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1,464 results on '"Kimmy"'

1. 1359 NTX-0471, engineered multivalent SIRPa and bispecific SIRPa-antiCCR4 molecules demonstrate superior activity providing path for mRNA expressed in-vivo biologics

Author

Weiqun Liu, Meredith Leong, Evan McCartney-Melstad, Colin McKinlay, Adrienne Sallets, Samuel Deutsch, Gunasekaran Kannan, Gowrisudha Adusumilli, Srinivasa Bandi, Shruti Lal, Ray Low, Ole Audun Haabeth, Pei-Ken Hsu, Kimmy Ferry, Anustha Sharma, and Jenna Triplett

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published
2023
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2. Psikoedukasi Sebagai Upaya Meningkatkan Pemahaman Kesiapan Perkawinan Bagi Remaja

Author

Martha Kurnia Asih, Shinta Pratiwi, Retno Ristiasih Utami, and Kimmy Katkar

Subjects
psychoeducation, marriage readiness, youth., Social Sciences, Science
Abstract

This service activity aims to increase the youth's understanding of the importance of resilience, including physical, psychological, and financial readiness. This service was implemented in psychoeducation with the target students in Kesatrian 2 Semarang Senior High School. This service instrument used a questionnaire and was analyzed by pretest and post-test. Based on the analysis using the Paired Sample T-Test, it was concluded that there was an increase of 14.31 with a mean pretest difference score of 72.54 and 86.81 post-test. It showed an increased understanding of adolescent marriage readiness after being given psychoeducation. The activities benefit adolescents with advanced knowledge of marriage readiness, including physical, psychological, and financial readiness.

Published
2023
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3. Do cognition and emotion matter? A study of COVID-19 vaccination decision-making in college students

Author

Nien-Tsu Nancy Chen, Kimmy Kee, Bianca T Villalobos, Miriam Ortiz, and HyeSun Lee

Subjects
Psychology, BF1-990
Abstract

The unparalleled speed of COVID-19 vaccine development has necessitated an expansion of existing knowledge on vaccination decision-making. The current study explored (1) how cognitions and emotions shaped college students’ COVID-19 vaccination decisions, and (2) where vaccination-inclined and vaccination-hesitant students converged and diverged in their decision-making process. Seventy-seven students participated in 26 focus groups to discuss their complex thoughts and feelings regarding COVID-19 vaccination, offering a more nuanced understanding of COVID-19 vaccination decision-making that has not been fully captured by quantitative studies. Thematic analysis found that vaccination-inclined participants and their hesitant counterparts reported differential patterns of positive and negative emotions, systematic appraisals, and heuristics in decision-making. Future research should investigate the roles of hope and relief, non-health-related benefits of vaccination, social trust, and interpersonal influence in vaccination decision-making.

Published
2023
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4. Transtorno do Espectro Autista infantil e os desafios familiares: revisão integrativa de literatura

Author

João Victor de Almeida Farias, Kimmy Amâncio Silva Silva, Maiara Maria da Silva, Noemi Thomé Mendes, Rita Maria Santos Lima, Thalia Lima da Silva, Monique Carla da Silva, and Mara Cristina Ribeiro

Subjects
TEA, Diagnóstico, Relações familiares, Education, Science, Social Sciences
Abstract

O autismo infantil envolve alterações significativas nas áreas de socialização, cognição e comunicação, com quadros, muitas vezes persistentes e severos. Estes têm uma grande variação individual e exigem, com muita frequência, cuidados intensos por parte dos pais ou familiares, longos e permanentes períodos de dedicação integral. O estudo teve por objetivo investigar na literatura os desafios encontrados no cotidiano de famílias de crianças com TEA. Trata-se de uma revisão integrativa de literatura que utilizou as bases de dados SCIELO, LILACS e Google Acadêmico para a coleta dos dados. Por meio dos Descritores em Ciências da Saúde foram utilizados para a busca os termos “Transtorno do Espectro Autista”, “Diagnóstico" e Relações Familiares'', sendo que o primeiro termo foi cruzado com os demais. Os critérios de inclusão foram artigos na íntegra, publicados nas línguas portuguesa, inglesa e espanhola, nos últimos quatro anos (2018 a 2022). A primeira busca registrou um achado de 115 artigos na base de dados LILACS e 22 artigos na base de dados SCIELO e 95 artigos no Google Acadêmico. Após a aplicação dos critérios de inclusão e exclusão, chegou-se a um total de 9 artigos. Observou-se a partir das literaturas incluídas nesta revisão que o TEA pode afetar significativamente a rotina da família, devido ao aumento das dificuldades e incertezas que a família passa a ter após o diagnóstico. Considerando o impacto que as famílias vivenciam, é preciso que as dificuldades das mesmas sejam trabalhadas através de uma atenção especializada.

Published
2023
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5. Pelatihan Resiliensi pada Remaja Panti Asuhan

Author

Kimmy Katkar, Purwaningtyastuti Pungky, and Retno Ristiasih Utami

Subjects
youth, resilience, Social Sciences
Abstract

Adolescents who live in orphanages will only have their physiological needs met but not their psychological needs, this is because the condition of the orphanage with the number of caregivers and orphans that are not comparable can cause psychological problems. The lack of guidance from caregivers in more depth can be one of the triggering factors for adolescents who live in orphanages when experiencing problems in their lives to be more susceptible to stress, pressure and depression. This makes it easy for individuals to fall and find it difficult to get back up. The implementation method in this service activity is carried out offline by giving lectures, case studies and games. Activities were evaluated using the pretest and post-test measurement models. Based on the results of the analysis using the Paired Sample T-Test, it was found that there was an increase of 17.98 with a difference in the mean score of pretest 56.95 and post-test 74.93. This shows an increase in resilience in orphaned adolescents after being given training. The activities that have been carried out are very useful for adolescents by increasing resilience and gaining new knowledge which before this activity teenagers did not know the meaning and importance of individuals having high resilience.

Published
2021
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6. Predicting Punctuation in Ancient Chinese Texts: A Multi-Layered LSTM and Attention-Based Approach

Author

Cai, Tracy, Chang, Kimmy, and Nabi, Fahad

Subjects
Computer Science - Computation and Language
Abstract

It was only until the 20th century when the Chinese language began using punctuation. In fact, many ancient Chinese texts contain thousands of lines with no distinct punctuation marks or delimiters in sight. The lack of punctuation in such texts makes it difficult for humans to identify when there pauses or breaks between particular phrases and understand the semantic meaning of the written text (Mogahed, 2012). As a result, unless one was educated in the ancient time period, many readers of ancient Chinese would have significantly different interpretations of the texts. We propose an approach to predict the location (and type) of punctuation in ancient Chinese texts that extends the work of Oh et al (2017) by leveraging a bidirectional multi-layered LSTM with a multi-head attention mechanism as inspired by Luong et al.'s (2015) discussion of attention-based architectures. We find that the use of multi-layered LSTMs and multi-head attention significantly outperforms RNNs that don't incorporate such components when evaluating ancient Chinese texts.

Published
2024

7. Ontology for Voice, Instruments, and Ensembles (OnVIE): Revisiting the Medium of Performance Concept for Enhanced Discoverability

Author

Kimmy Szeto

Subjects
Bibliography. Library science. Information resources
Abstract

Medium of performance—instruments, voices, and devices—is a frequent starting point in library users’ search for music resources. However, content and encoding standards for library cataloging have not been developed in a way that enables clear and consistent recording of medium of performance information. Consequently, unless specially configured, library discovery systems do not display medium of performance or provide this access point. Despite efforts to address this issue in the past decade in RDA, MARC, and the linked data environment, medium of performance information continues to be imprecise, dispersed across multiple fields or properties, and implied in other data elements. This article proposes revised definitions for “part,” “medium,” “performer,” and “ensemble,” along with a linked data model, the Ontology for Voice, Instruments, and Ensembles (OnVIE), that captures precise and complete medium of performance data reflecting music compositional practices, performance practices, and publishing conventions. The result is an independent medium of performance framework for recording searchable and machine-actionable metadata that can be hooked on to established library metadata ontologies and is widely applicable to printed and recorded classical, popular, jazz, and folk music. The clarity, simplicity, and extensibility of this model enable machine parsing so that the data can be searched, filtered, sorted, and displayed in multiple, creative ways.

Published
2022

8. Plant–plant interactions change during succession on nurse logs in a northern temperate rainforest

Author

Carrie L. Woods, Katy Maleta, and Kimmy Ortmann

Subjects
determinants of plant community structure, moss, nurse log, Olympic rainforest, plant–plant interactions, Stress Gradient Hypothesis, Ecology, QH540-549.5
Abstract

Abstract Plant–plant interactions change through succession from facilitative to competitive. At early stages of succession, early‐colonizing plants can increase the survival and reproductive output of other plants by ameliorating disturbance and stressful conditions. At later stages of succession, plant interactions are more competitive as plants put more energy toward growth and reproduction. In northern temperate rainforests, gap dynamics result in tree falls that facilitate tree regeneration (nurse logs) and bryophyte succession. How bryophyte‐tree seedling interactions vary through log succession remains unclear. We examined the relationships of tree seedlings, bryophyte community composition, bryophyte depth, and percent canopy cover in 166 1.0 m2 plots on nurse logs and the forest floor in the Hoh rainforest in Washington, USA, to test the hypothesis that bryophyte‐tree seedling interactions change from facilitative to competitive as the log decays. Tree seedling density was highest on young logs with early‐colonizing bryophyte species (e.g., Rhizomnium glabrescens) and lowest on decayed logs with Hylocomium splendens, a long‐lived moss that reaches depths >20 cm. As a result, bryophyte depth increased with nurse log decay and was negatively associated with tree seedling density. Tree seedling density was 4.6× higher on nurse logs than on the forest floor, which was likely due to competitive exclusion by forest floor plants, such as H. splendens. Nurse logs had 17 species of bryophytes while the forest floor had six, indicating that nurse logs contribute to maintaining bryophyte diversity. Nurse logs enable both tree seedlings and smaller bryophyte species to avoid competition with forest floor plants, including the dominant bryophyte, H. splendens. H. splendens is likely a widespread driver of plant community structure given its dominance in northern temperate forests. Our findings indicate that plant–plant interactions shift with succession on nurse logs from facilitative to competitive and, thus, influence forest community structure and dynamics.

Published
2021
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9. Collagen Matrices Mediate Glioma Cell Migration Induced by an Electrical Signal

Author

Li Yao, Kimmy Tran, and Diana Nguyen

Subjects
collagen, migration, electric field, glioma, astrocyte, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65
Abstract

Glioma cells produce an increased amount of collagen compared with normal astrocytes. The increasing amount of collagen in the extracellular matrix (ECM) modulates the matrix structure and the mechanical properties of the microenvironment, thereby regulating tumor cell invasion. Although the regulation of tumor cell invasion mainly relies on cell–ECM interaction, the electrotaxis of tumor cells has attracted great research interest. The growth of glioma cells in a three-dimensional (3D) collagen hydrogel creates a relevant tumor physiological condition for the study of tumor cell invasion. In this study, we tested the migration of human glioma cells, fetal astrocytes, and adult astrocytes in a 3D collagen matrix with different collagen concentrations. We report that all three types of cells demonstrated higher motility in a low concentration of collagen hydrogel (3 mg/mL and 5 mg/mL) than in a high concentration of collagen hydrogel (10 mg/mL). We further show that human glioma cells grown in collagen hydrogels responded to direct current electric field (dcEF) stimulation and migrated to the anodal pole. The tumor cells altered their morphology in the gels to adapt to the anodal migration. The directedness of anodal migration shows a field strength-dependent response. EF stimulation increased the migration speed of tumor cells. This study implicates the potential role of an dcEF in glioma invasion and as a target of treatment.

Published
2022
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12. Stealth dark matter spectrum using LapH and Irreps

Author

Brower, Richard C., Culver, Christopher, Cushman, Kimmy K., Fleming, George T., Hasenfratz, Anna, Howarth, Dean, Ingoldby, James, Jin, Xiao Yong, Kribs, Graham D., Meyer, Aaron S., Neil, Ethan T., Osborn, James C., Owen, Evan, Park, Sungwoo, Rebbi, Claudio, Rinaldi, Enrico, Schaich, David, Vranas, Pavlos, Weinberg, Evan, and Witzel, Oliver

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

We present non-perturbative lattice calculations of the low-lying meson and baryon spectrum of the SU(4) gauge theory with fundamental fermion constituents. This theory is one instance of stealth dark matter, a class of strongly coupled theories, where the lowest mass stable baryon is the dark matter candidate. This work constitutes the first milestone in the program to study stealth dark matter self-interactions. Here, we focus on reducing excited state contamination in the single baryon channel by applying the Laplacian Heaviside method, as well as projecting our baryon operators onto the irreducible representations of the octahedral group. We compare our resulting spectrum to previous work involving Gaussian smeared non-projected operators and find good agreement with reduced statistical uncertainties. We also present the spectrum of the low-lying odd-parity baryons for the first time., Comment: 19 pages, 9 figures

Published
2023

13. A Whole-Transcriptome Approach to Evaluating Reference Genes for Quantitative Gene Expression Studies: A Case Study in Mimulus

Author

Kimmy A. Stanton, Patrick P. Edger, Joshua R. Puzey, Taliesin Kinser, Philip Cheng, Daniel M. Vernon, Nancy R. Forsthoefel, and Arielle M. Cooley

Subjects
expression stability, Mimulus guttatus, Mimulus luteus, quantitative RT-PCR, RNA-seq, Genetics, QH426-470
Abstract

While quantitative PCR (qPCR) is widely recognized as being among the most accurate methods for quantifying gene expression, it is highly dependent on the use of reliable, stably expressed reference genes. With the increased availability of high-throughput methods for measuring gene expression, whole-transcriptome approaches may be increasingly utilized for reference gene selection and validation. In this study, RNA-seq was used to identify a set of novel qPCR reference genes and evaluate a panel of traditional “housekeeping” reference genes in two species of the evolutionary model plant genus Mimulus. More broadly, the methods proposed in this study can be used to harness the power of transcriptomes to identify appropriate reference genes for qPCR in any study organism, including emerging and nonmodel systems. We find that RNA-seq accurately estimates gene expression means in comparison to qPCR, and that expression means are robust to moderate environmental and genetic variation. However, measures of expression variability were only in agreement with qPCR for samples obtained from a shared environment. This result, along with transcriptome-wide comparisons, suggests that environmental changes have greater impacts on expression variability than on expression means. We discuss how this issue can be addressed through experimental design, and suggest that the ever-expanding pool of published transcriptomes represents a rich and low-cost resource for developing better reference genes for qPCR.

Published
2017
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14. Myotonic Dystrophy and Anesthetic Challenges: A Case Report and Review

Author

Chanchal Mangla, Kimmy Bais, and Joel Yarmush

Subjects
Anesthesiology, RD78.3-87.3
Abstract

Providing anesthesia to patients with myotonic dystrophy (DM) can be very challenging due to the multisystemic effects of the disease and extreme sensitivity of these patients to sedatives, opioids, and anesthetic agents. Other factors such as hypothermia, shivering, or mechanical or electric stimulation during surgery can precipitate myotonia which is difficult to abolish and can lead to further complications. Generally, local or regional anesthesia is preferred to avoid the complications associated with general anesthesia in this group. However there are several case reports of successful use of general anesthesia (with or without volatile agents and with or without opioids). These general anesthetic cases led to postoperative admission to the regular floor or ICU. We present a case of a woman with a history of DM who underwent robotic assisted laparoscopic hysterectomy under general anesthesia and was discharged home on the same day.

Published
2019
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16. Data Equity: Foundational Concepts for Generative AI

Author

Stonier, JoAnn, Woodman, Lauren, Alshammari, Majed, Cummings, Renée, Dad, Nighat, Garg, Arti, Busetto, Alberto Giovanni, Hsiao, Katherine, Hudson, Maui, Singh, Parminder Jeet, Kanamugire, David, Kapoor, Astha, Lei, Zheng, Lu, Jacqueline, Mizouni, Emna, Lungati, Angela Oduor, Loebel, María Paz Canales, Sethumadhavan, Arathi, Telford, Sarah, Sarin, Supheakmungkol, Bettinger, Kimmy, and Teeuwen, Stephanie

Subjects
Computer Science - Computers and Society
Abstract

This briefing paper focuses on data equity within foundation models, both in terms of the impact of Generative AI (genAI) on society and on the further development of genAI tools. GenAI promises immense potential to drive digital and social innovation, such as improving efficiency, enhancing creativity and augmenting existing data. GenAI has the potential to democratize access and usage of technologies. However, left unchecked, it could deepen inequities. With the advent of genAI significantly increasing the rate at which AI is deployed and developed, exploring frameworks for data equity is more urgent than ever. The goals of the briefing paper are threefold: to establish a shared vocabulary to facilitate collaboration and dialogue; to scope initial concerns to establish a framework for inquiry on which stakeholders can focus; and to shape future development of promising technologies. The paper represents a first step in exploring and promoting data equity in the context of genAI. The proposed definitions, framework and recommendations are intended to proactively shape the development of promising genAI technologies.

Published
2023

18. Female and male patients’ perceptions of primary care doctors’ communication skills in Hong Kong

Author

Vivienne Leung and Kimmy Cheng

Subjects
patient experience, patient satisfaction, healthcare, communication, Medicine (General), R5-920, Public aspects of medicine, RA1-1270
Abstract

This study examined how female and male patients perceive primary doctors’ communication skills in the Chinese context. To do so, this study specifically investigates female and male patients’ general perceptions toward primary care doctors’ communication skills in medical consultations. Specifically, this study focused on (a) female and male patients’ satisfaction level toward primary care doctors’ communication skills in medical consultations (b) female and male patients’ perception of the types of verbal and nonverbal communication skills applied by primary care doctors in medical consultations (c) as well as which gender of doctors with whom patients prefer to communicate during primary care medical consultations in Hong Kong. A purposive sampling survey of Hong Kong residents aged 18 or older was conducted in April 2014. A total of 450 completed questionnaires were received. All respondents have visited a public hospital for outpatient service in the past 2 years. Results showed that there were no patient gender differences in patients’ perceptions of doctors’ communication skills, both female and male patient respondents showed a preference for same-gender doctors. Interestingly, in contrast with prior research, male patient respondents in this study revealed a stronger preference for doctors of the same gender than female patient respondents did. Other differences, such as cultural norms, values and practices, rather than just gender differences, may account for patients’ perceptions of doctors’ communication skills.

Published
2016

20. Ruthenium-Based Catalytic Systems Incorporating a Labile Cyclooctadiene Ligand with N-Heterocyclic Carbene Precursors for the Atom-Economic Alcohol Amidation Using Amines

Author

Cheng Chen, Yang Miao, Kimmy De Winter, Hua-Jing Wang, Patrick Demeyere, Ye Yuan, and Francis Verpoort

Subjects
ruthenium (Ru), N-heterocyclic carbenes (NHCs), homogeneous catalysis, in situ, amide bonds, synthesis, Organic chemistry, QD241-441
Abstract

Transition-metal-catalyzed amide-bond formation from alcohols and amines is an atom-economic and eco-friendly route. Herein, we identified a highly active in situ N-heterocyclic carbene (NHC)/ruthenium (Ru) catalytic system for this amide synthesis. Various substrates, including sterically hindered ones, could be directly transformed into the corresponding amides with the catalyst loading as low as 0.25 mol.%. In this system, we replaced the p-cymene ligand of the Ru source with a relatively labile cyclooctadiene (cod) ligand so as to more efficiently obtain the corresponding poly-carbene Ru species. Expectedly, the weaker cod ligand could be more easily substituted with multiple mono-NHC ligands. Further high-resolution mass spectrometry (HRMS) analyses revealed that two tetra-carbene complexes were probably generated from the in situ catalytic system.

Published
2018
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21. TECHNO-SERVICE-PROFIT CHAIN: THE IMPACTS OF IOT-ENABLED ALGORITHMIC CUSTOMER SERVICE SYSTEMS FROM AN INTERDISCIPLINARY PERSPECTIVE.

Author

Liwei Chen, Hsieh, J. J. Po-An, and Kimmy Wa Chan

Abstract

The infusion of emerging technologies (e.g., IoT-enabled algorithmic customer service systems [IACSs]) often brings disruptive changes to customer service. In particular, the agentic nature of these technologies challenges prominent service theories. Among these challenges, recent scholarly calls have pushed for more research on the infusion of emerging technologies into the service-profit chain (SPC) framework, advocating for the importance of extended knowledge to develop a techno-infused version of the SPC. Thus, from an interdisciplinary perspective, we draw upon role theory and propose a technoservice-profit chain (TSPC). Specifically, we contextualize the SPC in the technoservice context with different approaches, including decomposing context-specific constructs and theorizing IACS implementation as a contextual factor that moderates TSPC relationships. Using a sequential mixed methods design combining quantitative and qualitative approaches, we tested our research model by conducting multiwave surveys and follow-up interviews in a large business-to-business service firm with data from employees, supervisors, and customers before and after IACS implementation. This interdisciplinary study contributes to the information systems, service marketing, and management literatures by enriching the compositions of core SPC constructs, theorizing interactions between human agents and technology agents, and scrutinizing the impacts of technology agents on the linkages between internal employee management and external customer service. Our results further reveal the emerging issues of competing bosses (i.e., supervisors and IACSs), competing employees (i.e., employees and IACSs), and the unintended dehumanization effects of IACSs on supervisors and employees. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Snowmass Theory Frontier: Astrophysics and Cosmology

Author

Green, Daniel, Ruderman, Joshua T., Safdi, Benjamin R., Shelton, Jessie, Achúcarro, Ana, Adshead, Peter, Akrami, Yashar, Baryakhtar, Masha, Baumann, Daniel, Berlin, Asher, Blinov, Nikita, Boddy, Kimberly K., Buschmann, Malte, Cabass, Giovanni, Caldwell, Robert, Castorina, Emanuele, Chen, Thomas Y., Chen, Xingang, Coulton, William, Croon, Djuna, Cui, Yanou, Curtin, David, Cyr-Racine, Francis-Yan, Dessert, Christopher, Dienes, Keith R., Draper, Patrick, Du, Peizhi, Ellis, Sebastian A. R., Essig, Rouven, Flauger, Raphael, Fong, Chee Sheng, Foster, Joshua W., Fumagalli, Jacopo, Harigaya, Keisuke, Horiuchi, Shunsaku, Ivanov, Mikhail M., Kahn, Yonatan, Knapen, Simon, Leane, Rebecca K., Lee, Hayden, Lentz, Erik W., Lewandowski, Matthew, Lisanti, Mariangela, Long, Andrew J., Loverde, Marilena, Maleknejad, Azadeh, McAllister, Liam, McDermott, Samuel D., McGehee, Robert, Meerburg, P. Daniel, Meyers, Joel, Dizgah, Azadeh Moradinezhad, Münchmeyer, Moritz, Outmezguine, Nadav Joseph, Pajer, Enrico, Palma, Gonzalo A., Parikh, Aditya, Park, Jong-Chul, Peter, Annika H. G., Pimentel, Guilherme L., Renaux-Petel, Sébastien, Rodd, Nicholas L., Shakya, Bibhushan, Shiu, Gary, Silverstein, Eva, Simonovic, Marko, Singh, Rajeev, Sleight, Charlotte, Takhistov, Volodymyr, Tanedo, Philip, Taronna, Massimo, Thomas, Brooks, Toro, Natalia, Tsai, Yu-Dai, Vitagliano, Edoardo, Vogelsberger, Mark, Wallisch, Benjamin, Wandelt, Benjamin D., Wechsler, Risa H., Weniger, Christoph, Wu, W. L. Kimmy, Xu, Weishuang Linda, Yamada, Masaki, Yu, Hai-Bo, Zhang, Zhengkang, Zhong, Yi-Ming, and Zurek, Kathryn

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Theory
Abstract

We summarize progress made in theoretical astrophysics and cosmology over the past decade and areas of interest for the coming decade. This Report is prepared as the TF09 "Astrophysics and Cosmology" topical group summary for the Theory Frontier as part of the Snowmass 2021 process., Comment: 57 pages

Published
2022

23. Lattice QCD and Particle Physics

Author

Kronfeld, Andreas S., Bhattacharya, Tanmoy, Blum, Thomas, Christ, Norman H., DeTar, Carleton, Detmold, William, Edwards, Robert, Hasenfratz, Anna, Lin, Huey-Wen, Mukherjee, Swagato, Orginos, Konstantinos, Brower, Richard, Cirigliano, Vincenzo, Davoudi, Zohreh, Jóo, Bálint, Jung, Chulwoo, Lehner, Christoph, Meinel, Stefan, Neil, Ethan T., Petreczky, Peter, Richards, David G., Bazavov, Alexei, Catterall, Simon, Dudek, Jozef J., El-Khadra, Aida X., Engelhardt, Michael, Fleming, George T., Giedt, Joel, Gupta, Rajan, Hansen, Maxwell T., Izubuchi, Taku, Karsch, Frithjof, Laiho, Jack, Liu, Keh-Fei, Meyer, Aaron S., Rinaldi, Enrico, Savage, Martin, Schaich, David, Shanahan, Phiala E., Sharpe, Stephen R., Sufian, Raza, Syritsyn, Sergey, Van de Water, Ruth S., Wagman, Michael L., Weinberg, Evan, Witzel, Oliver, Aubin, Christopher, Boyle, Peter, Chandrasekharan, Shailesh, Clöet, Ian C., Constantinou, Martha, Cushman, Kimmy, DeGrand, Thomas, Fodor, Zoltan, Foreman, Sam, Gottlieb, Steven, Hoying, Daniel, Jang, Yong-Chull, Jay, William I., Jin, Xiao-Yong, Kelly, Christopher, Kuti, Julius, Lamm, Henry, Lin, Meifeng, Lin, Yin, Lytle, Andrew T., Mackenzie, Paul, Mandula, Jeffrey, Meurice, Yannick, Monahan, Christopher, Morningstar, Colin, Osborn, James C., Park, Sungwoo, Simone, James N., Strelchenko, Alexei, Tomii, Masaaki, Vaquero, Alejandro, Vranas, Pavlos, Wang, Bigeng, Wilcox, Walter, Yoon, Boram, and Zhao, Yong

Subjects
High Energy Physics - Lattice, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Contribution from the USQCD Collaboration to the Proceedings of the US Community Study on the Future of Particle Physics (Snowmass 2021)., Comment: 27 pp. main text, 4 pp. appendices, 29 pp. references, 1 p. index

Published
2022

24. Forecasting ground-based sensitivity to the Rayleigh scattering of the CMB in the presence of astrophysical foregrounds

Author

Dibert, Karia R., Anderson, Adam J., Bender, Amy N., Benson, Bradford A., Bianchini, Federico, Carlstrom, John E., Crawford, Thomas M., Omori, Yuuki, Pan, Zhaodi, Raghunathan, Srinivasan, Reichardt, Christian L., and Wu, W. L. Kimmy

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Rayleigh scattering of cosmic microwave background (CMB) photons off the neutral hydrogen produced during recombination effectively creates an additional scattering surface after recombination that encodes new cosmological information, including the expansion and ionization history of the universe. A first detection of Rayleigh scattering is a tantalizing target for next-generation CMB experiments. We have developed a Rayleigh scattering forecasting pipeline that includes instrumental effects, atmospheric noise, and astrophysical foregrounds (e.g., Galactic dust, cosmic infrared background, or CIB, and the thermal Sunyaev-Zel'dovich effect). We forecast the Rayleigh scattering detection significance for several upcoming ground-based experiments, including SPT-3G+, Simons Observatory, CCAT-prime, and CMB-S4, and examine the limitations from atmospheric and astrophysical foregrounds as well as potential mitigation strategies. When combined with Planck data, we estimate that the ground-based experiments will detect Rayleigh scattering with a significance between 1.6 and 3.7, primarily limited by atmospheric noise and the CIB., Comment: 19 pages, 7 figures (v2 additional author added)

Published
2022
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25. Snowmass2021 Cosmic Frontier: Cosmic Microwave Background Measurements White Paper

Author

Chang, Clarence L., Huffenberger, Kevin M., Benson, Bradford A., Bianchini, Federico, Chluba, Jens, Delabrouille, Jacques, Flauger, Raphael, Hanany, Shaul, Jones, William C., Kogut, Alan J., McMahon, Jeffrey J., Meyers, Joel, Sehgal, Neelima, Simon, Sara M., Umilta, Caterina, Abazajian, Kevork N., Ahmed, Zeeshan, Akrami, Yashar, Anderson, Adam J., Ansarinejad, Behzad, Austermann, Jason, Baccigalupi, Carlo, Barkats, Denis, Barron, Darcy, Barry, Peter S., Battaglia, Nicholas, Baxter, Eric, Beck, Dominic, Bender, Amy N., Bennett, Charles, Beringue, Benjamin, Bischoff, Colin, Bleem, Lindsey, Bock, James, Bolliet, Boris, Bond, J Richard, Borrill, Julian, Brinckmann, Thejs, Brown, Michael L., Calabrese, Erminia, Carlstrom, John, Challinor, Anthony, Chang, Chihway, Chinone, Yuji, Clark, Susan E., Coulton, William, Cukierman, Ari, Cyr-Racine, Francis-Yan, Duff, Shannon M., Dvorkin, Cora, van Engelen, Alexander, Errard, Josquin, Eskilt, Johannes R., Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey, Freese, Katherine, Galitzki, Nicholas, Gawiser, Eric, Grin, Daniel, Grohs, Evan, Gruppuso, Alessandro, Gudmundsson, Jon E., Halverson, Nils W., Hamilton, Jean-Christophe, Harrington, Kathleen, Henrot-Versillé, Sophie, Hensley, Brandon, Hill, J. Colin, Hincks, Adam D., Hlozek, Renee, Holzapfel, William, Hotinli, Selim C., Hui, Howard, Ibitoye, Ayodeji, Johnson, Matthew, Johnson, Bradley R., Kang, Jae Hwan, Karkare, Kirit S., Knox, Lloyd, Kovac, John, Lau, Kenny, Legrand, Louis, Loverde, Marilena, Lubin, Philip, Ma, Yin-Zhe, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagy, Johanna, Niemack, Michael, Novosad, Valentine, Omori, Yuuki, Orlando, Giorgio, Pan, Zhaodi, Perotto, Laurence, Petroff, Matthew A., Pogosian, Levon, Pryke, Clem, Rahlin, Alexandra, Raveri, Marco, Reichardt, Christian L., Remazeilles, Mathieu, Rephaeli, Yoel, Ruhl, John, Schaan, Emmanuel, Shandera, Sarah, Shimon, Meir, Soliman, Ahmed, Stark, Antony A., Starkman, Glenn D., Stompor, Radek, Thakur, Ritoban Basu, Trendafilova, Cynthia, Tristram, Matthieu, Trivedi, Pranjal, Tucker, Gregory, Di Valentino, Eleonora, Vieira, Joaquin, Vieregg, Abigail, Wang, Gensheng, Watson, Scott, Wenzl, Lukas, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Zegeye, David, and Zhang, Cheng

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

This is a solicited whitepaper for the Snowmass 2021 community planning exercise. The paper focuses on measurements and science with the Cosmic Microwave Background (CMB). The CMB is foundational to our understanding of modern physics and continues to be a powerful tool driving our understanding of cosmology and particle physics. In this paper, we outline the broad and unique impact of CMB science for the High Energy Cosmic Frontier in the upcoming decade. We also describe the progression of ground-based CMB experiments, which shows that the community is prepared to develop the key capabilities and facilities needed to achieve these transformative CMB measurements., Comment: contribution to Snowmass 2021

Published
2022

26. Inflation: Theory and Observations

Author

Achúcarro, Ana, Biagetti, Matteo, Braglia, Matteo, Cabass, Giovanni, Caldwell, Robert, Castorina, Emanuele, Chen, Xingang, Coulton, William, Flauger, Raphael, Fumagalli, Jacopo, Ivanov, Mikhail M., Lee, Hayden, Maleknejad, Azadeh, Meerburg, P. Daniel, Dizgah, Azadeh Moradinezhad, Palma, Gonzalo A., Pimentel, Guilherme L., Renaux-Petel, Sébastien, Wallisch, Benjamin, Wandelt, Benjamin D., Witkowski, Lukas T., and Wu, W. L. Kimmy

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

Cosmic inflation provides a window to the highest energy densities accessible in nature, far beyond those achievable in any realistic terrestrial experiment. Theoretical insights into the inflationary era and its observational probes may therefore shed unique light on the physical laws underlying our universe. This white paper describes our current theoretical understanding of the inflationary era, with a focus on the statistical properties of primordial fluctuations. In particular, we survey observational targets for three important signatures of inflation: primordial gravitational waves, primordial non-Gaussianity and primordial features. With the requisite advancements in analysis techniques, the tremendous increase in the raw sensitivities of upcoming and planned surveys will translate to leaps in our understanding of the inflationary paradigm and could open new frontiers for cosmology and particle physics. The combination of future theoretical and observational developments therefore offer the potential for a dramatic discovery about the nature of cosmic acceleration in the very early universe and physics on the smallest scales., Comment: Contribution to Snowmass 2021; 103 pages, 8 figures, 378 endorsers; v2: minor changes

Published
2022

27. Snowmass 2021 CMB-S4 White Paper

Author

Abazajian, Kevork, Abdulghafour, Arwa, Addison, Graeme E., Adshead, Peter, Ahmed, Zeeshan, Ajello, Marco, Akerib, Daniel, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Amin, Mustafa A., Amiri, Mandana, Anderson, Adam, Ansarinejad, Behzad, Archipley, Melanie, Arnold, Kam S., Ashby, Matt, Aung, Han, Baccigalupi, Carlo, Baker, Carina, Bakshi, Abhishek, Bard, Debbie, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Barton, Paul, Thakur, Ritoban Basu, Battaglia, Nicholas, Beall, Jim, Bean, Rachel, Beck, Dominic, Belkner, Sebastian, Benabed, Karim, Bender, Amy N., Benson, Bradford A., Besuner, Bobby, Bethermin, Matthieu, Bhimani, Sanah, Bianchini, Federico, Biquard, Simon, Birdwell, Ian, Bischoff, Colin A., Bleem, Lindsey, Bocaz, Paulina, Bock, James J., Bocquet, Sebastian, Boddy, Kimberly K., Bond, J. Richard, Borrill, Julian, Bouchet, Francois R., Brinckmann, Thejs, Brown, Michael L., Bryan, Sean, Buza, Victor, Byrum, Karen, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chan, Victor, Chang, Clarence L., Chapman, Scott, Charles, Eric, Chauvin, Eric, Cheng, Cheng, Chesmore, Grace, Cheung, Kolen, Chinone, Yuji, Chluba, Jens, Cho, Hsiao-Mei Sherry, Choi, Steve, Clancy, Justin, Clark, Susan, Cooray, Asantha, Coppi, Gabriele, Corlett, John, Coulton, Will, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, Dai, Wei-Ming, Daley, Cail, Dart, Eli, Daues, Gregorg, de Haan, Tijmen, Deaconu, Cosmin, Delabrouille, Jacques, Derylo, Greg, Devlin, Mark, Di Valentino, Eleonora, Dierickx, Marion, Dober, Brad, Doriese, Randy, Duff, Shannon, Dutcher, Daniel, Dvorkin, Cora, Dünner, Rolando, Eftekhari, Tarraneh, Eimer, Joseph, Bouhargani, Hamza El, Elleflot, Tucker, Emerson, Nick, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Fanfani, Valentina, Fasano, Alessandro, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frisch, Josef, Frolov, Andrei, Galitzki, Nicholas, Gallardo, Patricio A., Galli, Silvia, Ganga, Ken, Gerbino, Martina, Giannakopoulos, Christos, Gilchriese, Murdock, Gluscevic, Vera, Goeckner-Wald, Neil, Goldfinger, David, Green, Daniel, Grimes, Paul, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Guarino, Vic, Gudmundsson, Jon E., Gullett, Ian, Guns, Sam, Habib, Salman, Haller, Gunther, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Hand, Emma, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Hensley, Brandon, Herbst, Ryan, Hervias-Caimapo, Carlos, Hill, J. Colin, Hills, Richard, Hivon, Eric, Hlozek, Renée, Ho, Anna, Holder, Gil, Hollister, Matt, Holzapfel, William, Hood, John, Hotinli, Selim, Hryciuk, Alec, Hubmayr, Johannes, Huffenberger, Kevin M., Hui, Howard, nez, Roberto Ibá, Ibitoye, Ayodeji, Ikape, Margaret, Irwin, Kent, Jacobus, Cooper, Jeong, Oliver, Johnson, Bradley R., Johnstone, Doug, Jones, William C., Joseph, John, Jost, Baptiste, Kang, Jae Hwan, Kaplan, Ari, Karkare, Kirit S., Katayama, Nobuhiko, Keskitalo, Reijo, King, Cesiley, Kisner, Theodore, Klein, Matthias, Knox, Lloyd, Koopman, Brian J., Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Krolewski, Alex, Kubik, Donna, Kuhlmann, Steve, Kuo, Chao-Lin, Kusaka, Akito, Lähteenmäki, Anne, Lau, Kenny, Lawrence, Charles R., Lee, Adrian T., Legrand, Louis, Leitner, Matthaeus, Leloup, Clément, Lewis, Antony, Li, Dale, Linder, Eric, Liodakis, Ioannis, Liu, Jia, Long, Kevin, Louis, Thibaut, Loverde, Marilena, Lowry, Lindsay, Lu, Chunyu, Lubin, Phil, Ma, Yin-Zhe, Maccarone, Thomas, Madhavacheril, Mathew S., Maldonado, Felipe, Mantz, Adam, Marques, Gabriela, Matsuda, Frederick, Mauskopf, Philip, May, Jared, McCarrick, Heather, McCracken, Ken, McMahon, Jeffrey, Meerburg, P. Daniel, Melin, Jean-Baptiste, Menanteau, Felipe, Meyers, Joel, Millea, Marius, Miranda, Vivian, Mitchell, Don, Mohr, Joseph, Moncelsi, Lorenzo, Monzani, Maria Elena, Moshed, Magdy, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagarajappa, Chandan, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Nerval, Simran, Newburgh, Laura, Nguyen, Hogan, Nichols, Erik, Nicola, Andrina, Niemack, Michael D., Nord, Brian, Norton, Tim, Novosad, Valentine, O'Brient, Roger, Omori, Yuuki, Orlando, Giorgio, Osherson, Benjamin, Osten, Rachel, Padin, Stephen, Paine, Scott, Partridge, Bruce, Patil, Sanjaykumar, Petravick, Don, Petroff, Matthew, Pierpaoli, Elena, Pilleux, Mauricio, Pogosian, Levon, Prabhu, Karthik, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Raghunathan, Srinivasan, Rahlin, Alexandra, Raveri, Marco, Reese, Ben, Reichardt, Christian L., Remazeilles, Mathieu, Rizzieri, Arianna, Rocha, Graca, Roe, Natalie A., Rotermund, Kaja, Roy, Anirban, Ruhl, John E., Saba, Joe, Sailer, Noah, Salatino, Maria, Saliwanchik, Benjamin, Sapozhnikov, Leonid, Rao, Mayuri Sathyanarayana, Saunders, Lauren, Schaan, Emmanuel, Schillaci, Alessandro, Schmitt, Benjamin, Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sherwin, Blake D., Shirokoff, Erik, Shiu, Corwin, Simon, Sara M., Singari, Baibhav, Slosar, Anze, Spergel, David, Germaine, Tyler St., Staggs, Suzanne T., Stark, Antony A., Starkman, Glenn D., Steinbach, Bryan, Stompor, Radek, Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Tandoi, Chris, Teply, Grant P., Thayer, Gregg, Thompson, Keith, Thorne, Ben, Timbie, Peter, Tomasi, Maurizio, Trendafilova, Cynthia, Tristram, Matthieu, Tucker, Carole, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, van Marrewijk, Joshiwa, Vavagiakis, Eve M., Vergès, Clara, Vieira, Joaquin D., Vieregg, Abigail G., Wagoner, Kasey, Wallisch, Benjamin, Wang, Gensheng, Wang, Guo-Jian, Watson, Scott, Watts, Duncan, Weaver, Chris, Wenzl, Lukas, Westbrook, Ben, White, Martin, Whitehorn, Nathan, Wiedlea, Andrew, Williams, Paul, Wilson, Robert, Winch, Harrison, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yefremenko, Volodymyr G., Yu, Cyndia, Zegeye, David, Zivick, Jeff, and Zonca, Andrea

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

This Snowmass 2021 White Paper describes the Cosmic Microwave Background Stage 4 project CMB-S4, which is designed to cross critical thresholds in our understanding of the origin and evolution of the Universe, from the highest energies at the dawn of time through the growth of structure to the present day. We provide an overview of the science case, the technical design, and project plan., Comment: Contribution to Snowmass 2021. arXiv admin note: substantial text overlap with arXiv:1908.01062, arXiv:1907.04473

Published
2022

28. Snowmass2021 CMB-HD White Paper

Author

Collaboration, The CMB-HD, Aiola, Simone, Akrami, Yashar, Basu, Kaustuv, Boylan-Kolchin, Michael, Brinckmann, Thejs, Bryan, Sean, Casey, Caitlin M., Chluba, Jens, Clesse, Sebastien, Cyr-Racine, Francis-Yan, Di Mascolo, Luca, Dicker, Simon, Essinger-Hileman, Thomas, Farren, Gerrit S., Fedderke, Michael A., Ferraro, Simone, Fuller, George M., Galitzki, Nicholas, Gluscevic, Vera, Grin, Daniel, Han, Dongwon, Hasselfield, Matthew, Hlozek, Renee, Holder, Gil, Hotinli, Selim C., Jain, Bhuvnesh, Johnson, Bradley, Johnson, Matthew, Klaassen, Pamela, MacInnis, Amanda, Madhavacheril, Mathew, Mandal, Sayan, Mauskopf, Philip, Meerburg, Daan, Meyers, Joel, Miranda, Vivian, Mroczkowski, Tony, Mukherjee, Suvodip, Munchmeyer, Moritz, Munoz, Julian, Naess, Sigurd, Nagai, Daisuke, Namikawa, Toshiya, Newburgh, Laura, Nguyen, Ho Nam, Niemack, Michael, Oppenheimer, Benjamin D., Pierpaoli, Elena, Raghunathan, Srinivasan, Schaan, Emmanuel, Sehgal, Neelima, Sherwin, Blake, Simon, Sara M., Slosar, Anze, Smith, Kendrick, Spergel, David, Switzer, Eric R., Trivedi, Pranjal, Tsai, Yu-Dai, van Engelen, Alexander, Wandelt, Benjamin D., Wollack, Edward J., and Wu, Kimmy

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

CMB-HD is a proposed millimeter-wave survey over half the sky that would be ultra-deep (0.5 uK-arcmin) and have unprecedented resolution (15 arcseconds at 150 GHz). Such a survey would answer many outstanding questions about the fundamental physics of the Universe. Major advances would be 1.) the use of gravitational lensing of the primordial microwave background to map the distribution of matter on small scales (k~10 h Mpc^(-1)), which probes dark matter particle properties. It will also allow 2.) measurements of the thermal and kinetic Sunyaev-Zel'dovich effects on small scales to map the gas density and velocity, another probe of cosmic structure. In addition, CMB-HD would allow us to cross critical thresholds: 3.) ruling out or detecting any new, light (< 0.1 eV) particles that were in thermal equilibrium with known particles in the early Universe, 4.) testing a wide class of multi-field models that could explain an epoch of inflation in the early Universe, and 5.) ruling out or detecting inflationary magnetic fields. CMB-HD would also provide world-leading constraints on 6.) axion-like particles, 7.) cosmic birefringence, 8.) the sum of the neutrino masses, and 9.) the dark energy equation of state. The CMB-HD survey would be delivered in 7.5 years of observing 20,000 square degrees of sky, using two new 30-meter-class off-axis crossed Dragone telescopes to be located at Cerro Toco in the Atacama Desert. Each telescope would field 800,000 detectors (200,000 pixels), for a total of 1.6 million detectors., Comment: Contribution to Snowmass 2021. Note some text overlap with CMB-HD Astro2020 APC and RFI (arXiv:1906.10134, arXiv:2002.12714). Science case further broadened and updated

Published
2022

29. Bias on Tensor-to-Scalar Ratio Inference With Estimated Covariance Matrices

Author

Beck, Dominic, Cukierman, Ari, and Wu, W. L. Kimmy

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We investigate simulation-based bandpower covariance matrices commonly used in cosmological parameter inferences such as the estimation of the tensor-to-scalar ratio $r$. We find that upper limits on $r$ can be biased low by tens of percent. The underestimation of the upper limit is most severe when the number of simulation realizations is similar to the number of observables. Convergence of the covariance-matrix estimation can require a number of simulations an order of magnitude larger than the number of observables, which could mean $\mathcal{O}(10\ 000)$ simulations. This is found to be caused by an additional scatter in the posterior probability of $r$ due to Monte Carlo noise in the estimated bandpower covariance matrix, in particular, by spurious non-zero off-diagonal elements. We show that matrix conditioning can be a viable mitigation strategy in the case that legitimate covariance assumptions can be made., Comment: 9 pages, 10 figures, accepted for publication in MNRAS

Published
2022
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31. Mitochondrial dysfunction and neurodegeneration in multiple sclerosis

Author

Kimmy eSu, Dennis eBourdette, and Michael eForte

Subjects
Mitochondria, Multiple Sclerosis, neurodegeneration, neuronal viability, p66ShcA, Physiology, QP1-981
Abstract

Multiple sclerosis (MS) has traditionally been considered an autoimmune inflammatory disorder leading to demyelination and clinical debilitation as evidenced by our current standard anti-inflammatory and immunosuppressive treatment regimens. While these approaches do control the frequency of clinical relapses, they do not prevent the progressive functional decline that plagues many people with MS. Many avenues of research indicate that a neurodegenerative process may also play a significant role in MS from the early stages of disease, and one of the current hypotheses identifies mitochondrial dysfunction as a key contributing mechanism. We have hypothesized that pathological permeability transition pore opening mediated by reactive oxygen species and calcium dysregulation is central to mitochondrial dysfunction and neurodegeneration in MS. This focused review highlights recent evidence supporting this hypothesis, with particular emphasis on our in vitro and in vivo work with the mitochondria-targeted redox enzyme p66ShcA.

Published
2013
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32. Integrating Insect Life History and Food Plant Phenology: Flexible Maternal Choice Is Adaptive

Author

Minghui Fei, Jeffrey A. Harvey, Berhane T. Weldegergis, Tzeyi Huang, Kimmy Reijngoudt, Louise M. Vet, and Rieta Gols

Subjects
endoparasitoid, foraging, glucosinolate, herbivore, herbivore induced plant volatile (HIPV), multivoltine, oviposition, rearing history, plant volatiles, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Experience of insect herbivores and their natural enemies in the natal habitat is considered to affect their likelihood of accepting a similar habitat or plant/host during dispersal. Growing phenology of food plants and the number of generations in the insects further determines lability of insect behavioural responses at eclosion. We studied the effect of rearing history on oviposition preference in a multivoltine herbivore (Pieris brassicae), and foraging behaviour in the endoparasitoid wasp (Cotesia glomerata) a specialist enemy of P. brassicae. Different generations of the insects are obligatorily associated with different plants in the Brassicaceae, e.g., Brassica rapa, Brassica nigra and Sinapis arvensis, exhibiting different seasonal phenologies in The Netherlands. Food plant preference of adults was examined when the insects had been reared on each of the three plant species for one generation. Rearing history only marginally affected oviposition preference of P. brassicae butterflies, but they never preferred the plant on which they had been reared. C. glomerata had a clear preference for host-infested B. rapa plants, irrespective of rearing history. Higher levels of the glucosinolate breakdown product 3-butenyl isothiocyanate in the headspace of B. rapa plants could explain enhanced attractiveness. Our results reveal the potential importance of flexible plant choice for female multivoltine insects in nature.

Published
2016
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33. Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges

Author

Michael eForte, Dennis eBourdette, and Kimmy eSu

Subjects
Mitochondria, Oxidative Stress, neuronal viability, p66ShcA, Physiology, QP1-981
Abstract

Mitochondria are essential to neuronal viability and function due to their roles in ATP production, intracellular calcium regulation, and activation of apoptotic pathways. Accordingly, mitochondrial dysfunction has been indicated in a wide variety of neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, stroke and multiple sclerosis (MS). Recent evidence points to the permeability transition pore (PTP) as a key player in mitochondrial dysfunction in these diseases, in which pathologic opening leads to mitochondrial swelling, rupture, release of cytochrome c, and neuronal death. Reactive oxygen species (ROS), which are inducers of PTP opening, have been prominently implicated in the progression of many of these neurodegenerative diseases. In this context, inactivation of a mitochondria-targeted redox enzyme p66ShcA (p66) has been recently shown to prevent the neuronal cell death leading to axonal severing in the murine model of MS, experimental autoimmune encephalomyelitis (EAE). To further characterize the response of neurons lacking p66, we assessed their reaction to treatment with oxidative stressors implicated in neurodegenerative pathways. Specifically, p66-knockout (p66-KO) and wild-type (WT) neurons were treated with hydrogen peroxide (H2O2) and nitric oxide (NO), and assessed for cell viability and changes in mitochondrial properties, including morphology and ROS production. The results showed that p66-KO neurons had greater survival following treatment with oxidative stressors and generated less ROS when compared to WT neurons. Correspondingly, mitochondria in p66-KO neurons showed diminished morphological changes in response to these challenges. Overall, these findings highlight the importance of developing mitochondria-targeted therapeutics for neurodegenerative disorders, and emphasize p66, mitochondrial ROS, and the PTP as key targets for maintaining mitochondrial and neuronal integrity.

Published
2012
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34. miR-132 mediates the integration of newborn neurons into the adult dentate gyrus.

Author

Bryan W Luikart, AeSoon L Bensen, Eric K Washburn, Julia V Perederiy, Kimmy G Su, Yun Li, Steven G Kernie, Luis F Parada, and Gary L Westbrook

Subjects
Medicine, Science
Abstract

Neuronal activity enhances the elaboration of newborn neurons as they integrate into the synaptic circuitry of the adult brain. The role microRNAs play in the transduction of neuronal activity into growth and synapse formation is largely unknown. MicroRNAs can influence the expression of hundreds of genes and thus could regulate gene assemblies during processes like activity-dependent integration. Here, we developed viral-based methods for the in vivo detection and manipulation of the activity-dependent microRNA, miR-132, in the mouse hippocampus. We find, using lentiviral and retroviral reporters of miR-132 activity, that miR-132 is expressed at the right place and right time to influence the integration of newborn neurons. Retroviral knockdown of miR-132 using a specific 'sponge' containing multiple target sequences impaired the integration of newborn neurons into the excitatory synaptic circuitry of the adult brain. To assess potential miR-132 targets, we used a whole-genome microarray in PC12 cells, which have been used as a model of neuronal differentiation. miR-132 knockdown in PC12 cells resulted in the increased expression of hundreds of genes. Functional grouping indicated that genes involved in inflammatory/immune signaling were the most enriched class of genes induced by miR-132 knockdown. The correlation of miR-132 knockdown to increased proinflammatory molecular expression may indicate a mechanistic link whereby miR-132 functions as an endogenous mediator of activity-dependent integration in vivo.

Published
2011
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37. There is no interest in precious stones in a vegetable market: the life and sermons of Rabbi Jacob Gordon of Toronto

Author

Kimmy Caplan

Subjects
Language and Literature, Judaism, BM1-990, Sociology (General), HM401-1281
Abstract

A preliminary examination of Rabbi Jacob Gordon’s sermons within their biographical, communal, religious, historical, social, and cultural contexts, offers insight into the challenges Jewish immigrants faced in early twentieth century Toronto—as this Orthodox immigrant rabbi perceived them. These sermons provide details and perspectives, and they particularly illuminate doings within Toronto’s Orthodox-immigrant Jewish community. Gordon’s East-European background did not hold him back from remolding his style, as well as the content of his sermons, fully aware as he was of the need to modify his sermonic approach to respond to the novelties of Toronto’s immigrant world. Gordon’s sermons may also be compared to those of other North American contemporaries, again signaling the unique aspects of the Canadian Jewish religious experience at a critical moment.

Published
2006
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39. DeepSZ: Identification of Sunyaev-Zel'dovich Galaxy Clusters using Deep Learning

Author

Lin, Zhen, Huang, Nicholas, Avestruz, Camille, Wu, W. L. Kimmy, Trivedi, Shubhendu, Caldeira, João, and Nord, Brian

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Galaxy clusters identified from the Sunyaev Zel'dovich (SZ) effect are a key ingredient in multi-wavelength cluster-based cosmology. We present a comparison between two methods of cluster identification: the standard Matched Filter (MF) method in SZ cluster finding and a method using Convolutional Neural Networks (CNN). We further implement and show results for a `combined' identifier. We apply the methods to simulated millimeter maps for several observing frequencies for an SPT-3G-like survey. There are some key differences between the methods. The MF method requires image pre-processing to remove point sources and a model for the noise, while the CNN method requires very little pre-processing of images. Additionally, the CNN requires tuning of hyperparameters in the model and takes as input, cutout images of the sky. Specifically, we use the CNN to classify whether or not an 8 arcmin $\times$ 8 arcmin cutout of the sky contains a cluster. We compare differences in purity and completeness. The MF signal-to-noise ratio depends on both mass and redshift. Our CNN, trained for a given mass threshold, captures a different set of clusters than the MF, some of which have SNR below the MF detection threshold. However, the CNN tends to mis-classify cutouts whose clusters are located near the edge of the cutout, which can be mitigated with staggered cutouts. We leverage the complementarity of the two methods, combining the scores from each method for identification. The purity and completeness of the MF alone are both 0.61, assuming a standard detection threshold. The purity and completeness of the CNN alone are 0.59 and 0.61. The combined classification method yields 0.60 and 0.77, a significant increase for completeness with a modest decrease in purity. We advocate for combined methods that increase the confidence of many lower signal-to-noise clusters.

Published
2021
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40. Breaking the degeneracy between polarization efficiency and cosmological parameters in CMB experiments

Author

Galli, Silvia, Wu, W. L. Kimmy, Benabed, Karim, Bouchet, François, Crawford, Thomas M., and Hivon, Eric

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Accurate cosmological parameter estimates using polarization data of the cosmic microwave background (CMB) put stringent requirements on map calibration, as highlighted in the recent results from the Planck satellite. In this paper, we point out that a model-dependent determination of polarization calibration can be achieved by the joint fit of the TE and EE CMB power spectra. This provides a valuable cross-check to band-averaged polarization efficiency measurements determined using other approaches. We demonstrate that, in $\Lambda$CDM, the combination of the TE and EE constrain polarization calibration with sub-percent uncertainty with Planck data and 2% uncertainty with SPTpol data. We arrive at similar conclusions when extending $\Lambda$CDM to include the amplitude of lensing $A_{\rm L}$, the number of relativistic species $N_{\rm eff}$, or the sum of the neutrino masses $\sum m_{\nu}$. The uncertainties on cosmological parameters are minimally impacted when marginalizing over polarization calibration, except, as can be expected, for the uncertainty on the amplitude of the primordial scalar power spectrum $\ln(10^{10} A_{\rm s})$, which increases by $20-50$%. However, this information can be fully recovered by adding TT data. For current and future ground-based experiments, SPT-3G and CMB-S4, we forecast the cosmological parameter uncertainties to be minimally degraded when marginalizing over polarization calibration parameters. In addition, CMB-S4 could constrain its polarization calibration at the level of $\sim$0.2% by combining TE and EE, and reach $\sim$0.06% by also including TT. We therefore conclude that relying on calibrating against Planck polarization maps, whose statistical uncertainty is limited to $\sim$0.5%, would be insufficient for upcoming experiments., Comment: 11 pages, 8 figures. Comments welcome

Published
2021
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41. CMB-S4: Forecasting Constraints on Primordial Gravitational Waves

Author

Collaboration, CMB-S4, Abazajian, Kevork, Addison, Graeme E., Adshead, Peter, Ahmed, Zeeshan, Akerib, Daniel, Ali, Aamir, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Amin, Mustafa A., Anderson, Adam, Arnold, Kam S., Ashton, Peter, Baccigalupi, Carlo, Bard, Debbie, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Thakur, Ritoban Basu, Battaglia, Nicholas, Bean, Rachel, Bebek, Chris, Bender, Amy N., Benson, Bradford A., Bianchini, Federico, Bischoff, Colin A., Bleem, Lindsey, Bock, James J., Bocquet, Sebastian, Boddy, Kimberly K., Bond, J. Richard, Borrill, Julian, Bouchet, François R., Brinckmann, Thejs, Brown, Michael L., Bryan, Sean, Buza, Victor, Byrum, Karen, Caimapo, Carlos Hervias, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chang, Clarence L., Chinone, Yuji, Cho, Hsiao-Mei Sherry, Cooray, Asantha, Coulton, Will, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, de Haan, Tijmen, Delabrouille, Jacques, Devlin, Mark, Di Valentino, Eleonora, Dierickx, Marion, Dobbs, Matt, Duff, Shannon, Dunkley, Jo, Dvorkin, Cora, Eimer, Joseph, Elleflot, Tucker, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frolov, Andrei, Galitzki, Nicholas, Gallardo, Patricio A., Galli, Silvia, Ganga, Ken, Gerbino, Martina, Gluscevic, Vera, Goeckner-Wald, Neil, Green, Daniel, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Gudmundsson, Jon E., Gullett, Ian, Gupta, Nikhel, Habib, Salman, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Hensley, Brandon, Hill, Charles, Hill, J. Colin, Hlozek, Renée, Ho, Shuay-Pwu Patty, Hoang, Thuong, Holder, Gil, Holzapfel, William, Hood, John, Hubmayr, Johannes, Huffenberger, Kevin M., Hui, Howard, Irwin, Kent, Jeong, Oliver, Johnson, Bradley R., Jones, William C., Kang, Jae Hwan, Karkare, Kirit S., Katayama, Nobuhiko, Keskitalo, Reijo, Kisner, Theodore, Knox, Lloyd, Koopman, Brian J., Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Kuhlmann, Steve, Kuo, Chao-lin, Kusaka, Akito, Lähteenmäki, Anne, Lawrence, Charles R., Lee, Adrian T., Lewis, Antony, Li, Dale, Linder, Eric, Loverde, Marilena, Lowitz, Amy, Lubin, Phil, Madhavacheril, Mathew S., Mantz, Adam, Marques, Gabriela, Matsuda, Frederick, Mauskopf, Philip, McCarrick, Heather, McMahon, Jeffrey, Meerburg, P. Daniel, Melin, Jean-Baptiste, Menanteau, Felipe, Meyers, Joel, Millea, Marius, Mohr, Joseph, Moncelsi, Lorenzo, Monzani, Maria, Mroczkowski, Tony, Mukherjee, Suvodip, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Newburgh, Laura, Niemack, Michael D., Nishino, Haruki, Nord, Brian, Novosad, Valentine, O'Brient, Roger, Padin, Stephen, Palladino, Steven, Partridge, Bruce, Petravick, Don, Pierpaoli, Elena, Pogosian, Levon, Prabhu, Karthik, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Rahlin, Alexandra, Rao, Mayuri Sathyanarayana, Raveri, Marco, Reichardt, Christian L., Remazeilles, Mathieu, Rocha, Graca, Roe, Natalie A., Roy, Anirban, Ruhl, John E., Salatino, Maria, Saliwanchik, Benjamin, Schaan, Emmanuel, Schillaci, Alessandro, Schmitt, Benjamin, Schmittfull, Marcel M., Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sherwin, Blake D., Shirokoff, Erik, Simon, Sara M., Slosar, Anze, Spergel, David, Germaine, Tyler St., Staggs, Suzanne T., Stark, Antony, Starkman, Glenn D., Stompor, Radek, Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Teply, Grant P., Thompson, Keith, Thorne, Ben, Timbie, Peter, Tomasi, Maurizio, Tristram, Matthieu, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, Vavagiakis, Eve M., Vieira, Joaquin D., Vieregg, Abigail G., Wagoner, Kasey, Wallisch, Benjamin, Wang, Gensheng, Watson, Scott, Westbrook, Ben, Whitehorn, Nathan, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yang, H. Y. Eric, Yasini, Siavash, Yefremenko, Volodymyr G., Yoon, Ki Won, Young, Edward, Yu, Cyndia, and Zonca, Andrea

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

CMB-S4---the next-generation ground-based cosmic microwave background (CMB) experiment---is set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the Universe, from the highest energies at the dawn of time through the growth of structure to the present day. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semi-analytic projection tool, targeted explicitly towards optimizing constraints on the tensor-to-scalar ratio, $r$, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2--3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments given a desired scientific goal. To form a closed-loop process, we couple this semi-analytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for $r > 0.003$ at greater than $5\sigma$, or, in the absence of a detection, of reaching an upper limit of $r < 0.001$ at $95\%$ CL., Comment: 24 pages, 8 figures, 9 tables, submitted to ApJ. arXiv admin note: text overlap with arXiv:1907.04473

Published
2020
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42. Near-conformal dynamics in a chirally broken system

Author

Appelquist, Thomas, Brower, Richard C., Cushman, Kimmy K., Fleming, George T., Gasbarro, Andrew D., Hasenfratz, Anna, Jin, Xiao-Yong, Neil, Ethan T., Osborn, James C., Rebbi, Claudio, Rinaldi, Enrico, Schaich, David, Vranas, Pavlos, and Witzel, Oliver

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Lattice
Abstract

Composite Higgs models must exhibit very different dynamics from quantum chromodynamics (QCD) regardless whether they describe the Higgs boson as a dilatonlike state or a pseudo-Nambu-Goldstone boson. Large separation of scales and large anomalous dimensions are frequently desired by phenomenological models. Mass-split systems are well-suited for composite Higgs models because they are governed by a conformal fixed point in the ultraviolet but are chirally broken in the infrared. In this work we use lattice field theory calculations with domain wall fermions to investigate a system with four light and six heavy flavors. We demonstrate how a nearby conformal fixed point affects the properties of the four light flavors that exhibit chiral symmetry breaking in the infrared. Specifically we describe hyperscaling of dimensionful physical quantities and determine the corresponding anomalous mass dimension. We obtain $y_m=1+\gamma^*= 1.47(5)$ suggesting that $N_f=10$ lies inside the conformal window. Comparing the low energy spectrum to predictions of dilaton chiral perturbation theory, we observe excellent agreement which supports the expectation that the 4+6 mass-split system exhibits near-conformal dynamics with a relatively light $0^{++}$ isosinglet scalar., Comment: 7 pages, 5 figures, v2 version published in Phys. Rev. D

Published
2020
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43. Hubble constant difference between CMB lensing and BAO measurements

Author

Wu, W. L. Kimmy, Motloch, Pavel, Hu, Wayne, and Raveri, Marco

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We apply a tension metric $Q_\textrm{UDM}$, the update difference in mean parameters, to understand the source of the difference in the measured Hubble constant $H_0$ inferred with cosmic microwave background lensing measurements from the Planck satellite ($H_0=67.9^{+1.1}_{-1.3}\, \mathrm{km/s/Mpc}$) and from the South Pole Telescope ($H_0=72.0^{+2.1}_{-2.5}\, \mathrm{km/s/Mpc}$) when both are combined with baryon acoustic oscillation (BAO) measurements with priors on the baryon density (BBN). $Q_\textrm{UDM}$ isolates the relevant parameter directions for tension or concordance where the two data sets are both informative, and aids in the identification of subsets of data that source the observed tension. With $Q_\textrm{UDM}$, we uncover that the difference in $H_0$ is driven by the tension between Planck lensing and BAO+BBN, at probability-to-exceed of 6.6%. Most of this mild tension comes from the galaxy BAO measurements parallel to the line of sight. The redshift dependence of the parallel BAOs pulls both the matter density $\Omega_m$ and $H_0$ high in $\Lambda$CDM, but these parameter anomalies are usually hidden when the BAO measurements are combined with other cosmological data sets with much stronger $\Omega_m$ constraints., Comment: 9 pages, 9 figures. Match published version

Published
2020
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44. Automated label flows for excited states of correlation functions in lattice gauge theory

Author

Cushman, Kimmy K. and Fleming, George T.

Subjects
High Energy Physics - Lattice
Abstract

Extracting excited states from lattice gauge theory correlation functions can be achieved through chi-squared minimization fits or algebraic approaches such as the variational method and Prony's method. Performing any kind of error analysis, such as bootstrap resampling, often leads to overlapping confidence regions of model parameters, even when the spectrum is not particularly dense. In order to correctly estimate errors, one must beware of mislabeling the states. In this work, we provide an algorithm that we call automated label flows which consistently and systematically identifies a deterministic labeling of states. In the context of Prony's method, we analyze lattice correlation functions by using automated label flows, and compare the results to fits obtained from chi-square minimization fits to exponentials., Comment: 15 pages, 20 figures, submitted to Phys. Rev. D

Published
2019
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48. CMB-S4 Decadal Survey APC White Paper

Author

Abazajian, Kevork, Addison, Graeme, Adshead, Peter, Ahmed, Zeeshan, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Amin, Mustafa A., Anderson, Adam, Arnold, Kam S., Baccigalupi, Carlo, Bailey, Kathy, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Thakur, Ritoban Basu, Battaglia, Nicholas, Baxter, Eric, Bean, Rachel, Bebek, Chris, Bender, Amy N., Benson, Bradford A., Berger, Edo, Bhimani, Sanah, Bischoff, Colin A., Bleem, Lindsey, Bock, James J., Bocquet, Sebastian, Boddy, Kimberly, Bonato, Matteo, Bond, J. Richard, Borrill, Julian, Bouchet, François R., Brown, Michael L., Bryan, Sean, Burkhart, Blakesley, Buza, Victor, Byrum, Karen, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chang, Clarence L., Chinone, Yuji, Cho, Hsiao-Mei Sherry, Cooray, Asantha, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, de Haan, Tijmen, de Zotti, Gianfranco, Delabrouille, Jacques, Demarteau, Marcel, Devlin, Mark, Di Valentino, Eleonora, Dobbs, Matt, Duff, Shannon, Duivenvoorden, Adriaan, Dvorkin, Cora, Edwards, William, Eimer, Joseph, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frolov, Andrei, Galitzki, Nicholas, Galli, Silvia, Ganga, Ken, Gerbino, Martina, Gilchriese, Murdock, Gluscevic, Vera, Green, Daniel, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Guarino, Victor, Gudmundsson, Jon E., Habib, Salman, Haller, Gunther, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Henning, Jason W., Hill, J. Colin, Hlozek, Renée, Holder, Gil, Holzapfel, William, Hubmayr, Johannes, Huffenberger, Kevin M., Huffer, Michael, Hui, Howard, Irwin, Kent, Johnson, Bradley R., Johnstone, Doug, Jones, William C., Karkare, Kirit, Katayama, Nobuhiko, Kerby, James, Kernovsky, Sarah, Keskitalo, Reijo, Kisner, Theodore, Knox, Lloyd, Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Kuhlmann, Steve, Kuo, Chao-lin, Kurita, Nadine, Kusaka, Akito, Lahteenmaki, Anne, Lawrence, Charles R., Lee, Adrian T., Lewis, Antony, Li, Dale, Linder, Eric, Loverde, Marilena, Lowitz, Amy, Madhavacheril, Mathew S., Mantz, Adam, Matsuda, Frederick, Mauskopf, Philip, McMahon, Jeff, Meerburg, P. Daniel, Melin, Jean-Baptiste, Meyers, Joel, Millea, Marius, Mohr, Joseph, Moncelsi, Lorenzo, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Negrello, Mattia, Newburgh, Laura, Niemack, Michael D., Nishino, Haruki, Nordby, Martin, Novosad, Valentine, O'Connor, Paul, Obied, Georges, Padin, Stephen, Pandey, Shivam, Partridge, Bruce, Pierpaoli, Elena, Pogosian, Levon, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Raghunathan, Srinivasan, Rahlin, Alexandra, Rajagopalan, Srini, Raveri, Marco, Reichanadter, Mark, Reichardt, Christian L., Remazeilles, Mathieu, Rocha, Graca, Roe, Natalie A., Roy, Anirban, Ruhl, John, Salatino, Maria, Saliwanchik, Benjamin, Schaan, Emmanuel, Schillaci, Alessandro, Schmittfull, Marcel M., Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sheehy, Christopher, Sherwin, Blake D., Shirokoff, Erik, Simon, Sara M., Slosar, Anze, Somerville, Rachel, Staggs, Suzanne T., Stark, Antony, Stompor, Radek, Story, Kyle T., Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Teply, Grant P., Thompson, Keith, Timbie, Peter, Tomasi, Maurizio, Treu, Jesse I., Tristram, Matthieu, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, Vieira, Joaquin D., Vieregg, Abigail G., Vogelsberger, Mark, Wang, Gensheng, Watson, Scott, White, Martin, Whitehorn, Nathan, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yasini, Siavash, Yeck, James, Yoon, Ki Won, Young, Edward, and Zonca, Andrea

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

We provide an overview of the science case, instrument configuration and project plan for the next-generation ground-based cosmic microwave background experiment CMB-S4, for consideration by the 2020 Decadal Survey., Comment: Project White Paper submitted to the 2020 Decadal Survey, 10 pages plus references. arXiv admin note: substantial text overlap with arXiv:1907.04473

Published
2019

49. CMB-S4 Science Case, Reference Design, and Project Plan

Author

Abazajian, Kevork, Addison, Graeme, Adshead, Peter, Ahmed, Zeeshan, Allen, Steven W., Alonso, David, Alvarez, Marcelo, Anderson, Adam, Arnold, Kam S., Baccigalupi, Carlo, Bailey, Kathy, Barkats, Denis, Barron, Darcy, Barry, Peter S., Bartlett, James G., Thakur, Ritoban Basu, Battaglia, Nicholas, Baxter, Eric, Bean, Rachel, Bebek, Chris, Bender, Amy N., Benson, Bradford A., Berger, Edo, Bhimani, Sanah, Bischoff, Colin A., Bleem, Lindsey, Bocquet, Sebastian, Boddy, Kimberly, Bonato, Matteo, Bond, J. Richard, Borrill, Julian, Bouchet, François R., Brown, Michael L., Bryan, Sean, Burkhart, Blakesley, Buza, Victor, Byrum, Karen, Calabrese, Erminia, Calafut, Victoria, Caldwell, Robert, Carlstrom, John E., Carron, Julien, Cecil, Thomas, Challinor, Anthony, Chang, Clarence L., Chinone, Yuji, Cho, Hsiao-Mei Sherry, Cooray, Asantha, Crawford, Thomas M., Crites, Abigail, Cukierman, Ari, Cyr-Racine, Francis-Yan, de Haan, Tijmen, de Zotti, Gianfranco, Delabrouille, Jacques, Demarteau, Marcel, Devlin, Mark, Di Valentino, Eleonora, Dobbs, Matt, Duff, Shannon, Duivenvoorden, Adriaan, Dvorkin, Cora, Edwards, William, Eimer, Joseph, Errard, Josquin, Essinger-Hileman, Thomas, Fabbian, Giulio, Feng, Chang, Ferraro, Simone, Filippini, Jeffrey P., Flauger, Raphael, Flaugher, Brenna, Fraisse, Aurelien A., Frolov, Andrei, Galitzki, Nicholas, Galli, Silvia, Ganga, Ken, Gerbino, Martina, Gilchriese, Murdock, Gluscevic, Vera, Green, Daniel, Grin, Daniel, Grohs, Evan, Gualtieri, Riccardo, Guarino, Victor, Gudmundsson, Jon E., Habib, Salman, Haller, Gunther, Halpern, Mark, Halverson, Nils W., Hanany, Shaul, Harrington, Kathleen, Hasegawa, Masaya, Hasselfield, Matthew, Hazumi, Masashi, Heitmann, Katrin, Henderson, Shawn, Henning, Jason W., Hill, J. Colin, Hlozek, Renée, Holder, Gil, Holzapfel, William, Hubmayr, Johannes, Huffenberger, Kevin M., Huffer, Michael, Hui, Howard, Irwin, Kent, Johnson, Bradley R., Johnstone, Doug, Jones, William C., Karkare, Kirit, Katayama, Nobuhiko, Kerby, James, Kernovsky, Sarah, Keskitalo, Reijo, Kisner, Theodore, Knox, Lloyd, Kosowsky, Arthur, Kovac, John, Kovetz, Ely D., Kuhlmann, Steve, Kuo, Chao-lin, Kurita, Nadine, Kusaka, Akito, Lahteenmaki, Anne, Lawrence, Charles R., Lee, Adrian T., Lewis, Antony, Li, Dale, Linder, Eric, Loverde, Marilena, Lowitz, Amy, Madhavacheril, Mathew S., Mantz, Adam, Matsuda, Frederick, Mauskopf, Philip, McMahon, Jeff, McQuinn, Matthew, Meerburg, P. Daniel, Melin, Jean-Baptiste, Meyers, Joel, Millea, Marius, Mohr, Joseph, Moncelsi, Lorenzo, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Nagai, Daisuke, Nagy, Johanna, Namikawa, Toshiya, Nati, Federico, Natoli, Tyler, Negrello, Mattia, Newburgh, Laura, Niemack, Michael D., Nishino, Haruki, Nordby, Martin, Novosad, Valentine, O'Connor, Paul, Obied, Georges, Padin, Stephen, Pandey, Shivam, Partridge, Bruce, Pierpaoli, Elena, Pogosian, Levon, Pryke, Clement, Puglisi, Giuseppe, Racine, Benjamin, Raghunathan, Srinivasan, Rahlin, Alexandra, Rajagopalan, Srini, Raveri, Marco, Reichanadter, Mark, Reichardt, Christian L., Remazeilles, Mathieu, Rocha, Graca, Roe, Natalie A., Roy, Anirban, Ruhl, John, Salatino, Maria, Saliwanchik, Benjamin, Schaan, Emmanuel, Schillaci, Alessandro, Schmittfull, Marcel M., Scott, Douglas, Sehgal, Neelima, Shandera, Sarah, Sheehy, Christopher, Sherwin, Blake D., Shirokoff, Erik, Simon, Sara M., Slosar, Anze, Somerville, Rachel, Spergel, David, Staggs, Suzanne T., Stark, Antony, Stompor, Radek, Story, Kyle T., Stoughton, Chris, Suzuki, Aritoki, Tajima, Osamu, Teply, Grant P., Thompson, Keith, Timbie, Peter, Tomasi, Maurizio, Treu, Jesse I., Tristram, Matthieu, Tucker, Gregory, Umiltà, Caterina, van Engelen, Alexander, Vieira, Joaquin D., Vieregg, Abigail G., Vogelsberger, Mark, Wang, Gensheng, Watson, Scott, White, Martin, Whitehorn, Nathan, Wollack, Edward J., Wu, W. L. Kimmy, Xu, Zhilei, Yasini, Siavash, Yeck, James, Yoon, Ki Won, Young, Edward, and Zonca, Andrea

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Experiment
Abstract

We present the science case, reference design, and project plan for the Stage-4 ground-based cosmic microwave background experiment CMB-S4., Comment: 287 pages, 82 figures

Published
2019

50. Prony methods for extracting excited states

Author

Cushman, Kimmy K. and Fleming, George T.

Subjects
High Energy Physics - Lattice
Abstract

We propose an algebraic method for extracting excited states from lattice gauge theory correlation functions. Instead of fitting to a sum of decaying exponentials, we adopt a variant of Prony's method to obtain $M$ energies (exponential decay rates) by finding the roots of an $M^{\rm th}$ order polynomial, and then solving for the amplitudes linearly. The resulting states tend to have overlapping error ellipses, making identification of states ambiguous. This is especially problematic at large Euclidean times where the signal to noise may be low, as well as when many states are extracted. We propose a variation of K-means clustering to identify each extracted state., Comment: 7 pages, 9 figures, Lattice 2018 proceedings

Published
2019

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