30 results on '"Kimmig, S."'
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2. Impact of long-term thermal exposure on a SiC fiber-reinforced copper matrix composite
- Author
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Kimmig, S., Elgeti, S., and You, Jeong-Ha
- Published
- 2013
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3. Strength and conductivity of unidirectional copper composites reinforced by continuous SiC fibers
- Author
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Kimmig, S., Allen, I., and You, J.H.
- Published
- 2013
- Full Text
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4. A locked mode indicator for disruption prediction on JET and ASDEX upgrade
- Author
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Sias, G, Cannas, B, Fanni, A, Murari, A, Pau, A, Kallenbach, A, Aguiam, D, Aho-Mantila, L, Angioni, C, Arden, N, Arredondo Parra, R, Asunta, O, de Baar, M, Balden, M, Behler, K, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boeswirth, B, Bottereau, C, Bottino, A, van den Brand, H, Brezinsek, S, Brida, D, Brochard, F, Bruhn, C, Buchanan, J, Buhler, A, Burckhart, A, Cambon-Silva, D, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carr, M, Carralero, D, Casali, L, Castaldo, C, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, D'Arcangelo, O, Day, C, Delogu, R, de Marne, P, Denk, S, Denner, P, Dibon, M, D'Inca, R, Di Siena, A, Douai, D, Drenik, A, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Erdos, B, Erofeev, I, Esposito, B, Fable, E, Faitsch, M, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Frassinetti, L, Freethy, S, Froeschle, M, Fuchert, G, Fuchs, J, Fuenfgelder, H, Galazka, K, Galdon-Quiroga, J, Gallo, A, Gao, Y, Garavaglia, S, Garcia-Munoz, M, Geiger, B, Cianfarani, C, Giannone, L, Giovannozzi, E, Gleason-Gonzalez, C, Gloeggler, S, Gobbin, M, Goerler, T, Goodman, T, Gorini, G, Gradic, D, Graeter, A, Granucci, G, Greuner, H, Griener, M, Groth, M, Gude, A, Guenter, S, Guimarais, L, Haas, G, Hakola, A, Ham, C, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hayward, T, Heinemann, B, Heinzel, S, Hellsten, T, Henderson, S, Hennequin, P, Herrmann, A, Heyn, E, Hitzler, F, Hobirk, J, Hoelzl, M, Hoeschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Ivanova-Stanik, I, Jacob, W, Jacobsen, A, Jacquot, J, Janky, F, Jardin, A, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Kasemann, C, Kalvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kasilov, S, Kernbichler, W, Kim, D, Kimmig, S, Kirk, A, Klingshirn, H, Koch, F, Kocsis, G, Koehn, A, Kraus, M, Krieger, K, Krivska, A, Kraemer-Flecken, A, Kurki-Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazanyi, N, Lazaros, A, Lebschy, A, Li, L, Li, M, Liang, Y, Lipschultz, B, Liu, Y, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Manas, P, Mancini, A, Manhard, A, Manso, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Martens, C, Martin, P, Marrelli, L, Martitsch, A, Mastrostefano, S, Mayer, A, Mayer, M, Mazon, D, Mccarthy, P, Mcdermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Merle, A, Mertens, V, Meshcheriakov, D, Meyer, H, Meyer, O, Miettunen, J, Milanesio, D, Mink, F, Mlynek, A, Monaco, F, Moon, C, Nazikian, R, Nemes-Czopf, A, Neu, G, Neu, R, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Noterdaeme, J, Nowak, S, Oberkofler, M, Oberparleiter, M, Ochoukov, R, Odstrcil, T, Olsen, J, Orain, F, Palermo, F, Papp, G, Paradela Perez, I, Pautasso, G, Enzel, F, Petersson, P, Pinzon, J, Piovesan, P, Piron, C, Plaum, B, Ploeckl, B, Plyusnin, V, Pokol, G, Poli, E, Porte, L, Potzel, S, Prisiazhniuk, D, Putterich, T, Ramisch, M, Rapson, C, Rasmussen, J, Raupp, G, Refy, D, Reich, M, Reimold, F, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez-Ramos, M, Rohde, V, Ross, A, Rott, M, Rubel, M, Ryan, D, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis-Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz-Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shabbir, A, Shalpegin, A, Shao, L, Sharapov, S, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommariva, C, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Suarez, G, Sugiyama, K, Sun, H, Suttrop, W, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Terranova, D, Tierens, W, Told, D, Tudisco, O, Trevisan, G, Treutterer, W, Trier, E, Tripsky, M, Valisa, M, Valovic, M, Vanovac, B, Varela, P, Varoutis, S, Verdoolaege, G, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, von Toussaint, U, Wagner, D, Wang, N, Wang, X, Weidl, M, Weiland, M, White, A, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Xiang, L, Yang, Q, Yang, Z, Yu, Q, Zagorski, R, Zammuto, I, Zarzoso, D, Zhang, W, van Zeeland, M, Zehetbauer, T, Zilker, M, Zoletnik2, S, Zohm, H, Adamek, J, Agostini, M, Ahn, J, Akers, R, Albanese, R, Aledda, R, Alessi, E, Allan, S, Alves, D, Ambrosino, R, Amicucci, L, Anand, H, Anastassiou, G, Andrebe, Y, Apruzzese, G, Ariola, M, Arnichand, H, Arter, W, Baciero, A, Barnes, M, Barrera, L, Behn, R, Bencze, A, Bettini, P, Bilkova, P, Bin, W, Bizarro, J, Blanchard, P, Blanken, T, Bluteau, M, Bogar, O, Bohm, P, Boncagni, L, Botrugno, A, Bouquey, F, Bourdelle, C, Bremond, S, Bufferand, H, Buratti, P, Cahyna, P, Calabro, G, Caniello, R, Canton, A, Cardinali, A, Carnevale, D, Castejon, F, Castro, R, Causa, F, Cavazzana, R, Cecconello, M, Ceccuzzi, S, Cesario, R, Chapman, S, Chernyshova, M, Choi, D, Ciraolo, G, Citrin, J, Corre, Y, Crisanti, F, Cruz, N, De Angeli, M, De Masi, G, De Temmerman, G, De Tommasi, G, Decker, J, Dendy, R, Di Troia, C, Dimitrova, M, Doric, V, Dudson, B, Dunai, D, Easy, L, Elmore, S, Fedorczak, N, Ferreira, J, Fevrier, O, Ficker, O, Figini, L, Figueiredo, A, Fil, A, Fishpool, G, Fitzgerald, M, Fontana, M, Fridstrom, R, Frigione, D, Fuchs, C, Furno Palumbo, M, Futatani, S, Gabellieri, L, Galeani, S, Gallart, D, Galperti, C, Garcia, J, Garcia-Carrasco, A, Garcia-Lopez, J, Gardarein, J, Garzotti, L, Gaspar, J, Gauthier, E, Geelen, P, Ghendrih, P, Ghezzi, F, Giacomelli, L, Giroud, C, Gleason Gonzalez, C, Gospodarczyk, M, Gruber, M, Guirlet, R, Gunn, J, Hacek, P, Hacquin, S, Hall, S, Harting, D, Havlickova, E, Helou, W, Heyn, M, Hnat, B, Holzl, M, Hogeweij, D, Honore, C, Horacek, J, Hornung, G, Huang, Z, Igitkhanov, J, Imrisek, M, Innocente, P, Ionita-Schrittwieser, C, Isliker, H, Jacquet, P, Jakubowski, M, Jeppe Miki Busk, O, Jessen, M, Jones, O, Jonsson, T, Kallinikos, N, Karpushov, A, Kasprowicz, G, Kendl, A, Kjer, S, Klimek, I, Kogut, D, Komm, M, Korsholm, S, Koslowski, H, Koubiti, M, Kovacic, J, Kovarik, K, Krawczyk, N, Krbec, J, Kube, R, Kudlacek, O, Labit, B, Laguardia, L, Lahtinen, A, Lalousis, P, Le, H, Leddy, J, Lefevre, L, Lehnen, M, Leipold, F, Lessig, A, Leyland, M, Loarer, T, Loarte, A, Loewenhoff, T, Lomanowski, B, Loschiavo, V, Lupelli, I, Lux, H, Maget, P, Maggi, C, Maggiora, R, Magnussen, M, Maljaars, B, Malygin, A, Marchand, B, Marconato, N, Marini, C, Marinucci, M, Markovic, T, Marocco, D, Martin Solis, J, Mattei, M, Matthews, G, Mavridis, M, Mayoral, M, Mcadams, R, Mcardle, G, Mcclements, K, Mcmillan, B, Militello, F, Miron, I, Mitosinkova, K, Mlynar, J, Molina, D, Molina, P, Monakhov, I, Morales, J, Moreau, D, Morel, P, Moret, J, Moro, A, Moulton, D, Mueller, H, Nabais, F, Nardon, E, Naulin, V, Nespoli, F, Nimb, S, Nouailletas, R, Omotani, J, O'Mullane, M, Osterman, N, Paccagnella, R, Pamela, S, Pangione, L, Panjan, M, Paprok, R, Parail, V, Parra, F, Pehkonen, S, Pereira, A, Perelli Cippo, E, Pericoli Ridolfini, V, Peterka, M, Petrzilka, V, Pironti, A, Pisano, F, Pisokas, T, Pitts, R, Ploumistakis, I, Poljak, D, Poloskei, P, Popovic, Z, Por, G, Predebon, I, Preynas, M, Primc, G, Pucella, G, Puiatti, M, Puetterich, T, Rack, M, Ramogida, G, Juul Rasmussen, J, Ratta, G, Ratynskaia, S, Ravera, G, Reimerdes, H, Reinke, M, Reiser, D, Resnik, M, Reux, C, Ripamonti, D, Riva, G, Rosato, J, Sabot, R, Saint-Laurent, F, Samaddar, D, Scannell, R, Scheffer, M, Schneider, M, Schneider, B, Seidl, J, Sesnic, S, Shanahan, B, Sheikh, U, Silva Fuglister, M, Spagnolo, S, Spizzo, G, Stange, T, Stejner Pedersen, M, Stepanov, I, Strand, P, Susnjara, A, Tamain, P, Teplukhina, A, Testa, D, Theiler, C, Thornton, A, Tolias, P, Tophoj, L, Tsironis, C, Tsui, C, Uccello, A, Urban, J, Vallejos, P, Vartanian, S, Vega, J, Verhaegh, K, Vermare, L, Vignitchouk, L, Vijvers, W, Villone, F, Viola, B, Vlahos, L, Voitsekhovitch, I, Vondracek, P, Vu, N, Walkden, N, Wauters, T, Weinzettl, V, Westerhof, E, Wiesenberger, M, Wodniak, I, Yadykin, D, Zanca, P, Zaplotnik, R, Zestanakis, P, Zuin, M, Litaudon, X, Abduallev, S, Abhangi, M, Abreu, P, Afzal, M, Aggarwal, K, Ahlgren, T, Aiba, N, Airila, M, Aldred, V, Alegre, D, Aleynikov, P, Alfier, A, Alkseev, A, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Amosov, V, Andersson Sunden, E, Angelone, M, Anghel, M, Appel, L, Appelbee, C, Arena, P, Arshad, S, Ash, A, Ashikawa, N, Aslanyan, V, Auriemma, F, Austin, Y, Avotina, L, Axton, M, Ayres, C, Bacharis, M, Baiao, D, Bailey, S, Baker, A, Balboa, I, Balshaw, N, Bament, R, Banks, J, Baranov, Y, Barnard, M, Barnes, D, Barnsley, R, Baron Wiechec, A, Barrera Orte, L, Baruzzo, M, Basiuk, V, Bassan, M, Bastow, R, Batista, A, Batistoni, P, Baughan, R, Bauvir, B, Baylor, L, Bazylev, B, Beal, J, Beaumont, P, Beckers, M, Beckett, B, Becoulet, A, Bekris, N, Beldishevski, M, Bell, K, Belli, F, Bellinger, M, Belonohy, E, Ben Ayed, N, Benterman, N, Bergsaker, H, Berry, M, Bertalot, L, Besliu, C, Bieg, B, Bielecki, J, Biewer, T, Bigi, M, Binda, F, Bisoffi, A, Bjorkas, C, Blackburn, J, Blackman, K, Blackman, T, Blatchford, P, Boboc, A, Bodnar, G, Bolshakova, I, Bonanomi, N, Bonelli, F, Boom, J, Booth, J, Borba, D, Borodin, D, Borodkina, I, Boulting, P, Bowden, M, Bower, C, Bowman, C, Boyce, T, Boyd, C, Boyer, H, Bradshaw, J, Braic, V, Bravanec, R, Breizman, B, Brennan, P, Breton, S, Brett, A, Bright, M, Brix, M, Broeckx, W, Brombin, M, Broslawski, A, Brown, D, Brown, M, Bruno, E, Bucalossi, J, Buch, J, Buckley, M, Budny, R, Bulman, M, Bulmer, N, Bunting, P, Buscarino, A, Busse, A, Butler, N, Bykov, I, Byrne, J, Calvo, I, Camp, P, Campling, D, Cane, J, Capel, A, Card, P, Carman, P, Carraro, L, Carvalho, B, Carvalho, I, Casson, F, Catarino, N, Caumont, J, Cave-Ayland, K, Cavinato, M, Cecil, E, Cenedese, A, Chandler, M, Chandra, D, Chang, C, Chitarin, G, Ciric, D, Clark, E, Clark, M, Clarkson, R, Clatworthy, D, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Cocilovo, V, Coffey, I, Collins, S, Conka, D, Conroy, S, Conway, N, Coombs, D, Cooper, D, Cooper, S, Corradino, C, Corrigan, G, Cortes, S, Couchman, A, Cox, M, Craciunescu, T, Cramp, S, Craven, R, Croft, D, Crombe, K, Crowe, R, Cufar, A, Cullen, A, Curuia, M, Dabirikhah, H, Dalgliesh, P, Dalley, S, Dankowski, J, Darrow, D, Davies, O, Davis, W, Day, I, De Bock, M, de Castro, A, de la Cal, E, de la Luna, E, de Pablos, J, de Vries, P, Deakin, K, Deane, J, Degli Agostini, F, Dejarnac, R, Delabie, E, den Harder, N, Denis, J, Devaux, S, Devynck, P, Di Maio, F, Dinca, P, Ding, B, Dittmar, T, Doerk, H, Doerner, R, Donne, T, Dorling, S, Dormido-Canto, S, Doswon, S, Doyle, P, Drewelow, P, Drews, P, Duckworth, P, Dumont, R, Dumortier, P, Duran, I, Durodie, F, Dutta, P, Dylst, K, Dzysiuk, N, Edappala, P, Edmond, J, Edwards, A, Edwards, J, Ekedahl, A, El-Jorf, R, Elsmore, C, Enachescu, M, Ericsson, G, Eriksson, F, Eriksson, J, Eriksson, L, Esquembri, S, Esser, H, Esteve, D, Evans, B, Evans, G, Evison, G, Ewart, G, Fagan, D, Falie, D, Fasoli, A, Faustin, J, Fawlk, N, Fazendeiro, L, Felton, R, Fenton, K, Fernades, A, Fernandes, H, Fessey, J, Field, A, Figueiredo, J, Finburg, P, Firdaouss, M, Fischer, U, Fittill, L, Flammini, D, Flanagan, J, Fleming, C, Flinders, K, Fonnesu, N, Fontdecaba, J, Formisano, A, Forsythe, L, Fortuna, L, Fortuna-Zalesna, E, Fortune, M, Foster, S, Franke, T, Franklin, T, Frasca, M, Freisinger, M, Fresa, R, Fuchs, V, Fuller, D, Fyvie, J, Gal, K, Galassi, D, Gallagher, J, Galvao, R, Gao, X, Gaudio, P, Gear, D, Gee, S, Gelfusa, M, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Ghate, M, Gherendi, M, Giacalone, J, Gibson, C, Giegerich, T, Gil, C, Gil, L, Gilligan, S, Gin, D, Girardo, J, Giruzzi, G, Godwin, J, Goff, J, Gohil, P, Goloborod'Ko, V, Gomes, R, Goncalves, B, Goniche, M, Goodliffe, M, Goodyear, A, Gosk, M, Goulding, R, Goussarov, A, Gowland, R, Graham, B, Graham, M, Graves, J, Grazier, N, Grazier, P, Green, N, Grierson, B, Griph, F, Grisolia, C, Grist, D, Grove, R, Grundy, C, Grzonka, J, Guard, D, Guerard, C, Guillemaut, C, Gurl, C, Utoh, H, Hackett, L, Hagar, A, Hager, R, Halitovs, M, Hallworth Cook, S, Hamlyn-Harris, C, Hammond, K, Harrington, C, Hasenbeck, F, Hatano, Y, Haupt, T, Hawes, J, Hawkes, N, Hawkins, J, Hawkins, P, Haydon, P, Hayter, N, Hazel, S, Heesterman, P, Heinola, K, Hellesen, C, Hemming, O, Hender, T, Henderson, M, Henriques, R, Hepple, D, Hermon, G, Hertout, P, Hidalgo, C, Highcock, E, Hill, M, Hillairet, J, Hillesheim, J, Hillis, D, Hizanidis, K, Hjalmarsson, A, Hodille, E, Hogben, C, Hogeweij, G, Hollingsworth, A, Hollis, S, Homfray, D, Horton, A, Horton, L, Hotchin, S, Hough, M, Howarth, P, Hubbard, A, Huber, V, Huddleston, T, Hughes, M, Huijsmans, G, Hunter, C, Huynh, P, Hynes, A, Iglesias, D, Imazawa, N, Imbeaux, F, Incelli, M, Irishkin, M, Jachmich, S, Jansons, J, Jarvinen, A, Jednorog, S, Jenkins, I, Jeong, C, Jepu, I, Johnson, R, Johnson, T, Johnston, J, Joita, L, Jones, G, Jones, T, Hoshino, K, Kamiya, K, Kaniewski, J, Kantor, A, Karkinsky, D, Karnowska, I, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, D, Keenan, T, Keep, J, Kempenaars, M, Kennedy, C, Kenny, D, Kent, J, Kent, O, Khilkevich, E, Kim, H, Kinch, A, King, C, King, D, King, R, Kinna, D, Kiptily, V, Kirov, K, Kirschner, A, Kizane, G, Klepper, C, Klix, A, Knight, P, Knipe, S, Knott, S, Kobuchi, T, Koechl, F, Kodeli, I, Kogan, L, Koivuranta, S, Kominis, Y, Koeppen, M, Kos, B, Koskela, T, Kovari, M, Kowalska-Strzeciwilk, E, Krasilnikov, A, Krasilnikov, V, Kresina, M, Kruezi, U, Ksiazek, I, Kukushkin, A, Kundu, A, Kwak, S, Kwiatkowski, R, Kwon, O, Laing, A, Lam, N, Lambertz, H, Lane, C, Lanthaler, S, Lapins, J, Lasa, A, Last, J, Laszynska, E, Lawless, R, Lawson, A, Lawson, K, Lazzaro, E, Lee, S, Lefebvre, X, Leggate, H, Lehmann, J, Leichtle, D, Leichuer, P, Lengar, I, Lennholm, M, Lerche, E, Lescinskis, A, Lesnoj, S, Letellier, E, Leysen, W, Likonen, J, Linke, J, Linsmeier, C, Liu, G, Lo Schiavo, V, Lobel, R, Lomas, P, Lonnroth, J, Lopez, J, Lopez-Razola, J, Lorenzini, R, Losada, U, Lovell, J, Loving, A, Lowry, C, Luce, T, Lucock, R, Lukin, A, Luna, C, Lungaroni, M, Lungu, C, Lungu, M, Lunniss, A, Macdonald, N, Macheta, P, Maczewa, K, Magesh, B, Makkonen, T, Makwana, R, Malaquias, A, Malizia, A, Manning, A, Manzanares, A, Maquet, P, Marandet, Y, Marcenko, N, Marchetto, C, Marchuk, O, Marinelli, M, Marot, L, Marren, C, Marshal, R, Martin de Aguilera, A, Martinez, F, Martin-Solis, J, Martynova, Y, Maruyama, S, Masiello, A, Maslov, M, Matejcik, S, Maviglia, F, May-Smith, T, Mazzotta, C, Mccormack, O, Mccullen, P, Mcdonald, D, Mcintosh, S, Mckean, R, Mckehon, J, Meadows, R, Meakins, A, Medina, F, Medland, M, 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B., Giruzzi G., Godwin J., Goff J., Gohil P., Goloborod'ko V., Gomes R., Goncalves B., Goniche M., Goodliffe M., Goodyear A., Gosk M., Goulding R., Goussarov A., Gowland R., Graham B., Graham M. E., Graves J. P., Grazier N., Grazier P., Green N. R., Grierson B., Griph F. S., Grisolia C., Grist D., Grove R., Grundy C. N., Grzonka J., Guard D., Guerard C., Guillemaut C., Gurl C., Utoh H. H., Hackett L. J., Hagar A., Hager R., Halitovs M., Hall S. J., Hallworth Cook S. P., Hamlyn-Harris C., Hammond K., Harrington C., Hasenbeck F., Hatano Y., Hatch D. R., Haupt T. D. V., Hawes J., Hawkes N. C., Hawkins J., Hawkins P., Haydon P. W., Hayter N., Hazel S., Heesterman P. J. L., Heinola K., Hellesen C., Hemming O. N., Hender T. C., Henderson M., Henderson S. S., Henriques R., Hepple D., Hermon G., Hertout P., Hidalgo C., Highcock E. G., Hill M., Hillairet J., Hillesheim J., Hillis D., Hizanidis K., Hjalmarsson A., Hodille E., Hogben C. H. A., Hogeweij G. M. D., Hollingsworth A., Hollis S., Homfray D. A., Horton A. R., Horton L. D., Hotchin S. P., Hough M. R., Howarth P. J., Hubbard A., Huber V., Huddleston T. M., Hughes M., Huijsmans G. T. A., Hunter C. L., Huynh P., Hynes A. M., Iglesias D., Imazawa N., Imbeaux F., Incelli M., Irishkin M., Jachmich S., Jansons J., Jarvinen A., Jednorog S., Jenkins I., Jeong C., Jepu I., Johnson R., Johnson T., Johnston J., Joita L., Jones G., Jones T. T. C., Hoshino K. K., Kamiya K., Kaniewski J., Kantor A., Karkinsky D., Karnowska I., Kaufman M., Kaveney G., Kazakov Y., Kazantzidis V., Keeling D. L., Keenan T., Keep J., Kempenaars M., Kennedy C., Kenny D., Kent J., Kent O. N., Khilkevich E., Kim H. T., Kim H. S., Kinch A., King C., King D., King R. F., Kinna D. J., Kiptily V., Kirov K., Kirschner A., Kizane G., Klepper C., Klix A., Knight P., Knipe S. 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- Abstract
The aim of this paper is to present a signal processing algorithm that, applied to the raw Locked Mode signal, allows us to obtain a disruption indicator in principle exploitable on different tokamaks. A common definition of such an indicator for different machines would facilitate the development of portable systems for disruption prediction, which is becoming of increasingly importance for the next tokamak generations. Moreover, the indicator allows us to overcome some intrinsic problems in the diagnostic system such as drift and offset. The behavior of the proposed indicator as disruption predictor, based on crossing optimized thresholds of the signal amplitude, has been analyzed using data of both JET and ASDEX Upgrade experiments. A thorough analysis of the disruption prediction performance shows how the indicator is able to recover some missed and tardy detections of the raw signal. Moreover, it intervenes and corrects premature or even wrong alarms due to, e.g., drifts and/or offsets.
- Published
- 2019
5. A locked mode indicator for disruption prediction on JET and ASDEX upgrade
- Author
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Sias, G., Cannas, B., Fanni, A., Murari, A., Pau, A., Kallenbach, A., Aguiam, D., Aho-Mantila, L., Angioni, C., Arden, N., Arredondo Parra, R., Asunta, O., de Baar, M., Balden, M., Behler, K., Bergmann, A., Bernardo, J., Bernert, M., Beurskens, M., Biancalani, A., Bilato, R., Birkenmeier, G., Bobkov, V., Bock, A., Bogomolov, A., Bolzonella, T., Boeswirth, B., Bottereau, C., Bottino, A., van den Brand, H., Brezinsek, S., Brida, D., Brochard, F., Bruhn, C., Buchanan, J., Buhler, A., Burckhart, A., Cambon-Silva, D., Camenen, Y., Carvalho, P., Carrasco, G., Cazzaniga, C., Carr, M., Carralero, D., Casali, L., Castaldo, C., Cavedon, M., Challis, C., Chankin, A., Chapman, I., Clairet, F., Classen, I., Coda, S., Coelho, R., Coenen, J. W., Colas, L., Conway, G., Costea, S., Coster, D. P., Croci, G., Cseh, G., Czarnecka, A., D'Arcangelo, O., Day, C., Delogu, R., de Marne, P., Denk, S., Denner, P., Dibon, M., D'Inca, R., Di Siena, A., Douai, D., Drenik, A., Drube, R., Dunne, M., Duval, B. P., Dux, R., Eich, T., Elgeti, S., Engelhardt, K., Erdos, B., Erofeev, I., Esposito, B., Fable, E., Faitsch, M., Fantz, U., Faugel, H., Felici, F., Fietz, S., Figueredo, A., Fischer, R., Ford, O., Frassinetti, L., Freethy, S., Froeschle, M., Fuchert, G., Fuchs, J. C., Fuenfgelder, H., Galazka, K., Galdon-Quiroga, J., Gallo, A., Gao, Y., Garavaglia, S., Garcia-Munoz, M., Geiger, B., Cianfarani, C., Giannone, L., Giovannozzi, E., Gleason-Gonzalez, C., Gloeggler, S., Gobbin, M., Goerler, T., Goodman, T., Gorini, G., Gradic, D., Graeter, A., Granucci, G., Greuner, H., Griener, M., Groth, M., Gude, A., Guenter, S., Guimarais, L., Haas, G., Hakola, A. H., Ham, C., Happel, T., Harrison, J., Hatch, D., Hauer, V., Hayward, T., Heinemann, B., Heinzel, S., Hellsten, T., Henderson, S., Hennequin, P., Herrmann, A., Heyn, E., Hitzler, F., Hobirk, J., Hoelzl, M., Hoeschen, T., Holm, J. H., Hopf, C., Hoppe, F., Horvath, L., Houben, A., Huber, A., Igochine, V., Ilkei, T., Ivanova-Stanik, I., Jacob, W., Jacobsen, A. S., Jacquot, J., Janky, F., Jardin, A., Jaulmes, F., Jenko, F., Jensen, T., Joffrin, E., Kasemann, C., Kalvin, S., Kantor, M., Kappatou, A., Kardaun, O., Karhunen, J., Kasilov, S., Kernbichler, W., Kim, D., Kimmig, S., Kirk, A., Klingshirn, H. J., Koch, F., Kocsis, G., Koehn, A., Kraus, M., Krieger, K., Krivska, A., Kraemer-Flecken, A., Kurki-Suonio, T., Kurzan, B., Lackner, K., Laggner, F., Lang, P. T., Lauber, P., Lazanyi, N., Lazaros, A., Lebschy, A., Li, L., Li, M., Liang, Y., Lipschultz, B., Liu, Y., Lohs, A., Luhmann, N. C., Lunt, T., Lyssoivan, A., Madsen, J., Maier, H., Maj, O., Mailloux, J., Maljaars, E., Manas, P., Mancini, A., Manhard, A., Manso, M. E., Mantica, P., Mantsinen, M., Manz, P., Maraschek, M., Martens, C., Martin, P., Marrelli, L., Martitsch, A., Mastrostefano, S., Mayer, A., Mayer, M., Mazon, D., Mccarthy, P. J., Mcdermott, R., Meisl, G., Meister, H., Medvedeva, A., Merkel, P., Merkel, R., Merle, A., Mertens, V., Meshcheriakov, D., Meyer, H., Meyer, O., Miettunen, J., Milanesio, D., Mink, F., Mlynek, A., Monaco, F., Moon, C., Nazikian, R., Nemes-Czopf, A., Neu, G., Neu, R., Nielsen, A. H., Nielsen, S. K., Nikolaeva, V., Nocente, M., Noterdaeme, J. 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C., Siren, P., Sirinelli, A., Sjostrand, H., Skiba, M., Skilton, R., Slabkowska, K., Slade, B., Smith, N., Smith, P. G., Smith, R., Smith, T. J., Smithies, M., Snoj, L., Soare, S., Solano, E. R., Somers, A., Sonato, P., Sopplesa, A., Sousa, J., Spelzini, T., Spineanu, F., Stables, G., Stamatelatos, I., Stamp, M. F., Staniec, P., Stankunas, G., Stan-Sion, C., Stead, M. J., Stefanikova, E., Stephen, A. V., Stephen, M., Stevens, A., Stevens, B. D., Strachan, J., Strauss, H. R., Strom, P., Stubbs, G., Studholme, W., Subba, F., Summers, H. P., Svensson, J., Swiderski, L., Szabolics, T., Szawlowski, M., Szepesi, G., Suzuki, T. T., Talbot, A. R., Talebzadeh, S., Taliercio, C., Tame, C., Tang, W., Taroni, L., Taylor, D., Taylor, K. A., Tegnered, D., Telesca, G., Teplova, N., Tholerus, E., Thomas, J., Thomas, J. D., Thomas, P., Thompson, A., Thompson, C. A., Thompson, V. K., Thorne, L., Thrysoe, A. S., Tigwell, P. A., Tipton, N., Tiseanu, I., Tojo, H., Tokitani, M., Tomes, M., Tonner, P., Towndrow, M., Trimble, P., Tsalas, M., Tsavalas, P., Tskhakaya Jun, D., Turner, I., Turner, M. M., Turnyanskiy, M., Tvalashvili, G., Tyrrell, S. G. J., Ul-Abidin, Z., Uljanovs, J., Ulyatt, D., Urano, H., Uytdenhouwen, I., Vadgama, A. P., Valcarcel, D., Valentinuzzi, M., Vallejos Olivares, P., Van De Mortel, M., Van Eester, D., Van Renterghem, W., van Rooij, G. J., Varje, J., Vasava, K., Vasilopoulou, T., Verhoeven, R., Verona, C., Verona Rinati, G., Veshchev, E., Villari, S., Vincenzi, P., Vinyar, I., Vitins, A., Vizvary, Z., Vlad, M., Vora, N., Vu, T., Pires de Sa, W. W., Wakeling, B., Waldon, C. W. F., Walker, M., Walker, R., Walsh, M., Wang, E., Warder, S., Warren, R. J., Waterhouse, J., Watkins, N. W., Watts, C., Weckmann, A., Weiland, J., Weisen, H., Weiszflog, M., Wellstood, C., West, A. T., Wheatley, M. R., Whetham, S., Whitehead, A. M., Whitehead, B. D., Widdowson, A. 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A., Reynolds, S., Riccardo, V., Richardson, N., Riddle, K., Rigamonti, D., Rimini, F. G., Risner, J., Riva, M., Roach, C., Robins, R. J., Robinson, S. A., Robinson, T., Robson, D. W., Roccella, R., Rodionov, R., Rodrigues, P., Rodriguez, J., Romanelli, F., Romanelli, M., Romanelli, S., Romazanov, J., Rowe, S., Rubinacci, G., Rubino, G., Ruchko, L., Ruiz, M., Ruset, C., Rzadkiewicz, J., Safi, E., Sagar, P., Saibene, G., Salmon, R., Salzedas, F., Samm, U., Sandiford, D., Santa, P., Santala, M. I. K., Santos, B., Santucci, A., Sartori, F., Sartori, R., Schlummer, T., Schmidt, V., Schmuck, S., Schoepf, K., Schworer, D., Scott, S. D., Sergienko, G., Sharapov, S. E., Shaw, A., Shaw, R., Sheikh, H., Shepherd, A., Shevelev, A., Shumack, A., Sibbald, M., Silburn, S., Simmons, P. A., Simpson-Hutchinson, J., Sinha, A., Sipila, S. K., Sips, A. C. C., Siren, P., Sirinelli, A., Sjostrand, H., Skiba, M., Skilton, R., Slabkowska, K., Slade, B., Smith, N., Smith, P. G., Smith, R., Smith, T. 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D., Zerbini, M., Zhou, Y., Zilli, E., Zoita, V., Zychor, I., ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society, EUROfusion MST1 Team, JET Contributors, Sias, G, Cannas, B, Fanni, A, Murari, A, Pau, A, Kallenbach, A, Aguiam, D, Aho-Mantila, L, Angioni, C, Arden, N, Arredondo Parra, R, Asunta, O, de Baar, M, Balden, M, Behler, K, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boeswirth, B, Bottereau, C, Bottino, A, van den Brand, H, Brezinsek, S, Brida, D, Brochard, F, Bruhn, C, Buchanan, J, Buhler, A, Burckhart, A, Cambon-Silva, D, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carr, M, Carralero, D, Casali, L, Castaldo, C, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, D'Arcangelo, O, Day, C, Delogu, R, de Marne, P, Denk, S, 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Sheikh, U, Silva Fuglister, M, Spagnolo, S, Spizzo, G, Stange, T, Stejner Pedersen, M, Stepanov, I, Strand, P, Susnjara, A, Tamain, P, Teplukhina, A, Testa, D, Theiler, C, Thornton, A, Tolias, P, Tophoj, L, Tsironis, C, Tsui, C, Uccello, A, Urban, J, Vallejos, P, Vartanian, S, Vega, J, Verhaegh, K, Vermare, L, Vignitchouk, L, Vijvers, W, Villone, F, Viola, B, Vlahos, L, Voitsekhovitch, I, Vondracek, P, Vu, N, Walkden, N, Wauters, T, Weinzettl, V, Westerhof, E, Wiesenberger, M, Wodniak, I, Yadykin, D, Zanca, P, Zaplotnik, R, Zestanakis, P, Zuin, M, Litaudon, X, Abduallev, S, Abhangi, M, Abreu, P, Afzal, M, Aggarwal, K, Ahlgren, T, Aiba, N, Airila, M, Aldred, V, Alegre, D, Aleynikov, P, Alfier, A, Alkseev, A, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Amosov, V, Andersson Sunden, E, Angelone, M, Anghel, M, Appel, L, Appelbee, C, Arena, P, Arshad, S, Ash, A, Ashikawa, N, Aslanyan, V, Auriemma, F, Austin, Y, Avotina, L, Axton, M, Ayres, C, Bacharis, M, Baiao, D, Bailey, S, Baker, A, Balboa, I, Balshaw, N, Bament, R, Banks, J, Baranov, Y, Barnard, M, Barnes, D, Barnsley, R, Baron Wiechec, A, Barrera Orte, L, Baruzzo, M, Basiuk, V, Bassan, M, Bastow, R, Batista, A, Batistoni, P, Baughan, R, Bauvir, B, Baylor, L, Bazylev, B, Beal, J, Beaumont, P, Beckers, M, Beckett, B, Becoulet, A, Bekris, N, Beldishevski, M, Bell, K, Belli, F, Bellinger, M, Belonohy, E, Ben Ayed, N, Benterman, N, Bergsaker, H, Berry, M, Bertalot, L, Besliu, C, Bieg, B, Bielecki, J, Biewer, T, Bigi, M, Binda, F, Bisoffi, A, Bjorkas, C, Blackburn, J, Blackman, K, Blackman, T, Blatchford, P, Boboc, A, Bodnar, G, Bolshakova, I, Bonanomi, N, Bonelli, F, Boom, J, Booth, J, Borba, D, Borodin, D, Borodkina, I, Boulting, P, Bowden, M, Bower, C, Bowman, C, Boyce, T, Boyd, C, Boyer, H, Bradshaw, J, Braic, V, Bravanec, R, Breizman, B, Brennan, P, Breton, S, Brett, A, Bright, M, Brix, M, Broeckx, W, Brombin, M, Broslawski, A, Brown, D, Brown, M, Bruno, E, Bucalossi, J, Buch, J, Buckley, M, Budny, R, Bulman, M, Bulmer, N, Bunting, P, Buscarino, A, Busse, A, Butler, N, Bykov, I, Byrne, J, Calvo, I, Camp, P, Campling, D, Cane, J, Capel, A, Card, P, Carman, P, Carraro, L, Carvalho, B, Carvalho, I, Casson, F, Catarino, N, Caumont, J, Cave-Ayland, K, Cavinato, M, Cecil, E, Cenedese, A, Chandler, M, Chandra, D, Chang, C, Chitarin, G, Ciric, D, Clark, E, Clark, M, Clarkson, R, Clatworthy, D, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Cocilovo, V, Coffey, I, Collins, S, Conka, D, Conroy, S, Conway, N, Coombs, D, Cooper, D, Cooper, S, Corradino, C, Corrigan, G, Cortes, S, Couchman, A, Cox, M, Craciunescu, T, Cramp, S, Craven, R, Croft, D, Crombe, K, Crowe, R, Cufar, A, Cullen, A, Curuia, M, Dabirikhah, H, Dalgliesh, P, Dalley, S, Dankowski, J, Darrow, D, Davies, O, Davis, W, Day, I, De Bock, M, de Castro, A, de la Cal, E, de la Luna, E, de Pablos, J, de Vries, P, Deakin, K, Deane, J, Degli Agostini, F, Dejarnac, R, Delabie, E, den Harder, N, Denis, J, Devaux, S, Devynck, P, Di Maio, F, Dinca, P, Ding, B, Dittmar, T, Doerk, H, Doerner, R, Donne, T, Dorling, S, Dormido-Canto, S, Doswon, S, Doyle, P, Drewelow, P, Drews, P, Duckworth, P, Dumont, R, Dumortier, P, Duran, I, Durodie, F, Dutta, P, Dylst, K, Dzysiuk, N, Edappala, P, Edmond, J, Edwards, A, Edwards, J, Ekedahl, A, El-Jorf, R, Elsmore, C, Enachescu, M, Ericsson, G, Eriksson, F, Eriksson, J, Eriksson, L, Esquembri, S, Esser, H, Esteve, D, Evans, B, Evans, G, Evison, G, Ewart, G, Fagan, D, Falie, D, Fasoli, A, Faustin, J, Fawlk, N, Fazendeiro, L, Felton, R, Fenton, K, Fernades, A, Fernandes, H, Fessey, J, Field, A, Figueiredo, J, Finburg, P, Firdaouss, M, Fischer, U, Fittill, L, Flammini, D, Flanagan, J, Fleming, C, Flinders, K, Fonnesu, N, Fontdecaba, J, Formisano, A, Forsythe, L, Fortuna, L, Fortuna-Zalesna, E, Fortune, M, Foster, S, Franke, T, Franklin, T, Frasca, M, Freisinger, M, Fresa, R, Fuchs, V, Fuller, D, Fyvie, J, Gal, K, Galassi, D, Gallagher, J, Galvao, R, Gao, X, Gaudio, P, Gear, D, Gee, S, Gelfusa, M, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Ghate, M, Gherendi, M, Giacalone, J, Gibson, C, Giegerich, T, Gil, C, Gil, L, Gilligan, S, Gin, D, Girardo, J, Giruzzi, G, Godwin, J, Goff, J, Gohil, P, Goloborod'Ko, V, Gomes, R, Goncalves, B, Goniche, M, Goodliffe, M, Goodyear, A, Gosk, M, Goulding, R, Goussarov, A, Gowland, R, Graham, B, Graham, M, Graves, J, Grazier, N, Grazier, P, Green, N, Grierson, B, Griph, F, Grisolia, C, Grist, D, Grove, R, Grundy, C, Grzonka, J, Guard, D, Guerard, C, Guillemaut, C, Gurl, C, Utoh, H, Hackett, L, Hagar, A, Hager, R, Halitovs, M, Hallworth Cook, S, Hamlyn-Harris, C, Hammond, K, Harrington, C, Hasenbeck, F, Hatano, Y, Haupt, T, Hawes, J, Hawkes, N, Hawkins, J, Hawkins, P, Haydon, P, Hayter, N, Hazel, S, Heesterman, P, Heinola, K, Hellesen, C, Hemming, O, Hender, T, Henderson, M, Henriques, R, Hepple, D, Hermon, G, Hertout, P, Hidalgo, C, Highcock, E, Hill, M, Hillairet, J, Hillesheim, J, Hillis, D, Hizanidis, K, Hjalmarsson, A, Hodille, E, Hogben, C, Hogeweij, G, Hollingsworth, A, Hollis, S, Homfray, D, Horton, A, Horton, L, Hotchin, S, Hough, M, Howarth, P, Hubbard, A, Huber, V, Huddleston, T, Hughes, M, Huijsmans, G, Hunter, C, Huynh, P, Hynes, A, Iglesias, D, Imazawa, N, Imbeaux, F, Incelli, M, Irishkin, M, Jachmich, S, Jansons, J, Jarvinen, A, Jednorog, S, Jenkins, I, Jeong, C, Jepu, I, Johnson, R, Johnson, T, Johnston, J, Joita, L, Jones, G, Jones, T, Hoshino, K, Kamiya, K, Kaniewski, J, Kantor, A, Karkinsky, D, Karnowska, I, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, D, Keenan, T, Keep, J, Kempenaars, M, Kennedy, C, Kenny, D, Kent, J, Kent, O, Khilkevich, E, Kim, H, Kinch, A, King, C, King, D, King, R, Kinna, D, Kiptily, V, Kirov, K, Kirschner, A, Kizane, G, Klepper, C, Klix, A, Knight, P, Knipe, S, Knott, S, Kobuchi, T, Koechl, F, Kodeli, I, Kogan, L, Koivuranta, S, Kominis, Y, Koeppen, M, Kos, B, Koskela, T, Kovari, M, Kowalska-Strzeciwilk, E, Krasilnikov, A, Krasilnikov, V, Kresina, M, Kruezi, U, Ksiazek, I, Kukushkin, A, Kundu, A, Kwak, S, Kwiatkowski, R, Kwon, O, Laing, A, Lam, N, Lambertz, H, Lane, C, Lanthaler, S, Lapins, J, Lasa, A, Last, J, Laszynska, E, Lawless, R, Lawson, A, Lawson, K, Lazzaro, E, Lee, S, Lefebvre, X, Leggate, H, Lehmann, J, Leichtle, D, Leichuer, P, Lengar, I, Lennholm, M, Lerche, E, Lescinskis, A, Lesnoj, S, Letellier, E, Leysen, W, Likonen, J, Linke, J, Linsmeier, C, Liu, G, Lo Schiavo, V, Lobel, R, Lomas, P, Lonnroth, J, Lopez, J, Lopez-Razola, J, Lorenzini, R, Losada, U, Lovell, J, Loving, A, Lowry, C, Luce, T, Lucock, R, Lukin, A, Luna, C, Lungaroni, M, Lungu, C, Lungu, M, Lunniss, A, Macdonald, N, Macheta, P, Maczewa, K, Magesh, B, Makkonen, T, Makwana, R, Malaquias, A, Malizia, A, Manning, A, Manzanares, A, Maquet, P, Marandet, Y, Marcenko, N, Marchetto, C, Marchuk, O, Marinelli, M, Marot, L, Marren, C, Marshal, R, Martin de Aguilera, A, Martinez, F, Martin-Solis, J, Martynova, Y, Maruyama, S, Masiello, A, Maslov, M, Matejcik, S, Maviglia, F, May-Smith, T, Mazzotta, C, Mccormack, O, Mccullen, P, Mcdonald, D, Mcintosh, S, Mckean, R, Mckehon, J, Meadows, R, Meakins, A, Medina, F, Medland, M, Medley, S, Meigh, S, Meigs, A, Meitner, S, Meneses, L, Menmuir, S, Mergia, K, Merrigan, I, Mertens, P, Meshchaninov, S, Messiaen, A, Mianowski, S, Michling, R, Middleton-Gear, D, Militello-Asp, E, Miloshevsky, G, Minucci, S, Miyoshi, Y, Moneti, M, Mooney, R, Moradi, S, Mordijck, S, Moreira, L, Moreno, R, Moro, F, Morris, A, Morris, J, Moser, L, Mosher, S, Muraro, A, Murphy, S, Asakura, N, Na, Y, Naish, R, Nakano, T, Nave, M, Nedzelski, I, Nemtsev, G, Neto, A, Neverov, V, Newman, M, Nicholls, K, Nicolas, T, Nielsen, P, Nilsson, E, Nishijima, D, Noble, C, Nodwell, D, Nordlund, K, Nordman, H, Nunes, I, Odupitan, T, Ogawa, M, O'Gorman, T, Okabayashi, M, Olney, R, Omolayo, O, Ongena, J, Orsitto, F, Orszagh, J, Oswuigwe, B, Otin, R, Owen, A, Pace, N, Pacella, D, Packer, L, Page, A, Pajuste, E, Palazzo, S, Panja, S, Papp, P, Park, M, Parra Diaz, F, Parsons, M, Pasqualotto, R, Patel, A, Pathak, S, Paton, D, Patten, H, Pawelec, E, Paz Soldan, C, Peackoc, A, Pearson, I, Peluso, E, Penot, C, Pereira, R, Pereira Puglia, P, Perez von Thun, C, Peruzzo, S, Peschanyi, S, Petravich, G, Petre, A, Petrella, N, Peysson, Y, Pfefferle, D, Philipps, V, Pillon, M, Pintsuk, G, Pires dos Reis, A, Piron, L, Pizzo, F, Pomaro, N, Pompilian, O, Pool, P, Popovichev, S, Porfiri, M, Porosnicu, C, Porton, M, Possnert, G, Powell, T, Pozzi, J, Prajapati, V, Prakash, R, Prestopino, G, Price, D, Price, M, Price, R, Prior, P, Proudfoot, R, Puglia, P, Pulley, D, Purahoo, K, Rachlew, E, Ragona, R, Rainford, M, Rakha, A, Ranjan, S, Rathod, K, Rayner, C, Rebai, M, Reece, D, Reed, A, Regan, B, Regana, J, Reid, N, Reinhart, M, Rendell, D, Reyes Cortes, S, Reynolds, S, Riccardo, V, Richardson, N, Riddle, K, Rigamonti, D, Rimini, F, Risner, J, Riva, M, Roach, C, Robins, R, Robinson, S, Robinson, T, Robson, D, Roccella, R, Rodionov, R, Rodrigues, P, Rodriguez, J, Romanelli, F, Romanelli, M, Romanelli, S, Romazanov, J, Rowe, S, Rubinacci, G, Rubino, G, Ruchko, L, Ruiz, M, Ruset, C, Rzadkiewicz, J, Safi, E, Sagar, P, Saibene, G, Salmon, R, Salzedas, F, Samm, U, Sandiford, D, Santa, P, Santala, M, Santos, B, Santucci, A, Sartori, F, Sartori, R, Schlummer, T, Schmidt, V, Schmuck, S, Schoepf, K, Schworer, D, Scott, S, Sergienko, G, Shaw, A, Shaw, R, Sheikh, H, Shepherd, A, Shevelev, A, Shumack, A, Sibbald, M, Silburn, S, Simmons, P, Simpson-Hutchinson, J, Sinha, A, Sipila, S, Sips, A, Siren, P, Sirinelli, A, Sjostrand, H, Skiba, M, Skilton, R, Slabkowska, K, Slade, B, Smith, N, Smith, P, Smith, R, Smith, T, Smithies, M, Snoj, L, Soare, S, Solano, E, Somers, A, Sonato, P, Sopplesa, A, Sousa, J, Spelzini, T, Spineanu, F, Stables, G, Stamatelatos, I, Stamp, M, Staniec, P, Stankunas, G, Stan-Sion, C, Stead, M, Stefanikova, E, Stephen, A, Stephen, M, Stevens, A, Stevens, B, Strachan, J, Strauss, H, Strom, P, Stubbs, G, Studholme, W, Subba, F, Summers, H, Svensson, J, Swiderski, L, Szabolics, T, Szawlowski, M, Szepesi, G, Suzuki, T, Talbot, A, Talebzadeh, S, Taliercio, C, Tame, C, Tang, W, Taroni, L, Taylor, D, Taylor, K, Tegnered, D, Telesca, G, Teplova, N, Tholerus, E, Thomas, J, Thomas, P, Thompson, A, Thompson, C, Thompson, V, Thorne, L, Thrysoe, A, Tigwell, P, Tipton, N, Tiseanu, I, Tojo, H, Tokitani, M, Tomes, M, Tonner, P, Towndrow, M, Trimble, P, Tsalas, M, Tsavalas, P, Tskhakaya Jun, D, Turner, I, Turner, M, Turnyanskiy, M, Tvalashvili, G, Tyrrell, S, Ul-Abidin, Z, Uljanovs, J, Ulyatt, D, Urano, H, Uytdenhouwen, I, Vadgama, A, Valcarcel, D, Valentinuzzi, M, Vallejos Olivares, P, Van De Mortel, M, Van Eester, D, Van Renterghem, W, van Rooij, G, Varje, J, Vasava, K, Vasilopoulou, T, Verhoeven, R, Verona, C, Verona Rinati, G, Veshchev, E, Villari, S, Vincenzi, P, Vinyar, I, Vitins, A, Vizvary, Z, Vlad, M, Vora, N, Vu, T, Pires de Sa, W, Wakeling, B, Waldon, C, Walker, M, Walker, R, Walsh, M, Wang, E, Warder, S, Warren, R, Waterhouse, J, Watkins, N, Watts, C, Weckmann, A, Weiland, J, Weisen, H, Weiszflog, M, Wellstood, C, West, A, Wheatley, M, Whetham, S, Whitehead, A, Whitehead, B, Widdowson, A, Wiesen, S, Wilkinson, J, Williams, J, Williams, M, Wilson, A, Wilson, D, Wilson, H, Wilson, J, Withenshaw, G, Withycombe, A, Witts, D, Wood, D, Wood, R, Woodley, C, Wray, S, Wright, J, Wu, J, Wukitch, S, Wynn, A, Xu, T, Yadikin, D, Yanling, W, Yao, L, Yavorskij, V, Yoo, M, Young, C, Young, D, Young, I, Young, R, Zacks, J, Zaitsev, F, Zanino, R, Zarins, A, Zastrow, K, Zerbini, M, Zhou, Y, Zilli, E, Zoita, V, and Zychor, I
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Disruption prediction ,Tokamak ,Offset (computer science) ,Computer science ,Feature extraction ,Disruption indicators ,01 natural sciences ,Signal ,010305 fluids & plasmas ,law.invention ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,ASDEX Upgrade ,law ,Control theory ,0103 physical sciences ,General Materials Science ,010306 general physics ,Locked mode signal ,Civil and Structural Engineering ,Jet (fluid) ,Mechanical Engineering ,[SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment ,Settore FIS/01 - Fisica Sperimentale ,Mode (statistics) ,Amplitude ,Nuclear Energy and Engineering ,Disruption indicator - Abstract
International audience; The aim of this paper is to present a signal processing algorithm that, applied to the raw Locked Mode signal, allows us to obtain a disruption indicator in principle exploitable on different tokamaks. A common definition of such an indicator for different machines would facilitate the development of portable systems for disruption prediction, which is becoming of increasingly importance for the next tokamak generations. Moreover, the indicator allows us to overcome some intrinsic problems in the diagnostic system such as drift and offset. The behavior of the proposed indicator as disruption predictor, based on crossing optimized thresholds of the signal amplitude, has been analyzed using data of both JET and ASDEX Upgrade experiments. A thorough analysis of the disruption prediction performance shows how the indicator is able to recover some missed and tardy detections of the raw signal. Moreover, it intervenes and corrects premature or even wrong alarms due to, e.g., drifts and/or offsets.
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- 2019
6. Vernetzung und Kooperation ehrenamtlicher und akademischer Forschung im Rahmen des nationalen Biodiversitätsmonitorings: Herausforderungen und Lösungsstrategien. Networking and cooperation of voluntary and academic research within the framework of national biodiversity monitoring – challenges and solution strategies
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Sommerwerk, N., Geschke, J., Schliep, R., Esser, J., Glöckler, F., Grossart, H.-P., Hand, R., Kiefer, S., Kimmig, S., Koch, A., Kühn, Elisabeth, Larondelle, N., Lehmann, G., Munzinger, S., Rödl, T., Werner, D., Wessel, M., Vohland, K., Sommerwerk, N., Geschke, J., Schliep, R., Esser, J., Glöckler, F., Grossart, H.-P., Hand, R., Kiefer, S., Kimmig, S., Koch, A., Kühn, Elisabeth, Larondelle, N., Lehmann, G., Munzinger, S., Rödl, T., Werner, D., Wessel, M., and Vohland, K.
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Die systematische Erfassung und Analyse von Biodiversitätsdaten und Ökosystemleistungen ist unerlässlich. Sie trägt zum Verständnis von Ursachen des Biodiversitätsverlusts bei und wird zur Analyse von Trends sowie zur Evaluierung von Interventionsmaßnahmen und politischen Strategien benötigt. Ehrenamtliche Datenerhebungen und wissenschaftliche Analysen spielen bereits seit Jahrzehnten eine tragende Rolle bei der behördlichen Berichterstattung. In diesem Artikel diskutieren wir, welche Schwachstellen und Optimierungsmöglichkeiten dabei in der Zusammenarbeit zwischen ehrenamtlicher und akademischer Forschung existieren. Eine effiziente und vertrauensvolle Zusammenarbeit an dieser Schnittstelle ist von grundlegender Bedeutung, insbesondere, wenn die auf freiwilliger Basis erhobenen Daten in der akademischen Forschung zu Biodiversität und Naturschutz genutzt werden sollen. Wir stellen zentrale Handlungsfelder und konkrete, praxisrelevante Maßnahmen vor, die wesentlich zur Verbesserung dieser Zusammenarbeit und dem Gelingen des nationalen Biodiversitätsmonitorings beitragen können. Dazu gehören ein gemeinsames Verständnis und Koordination des nationalen Biodiversitätsmonitorings, die Bereitstellung von Ressourcen zur Unterstützung nicht akademischer Forschung, Dateninfrastrukturen und Visualisierungstools, aber auch Bildungsanstrengungen zum Beispiel in Vereinen und Schulen. Networking and cooperation of voluntary and academic research within the framework of national biodiversity monitoring – challenges and solution strategies The systematic collection and analysis of biodiversity data and ecosystem services is essential. It contributes to the understanding of the causes of biodiversity loss and is needed to analyse trends and evaluate intervention measures and policies. Data collection by volunteers and scientific analyses have played a key role in government reporting for decades. In this article, we discuss weaknesses in the cooperation between volunteers and formal
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- 2021
7. Biologische Schalter: Das „Alles-oder-Nichts-Prinzip“ der T-Zell-Aktivierung
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Kimmig, S. and Baumgrass, R.
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- 2009
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8. Machine learning goes wild: Using data from captive individuals to infer wildlife behaviour
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Rast, W., primary, Kimmig, S. E., additional, Giese, L., additional, and Berger, A., additional
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- 2019
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9. Fatigue crack initiation in nickel-based superalloys studied by microstructure-based FE modeling and scanning electron microscopy
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Fried M., Krechel C., Affeldt E.E., Eckert B., Kimmig S., Retze U., Höppel H.W., and Göken M.
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Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
In this work stage I crack initiation in polycrystalline nickel-based superalloys is investigated by analyzing anisotropic mechanical properties, local stress concentrations and plastic deformation on the microstructural length scale. The grain structure in the gauge section of fatigue specimens was characterized by EBSD. Based on the measured data, a microstructure-based FE model could be established to simulate the strain and stress distribution in the specimens during the first loading cycle of a fatigue test. The results were in fairly good agreement with experimentally measured local strains. Furthermore, the onset of plastic deformation was predicted by identifying shear stress maxima in the microstructure, presumably leading to activation of slip systems. Measurement of plastic deformation and observation of slip traces in the respective regions of the microstructure confirmed the predicted slip activity. The close relation between micro-plasticity, formation of slip traces and stage I crack initiation was demonstrated by SEM surface analyses of fatigued specimens and an in-situ fatigue test in a large chamber SEM.
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- 2014
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10. A phenotypic marker for thymic activity: De novo recurrence of CD31+CD45RA+: P476
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Schmidt, C. A, Thiel, A., Przybylski, G., Alexander, T., Kimmig, S., Möwes, B., Hiepe, F., Arnold, R., Doelken, G., and Radbruch, A.
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- 2003
11. Citizen science and wildlife biology: Synergies and challenges
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Frigerio, D., Pipek, P., Kimmig, S., Winter, S., Melzheimer, J., Diblíková, L., Wachter, B., Richter, Anett, Frigerio, D., Pipek, P., Kimmig, S., Winter, S., Melzheimer, J., Diblíková, L., Wachter, B., and Richter, Anett
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Citizen science (CS) has evolved over the past decades as a working method involving interested citizens in scientific research, for example by reporting observations, taking measurements or analysing data. In the past, research on animal behaviour has been benefitting from contributions of citizen scientists mainly in the field of ornithology but the full potential of CS in ecological and behavioural sciences is surely still untapped. Here, we present case studies that successfully applied CS to research projects in wildlife biology and discuss potentials and challenges experienced. Our case studies cover a broad range of opportunities: large‐scale CS projects with interactive online tools on bird song dialects, engagement of stakeholders as citizen scientists to reduce human–wildlife conflicts, involvement of students of primary and secondary schools in CS projects as well as collaboration with the media leading to successful recruitment of citizen scientists. Each case study provides a short overview of the scientific questions and how they were approached to showcase the potentials and challenges of CS in wildlife biology. Based on the experience of the case studies, we highlight how CS may support research in wildlife biology and emphasise the value of fostering communication in CS to improve recruitment of participants and to facilitate learning and mutual trust among different groups of interest (e.g., researchers, stakeholders, students). We further show how specific training for the participants may be needed to obtain reliable data. We consider CS as a suitable tool to enhance research in wildlife biology through the application of open science procedures (i.e., open access to articles and the data on publicly available repositories) to support transparency and sharing experiences.
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- 2018
12. Recent ASDEX Upgrade research in support of ITER and DEMO
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Zohm, H, Ahn, J, Aho Mantila, L, Äkäslompolo, S, Angioni, C, Asunta, O, de Baar, M, Balden, M, Barrera Orte, L, Behler, K, Belapure, J, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boom, J, Böswirth, B, Bottereau, C, Bottino, A, van den Brand, H, Braun, F, Brezinsek, S, Brochard, F, Buhler, A, Burckhart, A, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carralero, D, Casali, L, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, CROCI, GABRIELE, Cseh, G, Czarnecka, A, Day, C, de Marné, P, Denner, P, D'Inca, R, Douai, D, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Ertl, K, Esposito, B, Fable, E, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Franzen, P, Frassinetti, L, Fröschle, M, Fuchert, G, Fünfgelder, H, Fuchs, J, Gál, K, Garavaglia, S, Garcia Muñoz, M, Geiger, B, Giannone, L, Giovannozzi, E, Gleason González, C, Görler, T, Goodman, T, GORINI, GIUSEPPE, da Graca, S, Gräter, A, Granucci, G, Greuner, H, Grießhammer, J, Groth, M, Gude, A, Günter, S, Guimarais, L, Haas, G, Hakola, A, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hauff, T, Heinemann, B, Heinzel, S, Hellsten, T, Hennequin, P, Herrmann, A, Heyn, E, Hobirk, J, Hölzl, M, Höschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Jacob, W, Jacobsen, A, Jacquot, J, Janzer, M, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Käsemann, C, Kallenbach, A, Kálvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kim, D, Kimmig, S, Kirk, A, J, Klingshirn, H, Kocan, M, Koch, F, Kocsis, G, Köhn, A, Köppen, M, Kötterl, J, Koslowski, R, Koubiti, M, Kraus, M, Krieger, K, Krivska, A, Kogut, D, Krämer Flecken, A, Kurki Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazányi, N, Lazaros, A, Lebschy, A, Leuterer, F, Liang, Y, Linsmeier, h, Lipschultz, B, Litnovski, A, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Mancini, A, Manhard, A, Mank, K, E, Manso, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Markina, E, Martens, C, Martin, P, Mayer, A, Mayer, M, Mazon, D, McCarthy, P, McDermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Mertens, V, Meyer, H, Meyer, O, Milanesio, D, Miettunen, J, Mlynek, A, Monaco, F, Moro, A, Moseev, D, Müller, H, Müller, S, Münich, M, Nabais, F, Nemes Czopf, A, Neu, G, Neu, R, Nielsen, A, Nikolaeva, V, Nielsen, S, NOCENTE, MASSIMO, Nold, B, M, Noterdaeme, J, Nowak, S, Oberkofler, M, Ochoukov, R, Odstrcil, T, Papp, G, Park, H, Pau, A, Pautasso, G, Penzel, F, Petersson, P, Piovesan, P, Piron, C, Plaum, B, Plöckl, B, Plyusnin, V, Podoba, Y, Pokol, G, Pompon, F, Poli, E, Polozhiy, K, Porte, L, Potzel, S, Preuss, R, Prisiazhniuk, D, Pütterich, T, Ramish, M, Rapson, C, Rasmussen, J, Rathgeber, S, Raupp, G, Réfy, D, Reich, M, Reimold, F, Reinke, M, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez Ramos, M, Rohde, V, Roth, J, Rott, M, Rubel, M, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneider, W, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shalpegin, A, Sias, G, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommer, F, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Sugiyama, K, J, Sun, Suttrop, W, Szepesi, T, Tál, B, Tala, T, Tardini, G, Tichmann, C, Told, D, Tophøj, L, Tudisco, O, von Toussaint, U, Trevisan, G, Treutterer, W, Tripský, M, Valisa, M, Valovic, M, Varela, P, Varoutis, S, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, Vorpahl, C, Wagner, D, Wang, X, Wauters, T, Weidl, I, Weiland, M, Weller, A, Wenninger, R, Wieland, B, Wiesinger, M, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Wünderlich, D, Würsching, E, Yang, Z, Yu, Q, Zammuto, I, Zarzoso, D, Zasche, D, van Zeeland, M, Zehetbauer, T, Zilker, M., Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, European Commission (EC), Science and Technology of Nuclear Fusion, Zohm, H, Ahn, J, Aho Mantila, L, Äkäslompolo, S, Angioni, C, Asunta, O, de Baar, M, Balden, M, Barrera Orte, L, Behler, K, Belapure, J, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boom, J, Böswirth, B, Bottereau, C, Bottino, A, van den Brand, H, Braun, F, Brezinsek, S, Brochard, F, Buhler, A, Burckhart, A, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carralero, D, Casali, L, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, Day, C, de Marné, P, Denner, P, D'Inca, R, Douai, D, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Ertl, K, Esposito, B, Fable, E, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Franzen, P, Frassinetti, L, Fröschle, M, Fuchert, G, Fünfgelder, H, Fuchs, J, Gál, K, Garavaglia, S, Garcia Muñoz, M, Geiger, B, Giannone, L, Giovannozzi, E, Gleason González, C, Görler, T, Goodman, T, Gorini, G, da Graca, S, Gräter, A, Granucci, G, Greuner, H, Grießhammer, J, Groth, M, Gude, A, Günter, S, Guimarais, L, Haas, G, Hakola, A, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hauff, T, Heinemann, B, Heinzel, S, Hellsten, T, Hennequin, P, Herrmann, A, Heyn, E, Hobirk, J, Hölzl, M, Höschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Jacob, W, Jacobsen, A, Jacquot, J, Janzer, M, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Käsemann, C, Kallenbach, A, Kálvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kim, D, Kimmig, S, Kirk, A, J, K, H, Kocan, M, Koch, F, Kocsis, G, Köhn, A, Köppen, M, Kötterl, J, Koslowski, R, Koubiti, M, Kraus, M, Krieger, K, Krivska, A, Kogut, D, Krämer Flecken, A, Kurki Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazányi, N, Lazaros, A, Lebschy, A, Leuterer, F, Liang, Y, Linsmeier, H, Lipschultz, B, Litnovski, A, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Mancini, A, Manhard, A, Mank, K, E, M, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Markina, E, Martens, C, Martin, P, Mayer, A, Mayer, M, Mazon, D, Mccarthy, P, Mcdermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Mertens, V, Meyer, H, Meyer, O, Milanesio, D, Miettunen, J, Mlynek, A, Monaco, F, Moro, A, Moseev, D, Müller, H, Müller, S, Münich, M, Nabais, F, Nemes Czopf, A, Neu, G, Neu, R, Nielsen, A, Nikolaeva, V, Nielsen, S, Nocente, M, Nold, B, M, N, J, Nowak, S, Oberkofler, M, Ochoukov, R, Odstrcil, T, Papp, G, Park, H, Pau, A, Pautasso, G, Penzel, F, Petersson, P, Piovesan, P, Piron, C, Plaum, B, Plöckl, B, Plyusnin, V, Podoba, Y, Pokol, G, Pompon, F, Poli, E, Polozhiy, K, Porte, L, Potzel, S, Preuss, R, Prisiazhniuk, D, Pütterich, T, Ramish, M, Rapson, C, Rasmussen, J, Rathgeber, S, Raupp, G, Réfy, D, Reich, M, Reimold, F, Reinke, M, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez Ramos, M, Rohde, V, Roth, J, Rott, M, Rubel, M, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneider, W, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shalpegin, A, Sias, G, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommer, F, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Sugiyama, K, J, S, Suttrop, W, Szepesi, T, Tál, B, Tala, T, Tardini, G, Tichmann, C, Told, D, Tophøj, L, Tudisco, O, von Toussaint, U, Trevisan, G, Treutterer, W, Tripský, M, Valisa, M, Valovic, M, Varela, P, Varoutis, S, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, Vorpahl, C, Wagner, D, Wang, X, Wauters, T, Weidl, I, Weiland, M, Weller, A, Wenninger, R, Wieland, B, Wiesinger, M, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Wünderlich, D, Würsching, E, Yang, Z, Yu, Q, Zammuto, I, Zarzoso, D, Zasche, D, van Zeeland, M, Zehetbauer, T, Zilker, M, Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society, and EUROfusion MST1 Team
- Subjects
Nuclear and High Energy Physics ,Tokamak ,Cyclotron ,Condensed Matter Physic ,Collisionality ,01 natural sciences ,Resonant magnetic perturbations ,Electron cyclotron resonance ,010305 fluids & plasmas ,law.invention ,Nuclear physics ,ASDEX Upgrade ,[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,law ,ITER ,0103 physical sciences ,010306 general physics ,Edge-localized mode ,tokamak physic ,DEMO ,nuclear fusion ,Physics ,Divertor ,Condensed Matter Physics ,Tokamak physics ,Nuclear fusion ,tokamak physics - Abstract
Recent experiments on the ASDEX Upgrade tokamak aim at improving the physics base for ITER and DEMO to aid the machine design and prepare efficient operation. Type I edge localized mode (ELM) mitigation using resonant magnetic perturbations (RMPs) has been shown at low pedestal collisionality ( ν ∗ ped < 0 . 4 ) . In contrast to the previous high ν ∗ regime, suppression only occurs in a narrow RMP spectral window, indicating a resonant process, and a concomitant confinement drop is observed due to a reduction of pedestal top density and electron temperature. Strong evidence is found for the ion heat flux to be the decisive element for the L–H power threshold. A physics based scaling of the density at which the minimum P LH occurs indicates that ITER could take advantage of it to initiate H-mode at lower density than that of the final Q = 10 operational point. Core density fluctuation measurements resolved in radius and wave number show that an increase of R/L T e introduced by off-axis electron cyclotron resonance heating (ECRH) mainly increases the large scale fluctuations. The radial variation of the fluctuation level is in agreement with simulations using the GENE code. Fast particles are shown to undergo classical slowing down in the absence of large scale magnetohydrodynamic (MHD) events and for low heating power, but show signs of anomalous radial redistribution at large heating power, consistent with a broadened off-axis neutral beam current drive current profile under these conditions. Neoclassical tearing mode (NTM) suppression experiments using electron cyclotron current drive (ECCD) with feedback controlled deposition have allowed to test several control strategies for ITER, including automated control of (3,2) and (2,1) NTMs during a single discharge. Disruption mitigation studies using massive gas injection (MGI) can show an increased fuelling efficiency with high field side injection, but a saturation of the fuelling efficiency is observed at high injected mass as needed for runaway electron suppression. Large locked modes can significantly decrease the fuelling efficiency and increase the asymmetry of radiated power during MGI mitigation. Concerning power exhaust, the partially detached ITER divertor scenario has been demonstrated at P sep /R = 10 MW m − 1 in ASDEX Upgrade, with a peak time averaged target load around 5MWm − 2 , well consistent with the component limits for ITER. Developing this towards DEMO, full detachment was achieved at P sep /R = 7MWm − 1 and stationary discharges with core radiation fraction of the order of DEMO requirements (70% instead of the 30% needed for ITER) were demonstrated. Finally, it remains difficult to establish the standard ITER Q = 10 scenario at low q 95 = 3 in the all-tungsten (all-W) ASDEX Upgrade due to the observed poor confinement at low β N . This is mainly due to a degraded pedestal performance and hence investigations at shifting the operational point to higher β N by lowering the current have been started. At higher q 95 , pedestal performance can be recovered by seeding N 2 as well as CD 4 , which is interpreted as improved pedestal stability due to the decrease of bootstrap current with increasing Z eff . Concerning advanced scenarios, the upgrade of ECRH power has allowed experiments with central ctr-ECCD to modify the q -profile in improved H-mode scenarios, showing an increase in confinement at still good MHD stability with flat elevated q -profiles at values between 1.5 and 2. European Commission (EUROfusion 633053)
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- 2015
13. Overview of ASDEX Upgrade results
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Aguiam, D, Aho-Mantila, L, Angioni, C, Arden, N, Parra, R, Asunta, O, Debaar, M, Balden, M, Behler, K, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boeswirth, B, Bottereau, C, Bottino, A, Van den Brand, H, Brezinsek, S, Brida, D, Brochard, F, Bruhn, C, Buchanan, J, Buhler, A, Burckhart, A, Cambon-Silva, D, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carr, M, Carralero, D, Casali, L, Castaldo, C, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, D'Arcangelo, O, Day, C, Delogu, R, de Marne, P, Denk, S, Denner, P, Dibon, M, D'Inca, R, Disiena, A, Douai, D, Drenik, A, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Erdos, B, Erofeev, I, Esposito, B, Fable, E, Faitsch, M, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Frassinetti, L, Freethy, S, Froeschle, M, Fuchert, G, Fuchs, J, Fuenfgelder, H, Galazka, K, Galdon-Quiroga, J, Gallo, A, Gao, Y, Garavaglia, S, Garcia-Munoz, M, Geiger, B, Cianfarani, C, Giannone, L, Giovannozzi, E, Gleason-Gonzalez, C, Gloeggler, S, Gobbin, M, Goerler, T, Goodman, T, Gorini, G, Gradic, D, Graeter, A, Granucci, G, Greuner, H, Griener, M, Groth, M, Gude, A, Guenter, S, Guimarais, L, Haas, G, Hakola, A, Ham, C, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hayward, T, Heinemann, B, Heinzel, S, Hellsten, T, Henderson, S, Hennequin, P, Herrmann, A, Heyn, E, Hitzler, F, Hobirk, J, Hoelzl, M, Hoeschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Ivanova-Stanik, I, Jacob, W, Jacobsen, A, Jacquot, J, Janky, F, Jardin, A, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Kaesemann, C, Kallenbach, A, Kalvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kasilov, S, Kernbichler, W, Kim, D, Kimmig, S, Kirk, A, Klingshirn, H, Koch, F, Kocsis, G, Koehn, A, Kraus, M, Krieger, K, Krivska, A, Kraemr-Flecken, A, Kurki-Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazanyi, N, Lazaros, A, Lebschy, A, Li, L, Li, M, Liang, Y, Lipschultz, B, Liu, Y, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Manas, P, Mancini, A, Manhard, A, Manso, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Martens, C, Martin, P, Marrelli, L, Martitsch, A, Mastrostefano, S, Mayer, A, Mayer, M, Mazon, D, Mccarthy, P, Mcdermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Merle, A, Mertens, V, Meshcheriakov, D, Meyer, H, Meyer, O, Miettunen, J, Milanesio, D, Mink, F, Mlynek, A, Monaco, F, Moon, C, Nazikian, R, Nemes-Czopf, A, Neu, G, Neu, R, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Noterdaeme, J, Nowak, S, Oberkofler, M, Oberparleiter, M, Ochoukov, R, Odstrcil, T, Olsen, J, Orain, F, Palermo, F, Papp, G, Paradela Perez, I, Pautasso, G, Enzel, F, Petersson, P, Pinzon, J, Piovesan, P, Piron, C, Plaum, B, Ploeckl, B, Plyusnin, V, Pokol, G, Poli, E, Porte, L, Potzel, S, Prisiazhniuk, D, Puetterich, T, Ramisch, M, Rapson, C, Rasmussen, J, Raupp, G, Refy, D, Reich, M, Reimold, F, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez-Ramos, M, Rohde, V, Ross, A, Rott, M, Rubel, M, Ryan, D, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis-Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz-Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shabbir, A, Shalpegin, A, Shao, L, Sharapov, S, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommariva, C, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Suarez, G, Sugiyama, K, Sun, H, Suttrop, W, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Terranova, D, Tierens, W, Told, D, Tudisco, O, Trevisan, G, Treutterer, W, Trier, E, Tripsky, M, Valisa, M, Valovic, M, Vanovac, B, Varela, P, Varoutis, S, Verdoolaege, G, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, von Toussaint, U, Wagner, D, Wang, N, Wang, X, Weidl, M, Weil, White, A, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Xiang, L, Yang, Q, Yang, Z, Yu, Q, Zagorski, R, Zammuto, I, Zarzoso, D, Zhang, W, van Zeeland, M, Zehetbauer, T, Zilker, M, Zoletnik, S, Zohm, H, Parra, RArredondo, deBaar, M, Coenen, JW, Coster, DP, DiSiena, A, Duval, BP, Fuchs, JC, Hakola, AH, Holm, JH, Jacobsen, AS, Klingshirn, H-J, Lang, PT, Luhmann, NC, Manso, M-E, McCarthy, PJ, McDermott, R, Nielsen, AH, Nielsen, SK, Noterdaeme, J-M, Schneider, PA, Sun, H-J, White, AE, Zohm, H., Aguiam, D, Aho-Mantila, L, Angioni, C, Arden, N, Parra, R, Asunta, O, Debaar, M, Balden, M, Behler, K, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boeswirth, B, Bottereau, C, Bottino, A, Van den Brand, H, Brezinsek, S, Brida, D, Brochard, F, Bruhn, C, Buchanan, J, Buhler, A, Burckhart, A, Cambon-Silva, D, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carr, M, Carralero, D, Casali, L, Castaldo, C, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, D'Arcangelo, O, Day, C, Delogu, R, de Marne, P, Denk, S, Denner, P, Dibon, M, D'Inca, R, Disiena, A, Douai, D, Drenik, A, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Erdos, B, Erofeev, I, Esposito, B, Fable, E, Faitsch, M, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Frassinetti, L, Freethy, S, Froeschle, M, Fuchert, G, Fuchs, J, Fuenfgelder, H, Galazka, K, Galdon-Quiroga, J, Gallo, A, Gao, Y, Garavaglia, S, Garcia-Munoz, M, Geiger, B, Cianfarani, C, Giannone, L, Giovannozzi, E, Gleason-Gonzalez, C, Gloeggler, S, Gobbin, M, Goerler, T, Goodman, T, Gorini, G, Gradic, D, Graeter, A, Granucci, G, Greuner, H, Griener, M, Groth, M, Gude, A, Guenter, S, Guimarais, L, Haas, G, Hakola, A, Ham, C, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hayward, T, Heinemann, B, Heinzel, S, Hellsten, T, Henderson, S, Hennequin, P, Herrmann, A, Heyn, E, Hitzler, F, Hobirk, J, Hoelzl, M, Hoeschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Ivanova-Stanik, I, Jacob, W, Jacobsen, A, Jacquot, J, Janky, F, Jardin, A, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Kaesemann, C, Kallenbach, A, Kalvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kasilov, S, Kernbichler, W, Kim, D, Kimmig, S, Kirk, A, Klingshirn, H, Koch, F, Kocsis, G, Koehn, A, Kraus, M, Krieger, K, Krivska, A, Kraemr-Flecken, A, Kurki-Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazanyi, N, Lazaros, A, Lebschy, A, Li, L, Li, M, Liang, Y, Lipschultz, B, Liu, Y, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Manas, P, Mancini, A, Manhard, A, Manso, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Martens, C, Martin, P, Marrelli, L, Martitsch, A, Mastrostefano, S, Mayer, A, Mayer, M, Mazon, D, Mccarthy, P, Mcdermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Merle, A, Mertens, V, Meshcheriakov, D, Meyer, H, Meyer, O, Miettunen, J, Milanesio, D, Mink, F, Mlynek, A, Monaco, F, Moon, C, Nazikian, R, Nemes-Czopf, A, Neu, G, Neu, R, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Noterdaeme, J, Nowak, S, Oberkofler, M, Oberparleiter, M, Ochoukov, R, Odstrcil, T, Olsen, J, Orain, F, Palermo, F, Papp, G, Paradela Perez, I, Pautasso, G, Enzel, F, Petersson, P, Pinzon, J, Piovesan, P, Piron, C, Plaum, B, Ploeckl, B, Plyusnin, V, Pokol, G, Poli, E, Porte, L, Potzel, S, Prisiazhniuk, D, Puetterich, T, Ramisch, M, Rapson, C, Rasmussen, J, Raupp, G, Refy, D, Reich, M, Reimold, F, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez-Ramos, M, Rohde, V, Ross, A, Rott, M, Rubel, M, Ryan, D, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis-Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz-Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shabbir, A, Shalpegin, A, Shao, L, Sharapov, S, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommariva, C, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Suarez, G, Sugiyama, K, Sun, H, Suttrop, W, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Terranova, D, Tierens, W, Told, D, Tudisco, O, Trevisan, G, Treutterer, W, Trier, E, Tripsky, M, Valisa, M, Valovic, M, Vanovac, B, Varela, P, Varoutis, S, Verdoolaege, G, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, von Toussaint, U, Wagner, D, Wang, N, Wang, X, Weidl, M, Weil, White, A, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Xiang, L, Yang, Q, Yang, Z, Yu, Q, Zagorski, R, Zammuto, I, Zarzoso, D, Zhang, W, van Zeeland, M, Zehetbauer, T, Zilker, M, Zoletnik, S, Zohm, H, Parra, RArredondo, deBaar, M, Coenen, JW, Coster, DP, DiSiena, A, Duval, BP, Fuchs, JC, Hakola, AH, Holm, JH, Jacobsen, AS, Klingshirn, H-J, Lang, PT, Luhmann, NC, Manso, M-E, McCarthy, PJ, McDermott, R, Nielsen, AH, Nielsen, SK, Noterdaeme, J-M, Schneider, PA, Sun, H-J, White, AE, and Zohm, H.
- Abstract
The ASDEX Upgrade (AUG) programme is directed towards physics input to critical elements of the ITER design and the preparation of ITER operation, as well as addressing physics issues for a future DEMO design. Since 2015, AUG is equipped with a new pair of 3-strap ICRF antennas, which were designed for a reduction of tungsten release during ICRF operation. As predicted, a factor two reduction on the ICRF-induced W plasma content could be achieved by the reduction of the sheath voltage at the antenna limiters via the compensation of the image currents of the central and side straps in the antenna frame. There are two main operational scenario lines in AUG. Experiments with low collisionality, which comprise current drive, ELM mitigation/suppression and fast ion physics, are mainly done with freshly boronized walls to reduce the tungsten influx at these high edge temperature conditions. Full ELM suppression and non-inductive operation up to a plasma current of MA could be obtained at low plasma density. Plasma exhaust is studied under conditions of high neutral divertor pressure and separatrix electron density, where a fresh boronization is not required. Substantial progress could be achieved for the understanding of the confinement degradation by strong D puffing and the improvement with nitrogen or carbon seeding. Inward/outward shifts of the electron density profile relative to the temperature profile effect the edge stability via the pressure profile changes and lead to improved/decreased pedestal performance. Seeding and D gas puffing are found to effect the core fueling via changes in a region of high density on the high field side (HFSHD). The integration of all above mentioned operational scenarios will be feasible and naturally obtained in a large device where the edge is more opaque for neutrals and higher plasma temperatures provide a lower collisionality. The combination of exhaust control with pellet fueling has been successfully demonstrated. High divert
- Published
- 2017
14. [Biological switches: the 'all-or-none' principle in T-cell activation]
- Author
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Kimmig S and Ria Baumgrass
- Subjects
T-Lymphocytes ,Models, Immunological ,Animals ,Cytokines ,Humans ,Interleukin-2 ,Cells, Cultured ,Immunity, Innate - Abstract
T helper lymphocytes (Th cells) play a central role in cellular defence against pathogens as well as in cellular self tolerance. The activation of Th cells is a crucial process determining the course of a protective immune response. Dysregulated activation processes can lead to pathologic immune reactions and may induce autoimmune diseases. Thus, for example, chronic activation of Th cells can trigger autoimmune diseases such as rheumatoid arthritis. One fundamental feature of antigen-specific T-cell activation is the synthesis of cytokines, e.g. Interleukin- (IL-)2. Here we present results of our working group indicating for the first time that, at the level of the individual cell, IL-2 is expressed in a binary fashion, i.e. according to an all-or-none principle. The identification and characterization of such intracellular switches may provide new options to manipulate the fate of T cells and develop novel therapeutic strategies.
- Published
- 2009
15. Fracture behaviour of SiC monofilament reinforced copper – an acoustic emission study
- Author
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Brendel, A, primary, Paffenholz, V, additional, and Kimmig, S, additional
- Published
- 2013
- Full Text
- View/download PDF
16. Establishment of juvenile and tolerant immune systems in patients with autoimmune diseases treated with immunoablation and autologous stem cell therapy
- Author
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Radbruch, A, Thiel, A, Kimmig, S, Alexander, T, Gromnica-Ihle, E, Hiepe, F, and Arnold, R
- Subjects
musculoskeletal diseases ,Tissue Inhibitor of Metalloproteinase-3 ,Disintegrins ,chondrocytes ,Metalloendopeptidases ,ADAMTS ,matrix metalloproteinases ,Review ,Extracellular Matrix ,ADAM Proteins ,osteoarthritis ,Cartilage ,ADAMTS1 Protein ,Poster Presentation ,Endopeptidases ,Meeting Abstract ,ADAMTS4 Protein ,Humans ,ADAMTS5 Protein ,Procollagen N-Endopeptidase ,Protein Processing, Post-Translational - Abstract
The loss of extracellular matrix macromolecules from the cartilage results in serious impairment of joint function. Metalloproteinases called 'aggrecanases' that cleave the Glu373–Ala374 bond of the aggrecan core protein play a key role in the early stages of cartilage destruction in rheumatoid arthritis and in osteoarthritis. Three members of the ADAMTS family of proteinases, ADAMTS-1, ADAMTS-4 and ADAMTS-5, have been identified as aggrecanases. Matrix metalloproteinases, which are also found in arthritic joints, cleave aggrecans, but at a distinct site from the aggrecanases (i.e. Asn341–Phe342). The present review discuss the enzymatic properties of the three known aggrecanases, the regulation of their activities, and their role in cartilage matrix breakdown during the development of arthritis in relation to the action of matrix metalloproteinases.
- Published
- 2003
17. [Untitled]
- Author
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Andreas Radbruch, R. Arnold, E Gromnica-Ihle, Andreas Thiel, Tobias Alexander, Falk Hiepe, and Kimmig S
- Subjects
0303 health sciences ,biology ,business.industry ,medicine.medical_treatment ,Naive B cell ,Autoantibody ,Stem-cell therapy ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Autologous stem-cell transplantation ,Immune system ,Rheumatology ,030220 oncology & carcinogenesis ,Cord blood ,Immunology ,biology.protein ,medicine ,Antibody ,Stem cell ,business ,030304 developmental biology - Abstract
Immunoablation (i.e. complete destruction of a patient's autoreactive immune system) in combination with autologous stem cell transplantation (ASCT) is used for treatment of severe autoimmune diseases. If successful, the patients will undergo long-term remission. We have analysed reconstitution of the immune system in such patients, to determine whether it recovers by expansion of surviving lymphocytes or develops from stem cells de novo. During a follow-up period of up to 60 months after ASCT, one polychondritis patient and two systemic lupus erythematosus patients in clinical remission were analysed for reappearance of naive, activated and memory B lymphocytes and T lymphocytes, for reactivity against pathogens and autoantigens, and for presence of autoantibodies. Titers of disease-specific autoantibodies decreased after ASCT with the half-life of secreted antibodies, and did not reappear. Naive T cells and naive B cells reappeared and reached normal levels within several months after ASCT. The repertoire of the naive T cells was not restricted. The numbers and frequencies of recent thymic emigrants (CD31+/CD45RA+/CD4+), marked by expression of T-cell receptor recombination excision circles, equalled those of cord blood and were considerably higher than in normal probands of the age of the patients. Thus, the thymus is reactivated and the reconstituted immune system rejuvenated and tolerized in those patients. The immunological memory has to be and is indeed generated de novo.
- Published
- 2003
18. Fracture behaviour of SiC monofilament reinforced copper – an acoustic emission study.
- Author
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Paffenholz, V, Kimmig, S, and Brendel, A
- Subjects
- *
METALLIC composites , *ACOUSTIC emission testing , *COPPER , *SILICON carbide fibers , *FIBROUS composites , *MEASUREMENT of tensile strength , *THERMAL conductivity ,ACOUSTIC properties of copper - Abstract
SiC monofilament-reinforced copper is a potential heat sink material for the divertor of future fusion reactors, where heat loads up to 15 MW/m2 must be removed. The composite combines high mechanical strength (300 MPa at 300℃) with sufficient thermal conductivity (at least 200 W/mK) at temperatures up to 550℃. The bonding between fibres and matrix is essential for the mechanical behaviour. We investigated two different fibre types (SCS0 and SCS6, Specialty Materials Inc.) with different interlayers in a galvanic copper matrix. Tensile tests in combination with acoustic emission analysis showed the dependence of fracture behaviour of the composite material on the fibre type. The average ultimate tensile strength of composite samples with 20% fibre reinforcement was in the range of 600 MPa, with a Young's modulus of 160 GPa. The tensile tested composite with SCS6 fibres generated roughly twenty times the number of acoustic emission events in comparison with the SCS0 fibres composite. Acoustic emission events in tensile test specimens with SCS6 fibres are correlated with the failure of the carbon-enriched surface layer of the fibre. In the case of SCS0 fibre-reinforced specimens, acoustic emission events were only caused by fibre failure. Fracture area analysis after tensile tests showed the failure of the SCS6 fibres at the interface between the two outer carbon layers and no interface failure for the composite with SCS0 fibres. [ABSTRACT FROM PUBLISHER]
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- 2014
- Full Text
- View/download PDF
19. Overview of ASDEX Upgrade results
- Author
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Kallenbach, A., Aguiam, D., Aho-Mantila, L., Angioni, C., Arden, N., Parra, R. Arredondo, Asunta, O., Baar, M., Balden, M., Behler, K., Bergmann, A., Bernardo, J., Bernert, M., Beurskens, M., Biancalani, A., Bilato, R., Birkenmeier, G., Bobkov, V., Bock, A., Bogomolov, A., Bolzonella, T., Boswirth, B., Bottereau, C., Bottino, A., Brand, H., Brezinsek, S., Brida, D., Brochard, F., Bruhn, C., Buchanan, J., Buhler, A., Burckhart, A., Cambon-Silva, D., Camenen, Y., Carvalho, P., Carrasco, G., Cazzaniga, C., Carr, M., Carralero, D., Casali, L., Castaldo, C., Cavedon, M., Challis, C., Chankin, A., Chapman, I., Clairet, F., Classen, I., Coda, S., Coelho, R., Coenen, J. W., Colas, L., Conway, G., Costea, S., Coster, D. P., Croci, G., Cseh, G., Czarnecka, A., D Arcangelo, O., Day, C., Delogu, R., Marne, P., Denk, S., Denner, P., Dibon, M., D Inca, R., Di Siena, A., Douai, D., Drenik, A., Drube, R., Dunne, M., Duval, B. P., Dux, R., Eich, T., Elgeti, S., Engelhardt, K., Erdos, B., Erofeev, I., Esposito, B., Fable, E., Faitsch, M., Fantz, U., Faugel, H., Felici, F., Fietz, S., Figueredo, A., Fischer, R., Ford, O., Frassinetti, L., Freethy, S., Froschle, M., Fuchert, G., Fuchs, J. C., Funfgelder, H., Galazka, K., Galdon-Quiroga, J., Gallo, A., Gao, Y., Garavaglia, S., Garcia-Munoz, M., Geiger, B., Cianfarani, C., Giannone, L., Giovannozzi, E., Gleason-Gonzalez, C., Gloggler, S., Gobbin, M., Gorler, T., Goodman, T., Gorini, G., Gradic, D., Grater, A., Granucci, G., Greuner, H., Griener, M., Groth, M., Gude, A., Gunter, S., Guimarais, L., Haas, G., Hakola, A. H., Ham, C., Happel, T., Harrison, J., Hatch, D., Hauer, V., Hayward, T., Heinemann, B., Heinzel, S., Hellsten, T., Henderson, S., Hennequin, P., Herrmann, A., Heyn, E., Hitzler, F., Hobirk, J., Holzl, M., Hoschen, T., Holm, J. H., Hopf, C., Hoppe, F., Horvath, L., Houben, A., Huber, A., Igochine, V., Ilkei, T., Ivanova-Stanik, I., Jacob, W., Jacobsen, A. S., Jacquot, J., Janky, F., Jardin, A., Jaulmes, F., Jenko, F., Jensen, T., Joffrin, E., Kasemann, C., Kalvin, S., Kantor, M., Kappatou, A., Kardaun, O., Karhunen, J., Kasilov, S., Kernbichler, W., Kim, D., Kimmig, S., Kirk, A., Klingshirn, H. -J, Koch, F., Kocsis, G., Kohn, A., Kraus, M., Krieger, K., Krivska, A., Kramer-Flecken, A., Kurki-Suonio, T., Kurzan, B., Lackner, K., Laggner, F., Lang, P. T., Lauber, P., Lazanyi, N., Lazaros, A., Lebschy, A., Li, L., Li, M., Liang, Y., Lipschultz, B., Liu, Y., Lohs, A., Luhmann, N. C., Lunt, T., Lyssoivan, A., Madsen, J., Maier, H., Maj, O., Mailloux, J., Maljaars, E., Manas, P., Mancini, A., Manhard, A., Manso, M. -E, Mantica, P., Mantsinen, M., Manz, P., Maraschek, M., Martens, C., Martin Oberkofler, Marrelli, L., Martitsch, A., Mastrostefano, S., Mayer, A., Mayer, M., Mazon, D., Mccarthy, P. J., Mcdermott, R., Meisl, G., Meister, H., Medvedeva, A., Merkel, P., Merkel, R., Merle, A., Mertens, V., Meshcheriakov, D., Meyer, H., Meyer, O., Miettunen, J., Milanesio, D., Mink, F., Mlynek, A., Monaco, F., Moon, C., Nazikian, R., Nemes-Czopf, A., Neu, G., Neu, R., Nielsen, A. H., Nielsen, S. K., Nikolaeva, V., Nocente, M., Noterdaeme, J. -M, Nowak, S., Oberkofler, M., Oberparleiter, M., Ochoukov, R., Odstrcil, T., Olsen, J., Orain, F., Palermo, F., Papp, G., Perez, I. Paradela, Pautasso, G., Enzel, F., Petersson, P., Pinzon, J., Piovesan, P., Piron, C., Plaum, B., Plockl, B., Plyusnin, V., Pokol, G., Poli, E., Porte, L., Potzel, S., Prisiazhniuk, D., Putterich, T., Ramisch, M., Rapson, C., Rasmussen, J., Raupp, G., Refy, D., Reich, M., Reimold, F., Ribeiro, T., Riedl, R., Rittich, D., Rocchi, G., Rodriguez-Ramos, M., Rohde, V., Ross, A., Rott, M., Rubel, M., Ryan, D., Ryter, F., Saarelma, S., Salewski, M., Salmi, A., Sanchis-Sanchez, L., Santos, G., Santos, J., Sauter, O., Scarabosio, A., Schall, G., Schmid, K., Schmitz, O., Schneider, P. A., Schneller, M., Schrittwieser, R., Schubert, M., Schwarz-Selinger, T., Schweinzer, J., Scott, B., Sehmer, T., Sertoli, M., Shabbir, A., Shalpegin, A., Shao, L., Sharapov, S., Siccinio, M., Sieglin, B., Sigalov, A., Silva, A., Silva, C., Simon, P., Simpson, J., Snicker, A., Sommariva, C., Sozzi, C., Spolaore, M., Stejner, M., Stober, J., Stobbe, F., Stroth, U., Strumberger, E., Suarez, G., Sugiyama, K., Sun, H. -J, Suttrop, W., Szepesi, T., Tal, B., Tala, T., Tardini, G., Tardocchi, M., Terranova, D., Tierens, W., Told, D., Tudisco, O., Trevisan, G., Treutterer, W., Trier, E., Tripsky, M., Valisa, M., Valovic, M., Vanovac, B., Varela, P., Varoutis, S., Verdoolaege, G., Vezinet, D., Vianello, N., Vicente, J., Vierle, T., Viezzer, E., Toussaint, U., Wagner, D., Wang, N., Wang, X., Weidl, M., Weiland, M., White, A. E., Willensdorfer, M., Wiringer, B., Wischmeier, M., Wolf, R., Wolfrum, E., Xiang, L., Yang, Q., Yang, Z., Yu, Q., Zagorski, R., Zammuto, I., Zarzoso, D., Zhang, W., Zeeland, M., Zehetbauer, T., Zilker, M., Zoletnik, S., Zohm, H., Team, Asdex Upgrade, Team, Eurofusion Mst, Institute of Forest Botany, Georg-August-University [Göttingen], Dutch Institute for Fundamental Energy Research [Eindhoven] (DIFFER), Institute of Applied Physics (IFA - CSIC), GRIDSEN, IPFN, Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Univ Tennessee, Dept Mat Sci & Engn, The University of Tennessee [Knoxville], Technical Research Centre of Finland, VTT Technical Research Centre of Finland (VTT), Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), CEA Cadarache, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Information Technology (INTEC), Universiteit Gent = Ghent University [Belgium] (UGENT), Institut für Geophysik [Clausthal-Zellerfeld], Technische Universität Clausthal (TU Clausthal), Association EURATOM-ÖAW, University of Innsbruck, Institut für Plasmaforschung [Stuttgart] (IPF), Universität Stuttgart [Stuttgart], Institute of Plasma Physics, Association Euratom/IPP.CR (IPP PRAGUE), Czech Academy of Sciences [Prague] (CAS), Department of Cancer Biology, University of Massachusetts Medical School [Worcester] (UMASS), University of Massachusetts System (UMASS)-University of Massachusetts System (UMASS), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Dipartimento di Fisica Università di Torino and INFN (DF_TORINO), Dipartimento di Fisica infi & Università di Torino, Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, Institut d'Electronique du Solide et des Systèmes (InESS), Centre National de la Recherche Scientifique (CNRS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences des Procédés et des Matériaux (LSPM), Université Paris 13 (UP13)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS), Institute for World Forestry, Johann Heinrich von Thünen Institute, Sygen International Plc, Genus Plc, Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut für Experimentelle und Angewandte Physik [Kiel] (IEAP), Christian-Albrechts-Universität zu Kiel (CAU), Department of Experimental Medical Science, AUTRES, Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Department of Obstetrics and Gynecology, Goethe-Universität Frankfurt am Main, Euratom/CCFE Fusion Association, Atomic Energy Research Institute [Budapest], Centre for Energy Research [Budapest] (MTAE), Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut de Chimie du CNRS (INC)-Institut National Polytechnique de Grenoble (INPG), ENEA C.R. Frascati, Via E. Fermi, 45, 00044 Frascati, Roma, Italy, affiliation inconnue, Department of Radiology, St. James's Hospital, Dept of Mechanical and Process Engineering, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Database group, Computer Science and engeenering Department [San Diego] (DB CSE UCSD), University of California [San Diego] (UC San Diego), University of California-University of California, F. Hoffmann-La RocheAG, Dutch Institute for Fundamental Energy Research [Eindhoven] ( DIFFER ), Institute of Applied Physics ( IFA - CSIC ), Instituto Superior Técnico, Universidade Técnica de Lisboa ( IST ), Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation ( IMEP-LAHC ), Centre National de la Recherche Scientifique ( CNRS ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Institut National Polytechnique de Grenoble ( INPG ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Université Grenoble Alpes ( UGA ), Institut de biologie et chimie des protéines [Lyon] ( IBCP ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), VTT Technical Research Centre of Finland ( VTT ), Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung ( AWI ), Laboratoire de Science et Génie des Matériaux et de Métallurgie ( LSG2M ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Department of Information Technology ( INTEC ), Ghent University [Belgium] ( UGENT ), Institut fur Geophysical, IPF, Institute of Plasma Physics, Association Euratom/IPP.CR ( IPP PRAGUE ), Czech Academy of Sciences [Prague] ( ASCR ), University of Massachusetts Medical School [Worcester] ( UMASS ), Institut de Recherche sur la Fusion par confinement Magnétique ( IRFM ), Dipartimento di Fisica Università di Torino and INFN ( DF_TORINO ), Forschungszentrum Jülich GmbH, Institut d'Electronique du Solide et des Systèmes ( InESS ), Centre National de la Recherche Scientifique ( CNRS ), Institut Jean Lamour ( IJL ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Lorraine ( UL ), Laboratoire des Sciences des Procédés et des Matériaux ( LSPM ), Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -Institut Galilée-Centre National de la Recherche Scientifique ( CNRS ), Institut de biologie moléculaire des plantes ( IBMP ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ), IEAP, Christian-Albrechts-Universität zu Kiel ( CAU ), Max-Planck-Institut für Plasmaphysik [Garching] ( IPP ), J. W. Goethe-University, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Science et Ingénierie des Matériaux et Procédés ( SIMaP ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Laboratoire de Physique Corpusculaire - Clermont-Ferrand ( LPC ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), university college cork, University College Cork ( UCC ), Eidgenössische Technische Hochschule [Zürich] ( ETH Zürich ), Database group, Computer Science and engeenering Department [San Diego] ( DB CSE UCSD ), University of California [San Diego] ( UC San Diego ), Aguiam, D, Aho-Mantila, L, Angioni, C, Arden, N, Parra, R, Asunta, O, Debaar, M, Balden, M, Behler, K, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boeswirth, B, Bottereau, C, Bottino, A, Van den Brand, H, Brezinsek, S, Brida, D, Brochard, F, Bruhn, C, Buchanan, J, Buhler, A, Burckhart, A, Cambon-Silva, D, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carr, M, Carralero, D, Casali, L, Castaldo, C, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, D'Arcangelo, O, Day, C, Delogu, R, de Marne, P, Denk, S, Denner, P, Dibon, M, D'Inca, R, Disiena, A, Douai, D, Drenik, A, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Erdos, B, Erofeev, I, Esposito, B, Fable, E, Faitsch, M, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Frassinetti, L, Freethy, S, Froeschle, M, Fuchert, G, Fuchs, J, Fuenfgelder, H, Galazka, K, Galdon-Quiroga, J, Gallo, A, Gao, Y, Garavaglia, S, Garcia-Munoz, M, Geiger, B, Cianfarani, C, Giannone, L, Giovannozzi, E, Gleason-Gonzalez, C, Gloeggler, S, Gobbin, M, Goerler, T, Goodman, T, Gorini, G, Gradic, D, Graeter, A, Granucci, G, Greuner, H, Griener, M, Groth, M, Gude, A, Guenter, S, Guimarais, L, Haas, G, Hakola, A, Ham, C, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hayward, T, Heinemann, B, Heinzel, S, Hellsten, T, Henderson, S, Hennequin, P, Herrmann, A, Heyn, E, Hitzler, F, Hobirk, J, Hoelzl, M, Hoeschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Ivanova-Stanik, I, Jacob, W, Jacobsen, A, Jacquot, J, Janky, F, Jardin, A, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Kaesemann, C, Kallenbach, A, Kalvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kasilov, S, Kernbichler, W, Kim, D, Kimmig, S, Kirk, A, Klingshirn, H, Koch, F, Kocsis, G, Koehn, A, Kraus, M, Krieger, K, Krivska, A, Kraemr-Flecken, A, Kurki-Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazanyi, N, Lazaros, A, Lebschy, A, Li, L, Li, M, Liang, Y, Lipschultz, B, Liu, Y, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Manas, P, Mancini, A, Manhard, A, Manso, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Martens, C, Martin, P, Marrelli, L, Martitsch, A, Mastrostefano, S, Mayer, A, Mayer, M, Mazon, D, Mccarthy, P, Mcdermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Merle, A, Mertens, V, Meshcheriakov, D, Meyer, H, Meyer, O, Miettunen, J, Milanesio, D, Mink, F, Mlynek, A, Monaco, F, Moon, C, Nazikian, R, Nemes-Czopf, A, Neu, G, Neu, R, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Noterdaeme, J, Nowak, S, Oberkofler, M, Oberparleiter, M, Ochoukov, R, Odstrcil, T, Olsen, J, Orain, F, Palermo, F, Papp, G, Paradela Perez, I, Pautasso, G, Enzel, F, Petersson, P, Pinzon, J, Piovesan, P, Piron, C, Plaum, B, Ploeckl, B, Plyusnin, V, Pokol, G, Poli, E, Porte, L, Potzel, S, Prisiazhniuk, D, Puetterich, T, Ramisch, M, Rapson, C, Rasmussen, J, Raupp, G, Refy, D, Reich, M, Reimold, F, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez-Ramos, M, Rohde, V, Ross, A, Rott, M, Rubel, M, Ryan, D, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis-Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz-Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shabbir, A, Shalpegin, A, Shao, L, Sharapov, S, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommariva, C, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Suarez, G, Sugiyama, K, Sun, H, Suttrop, W, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Terranova, D, Tierens, W, Told, D, Tudisco, O, Trevisan, G, Treutterer, W, Trier, E, Tripsky, M, Valisa, M, Valovic, M, Vanovac, B, Varela, P, Varoutis, S, Verdoolaege, G, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, von Toussaint, U, Wagner, D, Wang, N, Wang, X, Weidl, M, Weil, White, A, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Xiang, L, Yang, Q, Yang, Z, Yu, Q, Zagorski, R, Zammuto, I, Zarzoso, D, Zhang, W, van Zeeland, M, Zehetbauer, T, Zilker, M, Zoletnik, S, Zohm, H, Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratoire de Physique des Plasmas (LPP), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), York Plasma Institute (YPI), University of York [York, UK], EURATOM/CCFE Fusion Association, Culham Science Centre [Abingdon], Istituto di Fisica del Plasma, EURATOM-ENEA-CNR Association, Consiglio Nazionale delle Ricerche [Roma] (CNR), Leopold Franzens Universität Innsbruck - University of Innsbruck, Institute of Plasma Physics [Praha], Association EURATOM-TEKES, Helsinki University of Technology, Finland, Instituto de Plasmas e Fusão Nuclear [Lisboa] (IPFN), Institute of Atomic Physics, Université de Roumanie, FOM Institute for Atomic and Molecular Physics (AMOLF), FOM Institute DIFFER - Dutch Institute for Fundamental Energy Research, The Netherlands, Culham Centre for Fusion Energy (CCFE), University College Cork (UCC), Italian National agency for new technologies, Energy and sustainable economic development [Frascati] (ENEA), KFKI Research Institute for Particle and Nuclear Physics (KFKI-RMKI), National Technical University of Athens [Athens] (NTUA), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Department of Mechanical and Aerospace Engineering [Univ California San Diego] (MAE - UC San Diego), University of California (UC)-University of California (UC), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), General Atomics [San Diego], Ricerca Formazione Innovazione (Consorzio RFX), Warsaw University of Technology [Warsaw], Physique des interactions ioniques et moléculaires ( PIIM ), Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Max Planck Institute for Plasma Physics, Ecole Polytechnique Fédérale de Lausanne ( EPFL ), Laboratoire de Physique des Plasmas ( LPP ), Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Observatoire de Paris-École polytechnique ( X ) -Sorbonne Universités-PSL Research University ( PSL ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ), York Plasma Institute ( YPI ), Culham Science Centre, Consiglio Nazionale delle Ricerche [Roma] ( CNR ), Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. RNM138: Física Nuclear Aplicada, IST, VTT Technical Research Centre of Finland, Max Planck Inst Astrophys, Max Planck Society, Department of Applied Physics, TEC, JET EFDA, Culham Sci Ctr, Technische Universität München, Consorzio RFX, IRFM, Assoc EURATOM FZJ, Euratom, Julich Research Center, Forschungszentrum Julich, Inst Energy & Climate Res, University of Lorraine, ENEA, Istituto Fisica del Plasma 'Piero Caldirola' (IFP-CNR), Swiss Federal Institute of Technology Lausanne, Innsbruck Medical University, Hungarian Academy of Sciences, Institute of Plasma Physics & Laser Microfusion (IFPiLM), Karlsruhe Institute of Technology, Eindhoven University of Technology, Swedish Research Council (VR), General Atomics & Affiliated Companies, University of Sevilla, University of Texas at Austin, Max Planck Comp & Data Facil, Ecole Polytechnique, Hochschule der Medien, Technical University of Denmark, Budapest University of Technology and Economics, University of California at Santa Barbara, School services, SCI, LPP-ERM/KMS EURATOM Association, Vienna University of Technology, Assoc EURATOM Hellen Republ, NCSR Demokritos, IPP, York University, CCFE Fusion Assoc, BSC, Univ Coll Cork UCC, Princeton University, Ghent University, Chinese Acad Sci, Chinese Academy of Sciences, Natl Astron Observ, Department of Radio Science and Engineering, Massachusetts Institute of Technology, Chinese Academy of Sciences, Univ Aix Marseille 1, Centre National de la Recherche Scientifique (CNRS), University of Aix-Marseille, Universite de Provence - Aix-Marseille I, UMR 6098, CNRS, Aalto-yliopisto, Aalto University, Massachusetts Institute of Technology. Plasma Science and Fusion Center, White, Anne E., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Arslanbekov, R, Atanasiu, C, Becker, G, Becker, W, Behringer, K, Bolshukhin, D, Borrass, K, Brambilla, M, Braun, F, Carlson, A, Egorov, S, Fahrbach, H, Finken, K, Foley, M, Franzen, P, Gafert, J, Fournier, K, Gantenbein, G, Gehre, O, Geier, A, Gernhardt, J, Gruber, O, Gunter, S, Hartmann, D, Heger, B, Hofmeister, F, Hohenocker, H, Horton, L, Jacchia, A, Jakobi, M, Kaufmann, M, Keller, A, Kendl, A, Kim, J, Kirov, K, Kochergov, R, Kollotzek, H, Kraus, W, Lasnier, C, Laux, M, Leonard, A, Leuterer, F, Lorenz, A, Lorenzini, R, Maggi, C, Mank, K, Martines, E, Mast, K, Meisel, D, Meo, F, Merkl, D, Muck, A, Muller, H, Munich, M, Murmann, H, Na, Y, Neuhauser, J, Nguyen, F, Nishijima, D, Nishimura, Y, Nunes, I, Peeters, A, Pereverzev, G, Pinches, S, Proschek, M, Pugno, R, Quigley, E, Roth, J, Sandmann, W, Savtchkov, A, Schade, S, Schilling, H, Schneider, W, Schramm, G, Schwarz, E, Schweizer, S, Seidel, U, Serra, F, Sesnic, S, Sihler, C, Sips, A, Speth, E, Stabler, A, Steuer, K, Streibl, B, Tabasso, A, Tanga, A, Tichmann, C, Troppmann, M, Urano, H, Vollmer, O, Wenzel, U, Wesner, F, Westerhof, E, Wursching, E, Yoon, S, Zasche, D, Zehrfeld, H, Barcelona Supercomputing Center, ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society, EUROfusion MST1 Team, Adamek, J, Aho Mantila, L, Akaslompolo, S, Amdor, C, Bardin, S, Orte, L, Belonohy, E, Boom, J, Brochard, T, Bruedgam, M, Casson, F, Curran, D, da Silva, F, Eixenberger, H, Endstrasser, N, Gal, K, Munoz, M, da Graca, S, Hangan, D, Haertl, T, Hauff, T, Hoehnle, H, Ionita, C, Janzer, A, Kasparek, W, Kocan, M, Konz, C, Koslowski, R, Kubic, M, Kurki Suonio, T, Leipold, F, Lindig, S, Lisgo, S, Makkonen, T, Mehlmann, F, Menchero, L, Merz, F, Mueller, S, Mueller, H, Muenich, M, Neuwirth, D, Nold, B, Podoba, Y, Pompon, F, Polozhiy, K, Pueschel, M, Rathgeber, S, Rooij, G, Sauter, P, Sempf, M, Sommer, F, Staebler, A, Teschke, M, Tsalas, M, Van Zeeland, M, Veres, G, Viola, B, Vorpahl, C, Wachowski, M, Wauters, T, Weller, A, Wenninger, R, Wieland, B, Wuersching, E, Zhang, Y, Science and Technology of Nuclear Fusion, Max Planck IPP-EURATOM Assoziation, Universidade de Lisboa, Dutch Institute for Fundamental Energy Research, Technical University of Munich, IRFM-CEA, Forschungszentrum Jülich, Université de Lorraine, and École Polytechnique Fedérale de Lausanne
- Subjects
Nuclear and High Energy Physics ,Tokamak ,Materials science ,Energies [Àrees temàtiques de la UPC] ,114 Physical sciences ,7. Clean energy ,01 natural sciences ,Electron cyclotron resonance ,H-MODE DISCHARGES ,010305 fluids & plasmas ,law.invention ,ASDEX Upgrade, overview ,ASDEX Upgrade ,law ,[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,Physics::Plasma Physics ,ITER ,0103 physical sciences ,Fusió nuclear ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,010306 general physics ,tokamak ,DEMO ,tokamak physic ,Fusion reactions ,nuclear fusion ,Divertor ,Magnetic confinement fusion ,[ SPI.GPROC ] Engineering Sciences [physics]/Chemical and Process Engineering ,[ PHYS.PHYS.PHYS-PLASM-PH ] Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph] ,Fusion power ,Condensed Matter Physics ,___ ,Plasma parameter ,Plasma diagnostics ,Atomic physics ,tokamak physics - Abstract
The ASDEX Upgrade (AUG) programme is directed towards physics input to critical elements of the ITER design and the preparation of ITER operation, as well as addressing physics issues for a future DEMO design. Since 2015, AUG is equipped with a new pair of 3-strap ICRF antennas, which were designed for a reduction of tungsten release during ICRF operation. As predicted, a factor two reduction on the ICRF-induced W plasma content could be achieved by the reduction of the sheath voltage at the antenna limiters via the compensation of the image currents of the central and side straps in the antenna frame. There are two main operational scenario lines in AUG. Experiments with low collisionality, which comprise current drive, ELM mitigation/suppression and fast ion physics, are mainly done with freshly boronized walls to reduce the tungsten influx at these high edge temperature conditions. Full ELM suppression and non-inductive operation up to a plasma current of I p = 0.8 MA could be obtained at low plasma density. Plasma exhaust is studied under conditions of high neutral divertor pressure and separatrix electron density, where a fresh boronization is not required. Substantial progress could be achieved for the understanding of the confinement degradation by strong D puffing and the improvement with nitrogen or carbon seeding. Inward/outward shifts of the electron density profile relative to the temperature profile effect the edge stability via the pressure profile changes and lead to improved/decreased pedestal performance. Seeding and D gas puffing are found to effect the core fueling via changes in a region of high density on the high field side (HFSHD). The integration of all above mentioned operational scenarios will be feasible and naturally obtained in a large device where the edge is more opaque for neutrals and higher plasma temperatures provide a lower collisionality. The combination of exhaust control with pellet fueling has been successfully demonstrated. High divertor enrichment values of nitrogen E N ⩾ 10 have been obtained during pellet injection, which is a prerequisite for the simultaneous achievement of good core plasma purity and high divertor radiation levels. Impurity accumulation observed in the all-metal AUG device caused by the strong neoclassical inward transport of tungsten in the pedestal is expected to be relieved by the higher neoclassical temperature screening in larger devices.
20. Evolution of nitrogen concentration and ammonia production in N-2-seeded H-mode discharges at ASDEX Upgrade
- Author
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Drenik, A., Laguardia, L., McDermott, R., Meisl, G., Neu, R., Oberkofler, M., Pawelec, E., Pitts, R. A., Puetterich, T., Reichbauer, T., Rohde, V., Seibt, M., De Temmerman, G., Zaplotnik, R., Aguiam, D., Aho-Mantila, L., Angioni, C., Arden, N., Parra, R. Arredondo, Asunta, O., de Baar, M., Balden, M., Behler, K., Bergmann, A., Bernardo, J., Bernert, M., Beurskens, M., Biancalani, A., Bilato, R., Birkenmeier, G., Bobkov, V., Bock, A., Bogomolov, A., Bolzonella, T., Boswirth, B., Bottereau, C., Bottino, A., van den Brand, H., Brezinsek, S., Brida, D., Brochard, F., Bruhn, C., Buchanan, J., Buhler, A., Burckhart, A., Cambon-Silva, D., Camenen, Y., Carvalho, P., Carrasco, G., Cazzaniga, C., Carr, M., Carralero, D., Casali, L., Castaldo, C., Cavedon, M., Challis, C., Chankin, A., Chapman, I., Clairet, F., Classen, I., Coda, S., Coelho, R., Coenen, J. W., Colas, L., Conway, G., Costea, S., Coster, D. P., Croci, G., Cseh, G., Czarnecka, A., D'Arcangelo, O., Day, C., Delogu, R., de Marne, P., Denk, S., Denner, P., Dibon, M., D'Inca, R., Di Siena, A., Douai, D., Drube, R., Dunne, M., Duval, B. P., Dux, R., Eich, T., Elgeti, S., Engelhardt, K., Erdos, B., Erofeev, I., Esposito, B., Fable, E., Faitsch, M., Fantz, U., Faugel, H., Felici, F., Fietz, S., Figueredo, A., Fischer, R., Ford, O., Frassinetti, L., Freethy, S., Froeschle, M., Fuchert, G., Fuchs, J. C., Fuenfgelder, H., Galazka, K., Galdon-Quiroga, J., Gallo, A., Gao, Y., Garavaglia, S., Garcia-Munoz, M., Geiger, B., Cianfarani, C., Giannone, L., Giovannozzi, E., Gleason-Gonzalez, C., Gloeggler, S., Gobbin, M., Goerler, T., Goodman, T., Gorini, G., Gradic, D., Graeter, A., Granucci, G., Greuner, H., Griener, M., Groth, M., Gude, A., Guenter, S., Guimarais, L., Haas, G., Hakola, A. H., Ham, C., Happel, T., Harrison, J., Hatch, D., Hauer, V., Hayward, T., Heinemann, B., Heinzel, S., Hellsten, T., Henderson, S., Hennequin, P., Herrmann, A., Heyn, E., Hitzler, F., Hobirk, J., Hoelzl, M., Hoeschen, T., Holm, J. H., Hopf, C., Hoppe, F., Horvath, L., Houben, A., Huber, A., Igochine, V., Ilkei, T., Ivanova-Stanik, I., Jacob, W., Jacobsen, A. S., Jacquot, J., Janky, F., Jardin, A., Jaulmes, F., Jenko, F., Jensen, T., Joffrin, E., Kaesemann, C., Kallenbach, A., Kalvin, S., Kantor, M., Kappatou, A., Kardaun, O., Karhunen, J., Kasilov, S., Kernbichler, W., Kim, D., Kimmig, S., Kirk, A., Klingshirn, H. -J., Koch, F., Kocsis, G., Koehn, A., Kraus, M., Krieger, K., Krivska, A., Kraemer-Flecken, A., Kurki-Suonio, T., Kurzan, B., Lackner, K., Laggner, F., Lang, P. T., Lauber, P., Lazanyi, N., Lazaros, A., Lebschy, A., Li, L., Li, M., Liang, Y., Lipschultz, B., Liu, Y., Lohs, A., Luhmann, N. C., Lunt, T., Lyssoivan, A., Madsen, J., Maier, H., Maj, O., Mailloux, J., Maljaars, E., Manas, P., Mancini, A., Manhard, A., Manso, M. -E., Mantica, P., Mantsinen, M., Manz, P., Maraschek, M., Martens, C., Martin, P., Marrelli, L., Martitsch, A., Mastrostefano, S., Mayer, A., Mayer, M., Mazon, D., McCarthy, P. J., Meister, H., Medvedeva, A., Merkel, P., Merkel, R., Merle, A., Mertens, V., Meshcheriakov, D., Meyer, H., Meyer, O., Miettunen, J., Milanesio, D., Mink, F., Mlynek, A., Monaco, F., Moon, C., Nazikian, R., Nemes-Czopf, A., Neu, G., Nielsen, A. H., Nielsen, S. K., Nikolaeva, V., Nocente, M., Noterdaeme, J. -M., Nowak, S., Oberparleiter, M., Ochoukov, R., Odstrcil, T., Olsen, J., Orain, F., Palermo, F., Papp, G., Perez, I. Paradela, Pautasso, G., Enzel, F., Petersson, P., Pinzon, J., Piovesan, P., Piron, C., Plaum, B., Ploeckl, B., Plyusnin, V., Pokol, G., Poli, E., Porte, L., Potzel, S., Prisiazhniuk, D., Ramisch, M., Rapson, C., Rasmussen, J., Raupp, G., Refy, D., Reich, M., Reimold, F., Ribeiro, T., Riedl, R., Rittich, D., Rocchi, G., Rodriguez-Ramos, M., Ross, A., Rott, M., Rubel, M., Ryan, D., Ryter, F., Saarelma, S., Salewski, M., Salmi, A., Sanchis-Sanchez, L., Santos, G., Santos, J., Sauter, O., Scarabosio, A., Schall, G., Schmid, K., Schmitz, O., Schneider, P. A., Schneller, M., Schrittwieser, R., Schubert, M., Schwarz-Selinger, T., Schweinzer, J., Scott, B., Sehmer, T., Sertoli, M., Shabbir, A., Shalpegin, A., Shao, L., Sharapov, S., Siccinio, M., Sieglin, B., Sigalov, A., Silva, A., Silva, C., Simon, P., Simpson, J., Snicker, A., Sommariva, C., Sozzi, C., Spolaore, M., Stejner, M., Stober, J., Stobbe, F., Stroth, U., Strumberger, E., Suarez, G., Sugiyama, K., Sun, H. -J., Suttrop, W., Szepesi, T., Tal, B., Tala, T., Tardini, G., Tardocchi, M., Terranova, D., Tierens, W., Told, D., Tudisco, O., Trevisan, G., Treutterer, W., Trier, E., Tripsky, M., Valisa, M., Valovic, M., Vanovac, B., Varela, P., Varoutis, S., Verdoolaege, G., Vezinet, D., Vianello, N., Vicente, J., Vierle, T., Viezzer, E., von Toussaint, U., Wagner, D., Wang, N., Wang, X., Weidl, M., Weiland, M., White, A. E., Willensdorfer, M., Wiringer, B., Wischmeier, M., Wolf, R., Wolfrum, E., Xiang, L., Yang, Q., Yang, Z., Yu, Q., Zagorski, R., Zammuto, I., Zarzoso, D., Zhang, W., van Zeeland, M., Zehetbauer, T., Zilker, M., Zoletnik, S., and Zohm, H.
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nitrogen seeding ,residual gas analysis ,asdex upgrade ,n-2-h-2 flowing discharges ,plasma-surface interaction ,consistent kinetic-model ,ammonia ,mass spectrometry - Abstract
Ammonia formation was studied in a series of dedicated nitrogen seeded H-mode discharges at ASDEX Upgrade. The evolution of ammonia formation was investigated with a reference phase before the seeding, and a long, stable flat-top nitrogen-seeded phase. It was monitored with divertor spectroscopy and analysis of the exhaust gas. The amount of the detected ammonia increased continuously over the course of five discharges with the same nitrogen seeding rate. The same trend was observed in the nitrogen density in the core plasma, as measured by charge exchange recombination spectroscopy and other signals, linked to the effects of nitrogen seeding. The results show that the rate of ammonia formation exhibited the same trend as the nitrogen density in the plasma. This density, in turn, was strongly influenced by the nitrogen wall inventory. The spatial distribution of the detected ammonia suggests that a significant contribution to the net ammonia formation is made in plasma-shaded areas, through surface reactions of neutral species.
21. Validation of the ICRF antenna coupling code RAPLICASOL against TOPICA and experiments
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Tierens, W., Milanesio, D., Urbanczyk, G., Helou, W., Bobkov, V, Noterdaeme, J-M, Colas, L., Maggiora, R., Aguiam, D., Aho-Mantila, L., Angioni, C., Arden, N., Parra, R. Arredondo, Asunta, O., de Baar, M., Balden, M., Behler, K., Bergmann, A., Bernardo, J., Bernert, M., Beurskens, M., Biancalani, A., Bilato, R., Birkenmeier, G., Bock, A., Bogomolov, A., Bolzonella, T., Boeswirth, B., Bottereau, C., Bottino, A., van den Brand, H., Brezinsek, S., Brida, D., Brochard, F., Bruhn, C., Buchanan, J., Buhler, A., Burckhart, A., Cambon-Silva, D., Camenen, Y., Carvalho, P., Carrasco, G., Cazzaniga, C., Carr, M., Carralero, D., Casali, L., Castaldo, C., Cavedon, M., Challis, C., Chankin, A., Chapman, I, Clairet, F., Classen, I, Coda, S., Coelho, R., Coenen, J. W., Conway, G., Costea, S., Coster, D. P., Croci, G., Cseh, G., Czarnecka, A., D'Arcangelo, O., Day, C., Delogu, R., de Marne, P., Denk, S., Denner, P., Dibon, M., D'Inca, R., Di Siena, A., Douai, D., Drenik, A., Drube, R., Dunne, M., Duval, B. P., Dux, R., Eich, T., Elgeti, S., Engelhardt, K., Erdos, B., Erofeev, I, Esposito, B., Fable, E., Faitsch, M., Fantz, U., Faugel, H., Felici, F., Fietz, S., Figueredo, A., Fischer, R., Ford, O., Frassinetti, L., Freethy, S., Froeschle, M., Fuchert, G., Fuchs, J. C., Fuenfgelder, H., Galazka, K., Galdon-Quiroga, J., Gallo, A., Gao, Y., Garavaglia, S., Garcia-Munoz, M., Geiger, B., Cianfarani, C., Giannone, L., Giovannozzi, E., Gleason-Gonzalez, C., Gloeggler, S., Gobbin, M., Goerler, T., Goodman, T., Gorini, G., Gradic, D., Graeter, A., Granucci, G., Greuner, H., Griener, M., Groth, M., Gude, A., Guenter, S., Guimarais, L., Haas, G., Hakola, A. H., Ham, C., Happel, T., Harrison, J., Hatch, D., Hauer, V, Hayward, T., Heinemann, B., Heinzel, S., Hellsten, T., Henderson, S., Hennequin, P., Herrmann, A., Heyn, E., Hitzler, F., Hobirk, J., Hoelzl, M., Hoeschen, T., Holm, J. H., Hopf, C., Hoppe, F., Horvath, L., Houben, A., Huber, A., Igochine, V, Ilkei, T., Ivanova-Stanik, I., Jacob, W., Jacobsen, A. S., Jacquot, J., Janky, F., Jardin, A., Jaulmes, F., Jenko, F., Jensen, T., Joffrin, E., Kaesemann, C., Kallenbach, A., Kalvin, S., Kantor, M., Kappatou, A., Kardaun, O., Karhunen, J., Kasilov, S., Kernbichler, W., Kim, D., Kimmig, S., Kirk, A., Klingshirn, H-J, Koch, F., Kocsis, G., Koehn, A., Kraus, M., Krieger, K., Krivska, A., Kraemer-Flecken, A., Kurki-Suonio, T., Kurzan, B., Lackner, K., Laggner, F., Lang, P. T., Lauber, P., Lazanyi, N., Lazaros, A., Lebschy, A., Li, L., Li, M., Liang, Y., Lipschultz, B., Liu, Y., Lohs, A., Luhmann, N. C., Lunt, T., Lyssoivan, A., Madsen, J., Maier, H., Maj, O., Mailloux, J., Maljaars, E., Manas, P., Mancini, A., Manhard, A., Manso, M-E, Mantica, P., Mantsinen, M., Manz, P., Maraschek, M., Martens, C., Martin, P., Marrelli, L., Martitsch, A., Mastrostefano, S., Mayer, A., Mayer, M., Mazon, D., McCarthy, P. J., McDermott, R., Meisl, G., Meister, H., Medvedeva, A., Merkel, P., Merkel, R., Merle, A., Mertens, V, Meshcheriakov, D., Meyer, H., Meyer, O., Miettunen, J., Mink, F., Mlynek, A., Monaco, F., Moon, C., Nazikian, R., Nemes-Czopf, A., Neu, G., Neu, R., Nielsen, A. H., Nielsen, S. K., Nikolaeva, V, Nocente, M., Nowak, S., Oberkofler, M., Oberparleiter, M., Ochoukov, R., Odstrcil, T., Olsen, J., Orain, F., Palermo, F., Papp, G., Perez, I. Paradela, Pautasso, G., Enzel, F., Petersson, P., Pinzon, J., Piovesan, P., Piron, C., Plaum, B., Ploeckl, B., Plyusnin, V, Pokol, G., Poli, E., Porte, L., Potzel, S., Prisiazhniuk, D., Puetterich, T., Ramisch, M., Rapson, C., Rasmussen, J., Raupp, G., Refy, D., Reich, M., Reimold, F., Ribeiro, T., Riedl, R., Rittich, D., Rocchi, G., Rodriguez-Ramos, M., Rohde, V, Ross, A., Rott, M., Rubel, M., Ryan, D., Ryter, F., Saarelma, S., Salewski, M., Salmi, A., Sanchis-Sanchez, L., Santos, G., Santos, J., Sauter, O., Scarabosio, A., Schall, G., Schmid, K., Schmitz, O., Schneider, P. A., Schneller, M., Schrittwieser, R., Schubert, M., Schwarz-Selinger, T., Schweinzer, J., Scott, B., Sehmer, T., Sertoli, M., Shabbir, A., Shalpegin, A., Shao, L., Sharapov, S., Siccinio, M., Sieglin, B., Sigalov, A., Silva, A., Silva, C., Simon, P., Simpson, J., Snicker, A., Sommariva, C., Sozzi, C., Spolaore, M., Stejner, M., Stober, J., Stobbe, F., Stroth, U., Strumberger, E., Suarez, G., Sugiyama, K., Sun, H-J, Suttrop, W., Szepesi, T., Tal, B., Tala, T., Tardini, G., Tardocchi, M., Terranova, D., Told, D., Tudisco, O., Trevisan, G., Treutterer, W., Trier, E., Tripsky, M., Valisa, M., Valovic, M., Vanovac, B., Varela, P., Varoutis, S., Verdoolaege, G., Vezinet, D., Vianello, N., Vicente, J., Vierle, T., Viezzer, E., von Toussaint, U., Wagner, D., Wang, N., Wang, X., Weidl, M., Weiland, M., White, A. E., Willensdorfer, M., Wiringer, B., Wischmeier, M., Wolf, R., Wolfrum, E., Xiang, L., Yang, Q., Yang, Z., Yu, Q., Zagorski, R., Zammuto, I, Zarzoso, D., Zhang, W., van Zeeland, M., Zehetbauer, T., Zilker, M., Zoletnik, S., Zohm, H., Hakola, A., Adamek, J., Agostini, M., Ahn, J., Akers, R., Albanese, R., Aledda, R., Alessi, E., Allan, S., Alves, D., Ambrosino, R., Amicucci, L., Anand, H., Anastassiou, G., Andrebe, Y., Apruzzese, G., Ariola, M., Arnichand, H., Arter, W., Baciero, A., Barnes, M., Barrera, L., Behn, R., Bencze, A., Bettini, P., Bilkova, P., Bin, W., Bizarro, J. P. S., Blanchard, P., Blanken, T., Bluteau, M., Bogar, O., Bohm, P., Boncagni, L., Botrugno, A., Bouquey, F., Bourdelle, C., Bremond, S., Bufferand, H., Buratti, P., Cahyna, P., Calabro, G., Caniello, R., Cannas, B., Canton, A., Cardinali, A., Carnevale, D., Castejon, F., Castro, R., Causa, F., Cavazzana, R., Cecconello, M., Ceccuzzi, S., Cesario, R., Challis, C. D., Chapman, I. T., Chapman, S., Chernyshova, M., Choi, D., Ciraolo, G., Citrin, J., Corre, Y., Crisanti, F., Cruz, N., De Angeli, M., De Masi, G., De Temmerman, G., De Tommasi, G., Decker, J., Delogu, R. S., Dendy, R., Di Troia, C., Dimitrova, M., Doric, V, Dudson, B., Dunai, D., Easy, L., Elmore, S., Fanni, A., Fedorczak, N., Ferreira, J., Fevrier, O., Ficker, O., Figini, L., Figueiredo, A., Fil, A., Fishpool, G., Fitzgerald, M., Fontana, M., Fridstrom, R., Frigione, D., Fuchs, C., Palumbo, M. Furno, Futatani, S., Gabellieri, L., Galeani, S., Gallart, D., Galperti, C., Garcia, J., Garcia-Carrasco, A., Garcia-Lopez, J., Gardarein, J-L, Garzotti, L., Gaspar, J., Gauthier, E., Geelen, P., Ghendrih, P., Ghezzi, F., Giacomelli, L., Giroud, C., Gonzalez, C. Gleason, Goodman, T. P., Gospodarczyk, M., Gruber, M., Guirlet, R., Gunn, J., Hacek, P., Hacquin, S., Hall, S., Harting, D., Havlickova, E., Heyn, M., Hnat, B., Holzl, M., Hogeweij, D., Honore, C., Horacek, J., Hornung, G., Huang, Z., Igitkhanov, J., Imrisek, M., Innocente, P., Ionita-Schrittwieser, C., Isliker, H., Jacquet, P., Jakubowski, M., Busk, O. Jeppe Miki, Jessen, M., Jones, O., Jonsson, T., Kallinikos, N., Karpushov, A., Kasprowicz, G., Kendl, A., Kjer, S., Klimek, I, Kogut, D., Komm, M., Korsholm, S. B., Koslowski, H. R., Koubiti, M., Kovacic, J., Kovarik, K., Krawczyk, N., Krbec, J., Kube, R., Kudlacek, O., Labit, B., Laggner, F. M., Laguardia, L., Lahtinen, A., Lalousis, P., Lang, P., Le, H. B., Leddy, J., Lefevre, L., Lehnen, M., Leipold, F., Lessig, A., Leyland, M., Liu, Y. Q., Loarer, T., Loarte, A., Loewenhoff, T., Lomanowski, B., Loschiavo, V. P., Lupelli, I, Lux, H., Maget, P., Maggi, C., Magnussen, M. L., Maljaars, B., Malygin, A., Marchand, B., Marconato, N., Marini, C., Marinucci, M., Markovic, T., Marocco, D., Martin, Y., Martin Solis, J. R., Mattei, M., Matthews, G., Mavridis, M., Mayoral, M-L, McCarthy, P., McAdams, R., McArdle, G., McClements, K., McMillan, B., Militello, F., Miron, I. G., Mitosinkova, K., Mlynar, J., Molina, D., Molina, P., Monakhov, I, Morales, J., Moreau, D., Morel, P., Moret, J-M, Moro, A., Moulton, D., Mueller, H. W., Nabais, F., Nardon, E., Naulin, V, Nespoli, F., Nimb, S., Nouailletas, R., Omotani, J., O'Mullane, M. G., Osterman, N., Paccagnella, R., Pamela, S., Pangione, L., Panjan, M., Paprok, R., Parail, V, Parra, F. I., Pau, A., Pehkonen, S-P, Pereira, A., Cippo, E. Perelli, Ridolfini, V. Pericoli, Peterka, M., Petrzilka, V, Pironti, A., Pisano, F., Pisokas, T., Pitts, R., Ploumistakis, I, Poljak, D., Poloskei, P., Popovic, Z., Por, G., Predebon, I, Preynas, M., Primc, G., Pucella, G., Puiatti, M. E., Rack, M., Ramogida, G., Rasmussen, J. Juul, Ratta, G. A., Ratynskaia, S., Ravera, G., Reimerdes, H., Reinke, M., Reiser, D., Resnik, M., Reux, C., Ripamonti, D., Riva, G., Rosato, J., Sabot, R., Saint-Laurent, F., Samaddar, D., Scannell, R., Scheffer, M., Schneider, M., Schneider, B., Schneider, P., Seidl, J., Sesnic, S., Shanahan, B., Sheikh, U., Sias, G., Fuglister, M. Silva, Spagnolo, S., Spizzo, G., Stange, T., Pedersen, M. Stejner, Stepanov, I, Strand, P., Susnjara, A., Tamain, P., Teplukhina, A., Testa, D., Theiler, C., Thornton, A., Tolias, P., Tophoj, L., Trevisan, G. L., Tsironis, C., Tsui, C., Uccello, A., Urban, J., Vallejos, P., Vartanian, S., Vega, J., Verhaegh, K., Vermare, L., Vignitchouk, L., Vijvers, W. A. J., Villone, F., Viola, B., Vlahos, L., Voitsekhovitch, I, Vondracek, P., Vu, N. M. T., Walkden, N., Wauters, T., Weinzettl, V, Westerhof, E., Wiesenberger, M., Wodniak, I, Yadykin, D., Zanca, P., Zaplotnik, R., Zestanakis, P., and Zuin, M.
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icrf ,design ,finite elements ,simulation - Abstract
In this paper we validate the finite element code RAPLICASOL, which models radiofrequency wave propagation in edge plasmas near ICRF antennas, against calculations with the TOPICA code. We compare the output of both codes for the ASDEX Upgrade 2-strap antenna, and for a 4-strap WEST-like antenna. Although RAPLICASOL requires considerably fewer computational resources than TOPICA, we find that the predicted quantities of experimental interest (including reflection coefficients, coupling resistances, S- and Z-matrix entries, optimal matching settings, and even radiofrequency electric fields) are in good agreement provided we are careful to use the same geometry in both codes.
22. Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis
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Dietrich Rothenbacher, Raphael Simon Peter, Luc Dupuis, Albert C. Ludolph, Gabriele Nagel, Torben Brehme, Angela Rosenbohm, Wolfgang Koenig, University of Ulm (UUlm), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Mécanismes Centraux et Périphériques de la Neurodégénérescence, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), ALS Registry Study Group: B Alber, F Andres, G Arnold, I Asshauer, H Baezner, H Baier, J Beattie, T Becker, F Behne, D Bengel, A Boertlein, V Bracknies, R Broer, B Connemann, S Dempewolf, C Dettmers, M Dieterich, E Etzersdorfer, W Freund, T Gersner, H Gold, W Hacke, G Hamann, M Hecht, B Heimbach, B Hemmer, C Hendrich, B Herting, R Huber, K Huber-Hartmann, P Hülser, E Jüttler, J Kammerer-Ciernioch, A Kaspar, R Kern, H Kimmig, S Klebe, C Kloetzsch, T Klopstock, A Kohler, A Kuethmann, D Lewis, C Lichy, A Lindner, D Lulé, M Mäurer, W Maier-Janson, J Metrikat, O Meudt, A Meyer, J Müller vom Hagen, A Naegele, M Naumann, K Neher, O Neuhaus, C Neusch, C Opherk, J Raape, P Ratzka, C Rettenmayr, M Riepe, J Rothmeier, M Sabolek, M Schabet, C Schell, T Schlipf, M Schmauss, L Schoels, K Schuetz, B Schweigert, N Sommer, W Sperber, C Steber, R Steber, M Stroick, M Synofzik, T Trottenberg, H Tumani, C Wahl, F Weber, M Weiler, C Weiller, C Wessig, A Winkler., Dieterle, Stéphane, Klebe, Stephan (Beitragende*r), and Technische Universität München [München] (TUM)
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Male ,0301 basic medicine ,[SDV]Life Sciences [q-bio] ,Medizin ,MESH: Community Health Planning ,MESH: Logistic Models ,Cohort Studies ,Fats ,0302 clinical medicine ,Risk Factors ,MESH: Risk Factors ,Germany ,Amyotrophic lateral sclerosis ,Vitamin A ,MESH: Cohort Studies ,MESH: Amyotrophic Lateral Sclerosis ,MESH: Vitamin A ,Original Investigation ,2. Zero hunger ,MESH: Aged ,education.field_of_study ,MESH: Middle Aged ,Middle Aged ,Prognosis ,MESH: Case-Control Studies ,3. Good health ,[SDV] Life Sciences [q-bio] ,Quartile ,Female ,MESH: Retinol-Binding Proteins, Plasma ,Cohort study ,medicine.medical_specialty ,Population ,Community Health Planning ,MESH: Prognosis ,03 medical and health sciences ,Insulin resistance ,MESH: Fats ,Internal medicine ,medicine ,Humans ,education ,MESH: Germany ,Survival analysis ,Aged ,MESH: Humans ,business.industry ,Amyotrophic Lateral Sclerosis ,Case-control study ,Odds ratio ,medicine.disease ,MESH: Male ,Logistic Models ,030104 developmental biology ,Case-Control Studies ,Neurology (clinical) ,business ,Retinol-Binding Proteins, Plasma ,MESH: Female ,030217 neurology & neurosurgery - Abstract
International audience; Importance: Knowledge about the metabolic states of patients with amyotrophic lateral sclerosis (ALS) may provide a therapeutic approach.Objective: To investigate the association between the onset and prognosis of ALS and serum retinol-binding protein 4 (RBP4) concentration as a biomarker for insulin resistance and vitamin A metabolism.Design, setting, and participants: Case-control design for risk factors of ALS; cohort design for prognostic factors within ALS cases. Between October 1, 2010, and June 30, 2014, a population-based case-control study with randomly selected controls was established based on the ALS Registry Swabia in southern Germany, with a target population of 8.4 million inhabitants. Response rates were 64.8% among the cases and 18.7% among the controls. The dates of analysis were April 2016 to May 2017.Main outcomes and measures: Serum samples were measured for RBP4. Information on covariates was assessed by an interview-based standardized questionnaire. Main outcomes and measures were adjusted odds ratios for risk of ALS associated with serum RBP4 concentration, as well as time to death associated with RBP4 concentration at baseline in ALS cases only. Conditional logistic regression was applied to calculate multivariable odds ratios for risk of ALS. Survival models were used in cases only to appraise their prognostic value.Results: Data from 289 patients with ALS (mean [SD] age, 65.7 [10.5] years; 172 [59.5%] male) and 504 controls (mean [SD] age, 66.3 [9.8] years; 299 [59.3%] male) were included in the case-control study. Compared with controls, ALS cases were characterized by lower body mass index, less educational attainment, smoking, light occupational work intensity, and self-reported diabetes. The median serum RBP4 concentration was lower in ALS cases than in controls (54.0 vs 59.5 mg/L). In the multivariable model, increasing RBP4 concentration was associated with reduced odds for ALS (top vs bottom quartile odds ratio, 0.36; 95% CI, 0.22-0.59; P for trend
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- 2018
23. Mammals show faster recovery from capture and tagging in human-disturbed landscapes.
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Stiegler J, Gallagher CA, Hering R, Müller T, Tucker M, Apollonio M, Arnold J, Barker NA, Barthel L, Bassano B, Beest FMV, Belant JL, Berger A, Beyer DE Jr, Bidner LR, Blake S, Börner K, Brivio F, Brogi R, Buuveibaatar B, Cagnacci F, Dekker J, Dentinger J, Duľa M, Duquette JF, Eccard JA, Evans MN, Ferguson AW, Fichtel C, Ford AT, Fowler NL, Gehr B, Getz WM, Goheen JR, Goossens B, Grignolio S, Haugaard L, Hauptfleisch M, Heim M, Heurich M, Hewison MAJ, Isbell LA, Janssen R, Jarnemo A, Jeltsch F, Miloš J, Kaczensky P, Kamiński T, Kappeler P, Kasper K, Kautz TM, Kimmig S, Kjellander P, Kowalczyk R, Kramer-Schadt S, Kröschel M, Krop-Benesch A, Linderoth P, Lobas C, Lokeny P, Lührs ML, Matsushima SS, McDonough MM, Melzheimer J, Morellet N, Ngatia DK, Obermair L, Olson KA, Patanant KC, Payne JC, Petroelje TR, Pina M, Piqué J, Premier J, Pufelski J, Pyritz L, Ramanzin M, Roeleke M, Rolandsen CM, Saïd S, Sandfort R, Schmidt K, Schmidt NM, Scholz C, Schubert N, Selva N, Sergiel A, Serieys LEK, Silovský V, Slotow R, Sönnichsen L, Solberg EJ, Stelvig M, Street GM, Sunde P, Svoboda NJ, Thaker M, Tomowski M, Ullmann W, Vanak AT, Wachter B, Webb SL, Wilmers CC, Zieba F, Zwijacz-Kozica T, and Blaum N
- Subjects
- Animals, Humans, Male, Female, Locomotion physiology, Herbivory physiology, Animals, Wild physiology, Behavior, Animal physiology, Species Specificity, Mammals physiology, Ecosystem
- Abstract
Wildlife tagging provides critical insights into animal movement ecology, physiology, and behavior amid global ecosystem changes. However, the stress induced by capture, handling, and tagging can impact post-release locomotion and activity and, consequently, the interpretation of study results. Here, we analyze post-tagging effects on 1585 individuals of 42 terrestrial mammal species using collar-collected GPS and accelerometer data. Species-specific displacements and overall dynamic body acceleration, as a proxy for activity, were assessed over 20 days post-release to quantify disturbance intensity, recovery duration, and speed. Differences were evaluated, considering species-specific traits and the human footprint of the study region. Over 70% of the analyzed species exhibited significant behavioral changes following collaring events. Herbivores traveled farther with variable activity reactions, while omnivores and carnivores were initially less active and mobile. Recovery duration proved brief, with alterations diminishing within 4-7 tracking days for most species. Herbivores, particularly males, showed quicker displacement recovery (4 days) but slower activity recovery (7 days). Individuals in high human footprint areas displayed faster recovery, indicating adaptation to human disturbance. Our findings emphasize the necessity of extending tracking periods beyond 1 week and particular caution in remote study areas or herbivore-focused research, specifically in smaller mammals., (© 2024. The Author(s).)
- Published
- 2024
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24. Spatiotemporal interactions of a novel mesocarnivore community in an urban environment before and during SARS-CoV-2 lockdown.
- Author
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Louvrier JLP, Planillo A, Stillfried M, Hagen R, Börner K, Kimmig S, Ortmann S, Schumann A, Brandt M, and Kramer-Schadt S
- Subjects
- Animals, Behavior, Animal, COVID-19, Cities, Communicable Disease Control, Ecosystem, Humans, Spatio-Temporal Analysis, Cats, Foxes, Mustelidae, Raccoons
- Abstract
Studying species interactions and niche segregation under human pressure provides important insights into species adaptation, community functioning and ecosystem stability. Due to their high plasticity in behaviour and diet, urban mesocarnivores are ideal species for studying community assembly in novel communities. We analysed the spatial and temporal species interactions of an urban mesocarnivore community composed of the red fox Vulpes vulpes and the marten Martes sp. as native species, the raccoon Procyon lotor as invasive species, and the cat Felis catus as a domestic species in combination with human disturbance modulated by the SARS-CoV-2 lockdown effect that happened while the study was conducted. We analysed camera trap data and applied a joint species distribution model to understand not only the environmental variables influencing the detection of mesocarnivores and their use intensity of environmental features but also the species' co-occurrences while accounting for environmental variables. We then assessed whether they displayed temporal niche partitioning based on activity analyses, and finally analysed at a smaller temporal scale the time of delay after the detection of another focal species. We found that species were more often detected and displayed a higher use intensity in gardens during the SARS-CoV-2 lockdown period, while showing a shorter temporal delay during the same period, meaning a high human-induced spatiotemporal overlap. All three wild species spatially co-occurred within the urban area, with a positive response of raccoons to cats in detection and use intensity, whereas foxes showed a negative trend towards cats. When assessing the temporal partitioning, we found that all wild species showed overlapping nocturnal activities. All species displayed temporal segregation based on temporal delay. According to the temporal delay analyses, cats were the species avoided the most by all wild species. To conclude, we found that although the wild species were positively associated in space, the avoidance occurred at a smaller temporal scale, and human pressure in addition led to high spatiotemporal overlap. Our study sheds light to the complex patterns underlying the interactions in a mesocarnivore community both spatially and temporally, and the exacerbated effect of human pressure on community dynamics., (© 2021 The Authors. Journal of Animal Ecology published by John Wiley & Sons Ltd on behalf of British Ecological Society.)
- Published
- 2022
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25. Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development.
- Author
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Gurumurthy RK, Chumduri C, Karlas A, Kimmig S, Gonzalez E, Machuy N, Rudel T, and Meyer TF
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- Chlamydia Infections genetics, Chlamydia trachomatis cytology, Chlamydia trachomatis genetics, Dynamin I genetics, Dynamin II, Dynamins genetics, Golgi Apparatus metabolism, Golgi Apparatus microbiology, Humans, Chlamydia Infections enzymology, Chlamydia Infections microbiology, Chlamydia trachomatis growth & development, Chlamydia trachomatis metabolism, Dynamin I metabolism, Dynamins metabolism, Lipid Metabolism
- Abstract
Chlamydia trachomatis is an obligate intracellular pathogen responsible for a high burden of human disease. Here, a loss-of-function screen using a set of lentivirally transduced shRNAs identified 14 human host cell factors that modulate C. trachomatis infectivity. Notably, knockdown of dynamin, a host GTPase, decreased C. trachomatis infectivity. Dynamin functions in multiple cytoplasmic locations, including vesicle formation at the plasma membrane and the trans-Golgi network. However, its role in C. trachomatis infection remains unclear. Here we report that dynamin is essential for homotypic fusion of C. trachomatis inclusions but not for C. trachomatis internalization into the host cell. Further, dynamin activity is necessary for lipid transport into C. trachomatis inclusions and for normal re-differentiation from reticulate to elementary bodies. Fragmentation of the Golgi apparatus is proposed to be an important strategy used by C. trachomatis for efficient lipid acquisition and replication within the host. Here we show that a subset of C. trachomatis-infected cells displayed Golgi fragmentation, which was concurrent with increased mitotic accumulation. Golgi fragmentation was dispensable for dynamin-mediated lipid acquisition into C. trachomatis inclusions, irrespective of the cell cycle phase. Thus, our study reveals a critical role of dynamin in host-derived lipid acquisition for C. trachomatis development., (© 2014 John Wiley & Sons Ltd.)
- Published
- 2014
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26. Direct assessment of thymic reactivation after autologous stem cell transplantation.
- Author
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Thiel A, Alexander T, Schmidt CA, Przybylski GK, Kimmig S, Kohler S, Radtke H, Gromnica-Ihle E, Massenkeil G, Radbruch A, Arnold R, and Hiepe F
- Subjects
- Autoimmune Diseases immunology, Base Sequence, DNA Primers, Flow Cytometry, Humans, Immunophenotyping, Monitoring, Physiologic, Platelet Endothelial Cell Adhesion Molecule-1 immunology, Thymus Gland physiopathology, Transplantation, Autologous, Autoimmune Diseases surgery, Lymphocyte Activation, Stem Cell Transplantation, Thymus Gland immunology
- Abstract
Methods to quantify Th cell reconstitution after immunosuppressive therapies such as hematopoietic stem cell transplantation are becoming a key issue since persistent Th cell deficiencies may result in severe complications and adverse events. We employed here cytometric monitoring of CD31+ thymus-naive Th cells for the direct assessment of human thymic function in 10 patients undergoing autologous stem cell transplantation for severe autoimmune diseases. High frequencies of posttransplant recurring naive Th cells coexpressed CD31 and stable long-term reconstitution with elevated absolute counts of CD31+ thymus-naive Th cells that were enriched with T cell receptor excision circles was demonstrated. Cytometric monitoring of CD31+ thymus-naive Th cells enables to directly evaluate human thymic function ex vivo., (2008 S. Karger AG, Basel)
- Published
- 2008
- Full Text
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27. Conserved roles of Sam50 and metaxins in VDAC biogenesis.
- Author
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Kozjak-Pavlovic V, Ross K, Benlasfer N, Kimmig S, Karlas A, and Rudel T
- Subjects
- Animals, Cell Cycle Proteins, HeLa Cells, Humans, Ion Channel Gating, Mice, Mitochondrial Membrane Transport Proteins, Mitochondrial Membranes metabolism, RNA, Small Interfering metabolism, Rats, Evolution, Molecular, Membrane Proteins metabolism, Proteins metabolism, Voltage-Dependent Anion Channels biosynthesis
- Abstract
Voltage-dependent anion-selective channel (VDAC) is a beta-barrel protein in the outer mitochondrial membrane that is necessary for metabolite exchange with the cytosol and is proposed to be involved in certain forms of apoptosis. We studied the biogenesis of VDAC in human mitochondria by depleting the components of the mitochondrial import machinery by using RNA interference. Here, we show the importance of the translocase of the outer mitochondrial membrane (TOM) complex in the import of the VDAC precursor. The deletion of Sam50, the central component of the sorting and assembly machinery (SAM), led to both a strong defect in the assembly of VDAC and a reduction in the steady-state level of VDAC. Metaxin 2-depleted mitochondria had reduced levels of metaxin 1 and were deficient in import and assembly of VDAC and Tom40, but not of three matrix-targeted precursors. We also observed a reduction in the levels of metaxin 1 and metaxin 2 in Sam50-depleted mitochondria, implying a connection between these three proteins, although Sam50 and metaxins seemed to be in different complexes. We conclude that the pathway of VDAC biogenesis in human mitochondria involves the TOM complex, Sam50 and metaxins, and that it is evolutionarily conserved.
- Published
- 2007
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28. Bak and Bax are non-redundant during infection- and DNA damage-induced apoptosis.
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Kepp O, Rajalingam K, Kimmig S, and Rudel T
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- Apoptosis physiology, Blotting, Western, Caspases metabolism, Cell Fractionation, DNA Primers, Flow Cytometry, HeLa Cells, Humans, Immunoprecipitation, Microscopy, Fluorescence, Neisseria gonorrhoeae, Permeability, RNA Interference, Apoptosis genetics, DNA Damage, Intracellular Membranes metabolism, Mitochondria metabolism, bcl-2 Homologous Antagonist-Killer Protein metabolism, bcl-2-Associated X Protein metabolism
- Abstract
Mitochondrial outer membrane permeabilization (MOMP) and release of mitochondrial intermembrane proteins like cytochrome c are critical steps in the control of apoptosis. Previous work has shown that MOMP depends on the functionally redundant multidomain proapoptotic proteins, Bak and Bax. Here we demonstrate that Bak and Bax are functionally non-redundant during Neisseria gonorrhoeae (Ngo)- and cisplatin-induced apoptosis. While the activation of Bak is caspase independent Bax activation needs Bak and active caspases. Silencing of either Bak or Bax resists both Ngo- and cisplatin- but not TNFalpha-induced apoptosis. Activation of Bak is required to release cytochrome c from the mitochondria; however, Bax is still required to activate effector caspases. Thus, both Bak and Bax are necessary to accomplish DNA damage and Ngo-induced apoptosis.
- Published
- 2007
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29. Post-thymic in vivo proliferation of naive CD4+ T cells constrains the TCR repertoire in healthy human adults.
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Kohler S, Wagner U, Pierer M, Kimmig S, Oppmann B, Möwes B, Jülke K, Romagnani C, and Thiel A
- Subjects
- Adult, Autoimmunity, Cytokines pharmacology, Humans, Leukocyte Common Antigens analysis, Middle Aged, Platelet Endothelial Cell Adhesion Molecule-1 analysis, Aging immunology, CD4-Positive T-Lymphocytes immunology, Lymphocyte Activation, Receptors, Antigen, T-Cell physiology, Thymus Gland immunology
- Abstract
In spite of thymic involution early in life, the numbers of naive CD4(+) T cells only slowly decline in ageing humans implying peripheral post-thymic naive CD4(+) T cell expansion. This proliferation may compensate for continuous activation and death of naive CD4(+) T cells but may also have negative consequences for protective immunity. Here we show that naive CD4(+) T cells that have proliferated in the periphery are characterized by a highly restricted oligoclonal TCR repertoire. Additionally these cells, which constitute the majority of naive CD4(+) T cells in the elderly, display signatures of recent TCR engagement. Our results demonstrate for the first time that peripheral post-thymic proliferation of naive CD4(+) T cells in healthy human individuals causes a significant contraction of the peripheral TCR repertoire. This age-dependent deterioration of CD4(+) T cell immunity could entail ageing-associated autoimmunity, increased susceptibility to infection or cancer and decreased efficiency of vaccination.
- Published
- 2005
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30. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood.
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Kimmig S, Przybylski GK, Schmidt CA, Laurisch K, Möwes B, Radbruch A, and Thiel A
- Subjects
- Adult, Antigens, CD34 immunology, Flow Cytometry, Humans, Leukocyte Common Antigens immunology, Thymus Gland cytology, Thymus Gland immunology, Aging immunology, Receptors, Antigen, T-Cell immunology, T-Lymphocyte Subsets immunology
- Abstract
During ageing thymic function declines and is unable to meet the demand for peripheral T helper (Th) cell replenishment. Therefore, population maintenance of naive Th cells must be at least partly peripherally based. Such peripheral postthymic expansion of recent thymic emigrants (RTEs) during ageing consequently should lead to loss or dilution of T cell receptor excision circles (TRECs) from a subset of naive T cells. We have identified two subsets of naive Th cells in human adult peripheral blood characterized by a striking unequal content of TRECs, indicating different peripheral proliferative histories. TRECs are highly enriched in peripheral naive CD45RA(+) Th cells coexpressing CD31 compared with peripheral naive CD45RA(+) Th cells lacking CD31 expression, in which TRECs can hardly be detected. Furthermore we show that CD31(-)CD45RA(+) Th cells account for increasing percentages of the naive peripheral Th cell pool during ageing but retain phenotypic and functional features of naive Th cells. As CD31 is lost upon T cell receptor (TCR) engagement in vitro, we hypothesize that TCR triggering is a prerequisite for homeostatically driven peripheral postthymic expansion of human naive RTEs. We describe here the identification of peripherally expanded naive Th cells in human adult blood characterized by the loss of CD31 expression and a highly reduced TREC content.
- Published
- 2002
- Full Text
- View/download PDF
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