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1. Designation Products: Boron Neutron Capture Therapy for Head and Neck Carcinoma

Author

Kanno, Hitoshi, primary, Nagata, Hironori, additional, Ishiguro, Akihiro, additional, Tsuzuranuki, Satoshi, additional, Nakano, Shintaro, additional, Nonaka, Takahiro, additional, Kiyohara, Koushin, additional, Kimura, Toshinari, additional, Sugawara, Akihiko, additional, Okazaki, Yuzuru, additional, Takae, Shinichi, additional, Nakabayashi, Tetsuo, additional, Arai, Hiroyuki, additional, and Suzuki, Hiroshi, additional

Published
2021
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4. Abstracts of selected papers presented at the 79th general meeting of the Japanese Society of Gastroenterology March 29–31, 1993, Kyoto, Japan

Author

Uehara, Akira, Namiki, Masayoshi, Yoneda, Masashi, Taché, Yvette, Suzuki, Hidekazu, Miura, Soichiro, Otaka, Michiro, Masamune, Osamu, Fukudo, Shin, Nomura, Taisuke, Abe, R., Shimosegawa, T., Nakamura, Keiya, Aoike, Akira, Yamaguchi, Hiroya, Kimura, Toshinari, Nakamura, Toshikazu, Matsumoto, Kunio, Tomiya, Tomoaki, Fujiwara, Kenji, Mori, Kenji, Yasunaga, Mitsuru, Yasuda, Hiroshi, Kojima, Itaru, Ohnishi, Hiroo, Nagaki, Masahito, Koide, Norio, Tsuji, Takao, Nagano, Kouichi, Kawano, Sunao, Kihira, Ken, Satoh, Kiichi, Sakaki, Nobuhiro, Yamada, Yoshiya, Karita, Mikio, Yoshimatsu, Tateo, Nakashima, Takatoshi, Aoyama, Nobuo, Fukuda, Yoshihiro, Tamura, Kazutami, Sugiyama, T., Yabana, T., Lin, Jaw-Town, Sueoka, Nobuo, Iwakiri, Katsuhiko, Watanabe, Sumio, Sato, Nobuhiro, Yamasaki, Kazuaki, Okazaki, Kazuichi, Nishino, Hirokazu, Muroi, Tadaki, Matsuda, Yoshiro, Tsutsumi, Mikihiro, Oshita, Masahide, Takei, Yoshiyuki, Kumashiro, Ryukichi, Tanikawa, Kyuichi, Nagao, Yasuyuki, Okanoue, Takeshi, Tsukada, Nobuhiro, Oda, Masaya, Ishii, Motoyasu, Yamamoto, Takeshi, Komatsu, Masafumi, Nakajima, Ko, Sakisaka, Shotaro, Tanikawa, Kyuichi, Itoh, Fumio, Imai, Kohzoh, Shintani, Yutaka, Bamba, Tadao, Saito, Eiichi, Ogihara, Akifumi, Bamba, Tadao, Sasaki, Masaya, Fujimoto, Kazuma, Iwakiri, Ryuichi, Hosomi, Motonobu, Takada, Fumio, Obayashi, Makoto, Kitano, Atushi, Nagoshi, Sumiko, Fujiwara, Kenji, Tanaka, T., Monna, T., Matsuzaki, Yutaka, Sugimoto, Hiroyuki, Machishi, Hideki, Mizumoto, Ryuji, Matsuda, Kazuya, Uchida, Yoshihito, Okano, H., Aoyama, N., Yamada, Masahiko, Hongo, Michio, Shibata, Yoshihisa, Miyachi, Masahiko, Nimura, Yuji, Neya, Toshiaki, Mizutani, Masatoshi, Inoue, Jun, Nakamura, Masahiko, Aoyama, Nobuo, Futami, Sachiko, Funakoshi, K., Sugimura, K., Iwao, Yasushi, Hibi, Toshifumi, Kusugami, Kazuo, Morise, Kimitomo, Kimura, Mitsuo, Hiwatashi, Nobuo, Kanzaki, Shinichiro, Makiyama, Kazuya, Yamamura, Makoto, Satomi, Masamichi, Harada, Hirofumi, Shimada, Hiroshi, Yoshida, Norimasa, Yoshikawa, Toshikazu, Hiraishi, Hideyuki, Harada, Takashi, Suzuki, Masayuki, Miura, Soichiro, Masuda, E., Kawano, S., Matsui, H., Fukutomi, H., Oshitani, Nobuhide, Kitano, Atsuo, Suematsu, Makoto, Suzuki, Hidekazu, Togashi, Hitoshi, Shinzawa, Haruhide, Murakami, Hiroya, Takagi, Hiroshi, Kasugai, Hiroshi, Tatsuta, Masaharu, Urabe, Takeshi, Unoura, Masashi, Yamanaka, Naoki, Okamoto, Eizo, Takayama, Tadatoshi, Yamasaki, Susumu, Kita, Kazuhiko, Ebara, Masaaki, Majima, Yasuo, Tanikawa, Kyuichi, Matsui, Osamu, Demachi, Hiroshi, Seki, Toshihito, Inoue, Kyoichi, Ohnishi, Kunihiko, Ito, Susumu, Kaneko, Akira, Hayashi, Norio, Yoneyama, Keiichiro, Mitamura, Keiji, Higashi, Katsuyoshi, Hoshino, Makoto, Ogasawara, Hisataka, Sirahama, Keigo, Hashimoto, Naoki, Yamada, Haruki, Shiratori, Yasushi, Okano, Ken’ichi, Minemura, Masami, Watanabe, Akiharu, Masaki, Tsutomu, Tokuda, Masaaki, Kawano, Tatsuyuki, Endo, Mitsuo, Kouzu, Teruo, Sakaguchi, Humiaki, Hanyu, Nobuyoshi, Aoki, Teruaki, Shimamoto, Chikao, Hirata, Ichiro, Sasajima, Koji, Takubo, Kaiyo, Kawaura, Yukimitsu, Kawakami, Kazuyuki, Hayashi, Hiroto, Suzuki, Takashi, Watanabe, Kazuo, Watanabe, Hidenobu, Hino, Naoki, Higashi, Toshihiro, Shiro, Tomohiro, Inoue, Kyoichi, Hongo, Yasushi, Tada, Hideki, Saitoh, K., Akiyama, Y., Mitsufuji, Shoji, Tsuchihashi, Yasunari, Nishimura, K., Hosokawa, Y., Wada, Ryo, Suda, Kouichi, Mafune, Ken-ichi, Idezuki, Yasuo, Mizuno, Motowo, Tsuji, Takao, Watanabe, Mamoru, Hibi, Toshifumi, Matsumoto, Takayuki, Kobayashi, Kenzo, Morise, Kimitomo, Yamaguchi, Takeo, Watanabe, T., Kubota, Y., Andoh, Akira, Fujiyama, Yoshihide, Tanaka, Kanji, Hioki, Koshirou, Hinoda, Yuji, Imai, Kohzoh, and Ohtani, Haruo

Published
1993
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5. Abstracts of selected papers presented at the 34th annual meeting of the japanese society of gastroenterology

Author

Nakamuta, Koji, Makiyama, Kazuya, Satomi, Masamichi, Yamamura, Makoto, Oshitani, Nobuhide, Kitano, Atsuo, Hiwatashi, Nobuo, Ito, Kaoru, Iwashita, Etsuro, Koyama, Hiroshi, Sugita, Akira, Fukushima, Tsuneo, Suzuki, K., Sawada, T., Ikei, Satoshi, Ogawa, Michio, Fururawa, Masayuki, Kimura, Toshinari, Koiwai, Toshihiko, Oguchi, Hisao, Sobajima, Hiroshi, Hayakawa, Tetsuo, Yamamoto, Masahiro, Saitoh, Yoichi, Kyogoku, T., Manabe, T., Kataoka, Keisho, Tachibana, Issei, Takikawa, Hajime, Yamanaka, Masami, Ishii, Motoyasu, Miura, Masahito, Ohta, Masahuru, Okanoue, Takeshi, Watanabe, Norihito, Oda, Masaya, Kakisaka, Akitoshi, Mito, Michio, Fukumoto, Yohei, Yasunaga, Mitsuru, Sakisaka, Shotaro, Tanikawa, Kyuichi, Sezai, Shuichi, Hirano, Masanori, Nishida, Toshio, Atsumi, M., Furukawa, Hiroshi, Ariyama, Joe, Shibata, Tokimune, Ebara, Masaaki, Arii, Shigeki, Chayama, Kazuaki, Nishiguchi, Shuhei, Hayashi, Norio, Akahane, Yoshihiro, Takase, Shujiro, Yasuda, Kiyomi, Karino, Yoshiyasu, Arita, Masahide, Miyahara, Toru, Tsukamoto, Yoshihisa, Nakamura, Takashi, Akimoto, Hiroshi, Ishihara, Fumitake, Tazuma, Susumu, Yamamoto, Fumio, Tsuyuguchi, Toshio, Nagakawa, Takukazu, and Tokumura, Hiromi

Published
1993
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7. Abstracts of Selected Papers Presented at the 76th General Meeting of the Japanese Society of Gastroenterology

Author

Watanabe, Yasuyuki, Nakanishi, Toshi, Mori, Yoshio, Oto, Masao, Onji, Morikazu, Ohta, Yasuyuki, Kuroki, Tetsuo, Yamamoto, Sukeo, Iwasaki, Yoshiaki, Tsuji, Takao, Ikeda, Yusei, Toda, Gotaro, Saitoh, T., Asakura, H., Onishi, Saburo, Iwasaki, Shinji, Oda, M., Azuma, T., Ikeda, Takaaki, Hasumura, Yasushi, Usui, K., Ishii, H., Nakano, Hitoshi, Tanikawa, Kyuichi, Inoue, Kyoichi, Higuchi, Kiyohiro, Hasumura, Satoshi, Nagamori, Scishi, Okanoue, Takeshi, Morimoto, Michio, Koide, Norio, Tsuji, Takao, Hayashi, Norio, Sato, Nobuhiro, Ono, Shigeki, Moriyasu, Fuminori, Miyazaki, Kohji, Hisatsugu, Takeharu, Kawamura, Yasuhito, Nakanuma, Yasuni, Tarao, Kazuo, Shimizu, Akio, Nishida, Jiro, Oda, Masaya, Okabayashi, Yoshinori, Otsuki, Makoto, Hosotani, Ryo, Tobe, Takayoshi, Sumii, Kimura, Toshinari, Mutoh, Hiroyuki, Terano, Akira, Terashima, H., Yabana, T., Yakabe, Koji, Nakamura, Takashi, Yamada, Tadataka, Chiba, T., Fujita, T., Ikeda, Yoshitake, Kitajima, Masaki, Nakajo, Shinobu, Minemori, Kiyoharu, Nakanishi, Takashi, and Okuno, Masaru

Published
1992
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8. Abstracts of selected papers presented at the 76th General Meeting of the Japanese Society of Gastroenterology March 29–31, 1990, Tokyo, Japan

Author

Kumada, Hiromitsu, Arase, Yasuji, Akahane, Yoshihito, Miyazaki, Yoshiki, Tanaka, E., Sodeyama, T., Koga, Michiaki, Yano, Michitami, Yamada, Gotaro, Tsuji, Takao, Hayashi, Norio, Kamada, Takenobu, Omata, Masao, Yokosuka, Osamu, Hino, Kunihiko, Kurai, Kiyohiko, Nakamura, Takashi, Tamura, Yumiko, Saigenji, Katsunori, Yamagata, Susumu, Fukutomi, Hisayuki, Saeki, Susumu, Nakashima, Takatoshi, Kawano, Sunao, Sato, Nobuhiro, Nakamura, Masahiko, Oda, Masaya, Kitajima, M., Ikeda, Y., Watanabe, Yozo, Tsumura, Hidenori, Aoki, Teruaki, Kashiwagi, Hideyuki, Hayakawa, Tetsuo, Shibata, Tokimune, Isaji, Shuji, Mizumoto, Ryuji, Kimura, Toshinari, Furukawa, Masayuki, Takeyama, Yoshifumi, Saitoh, Yoichi, Atomi, Y., Yamagishi, T., Nonaka, Atsushi, Manabe, Tadao, Kyogoku, Takahisa, Tamura, Koichiro, Tobe, Takayoshi, Ishibashi, Tadaaki, Ochi, Koji, Yoshioka, Utako, Inoue, Hisayuki, Mizukami, Yuji, Hirabayashi, Yasushi, Noda, Aiji, and Takayama, Tetsuo

Published
1991
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11. A case of pancreatic arteriovenous malformation associated with acute pancreatitis

Author

TAKAOKA, Takehiro, primary, KATSUHARA, Shunsuke, additional, UCHIMURA, Kohtaro, additional, KUBO, Hiroaki, additional, GOTO, Tatsuro, additional, OGAMI, Yoshimitsu, additional, OKADA, Yasuyo, additional, KIMURA, Toshinari, additional, MORITA, Koichiro, additional, USHIJIMA, Yasuhiro, additional, NAKAYAMA, Hiromichi, additional, OTSUKA, Takao, additional, NAKAMURA, Masafumi, additional, MOCHIDOME, Naoki, additional, OISHI, Yoshihiro, additional, ODA, Yoshinao, additional, IGARASHI, Hisato, additional, and ITO, Tetsuhide, additional

Published
2017
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16. Proceedings of the 64th annual meeting from May 22 to 24, 1978—Sapporo, Japan

Author

Okayama, Toshikata, Koizumi, Fumiaki, Watanabe, Hideo, Kaneko, Toshio, Oka, Hiroshi, Kaneto, Akio, Yanaihara, Noboru, Nakaya, Scishi, Itoh, Zen, Yamaguchi, Ken, Adachi, Isamu, Zeze, Fujio, Abe, Kaoru, Kameya, Toru, Arai, Saburo, Yanaihara, Noboru, Yanaihara, Noboru, Sato, Haruko, Yanaihara, Chizuko, Sugiyama, Mitsugi, Watanabe, Yozo, Matsumura, Mitsuhiro, Kishi, Sciichiro, Mori, Hiroyoshi, Akiroshi, Hiroto, Shima, Kenji, Tanaka, Ryoichi, Matsuyama, Tatsuo, Morishita, Tetsuo, Tsuchiya, Masaharu, Arakawa, Yasuyuki, Nishikawa, Hiroshi, Kawase, Harumichi, Kitahara, Toshihisa, Fujisawa, Kiyoshi, Kameda, Haruo, Ando, Takashi, Suematsu, Toshihiko, Matumura, T., Sato, N., Kamada, T., Abe, H., Hayakawa, Tetsuo, Takebe, Takaaki, Ohyama, Kozo, Kihara, Akira, Wakasugi, Hideyuki, Kimura, Toshinari, Funakoshi, Akihiro, Aso, Nobunori, Matsumoto, Masa-Hiro, Sakimoto, Tetsuro, Ibayashi, Hiroshi, Matsuura, Akira, and Kasugai, Tatsuzo

Published
1979
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19. Proceedings of the 71st General Meeting Sapporo, Japan, May 22–24, 1985

Author

Suyama, Masafumi, Ariyama, Jo, Higashi, Shunsaku, Mizumoto, Ryuji, Sato, Morio, Yamada, Ryusaku, Ohsaki, Yukio, Shimizu, Tatsuo, Takenaka, Kenji, Kanematsu, Takashi, Yumoto, Yasuhiro, Jinno, Kenji, Izawa, Kunihide, Tsuchiya, Ryoichi, Ohto, Masao, Sugiura, Nobuyuki, Kinoshita, Hiroaki, Sakai, Katsuji, Shingai, Yasushi, Kado, Yuji, Yamanaka, Naoki, Okamoto, Eizo, Toyosaka, Akihiko, Yabuki, Kohei, Abe, Kazuo, Ohshiba, Saburo, Hata, Yoshinobu, Nishi, Shinzo, Ishii, Nobuko, Nagataki, Shigenobu, Shimano, Takashi, Mori, Takesada, Ohkura, Hisanao, Hirohashi, Setsuo, Sawabu, Norio, Toya, Daishu, Sawabu, Norio, Toya, Daishu, Watanabe, Masahiko, Hirohashi, Setsuo, Okumura, Shuichi, Saitoh, Yoichi, Nakamura, Noriaki, Hirota, Masaki, Kanoh, Makoto, Kaneda, Haruo, Adachi, Kenji, Koyama, Shin, Hatakeyama, Katsuyoshi, Fukushima, Tsuneo, Tsuchiya, Shuji, Iwama, Takeo, Mishima, Yoshiro, Tsuburaya, T., Kushida, T., Uchino, J., Yamasaki, Susumu, Hasegawa, Hiroshi, Manabe, Tadao, Suzuki, Takashi, Yonemura, Yutaka, Sekoguchi, Tsutomu, Mizumoto, Ryuji, Ebata, Hidetaka, Hayashi, Hirokazu, Arakawa, Yasuyuki, Yasuda, Morihide, Inoue, Kazutomo, Hosotani, Ryo, Funakoshi, Akihiro, Nakano, Itsuro, Yamamura, T., Takahashi, T., Miyata, Masahiro, Nakao, Kazuyasu, Imamura, Mikio, Sato, Toshio, Kishimoto, Shinya, Kajiyama, Goro, Noda, Aiji, Hayakawa, Tetsuo, Nagata, Atsuo, Homma, Tatsuji, Miyake, Hirofumi, Harada, Hideo, Kimura, Toshinari, Sumi, Toshihiko, Miyasaka, Kyoko, Kitani, Kenichi, Yamauchi, H., Sato, T., Takahashi, Toshihisa, Wakabayashi, Toshishige, Konishi, Kohji, Izumi, Ryohei, Miyashita, Tadashi, Suzuki, Takashi, Tsunoda, Tsukasa, Tsuchiya, Ryoichi, Fujiwara, Akira, Okajima, Kunio, Tabuchi, Yoshiki, Saitoh, Yoichi, Takahashi, Hiroshi, Muramatsu, Yukio, Yamada, Tatsuya, Uehara, Koichiro, Mishima, Yoshio, Fukuda, Ichiro, Imaoka, Shingi, Hiramatsu, K., Ido, K., and Takahashi, Takashi

Published
1986
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23. Proceedings of the 72nd general meeting Niigata, Japan, March 27–29, 1986

Author

Uchida, Katsuyuki, Watanabe, Hidenobu, Inui, K., Nakazawa, S., Suyama, Masafumi, Ariyama, Joe, Kakita, Akira, Kambayashi, Masaaki, Takahashi, Tsuyoshi, Saji, Yutaka, Takahashi, Masatoshi, Tsuburaya, Toshihiko, Uchino, Junichi, Ogura, Yoshifumi, Yamagiwa, Hiroshi, Wada, Yoshiyuki, Nagai, Hideo, Kuroda, Akira, Morioka, Yasuhiko, Yoshikawa, Tatsuya, Hanyu, Fujio, Tsunoda, Tsukasa, Tsuchiya, Ryoichi, Ouchi, Kiyoaki, Sato, Toshio, Kawaguchi, Hidehiro, Yoshida, Keisuke, Ishihara, Yukio, Sugiyama, Masanori, Kimura, Toshinari, Ibayashi, Hiroshi, Isaji, Shuji, Mizumoto, Ryuji, Ogawa, Michio, Mori, Takesada, Koizumi, Masaru, Fukao, Akira, Oguchi, Hisao, Kawa, Shigeyuki, Takemori, Yasuhiro, Sawabu, Norio, Ichihara, Toru, Nakao, Akimasa, Ishii, Hiromasa, Shigeta, Yohsuke, Matsuda, Yoshiro, Yasuhara, Minoru, Omata, Masao, Ito, Yoshimi, Takahashi, Toru, Himori, Masakado, Kamimura, Tomoteru, Ichida, Fumihiro, Koyama, Wataru, Hasumura, Yasushi, Inagaki, Takao, Sawaki, Shunji, Ichinohe, Akira, Itoh, Susumu, Komatsu, Masafumi, Tobori, Fumio, Inoue, Kyoichi, Aoyama, Keiichi, Abe, Hirohiko, Yamauchi, Kazuaki, Ohishi, Saburo, and Saibara, Toshiji

Published
1986
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24. Role of Endogenous Cholecystokinin in the Regeneration of Pancreatic Tissue after Acute Hemorrhagic Pancreatitis in Rats

Author

Wen-ling, SONG, Yamaguchi, Hiroya, Nakano, ltsuro, Kimura, Toshinari, and Nawata,Hajime

Subjects
regeneration, ストレス-セルレイン誘発膵炎, stress-cerulein induced pancreatitis, camostat, CR-1505, コレシストキニン, digestive system, cholecystokinin
Abstract

The aim of this study was to investigate the effect of endogenous cholecystokinin(CCK) on pancreatic regeneration after acute hemorrhagic pancreatitis. Acute hemorrhagic pancreatitis was induced in rats by two intraperitoneal cerulein injection(20μg/kg BW) with 5h water-immersion stress once a day for successive 3 days. After the cessation of repetition of acute pancreatitis the rats were treated with successive feeding with 0.1% camostat-containing diet or SC injection of CR-1505 (CCK receptor antagonist, 50 mg/kg BW X2/day) for 7 days. Zymogen enzymes and protein contents per DNA inpancreatic tissue were significantly higher in rats treated with camostat compared with control rats, and plasma CCK level was elevated. To the contrary, pancreatic regeneration was retarded in the rats treated with CR-1505. It is concluded that endogenous CCK has a trophic effect during regeneration after acute hemorrhagic pancreatitis., 本研究の目的は急性出血性膵炎後の膵再生における内因性コレシストキニン(CCK)の効果を検討することである. 急性出血性膵炎はラットに20μg/kg体重のセルンインを2回腹腔内注射して5時間の水浸拘束を1日1回3日間連続で行って誘発した. 急性膵炎の反復を終了後, ラットは引き続き7日間0.1%カモスタット含有食投与, あるいはCCK受容体拮抗剤であるCR 1505 50mg/kg体重を1日2回皮下注射した. 膵組織中のDNAあたりの分泌酵素含量と蛋白含量コントロールに比してカモスタット投与群では有意に高く血漿CCK濃度は上昇した. 一方, CR 1505処置ラットでは膵の再生は遅延した. 内因性CCKは急性膵炎後の再生期に栄養効果を有すると結論される.

Published
1996

25. Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis

Author

Ino, Yoshifumi, primary, Arita, Yoshiyuki, additional, Akashi, Tetsuro, additional, Kimura, Toshinari, additional, Igarashi, Hisato, additional, Oono, Takamasa, additional, Furukawa, Masayuki, additional, Kawabe, Ken, additional, Ogoshi, Keiichiro, additional, Ouchi, Jiro, additional, Miyahara, Toshihiko, additional, Takayanagi, Ryoichi, additional, and Ito, Tetsuhide, additional

Published
2008
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34. Horseshoe Anomaly of the Pancreas

Author

Yazu, Tsuyoshi, primary, Kimura, Toshinari, additional, Yamamoto, Ken, additional, Sumii, Toshihiko, additional, Arita, Yoshiyuki, additional, Takano, Soichiro, additional, Furukawa, Masayuki, additional, Tanaka, Masao, additional, Konomi, Kohki, additional, and Nawata, Hajime, additional

Published
1992
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45. Serum Elastase 1 Appears Specific for Cancer of the Pancreatic Head.

Author

Ito, Tetsuhide, Kimura, Toshinari, and Nawata, Hajime

Subjects
ELASTASES, SERUM, PANCREATIC cancer, PANCREATITIS, MOLECULAR weights
Abstract

Molecular size distribution of serum elastase 1 was investigated, by means of Sephadex G-200 gel filtration., in 10 patients with acute pancreatitis and in 19 patients with pancreatic cancer associated with high values of serum elastase 1. The elution profile of immunoreactive elastase 1 (IRE1) showed a single peak in the molecular position of the α1-antitrypsin-elastase 1 (α1-AT-E1) complex in all 10 patients with acute pancreatitis, six of seven patients with cancer of the pancreatic bodytail, and in the two patients with cancer of the pancreatic uncinate without poststenotic dilatation of the main pancreatic duct. The elution profile of all patients with pancreatic head cancer and one of seven patients with pancreatic body-tail cancer with a poststenotic dilatation of the main pancreatic duct showed two peaks: the first was eluted in the position of the α1-AT-E1 complex, and the second was eluted between α1-AT-E1 and elastase 1. The molecular weight of the IRE1 appearing specifically in patients with cancer of the pancreatic head was about 46,000 to 48,000, which was different from the 30,500 molecular weight of (pro)elastase 1. It is possible that proelastase 1 binding with an unknown substance exists in patients with pancreatic cancer. These data suggest that the stenosis or obstruction of the pancreatic duct by cancer probably liberates proelastase 1 from the normal pancreatic acinar cells into the blood. Therefore, the determination of the molecular size distribution of elastase 1 in the serum appears useful in the differential diagnosis of acute pancreatitis and pancreatic head cancer accompanied by pancreatitis. [ABSTRACT FROM AUTHOR]

Published
1991

46. Role of Prostaglandin E2in StimulisSecretion Coupling in Rat Exocrine Pancreas

Author

Ogami, Yoshimitsu, Kimura, Toshinari, and Nawata, Hajime

Abstract

Secretin (5 × 10−9-5 × 10−7M) increased enzyme secretion as well as cellular adenosine 3',5'-cyclic monophosphate (cyclic AMP) in a concentration- dependent manner in dispersed rat pancreatic acini. On the other hand, prostaglandin E2(10 μg/ml) induced an accumulation of the cellular cyclic AMP as observed by secretin (5 × 10−7M) but did not stimulate enzyme secretion. Furthermore, 10 μg/ml prostaglandin E2had a small inhibitory effect on the amylase release induced by maximal stimulation of secretin (5 ×10−7M), although the combination of prostaglandin E2and secretin caused a bigger increase in the cellular cyclic AMP than that induced by each alone (additive effect). An inhibitory effect of prostaglandin E2was also observed on the amylase release induced by maximal stimulation of caerulein (10−10M). Prostaglandin E, had no effect on either the resting or the caerulein-stimulated free cytosolic calcium concentration of the acinar cells measured using fura-2. These results suggest that the inhibitory effect is accounted for by the functionally compartmentalized cyclic AMP produced by prostaglandin E2or by another noncalcium mobilizing mechanism.

Published
1990

47. Activation of Proteases in CeruleinInduced Pancreatitis

Author

Yamaguchi, Hiroya, Kimura, Toshinari, Mimura, Kazuo, and Nawata, Hajime

Abstract

The activation of zymogen proteases and lysosomal enzyme cathepsin B in the pancreas was investigated in cerulein-induced pancreatitis in rats. Acute pancreatitis was induced by two intraperitoneal injections of 40 pg/kg of body weight of cerulein at intervals of 1 h. After the first cerulein injection, the active trypsin and elastase contents in the pancreas tissues significantly increased, and reached the highest level at 3 h after the first injection, followed by peaks at 5 h in the serum amylase and lipase levels and the pancreas wet weight. Cathepsin B contents in pancreas tissues showed a parallel increase with active zymogen enzymes during the first 3 h of pancreatitis. These findings may suggest that the intracellular activation of trypsinogen is an important step in the development of cerulein-induced acute pancreatitis and that cathepsin B plays a role in the activation of trypsinogen in pancreatic acinar cells.

Published
1989

48. Role of OxygenDerived Free Radicals in Hemorrhagic Pancreatitis Induced by Stress and Cerulein in Rats

Author

Furukawa, Masayuki, Kimura, Toshinari, Yamaguchi, Hiroya, Kinjoh, Mitsuru, and Nawata, Hajime

Abstract

The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis was studied in a new model of acute hemorrhagic pancreatitis and cerulein-induced edematous pancreatitis in rats. Hemorrhagic pancreatitis was produced by administering two intraper-itoneal doses of cerulein [40 μg/kg body weight (BW)] at 1-h intervals following water immersion stress applied for 5 h. Edematous pancreatitis was induced by injecting cerulein as described but without water immersion. Five hours after the first injection of cerulein, pancreatic edema and elevation of serum amylase level were more marked in the animals with hemorrhagic than with edematous pancreatitis. Five hours after the first injection of cerulein, marked hemorrhage and venous dilatation were observed only in those with hemorrhagic pancreatitis. Local pancreatic blood flow decreased to ∼60 of control values in the animals with edematous pancreatitis, and to ∼30 of control values in those with hemorrhagic pancreatitis. To evaluate the involvement of oxygen radicals, some rats received three intraperitoneal injections of superoxide dismutase (SOD 10,700 Ulkg BW) and cat-alase (132,000 U/kg BW) beginning 15 min before the first injection of cerulein and repeated at 1-h intervals. No significant effect of free radical scavengers was observed on the edematous pancreatitis. However, in hemorrhagic pancreatitis, treatment with SOD and catalase completely suppressed the hemorrhage and venous dilatation of the pancreas, significantly reduced the pancreatic wet weight and the serum amylase level, and reduced the histologic alterations. However, after treatment with SOD and catalase, no differences were observed in local pancreatic blood flow. These findings indicate that stress produced microvascular damage such as pancreatic hemorrhage following the generation of oxygen radicals, and that these radicals produced severe damage to the pancreas.

Published
1994

49. PERFORATED DIVERTICULUM OF THE TRANSVERSE COLON.

Author

Yamamoto, Manabu, Okamura, Takashi, Tomikawa, Morimasa, Kido, Yuichirou, Shiraishi, Morio, Kimura, Toshinari, and Sugimachi, Keizo

Subjects
DIVERTICULITIS, COLON diseases, APPENDICITIS, ULTRASONIC imaging, TOMOGRAPHY
Abstract

We report a case of perforated diverticulitis of the transverse colon. The preoperative diagnosis of perforated appendicitis was made on the basis of findings of both ultrasonography and CT. At surgery, an inflammatory mass resembling carcinoma was found in the transverse colon, and segmental resection was then performed. Diverticulitis of the transverse colon is rare, and there have been few reports in the English-language medical literature. This report describes a true diverticulum of the transverse colon that presented as acute diverticulitis. [ABSTRACT FROM AUTHOR]

Published
1997

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