weeks (at completion of the intervention), and 24 weeks (to determine the level of sustained behaviour change). Further, a simultaneous cost-effectiveness evaluation will consider if the WWACP provides value for money and will be reported separately.DiscussionWomen treated for blood, breast and gynaecological cancers demonstrate increasingly good survival rates. However, they experience residual health problems that are potentially modifiable through behavioural lifestyle interventions such as the WWACP.Trial registrationThe protocol for this study was registered with the Australian and New Zealand Clinical Trials Registry, Trial ID: ACTRN12614000800628 , July 28, 2014.

Published
2017

39. Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance

Author

Dadonaite, Bernadeta, primary, Ahn, Jenny J, additional, Ort, Jordan T, additional, Yu, Jin, additional, Furey, Colleen, additional, Dosey, Annie, additional, Hannon, William W, additional, Baker, Amy Vincent, additional, Webby, Richard J, additional, King, Neil P, additional, Liu, Yan, additional, Hensley, Scott E, additional, Peacock, Thomas P, additional, Moncla, Louise H, additional, and Bloom, Jesse D, additional

Published
2024
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40. Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

Author

Chao, Cara W., primary, Sprouse, Kaitlin R., additional, Miranda, Marcos C., additional, Catanzaro, Nicholas J., additional, Hubbard, Miranda L., additional, Addetia, Amin, additional, Stewart, Cameron, additional, Brown, Jack T., additional, Dosey, Annie, additional, Valdez, Adian, additional, Ravichandran, Rashmi, additional, Hendricks, Grace G., additional, Ahlrichs, Maggie, additional, Dobbins, Craig, additional, Hand, Alexis, additional, Treichel, Catherine, additional, Willoughby, Isabelle, additional, Walls, Alexandra C., additional, McGuire, Andrew T., additional, Leaf, Elizabeth M., additional, Baric, Ralph S., additional, Schäfer, Alexandra, additional, Veesler, David, additional, and King, Neil P., additional

Published
2024
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42. Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

Author

Walls, Alexandra C., Miranda, Marcos C., Schäfer, Alexandra, Pham, Minh N., Greaney, Allison, Arunachalam, Prabhu S., Navarro, Mary-Jane, Tortorici, M. Alejandra, Rogers, Kenneth, O’Connor, Megan A., Shirreff, Lisa, Ferrell, Douglas E., Bowen, John, Brunette, Natalie, Kepl, Elizabeth, Zepeda, Samantha K., Starr, Tyler, Hsieh, Ching-Lin, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, Sydeman, Claire, Sprouse, Kaitlin R., Johnson, Max, Blackstone, Alyssa, Ravichandran, Rashmi, Ogohara, Cassandra, Carter, Lauren, Tilles, Sasha W., Rappuoli, Rino, Leist, Sarah R., Martinez, David R., Clark, Matthew, Tisch, Roland, O’Hagan, Derek T., Van Der Most, Robbert, Van Voorhis, Wesley C., Corti, Davide, McLellan, Jason S., Kleanthous, Harry, Sheahan, Timothy P., Smith, Kelly D., Fuller, Deborah H., Villinger, Francois, Bloom, Jesse, Pulendran, Bali, Baric, Ralph S., King, Neil P., and Veesler, David

Published
2021
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50. Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Author

Arunachalam, Prabhu S., Walls, Alexandra C., Golden, Nadia, Atyeo, Caroline, Fischinger, Stephanie, Li, Chunfeng, Aye, Pyone, Navarro, Mary Jane, Lai, Lilin, Edara, Venkata Viswanadh, Röltgen, Katharina, Rogers, Kenneth, Shirreff, Lisa, Ferrell, Douglas E., Wrenn, Samuel, Pettie, Deleah, Kraft, John C., Miranda, Marcos C., Kepl, Elizabeth, Sydeman, Claire, Brunette, Natalie, Murphy, Michael, Fiala, Brooke, Carter, Lauren, White, Alexander G., Trisal, Meera, Hsieh, Ching-Lin, Russell-Lodrigue, Kasi, Monjure, Christopher, Dufour, Jason, Spencer, Skye, Doyle-Meyers, Lara, Bohm, Rudolph P., Maness, Nicholas J., Roy, Chad, Plante, Jessica A., Plante, Kenneth S., Zhu, Alex, Gorman, Matthew J., Shin, Sally, Shen, Xiaoying, Fontenot, Jane, Gupta, Shakti, O’Hagan, Derek T., Van Der Most, Robbert, Rappuoli, Rino, Coffman, Robert L., Novack, David, McLellan, Jason S., Subramaniam, Shankar, Montefiori, David, Boyd, Scott D., Flynn, JoAnne L., Alter, Galit, Villinger, Francois, Kleanthous, Harry, Rappaport, Jay, Suthar, Mehul S., King, Neil P., Veesler, David, and Pulendran, Bali

Published
2021
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