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2. 耳鼻咽喉科診療所を初診した新型コロナウイルス感染症 (COVID-19) の臨床像 : 日本臨床耳鼻咽喉科医会アンケート調査結果

Author

Kimura, Yurika, primary, Nogami, Kenichiro, additional, Watanabe, Kazuo, additional, Yoshimura, Tadashi, additional, Asai, Hideyo, additional, Fujioka, Osamu, additional, Kawasaki, Yoshiaki, additional, Igarashi, Mitsuru, additional, Inamura, Naoki, additional, Kawashima, Kayoko, additional, Nishino, Hiroshi, additional, and Fukuyo, Kazumasa, additional

Published
2023
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4. COVID-19 Omicron variant-induced laryngitis.

Author

Kimura, Yurika, Hirabayashi, Eiko, Yano, Mai, Fujitani, Satoru, and Shioiri, Sadaaki

Subjects
*SARS-CoV-2 Omicron variant, *DEGLUTITION disorders, *COVID-19, *LARYNGITIS, *COVID-19 pandemic, *OXYGEN in the blood
Abstract

The COVID-19 omicron variant has a low affinity for the lower respiratory tract. However, upper respiratory tract symptoms, such as nasal discharge and sore throat, characterize the infection with this variant. Therefore, in laryngeal stenosis, disease severity assessment through blood oxygen saturation has not been useful. We report the case of "omicron laryngitis" in a 59-year-old male who visited the ear, nose, and throat (ENT) clinic with complaints of a sore throat and difficulty in swallowing saliva that persisted for a day. Laryngoscopy revealed severe swelling of the transglottic region and exudates on the larynx. He was then diagnosed with COVID-19 and subjected to emergency tracheostomy for airway management. Until the emergence of the omicron variant, COVID-19 showed mainly lower airway and mild upper airway inflammatory features. However, upper airway stenosis should be suspected in cases presenting with "muffled speech," "dysphagia," "severe pain on swallowing," and "inspiratory dyspnea or stridor." Therefore, laryngeal and pharyngeal evaluation using a flexible laryngoscope under appropriate infection control measures is necessary, considering the possibility of progression to fatal laryngeal stenosis, as noted in this case. [ABSTRACT FROM AUTHOR]

Published
2023
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7. COVID-19 findings revealed via otolaryngological examination: Findings of a Japan Otorhinolaryngologist Association questionnaire

Author

Kimura, Yurika, primary, Nogami, Kenichiro, additional, Watanabe, Kazuo, additional, Yoshimura, Tadashi, additional, Asai, Hideyo, additional, Fujioka, Osamu, additional, Kawasaki, Yoshiaki, additional, Igarashi, Mitsuru, additional, Inamura, Naoki, additional, Kawashima, Kayoko, additional, Nishino, Hiroshi, additional, and Fukuyo, Kazumasa, additional

Published
2021
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8. Management of tracheostomy in COVID-19 patients: The Japanese experience

Author

Yokokawa, Taizo, primary, Ariizumi, Yosuke, additional, Hiramatsu, Mariko, additional, Kato, Yujin, additional, Endo, Kazuhira, additional, Obata, Kazufumi, additional, Kawashima, Kayoko, additional, Sakata, Toshifumi, additional, Hirano, Shigeru, additional, Nakashima, Torahiko, additional, Sekine, Tatsurou, additional, Kiyuna, Asanori, additional, Uemura, Saeko, additional, Okubo, Keisuke, additional, Sugimoto, Taro, additional, Tateya, Ichiro, additional, Fujimoto, Yasushi, additional, Horii, Arata, additional, Kimura, Yurika, additional, Hyodo, Masamitsu, additional, and Homma, Akihiro, additional

Published
2021
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9. Management of tracheostomy in COVID-19 patients : The Japanese experience

Author

Yokokawa, Taizo, Ariizumi, Yosuke, Hiramatsu, Mariko, Kato, Yujin, Endo, Kazuhira, Obata, Kazufumi, Kawashima, Kayoko, Sakata, Toshifumi, Hirano, Shigeru, Nakashima, Torahiko, Sekine, Tatsurou, Kiyuna, Asanori, Uemura, Saeko, Okubo, Keisuke, Sugimoto, Taro, Tateya, Ichiro, Fujimoto, Yasushi, Horii, Arata, Kimura, Yurika, Hyodo, Masamitsu, 1000030312359, Homma, Akihiro, Yokokawa, Taizo, Ariizumi, Yosuke, Hiramatsu, Mariko, Kato, Yujin, Endo, Kazuhira, Obata, Kazufumi, Kawashima, Kayoko, Sakata, Toshifumi, Hirano, Shigeru, Nakashima, Torahiko, Sekine, Tatsurou, Kiyuna, Asanori, Uemura, Saeko, Okubo, Keisuke, Sugimoto, Taro, Tateya, Ichiro, Fujimoto, Yasushi, Horii, Arata, Kimura, Yurika, Hyodo, Masamitsu, 1000030312359, and Homma, Akihiro

Abstract

Objective: Involvement in the tracheostomy procedure for COVID-19 patients can lead to a feeling of fear in medical staff. To address concerns over infection, we gathered and analyzed experiences with tracheostomy in the COVID-19 patient population from all over Japan. Methods: The data for health-care workers involved in tracheostomies for COVID-19-infected patients were gathered from academic medical centers or their affiliated hospitals from all over Japan. Results: Tracheostomies have been performed in 35 COVID-19 patients with a total of 91 surgeons, 49 anesthesiologists, and 49 surgical staff members involved. Twenty-eight (80%) patients underwent surgery more than 22 days after the development of COVID-19-related symptoms (11: 22-28 days and 17: >= 29 days). Thirty (85.7%) patients underwent surgery >= 15 days after intubation (14: 15-21 days, 6: 22-28 days, and 10: >= 29 days). Among the total of 189 health-care workers involved in the tracheostomy procedures, 25 used a powered air-purifying respirator (PAPR) and 164 used a N95 mask and eye protection. As a result, no transmission to staff occurred during the 2 weeks of follow-up after surgery. Conclusion: No one involved in tracheostomy procedures were found to have been infected with COVID-19 in this Japanese study. The reason is thought to be that the timing of the surgery was quite late after the infections, and the surgery was performed using appropriate PPE and surgical procedure. The indications for and timing of tracheostomy for severe COVID-19 patients should be decided through multidisciplinary discussion. (c) 2021 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.

Published
2021

10. Questionnaire survey on nurses and speech therapists regarding dysphagia rehabilitation in Japan

Author

Kato, Kengo, primary, Ikeda, Ryoukichi, additional, Suzuki, Jun, additional, Hirano-Kawamoto, Ai, additional, Kamakura, Yayoi, additional, Fujiu-Kurachi, Masako, additional, Hyodo, Masamitsu, additional, Izumi, Shin-Ichi, additional, Koyama, Shigeto, additional, Sasaki, Keiichi, additional, Nakajima, Junko, additional, Karaho, Takahiro, additional, Kimura, Yurika, additional, Kumai, Yoshihiko, additional, Fujimoto, Yasushi, additional, Nito, Takaharu, additional, Oku, Yoshitaka, additional, Kurosawa, Hajime, additional, Kuriyama, Shinichi, additional, and Katori, Yukio, additional

Published
2021
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27. Improving the Quality of Life of Patients With Severe Dysphagia by Surgically Closing the Larynx.

Author

Kimura, Yurika, Kishimoto, Seiji, Sumi, Takuro, Uchiyama, Mio, Ohno, Keiko, Kobayashi, Hitome, and Kano, Makoto

Subjects
*CARTILAGE, *LARYNGEAL surgery, *AFFECT (Psychology), *CAREGIVERS, *DEGLUTITION disorders, *INFLAMMATION, *QUALITY of life, *SATISFACTION, *SURGICAL complications, *ACTIVITIES of daily living, *TREATMENT effectiveness, *NUTRITIONAL status, *BARTHEL Index, *SURGERY
Abstract

Objectives: The aim of this study was to elucidate the utility of the Kano method with surgical closure of the larynx by cricoid cartilage removal in improving quality of life in patients with severe dysphagia and their caregivers. Methods: Nine patients with severe dysphagia who underwent the Kano method were evaluated for oral intake and activities of daily living using the functional oral intake scale and the Barthel index, respectively, as indices of quality of life. Additionally, nutritional status, inflammation, and postoperative complications were assessed. Furthermore, 7 family caregivers were queried regarding frequency of sputum suction, mood of family caregivers, and postoperative satisfaction. Results: Functional oral intake scale and Barthel index scores as well as inflammation improved significantly after surgery (P < .05). There were no severe complications or other complications requiring surgical intervention. The frequency of sputum suction was reduced postoperatively (P < .05). The mood of family caregivers was significantly improved and satisfaction level was high postoperatively. Conclusions: Surgical closure of the larynx is an appropriate choice for patients with irreversible severe dysphagia and impaired articulation or vocal function because quality of life is improved for both patients and family caregivers and the satisfaction of family caregivers is sufficient. [ABSTRACT FROM AUTHOR]

Published
2019
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28. Successful treatment of eosinophilic otitis media associated with severe bronchial asthma with an anti-IL-5 monoclonal antibody, mepolizumab.

Author

Suzaki, Isao, Kimura, Yurika, Tanaka, Akihiko, Hirano, Kojiro, Ishibashi, Atsushi, Mizuyoshi, Tomomi, Ando, Izumi, Kitajima, Tatsuya, Watanabe, So, Hinohira, Yasuyuki, Kobayashi, Hitome, and Hinonira, Yasuyuki

Subjects
*OTITIS media, *ASTHMA, *OTITIS media with effusion, *MONOCLONAL antibodies, *ASTHMATICS, *EARLY diagnosis, *THERAPEUTIC use of monoclonal antibodies, *DRUG therapy for asthma, *EOSINOPHILIA, *HEARING disorders, *TREATMENT effectiveness, *SEVERITY of illness index, *DISEASE complications
Abstract

Eosinophilic otitis media (EOM), which is characterized by the accumulation of eosinophils in middle ear effusion and the middle ear mucosa, is a refractory type of otitis media that is often associated with asthma. Although an early diagnosis and appropriate treatment are necessary to prevent the progression of hearing loss in patients with EOM, there are currently no well-established treatments for this condition. We treated a 60-year-old male patient with asthma and EOM. The patient's asthma was poorly controlled, despite the use of high-dose inhaled corticosteroids, long-acting beta-agonist treatment, and the regular use of systemic corticosteroids. Mepolizumab, an anti-IL-5 monoclonal antibody, was started to treat the patient's refractory asthma. At 4 months after the initiation of mepolizumab treatment, the patient's asthma, hearing, and middle ear effusion improved. The present case suggests that mepolizumab therapy can control EOM and asthma. [ABSTRACT FROM AUTHOR]

Published
2019
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36. Eight Cases of Surgical Glottic Closure for Severe Aspiration

Author

Egawa, Shunya, primary, Ikeda, Kenichiro, additional, Ikenoya, Yoichi, additional, Kushihashi, Yukiomi, additional, Takahashi, Go, additional, Kobayashi, Sei, additional, Terasaki, Masako, additional, Kimura, Yurika, additional, Kobayashi, Hitome, additional, and Shimane, Toshikazu, additional

Published
2016
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38. A 3-Dimensional Model of the Human Round Window Membrane

Author

Moon, Sung K., Kawauchi, Hideyuki, Oh, Seung-Ha, Nomura, Yasuya, Tanaka, Toru, Kobayashi, Hitome, Kimura, Yurika, Soejima, Yurie, and Sawabe, Motoji

Abstract

Objectives: The round window membrane (RWM) is small in size, making it difficult to clarify its shape and structure. The authors examined a 40x magnified 3-dimensional model of the human RWM to clarify its morphologic aspects and characteristics.Methods: An RWM specimen was obtained from an archival, formalin-fixed, decalcified, left temporal bone of an 84-year-old female cadaver. The data obtained by laser scanning microscopy were input into a 3-dimensional printer. After a model of the RWM was created, the following features were examined: striae on the surfaces, curvatures, thickness, and areas. Cross sections of the original specimen were made for histological observations.Results: The contour of this RWM model was approximately elliptic, with a saddle shape. When illuminated from the scala tympani side, the surface facing the fossula exhibited dark anterior and clear posterior portions. A borderline appeared where the 2 portions were bound along the short axis of the ellipse. This borderline was identified as the line of inflection. Collagen fibers were shown to run parallel to the borderline in the posterior portion but were fanned out in the anterior portion.Conclusions: The magnified 3-dimensional model clarified gross anatomy and characteristics of the RWM. It is good teaching material for small tissues, such as the RWM.

Published
2019
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42. Increased number of IgG4-positive plasma cells in chronic rhinosinusitis.

Author

Ohno, Keiko, Kimura, Yurika, Matsuda, Yoko, Takahashi, Masatoki, Honjyou, Motomu, Arai, Tomio, and Tsutsumi, Takeshi

Subjects
*HYPERPLASIA, *BLOOD plasma, *CELLS, *FISHER exact test, *IMMUNOGLOBULINS, *IMMUNOHISTOCHEMISTRY, *MEDICAL records, *MUCOUS membranes, *NOSE, *SINUSITIS, *STAINS & staining (Microscopy), *FIBROSIS, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *MANN Whitney U Test
Abstract

Conclusion:High levels of IgG4-positive plasma cells were observed in tissue samples from ∼30% of patients with chronic rhinosinusitis who satisfied the comprehensive diagnostic criteria for IgG4-related disease. Detection of increased numbers of IgG4-positive plasma cells in the nasal cavity or paranasal sinuses might not be sufficient to make a diagnosis of IgG4-related rhinosinusitis, and a comprehensive evaluation is required. Objectives:This study aimed to clarify the clinicopathological characteristics of IgG4-positive plasma cells in patients with chronic rhinosinusitis. Method:This study examined nasal mucosal specimens from 35 patients and assigned them to high-IgG4 and low-IgG4 groups based on infiltration of IgG4-positive plasma cells. It compared the pathological characteristics of the two groups, including the presence of fibrosis, phlebitis, hyperplasia of the nasal glands and infiltration of inflammatory cells. Results:No cases of chronic rhinosinusitis showed storiform fibrosis or obliterative phlebitis. The mean number of IgG4-positive plasma cells in samples from all patients was 29.8 ± 40.3/high-power field. Eleven of the 35 cases (31.4%) were classified as high-IgG4. Hyperplasia of the nasal glands was observed significantly more frequently in the high-IgG4 group than in the low-IgG4 group (p = .03). [ABSTRACT FROM PUBLISHER]

Published
2017
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