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22 results on '"Kinderman, Priscilla"'

1. Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Author

Kurmasheva, Naziia, Said, Aida, Wong, Boaz, Kinderman, Priscilla, Han, Xiaoying, Rahimic, Anna H. F., Kress, Alena, Carter-Timofte, Madalina E., Holm, Emilia, van der Horst, Demi, Kollmann, Christoph F., Liu, Zhenlong, Wang, Chen, Hoang, Huy-Dung, Kovalenko, Elina, Chrysopoulou, Maria, Twayana, Krishna Sundar, Ottosen, Rasmus N., Svenningsen, Esben B., Begnini, Fabio, Kiib, Anders E., Kromm, Florian E. H., Weiss, Hauke J., Di Carlo, Daniele, Muscolini, Michela, Higgins, Maureen, van der Heijden, Mirte, Arulanandam, Rozanne, Bardoul, Angelina, Tong, Tong, Ozsvar, Attila, Hou, Wen-Hsien, Schack, Vivien R., Holm, Christian K., Zheng, Yunan, Ruzek, Melanie, Kalucka, Joanna, de la Vega, Laureano, Elgaher, Walid A. M., Korshoej, Anders R., Lin, Rongtuan, Hiscott, John, Poulsen, Thomas B., O’Neill, Luke A., Roy, Dominic G., Rinschen, Markus M., van Montfoort, Nadine, Diallo, Jean-Simon, Farin, Henner F., Alain, Tommy, and Olagnier, David

Published
2024
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2. Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Author

Kurmasheva, Naziia, Said, Aida, Wong, Boaz, Kinderman, Priscilla, Han, Xiaoying, Rahimic, Anna H. F., Kress, Alena, Carter-Timofte, Madalina E., Holm, Emilia, van der Horst, Demi, Kollmann, Christoph F., Liu, Zhenlong, Wang, Chen, Hoang, Huy-Dung, Kovalenko, Elina, Chrysopoulou, Maria, Twayana, Krishna Sundar, Ottosen, Rasmus N., Svenningsen, Esben B., Begnini, Fabio, Kiib, Anders E., Kromm, Florian E. H., Weiss, Hauke J., Di Carlo, Daniele, Muscolini, Michela, Higgins, Maureen, van der Heijden, Mirte, Arulanandam, Rozanne, Bardoul, Angelina, Tong, Tong, Ozsvar, Attila, Hou, Wen-Hsien, Schack, Vivien R., Holm, Christian K., Zheng, Yunan, Ruzek, Melanie, Kalucka, Joanna, de la Vega, Laureano, Elgaher, Walid A. M., Korshoej, Anders R., Lin, Rongtuan, Hiscott, John, Poulsen, Thomas B., O’Neill, Luke A., Roy, Dominic G., Rinschen, Markus M., van Montfoort, Nadine, Diallo, Jean-Simon, Farin, Henner F., Alain, Tommy, and Olagnier, David

Published
2024
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4. Figure S15 from Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell–Based Immunotherapies

Author

Groeneveldt, Christianne, primary, Kinderman, Priscilla, primary, Griffioen, Lisa, primary, Rensing, Olivia, primary, Labrie, Camilla, primary, van den Wollenberg, Diana J.M., primary, Hoeben, Rob C., primary, Coffey, Matt, primary, Loghmani, Houra, primary, Verdegaal, Els M.E., primary, Welters, Marij J.P., primary, van der Burg, Sjoerd H., primary, van Hall, Thorbald, primary, and van Montfoort, Nadine, primary

Published
2024
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5. Data from Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell–Based Immunotherapies

Author

Groeneveldt, Christianne, primary, Kinderman, Priscilla, primary, Griffioen, Lisa, primary, Rensing, Olivia, primary, Labrie, Camilla, primary, van den Wollenberg, Diana J.M., primary, Hoeben, Rob C., primary, Coffey, Matt, primary, Loghmani, Houra, primary, Verdegaal, Els M.E., primary, Welters, Marij J.P., primary, van der Burg, Sjoerd H., primary, van Hall, Thorbald, primary, and van Montfoort, Nadine, primary

Published
2024
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6. Supplementary Tables S1-S3 from Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell–Based Immunotherapies

Author

Groeneveldt, Christianne, primary, Kinderman, Priscilla, primary, Griffioen, Lisa, primary, Rensing, Olivia, primary, Labrie, Camilla, primary, van den Wollenberg, Diana J.M., primary, Hoeben, Rob C., primary, Coffey, Matt, primary, Loghmani, Houra, primary, Verdegaal, Els M.E., primary, Welters, Marij J.P., primary, van der Burg, Sjoerd H., primary, van Hall, Thorbald, primary, and van Montfoort, Nadine, primary

Published
2024
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7. Neutralizing Antibodies Impair the Oncolytic Efficacy of Reovirus but Permit Effective Combination with T cell–Based Immunotherapies

Author

Groeneveldt, Christianne, primary, Kinderman, Priscilla, additional, Griffioen, Lisa, additional, Rensing, Olivia, additional, Labrie, Camilla, additional, van den Wollenberg, Diana J.M., additional, Hoeben, Rob C., additional, Coffey, Matt, additional, Loghmani, Houra, additional, Verdegaal, Els M.E., additional, Welters, Marij J.P., additional, van der Burg, Sjoerd H., additional, van Hall, Thorbald, additional, and van Montfoort, Nadine, additional

Published
2024
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9. Preclinical evaluation of the gorilla‐derived HAdV‐B AdV‐lumc007 oncolytic adenovirus 'GoraVir' for the treatment of pancreatic ductal adenocarcinoma.

Author

Bots, Selas T. F., Harryvan, Tom J., Groeneveldt, Christianne, Kinderman, Priscilla, Kemp, Vera, van Montfoort, Nadine, and Hoeben, Rob C.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy which shows unparalleled therapeutic resistance due to its genetic and cellular heterogeneity, dense stromal tissue, and immune‐suppressive tumour microenvironment. Oncolytic virotherapy has emerged as a new treatment modality which uses tumour‐specific viruses to eliminate cancerous cells. Non‐human primate adenoviruses of the human adenovirus B (HAdV‐B) species have demonstrated considerable lytic potential in human cancer cells as well as limited preexisting neutralizing immunity in humans. Previously, we have generated a new oncolytic derivative of the gorilla‐derived HAdV‐B AdV‐lumc007 named 'GoraVir'. Here, we show that GoraVir displays oncolytic efficacy in pancreatic cancer cells and pancreatic‐cancer‐associated fibroblasts. Moreover, it retains its lytic potential in monoculture and co‐culture spheroids. In addition, we established the ubiquitously expressed complement receptor CD46 as the main entry receptor for GoraVir. Finally, a single intratumoural dose of GoraVir was shown to delay tumour growth in a BxPC‐3 xenograft model at 10 days post‐treatment. Collectively, these data demonstrate that the new gorilla‐derived oncolytic adenovirus is a potent oncolytic vector candidate that targets both pancreatic cancer cells and tumour‐adjacent stroma. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Data from Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy

Author

Groeneveldt, Christianne, primary, van Ginkel, Jurriaan Q., primary, Kinderman, Priscilla, primary, Sluijter, Marjolein, primary, Griffioen, Lisa, primary, Labrie, Camilla, primary, van den Wollenberg, Diana J.M., primary, Hoeben, Rob C., primary, van der Burg, Sjoerd H., primary, ten Dijke, Peter, primary, Hawinkels, Lukas J.A.C., primary, van Hall, Thorbald, primary, and van Montfoort, Nadine, primary

Published
2023
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11. Figure S5 from Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy

Author

Groeneveldt, Christianne, primary, van Ginkel, Jurriaan Q., primary, Kinderman, Priscilla, primary, Sluijter, Marjolein, primary, Griffioen, Lisa, primary, Labrie, Camilla, primary, van den Wollenberg, Diana J.M., primary, Hoeben, Rob C., primary, van der Burg, Sjoerd H., primary, ten Dijke, Peter, primary, Hawinkels, Lukas J.A.C., primary, van Hall, Thorbald, primary, and van Montfoort, Nadine, primary

Published
2023
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12. Table TS2 from Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy

Author

Groeneveldt, Christianne, primary, van Ginkel, Jurriaan Q., primary, Kinderman, Priscilla, primary, Sluijter, Marjolein, primary, Griffioen, Lisa, primary, Labrie, Camilla, primary, van den Wollenberg, Diana J.M., primary, Hoeben, Rob C., primary, van der Burg, Sjoerd H., primary, ten Dijke, Peter, primary, Hawinkels, Lukas J.A.C., primary, van Hall, Thorbald, primary, and van Montfoort, Nadine, primary

Published
2023
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13. Supplementary Methods SM1 from Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy

Author

Groeneveldt, Christianne, primary, van Ginkel, Jurriaan Q., primary, Kinderman, Priscilla, primary, Sluijter, Marjolein, primary, Griffioen, Lisa, primary, Labrie, Camilla, primary, van den Wollenberg, Diana J.M., primary, Hoeben, Rob C., primary, van der Burg, Sjoerd H., primary, ten Dijke, Peter, primary, Hawinkels, Lukas J.A.C., primary, van Hall, Thorbald, primary, and van Montfoort, Nadine, primary

Published
2023
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14. Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy

Author

Groeneveldt, Christianne, primary, van Ginkel, Jurriaan Q., additional, Kinderman, Priscilla, additional, Sluijter, Marjolein, additional, Griffioen, Lisa, additional, Labrie, Camilla, additional, van den Wollenberg, Diana J.M., additional, Hoeben, Rob C., additional, van der Burg, Sjoerd H., additional, ten Dijke, Peter, additional, Hawinkels, Lukas J.A.C., additional, van Hall, Thorbald, additional, and van Montfoort, Nadine, additional

Published
2023
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15. Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy

Author

Groeneveldt, Christianne, primary, Kinderman, Priscilla, additional, van Stigt Thans, Jordi J C, additional, Labrie, Camilla, additional, Griffioen, Lisa, additional, Sluijter, Marjolein, additional, van den Wollenberg, Diana J M, additional, Hoeben, Rob C, additional, den Haan, Joke M M, additional, van der Burg, Sjoerd H, additional, van Hall, Thorbald, additional, and van Montfoort, Nadine, additional

Published
2022
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16. 590 Pre-conditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy

Author

Groeneveldt, Christianne, primary, Kinderman, Priscilla, additional, Wollenberg, Diana JM van den, additional, Oever, Ruben L van den, additional, Middelburg, Jim, additional, Mustafa, Dana AM, additional, Hoeben, Rob, additional, Burg, Sjoerd van der, additional, Hall, Thorbald van, additional, and Montfoort, Nadine Van, additional

Published
2020
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17. Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy

Author

Groeneveldt, Christianne, primary, Kinderman, Priscilla, additional, van den Wollenberg, Diana J M, additional, van den Oever, Ruben L, additional, Middelburg, Jim, additional, Mustafa, Dana A M, additional, Hoeben, Rob C, additional, van der Burg, Sjoerd H, additional, van Hall, Thorbald, additional, and van Montfoort, Nadine, additional

Published
2020
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18. Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model

Author

Lau, Sai Ping, primary, van Montfoort, Nadine, additional, Kinderman, Priscilla, additional, Lukkes, Melanie, additional, Klaase, Larissa, additional, van Nimwegen, Menno, additional, van Gulijk, Mandy, additional, Dumas, Jasper, additional, Mustafa, Dana A M, additional, Lievense, Sanne L A, additional, Groeneveldt, Christianne, additional, Stadhouders, Ralph, additional, Li, Yunlei, additional, Stubbs, Andrew, additional, Marijt, Koen A, additional, Vroman, Heleen, additional, van der Burg, Sjoerd H, additional, Aerts, Joachim, additional, van Hall, Thorbald, additional, Dammeijer, Floris, additional, and van Eijck, Casper H J, additional

Published
2020
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19. Effect of targeting CD40 for DC vaccination in pancreatic adenocarcinoma.

Author

Lau, Sai Ping, primary, van Montfoort, Nadine, additional, Kinderman, Priscilla, additional, Lukkes, Melanie, additional, Dumas, Jasper, additional, van Nimwegen, Menno, additional, Mustafa, Dana, additional, Vroman, Heleen, additional, van Hall, Thorbald, additional, van der Burg, Sjoerd H., additional, Aerts, Joachim G.J.V., additional, Dammeijer, Floris, additional, and van Eijck, Casper H.J., additional

Published
2019
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20. Abstract B117: Allogeneic tumor-lysate loaded dendritic cells induce anti-tumor immunity and tumor responses in pre-clinical models of pancreatic adenocarcinoma: Towards clinical trials

Author

Lau, Sai Ping S., primary, Kinderman, Priscilla P., additional, Lukkes, Melanie M., additional, Dammeijer, Floris F., additional, Vroman, Heleen H., additional, Nimwegen, Menno M. van, additional, Hall, Thorbald T. van, additional, Burg, Sjoerd S.H. van der, additional, Aerts, Joachim J.G.J.V., additional, Montfoort, Nadine A.G. Pronk-van, additional, and Eijck, Casper C.H.J. van, additional

Published
2019
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22. Socs1-knockout in skin-resident CD4+T cells in a protracted contact-allergic reaction results in an autonomous skin inflammation with features of early-stage mycosis fungoides

Author

Luo, Yixin, Vermeer, Maarten H., de Haan, Sanne, Kinderman, Priscilla, de Gruijl, Frank R., van Hall, Thorbald, and Tensen, Cornelis P.

Abstract

Recent detailed genomic analysis of mycosis fungoides (MF) identified suppressor of cytokine signaling 1 (SOCS1), an inhibitor of JAK/STAT signaling, as one of the frequently deleted tumor suppressors in MF, and one-copy deletion of SOCS1 was confirmed in early-stage MF lesions. To better understand the functional role of SOCS1 in the genesis of MF, we used a genetically engineered mouse model emulating heterozygous SOCS1 loss in skin resident CD4+T cells. In these mice an experimentally induced contact-allergic reaction was maintained for 20 weeks. Ten weeks after discontinuing contact-allergic challenges, only the skin with locally one-copy deletion of Socs1 in CD4+T cells still showed high numbers of CD3+/CD4+Socs1 k.o. cells in the dermis (p ＜ 0.0001) with prevalent Stat3 activation (p ＜0.001). And in one out of 9 mice, this had progressed to far more dramatic increases, including the thickened epidermis, and with an explosive growth of Socs1 k.o. T cells in circulation; indicative of cutaneous lymphoma. Hence, we show that Socs1 mono-allelic loss in CD4+T cells locally in protractedly inflamed skin results in autonomous skin inflammation with features of early-stage MF.

Published
2023
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